LOCUS       c00007_JAFIWH0..       17523 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAFIWH010000069.1 Streptococcus thermophilus strain 252
            NODE_16_length_44319_cov_83.462637, whole genome shotgun sequence.
ACCESSION   JAFIWH010000069
VERSION     JAFIWH010000069
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 00:31:31
            Original ID  :: JAFIWH010000069.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 26796
            Orig. end    :: 44319
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17523
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[36796:38683](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11887)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     cand_cluster    1..17523
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17523
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     CDS             complement(332..1336)
                     /locus_tag="ctg7_31"
                     /transl_table=11
                     /translation="MKEIFLQISNRQDLSQDQVQAVFDRILKNEVSENQIASFLMGLKI
                     KGETSDEITGIVRALKSHATVLPVTFTDAMCNCGTGGDQSYSFNISTTACFVLAAGGIR
                     MAKAGNRSISSKSGSADVLEVLGINVAASPEILSKALDEVGLAFIFAQTMHPAMRFIGP
                     ARQALGIPTIMNLVGPLANPLDLETQLMGLYRVELQEIVANAIQQLGRKRAAIITGPDN
                     MDEAALYGTNTYTLLEDGHISQHTFTYEDLGMEKVELSDITGGDAKENAEILLSVLRNE
                     DSPYLETTVLNAGLGFFANGKAGTIKEGVELARQLIADGSALEKLRKLQEVQV"
     CDS             complement(1427..1993)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249:carbamoyl phosphate synthase small subunit
                     (Score: 123.3; E-value: 1.8e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_32"
                     /transl_table=11
                     /translation="MILLVDNYDSFTYNLAQYLGTFTEVKVLRNDDEKLYEEAEKADGL
                     VFSPGPGWPADAGKMEALIKDFAGKKPMMGICLGHQAIAETFGGKLGLAKNVMHGKQSN
                     ITFETPSPIFKDIDNDVPIMRYHSIVVDQMPEGFDVTAITTDDQEIMAIQHKELPIYGL
                     QYHPESIGSPNGLKMVENFVKIVAG"
     CDS             complement(1990..3345)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 315.4; E-value:
                     1.4e-95)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_33"
                     /transl_table=11
                     /translation="MRKILPADTLTPILAYMRVQGEHKVILESIPREKENARFSIIAYN
                     PVFEVTFKDGVLYENGKAIDQDPFEYLDQVTVKGIKSDLPFAGGAIGFAGYDMIGLYEN
                     IGEIPEDTIGTPDMHFFIYESYLIFDHKKEKVYVVEDNIYSSRDNDAVRQALGQVVTIL
                     QTQAPNEFTPQALQALQFSNHIEKEVFTDMVAQAKKLIREGDMFQCVLSQRFSADFEGD
                     PLDYYRNLRVTNPSNYLYFYDFGDYQVIGASPESLVSVKNGEVFTNPIAGTRPRGANEA
                     EDAALADELSHDVKETAEHRMLVDLGRNDIGKIAKNGTVKVTKYMEVEYFRYVMHLTSV
                     VKGQLLPELTSLDALKSTLPAGTVSGAPKIRAMRRIYELEQEKRGIYAGAIGYLSATGD
                     MDFAIAIRTMILKNQKAYVQAGAGVVYDSVPENEFYETINKAKAMTRIGDVQ"
     CDS             complement(3422..3703)
                     /locus_tag="ctg7_34"
                     /transl_table=11
                     /translation="MDALNDIRSDIDNIDSQLIRLLAQRQILVEKAGRLKPKGDRSAVR
                     ANDRVVQVIANRRKEALELGLSPDVAESVWRSMIQVFIALEEKVNKEH"
     CDS             complement(4298..4648)
                     /locus_tag="ctg7_35"
                     /transl_table=11
                     /translation="MKIIGHLTPKVIKAFNLDYKPGEDITLSAQRKKHMEKHRQEFSDF
                     DAIYERIPEIIAHPDYIGRHPDGQSLEYIKRIDGNVLVAVTLCDKLNVRTMFVIKDSKL
                     KNYLNAGRAKKM"
     CDS             complement(4730..7090)
                     /gene_functions="other (smcogs) SMCOG1037:heavy metal
                     translocating P-type ATPase (Score: 410.2; E-value:
                     2.9e-124)"
                     /gene_kind="other"
                     /locus_tag="ctg7_36"
                     /transl_table=11
                     /translation="MKVVKKQLQGLTQMEVKQRIDDGKTNYFKAKAGSSNWDIFRRNVF
                     NSFNMLNFAIFVALIAVQAWSNLFFFGIIVLNAFTGMMTELRARRMVDKLNLMNQDKIR
                     VVRDGQLVSIDPKDIVLDDIMLLSAGEQVPSDAVVVDGMAELNEAMLTGESDQILKKDG
                     KELLSGSYLVSGQVYAKVINVAEDNYANKLMLEAKTHKPIVSCILYNMDKIAKFTGKIV
                     IPFGLALFFEAYMIKQLSLQESVVTSSTALLGMLPKGITLLTITSLLTAVIKLGMKHIL
                     VQEMYSVETLARVDVLCLDKTGTITQGKMTVKGLELLSERFTKEELERLLAAYMQHSKD
                     NNATAQAIRNAYEGLEHHYQVGDVIPFSSNRKWGAVSINGLGTLFLGAPEMLLKKNPKA
                     VDKAQARGSRVLILAWSQSGIATETMILPNDIEALTLLEIADPIREDAAETLEYLRSED
                     VTLKIISGDNPVTVSHIAHQAGFADYQSYIDCSKVSDEELEALAEDTAIFGRVSPHQKK
                     LLIQTLNANGHTTAMTGDGVNDILALREADCSIVMAEGDPATRQIANLVLMDSEFKDIP
                     EILFEGRRVVNNIAHIAPIFLIKTVYSFLLGLICIGSIVFGKAEYLLVFPFIQVQMTLA
                     GQFIEGLPPFVLTFERNIRPVEKHFLRRSLQLAIPNALMLVISVLIFHLSQVYLGMSST
                     DMLTLSYYMMGSMGVLAVIRACIPLNKGRVALIIYSVFGFLISSYYLRDVIAISTLNSY
                     TLPIYLVAMAICTPLFFWISYKQGAFQKAQSKT"
     CDS             complement(7351..7746)
                     /locus_tag="ctg7_37"
                     /transl_table=11
                     /translation="LEIEKEREDDNAKKKYFRDVGLLIVLCMSLYTYCNLKFNSVYYAQ
                     HIPHKEETETDLVMLVKNVGWIYTPKIDNIIYDDGTNDIINTKSKSFLTKSLGNFLYDK
                     DNMTVGFNSTFRFEDVSYFSEEAKKSS"
     CDS             complement(8162..8485)
                     /locus_tag="ctg7_38"
                     /transl_table=11
                     /translation="MEMSISFRTNTAMTNIAHNNSDLSDEEFKEEAHRHINKELIKDNI
                     VIKQESIKDVYEREFGEVLEHYNLKQTILSTSSPQTYKKEAFKPLFLSFKHSVTVHLLS
                     NIM"
     CDS             complement(8740..9963)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 79.2; E-value: 4.9e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg7_39"
                     /transl_table=11
                     /translation="MKVLLKNSVFRVVTLSRLVSSLGSYIYNIVFIIYATTLPYANMAV
                     FIANIVTVIPTLFTFWIGVKADRTENKAKKLVLAGFIQAILFTIIALLIKNKAFTVFAF
                     IGFLNVVSDVLSDYTNGLRLPIIQKNVDSAQLYEAYSISQVISYFSSIAGQSLGIWLLT
                     TSNNNYSFVAIINSLTFLVSSIVLLKNIQKLTYNQLESSVEKISLIKQFKEMYSSMEEV
                     FTKIDSTSSFLKIMASILVLNAIGGAVPSIYNFYFMKQPFFHLNYGHSLIVVQATLIIG
                     AIWGSLTPHDYFSKFSISKLIQTQGIAFALVGLSNVLQLPSIVGVIFLTFAAYIMGKAS
                     PKLDALLMENLPSEILAQSNNFIGLLFTLSLPVGVSIFSFLALYNIMFCWGLLTMLSVL
                     SLIFISQR"
     CDS             complement(10001..11887)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_40"
                     /sec_met_domain="LANC_like (E-value: 4.4e-10, bitscore:
                     30.4, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.1e-11, bitscore: 36.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIFFQNMVLKYIFQGHYKTTRKFFLQYSPFLTSNKIAAKYLKDQ
                     ESVLDNLSDMEQPAESGKLITIYPKDKEHCLYLLDTLYELLPNNLEGVYILSDRNYKKS
                     NVLFYRYGLIQPKNKKTIDSIPTLVGPNGEQWEDFQKCYFDLPSWVDDLQETQILTSSY
                     LSENYVVDSVLKQSNGGNVYKAIHLNSNKYVVIKECRQHIICTFETNKKQFRENEWNLS
                     SLVEDYAPSKNEKIKEWVNDYYVYEYIHGQSLLNFCDKLNLFSYETERYEQNINKFNKL
                     LLCFSKILETVRYFHSKNIVLNDIHSDNFIINDKENVVFIDLENSYIGGSTPLVGVYSD
                     IALREWNDVDGFIADCHKVGNLFLYLLGRLQIKDHTILTAELKNLLLQKGIESNIGRLI
                     NYLLSEDANIEKASEIMRKEVYAHTSKLNYKLNLESIDSEQWNKEIIKIVSLQETLIKK
                     YRSILEHPKNILVKLKSEVNLGLDGVAGVLLYLSSISYDKDVIEEGIDYVLSNMVKDSN
                     GHKGIQINEYSISPYLSNGTAGIIHLLMYVDPVKYNPAILELANALTFEFAQFSGIWNG
                     MLGISITLLQLFKLTKNKVYLKKAQELFISCKILSQRNMKLRKELLYVTHNI"
     CDS             complement(11902..12132)
                     /locus_tag="ctg7_41"
                     /transl_table=11
                     /translation="LKSVFYFIFFRIRKVSYEETNYNKKYIDGGDFKMKSYFESKFESY
                     IENKVKEIMDNPNKHPNIKIIYGEDYDPEEL"
     CDS             complement(12170..12259)
                     /locus_tag="ctg7_42"
                     /transl_table=11
                     /translation="MTQFAYEASKKSEPTKEFTLTYRCPIAQG"
     CDS             complement(12451..13308)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_43"
                     /sec_met_domain="TIGR01716 (E-value: 3.9e-38, bitscore:
                     122.8, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYMGEIFKTLRTSRNISLKEATGNEFSHSMLSRFENGESDITIT
                     KLLIGLKNIRTELSEFSYLINGFKSSSYSLLKKDIWNAISSNQLSVLNQLYMKELEEYR
                     THLKDVSFLNALIVKSHMLFLDENVIMTKEEESFLYNYLFSVEIWGEYELTVFSDVSVL
                     LPIDLYMRYTRKMMKRVDFLGELRKNKNLIHSILLNGLFKSTQEKQLVTAAYFDKMIKK
                     NFFEENDAYLRIVYMIADGQHLYCMGEKKRGLEQINEAIKILRILGCDESATYYSNNLK
                     EWSK"
     CDS             13839..14201
                     /locus_tag="ctg7_44"
                     /transl_table=11
                     /translation="MRKIIGILLLSISIITLISCSKNNYQSLEGEYYWISSERNELAFT
                     LKGNNASVEHGEADSFTINKQKNTIELTGQNIASRTEEYSFKDGVFSVDISGVKHDYYL
                     KGSEAYKKALKQYGYK"
     CDS             14484..14675
                     /locus_tag="ctg7_45"
                     /transl_table=11
                     /translation="MIIEYLNKNDTVLDPFLGSGTTCVVANSFGVNSIGIELNENYYTL
                     CKNIIKESTNEQLNLFNF"
     CDS             complement(14888..17479)
                     /locus_tag="ctg7_46"
                     /transl_table=11
                     /translation="LCLHNLFYTTLIYKEGEYRKYKREEEMNNKNNLEAQRAYRKISNE
                     KNKFGSYRKTLFHVHTPESHDYRLFKKWKDLPENDWNNLTIDDYIKEIRNQKIFPKDFL
                     QTYKGEKVLYGNYLMNGFSSEKEQVAFLTMAQSLYNENISVVVVSDHNTISGIEKLKTA
                     IKLVSDLFQNKCKEYIEVINGVEISCADKVHVLVAFPNSKASFIQKWLNFNLMSIKEGS
                     FKASLEVLEKFIYKDCFAYIAHMNSSDVFKEGHFSNAYKKKLFSKAYARFIGVSNIAKI
                     DDINSYLTKYLKKNVPSFILDNDSHCVEEHSINPMWIKFSKRNYEQLREALSEYDVSIE
                     LMNPEISKAKAIRGIYVPTLSNSYLLKNNSEFVIKFSESLNCLIGGRGTGKSTILDLIQ
                     FVLSQKADTKQKFEFLSQHSRVYILYEMSKKEYLVELNLPTQKNEEDIYDTFDVKTKST
                     SSYWYYESRLTEKIREQYLSIYEVQESGQLSKVSKQKKLSLIDKMFDNRYSVNQLVNIA
                     SDDRISDYLYEVIAKDKKSIKKYQVSSKISSTGEIDQFILNEDKRLEEQKNKILSLISP
                     FNDNQSGKLQILYSQQKKFVLPENFYFWFFPEGKNLDNSFQGYRLTCGEIIDYFSMIFD
                     RSGFVTFVDLMNNRNLKGEYSIKKFAQNSRLNDDVYRKEADDMLLNEIFELWNKVNINL
                     IQLYLEDVYNNCENLYLEFNINSKVTDGNKKIIFKEVTRLSLGQKVVAMLDFILAYSEF
                     TNDNRPLLIDQPEDNLDSRYIYNNLVQILRDVKNKRQIIIATHNATIVTNAMSDLVILM
                     ESDGEHGWVEQSGYPSDDKIKKHIVNYLEGGKELFEHKVKIYKRVIDINKL"
ORIGIN
        1 ttagccaagg ttggaatcgc tacctgtgtc gaaatttctt tcaaatagga aatatcacct
       61 ttgaagaaga cttcgtcagt caaaactgaa atcatggctg ccccattttc ctcatagatc
      121 ttggactgag ctacaatatc cacatctagg ttaatatcac ccatacttgg actggctttc
      181 ttcacttcag aaataatttg caacttgttt tgatttgact tgagaaaatc ataaaggcga
      241 taggtctgac gcaagggctg taagtcttcc atgaccaact gggccacttc tttttctttt
      301 tgttctagga ttgttggaag aaaagcttta ctcatacttg tacctcttgg agtttgcgaa
      361 gtttctctag ggctgatccg tccgcaatta attgacgagc aagctcaaca ccttctttaa
      421 tggtcccagc cttaccattg gcaaagaaac caagacctgc attaagcact gttgtttcaa
      481 gataaggact atcttcattt ctcaagacac taaggagaat ctctgcattt tccttggcat
      541 caccacctgt gatatcagac aactcaacct tttccatacc cagatcttca taagtaaagg
      601 tgtgctggct gatgtgacca tcttccaaaa gggtgtaggt gttagtacca tagagagcag
      661 cttcgtccat attgtcagga cctgtgataa tagccgcacg ttttcttccc aactgttgaa
      721 tagcattagc aacaatctct tgcagctcca cacgatagag ccccatgagt tgcgtctcaa
      781 ggtcaagcgg attagccagt ggtccaacca agttcataat cgttggaatc ccaagagctt
      841 ggcgagctgg accgataaaa cgcatggctg ggtgcatggt ttgtgcaaag ataaaggcca
      901 aaccaacctc gtcaagtgct ttagatagga tttctggtga tgccgcaacg ttgattccaa
      961 ggacttcaag gacatctgcc gaaccagatt tagaggaaat cgaacggtta ccagccttag
     1021 ccatacgaat accacctgct gctaggacaa agcaagccgt tgttgaaatg ttaaagctat
     1081 aagactggtc tccaccagta ccacagttac acatagcatc tgtgaaggtc acaggcaaga
     1141 ccgtcgcatg tgatttgagg gcacgcacga tacctgtgat ttcatctgat gtttctccct
     1201 taattttaag ccccataagg aaggaagcga tttggttttc tgagacttca tttttgagaa
     1261 tacggtcaaa gactgcttgg acttggtctt gagacaagtc ttgtcggttt gagatttgta
     1321 gaaatatttc tttcatatct gttttccttc taaagacggt tcaatatttt ccgatgcacg
     1381 gggagatgtt ttgagcctag atttatctag tcaaaagacc aaccaactag cccgcaacaa
     1441 ttttcacaaa attttcaacc atcttgagac catttggact tccgatgctc tctgggtgat
     1501 attgcaaacc ataaattggt agctccttat gttgaatggc catgatttct tgatcatcag
     1561 ttgtgatggc tgtcacatca aagccctctg gcatttggtc aacaacgatg gaatgataac
     1621 gcatgattgg gacatcattg tcaatatcct tgaaaattgg cgatggcgtt tcaaaagtaa
     1681 tattgctttg tttgccatgc atgacattct tagccaagcc aagtttacca ccaaaagttt
     1741 ccgcaatagc ctggtgcccc aagcaaattc ccatcatcgg ttttttacca gcgaaatcct
     1801 taatcaaggc ttccatttta cccgcatcag ctggccaacc tggacccggt gaaaagacta
     1861 gcccgtcagc tttttccgcc tcttcataga gcttctcatc atcgttacgt aagactttca
     1921 cctctgtaaa tgtccctagg tattgtgcca aattataggt aaaagaatcg tagttatcaa
     1981 ctagtaaaat cattggacat ctcctattct tgtcatagct ttcgccttat taatcgtttc
     2041 ataaaattca ttttcaggaa cactgtcata gacaacacct gcacccgctt gaacataggc
     2101 tttttgattt ttaagaatca tggtacggat agcaatagca aagtccatat ctcctgttgc
     2161 agacaaataa ccgatagctc ccgcgtaaat accacgtttt tcctgctcaa gctcatagat
     2221 acgacgcatg gcacgaatct taggcgcccc ggacacagtt ccagctggta gggttgactt
     2281 tagagcatca agggacgtca actccggtaa gagttgcccc ttaaccacac tagtaaggtg
     2341 catcacatag cggaaatact caacctccat atacttggtc accttgaccg taccattttt
     2401 ggcaatctta ccaatatcat tacgtcccaa gtcaaccaac atacggtgtt ctgcagtttc
     2461 tttaacatca tgtgagagtt catccgccaa ggcagcatct tcagcctcat tggcaccacg
     2521 agggcgagtt ccagcaatcg gattggtgaa cacctctcca tttttcactg aaaccaggct
     2581 ctctgggctg gcaccaatca cctgataatc tccaaaatca tagaaataaa ggtagtttga
     2641 tgggttggtc acgcgcaagt tacggtagta atccaaagga tctccctcaa agtccgctga
     2701 aaagcgttga ctaagcacac attggaacat atctccctca cgaatgagtt tcttagcctg
     2761 agccaccata tccgtgaaga cctctttttc gatatgattc gaaaattgca aagcttgcaa
     2821 ggcctgaggt gtaaactcgt ttggcgcctg agtctgtagg atcgttacca cctgaccaag
     2881 agcttgacgc accgcatcgt tgtcacggct agagtagatg ttgtcctcaa ccacataaac
     2941 cttttccttc ttgtgatcaa aaatcaaata agactcatag atgaagaaat gcatatcagg
     3001 tgtcccaatc gtatcttcag gaatctcccc gatattttca tagagaccaa tcatatcata
     3061 acctgcaaat ccgatagcac cacctgcgaa aggtaggtca gacttgatgc ccttgactgt
     3121 tacttggtcc aagtattcga aaggatcctg atcaatcgcc ttaccatttt cataaagaac
     3181 accatccttg aaggttactt caaagaccgg attgtaggca ataatagaaa aacgtgcatt
     3241 ttccttctca cgaggaatag attcaaggat aaccttgtgt tccccttgaa cacgcatata
     3301 agccaagatt ggtgttaagg tatcggctgg taaaattttt ctcatagtat ttcctttcaa
     3361 actggtttat cgagagtaat aagactgata caagactcct ttataggata tatcggcacc
     3421 attagtgttc tttgttcact ttctcttcca aagcaataaa gacttgaatc atgcttcgcc
     3481 aaacactttc agccacatct ggcgataagc caagctctag tgcctccttg cgacgattag
     3541 ctatgacttg aacaacacga tcattcgccc ggactgcgga cctatctcct tttggcttca
     3601 gccgccctgc cttttccaca agtatttgac gttgggccag gagtcgaatt aactgactat
     3661 caatattatc aatatcactt cgaatatcgt ttaatgcatc cataataccc aacctttcat
     3721 tgaataatga aataatactc ctttaaggta aatagatctt taaagataaa agtaaccaaa
     3781 aagcctcaca gagaaaaact ctgtgagggc attaaatcta gtttaacacg gtaccacctc
     3841 agttaatggt ctccaaaaaa acgaccatca tctctatctc ctctatcaag gagttgcacg
     3901 gtaaggggtg ccaaccgaga agaatatgtg ttaccttctc attatcatcc aatcagccca
     3961 atgttcactc atctcgatta cctactcaca atcaccacag gctccctgaa aatctaagac
     4021 cagttacttt ctgatttact aactattgta ctccttttta aaaatatgtc aagaattttc
     4081 tgttaatttt gacaattctt ctcctatagg attagtctat acctaatcca gatagtgaga
     4141 tagccttgcc cctaagctac acaaaataaa aaagcccccg aaagggactt cttgggttga
     4201 taaacaacgg cagggtgaca gtcctgcatc tctttcagac ccgaaggtgc ggcggctacc
     4261 tcttccgctc tcgttgttat tccttaccca tgttatatca cattttcttc gctctaccag
     4321 catttaggta gtttttcagc ttagaatctt taatcacaaa catggtacgg acattaagtt
     4381 tatcacataa tgtaaccgct actaaaacat taccatcaat acgtttgatg tattccaagg
     4441 actggccatc aggatggcga ccgatatagt ccggatgagc aataatctct ggaatacgtt
     4501 catagatggc atcaaaatca ctaaattcct ggcgatgttt ttccatatgc ttcttacgtt
     4561 gtgcagacag cgtgatgtct tcaccaggct tgtagtctaa attaaaagct ttaatgactt
     4621 ttggcgtcaa gtgccctatt attttcatgc ctttattgta acatacctaa tgcccatcaa
     4681 ggattttcct attatttagc tatcaaaaaa ctaaagtctg ttagcaagct taagttttgc
     4741 tttgtgcttt ttggaaagca ccttgtttat agctaatcca gaagaaaagc ggtgtacaga
     4801 tagccattgc gaccagatag attggcaatg tgtagctatt aagtgttgag attgcaatca
     4861 catctcgaag atagtaggaa ctgattaaga agccaaagac tgagtagata atcaaggcca
     4921 cacgcccctt attcaagggg atacaagcac gaataacggc aagaacaccc attgatccca
     4981 tcatataata agaaagcgtc agcatgtctg tactactcat accaagatag acctgagaca
     5041 gatggaaaat aagaacactg ataaccagca tcaatgcatt aggaatagcc aactggagcg
     5101 aacgtctgag gaaatgtttc tcaacaggac gaatattacg ttcgaaggtc aaaacaaatg
     5161 gtggaagacc ctcgataaac tgacctgcca aggtcatctg aacctgaatg aatggaaaga
     5221 ccaagaggta ctccgccttt ccaaaaacaa tactgccaat acagataagc cccaaaagga
     5281 aggaataaac agttttaatg aggaaaatag gtgcaatgtg ggcaatatta ttaaccacac
     5341 ggcgtccctc aaatagaatt tcaggaatgt ccttaaactc agaatccatt agcaccaagt
     5401 tagcaatctg gcgtgtagcc ggatctccct ctgccataac aatcgaacaa tccgcctcac
     5461 gcagtgccaa gatatcattg acaccgtcac cagtcatagc cgtggtatgc ccattggcat
     5521 taagggtttg gattaataac tttttctgat gcggagatac acgaccaaaa atcgcagtat
     5581 cctcagccaa agcctccaac tcctcatcac tgaccttaga acagtcaata tagctttgat
     5641 aatcggcaaa accagcttga tgagcaatat gagaaaccgt cactggattg tcaccagaaa
     5701 taatcttaag tgtcacatct tctgaacgca ggtattccag agtttctgca gcatcctcac
     5761 gaataggatc ggcaatttca agcaaggtca aagcctcgat atcattcggc aaaatcatgg
     5821 tctctgtggc aatacctgac tgactccaag ccaaaatcaa aacacgagac cctcgcgcct
     5881 gagccttatc gactgcttta ggattcttct taagaagcat ctcaggtgct cccaaaaaga
     5941 gagttccaag cccattgatg ctcacagcac cccatttacg attgcttgaa aatggaataa
     6001 catcacctac ctgataatga tgttccagac cctcataagc atttcgaata gcctgagctg
     6061 ttgcgttgtt atccttgcta tgttgcatat aagccgcaag caaacgctcc aactcctctt
     6121 tcgtaaaacg ctctgacagt agctctagac ctttaactgt catctttcct tgtgtaatcg
     6181 tccctgtctt atctaaacaa agcacatcta cacgggccaa ggtttcaaca gagtacatct
     6241 cttgcacaag gatgtgtttc atcccaagct taatgacagc cgtcaaaagt gatgtaatag
     6301 tcaaaagggt aattccctta ggcaacattc ccagaagggc tgttgaactg gtaacgaccg
     6361 actcttgaag agaaagctgc ttaatcatgt aagcctcgaa aaagagtgca agcccaaacg
     6421 gtataacaat ctttcccgta aacttagcaa tcttgtccat gttataaagg atacaggaca
     6481 cgattggctt atgagtcttg gcctctaaca taagcttgtt ggcgtaattg tcctcggcta
     6541 cgttaatgac cttagcatag acctgaccac tcacaagata agaacccgag agcaactcct
     6601 tcccatcttt ctttagaatc tgatcactct caccagtcag catagcctcg ttaagctcag
     6661 ccattccatc aacaaccact gcatcactgg gaacctgctc acccgcagac aagagcatga
     6721 tatcatctaa gacaatatcc ttaggatcga tggaaacaag ctgtccatca cgcaccacac
     6781 gaatcttatc ctgattcatg agattgagct tatcaaccat gcgacgggca cgcaactccg
     6841 tcatcatccc tgtaaaggca ttaagcacaa taatcccgaa gaaaaataga ttagaccaag
     6901 cctgaacagc aatcaaggcc acaaagattg caaaattaag catattaaag gagttgaaga
     6961 cattacgcct aaaaatatcc caattgctgg agccagcttt tgctttaaaa taatttgttt
     7021 taccgtcatc tatccgctgc ttgacctcca tctgagtcaa gccttgtaac tgttttttca
     7081 caactttcat agtagcataa aaacaaggta ttttcaaagg ttagccgtca tgaataccaa
     7141 gtaaataaac ctattacccc tcatgctttt ttcactctgc catccagacc aataaaccca
     7201 acaaaaatat tctgtaggat tatattctct aattaaacct acttcggtaa agtagattaa
     7261 acaaccattg aagattgata aaaggttttg tatgaacctt catgattgat gaaaaaatct
     7321 tccttaatct ctcgtttaat ttgtgattca ttaacttgat ttttttgctt cttctgaaaa
     7381 ataactgacg tcctcaaatc taaacgtact attaaaacca acagtcatat tatccttatc
     7441 atataaaaag tttcctaagg attttgttag aaaagattta cttttagtat ttataatatc
     7501 gtttgttcca tcatcatata taatattgtc gattttagga gtataaatcc accccacatt
     7561 ctttaccaac ataactaaat ccgtttctgt ctcctcctta tgagggatat gctgagcata
     7621 ataaacagag ttaaatttta aattacaata agtatagaga ctcatacaca agactataag
     7681 cagtccgaca tccctaaaat atttcttttt tgcattgtca tcttctctct ccttttctat
     7741 ctccaattac atgttgacta ggttaacaat taagcattgt acactattca taacaattct
     7801 taaaactcaa tgatttgtgg cttctgtaat tgcttctaca gctttttaac aaagcctcgt
     7861 gataccatcg ttgtaaacaa acttaactct cttataatta cggattctct ttgaccctct
     7921 ctcactttgt cattcaaact aaacatggta taatagttta ggtatcgact gtctcttcta
     7981 ttaggaaaaa taaggcatca aaaagtaaca agaaggggct aaacccttga tatgaaagga
     8041 atctagaaat tattatgatg aacatgcaag acttaattta agattcttta agtcttgata
     8101 tcattagaaa tcttgatttt aaaggcttta gagttcaaaa aattaacgat attcaataat
     8161 attacattat attggacagt aaatggacag tgacagagtg tttgaaggag agaaaaagag
     8221 gcttaaatgc ctctttttta tatgtttgtg gactagaagt agatagaata gtttgcttta
     8281 ggttataatg ctctaaaact tctccaaatt ctcgttcata gacgtcttta atactttcct
     8341 gcttaataac aatattgtct ttaattaact ctttatttat atgcctatga gcttcttctt
     8401 taaattcttc atcactcaaa tcactgttgt tgtgagcaat attcgtcatc gctgtatttg
     8461 tcctaaatga aatactcatt tccatcacaa ataaaacctc ctccctcttg tccgaatcgc
     8521 agacaaagtg caagccgcaa aagctattgc ttgcactatt agctagaata agatttttaa
     8581 ttttattcta gcttttctgt tactctttgt caaagagtaa acgtttttgt agttttgaca
     8641 ctatggatca aaacacaaat gttctccgag gggtcttgta gacgtcaatt gtgcgaatca
     8701 acgcacaaaa aattctccct atactaggga gaatacctat tatctttgag aaataaatat
     8761 tagagagagg acggataaca ttgtgagaag cccccaacag aacatgatat tgtatagtgc
     8821 taaaaatgag aagatagaaa cacctacagg gagtgacaaa gtaaaaagaa gtccgataaa
     8881 attattactt tgcgctaata tttccgatgg taaattttcc attagaagtg cgtcaagttt
     8941 aggagaagcc ttccccataa tatatgctgc gaaagttaag aagataaccc caacaataga
     9001 tggtaattga agtacattag acagaccaac taaagcgaat gctattcctt gagtttgtat
     9061 taattttgaa atagaaaatt tagaaaaata atcgtgagga gttaagcttc cccaaattgc
     9121 ccctataata agagtagctt gaacaacaat taaagaatga ccataattta gatgaaaaaa
     9181 tggttgtttc ataaagtaaa agttataaat actagggact gcaccaccaa tagcatttaa
     9241 tactaaaatt gaagccataa ttttaagaaa agaagatgta ctatcaattt tagtaaatac
     9301 ttcctccatg ctactataca tttctttaaa ttgcttaatt aatgagattt tttctacaga
     9361 actctctaac tgattatacg ttaacttttg tatatttttt agaagaacaa tagatgatac
     9421 caaaaaagta agggaattaa taatagcaac aaaagaatag ttattgtttg atgtagtaag
     9481 taaccaaatt cctaaacttt gtccagcaat gctagagaaa taggagataa cttgtgatat
     9541 tgagtaagcc tcgtatagct gggcagagtc aacatttttt tgaataattg ggagacgcaa
     9601 accatttgta taatcactaa gtacatctga tacgacattt aaaaatccta taaaagcaaa
     9661 gacagtgaag gctttatttt ttatcagtag agctataatc gtgaataaaa ttgcctgaat
     9721 aaatccagct agaacgagtt ttttagcttt attctcagtt cgatctgctt ttacccctat
     9781 ccaaaaagta aataaagttg ggataacagt aactatatta gcaatgaaaa ctgccatatt
     9841 tgcataagga agggttgtgg cataaattat aaaaacaata ttataaatat atgaccccaa
     9901 tgaactaact aacctagaca aagtaacaac tctaaaaact gaatttttta ataatacctt
     9961 cattttctcc ctacaatcct ttctaagtag accgaacttg ctaaatatta tgtgtaacat
    10021 ataggagttc ttttcgtaat ttcatattac gttgcgacaa tattttacaa ctaataaaca
    10081 attcttgagc cttcttaaga tatactttat tttttgttaa cttgaataat tgcaataaag
    10141 taatggatat ccctaacata ccattccaaa ttccactaaa ttgggcaaat tcaaatgtta
    10201 atgcatttgc caattctaga atagcgggat tatatttcac aggatccacg tacattagta
    10261 aatgaataat tccagctgtc ccatttgata aatacggaga aatagaatat tcatttattt
    10321 gtatcccttt gtggccatta ctatctttaa ccatattact taaaacataa tcaatcccct
    10381 cctcgataac atccttatca taagatattg aagaaagata aagtaacact ccagcaacgc
    10441 catctaatcc tagattgact tctgatttta atttaactaa aatatttttt gggtgttcta
    10501 atatagagcg atacttttta attaatgttt cttgcaaaga aacaatttta ataatctctt
    10561 tattccattg ttcagagtct attgattcta agttcagttt atagttcaat ttagaagtat
    10621 gagcgtaaac ttcttttctc ataatctccg atgccttttc tatatttgca tcttcactta
    10681 ataaataatt aataagtcta ccgatattgg attcaattcc tttttgtaac aatagatttt
    10741 ttaattcagc agtcaagata gtatggtctt ttatttgtaa tcttcccaac aaatacaaga
    10801 ataggttccc tactttgtga cagtctgcaa taaaaccatc tacatcattc cattctctta
    10861 atgcaatatc tgaatagact cctactaaag gagtggatcc tccaatatag gaattttcta
    10921 aatcaataaa caccacattt tctttatcat tgataatgaa attatcagaa tgaatatcat
    10981 tcaatacgat attcttacta tggaaatatc tcacggtttc tagtatttta gaaaagcaaa
    11041 gcaataactt attaaactta ttaatatttt gctcatatct ctcagtttca taggaaaata
    11101 aattgagctt atcacaaaaa tttaataaac tttgtccatg tatatattca tatacatagt
    11161 aatcatttac ccattcttta attttctcgt ttttggaggg agcataatcc tctactaaac
    11221 tagacaagtt ccattcattc tctctaaatt gctttttatt agtttcaaaa gtacaaatga
    11281 tatgttgacg acattctttt ataactacat acttattaga atttaaatga atagccttat
    11341 aaacatttcc accattagat tgttttaaaa cactatctac tacataattc tcactcaagt
    11401 atgatgatgt taatatttga gtttcttgca aatcatcgac ccaagaaggc aagtcaaaat
    11461 aacatttttg aaaatcttcc cattgttccc catttggacc tactagagtt ggaatactat
    11521 cgatagtttt cttgttttta ggttgaataa gtccatatct ataaaaaagg acatttgatt
    11581 ttttataatt tctatcacta agtatgtaaa caccttctaa gttattgggc agtagttcat
    11641 atagcgtatc taacagatac aagcaatgtt ccttatcttt gggataaata gtaatcaact
    11701 tgccagattc ggcaggttgc tccatatcag aaagattatc taatacactt tcttgatctt
    11761 ttagatactt agctgctatt ttattagatg ttaaaaacgg ggagtactgt agaaaaaatt
    11821 tcctcgtagt tttgtaatgt ccctgaaata tgtattttaa aaccatattc tggaagaata
    11881 taatcataat tttctatata cttaaagctc ttcggggtca taatcttcac catatatgat
    11941 ttttatatta ggatgtttat ttgggttatc cattatttct ttaactttat tttctatgta
    12001 agattcaaac ttagattcaa agtagctctt cattttaaaa tcccctccat caatatattt
    12061 tttgttatag ttggtttctt cataactaac ctttctaatt ctaaaaaata taaaataaaa
    12121 aacgctcttc aattttttat tttagagcat ttttttattg ctagacattt tatccttgag
    12181 caattggaca tctataagta agagtaaact ctttagttgg ctcagacttt ttgctagctt
    12241 cataagcgaa ttgtgtcata tcgttaacct ccatttcatt ttatgtatat agtatacact
    12301 ctaaaattac aattaaaata aaatgtacgt attttcaact tataaaattg gaaaaaaaga
    12361 aaaagaatag ccgtttaaac ctgctattcc ttgaagttcc tcttctgtta aaatttttaa
    12421 aattaaatag tatagttgaa tttttgcaaa ctatttcgac cattctttta gattgttgga
    12481 ataatatgtt gcactttcat cgcaacctaa tatcctcaaa atttttattg cctcatttat
    12541 ttgttctaat cctctcttct tttcccccat acaatataag tgttgtccat cggcaatcat
    12601 ataaactatt cttagatagg catcattttc ttcaaaaaag ttctttttaa tcattttatc
    12661 aaaatacgct gcagtaacta attgtttttc ctgtgtagat ttaaataagc catttaataa
    12721 aatactgtga attagatttt tattttttcg aagttctccc agaaaatcta cccttttcat
    12781 catttttcta gtgtaacgca tatataaatc gattggtaat agtactgaaa catccgaaaa
    12841 cactgttaat tcatactctc cccatatctc tacagaaaat aaataattat agagaaaact
    12901 ctcctcttcc tttgtcataa taacattctc atctaaaaat aacatatgac tttttactat
    12961 taaagcgttc aagaaggata catccttcaa atgtgtacga tactcttcta actccttcat
    13021 ataaagttga ttcaatacag ataattgatt tgaggatatg gcattccaga tgtctttttt
    13081 taataaagaa tatgaagatg atttgaatcc atttataagg tatgaaaatt ccgacaactc
    13141 tgtccgaata ttctttagtc caattaatag ttttgttatt gttatgtcag attctccatt
    13201 ttcaaatcta ctcaacatag aatgagaaaa ttcgttacca gtagcttctt ttaaagaaat
    13261 attccttgat gtacgtaacg ttttaaatat ttcgcccata tatttcattt tttatacctt
    13321 atcctaaatt ttattaagcg caaaatctaa aattattaat aaattagaat ttctctcgtt
    13381 gctgatatat caactttatt ctagcgttcg ttattcaata aaattaaaaa tatctatata
    13441 ccatattttt gtttttttca aaaaacgatt attatctcgc acttttttgg tcattatact
    13501 actgaaaacc ggatactgtc aataattttg tgcaaacact ctagtagagt tatggagttt
    13561 taatgaaata ggctttcaag tgtgtcagga cattggccaa accctttatg gattcattga
    13621 ctttgtttga attatattct tcaaacaggg taactaagta acgttccagg gtagtaccgt
    13681 aattagtttt ttcttaatta tattcagtaa ataattatat tctgaatagt tattttctgt
    13741 tataatagac atttcttcat ttttccgtta taacagacac gacatactct tgtaatatta
    13801 ttttggtata attaaaatta tagaaggagg cacagattat gagaaaaata ataggtatac
    13861 tactactttc gatatcaata attacgttaa tttcttgctc taaaaacaac taccaatctt
    13921 tagagggtga gtattattgg atctcaagtg aaagaaacga gttagcgttt actcttaaag
    13981 gaaataatgc ttccgttgag catggagaag ccgacagctt taccattaac aaacaaaaga
    14041 atacgatcga attaactgga caaaatattg caagtagaac agaggaatat tcatttaaag
    14101 atggggtctt ttctgttgat attagtggag ttaagcatga ctactatctt aaaggtagcg
    14161 aagcgtataa aaaggctcta aaacaatatg gatataaata acatcattca cacctatttt
    14221 accgaatagg tgttttttgt gctgaataga ttacttcaaa gaacttttaa gcttattctt
    14281 aaccgaatag tttatatttc atgcaaatta gtttaatcaa agagattgga ttatatttta
    14341 ttatacaatg gattcatgaa taatttaaaa gaaacaaata tcagaaaagc tatttggcat
    14401 attagacgtc acctaaacga actattgaat tcacaagatg aaaaatatag aaaacatgaa
    14461 atgttccatc aaaaatccct agtatgatta ttgaatattt aaataaaaac gatactgtct
    14521 tagatccttt ccttggcagt ggaactactt gtgttgttgc taatagtttt ggtgtgaatt
    14581 ctattggtat tgagttaaac gagaactatt atactttatg taaaaacata ataaaagaaa
    14641 gcaccaatga acaacttaat ttatttaatt tttagagtag tatacaagct attctatcta
    14701 aattagtata atagatcatt gctctaaatt tagatatatc ttagtagttc attataaaat
    14761 ttaatattaa aaagagcctg ggacaaaatc gttctcaacc acaaaaagct agagatttcc
    14821 aattgcggaa ctctagcttt ttaattttga gtcgttctct tattctgaaa gttatacact
    14881 aaacatttta cagtttattt atatcaatta cacgtttata tatttttacc ttatgctcaa
    14941 acaattcttt gccaccttca aggtagttta caatgtgttt ttttatttta tcgtcacttg
    15001 gatatccact ttgttcaacc catccatgtt ctccatccga ttccatcaaa ataactaaat
    15061 cagacattgc atttgttact attgttgcgt tgtgagtggc tataataatc tgacgtttgt
    15121 ttttaacatc tcgtaatatc tgcactaaat tattgtatat atatcgtgaa tctagattat
    15181 cttctggttg gtctataagt aatggtcgat tatcatttgt gaattctgaa taggcaagaa
    15241 taaaatcaag catggcaact accttctgac ctaaacttaa acgtgttacc tccttaaaaa
    15301 ttattttctt gtttccatct gtcactttgg agttgatatt aaactcaaga tataaatttt
    15361 cacaattatt ataaacatcc tctaaatata gctgaattaa attaatatta actttattcc
    15421 agagttcaaa aatttcattc aataacatat cgtctgcttc ttttcgatat acatcatcat
    15481 tcaacctact attttgggca aattttttta ttgaatattc acccttgagg ttcctattat
    15541 tcattaagtc tacaaaagtc acaaaaccac ttctatcaaa aatcattgaa aaataatcga
    15601 tgatttcccc acatgttaaa cgatatcctt gaaacgaatt atctaaattt ttcccctcag
    15661 ggaagaacca aaaataaaaa ttttcaggta atacaaattt tttttgttga ctatacaata
    15721 tttgtagctt ccctgattga ttatcattga atggacttat tagtgataat attttatttt
    15781 tttgttcttc taatcgctta tcttcattca gaatgaattg gtcaatttct cctgttgaag
    15841 atattttact agaaacttga tattttttta tactcttttt atctttagct attacttcat
    15901 acaaataatc acttattctg tcatcactag caatatttac aagttgattt actgaatatc
    15961 tattatcaaa cattttgtct attaagctta atttcttttg tttggaaact ttactaagtt
    16021 gaccactctc ttgaacttca tatattgata aatattgttc tctaattttc tccgttaaac
    16081 gactttcata ataccaataa cttgatgtag attttgtttt aacgtcaaaa gtgtcatata
    16141 tgtcttcctc attcttctga gtaggtaaat ttaactcaac caaatattct ttctttgaca
    16201 tctcatacaa aatatatacc cttgagtgtt gagagagaaa ttcaaatttt tgtttcgtat
    16261 ctgctttttg agacaataca aattgaatca aatctaaaat cgtacttttt ccagttcctc
    16321 ttcctccaat taaacaattt agggattccg aaaatttaat aacaaattct gaattattct
    16381 ttagcaggta cgagttactg agagttggta catatattcc acgtatagct ttcgccttgc
    16441 tgatttctgg attcattagt tcaatggata catcatattc tgataaagct tctcggagct
    16501 gttcatagtt tcttttacta aattttatcc acatcggatt aattgaatgt tcctcgacac
    16561 aatgtgaatc attgtcaaga ataaatgatg gtacattctt ttttaaatat ttcgtaagat
    16621 agctattgat atcatctatt ttggcgatat ttgatacgcc tatgaatcga gcgtaagcct
    16681 tagaaaaaag ttttttcttg taagcatttg aaaaatgccc ctctttaaat acatctgaac
    16741 tattcatatg agctatgtag gcaaaacaat ctttatagat aaatttctcc aatacttcca
    16801 aactcgcctt aaaagatcct tccttgatac tcattagatt aaagttaagc catttttgaa
    16861 tgaaactagc tttactgtta ggaaaagcta ccagcacatg caccttatct gcacaagaaa
    16921 tttccactcc gtttattact tcaatatatt ctttacattt attctgaaat aaatcagata
    16981 ctaatttaat agctgtcttt aatttttcta tacctgatat agtattatga tccgagacta
    17041 caacaaccga tatattttca ttgtaaagac tttgagccat agttaaaaag gcaacttgtt
    17101 ctttttcgct actgaatcca ttcataagat agtttccata taaaaccttt tcccctttat
    17161 atgtttgaag aaagtctttt ggaaatattt tttgatttct aatctcttta atatagtcat
    17221 caatagttaa attattccaa tcattctctg gcaagtcttt ccatttttta aataatctat
    17281 aatcatgaga ttctggagta tgtacatgga acaaagtctt acgataactt ccaaatttat
    17341 ttttttcatt actaattttt ctatatgcac gttgtgcttc taaattattt ttattattca
    17401 tctcttcctc tcttttatat tttctatact ctccttcctt atatattagg gtagtgtaaa
    17461 ataagttgtg taaacacaaa aaggaataaa tccgttatag tagagttgca aaacattact
    17521 aga
//
