LOCUS       c00005_JAFIWH0..       13527 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAFIWH010000067.1 Streptococcus thermophilus strain 252
            NODE_14_length_50042_cov_87.390994, whole genome shotgun sequence.
ACCESSION   JAFIWH010000067
VERSION     JAFIWH010000067
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 00:31:31
            Original ID  :: JAFIWH010000067.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 36515
            Orig. end    :: 50042
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13527
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[46515:48675](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12160)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     cand_cluster    1..13527
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13527
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     CDS             complement(321..626)
                     /locus_tag="ctg5_42"
                     /transl_table=11
                     /translation="MSHNHDYNHDHEVITLVDEQGNETLFEILLTIDGREEFGKNYILL
                     VPAGAEEDADGEIEIQAYSFTENEDGTEGDLQPIPEDSDAEWDMIEEVFNSFIDEN"
     CDS             complement(735..1154)
                     /locus_tag="ctg5_43"
                     /transl_table=11
                     /translation="MRVMGLDVGSKTVGVAISDPLGFTAQGVEIIKINEEAKEFGFDRL
                     GELVKEYQVDKFVVGLPKNMNNTEGPRVEASKAYGAKIKEIFNLPVDYQDERLTTVQAE
                     RMLVEQADVSRGKRKKVIDKLAAQLILQNYLDRMF"
     CDS             complement(1154..1420)
                     /locus_tag="ctg5_44"
                     /transl_table=11
                     /translation="MGFTDETVRFNLNDGDKDEISNTLTNVYRSLAEKGYNPINQIVGY
                     VLSGDPAYVPRYNDARNQIRKYERDEIVEELVRYYLKGNGTDL"
     CDS             complement(1547..1735)
                     /locus_tag="ctg5_45"
                     /transl_table=11
                     /translation="MAKVCYFTGRKTVSGNNRSHAMNKTKRVVKPNLQKVTVLIDGKPK
                     KVWASARALKSGKVERV"
     CDS             1905..3173
                     /locus_tag="ctg5_46"
                     /transl_table=11
                     /translation="MPDNLALRMRPRSISEVIGQKHLVGEGKIIRRMVEANMLSSMILY
                     GPPGIGKTSIASAIAGTTKFAFRTFNATVDSKKRLQEIAEEAKFSGGLVLLLDEIHRLD
                     KAKQDFLLPLLENGNIIMIGATTENPFFSVTPAIRSRVQIFELEPLSNEDIKEAILNVL
                     GDKERGFAFEVHLDDDALDFIATATNGDLRSAYNSLDLAVMSTPASGNGQHHITLDIVE
                     NSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVNASLHYAARLVEAGDLPSLARRLTVI
                     AYEDIGLANPDAQVHTVTALEAAQKIGFPEARILIANVVIDLALSPKSNSAYKAMDAAL
                     ADLRKSGNLPIPRHLRDGHYAGSKALGNAQDYKYPHAYPEKWVKQQYLPDKLRGVNYFQ
                     PNETGKYERALGANKERIDKLSK"
     CDS             complement(3840..4412)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 145.2; E-value:
                     4.4e-44)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_47"
                     /transl_table=11
                     /translation="VEKDGETILAPCDLTIHAGEKIAIIGESGAGKTTLLNILYGEIHP
                     SQGQIRYQGRELTSCQLYQAGAYILQSSHVFDDLSVEENIALGQEIDQQRMDNILQETG
                     LLSLKGKVPSNQTLSGGEKQRLEIARALYHKRQFILADEVKANLDAKNQEKINQLLFSL
                     PQAVVEVIHHYTKEDLKCYDKVIHLKK"
     CDS             4446..4691
                     /locus_tag="ctg5_48"
                     /transl_table=11
                     /translation="LVKYAVSSQLISKQVLILIAEGLGRLAGIDKVGQFLKLVADVVGD
                     QINADKTSRRKVVLVGHESANHNGRHRAKCIYTVDK"
     CDS             4731..4943
                     /locus_tag="ctg5_49"
                     /transl_table=11
                     /translation="LQRLFYVFRKSLEKQILALIMTNRSNTCNHIVDTGDIILICQGFL
                     LRNPIQTLRTQSATQNWYRVKDDKQ"
     CDS             complement(5374..6201)
                     /locus_tag="ctg5_50"
                     /transl_table=11
                     /translation="VKIETVTNGTVLNKRVKEMLVKFHPYLTISLDGPEIVHDRLRGRG
                     SHRKTLRFINYLKNIDYENFEIASTYTRLHQKNGLSREDIFQYFTDMDVHFNINDVFTK
                     NKVLIVKEMEKSLAERKQFIDKSIQHVINNNEKAFISPILYDVLISMIYKSTNRTFCDD
                     IDPSNTLTYDVDGSKKLCFRFWGTHNSPKAESFNNKDNFEKCKNCWCRGMCLECVANVI
                     DGYSSVISEDGEFLECSKPELMEYCIKQIIYLSKDREKLSRLVNNFRGFIRYA"
     CDS             complement(6255..6572)
                     /locus_tag="ctg5_51"
                     /transl_table=11
                     /translation="MIKTIETDIGTYYFDSVNFTLSLSPISKQSSPTLDYVEDGVLKKV
                     VINISNSCNLSCSYCYADGGNYGMDNRIMDLTTADNIIQEIASKGVTQSTVSYFSGENL
                     F"
     CDS             complement(6629..6736)
                     /locus_tag="ctg5_52"
                     /transl_table=11
                     /translation="MEKLQVIDLEELLEFDQGYVINASCGPSHSCGGGR"
     CDS             complement(6814..7512)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_53"
                     /sec_met_domain="TIGR01716 (E-value: 5e-49, bitscore:
                     158.7, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIEEFVYAVRDFRRDDFNELLEKIRYLVSNRDIDGMKKLLISQM
                     EKKDKKEPFASFNTILIKIRLQDLSGETYVTDQEIVTISDYLFSAEYWGYYELLLFMNT
                     IDALNHNTMMILAKEMCHRSDFYRDIPNNRRLLATMLLNAYITCIERNEWMDALYFEKQ
                     LKYCNFSETEMYEKLVLHYANNLYDLKKNNNRHAVLEMRKCIAATKLVDSNQIAIKFEN
                     YLQKVLDDMR"
     CDS             complement(8428..9996)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 127; E-value: 1.4e-38)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_54"
                     /transl_table=11
                     /translation="MKKYILKYKLLNLIHIILIGFSSAFLVGASVTLSIMLNKLVESDF
                     KGFLIWLGIEFGVYLLFLADTYLIRVNQTKLIQKMTLSLRDDYINSLTRKSFSEFKNKT
                     VGEHLSILNNDIKIIEESGFESFYSLVSTVFTTFFSIIALFSYDYRIVLLSILLTLILT
                     YLPRSFAHKMEKAMKRFSIGNETFISSLTDQLLGYDTLYYSNKKEMLSIKCGEVIKKFI
                     FEKIVFIKTSSLIEIIMSLFSIISQMLVLLLTGYLIILKQVSIGSISSVGQISGNIFNS
                     LTTFNQLQVSISSVNSIFEKFGAFEKSSHYRYIDKDIEEIKLTNVGYSFKNKEVFKNIN
                     CSFEKGKNYAIVGESGSGKSTLINIILGNNKQYSGSVKYNDVEISDIEESQLFKSVSYI
                     GNITHIYHDSLRNNLTLWDNKINESEIINILKQVNLIDLIPRLDDEVSMSFLSEGQKQR
                     LGIARAYLTKTNVIIMDESMANLDRDNAFLIENQLLNDPTRMYITVSHHLQEKLLDRFH
                     SIITL"
     CDS             complement(10001..12160)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_55"
                     /sec_met_domain="LANC_like (E-value: 3e-08, bitscore: 24.7,
                     seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.1e-12, bitscore: 39.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEELITPSEKRIINRKKGEIYDYISYSNAFVLYQGWKIHISANLI
                     DYQSILDNVYHVCSIFQTPFKYINKISELFRILSKHVSQLEIGKFITIYPKNKETFLLL
                     LEELYDKIPKYTGVQILTDRSYKDSEIIFYRYGVMNARLINNERPKLKFNGTFYEDITE
                     PYYTCPPFVEDIIFNKVVDDYNIESLFHDRYQMESIIHKSGAGNVYIAIDTINEEKVII
                     KEARKKVYITEKILAIDLLLNEKCILKKLKGKVDIPNYIECFTIEGNLYLVEEFIDGQR
                     LDILKPEYNLLIKRNSSELGRYNKKVKKIISNLFLSLYKIHQEGIILEEISSSNILLTN
                     DDRVFFIDLETAYNKNDGIIVETTNECYPKNISQKNEQRDIVKMWYCIIDLLTNSTSLL
                     KYDNTGVSTLNLFYKMSLENNLPKSLRKKFINDFSIVDFKNTFIIKFIEMGLNIEKIVR
                     MQQDLTETILSHNTFEIHGKTILESIDNYKHISNMDLKFSSDPSFSSLYDNCNKSIDDL
                     IGIAILDNNFELFLNYNLDELLHDMSYYQKYYLLRLFNDTKICDRVYFIKVLNSIIKND
                     IKCIDGVKYIKSNEYFSPYLITGNSGLIIELIKFSKNNNTMKFDEWIRSLSEGISYTYA
                     KGTSLYYGLAGLGLANAWLYYYFKETSFLKTSIKICEHIFDFSIKQNTKTILIDPMSEE
                     IDYTYSKGMLGQLYFINELLNIIKE"
     CDS             complement(12245..13117)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_56"
                     /sec_met_domain="TIGR01716 (E-value: 1.2e-31, bitscore:
                     101.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDTIDIGSLTKKIRLSKKLSLKDVAGDYLSVSFLSKFERGESEI
                     SLSRFLCILENLDVSIEEIYGILSKDNPTRTEELLARVSKAFQQNNIPALKKYYYEEIE
                     KFNSTHKKIFLYNSILIDSFLISITGKKMNKKHIEVISDYLFDIDQWGKRELVILGNSM
                     SAVPTNTLNLLIKEIIYKTTLFGNNEENKKIKIDLILNGISIFLERKELNYAKFYINLF
                     DTLTIPEVYLYERVEYNILIGTYWILIGKIEVGKKKIELALESLKNLGAENLLLMRENE
                     YEELLNSII"
     CDS             complement(13131..13268)
                     /locus_tag="ctg5_57"
                     /transl_table=11
                     /translation="MIIQILNSLPSDSFEFKDRLRITYTPNIQKVNADCIMFAFFVIIV
                     "
     CDS             complement(13277..13366)
                     /locus_tag="ctg5_58"
                     /transl_table=11
                     /translation="MTTQNLNKLPGTIAVPMDKIRITIYCPSF"
ORIGIN
        1 cttcaccctt ttcagattgc ttatcatgtg tatgagattg atgggggctt cgataataac
       61 cttgatagct acctgatcct aggatattgt ctttgttata tggactcaaa ttaaactcct
      121 ttgctgtcat tttgaaagtt acaaataagg gaaaaaacca aaatctctta tttaaagtat
      181 atcagataat accatttagt caatttctct cttatttctt acatttaagc atttacttct
      241 aaaaaagaga ctgaaataaa ctatttcagt ctctttttta gaagtaaatg cttaggctta
      301 gttacgccca atattatttt ttagttttca tcgataaagc tattgaaaac ttcttcaatc
      361 atatcccatt cagcatctga atcttcagga attggttgaa ggtcgccttc agtgccgtcc
      421 tcattttcag tgaatgagta tgcctggatt tcgatttctc catctgcatc ttcttcagca
      481 ccagctggaa ccaaaagaat gtagttctta ccgaattctt cacgtccatc aatcgttaat
      541 aagatttcaa aaagtgtttc attcccttgt tcgtctacta aagtgatgac ttcatggtca
      601 tggttgtaat cgtgattgtg tgacatattg ttctcctttt tggtgagagt attcaatagt
      661 gaggtgaatc tagaagttct gactgggagt tcactagatt gtcgctcgac taatcggtct
      721 ctatttacag tttattaaaa cattcgatcg aggtagtttt gcagaataag ttgagcagcc
      781 aatttatcaa taactttttt acgcttacca cggctgacat ctgcttgttc aactaacata
      841 cgttctgcct gaacagttgt caatcgctcg tcttggtaat ctacaggaag gttaaagatt
      901 tccttaattt tagcaccata agctttgcta gcctcaacac gtggtccttc agtgttattc
      961 atatttttag ggagaccaac gacaaattta tctacctgat attctttaac gagttcacct
     1021 agacggtcga agccaaactc tttagcttcc tcgttaattt tgataatttc aacgccttgg
     1081 gccgtaaaac caagtgggtc actaatagca acacccactg tttttgagcc aacatcaagt
     1141 cccattactc gcattagagg tcagttccat ttcctttaag ataatagcga acgagttctt
     1201 caacgatttc atcacgttcg tatttgcgaa tttggttacg ggcatcattg taacgcggaa
     1261 cataagcagg gtcaccgctc agaacataac caacgatttg gttgatagga ttataacctt
     1321 tctcagccaa cgaacggtag acatttgtca aagtattact gatttcatct ttatcaccgt
     1381 cgtttaggtt gaaacgaaca gtttcatctg taaatcccat actgacacct tctttctata
     1441 aggattatct attagtttct tattataaca taagtatacc caaaagtgaa agacgatgaa
     1501 tattaaaaga gatgactgat gtcatctctt ttaatatcta ataagattaa acgcgttcaa
     1561 ctttaccaga tttaagtgca cgagctgaag cccaaacttt tttaggttta ccgtcgataa
     1621 gaacagtaac tttttgaagg ttaggcttaa cgacacgttt agttttgttc atagcgtgtg
     1681 aacggttgtt tccagaaaca gttttacgtc ctgtaaagta acatacttta gccatttcgt
     1741 gttttcctcc taggtagaat ttattacgga tgtgctagca ccacatacca aaatattcta
     1801 tcataagaat ttaggtttga caagaactat ttataatttc tttttacaga aaaatagtat
     1861 attcttatta taagaggaat aaatagttaa aaaaaggaga gaagatgcca gataatcttg
     1921 ccttacgcat gcgtccacgt tcaatttcag aggtgattgg tcagaaacat ttagttggtg
     1981 aaggtaaaat tattcgccgt atggtagagg cgaatatgct gtcgtcaatg attctctacg
     2041 gacctccagg aattgggaaa acctcgatag ctagtgctat tgcaggaaca acaaaatttg
     2101 cttttagaac ttttaatgcc actgtcgata gcaaaaaacg tctgcaggaa attgcagaag
     2161 aggctaaatt ttcaggtggt ttagttctgc ttctagatga gattcatcgt ttggataaag
     2221 cgaaacaaga ttttttgtta ccattattag agaacggaaa tattatcatg attggtgcca
     2281 caaccgagaa tccgtttttt tctgtaacac cagccatccg tagccgtgta caaatatttg
     2341 agttggaacc actctctaat gaagatatca aggaagctat tttgaatgtt ctaggggaca
     2401 aggagcgtgg cttcgccttt gaggttcact tagatgatga tgctctagat tttattgcga
     2461 cagctactaa tggtgattta cgatcggcat ataattcttt ggatctggct gtcatgtcga
     2521 caccagcttc aggaaatggt cagcatcata ttaccttaga catagtggaa aatagcttac
     2581 aacgcagtta tattactatg gataaagacg gtgatgggca ctatgatgtc ctttctgcct
     2641 tgcaaaaatc tattcgagga tctgatgtta atgccagtct tcactatgcg gcacgtttgg
     2701 ttgaggcagg agatttgcct agtctagcac gtcgcttgac tgtgattgcc tatgaggata
     2761 ttggtttagc taatccagat gcacaagttc acacggtcac agccttggaa gctgcacaga
     2821 aaataggttt tccggaggca cgtattttga ttgccaacgt agttattgac ttagcattat
     2881 cacctaagtc gaattcggct tataaggcaa tggatgctgc cctggcggat cttagaaagt
     2941 ctgggaattt acctattccg cgtcatctga gagatgggca ctatgctgga agtaaggcac
     3001 tgggtaatgc acaagattat aagtatccac atgcctatcc tgaaaagtgg gttaagcaac
     3061 aataccttcc agataaatta agaggagtca attatttcca acctaatgaa actgggaaat
     3121 acgaaagagc tcttggagct aataaagaac gaattgataa gttatcaaag taacaagtga
     3181 gatagggact aacgaaaacg attgcaaaaa aaattgattt ttcctcttgc aataattttc
     3241 aaaagtggta ttataaaaac atagaaattg ctgtggtata cgaatccaca tataagtgtt
     3301 gaccgactaa tttttgtatt atcgggagac agaggtctat taacagtgtg caggctggct
     3361 cacccagaag caactgaagt tagtagcgag tcgcccacct gcttttttac gtcgcgggtt
     3421 caatacaaac tgtggatcat cggtaccaat acagcatcca gcctccttag ctcagttggt
     3481 agagcagtgg actcttaatc catgggtcac aggttcgagc cctgtagggg gcatctaaat
     3541 caacaggaaa aagccttaat ttacaaggct tttttgcttg tctataactg atttgcccta
     3601 tcatttgccc cacatttttt tatgagcaat ctttccagac atctctgatt tgattaaatt
     3661 cctcaaaaat tttctcctct aaagtgtgtc catatacttc tactaacatt gaaatatctc
     3721 tatgccctag aatttttgca ataactccaa ggtcagaacc tttgtgccag aggtatcttc
     3781 cataggtatg acgtgctcct ttcagatata caatttgtct atagacacta ttggcataac
     3841 tactttttca aatgaatcac tttatcatag cacttcaagt cttccttggt gtagtggtga
     3901 atgacctcca ccacagcttg aggaagtgaa aagagcagct ggttgatttt ttcttgattt
     3961 ttggcgtcca ggttagcctt gacctcatct gctaggataa actgtcgctt gtgatagaga
     4021 gcacgggcaa tttcaaggcg ctgtttttca ccgcctgata aagtttggtt gctgggtacc
     4081 ttgcctttta ggctgaggag ccctgtttct tgcaagatgt tatccattct ttgctggtca
     4141 atttcctgtc ccagagcgat gttttcctcc acagataaat cgtcaaaaac atgactagat
     4201 tgcaagatat aggcaccagc ctgatagagt tgacagctgg ttagttcccg tccttgataa
     4261 cgaatttgcc cctgactagg atggatttcc ccgtatagga tgttgagcag ggtggttttg
     4321 cccgctccgc tttctccgat gatagcaatc ttttccccag cgtggatagt cagatcacaa
     4381 ggagctagaa tggtctcccc atccttctcc acactgacct gctccaactg gataggaaag
     4441 acagattggt caaatatgct gtcagtagcc aacttatttc caaacaagtc ttgatactta
     4501 tcgcagaggg acttggcaga cttgcgggta ttgataaagt aggacagttc ttgaaactgg
     4561 tagccgatgt tgtgggagac cagataaatg ccgacaaaac tagccgcaga aaggtagttc
     4621 tggtaggtca tgaatccgcc aatcacaatg ggcgccacag agcaaaatgc atctatactg
     4681 ttgataaata aactgttcag tgaccgttgc ttttcgtagg acacttcttc ttgcaacgcc
     4741 tgttctatgt ctttagaaaa tctcttgaaa aacaaattct ggccctgata atgacgaata
     4801 ggagcaacac ctgcaatcat attgttgaca cgggcgatat aattctgatt tgccagggat
     4861 ttttgctccg caatcctatc caaacgcttc gaacccagtc cgctacacaa aactggtacc
     4921 gagtaaaaga tgataaacaa taaccccaga tagaaattgg tccagagggc atatgcgatg
     4981 gaaacgactg taaaacctag cgaggatacg ataatgacgg tcggctctat atagctattt
     5041 tccaactgtt ggacatcatt ttccagatca gacagcacct cctcatcagg aatctgacgg
     5101 ctgtataaaa aagtccgaaa aatagcgcgt tttatcccaa ccttaaagtc agtcatcaaa
     5161 cgagcatagt aatagcgctt cccagccaag cccaggacaa gcaccagatt gcccccaatc
     5221 ccccagagca aaatctgcca gaggagatgc aactggcggt tggtaaaact agcgacgata
     5281 tactggataa gggcaggggt gataatggcc tctaaccaag tgatgacgat ggctagaaaa
     5341 tagaaggtga gatgtttttt cgttacataa ctcctaagca tagcgtataa accccctaaa
     5401 attatttacc aacctagata atttttctct gtccttggat aaatatataa tctgtttaat
     5461 acagtattcc atcagttctg gtttagagca ttcaagaaat tccccatctt cactaattac
     5521 agaagaatat ccatcaataa cattggcaac gcattccaag cacatacctc tacaccagca
     5581 gtttttacac ttttcaaagt tatctttgtt gttaaatgat tccgctttag gactgttgtg
     5641 agttccccaa aatctgaaac atagtttctt actaccatct acatcataag ttaatgtatt
     5701 cgaagggtca atatcatcac aaaatgtacg attcgtactc ttgtatatca ttgatattaa
     5761 tacatcatat aaaataggac tgataaatgc cttctcattg ttgttgatta catgttgaat
     5821 ggatttatct atgaactgtt ttctttcagc caaacttttt tccatttctt tcacaattag
     5881 cactttattt ttagtaaaaa catcatttat attaaaatgc acatccatat cagtaaaata
     5941 ttgaaagata tcttctctac ttagaccatt tttttgatga agtctagtat atgtcgaggc
     6001 tatttcaaaa ttttcataat caatattctt taaataatta ataaaacgta atgtttttcg
     6061 atggctccct cttcctctga gtctatcatg aacaatttct ggtccatcta aacttatggt
     6121 taaataagga tgaaatttaa caagcatttc tttaacacgc ttatttaaaa cagtaccatt
     6181 agtaactgtt tcaattttca ctacatttaa taatgtagat aatttttcta taaaatatat
     6241 aaataattct atatttaaaa aaggttctcc cccgaaaagt atgagacggt tgattgtgta
     6301 actcctttac ttgctatctc ttggataata ttatcagcag tagttaaatc cataatacga
     6361 ttatccatac catagttacc accatctgca taacaatacg aacaagataa attacaacta
     6421 ttagaaatat ttataactac tttttttaat acaccatctt caacataatc tagagttggt
     6481 gaactttgtt ttgaaatagg tgacaaagat aaagtaaaat taacagaatc aaaataatat
     6541 gttcctatat ctgtttctat tgtctttatc ataattatcc tccagactaa aaactgagat
     6601 gaggaatcac tcctcatctc ggaagaagct atcgaccacc gccacaagaa tgacttggac
     6661 cacagctagc attaattaca tacccttgat caaactctaa aagttcttca aggtcaatca
     6721 cctgaagttt ttccatggtt tttacctcct ttatttgata gtttcattat ataaccttat
     6781 cagaagagga taatattttc ccttatacgc aattcacctc atgtcatcta atactttttg
     6841 taaataattt tcaaatttta tagctatttg attgctatct accaatttcg tggcagcaat
     6901 acattttctc atttccaaaa cagcatgtcg attattattt ttctttagat catataaatt
     6961 attagcataa tggagcacta gtttttcata catttcagtc tctgaaaagt tacaatattt
     7021 tagctgtttt tcaaaataaa gagcgtccat ccattcattg cgttcaatac aggtgatata
     7081 agcattgagc aacatagttg ccaataaacg tctattattt ggaatatctc tataaaaatc
     7141 cgaacgatga cacatttctt tggctaaaat catcattgtg ttatgattta aagcgtctat
     7201 tgtattcata aacagtagca attcataata accccagtat tccgcagaaa acaagtaatc
     7261 actgatagta acaatctctt ggtctgttac ataagtttct cctgataaat cctgtaatct
     7321 tattttaatc aaaattgtgt taaatgaagc gaaaggttcc tttttatcct tcttttccat
     7381 ttggctaatt aatagctttt tcattccgtc tatatcacga tttgatacta aataccgaat
     7441 cttttctaaa agttcattaa agtcatctct gcggaaatca cgtacagcgt aaacaaattc
     7501 ttcgataggc atatgtattg catctaacga taaaaaaatt tgctgatggt taaatcagcc
     7561 tcatcatttt caaatcttga gagatgggaa tttgaaagac ctgattttgc aacatttttt
     7621 aaagataaac ctcgagattc tctaaatttt ttaaaaattt ttccatattt cattctagtc
     7681 acctcctaaa ttgcttataa gggaaatttc ttcacaaata ttaaaaatat tatatcatat
     7741 aagaaaacga aaagaggtat ttaccatgaa taaaaaagca ttgtttagtt tgttgtttgt
     7801 aatacttgaa ggtattatcg ttatcggagt aggttagcca aatgataaag agattaggta
     7861 agaaacctta aaataaaaaa tagcttagaa ttacgtcatt ataaacgttg attccaagct
     7921 atttttggtt attaaaattt taatcagaag ggtaaaatta tagtttttgc ccaacctctc
     7981 ttgattttat ggaaaaataa tcccgtattt tggatacgaa atgctttcaa taagtgtaaa
     8041 tcagttttaa cgtttactaa atttcgatgc tttacgagcc tttttcaagc ctggttttca
     8101 aagcaagttg gaaaccttta tgagtcattc gtttttgccc cacttttgcc ccattttgaa
     8161 ataattatat ttaaaaatgc tccaagtatc ttctaaaatt aacttatatt taaacatttt
     8221 gattattttc aatatgaaaa attcatacaa attcatgtag gggggcatca tactatacat
     8281 aaaaaaagcc tttaaataaa ggctttttta cttgtctaaa gaggaaatgt cccatcattt
     8341 gtccccgaaa taatttccaa acttttgata aatattattt ttgtataaat taatttttgt
     8401 tgtgtatagt aacattgaat tctcaattta aagtgtaata atactatgaa atctatctag
     8461 tagtttttcc tgtaagtgat gagagacagt aatgtacatc cttgtaggat cgtttaatag
     8521 ctggttctca attagaaaag cgttatctct atctaaattt gccatagatt catccattat
     8581 tattacgtta gttttagtaa gataggcacg tgcaatacct aatctttgct tttgcccttc
     8641 tgataaaaaa gacatactta cttcatcatc taatcgtgga attaaatcta ttaaattaac
     8701 ttgtttaagg atattgataa tttctgattc atttatttta ttatcccaaa gtgttaaatt
     8761 atttctaaga gaatcatgat aaatatgagt aatatttcct atatatgaaa cgcttttaaa
     8821 caattgagat tcttcaatat cagatatctc tacatcattg tattttacac ttccactata
     8881 ttgcttatta tttcctaaaa ttatatttat taaagttgat tttccactac ctgactctcc
     8941 aactatggca taattttttc ctttttcaaa actacaattt atatttttga aaacttcctt
     9001 atttttgaag gaatacccga cattagttaa cttgatttct tcaatatctt tatcaatata
     9061 tctataatgg gaactcttct caaaagctcc aaatttttca aatatactat ttactgacga
     9121 tattgatacc tgtaattgat taaacgtagt taatgagtta aatatatttc cggaaatttg
     9181 tccgactgat gatattgaac caattgaaac ttgttttaaa atgataagat aacctgttaa
     9241 aagtagtact aacatttgag aaataattga aaataaactc attattattt caattaagct
     9301 actagtttta ataaatacta ttttttcaaa aataaatttt tttattacct ctccacattt
     9361 aattgataac atctcttttt tatttgaata atatagcgta tcatatccca gtaattgatc
     9421 tgttagtgat gaaataaatg tttcattacc tatagaaaat cttttcatag ctttttccat
     9481 cttatgggca aaacttcgtg gaaggtaagt taggatcaaa gtaagtagta tagataaaag
     9541 cactattcta taatcataac taaacagagc aataattgaa aaaaaagttg tgaaaactgt
     9601 tgaaactaat gaataaaagc tttcaaatcc gctttcttcg ataattttta tatcgttatt
     9661 taaaattgac aagtgttctc caacagtctt atttttaaat tcactaaacg attttctagt
     9721 tagactgtta atataatcat ctctgagaga aagagtcatt ttttgaatta atttagtctg
     9781 atttactcta attaagtatg tatctgccaa aaataacaaa taaactccaa attcaatgcc
     9841 taaccatatg aggaagcctt taaaatcact ttcaaccaat ttatttaaca tgattgagag
     9901 tgtgactgat gctccaacta aaaatgcaga actaaatcct attaatatta tatgtataag
     9961 atttagcagt ttatatttta gtatatattt tttcattatg ttattcctta attatattta
    10021 gcaactcatt aataaagtac aactgcccca acattccttt tgaatatgta taatcaattt
    10081 cttcggacat cgggtctatc aatatagttt ttgtattttg tttaatagaa aaatcaaaaa
    10141 tatgttcgca aatcttaata ctcgttttaa gaaatgaagt ttctttaaaa taataataaa
    10201 gccaagcatt tgccaaaccc aatcctgcta atccataata caatgaggtt cccttagcat
    10261 atgtataact aattccttct gataaacttc taatccattc atcgaacttc attgtattgt
    10321 tatttttact gaacttaata agttcaatga ttaacccaga gttaccagtt attaaatatg
    10381 ggctaaaata ctcgttggat tttatatatt tcactccatc aatacactta atatcatttt
    10441 tgatgattga atttaggacc tttataaagt agactctatc acatatttta gtgtcattga
    10501 aaagtctgag tagataatat ttttgatagt agctcatatc atgtagtagt tcatctaaat
    10561 tataatttaa aaaaagttca aaattattat caagtatagc gattccgatt aagtcatcta
    10621 tacttttatt acaattatca taaagagaag agaaactggg atcgctagaa aattttaaat
    10681 ccatattact aatatgttta taattatcaa ttgactctaa tattgttttt ccatgaattt
    10741 caaaagtatt atgggaaagt atagtttctg ttaaatcttg ttgcattcta actatttttt
    10801 ctatatttaa acccatttca ataaatttta ttataaatgt attcttaaag tccactatac
    10861 taaaatcatt aataaatttt tttcttaaag atttaggtaa attattctct aaactcattt
    10921 tataaaataa atttaaggta ctcactcctg tattatcata ttttaaaaga ctagtagaat
    10981 tagttaataa atcaattata caataccaca ttttaacaat atctcgctgt tcattttttt
    11041 gagaaatgtt tttgggatag cattcatttg tcgtctcaac aataattcca tcattcttat
    11101 tatatgcggt ttcgagatca ataaaaaata ctctatcatc atttgttaaa agaatattac
    11161 ttgaagatat ttcctctaat attattccct cctgatggat tttatataaa cttaaaaata
    11221 gattagaaat tatttttttt acttttttat tatatcttcc taactcgcta gaatttcgtt
    11281 ttatcaacaa attatattca ggctttaaaa tatccaatct ttgtccatca atgaattcct
    11341 caacaagata taaatttccc tcaattgtaa agcactcaat gtaatttgga atatcgactt
    11401 tacctttcaa tttttttaga atacatttct catttaaaag gagatctatt gctaaaatct
    11461 tttctgtaat atatactttt tttctagctt cttttataat aaccttttct tcattaatag
    11521 tatcaatcgc aatatataca ttacctgctc ctgatttatg aataatagat tccatttgat
    11581 atctatcatg gaataaagat tcaatattat agtcatctac aactttatta aatatgatat
    11641 cttcaacaaa tgggggacat gtatagtatg gttccgttat atcttcataa aaggttccat
    11701 taaatttaag ttttggtcgc tcattattaa ttaaacgtgc attcattact ccatatctat
    11761 aaaaaattat ttctgagtct ttataacttc tatctgtcaa aatttgaact ccagtatatt
    11821 tgggtatctt atcatatagt tcttccaata ataataaaaa agtttctttg tttttaggat
    11881 atatagttat aaattttcca atctctaatt gcgaaacgtg ttttgataaa atacggaata
    11941 actcagatat tttattgata tacttaaatg gcgtttgaaa aatagaacaa acatggtaaa
    12001 cattatctaa aatagactga taatctatta aattagcaga tatatgaatt ttccaacctt
    12061 gataaagaac aaaagcattt gaatatgaaa tataatcata tatttcccct ttttttctat
    12121 taatgattct cttttcactt ggtgtaatta gttcttccat gataaatctc ctattaaaaa
    12181 taaaatactg ctgtataact atataactag tgtaacagca gtattttatt tttagtaaaa
    12241 agtgtcatat aatagaattc aataattctt catattcatt ttctctcatt agcagtaaat
    12301 tctcagcacc taaatttttg agggattcca aagctagttc aattttcttc ttgccgactt
    12361 ctattttacc tataagtatc caatatgtac ctattaatat attatattcc actcgctcat
    12421 agagataaac ttcaggaatg gtaagtgtat caaaaagatt aatatagaac ttggcataat
    12481 ttagttcttt cctctctaaa aatattgaga ttccgtttaa aataagatca atttttattt
    12541 ttttattttc ctcattatta ccaaataaag tagtcttata aataatttct tttattaata
    12601 aatttaatgt atttgtaggc accgctgaca tactattacc taatattact aactctcttt
    12661 tcccccattg atctatatcg aaaagataat cagaaataac ttcaatatgt tttttattca
    12721 tttttttacc tgttatcgat attaaaaatg aatcaatcaa aatagaatta tataaaaata
    12781 tttttttgtg tgttgaatta aacttttcta tttcttcata ataatatttt tttagagcag
    12841 gtatgttatt ttgttgaaat gccttactga cccttgctag taattcctca gttcttgtag
    12901 gattatcttt cgataaaatt ccgtaaattt cttcgatact tacatccaaa ttttccaata
    12961 tacaaagaaa acgagaaagt gaaatctcag actcgccacg ttcaaactta gataaaaacg
    13021 aaaccgaaag ataatcacca gcaacatctt ttaatgaaag tttttttgat aatctaattt
    13081 ttttcgttaa agaacctatg tcaatagtat caatcataaa ataactcctt ttatacaatt
    13141 ataacaaaaa acgcaaacat aatgcagtct gcgttaacct tttgaatatt aggagtatat
    13201 gtaatacgaa gtctatcttt aaattcaaaa gaatcacttg gtaaactgtt caaaatttga
    13261 ataatcattt ttctccttaa aaacttggac agtaaatcgt aatacggatc ttatccattg
    13321 gaactgcaat tgttcctggt aacttattta ggttttgagt agtcattttt ttctcctttc
    13381 taaatcttat agacagatta tatatttttg caataattaa gtattaatat tttcatatat
    13441 aggaattgcc cgatactgtc aataattatg tgtaaacact caagtagagt tgaagaatgt
    13501 taatcaaata agctttcaag tgtgtca
//
