LOCUS       c00021_JACSUF0..        4084 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JACSUF010000028.1 Streptococcus thermophilus strain S72 202-S72-28,
            whole genome shotgun sequence.
ACCESSION   JACSUF010000028
VERSION     JACSUF010000028
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 00:40:05
            Original ID  :: JACSUF010000028.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4084
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..4084
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3083](-)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(3..3083)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..4084
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..4084
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(3..3083)
                     /NRPS_PKS="Domain: AMP-binding (194-561). E-value: 3e-68.
                     Score: 222.0. Matches aSDomain:
                     nrpspksdomains_ctg21_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (666-729). E-value: 2.2e-11.
                     Score: 35.9. Matches aSDomain:
                     nrpspksdomains_ctg21_1_PP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     212.4; E-value: 1.5e-64)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_1"
                     /sec_met_domain="AMP-binding (E-value: 1.4e-59, bitscore:
                     188.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 8.6e-13, bitscore:
                     35.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKLDLVRQYLDSEKITGTKIFYGSCIESHSDAKDVDVCVITNQT
                     VDEDFYHRYKKFLIENNIVIDEEVRYEDKLLLSESKISNAIKNYVNQPECFDLEADYPQ
                     VVDRLVVNILTTKVKVFDDNGVYDEYSNQAWEEVLKKFTSLGGNTFSDFTKLFQINQNY
                     KSFWGYSPKVVDDLFNRFYRYHSSNRAIRLLKENVIKHPQRIAVFSENRNLTYEELDKL
                     SDNIANKLLEFNSDYVVVNYPHTYELLPIVYGILKAGKIYIPVDNTSPLTEIEPIRKKF
                     KDSIYISENASDLAVSKALGMEHRLLDYSENELAYIIHTSGTTGVPKGVCVTKNNLNYI
                     LEACQYIAPVSSRDCYLFSTRDTFDVSITEIFGFLYNGGSVCVYSAKNKDFYKEFPDLI
                     EKFGITHVALSPSVLGLLLKLADQEDLRKIDKLKYLLVAGEEFKYELLKLVLKDLKKVN
                     VYNVYGPTETTVYATYFNVRNTPKKLQKVPIGENLPGVKTMLVKDELLIGGKGVSAGYF
                     NNAEQTDQKFEKIDGEVFYHTGDIVEKQDSLLVYRDRKDSQVQIHGIRVELGDIRANIS
                     NIIDDPTRDIEVVFYSDSLILFYTGTKISDLRTMLEKHMVSYKIPSKYINVKGFPLTSS
                     GKVDRKKLLSGMKESSISSNDSKKSGIGIYNTVKHIAESVMNQTVGSEENLLDIGLDSL
                     RSVELVLELEKRLNIDLSAFNIYMSPTVDKIASFIENMTTSPASKADKELFRENEIKNI
                     PITRKVEYTYPAFFYARIYNSLGFNSQLTGKIYLGKDSISYEEIYHKLSKVEVFKSVLS
                     EDLNTFKVLDTPVNISKYEVADARIDISKTLSDLVKTSIENGGLLYKFVLLEDENESVL
                     HYSIDHSICDSSSLDALERYILGIYDSSQTYSSYIEEVYSRNHLEEILKEMAKFEQQDD
                     RKVAETFKRLEDRVNFVSLTYLNNDTKNVYAEILLYLRDKLLKKFALNNVKVNLIYNIR
                     KFQEKLDFTTTIGDLHLGLTYSLTTDDDIDEQLTETIA"
     aSDomain        complement(897..1085)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg21_1_PP-binding.1"
                     /evalue="2.20E-11"
                     /label="ctg21_1_PP-binding.1"
                     /locus_tag="ctg21_1"
                     /protein_end="729"
                     /protein_start="666"
                     /score="35.9"
                     /tool="antismash"
                     /translation="TVKHIAESVMNQTVGSEENLLDIGLDSLRSVELVLELEKRLNIDL
                     SAFNIYMSPTVDKIASFI"
     aSModule        897..2501
                     /complete
                     /domains="nrpspksdomains_ctg21_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg21_1_PP-binding.1"
                     /locus_tags="ctg21_1"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(1371..1427)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg21_1_0003"
                     /evalue="1.10E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg21_1"
                     /protein_end="571"
                     /protein_start="552"
                     /score="21.1"
                     /tool="antismash"
                     /translation="DRKDSQVQIHGIRVELGDI"
     aSDomain        complement(1401..2501)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg21_1_AMP-binding.1"
                     /evalue="3.00E-68"
                     /label="ctg21_1_AMP-binding.1"
                     /locus_tag="ctg21_1"
                     /protein_end="561"
                     /protein_start="194"
                     /score="222.0"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="KENVIKHPQRIAVFSENRNLTYEELDKLSDNIANKLLEFNSDYVV
                     VNYPHTYELLPIVYGILKAGKIYIPVDNTSPLTEIEPIRKKFKDSIYISENASDLAVSK
                     ALGMEHRLLDYSENELAYIIHTSGTTGVPKGVCVTKNNLNYILEACQYIAPVSSRDCYL
                     FSTRDTFDVSITEIFGFLYNGGSVCVYSAKNKDFYKEFPDLIEKFGITHVALSPSVLGL
                     LLKLADQEDLRKIDKLKYLLVAGEEFKYELLKLVLKDLKKVNVYNVYGPTETTVYATYF
                     NVRNTPKKLQKVPIGENLPGVKTMLVKDELLIGGKGVSAGYFNNAEQTDQKFEKIDGEV
                     FYHTGDIVEKQDSLLVYRDRKDSQVQI"
     CDS_motif       complement(1503..1574)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg21_1_0002"
                     /evalue="8.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg21_1"
                     /protein_end="527"
                     /protein_start="503"
                     /score="24.6"
                     /tool="antismash"
                     /translation="ELLIGGKGVSAGYFNNAEQTDQKF"
     CDS_motif       complement(2085..2141)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg21_1_0001"
                     /evalue="6.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg21_1"
                     /protein_end="333"
                     /protein_start="314"
                     /score="24.8"
                     /tool="antismash"
                     /translation="AYIIHTSGTTGVPKGVCVT"
     CDS             complement(3076..4083)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 142.8;
                     E-value: 2.1e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_2"
                     /transl_table=11
                     /translation="LTDVSQLGGAVTTGGVMSNTYALMAAARKYPDKKIVILPNNIGHY
                     SLSYATEWLNLDVKVVYCKTKQYRLDQVELKRLLHFYGESVLFVGVYACDSMTSTCEDL
                     EGVYHVVKEVENDIWLHADACHGFALSFSDAYRSKVTYLRHYDSCTMDPHKVMWLPYTL
                     SVVLMKNADDFGTLSRTNALIMDDPLSFGKTTPFIGSKPYDSLKLWMVMKTLGVHEIGE
                     MVEARISNADLFYAILNSDINFYVGNDDILFSVIFQYVPDKDAEIEQINEVNRSIYRKM
                     LSDGEYYFHGFDIMVNGSKRFVLRYNSGNIDVTEKELRAAVNYIKKLGKEIAHE"
ORIGIN
        1 aaagctattg tttcggtcaa ctgctcatcg atatcatcat cagtagttaa gctatacgtc
       61 aaccccaggt gcaagtcgcc aattgttgtg gtgaagtcca gtttttcttg aaacttccga
      121 atattgtaga tcagattaac tttgacatta ttcaaagcaa atttcttcaa gagtttgtct
      181 cttaagtaca gcaaaatttc agcatataca tttttagtat cattgttcaa atatgtgagg
      241 ctgacaaaat taacccgatc ttcaagccgc ttaaaagttt ccgctacctt acggtcatcc
      301 tgttgctcaa acttagccat ctcttttaaa atttcttcca gatggtttct ggaatagacc
      361 tcttcaatat acgacgagta agtttggctt gagtcatata tgccaagaat gtatcgttcc
      421 aatgcatcca atgatgatga atcacaaatg ctatggtcaa tggagtaatg gagaacagac
      481 tcattttcat cttcaagcag aacaaattta tacaataatc cgccattctc aatacttgtt
      541 ttgaccaagt cactcaaagt ttttgaaata tctattctgg catcagcaac ttcatatttg
      601 gaaatattta caggcgtgtc caaaacctta aaagtattca gatcttctga caaaactgat
      661 ttaaatactt ctaccttaga aagtttatga tagatttcct catagctgat tgaatctttt
      721 ccaagataaa tctttcccgt taactgacta ttaaagccca aggaattgta tatcctagca
      781 tagaaaaaag caggatacgt atactccacc ttcctagtta taggaatatt ctttatttca
      841 ttttctctaa acagttcctt gtctgcttta gaagcaggtg atgtcgtcat gttttctata
      901 aatgaagcta tcttgtcaac cgttggggac atgtagatat taaaagcact taaatcgatg
      961 ttcagccttt tttctaattc caataccaat tcaactgagc gcagagagtc taaaccaatg
     1021 tctaaaagat tttcttctga acctactgtt tgattcatta ctgactctgc tatgtgtttc
     1081 acggtattat atatgcctat gccgcttttc ttggaatcgt tgctgctgat agatgactcc
     1141 ttcatcccgc ttaaaagctt tttccggtct accttcccac ttgaagttaa tggaaatccc
     1201 ttgacattga tatatttaga aggaatcttg taagatacca tatgcttttc cagcattgtt
     1261 ctcaaatcac taatttttgt acccgtataa aagagaatca aggaatcact ataaaaaact
     1321 acttcaatgt cccgtgtcgg atcatcaata atgttagata tatttgctct gatatctcct
     1381 aattctactc gaatgccatg aatttgaacc tgactgtctt ttctgtcgcg gtacacgagc
     1441 aaagaatctt gtttttcgac aatgtcaccc gtatggtaga atacttctcc gtcaattttt
     1501 tcaaacttct gatcagtttg ttcagcattg ttgaagtaac ctgcagatac ccctttcccg
     1561 cctatcagca attcatcttt aaccagcata gttttaaccc caggcagatt ttctccaatt
     1621 ggaacttttt gcagtttttt aggggtattc cttacattga agtacgtggc gtaaacggtt
     1681 gtttctgttg ggccatatac gttatagacg ttgacttttt tcaaatcttt taaaaccagc
     1741 tttaggagtt catatttaaa ctcttcaccg gccactaata agtacttcaa cttatcaatt
     1801 tttcgaagat cttcttgatc agccagcttt agcaaaagtc ccaatacaga aggagacaac
     1861 gcaacatggg taatgccgaa tttctcaatc aaatcaggaa attctttata aaagtccttg
     1921 tttttagcgg aatagacgca cacgcttccg ccgttatata agaagccaaa aatttcagtt
     1981 attgaaacgt cgaaggtatc tcttgtcgaa aataggtagc aatctctact acttactggc
     2041 gcaatatact ggcatgcttc caatatgtaa ttcaagttat ttttggtcac acatacccct
     2101 ttaggaactc ccgttgtgcc ggaagtatgg attatataag ccagttcatt ttctgagtaa
     2161 tcaagtagcc tgtgttccat gccaagtgct tttgaaactg cgaggtcaga agcattttcg
     2221 ctaatgtaga tactgtcttt aaattttttg cgaataggct caatttcagt aagtgggctg
     2281 gtgttgtcaa cagggatata aattttaccg gcttttaaaa ttccgtaaac tattggcaac
     2341 agttcatatg tgtgcggata attcacaaca acatagtctg aattaaattc gagcagcttg
     2401 ttggcaatat tatccgataa tttgtctaat tcttcgtaag taagattcct attttctgaa
     2461 aatacggcaa ttctttgcgg atgcttaatc acattctctt ttaacagtcg aattgcccta
     2521 ttgcttgaat ggtagcgata aaatctattg aacaagtcat caacgacttt cggtgaatat
     2581 ccccaaaatg acttgtaatt ctggttgatt tgaaatagtt ttgtaaagtc agaaaaagta
     2641 tttcctccca aactagtaaa cttcttcagt acttcttccc aagcttgatt gctatattcg
     2701 tcgtatacgc cattatcatc aaatactttc actttggttg tcaagatgtt gacaaccaat
     2761 ctatctacaa cttgaggata gtcggcttct aagtcaaaac attccggctg attcacataa
     2821 ttcttgatgg cgttgcttat tttgctctca ctcaaaagta gcttatcttc atatcttact
     2881 tcttcgtcaa ttacaatatt gttttctatt agaaattttt tatatctatg gtaaaaatcc
     2941 tcgtctacag tttgattcgt tattacacat acatcaacat cttttgcgtc tgaatgtgat
     3001 tcaatacaac tcccatagaa aattttagtg ccagtgattt tttcactatc taaatattgc
     3061 cttacaagat ccaacttatt catgagctat ctccttcccc aactttttaa tatagttcac
     3121 cgcagcacgc aattcttttt cggttacatc aatatttccg ctgttatacc gtaaaacaaa
     3181 ccttttacta ccgttaacca taatgtcaaa tccatggaaa taatactcac cgtctgaaag
     3241 catttttctg tatatactac ggttaacctc attaatttgt tcgatttcag catctttatc
     3301 aggaacgtac tgaaaaataa ccgaaaacag aatatcgtca ttcccaacat agaagtttat
     3361 atcgctattt agaatcgcgt agaataaatc agcattactg attcgcgctt caaccatttc
     3421 tccaatttca tgtacgccta gtgttttcat aaccatccag agttttaagc tatcatatgg
     3481 tttgctccca atgaatggcg ttgtttttcc gaatgataat gggtcatcca tgatcaaggc
     3541 gtttgttcta gaaagtgttc caaaatcatc tgcatttttc atcaaaacaa cactaagggt
     3601 gtatggcaac cacatgactt tatgcggatc catggtgcaa ctatcatagt gtcttaaata
     3661 cgtcactttt gacctgtatg catctgaaaa actcaaggca aacccatgac atgcgtctgc
     3721 atgtaaccaa atatcatttt caacctcttt gactacatga tatacgcctt ccaagtcttc
     3781 acatgtagat gtcattgaat cacatgcata aacacctaca aagagtacac tttctccata
     3841 aaaatgaagt aatcttttta attctacttg gtcaagccta tattgcttag ttttacaata
     3901 taccaccttg acatctagat ttaaccattc tgtcgcataa cttaaagaat aatgcccaat
     3961 gttattagga agtatcacaa tcttcttatc aggatacttt cttgcagctg ccatcaaggc
     4021 ataagtattt gacattactc cgccggtcgt aacagcccca ccgagttgac taacgtctgt
     4081 taac
//
