LOCUS       c00033_JACSUK0..       14186 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JACSUK010000008.1 Streptococcus thermophilus strain 13500
            202-13500-8, whole genome shotgun sequence.
ACCESSION   JACSUK010000008
VERSION     JACSUK010000008
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 00:46:16
            Original ID  :: JACSUK010000008.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4841
            Orig. end    :: 19027
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14186
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[9841:18791]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..13950
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14186
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14186
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             98..304
                     /locus_tag="ctg33_6"
                     /transl_table=11
                     /translation="MRERGQVWSYSEVKRESQLANYNTDGRYLSETTNFELYNFVREYK
                     TSDEIRRIWNPKKDESVIHDKDN"
     CDS             492..2249
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 389.5; E-value:
                     4.4e-118)"
                     /gene_kind="transport"
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="LFFKESIIAKLWWFFKLEKRRYIVGILALSLVSVLNLIPPMVMGR
                     VIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILATSYRLGQIMRSRLFEHF
                     TKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDASITALVTLITMFFSISWQ
                     MTLMAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQEA
                     ELQSFQETNKMTFEKNMHTMKYDSLFNPLVLLFVGSSYVLTLLVGAFMIQAGQITVGNL
                     VTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIETLLEQESDVQDPAYPLPSIENGRL
                     DFAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGPTGSGKTALVKLLLREHDVNQGAIYLN
                     GHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNVRFGNPDFSIDKVEEATKLAQVYDDI
                     KDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILDDSLSAVDAKTEHAIIDN
                     LKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHDDLLAQGGWYAKTYESQQL
                     EMEGGEAHA"
     CDS             2242..3987
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     283.2; E-value: 2.5e-86)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 314; E-value: 3.4e-95)"
                     /gene_kind="transport"
                     /locus_tag="ctg33_8"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGILSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVAIIEKTRALLSDINAKLSESIEGIRIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNV
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLL
                     DGVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVYANHFI
                     DKLPEGYDSPVSERGSSFSTGQSQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLSLGGTYHKMYSLQAG
                     TMEGE"
     CDS             4294..4404
                     /locus_tag="ctg33_9"
                     /transl_table=11
                     /translation="MTQFTTELLNFGSIISVVGKTTVEIIELFEMVPPQG"
     CDS             5001..7154
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 304.9; E-value:
                     1.9e-92)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_10"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1097.1,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.8e-45, bitscore:
                     142.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLIEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYPIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMM
                     TFARDYLLTILSQRLTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALAS
                     TILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSN
                     AMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFVDYLDNSFRLSKLSILQTSLKQGAQ
                     LILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRL
                     NEVYLIESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVG
                     VSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLE
                     NLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARAL
                     LTKSPVLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDQGR
                     VVETVSHQDLMSYPGFYYQLFRK"
     CDS             7170..8537
                     /locus_tag="ctg33_11"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEGLQK
                     QLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKTNTE
                     VNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQ
                     YATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQF
                     LQNAGQQLSSVETQITDTESKINQADVLLTNTLIQSPEDGILHLSQADKKATMAATGTE
                     LAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSA
                     TETERGNVFRVTARASISEKEAQNLRYGLESRVTSVIDQKTYFNYFKDKLLNLQDQ"
     CDS             8552..8713
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_12"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.2e-09,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQV"
     CDS             complement(8731..10071)
                     /locus_tag="ctg33_13"
                     /transl_table=11
                     /translation="MLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLAF
                     NFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLITF
                     FIFPFFNISITDYKSSLLISIPSSIAPLCLSFLFIKLFKESFTILQKQKSNSPIQHIII
                     VANFFMFGYTLLLQSLMYLENTTHSSTLELRKLCIVISLVLFFIMIVFLERNIREMIQG
                     QLDFQKNLQLENLYTYNKHIECLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEVYDS
                     VLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGME
                     TLDFIIVTSIFLDNAIEGAIQTQNHKITISFWEDHRSQLLSISNTISEEQTETKTIFER
                     GVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     CDS             complement(10071..10802)
                     /locus_tag="ctg33_14"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEEAVAHELKSFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIIRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGGTIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNKTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGR"
     CDS             11058..11234
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_15"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.9e-12,
                     bitscore: 37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGLSCDEGMLAVGGLGAVGGPWGA
                     VGGVLVGAALYCF"
     CDS             11253..11453
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_16"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2e-09, bitscore:
                     28.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNKQLERFKKLDTNALSNVSGQGYGAQCVIGTTGMTIVGAAFFG
                     IAGAGAGFAGGSTAFCYDTAK"
     CDS             11809..12039
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_17"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.9e-19,
                     bitscore: 60.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGVCSWGGFAKQGVATGVGNGLRL
                     GIKTRTWQGAVAGAAGGAIVGGVGYGATCWW"
     CDS             12547..12702
                     /locus_tag="ctg33_18"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIVMGLANLFRSLDAVHHTINLLGLTVLLYSL
                     LFKKWV"
     CDS             13044..13445
                     /locus_tag="ctg33_19"
                     /transl_table=11
                     /translation="MKLKNISSSVLRSFRTITAALAVFLISISLSLYKSKISPGTWLTV
                     GALAFVVIFVNGLLYRMLKKRPDSVNLLTIRQSFIVFPVITFLVLSVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLSYLQVKKYFKQ"
     CDS             13696..13950
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_20"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4e-15, bitscore:
                     46.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENLNTLDLETLASVEGGGCSWGGAGGATVQGAIGGAIGG
                     AFGGNVVLPVVGSVPGYLAGGVLGGAGGTVAYGATCWWS"
ORIGIN
        1 acacttaatg tgacagtagt cactgtattg acactaggag caacaatgac agcggttaaa
       61 gcagatactt atcaaaagtg gccgtgatgc cgatattatg cgagaaagag gtcaggtttg
      121 gagctattct gaggttaaaa gagagtctca attagctaac tacaacactg atggtcgcta
      181 tctcagtgag acaactaact tcgaattgta caattttgtc agagagtata agacatctga
      241 tgaaatcaga cgtatttgga accctaagaa ggacgaatca gttatccacg ataaggataa
      301 ctgattctat tgatgatggg cacaaggtct ataattttga ctcctttgct tatcaattgc
      361 cagagtctac tgattttgga aaattgactt atattggtca ctttcagtta gaagatggta
      421 caatttatcg ctattggaaa taactttcat tagacttata atcatccttt tgtagggata
      481 gggggaataa cttgtttttt aaagaatcaa tcattgcaaa actttggtgg tttttcaagt
      541 tagaaaaacg ccgttatatt gtcgggatac tggcactgag tttggtttcg gttctcaatc
      601 tgattcctcc tatggttatg ggtcgggtca ttgatgctat cacatcggga aaattaacca
      661 atcagatctt gcttttgaat ctcgtttatt tgcttttggc ggctttagga atgtactatt
      721 tgcgctatgt ttggcggatg tatatcttgg caacgtctta tcgcttggga cagattatgc
      781 gttcgcggct ttttgagcat tttaccaaga tgtcgccttc tttttaccaa aagtaccgaa
      841 ctggtgatct catggcccat gccaccaatg atatcaactc tctaacccgt ttggctggtg
      901 ggggtgtcat gtcagccgtg gatgcgtcta tcacagcctt ggtgacttta atcaccatgt
      961 tcttcagcat ttcctggcag atgaccctga tggcagtctt acctctacct ttcatggctt
     1021 ttgcgactag tcgtttggga cgtaagaccc acaaagcttt tggagaatcc caggcagctt
     1081 tttctgaact taataataag gtacaagaat cggtgtcagg tatcaaggta accaagtctt
     1141 ttggctatca ggaggctgag ctccagtcct tccaagagac caataagatg acttttgaaa
     1201 agaatatgca taccatgaag tatgacagcc tttttaatcc tttggtcttg ctctttgttg
     1261 gctcatctta tgttttgacc ctccttgtcg gggcctttat gattcaggcc ggtcagataa
     1321 cggtcggaaa tttggtaacc tttattacct atttggacat gctggtttgg cccctaatgg
     1381 ccattggctt cctctttaat atcacgcaga ggggaaatgt gtcctaccaa cgtatcgaga
     1441 ctcttttaga gcaggaatca gatgttcaag atcctgctta tcctcttcca agcattgaaa
     1501 atggtcgttt agactttgcg attgaccgct ttgcttttga ggatgaggat actttgcgag
     1561 atattcattt caccttggac aaggggcaaa cccttggttt ggttggaccg actggctcag
     1621 gaaagacggc tcttgtcaag ttgctcttgc gggagcacga tgtcaatcaa ggagccatct
     1681 atttgaatgg acatgacatc cgagactatc gcctatcaga cttgcgtagc ttgattggtt
     1741 atgttcctca agaccagttt ctctttgcca gttctatttt agacaatgtc cgctttggta
     1801 atccagattt ctccattgat aaggtggaag aagcgactaa gttagctcaa gtttatgatg
     1861 atatcaagga tatgcctgaa ggctttgaaa caatcattgg tgaaaagggt gtcagcctat
     1921 caggtggtca aaaacaacgt ctggctatga gccgggccat gattttgaat ccagaaattt
     1981 tgattttgga tgactcctta tctgcggttg atgctaagac agaacatgcc attattgata
     2041 atcttaagca tactcgcaag gacaaaacaa ctattattac cgcccaccgt ctcagtgcgg
     2101 tggtgcacgc tgacctcatc ctggtcatgc aagatggtcg tatcattgaa cgtgggcgtc
     2161 atgacgactt actagctcaa ggtggttggt atgccaagac ctatgagtct caacagttag
     2221 aaatggaagg aggagaagct catgcctaat caaaaccaat ggtctgtgtt taagcgtctc
     2281 ttgacctatc tcaagcctta caagttcttg acctttctag ctttgacctt cctcttgtcc
     2341 acaacggtta tcaagagtat cattcccttg gtggcctctt attttattga tcactatctt
     2401 catgatatga atcaggcggc aagtatgatt ctgattggct actatggtct ctacctcttg
     2461 cagacactag tccagtatct gggaaatctc ttctttgcgc gtgtgtccta tagcattgtc
     2521 agagatattc gtcgagatgc ctttgccaat atggaaaaac tgggtatgtc ttactttgac
     2581 aagaccccag caggttccat cgtttcccgc ttgaccaatg atactgagac cattagcgag
     2641 atgttctcag gaattctgtc tagttttatt tcggctatct ttatctttgt taccaccctt
     2701 tacaccatga tgatcttgga cattcgtctg accgggctta ttgtcctctt tcttcctctg
     2761 attgtccttt tggttaacct ttatcgcaaa aaatcagtgg ccatcattga aaagaccaga
     2821 gccttgcttt cagatataaa tgccaaactg tcagagagta tcgaagggat tcgcatcatt
     2881 caggccttta accaggagaa gcgtcttaaa aaagagtttg atgccattaa tgaggaacac
     2941 ctgatttatg ccagccgttc tatatcactg gattctctct ttctacgccc agccatgagt
     3001 ctactgaagc tcctggctta tgctgttctc atggcctatt ttggctaccg aggtatctat
     3061 ctgggtatca cagcaggtac catgtatgcc tttatccagt atattaatcg cctctttgat
     3121 cccttgattg aagtgacaca aaacttctcg actctacaaa cctctatggt ctcagcaggt
     3181 cgggtctttg ccttgattga cgagcgtacc tatgagcctg aacagagaga cacagctgcc
     3241 aaggttactg agggaaatgt tcgctttgag aatgtctcct tctcctatga tggcaagcac
     3301 cagattttgg ataatatttc cttctctgtc aataaaggtg aaaccatcgc ctttgtggga
     3361 tctacaggct ctggaaaatc ctctattatc aacgtgctca tgcgattcta tgagttccaa
     3421 tcaggacgag ttctcctaga cggtgtggat attcgtgatt atagtcaggc agagctgcgc
     3481 aagaatattg gtcttgtcct tcaggacccc ttcctctatc atggcacaat caaatccaat
     3541 attgccatgt atcaagattt aactgatgaa gagattaaag ctgctgctga gtttgtctat
     3601 gccaatcact ttattgataa acttcctgaa ggctatgatt ccccagtttc cgaacgtggt
     3661 tcaagtttct caaccggtca aagccagctt ctagcctttg ctagaaccgt tgctagccag
     3721 cctaaaatct tgattttgga tgaagcgaca gccaatattg attcggagac agaggctatt
     3781 gttcaaaact ctcttgcaaa aatgcgtcaa ggccgtacaa ccattgccat tgctcaccgc
     3841 ctatcaacaa tccaagatgc taactgcatc tatgtcttag acaagggccg catcattgaa
     3901 cacggtagcc acgaagagct cctatccctc ggcggcacct atcacaagat gtacagccta
     3961 caagcaggca ccatggaagg agagtaagct aatctagacc atagcttcta tattcgaaaa
     4021 gatttcttaa aaatcaaaat cgagtagtga catttatgtc actacttttt tgttggctac
     4081 caccctataa taaaatcata gcttgagaga aaaagctaaa aataatttag gaggttgtta
     4141 gaatgacaag gcaaacaaat aatacatttg aaacactcga tctcgaggca cttgcaaatg
     4201 ttgaggtagt gtaaaataag ttgtgtaaac acaaaaagga ataaatccgt tatagtagag
     4261 ttgcaaaaca ttactagaaa gagatttatt cctatgactc agtttaccac agaactactt
     4321 aacttcggct ctataatttc tgtagtggga aaaaccactg tagagattat agagcttttt
     4381 gagatggtgc cacctcaagg ttgagtaaat caaaagatag aaggcacaat tactcaaggt
     4441 ggaaataagg tgggcattaa ggaagggaac ccctctagtg acgctaaaaa tagcattgac
     4501 agtgataaca aatacactta caaagctaag gaaaattaaa ccgataattg agtaatcgaa
     4561 tctcaagagg ctgatttagc cttttttgat aggatttttt gagatatgga ttgacgtttt
     4621 tcataatgtt atcccttttc ggaataaaaa taatcaaatt atgacatcat acgatagaga
     4681 taggctccga ggctatcagc agtcatggtt tcctttgaaa ataccagggc tggcacagta
     4741 ataatggtta gatcaaatac ttatgcttgt aggactattt tagaatgttt ccttctaata
     4801 actattgtat aactttgaaa tcgatttcaa tgaacttgtc ctaaatgacc ccaaatacgg
     4861 cttaaatggt aatagtggag atgactttaa gatttttctt accgtttggg acgtatggca
     4921 actttttggg acgctggctc tttttatcct gaaaatatga catactaatc atatgataat
     4981 ttgtgatgaa agggtttggt atgtttcgtt ttcgtaggac ttttgtccct caaatagaca
     5041 tgagggattg tggagttgct gccttggcat cagtggccaa gtactatggt tcagattatt
     5101 cattagcaca tctgcgtgag ttggcgaaga ccaataaaga agggacaact gccttaggtc
     5161 ttatagaggc tgctaaaaaa attggctttg aaacgagagc tataaaggct gaaatgtcgc
     5221 tctttgagat ggaagatgtt ccttatcctt ttattgctca tgttaataaa gatgggaagc
     5281 ttcaacatta ttatgttatt tataaaagca ccaaggatta tccgataatt ggagaccctg
     5341 atccaagtgt aaaagtaact aaaatgacta aagagcgttt tgagaaagag tggacaggtg
     5401 ttactctttt tatgggaccg gaacccagtt ataaaccaca taaggataag aaaaatggac
     5461 tctgggactt tctccctttg atctttaaac aaaggtcctt gatagctaat attgtctttg
     5521 ccagtctctt ggttacttta ataaatattt taggttccta ttatttacaa ggtattctag
     5581 acgaatatgt ccctaatcaa atgaagtcta ccttaggaat tatctcaatt ggattagttg
     5641 tgacctatgt tttacaacaa atgatgactt ttgcaagaga ttatctctta accatactga
     5701 gtcagcgatt gaccattgac gttatcttgt cctacatacg acatatcttt gaactcccaa
     5761 tgtctttttt tgccacaaga cgtacagggg aggttatctc acgttttagt gatgctaact
     5821 ctattatcga tgctctggct tcgacgatat tatcactttt ccttgatttc tctattgtga
     5881 ttatcgtagg aggcgtgtta ttgatacaaa atagcaatct cttcaagcta gttctttgtt
     5941 cggttccaat ttataccctt atcgtctttg cctttatgaa accttttgag cgaatgaatc
     6001 atgacgtcat gcagagtaat gctatggtta attcagccat cattgaggac attaatggga
     6061 ttgaaaccat aaagtcacta accagcgaag aagtatgcta tcaaaagatt gatggtgagt
     6121 ttgttgacta tctagacaat tcttttcgcc tttctaagtt atctatacta caaacatcat
     6181 tgaaacaagg tgctcaactt attttaaatg tacttatcct ctggacaggt gctcagttgg
     6241 tgatgggaaa taccatttcg ataggacaat tgattacttt taatatgttg ctttcttact
     6301 tcacgaatcc tttggaaaat atcattaacc tgcaaaccaa gttacagtct gctaaggtag
     6361 ctaatactag gctcaatgag gtctatctga ttgaatcaga gtttggacaa agtgatgata
     6421 cctatcaaga aggcattgcg gatggagata tcactgttac ggatttatct tataaatatg
     6481 gttttggtcg tgatactttg actgatgtca gtttgacgat tagacaagga gaaaaaatca
     6541 gttttgttgg tgtcagtgga tctggtaaga ctactctagc taaaatgttg gtcaattttt
     6601 atcaaccata taaggggcac atagatttta atggtcaaaa tattagtcgc atagacaaga
     6661 aaactcttcg tcaacatatt aactatctcc ctcagcaatc ctatatattt agtggtagtg
     6721 ttttagaaaa tcttacttta ggtgcagcac ggggtattac gcaagctgat attttgaaag
     6781 cttgtgaaat agcagaaatt cgtcaagata ttgaaaacat gcctatgggg tttcagacag
     6841 agctgtctga tggagcaggt ctgtctggag ggcaaaagca acgtatcgct ttggcgcgtg
     6901 cactactaac gaaatctcct gtactaatct tagatgaagc aactagcgga ttggatgttt
     6961 tgacagaaaa gcaggttatt gataacctcc tagcactaaa agataaaacg atcatctttg
     7021 tagcacacag gcttagtatc gctgagcgga ccgaccgtat cgtagtcatt gatcagggac
     7081 gcgtagtgga gacagtttct catcaagacc taatgtctta tccaggtttc tattatcaat
     7141 tatttagaaa gtgaggaaaa ggaaacacga tgaatccaca gttgtttaaa agcacagagt
     7201 tttaccatcg tcgctaccac aatatgtcta ctgttttgat tactcccttg attttgttag
     7261 ttattttcct ttttcttttc gctttttttg ctaagaagga agttacagtc acgtctagag
     7321 gaagtataga gccaaccaag gttatcgcag taatccaatc aaccagtgac aataccatca
     7381 tagataatca actggttgct aataaggttg ttaaaaaagg ggacacctta gttcagtatt
     7441 cagagaccat ggaggcatcg caaaaagagg ggcttcaaaa gcaactagaa cttttaaaaa
     7501 gacaggaatc aggtttgaag accttgcaat ctagcctaac gcagggaacc aatcttttcc
     7561 aagaacagga agacgagttt ggttatcaga gtacttttaa cacctaccta agtcaggcac
     7621 aggatattga cttgggtgtg gctaaaacaa atacagaggt taataaccaa gcagcaattg
     7681 cgagtaatac cggttctgct attgataacc agattagtca attgcagact caggtctcag
     7741 agtatgaggc gctctctcaa gctattacca atcatgaaac gactttacct gaaggcaatc
     7801 ctcatcaggc aaccttaaat gcctataaca gtcagtatgc tacgacaccg gatgccagtg
     7861 taacagacca atacctatct caagttaata ccaatatttc gagcttgaat gcttccatag
     7921 gtaatctaga aatccaaaag gctgggacag gcacagttgt aacttatgac aatagtgata
     7981 gcactaaaaa agaagctcta aaaaatcaat tcttgcaaaa tgcaggacag caattgagct
     8041 cagtggaaac acaaattacc gataccgaga gtaaaatcaa tcaggcagat gtccttctga
     8101 ctaataccct catccagtca ccagaagatg gaatcttaca cttgagtcaa gctgataaaa
     8161 aagcaaccat ggctgcgaca ggaactgagt tggcccagct ttatcccgat atgactcaaa
     8221 cccaggaagt tgccattact tattatgtga attcggatta tgtgccaaaa ctgcaaaaag
     8281 gccagtcagt tcgactgacc ttggataagg ttggtaatca cggtaccaca attattggaa
     8341 aacttgagag tattgataat tctgccacgg aaacagaaag ggggaatgtg tttagagtaa
     8401 ctgctagggc aagtatttca gaaaaagaag cccaaaatct acgttacggt ctagaaagtc
     8461 gtgtgacaag cgttattgac caaaagacct acttcaatta ctttaaagac aagttactaa
     8521 acttgcaaga ccaataggag gagaattacc gatggctaac aatacgatta ataactttga
     8581 aacacttgat aaccacgctc ttgaacaagt cgtaggtgga agtgggtgga tggattatat
     8641 aaatggtttc ctaaaaggat tcggagggca aagaacgctt ccaacaaaag actataacat
     8701 tcctcaagtt taggtataga aaaaaggctg ttaggccttt ttagttattg ttaattgttg
     8761 tgtgaatgag aaattgttac tctgtgtttc taagtttaca ttgatatagt tatctaagat
     8821 ttctgtgaca ttagcaaggc caatgcctcg ctctcgtccc ttgttggaga cacctctttc
     8881 aaatatggtt ttagtttctg tttgttcttc acttatggta ttgctaatag ataatagctg
     8941 tgaacgatga tcttcccaaa agctaatagt aattttatgg ttttgagttt gaatggcacc
     9001 ttcaatagcg ttatctaaaa aaatagaagt gacgataatg aagtccagag tctccatccc
     9061 aatcaagtgg atgggttctg ggatgctaat ctgagcttca ataccttctt cttctgcttg
     9121 taaaactttt gcggacagaa ggcttttcaa agtattatcc tgaatattaa cgagtctagc
     9181 taagtcaaag tttcttgtat ttaatcgttt atcggattct tgaagcacac tatcatagac
     9241 ttctttgaca atatccatat cgtctttatc tatccccaat cgtaatgtga ctaagagatt
     9301 actataatcg tgtctaaaac tacgaacaga attgtagaga cattcaatat gtttattgta
     9361 ggtgtagaga ttctctagct ggagattttt ctggaagtcc aattgtcctt gaatcatttc
     9421 acgaatgttt ctttctaaaa agacaatcat aatgaagaag aggacaagtg aaataacaat
     9481 acagagtttt cgaagctcca aagttgaaga gtgagtagtg ttttcaagat acatgaggga
     9541 ctgtaacagt agggtgtacc caaacataaa aaagttagca actataataa tatgttgaat
     9601 cggagaattt gatttctgct tttgaagtat ggtaaaactc tccttgaata atttaataaa
     9661 gagaaatgat agacaaagag gtgcgataga tgaagggatg gatattaata gagagctttt
     9721 ataatcggtg atactaatat taaaaaaagg aaagataaaa aaagtaatca gtcttaaact
     9781 aaggttgttg aggatatcag ggaagagacc attgaaaatc tttattttta atggtttttt
     9841 agtcttagtg gataaaagga aggagagcag aagatagtag atatcctcac cccagaattt
     9901 aatgataaac caagaagagt ggttataaat aaaattaaag gctaaattaa aaataaggag
     9961 taggaaaaaa tacctcagac gaatcttctg tcccattaaa taaaggaaaa gaataatttc
    10021 taggcctgca cttaaaaggg tgagaaaaag tagccataac gttgttaaca tcatctgcct
    10081 ctttcctcaa caatctgtgc aatctttcct atcttcatac gggatactgg tagaacttga
    10141 ccattaatta aggtagcttc ataattggtc ttgttgacag agatgatcat atctgtattg
    10201 acgatatagg accgatggca tgggtagagc tttttgtgta tctttttaaa gtctgccaga
    10261 tttgctcgga tatccatgag ggtatggata gtctggaggt gaacatggtg tttgatatct
    10321 gatgtggata ggtatagaat ttgatccata ggaaggttta ttaattgaga ctctgttttg
    10381 tagagaaaaa actcatccgt ggtagttgcg ttaataggga agacttgagc aatggttccc
    10441 cctatttctt ttctaaagct agcttcatct aaggttttat tgatgtattt ataggctgta
    10501 acgccaaaag cttgaggcat gaactctata tgtgtagtga caaaggcaat gatagcataa
    10561 gggttatttt gacgtatgat tttagcgata tcaagtccct tcttatcttc acctttaatt
    10621 tcaatatcaa gaaagaaaat ctgatcgctt gtattagaag tgatagctga taacaactgg
    10681 tcaggtttgt caaaagactg gacacaagat agatcttttc cgaaggattt aagttcatgt
    10741 gccacagcct cttccaagcg acccatctga atagaattat cttctaatag gtaaatcttc
    10801 aaggtctagt cctctctttt atgacgaata ctgtttattg aaaaattgta acataaagaa
    10861 aacggttttt caatttttta tgagtataaa atgagatttt tttttttttc tgaattttag
    10921 aaataatata cattaggaat taccattcgg gacatatagc cactttttgg gacgctagct
    10981 ctgatagaga cacttgaatg ctatactaaa gatgtgattg agagatcaca cgataaaaat
    11041 tttaggaggt agttgccatg gcaactcaaa caattgaaaa ctttaacacc ctcgacctcg
    11101 aaacacttgc tagtgttgag ggtgggttgt cctgtgatga ggggatgctg gcagtaggag
    11161 gacttggtgc agtaggtggc ccgtggggag ctgtcggtgg ggtgttagta ggtgcagcct
    11221 tatactgttt ctaatttgta tgggaggaat ttatgaataa taaacaactt gaaagattta
    11281 aaaaactgga tacaaatgca ttgtctaatg taagtggtca aggctatggt gctcaatgtg
    11341 ttattggtac taccggaatg acgattgtcg gtgcagcttt ctttggcatc gcaggtgcag
    11401 gagctggatt tgcaggcggt agcacagcat tttgttatga tacagctaaa taatcttcat
    11461 ttgagatagg tgatacaaat gaagaaatac ctaatcattt tttcgactat tgcgatgata
    11521 tatttatata gcaaagtact attgtcatca ggaaatatct atcaactttt gttagcatca
    11581 ataggattct ttttcttttt atttggagtc tataggcagt atagaaagaa ttagttaaag
    11641 ctttttcaat aagacatgga ctgaatcaaa aatgatattc agtctttttt ttactactcg
    11701 ggacatatag ccactttttg ggacgctagc tctgatagag acacttgtat gctatactaa
    11761 agatgtgatt gagagatcac acgataaaaa ttttaggagg tagttgccat ggcaactcaa
    11821 acaattgaaa actttaacac ccttgacctc gaaacacttg ctagtgttga aggtggtgta
    11881 tgtagctggg gaggttttgc taaacaagga gtagctacag gagttggtaa tggtttacga
    11941 ctaggtatca aaacacgtac ttggcaaggt gctgtcgcag gagcagctgg aggtgctatc
    12001 gtaggtggtg ttggttatgg agcaacatgc tggtggtgat ggattatgtt tgatttgaaa
    12061 agttatattt tagggatggt ttccatggct gttatgagtt ttttagataa gccaattatg
    12121 tcatttcttg aaaaacacaa ggctaccaat tccgttaaga agaaatcttc cgttaagaag
    12181 aaatcctaac tgaaatgtct tgtcaattgc tggtctgtga atagcatgtg aattatgatt
    12241 gaaaatttcg atataagaga agagttattt gtaatcatga ccaaaaaacg cctagtgtct
    12301 ctaatgatgt ctatgggctt cgtccttgtt gccttacata actttggaga aaaactgaat
    12361 tttggacttc aatgcctaaa tcttatcggg ttatgtttat ttctctttct tatgtgtacg
    12421 gttatcaagg atataaggtc agacaagtag tgacatttat gtcactactt ttttatcggc
    12481 ttccaatcta taataaaatt catagattat gcacagacta gctaaaaaca ctttaaggag
    12541 aaaagtatgt ttaaaaactc aaaaccgtat ttactggcta ccattctcat cgtaatgggc
    12601 ctcgctaatc tatttagaag cttggatgca gttcaccata ccattaactt gctagggcta
    12661 acggtgcttc tttatagctt actttttaaa aagtgggtat agtttcaaaa gtaacctttg
    12721 gtcactttga acgtaagatg cttgcaaatg cttatttttg atgttcccga agtaaaatta
    12781 ttcttgctaa tgatagcgga gattatatta tatttgattg catatctttg taatagagaa
    12841 aacaaagata tgtatattcg cctatttaaa gtatcagtac taatgacact actgtattac
    12901 atctccagta gaatttaatc gctaagggct tacttgaaat cttacagctg tataataaaa
    12961 tacagagagg aatagagtta aatgtaatag cttattaggt ttgcaagact gactgaggtt
    13021 attcatagtt taggtgtttt atcatgaagt taaagaatat tagttcgagt gtattgcgat
    13081 cttttagaac catcactgct gcgttggcag ttttccttat aagtatcagc ctttctctct
    13141 acaaaagcaa gatctcgcca ggaacttggc taacagtcgg agcactagct ttcgtagtca
    13201 tttttgttaa tggactgctc taccgtatgc ttaagaagcg tccagattca gtaaatctgt
    13261 taacaatacg gcagtccttc attgtctttc ctgtcatcac atttctagtg cttagtgtag
    13321 agttttacac attactaaca ttcagtgata ccacagaccg tatagtacta gccgtattaa
    13381 tgcttttgtt aatcctctgt gattttctat cttaccttca agtcaaaaaa tattttaaac
    13441 aataaacgca tttgcttgat tattctgtaa gcaatctata agatatttgc ataaaagtgt
    13501 tataataaga aagtgattaa gtaaatatgt gaaaattaga ggaagatttc caatgattga
    13561 aggatgttct ttaggaatta ccattcggga catatagcca ctttttggga cgctagctct
    13621 gatagagaca cttgaatgct atactaaaga tgtgattgag agatcacacg ataaaaattt
    13681 tagggggtag ttgccatggc aactcaaaca attgaaaacc ttaacaccct tgacctcgaa
    13741 acacttgcta gtgttgaagg tggtggatgt agctggggag gcgcaggtgg agcgactgtt
    13801 caaggagcta tcggaggagc tatcggagga gcgtttggag gtaatgtagt tttaccagtt
    13861 gtaggctcag ttcctggtta tctagctggt ggtgttctag gtggtgcagg tggtactgtt
    13921 gcctatggag caacctgctg gtggagctaa tctatggtat attttattat aggttttgtt
    13981 gttgctttgt taggtaatat ctttttcaaa aaggtcaata aaaataaaca taaaaaataa
    14041 tcttgaacat atattgaata gctccctgtc aagtggacaa tgaaataata aaatattagg
    14101 cgacggcctt gttcctcatt tcaagagggg caaggccgtt attgcgctct tgaaaacgtt
    14161 gatgattgta aaaatagatg taggca
//
