LOCUS       c00005_JACSUN0..       17070 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JACSUN010000013.1 Streptococcus thermophilus strain 13497
            202-13497-13, whole genome shotgun sequence.
ACCESSION   JACSUN010000013
VERSION     JACSUN010000013
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 00:51:37
            Original ID  :: JACSUN010000013.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 47036
            Orig. end    :: 64106
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17070
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[57036:59461]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12425
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17070
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17070
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             2579..3787
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.5; E-value: 8.1e-77)"
                     /gene_kind="other"
                     /locus_tag="ctg5_44"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMEKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
     CDS             3784..6963
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 497.2; E-value: 1.7e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg5_45"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDHFQKSLEERLRQSNKDMEKRQAQLDGHFASQVWSE
                     EELSVLEQTPASEKLTRLEEFLSQRQENVTKQKSILKAAHEDLAQLQKSLQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELTVQSKDFLQKEEELETWKENIIYAQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLDSLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLIIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVAKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIHKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             7363..7875
                     /locus_tag="ctg5_46"
                     /transl_table=11
                     /translation="LAAAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQ
                     PYMTESAYSQELTSQNDAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSD
                     LKNANQSKTNQTETRTVNLNYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPS
                     LPNTTTK"
     CDS             7885..8016
                     /locus_tag="ctg5_47"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             8028..8186
                     /locus_tag="ctg5_48"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             8365..8931
                     /locus_tag="ctg5_49"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             8925..9761
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.7; E-value: 3.2e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg5_50"
                     /transl_table=11
                     /translation="LVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             10001..10861
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_51"
                     /sec_met_domain="TIGR01716 (E-value: 4.9e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             10944..11036
                     /locus_tag="ctg5_52"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             11106..12425
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_53"
                     /sec_met_domain="PF04055 (E-value: 4.8e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.7e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-13, bitscore:
                     43.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.7e-07, bitscore: 22.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 9.8e-25, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTNMEIMSNGDILPCIAFLGVNQTKQNVFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             12422..13513
                     /locus_tag="ctg5_54"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             13607..14209
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_55"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.4e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALELDGTLLGSDLACFYEQKGGGVVV"
     CDS             14206..14295
                     /locus_tag="ctg5_56"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             14525..15436
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_57"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(15536..15835)
                     /locus_tag="ctg5_58"
                     /transl_table=11
                     /translation="LCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(15995..16264)
                     /locus_tag="ctg5_59"
                     /transl_table=11
                     /translation="VQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             complement(16434..16535)
                     /locus_tag="ctg5_60"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             complement(16764..16877)
                     /locus_tag="ctg5_61"
                     /transl_table=11
                     /translation="MPTKIWLKPEQLDLYIKHLERFRDLYSKLDCSGIVNL"
ORIGIN
        1 ggtcttgtgg taatgaatca tatgctggta aagatattgc tgacatggct gattacttcc
       61 gtagtgttga caatactcgt ccagttcact atgaaggtgt tgcatggtgt cgtgagtttg
      121 attacattac agacatcgaa agtcgtatgt atgcgaaacc agctgatatc gaagaatacc
      181 tcacaactgg taaactagtt gatctttcaa gcgttagtga taaacacttt gcttcaggta
      241 acctaactaa caaacctcaa aaaccttata tttcatgtga atacatgcac acaatgggta
      301 actctggtgg tggattgcaa ctctacactg acttagagaa atatccagaa taccaaggtg
      361 gatttatttg ggacttcatt gaccaagcta tttacaaaac acttccaaat ggtagcgaat
      421 tcctatcata tggtggtgac tggcatgata gaccttctga ctacgaattt tgtggaaatg
      481 gtatcgtctt tgcagatcgt accctaactc caaaacttca aacagttaaa catctttact
      541 ctaatattaa gattgctgtt gatgaaaaat cagtaactat caagaatgat aatctcttcg
      601 aagatctttc tgcttatact ttcctagcta gagtttacga agatggtaga aaagttagtg
      661 aaagtgaata tcactttgat gttaaaccag gcgaagaagc aacattccca gttaactttg
      721 tagtcgaggc ttcaaattct gaacaaattt acgaagttgc ttgtgttctg agggaagcaa
      781 ctgaatgggc tcctaaaggt catgaaattg ttcgtggtca atatgttgtt gaaaagatta
      841 gcactgaaac accagttaaa gcacctttga atgttgttga aggcgacttc aacatcggta
      901 ttcaaggaca aaacttctca atcttgcttt cacgtgcaca aaatacttta gtatctgcta
      961 agtataatgg tgttgaattc attgagaaag gtcctaaact tagcttcact cgtgcttaca
     1021 ctgacaacga tcgtggtgct ggatatccat tcgaaatggc aggctggaag gttgctggaa
     1081 actatagtaa agttacagat actcaaattc aaatcgaaga cgactctgtt aaagtgactt
     1141 atgttcatga attgccaggc ttgtctgatg tcgaagttaa ggtaacttat caagttgatt
     1201 acaagggtcg aatctttgtt actgcaaact atgatggtaa agcaggtttg ccaaacttcc
     1261 ctgaatttgg tctagaattt gctatcggtt cacaatttac aaaccttagc tattatggat
     1321 acggtgcaga agaaagctac cgtgataaac ttcctggtgc ctatcttggt cgatatgaaa
     1381 catctgttga aaagacattt gctccatatc taatgccaca agaatctggt aatcactatg
     1441 gtactcgtga attcacagta tctgatgata accataatgg tcttaaattc accgcactta
     1501 ataaagcatt cgaattcagt gctttgcgta acagtactga acaaattgaa aatgctcgtc
     1561 accaatatga gttgcaagaa tctgatgcta catggattaa agttcttgct gctcaaatgg
     1621 gtgtaggtgg tgacgacaca tggggtgctc cagttcatga cgaattcttg cttagctcag
     1681 cagatagcta tcaattaagc ttcatgattg aaccactaaa ttaggtagtt attaagaatc
     1741 tagttgtaca ttatttgata attataaaag agaagctttg gaggcttctc ttttcatgtt
     1801 ttaaaggaga ttaaatcatt agtgtgttag tatcttccaa aaatctacaa gcggtactga
     1861 ttagcactcc aacacattat aaatatattt caagtgattt aagataggaa ttagctatta
     1921 ccggtgtttc tctaaaagaa ataaaaatca taccattcgt tcagatggaa taatgcatgt
     1981 gacttataaa aaatctcaag tagggaaata gtaaatacta catgcctagt tccaagtcag
     2041 ctaacaagct acggataaaa aaagcctaga ataaagtaaa aagtcaggag cccttagggt
     2101 tcggattatt tttaggtttt catagtgaaa aatttaaaaa ggatcggtac tgacaataac
     2161 gaaaagtgag taaatattat tgcctaaaat acaagatgtg cactagtacc aacctatatg
     2221 ataatgctta gaatctataa aagtcaatta aaagaataga taatattgat tttcttggtt
     2281 agaggtattt aaattactta accaattgag gcagggtaat ctagactata ttgattacta
     2341 caacaacaaa tgcattaagg taaaactaaa aggactcaat cctgtgcaat acagagctaa
     2401 atcctttgct tacataaatt gtctaacttt ttggggtcag tacaggatag cttgggagag
     2461 attttttgat ctttacagct aaaaaacggg aaaactatca aagcctgtga aacttttaag
     2521 cagtatttag cttgataagg tacaatagaa gtaagacaaa atgaatgagg aggttgtcat
     2581 gaagttttta catacgtcag attggcatgt aggacgaacc ctcaatggct ggtctttgtt
     2641 ggaggagcag gagtgggctt ttcaacaaat tgtggatttg gctattagcg aaaaagtgga
     2701 tggggttatc atttctgggg acctctatga ccgtgcggtg ccccctgtgg atgcgattaa
     2761 gctttttaat aagaccttgg cccgcttggt actggaggag cagattcctg tctatgcgat
     2821 tagtggtaat cacgatgggg ctgaacgttt acattttggg cgtgacttct ttcaacatca
     2881 gggccttcat ttaagtacac gtttggagga ggcttttgag cccattgagt tggagaattg
     2941 ccagattttt ctgctgcctt ttatcgatcc tattgatgct cgtatttact ataaggatga
     3001 tgagggaaag gaaattcagg ggattggtga tgccttgacc tacattcttg aggatatgga
     3061 aaaagctttt gatcctgaca aagctcatgt cttggtgacg cattttgcgg tttctaagaa
     3121 ggatgatagc gatggtcagg gtcttcgaga attgatgttg tctgaaacca gtaatacggt
     3181 aggtggtctt accaatgtga ccagtgacct tttcaagtct ttcgattatg ttgccttagg
     3241 gcatatccat acgcgttttg ctagtcctac caagcgcgtg caatattcag gcagtccagt
     3301 cgcctttaat gtcaaagaag ccaagcgtaa ggaagaaaag ggtgtctata ttcttgaatt
     3361 ggatgcgtct ggtgatatgt ctcagacctt ccatactcta gaggttaaac ggccgattgt
     3421 ggctttacag gaatcttttg aaaccttgat gtcacctgaa ttttataaga atcaaccttg
     3481 tcaaaaagcc tggttcgcct ttgatattca actgtctagt cgtaaggaat tagagggtat
     3541 caatgtgcgt gcccgactgg aagagattta tgggacagac attgtagaaa ttactttcag
     3601 tcgtctgggt gatgttaggg aagaaaactt gaccgttgat cagcacttaa aagatttgga
     3661 aatgcagtcg ccccaggaaa tcgtatttga tttttaccag acagtaactg ggggcgatgt
     3721 cttatctgag agacagactg cccttgtgga aagtgttttt gaggagattg agaggagtcg
     3781 acaatgagac cagtccagtt agaattgacc aattttggac catatcgtaa ggaagttatt
     3841 aatttcactc agtttgacca tgctcccctc tttttgattg gaggggatac aggggctggt
     3901 aagagtactc tctttgatgc catgacggta gccttgtttg ctacgaccag tggtgatcgt
     3961 aatgttgagg agatgcggtc aactttcgct ggtccagagg atgatttgac caaggtgact
     4021 ttctatttcc aacaaggcaa tcacctttat cgcattgacc gagttctcca gcaagagagg
     4081 gccaagcagg gtgggggcac taccatgcaa aaggcgacgg cttctctagt cattgtggat
     4141 aagattggtg gtcaggaaat tgaaaagctt ggggataaga tcaaggaagt gagtgaccag
     4201 attgagcaga ttttggggct caatgctgag cagttcaaac agattattct ccttccacaa
     4261 aatgatttca gccgtttctt gaaagaagat tctaagacca agactcaaat tttaaagaaa
     4321 atctttggaa cgggtatttt tgaccatttt caaaagagct tggaagagcg tcttcgtcag
     4381 agtaataagg atatggaaaa gcgtcaggct cagctagatg gtcattttgc cagtcaggtt
     4441 tggtctgagg aagaattatc cgtcttggag caaacgccag cctctgaaaa attgacacgt
     4501 cttgaagagt ttttgtctca gcgtcaagaa aatgttacga agcaaaaaag tatcttgaag
     4561 gctgcccacg aggatttggc acaactgcag aagagcttgc aaactgccca agatttggca
     4621 aagatttttc aagaattgga gcaagccaag gaacgttacc gtctggaaat tgaggagggg
     4681 gctcaaggac aggcagaggc aaaagtgcat ctggaggaat tacagtttgc tcaaggtctg
     4741 caggaaacca ttcggacctt gaagcagtat cggaaacagt tgatgcaatt agagcaggac
     4801 cttgaaattg ctcaagaagc cttaagtgaa aagcaacagg cgtttgagga tgttaaggct
     4861 aaaaaagagg aactcacagt tcaatctaag gattttcttc aaaaagaaga ggagcttgaa
     4921 acttggaaag agaatattat ctatgcccag agtcttgccc aagaacagga gaaaatcaaa
     4981 cgttcaacga ctaactacaa gcagttggaa gagacctatc agcaggctag aaaagaggtt
     5041 gagatgctta acaagtcctt gtctgacttg gaggctaatc gtcttagttt agatagttta
     5101 catgaggccg aaaaactctt ccagattgtg ggctacagtg tggagaatca acttgctcag
     5161 gacctgaaag aaatagagaa cttgaatcag gagttgacaa agaccgaaaa acgtcatcaa
     5221 acgttatctt ttgatattga tcaagctcaa gaaattctca aagaattgga agaggagtta
     5281 agaaggactt tggtttcacg ccgtcaactc attattgtcc aactgcaggc agagttagag
     5341 gaggggcatc cttgtatggt ttgtggtgct ctggaacacc ctaatgttgg tggagcacag
     5401 gctgatgaag tggccttgaa aaatctcatg gatcaggtgg agaagcttca agctcaaaaa
     5461 gaaaagcaag tcgctacttt atcaaatcgt caggctacct tgagtgaagt tgcatctaaa
     5521 cgtcaggatt tgcttgacca agtggctaaa gtcaaggcaa ctcttgaaaa gcactatcaa
     5581 gaattagaag agcacgttaa gggacggttt gattttgatt tttcgataga ctatgaaact
     5641 gaccgtgggc aagccctact cctgaaggtt gagcagtatt atcaagagtt acaaaaacgt
     5701 tatgataagg aagagacaga ttatatccga tatcaagatg agctaggtaa ggctcaaaaa
     5761 aaagcgacag atttggctaa aacctatcaa gaggccaagg cagtgcttga ccaagctcaa
     5821 gaacgcctag aggacctgca ggaagctcat ccagaacttg agtctgttga ggtatatcaa
     5881 gaacggattt cccttgctca tcaggagctg aacctctaca ataagcaagt caaggaaaat
     5941 agcgaagcct acaaccaact tcatgccgac attaaaggaa taaaggggca gattgagagt
     6001 ataactaagt ctaaagataa ggtaaatcaa gatgttaagc gattatctgc tgaattagag
     6061 caaagtctca aggctgaagg agccctcgct aatgacttag agcaggtcga actctggctt
     6121 attgaggtaa ataatcaagc tattcctatg cttcaggcca aattaacgac ctatgcaacg
     6181 ctcaaacaag aattacaggc gcagattcat aaggggcaag agcttctcca aaatcaagaa
     6241 caaccagatc tcgatagtct agcgcaagca gtacagaatt gtcaggaaat ctatgatagg
     6301 cagctcgctc agttttctgt catggaaaag ggacttaagg atgcgacggc tacctaccaa
     6361 gcggctaaaa cccttcaaga cagtaaccaa gaggccttta aggcccacca agaactcagt
     6421 gatttggtta aggtggttaa gggagaaaat actgctctaa ctggtcgtct taatcttgag
     6481 gtctacgtta tccgtcagta tttccaacaa atcttggact atgccaatgc taactacatc
     6541 ggactattaa cggataaccg ctattccttt gttctaagtg aggaaggacg cagggcgcgt
     6601 gatcacttcg gtttggatat caacgtctat gaccagctga caggtagtga acgctccgtt
     6661 aaatccttgt ctggtggtga aacctttatc gctgcactgg ccattgccct atccctctca
     6721 gaagttgtcc aaaataccag caagggtgcc gttgttgaag ctctcttcat cgatgaaggg
     6781 tttggctcac tggataagga agccctgacc aaggccattt ctgttctgga acaaatcggt
     6841 gaaaaccgca tggtcggtgt catcagccac gtagacgata tgaaagaagg tattgctcag
     6901 caactagtta tcatcaagtc gcacgatggc agtagccgta ttaaaattgt ggataagggg
     6961 taggaggaat cagtttatat aatactctat atcagataat cgcagttgta gccatgtcaa
     7021 atttgttcta atcagcatag aaaaaaggta gttgcatcaa caactacctt atgtagaatt
     7081 gttaaaaagc tgatggtttg tataacatat ttaattcgtc ctactcgtaa aaaagtgcgg
     7141 acggattttt ttgtcatcat atttgacaat gttatagcaa aaactaatca aagtaatatg
     7201 aggctaccta atgtctccct aattcgttga acttttagct aggtgaagta attatcaatt
     7261 tcctcctcat tttttagtat atccacctca tcaacaccac aacttactgc taattctatt
     7321 ggtcaacatt ctactgccaa acaaagtcga aaagaaatcg aattggctgc agctaaactt
     7381 gtagaggaca aacaagcaga agataaagca agtattttat catcagatac tgtaaaagaa
     7441 tttttgacac agtactatac gaaagaaaaa ctaggggaaa ataatacacg tattcaacct
     7501 tatatgactg aatcggccta ttctcaagaa ttgacaagtc aaaatgatgc catgaaccaa
     7561 gtgtataagg actatatttt ggattatcat tttgaaaaag cagatatctt tgtcaatcag
     7621 actacgaatc aagccattgc catggtctct tataatgtaa cttatgtatc tgatttaaag
     7681 aatgccaacc aatcaaagac aaaccaaaca gaaaccagaa cggttaattt gaactattcg
     7741 aaactacctg gtaagttatt ggtcaaccaa gtacaggttt ggaaatctgg gttagatgat
     7801 ctagataagg caactcctaa aactttagaa gaatcctcat ctgttccatc attgccgaat
     7861 actacgacaa aatgatgata ttttatgaat atagaggaat gtaagcaaat ttcaattctt
     7921 gatgtagcca atcgattagg tatctccttt aaacaagttt atgataaagc agtttactgg
     7981 atctatagtg gtgttaaagg acaatatgaa tattagaagg agaaaaaatg actaaacata
     8041 gttatgttgc gaaatttaag cgtaaagacg aaaccgtctt tacgaaaagg tttctagctt
     8101 cagatttatt tgaggctgtt gaacatgcgc tagagtatgc cactaagcga gatattctct
     8161 atctcgactt agggcatgca ggatagtagt cagtagaaag tagaggctgg gacaaaaagt
     8221 tctcagtcac aaaaaagcta gagatttcca attgtggaac tctagctttt taaattcgag
     8281 tcactctctt gttatatttc agaagatttt tggtcaattc tatttcacca agtctatcac
     8341 aatcatgcaa aaagcaacgg ttttatgaac tgcaccccaa aagttagaca gaaaaaatct
     8401 aactttcggg gtgtttttat tatgaaattg acttatgaag ataaggttca aatctatgaa
     8461 cttagaaacc aaggatatag cttagatcag ctttcaaata aatttgggat aaacatttct
     8521 aatcttagct acatgattaa attgattgat cgatacggaa tagaaatcgc taaaaaagga
     8581 aagaatcgtt actactctcc tgaattaaaa caagaaatga ttgataaagt cctatataaa
     8641 ggctattctc aagatagagt ttctcttgaa tatgctctcc caaatcgtgg gacgcttcct
     8701 aactggctcg cacactataa gaaaaacggg tatactattg ttgagaaaac aagaggaagg
     8761 ttatctaaaa tgggacgtaa gccaaagaaa aaactggaag aaatggaacg tcttcaagca
     8821 gaaaatgagt accttagagc ggagaatgca gttcttaaaa agttgagaga actccgattg
     8881 agggaagaaa aagagcaaga agaaaaacgg aaattgtccg aggattggta actgagtttt
     8941 ctttagatat gcttctaaag attattaagc ttgctcgttc aacctattat taccacttaa
     9001 aacagctgga tcaaaatgat aaggattatg acattaaagc tgaaattcaa gccattttta
     9061 ctgagcataa aggaaattac ggctatcgtc gaatgactct tgaattgaga aatcgaggaa
     9121 ttgtgattaa tcataagaga gttcaacgtc ttatgaaagt acttggttta accgctagaa
     9181 ttcgccgtaa acgtaagtat tcttcatatc aaggagaggt tggtatgaaa gcagagaatc
     9241 tcatccaacg ccagttcgaa gcatccaaac cattggaaaa atgctacaca gatgtaacag
     9301 aatttgccat tccagcaagc agccaaaaac tctatttgtc gccaatttta gatggcttca
     9361 atagtgaaat tatcgcctac aatctttcta agtcaccgaa cttgatacaa gtgaaagcta
     9421 tgttagaaca agcctttaca gagaaacatt acaaaaatac aattctccat agtgaccagg
     9481 gatggcaata tcaacatgat ttctatcatc attttttaga ggagaaagga atccaaccat
     9541 ccatgtcacg taaaggcaat agtccagaca acggcatgat ggaatccttc tttggcattc
     9601 ttaagtctga gatgttttat ggttatgaga agacgtttaa gtcaattgag catttggaac
     9661 aagcaattgc agactatatt aattattaca acaacaaacg cattaaggta aaactaaaag
     9721 gactcagtcc tgtacaatac agaactaaat cctttactta aattatttgt ctaacttttt
     9781 ggggtcagta cattatgccg ttgctttttg gagctaaagg acttttgtcc cagactcttt
     9841 atcccacgac gataacgata atgccttcaa atacgacaag aagaagtgtt agtaaaattt
     9901 gctttttcat gtgataatcc tcacttttgt ttttctttat tgtatgatat gatgaaagca
     9961 aatgaaaatt attcccatat atgcgtgatg gaggtgtagt atgaaaaaat ttggagaaat
    10021 ttttaaaaag tttcgagaat cgagaggatt acgattaaaa gacgtcgcaa aggctggtat
    10081 atcaacgtct cagctctctc gatttgagaa aggagaaaca gatttaacga tttcaaagtt
    10141 catgtttatt ttagatgaaa tcaatatgcc aatagatgaa tttatgtatg cggtccatga
    10201 ttttcataga gatgagttaa acgaactgtt atcgaaagta cgtcattttg tgtcaacacg
    10261 tgacgtagaa ggtatgaaaa aattacttta ttctcagatg gaactggaag ataggcgaga
    10321 aaaatttcat caaatcaata ttattttatt gaaaattcgt ctacaggatt tatcaggaga
    10381 aacttactat acaaaggatg atttgacata tttaacagat tatctcttta gtgtagaata
    10441 ctgggggtac tatgagttat tgattttctc gaatacttta gatgtattaa atcatgatgt
    10501 tttcatggtc ttagcaagag aaatgtttag gcgttctgat ttttacaaag aaattccaaa
    10561 taacagacga ttaatttcaa cgatgctttt aaatggatat attacatgtg ttgaaagaga
    10621 aaaatttatg gatgctttat attttgaaaa gcagctaaat caatgctttt ttattgagac
    10681 agaagtatat gaacgtttag tctttaagta tgcacaaaat ctttatcaat ataaagagga
    10741 tggaaatgtg aaagcaatta ttgaaatgaa gaagtgtgtt ggagcgatga aattagcagg
    10801 aagtcatcac ttagcaaaga cttatgaagg acatttagaa aaaattttag ctagtagtta
    10861 gaaaatgcaa atatgggaat attttattgt aagtgttgaa aagaaatata atcacagtat
    10921 catattcgaa aggagtacca aatatgtcta aagagcttga aaaagtcctt gagtctagtt
    10981 caatggcaaa aggtgacggc tggaaggtga tggcaaaagg tgacggctgg gagtgataaa
    11041 gtaatttatc ccataagtta agcagaggct atattttcct ctgctttttt agaaaggtat
    11101 tcaatatgat gacaatttca gaagattttt tatttagact agaaaagttt ggtggaattt
    11161 tgataaataa agtaactttt gaccgaattg agttagatga gagtgaagct tattttcttt
    11221 atttggttca aaatcatggt tttgaaattg ctacgtcctt ttttaagaaa gaaataaaag
    11281 cagggaaact agagcgagta ctcttattaa atatctattc tgataataat attgagggat
    11341 catcgaaaaa tcctgacgag actcttcaaa atgcgagaaa gcatgtagca aaattaaaaa
    11401 aacataacat attgagtttt ccgcttgaac tagtaatata ccccagtatg tactgtgatt
    11461 taaaatgtgg tttttgtttt ttagcaaatc gtgaagatag aaatgccaaa cctgctaaag
    11521 attgggaaag aattttgcgc caagcaaaag ataatggagt gttaagtgtt tcaattttag
    11581 gaggggaacc gactagatat tttgatattg ataatttgtt gatagcttgt gaagaactga
    11641 agataaagac tactataaca actaatgccc aattaataaa gaaaagtaca gtggaaattc
    11701 tagctaaatc taaatatatt acaccggttt tatctttgca gactttagat cctaaattaa
    11761 attttgaatt aatgggggtg agacctgata gacaaattaa attagcgaag tactttaaag
    11821 aggttggaaa aaaatgtaga attaatgcag tgtatacaaa gcaaagctat gagcagatta
    11881 tagaattggt tgatttttgt atagagaata aaatagatag attttcagta gctaattatt
    11941 ctgaggtaac aggatatacg aaaataaaga aaaaatacga tttagctgat ttgagaaggt
    12001 tgaatgagta tgttacagat tatataactc aacgggaagc taatttaaat tttgctactg
    12061 agggatgtca tcttttcacc gcttatccgg agttgataaa taattcaatt gaattttcag
    12121 agtttggcga aatgtattat ggatgtcgtg caaaatatac taatatggaa ataatgtcta
    12181 atggggatat cttgccttgc attgcttttt taggagttaa tcaaactaag cagaatgtct
    12241 ttgaaaaaga tttgttagat gtttggtatg atgatccgtt gtatggaggg attcgttctt
    12301 ttagaacgaa gaattctaag tgtttatctt gtggattgtt aaaaatttgc gagggtggct
    12361 gctatgttaa cttgattaag gagaagagtc caaaatattt tagagaccca gtttgtaact
    12421 tatgagtaag aagattttta atttatacgg aatgaatatg tttctatctg gattaccgta
    12481 ctactttgta ggaattttac tattaaagca cttaggtttt tcgttcacag aaatagctac
    12541 tttatcagtt attactgagc tatgtggctc agtttttgat attcctttaa gttatatttc
    12601 aagtaagatt ggttacaaga aaattttggc tatttcaaat ttattattaa ttttagcatt
    12661 atggggccta ttgtttggaa aatcaaatat aatatatatt tcagcgatat tttttggatt
    12721 gtcagaatca ttatcttcag gagttcttat ttcttataat tttgaaataa ttgatgacga
    12781 agttgtatat aaatcatttt tgaaaaatct caacacatta aaatatattt ttattgctat
    12841 tattacgatt atatctccac ctttattgca taggaattat atttatccta ttattatatc
    12901 cattgtattt gtaattttca gtttattata tttaatagga ttacccgaga ttaaaaagga
    12961 acaaaataat aaacaaaaat tttttagcct cgataatatt caaaatattc catggttatt
    13021 aataatatta ggagtagcat tctcaactct aattatgatt agcaattctt atgcagggat
    13081 attcttaaat gaacagggac tttcactaga tatgctggga attatactat ttatgtttaa
    13141 tatatctatg gctttgggga gttatctaaa aattaagttt gaagtaagct tgatgttacc
    13201 agtattagct atactcatgt tttttcaaac taatctaatc atccaaatta taatcctttt
    13261 attaatgcgt gttcttaatt ccaactacaa taatcatttt tattataaat ttaatatgtc
    13321 aatagaaaaa aatagagcag tatcatggtc agtatataat ttgtttattt cgattagttt
    13381 tatgttagct gatttcctag ctggtatttt tgctgataac tttagtatta ggagcaatta
    13441 tttaatattt ggtatagtag ctctttgttg cttagtatct tattcatttt ctaacagaga
    13501 gaaaagaact taaaagttgt atttctaatt catttgccaa attattgata gcacaattgt
    13561 ttgcaaattt agcagatatt ttctttagag tataagattg aatgatatgc ttggtattga
    13621 gtatatgtca gttatggtta tttgtcctac tggtagggct aatgacggta gtattttagc
    13681 agataaaaaa caatggtatc ctgtttttct tgatttaaca gagcggattt ctaaaggaga
    13741 gttcaaagtt aaatttaaaa ttgttcctcc taatgaaagt gatgtttttt tgacacatta
    13801 ttttccgctt gcattttata atagatcaga tttattagaa aatgtttggc atcaaaaagt
    13861 agatataaat tttgataagc caagggaaat atcttgtcaa gctggagtta gagcatgttc
    13921 aattaatcat aaaggagatg tatacgggtg tgacttgatg aatggtatag atgaattagt
    13981 tgctggaaat gttaaagaac aaaagtttag cgaaatttgg caccattctg ctgtatttaa
    14041 taaactaaga tcaattacat ttgatgatat ttctgggaaa tgttcagaat gtcccctacc
    14101 atggtgtggt gggggatgtc gatgcagtgc cttggaatta gatggaacgt tactgggctc
    14161 tgatttagcc tgcttttatg aacaaaaagg aggtggagta gtcgtatgaa agaacatttt
    14221 gtgataagag gtaagagaga tttcattgta aataaagtag cagatgaata cataggatac
    14281 gatctacttg attagagtac tattcatttg atgaaatagg agcagaaata ctttattgca
    14341 tttctaaaaa tttttcttta gacaagattg tagaactatt acagcaagat tatgaggtat
    14401 ctgctaatga ttgtaagcag gcaattattt catttttaga agaaactcct attttgcata
    14461 ttatttatgc aaatttagtt aaatctgatc tttacttaca tttgaagcct tttagagagg
    14521 aaaaatgata gattcaaaag aaattaacaa atttgccttt cccttagttt taacaaatat
    14581 tggtcaagta attattgggc agatagcatt gcattttgct gtgaacaatt cctcaattgc
    14641 tctgtcagga atttccatta ttcagaatct cttatttgct tttggtggac ttttaggagc
    14701 attcagtttg tcatttaata ttaaaagctc taaggcgtac tctaatcggc aaactaacag
    14761 gtttgatgat ttattgaaat caaatctaac cttagattta attatcggag ttgcctttgc
    14821 ggtttttgtc attatttttg gaaatgtaat cttgaagcag ctctatggat ttaaagggca
    14881 actattgtcc ttatccacca tttatttagt cttcatgtct ccatatatcg gattgacatt
    14941 attaaacttt tcgctgacaa atttattaag agttcaaaag aaaacaaaac caattatgtg
    15001 ggttggactt atcagttcat taatagatgt tgtgttaaat tatgtactgg taccacaaat
    15061 cggaattaag ggagcagcca tatcaacgat tgtatcctta gctttcatat cgcttagtta
    15121 cttgtttatg gtttatccaa tgattttgaa ggctttatcc attacatcta caactaaatt
    15181 tgaattaata acatttggta ttcctttggt tggtcaagaa attctggaga gtgttttgtt
    15241 tattatggtg tttgatgcct tgatgtcgag attaggagta gaattgttgg ctatttatgc
    15301 agttattagt caattgcttt caattgtgag tgtaccttct tttgtttatt cgacaaccgt
    15361 ttctatctat ttacctgaag cagagaaaat aggagaggtt aacgtatttt taaaaaacat
    15421 atttaaaaat tcataagatc cctgaaaagc gatattatag tcaggagaaa atgccttccc
    15481 taaaagttta tagtaattct taatctctct gaagttgatg attatataat tcaaattaat
    15541 tatctaaaaa atagttatat tcttgtatct ctttgaaata atctgctatc agtaatttct
    15601 ctttcattgt gagattatct ttagcgattt catataggaa agttcctata ttatttccaa
    15661 taacggatcc taaaataggt attggaatta cagcatgtcc taatattgag gataatgcac
    15721 taactgatac ttcaacacat aatatttgcg aatttagtaa aaattcttct tttgtgatta
    15781 agtttttacg gaatttgtat gcttctttag cgataccaaa tgaagcagtg cacaatgaac
    15841 ttgctactgc tgcaggagta gctgtgtaat tcgttagggc gtatatcgta atgcctcgag
    15901 tacttccttt tatagctcca attccactat ctttagaaat ttcaagacaa tcgtcttttg
    15961 taaactcact aatagttttc cctaagcgct ttttttaatt attgctgtta taaatgcagt
    16021 accccccttc tagagaagct gctatagcgg atatataggc tccctgtttt aaagtaggtt
    16081 tgcttttatc gtacatatct cttataatgc tagtatcaat atcctttata ttaccttttt
    16141 cattataaat agtggtattg atttgattcc tttgtacctc cctataacta actttcgaag
    16201 gctctatatc agaaagtttg atgctttctg tttcgaagaa ttgatttact tctttccatt
    16261 gcactcatgg tagatatctc gaatagtatt aagaatagct ttcttttgac gatgatagtt
    16321 agtccttgtc tttttaagat aattataata agcattggga tgaatattca tatgcaagaa
    16381 caaccaacgc aaaccaaaat cttctttata gttatcaata aaacgatatg cctctaatcg
    16441 atttcctttg caaagaatgc cgctgctttt tttaagaaat cattttcctt ttcaagctct
    16501 gccttttctt gacgtaattt acgaacctcc tccatgagtt caagctgtga tttttcttta
    16561 ttattagttt ggcattcttt gcgataatgt cttacccaat tagagattga ggcttgggat
    16621 acgccatatt cagcagctaa gctttttaat gttcatccgt cttgaatgtg cagtcgaaca
    16681 attttttatc gtgtttcgtc tggatagtgt ttcatgttat gtctcctatt ctaatgaata
    16741 gtttaactta ttaggtagga gtgttacaaa tttactatac cagaacagtc tagtttacta
    16801 tataagtctc taaatcgttc taaatgttta atatacaaat ctaattgttc tggttttaac
    16861 catattttcg ttggcataat tttttctctt ttcctaataa ataaaaaaga tagcacaaat
    16921 atttccttgt gctatctcaa catttagtta ataaaatatt ccttagtcat aattatattt
    16981 ttgctgattt ttagtcataa attaaattac ttctccagga ttgtcatttt accgtcaatt
    17041 atctgataaa ctttgtctgc catatctttt
//
