LOCUS       c00053_JAGZLH0..       10673 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAGZLH010000053.1 Streptococcus thermophilus isolate
            L3_131_368G1_dasL3_131_368G1_concoct_3_sub
            L3_131_368G1_scaffold_2017, whole genome shotgun sequence.
ACCESSION   JAGZLH010000053
VERSION     JAGZLH010000053
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 03:24:14
            Original ID  :: JAGZLH010000053.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10673
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..99
                     /locus_tag="ctg53_1"
                     /transl_table=11
                     /translation="QDLDYTLSDTDKIDNEITVIRRGKKKNFVLTY"
     protocluster    1..10673
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[224:10488]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      225..10488
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10673
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10673
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(225..1247)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_2"
                     /sec_met_domain="IlvN (E-value: 1e-77, bitscore: 248.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 4.3e-66, bitscore: 211.1,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQMEYEKDVKVPALDGKKIAVIGYGSQGHAHSQNLRDTGHDVI
                     IGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAV
                     GFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKD
                     IAMDWCKGIGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIETGFEVLTEAGYAPE
                     LAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEFGDYVSGPRVITEQVKENMKAVLAD
                     IQNGKFANDFVNDYKAGRPKLTAYREEAANLEIEKVGAELRKAMPFVGQNDDDAFKIYN
                     "
     CDS             complement(1323..1799)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_3"
                     /sec_met_domain="ALS_ss_C (E-value: 3.5e-29, bitscore:
                     90.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATETPDVSR
                     ITIIIDVNSHNEVEQIIKQLNRQIDVIRIRDITDVPHLEREVILVKVSAPTSKRAEILA
                     IIQPFRASVVDVAPSSITIQMTGDAEKSEALLRVIRPYGIKNIARTGATGFTRD"
     CDS             complement(1792..3492)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-47, bitscore:
                     150.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VEKIELEEARSGADLILDTLLELGISTIFGYPGGAVLPLYDAIYK
                     NEEINHILSRHEQGSLHEAEGYAKSTGKLGVALVTSGPGATNAITGIADAMSDSVPLLV
                     FTGQVATSGIGKDAFQEADIVGITMPITKYNYQIRDTADIPRIIREAVHIATTGRPGPV
                     VIDLPKDVVAKETTFINDPEINLPSYQPTLRPNEMQINKILKQLGKAKKPVIVAGGGVA
                     YSESAKELVAFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSYAANIAMTDADFMI
                     AIGCRFDDRLTGNPKTFAKNAKVVHIDVDPAEIGKIIAVDLPVVGDAKQALEMLLAEPV
                     VKNNTEKWIEKVKKDKERVRSYDKKERMVQPQAVIERIGELTDGDAVVVTDVGQHQMWT
                     AQYYPYQNERQLVTSGGLGTMGFGVPAAIGAKIANPDKEVILFVGDGGFQMTNQELAIL
                     NIYKVSIKVVMLNNHSLGMVRQWQESFYEGRTSESVFNALPDFQLMAQAYGIKSYKFDN
                     PETIDQDLEVIKEDVPMFIEVDISRKEHVLPIVPAGKSNHEMLGVKFNA"
     CDS             complement(3626..5116)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_5"
                     /sec_met_domain="ILVD_EDD (E-value: 1.7e-202, bitscore:
                     662.9, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VDDGIAMGHIGMRYSLPSRELIADAAETVINAHWFDGVFYIPNCD
                     KITPGMILAAMRTNVPAVFCSGGPMKGGVDMTGHQATLSSLFEAVGTYQSGDMSKEELD
                     YLEKNACPTCGSCSGMFTANSMNCLMEVLGLALPGNGTILAVSDERRELVRQAATKLMD
                     NIKNNVRPRDIVTKEAIDDAFALDMAMGGSTNTVLHTLAIAREAGIDYDLKDINDIAKK
                     TPYLSKIAPSSIYTMHDVHEAGGVPAIINQLIKKGAIKGDRITVTGKTLKENVAGAKIK
                     NEEIIHPIEQPILPVGGLSILYGNIAQDGAVIKVGGVDPSVKTFRGKAICCDSQAQALE
                     LIDNGTVKKGHVVVIRYEGPQGGPGMPEMLAPTSKIVGRGLGKDVALITDGRFSGATRG
                     IAIGHVSPEAAEGGNIALIEDGDEIVIDLPNRTLDLLVDDVTLEARRKHLKPFKSKISS
                     GWLRRYTAFAKSANIGGTLMSNEEFEERKAERQAQEKN"
     CDS             complement(5182..5346)
                     /locus_tag="ctg53_6"
                     /transl_table=11
                     /translation="MRSDMIKVGVDKAPARGLLYATGQVKSSKDMQKPFMLFVILILIL
                     FQDMSTYVN"
     CDS             complement(5516..7183)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dak2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_7"
                     /sec_met_domain="Dak2 (E-value: 3.2e-44, bitscore: 140.3,
                     seeds: 138, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSKITTSLLQEMVQAAATRLGKQAEYVNSLNVFPVPDGDTGTNMG
                     MTMDNGAKAVADQTASTVGEVGQILSKGLLMGARGNSGVITSQLFRGFCQSIKDKTELD
                     GQDLAHAFQSGVEVAYKAVMKPVEGTILTVSRGAASAAIKKTESTNDAVEVMRAALDGA
                     KAALAKTPEMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFQATPATMTEMI
                     NAEHHKAVAGHVATEDITFGYCTEIMIGLKQGPTYVKDFDYEEFQNYLSNLGDSLLVVN
                     DDEIVKVHVHTEDPGLVMQEGLKYGALVKVKVENMRNQHDAQVQKAAAIQASPSAPKDF
                     AFIAVVAGDGLADIFKSQGVDYVISGGQTMNPSTEDIVKAIEQVNAKNVIILPNNKNIF
                     MAAQSATEVVDVNAAVVETRTVPQGFRSLLAFDPNQSIEANVEAMTVSLSDVTSGSVTL
                     AVRDTTIDGLEIHENDILGMVDGKILVSTPDMDQALLDTFEKMIDEDSEIVMIYVGEEG
                     NQEQAQALAEKLEEIHEDIEVEIFQGDQPVYPYIFSVE"
     CDS             complement(7183..7548)
                     /locus_tag="ctg53_8"
                     /transl_table=11
                     /translation="MTVKINTKDGQIELSDDVIATVVGGSTTEIFGVVGMASKSAIRDN
                     FQALLGKENYAKGVVVKSTDAGIAVDVYTVMSYGVKISEVSKNIQERVKFNLENQLGIK
                     TEAVNVYVQNIKVVGEN"
     CDS             complement(7658..8947)
                     /locus_tag="ctg53_9"
                     /transl_table=11
                     /translation="MTETKKILNIALPAMAENLLQMLMGIVDSYLVAQVGIVAISGVSV
                     ANNIITIYQAIFIALGASSASVIARSLGKGDVKATNRDIWDAIIITLALSIVLGLLSIF
                     FGGAILNLLGTEQSVTQAGSLYLAIVGGGVIFLALMTTFGNILRAKGRPRISMVVSLLT
                     NLLNALLSSLAIFVGHWGIIGVATATVFSRLVGTVILWTAMKLDVKQFEVTKPFNKELL
                     GIVLPAAGERLMMRAGDVVIVAIIVTFGTAVVGGNAIGENLIQFNYMPGMGVATATVIL
                     VANSLGRGDTAQMKRIIRESYWISTFLMVLVSGSILLFGRGLSSFFTDNKVAIAASQVV
                     ILYSFLGNPVTSATLVFTAAWQGLGKAKIPFYATTVGMWLIRIFSGYFLGVSLRMGLAG
                     VWIATVVDNIWRAIFLYVMYRHYLAKRQFR"
     CDS             complement(9004..10488)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_10"
                     /sec_met_domain="PALP (E-value: 8.4e-17, bitscore: 50.8,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVYQSTRDENNKVTASQAILQGLATDGGLFTPLTTPEVTLDFD
                     HLKDASYQEVAKLVLSAFLDDFTEEELDYCITNAYDDKFDTAAIAPVVKLQNHYNLELF
                     HGPTIAFKDMALSILPYLLTTSAKKQGVDNKIVILTATSGDTGKAAMAGFADVPETEII
                     VFYPKDGVSKIQELQMTTQAGANTHVIAIDGNFDDAQTNVKRMFNDVDLREKLLTHHMQ
                     FSSANSMNIGRLVPQVVYYVYAYAQLVKAGHIKNGDKVNFTVPTGNFGNILAAYYAGQI
                     GVPVGKIICASNENNVLTDFFATGTYDKKRDFKVTTSPSMDILVSSNLERLIFHLLGND
                     AVKTKELMDALVTKGEYTLADADKGILDLFAAGFATEDETAAEIKRVYEEDKYIEDPHT
                     AVASAVYEAYVQKTDDHTPTVIASTASPYKFPRVAVSAVTGKDSGDDFKAVEDLHQLSG
                     VDIPAAVDGLERAEVRHKTVVAAADMQKAVESYLGV"
ORIGIN
        1 caagacttgg attacactct ttcagatacc gataagattg acaatgaaat cactgttatc
       61 cgtcgcggta agaagaaaaa ctttgtttta acttactaat ttatgaccat tctcactccc
      121 tagtggagtg atttttttta cacacaaagc cataagctta acacctaatc actttcttaa
      181 gaacacaaaa aaccagcact aggctggttt ttgagactat cacattagtt atagattttg
      241 aatgcatcat cgtcgttttg accaacgaat ggcattgctt tacgcaattc agcaccaact
      301 ttttcgattt caaggttagc agcttcttca cggtaagcag taagttttgg acgtccagct
      361 ttgtagtcgt taacgaagtc attagcgaat ttaccatttt ggatatcagc aagaactgct
      421 ttcatgtttt ctttaacttg ttcagtgata acacgtggac ctgatacata gtcaccgaat
      481 tcagcagtgt tagaaattga ttgacgcatt ttcttgaatc caccttcgta aatcaagtca
      541 acgattaatt tcatttcgtg aagtacttca aagtaagcca attctggtgc atatccagct
      601 tcagtcaaga cttcaaaacc agtttcgata agggcagtca aaccaccaca aagaactgct
      661 tgttcaccaa acaaatcttc ttcagtttct tctttgtatg ttgtttcaag aagacctaca
      721 cgtgctgcac caataccttt acaccagtcc atagcgatgt ctttagcgtt acctgtggca
      781 tcttggtata ctgcgtaaag ggcaggtaca ccaaaacctt cttcaaatgt acgacgtacc
      841 aagtgacctg gtcctttagg tgcacacata aatacatcaa catctgctgg tactttaata
      901 aattcaaagt ggatgttgaa accgtgagca aaaccaacag cgttaccagc ttcaagattt
      961 ggagcgattt ctgcttcgta aagttcttgt tggatttcgt ctggagccaa aatcatgata
     1021 acatcagcca atttagttgc ttctgctact gtgtaagtat caaaaccatc ttctttagct
     1081 ttatcaaatg atttacctgg acgaacaccg atgataacat cgtgacctgt atcacgcaag
     1141 ttttgtgagt gagcgtgacc ttgtgaaccg taaccaataa cggcgatttt tttaccatca
     1201 agtgctggta cttttacgtc tttttcatat tccatttgaa ctgccatagt agtatatctc
     1261 ttttctaaaa taatatttaa ttgccttttt aaggctaggt taacaaattt ataatggatt
     1321 ttttaatcac gggtaaatcc agtagcaccc gtacgagcaa tattcttgat accgtaaggt
     1381 cgaataactc gtagaagcgc ctcactcttt tcagcatctc cagtcatctg gatagtgata
     1441 gagcttggtg caacatccac caccgaagca cggaaaggtt gaatgattgc caaaatttca
     1501 gcacgtttag aagttggtgc cgacacctta accaagataa cctcacgttc caagtggggt
     1561 acatcagtga tgtcacgaat gcgaatcaca tcaatctgac gattaagctg tttaataatc
     1621 tgctcaacct cattatgaga attcacatca atgataattg taatacgtga aacatcagga
     1681 gtttccgttg ctccaacgga aatactctca atattgacct gacggcgtga aagcactcca
     1741 gtgaaacggt taagaacacc tgatcggttc tgaagtttag ctgttaacat tctacgcatt
     1801 gaactttacc cccaacattt catgattact cttaccagct ggaacaattg gcaaaacatg
     1861 ctctttacga gaaatatcaa cctcgatgaa cattggcaca tcctctttga taacttccaa
     1921 atcctgatca atcgtttctg gattatcaaa cttataagac ttaatcccat aagcttgagc
     1981 catcagttga aaatcaggaa gagcattaaa gacagactct gatgtacgcc cttcgtagaa
     2041 ggactcttgc cattgacgta ccataccaag tgagtggtta ttcaacataa caaccttgat
     2101 tgacaccttg taaatattta aaatagccaa ttcttggttc gtcatttgga aaccaccatc
     2161 accaacaaag aggataactt ctttatcagg attagcaatt ttagcaccaa ttgctgctgg
     2221 aacaccaaat cccatagttc caaggccacc tgatgtcacc aattgacgct cattttgata
     2281 tggataatac tgagctgtcc acatttgatg ttgcccaacg tcagtgacaa caactgcatc
     2341 accatcggtc aattcaccga tacgctcgat aaccgcctga ggctgtacca tacgttcttt
     2401 cttatcgtaa gaacgtacac gctctttatc ttttttgact ttttcaatcc atttttcagt
     2461 gttattctta accactggtt ctgctaagag catttcaaga gcttgcttgg catcaccaac
     2521 aactggcaaa tctaccgcaa taatcttgcc aatctcagcc ggatccacat caatatgaac
     2581 aacctttgca ttcttagcaa atgtttttgg attacctgtc aagcggtcat caaaacgaca
     2641 acctatggca atcataaagt cagcatcagt catagcaata ttagctgcat acgaaccgtg
     2701 cataccaccc atacccaaaa agaggggatg actagtagca attgttccct gacctagaag
     2761 acttgtaaca acaggaattt ggtagcgttc tgcaaaagca actagctcct tagcagattc
     2821 agaataagcc actccacctc cagctacaat aaccggcttc ttagctttac ccaactgttt
     2881 caagatttta ttaatttgca tctcgtttgg tcttagcgtc ggttggtaac ttggaagatt
     2941 gatttcagga tcgttgatga aggtagtttc cttagctaca acatcttttg gaaggtctat
     3001 aacaaccgga ccaggacgcc ctgtcgttgc gatatgaacc gcttctcgaa taatacgagg
     3061 aatatcagcc gtatcacgaa tctggtagtt gtatttggta attggcatgg taattccgac
     3121 aatgtcagct tcttggaagg catccttacc aatacctgat gttgctacct gacccgtaaa
     3181 gaccagaaga ggtacactat cactcatagc atctgcaatc ccagtaatag cattcgttgc
     3241 accgggacca ctcgttacaa gagcaacacc aagtttccca gttgatttag cataaccttc
     3301 agcttcatgc aggcttcctt gctcatgacg agacaaaata tgattaatct cttcattttt
     3361 ataaatagca tcatacaaag gaagaaccgc tccgccagga tacccaaaaa tggttgaaat
     3421 cccaagttcg agaagtgtat caagaatcaa atcagcacca gagcgtgctt cttcaagttc
     3481 aattttctcc acatggacct cctttagcaa ttgttttttt caaattatct aaaaattcaa
     3541 aaccttgtat actatactaa catttttaac taaatttgca agggtttcag agaaaaatat
     3601 cacaaactct tcggaaataa tattcttagt ttttttcttg tgcctgacgt tctgctttac
     3661 gttcttcaaa ttcttcatta ctcataagag ttcctccgat attagctgat ttagcaaaag
     3721 cagtgtaacg gcgtaaccag ccacttgaga tcttagattt gaaaggcttc aagtgcttac
     3781 ggcgtgcttc aagtgtcaca tcatcaacga gcaaatcaag ggtacgattc ggaagatcaa
     3841 tcacaatttc atccccatct tcaatcagag ctatattgcc accttccgca gcttctggag
     3901 atacgtgacc aatagcaata ccacgagttg ctcctgagaa acgaccatca gtaatcagag
     3961 caacatcctt gccaagaccg cggcctacaa tcttagaggt tggcgctaac atctctggca
     4021 taccaggacc accctgagga ccctcgtaac gaatgacaac aacatggccc ttcttaactg
     4081 ttccattatc aatcaattca agagcttgag cttgtgaatc gcaacaaata gccttaccac
     4141 ggaaagtttt aacggatgga tctacaccac caaccttgat aacagcccca tcctgagcaa
     4201 tatttccata aaggatagac aaaccgccaa ccggtaaaat aggttgctcg attggatgga
     4261 taatttcttc atttttgatt ttagcaccag ctacattttc ttttaaggtt ttaccagtaa
     4321 ccgtaatacg atcaccctta atggcacctt tcttgatcaa ctgattaata atggctggaa
     4381 caccacctgc ttcatgtaca tcatgcatgg tatagatgct ggagggagca attttagaga
     4441 gataaggtgt cttcttagca atatcattaa tgtccttaag gtcatagtca ataccagcct
     4501 cacgcgcaat agcaagggta tgaagaacgg tattggttga accacccata gccatatcta
     4561 gagcaaaagc atcatcgatg gcttctttgg tcacaatatc acgtgggcga acattatttt
     4621 tgatgttatc cattaatttt gtggctgctt gacgaaccaa ttcacgacgt tcgtctgaaa
     4681 cagctaggat agtaccgtta cctggaaggg caagacccaa aacttccatt aaacagttca
     4741 ttgagttagc agtaaacatt cctgaacatg aaccacaagt tggacaggca tttttctcta
     4801 aataatcaag ctcttccttg ctcatatctc cagactggta agtacctaca gcttcaaaca
     4861 agcttgataa agtagcctga tgaccagtca tatcaacgcc acccttcata gggccacctg
     4921 aacagaatac cgccggcaca ttagtacgca tggctgccaa aatcattcct ggtgtaatct
     4981 tatcacagtt tgggatatag aacacaccgt caaaccagtg ggcattaata acggtttctg
     5041 cagcatcagc aattaattct cgtgaaggga ggctgtaacg catcccaata tgtcccatgg
     5101 caatcccgtc atccacacca atagtattaa actcaaaagg aataccacca gcttcacgga
     5161 tagcctcctt ggcaatatcc gctaattcac gtaggtggac atgtcctgga acaatatcaa
     5221 tataagaatt acaaatagca taaagggctt ttgcatatcc ttagaagatt taacctgtcc
     5281 agtcgcatac aaaaggccac gtgctggtgc tttatcaaca ccaactttga tcatatcact
     5341 tctcatgatc ttaccttcaa tctataaaat ttcttacaac atatgttacc actttggaag
     5401 gtaatgtcaa ttaattttcg gaatatttct gtaattccaa aaaatgactt tttagtatcg
     5461 aaactattta aacaaaaaag gaagccctaa gacttccaaa atgattattt ttaaattatt
     5521 caacgctaaa gatatatggg tacacaggtt ggtccccttg gaagatttca acttcgatat
     5581 cttcatgaat ctcttccaat ttttcagcga gcgcttgtgc ttgttcttga ttgccttctt
     5641 cgccgacgta aatcataaca atttcgctgt cttcgtcaat catcttttca aaggtatcaa
     5701 gaagggcttg atccatatct ggtgtagata caagaatctt accgtctacc ataccaagga
     5761 tatcattttc atgaatttca aggccgtcaa tagttgtgtc acgtactgcc aaagtcacgc
     5821 taccacttgt tacatccgaa agactaactg tcatagcttc aacattagct tcgatacttt
     5881 ggtttggatc gaaagcaagc aagcttctaa agccttgtgg aactgtacgt gtttcaacaa
     5941 cagccgcatt aacatccact acttcagtgg ctgattgtgc tgccataaag atgtttttat
     6001 tatttggcaa gatgataaca ttcttggcat taacctgctc aatagcctta acgatatcct
     6061 ccgttgatgg gttcattgtt tgaccacctg aaatcacata gtcaactcct tgtgatttaa
     6121 agatatctgc aagtccatct ccggcaacaa ctgcaataaa ggcaaagtct ttaggagcag
     6181 aaggcgaagc ttgaatggct gctgcttttt gaacttgtgc atcgtgttga ttacgcatgt
     6241 tttcaacctt aactttgaca agagcaccat atttaaggcc ttcttgcatg acaagacccg
     6301 gatcctctgt atggacgtga acttttacaa tttcatcgtc attaacaaca aggagagaat
     6361 ccccaagatt actcaagtaa ttttgaaact cctcatagtc aaagtctttc acataagttg
     6421 gaccttgttt gagaccaatc atgatttccg tacagtatcc gaaggtaata tcttctgttg
     6481 caacatgacc tgcaactgcc ttatgatgtt ctgcattgat catctctgtc atagtagcag
     6541 gtgtcgcttg gaagtcctct gaagcgatat actcacctgt tagggctgac aagaaacctt
     6601 cataaataaa gactaaacct tgaccacctg agtctactac accaacttct ttcaatactg
     6661 gaagcatctc tggtgtctta gccaaagcgg ccttagctcc gtcaagagct gcacgcataa
     6721 cctcaacagc atcattagta gactcagttt tcttaatcgc tgctgaagct gcaccacgtg
     6781 atactgtaag gattgttcct tcgacaggtt tcataacagc tttatacgca acttcaacac
     6841 ctgattggaa ggcgtgagct agatcttggc cgtcaagttc cgttttatcc ttgatgcttt
     6901 gacaaaaacc acgaaacaat tgtgacgtaa taacacctga gttaccacgg gcacccatca
     6961 agagaccttt agacaaaatc tgaccaactt caccaactgt tgaagctgtt tgatctgcga
     7021 cagctttggc tccattatcc atagtcattc ccatgttagt tccagtatct ccatctggta
     7081 ctgggaagac attgagtgaa ttcacatatt ctgcttgctt acctagacgc gttgctgctg
     7141 cttggaccat ctcctgaagt aagcttgttg taattttaga cactagtttt ctcctacgac
     7201 tttgatattt tgaacgtaaa catttactgc ctctgtcttg ataccgagtt gattctcaag
     7261 attaaatttt acacgttctt gaatattttt tgaaacctca ctaatcttaa caccataact
     7321 cataacagtg taaacatcca cagcgatacc tgcatcagta gatttcacga caactccttt
     7381 tgcgtagttt tcttttccaa gaagtgcttg aaaattatct cggatagcac tcttacttgc
     7441 cataccgaca acgccaaaaa tttctgttgt tgaaccgcca actactgttg cgatgacatc
     7501 atctgacaat tcgatttgac catcttttgt attgattttt acagtcataa ttactacctc
     7561 aaaaagtttt tatcagttta ttctatcata ttcgagacta cttgtaaaaa ataagaagaa
     7621 gatacctttt aaatagaagc atctccccat catgttatta tctaaactgt ctctttgcga
     7681 gataatgacg atacatcacg tagagaaaga tcgcacgcca tatattatca acaaccgttg
     7741 caatccagac acctgcaagg cccattctca aactcactcc taggaagtag cctgagaaaa
     7801 ttcggattag ccacatccca acagtcgttg cgtaaaaagg tatcttggcc ttcccaagac
     7861 cttgccaggc tgctgtgaag actaaagtcg ccgaagttac gggatttcct aggaatgaat
     7921 aaagaataac gacctgacta gcagcaatag ctactttgtt atctgtaaag aaacttgaca
     7981 agccccggcc aaaaagtaag atgcttccag aaaccaaaac catcaagaaa gttgaaatcc
     8041 agtaagactc tcgtataata cgcttcatct gcgccgtatc ccctcgcccc aaactattag
     8101 caaccaagat aaccgtggct gtagccaccc ccatacctgg catatagtta aactggatga
     8161 gattttcacc aatggcatta ccaccaacaa ctgctgtacc aaaggtaacg atgatggcta
     8221 ctataacaac atcccctgca cgcatcatca accgctcacc tgctgctggt agaacaattc
     8281 ccaacaactc cttgttaaaa ggtttggtaa cttcaaactg tttcacatcc aatttcattg
     8341 cagtccataa tatgactgtc ccaactaggc gagaaaaaac cgtagctgta gctaccccaa
     8401 taatccccca atgtccaaca aaaatagcca aagaagatag aagagcgtta agaagattgg
     8461 tcaaaagact gacgaccatg gaaatacgag gacgtccctt ggctcgtagt atgttaccaa
     8521 aggtagtcat caaagccaga aagatcacac ctccaccgac tatagccaaa tagaggctgc
     8581 cagcctgagt cacagattgc tcagttccca gaagattaag aatggctcca ccaaaaaaaa
     8641 tggagagtag acccaagacg atactaagag caagagtaat aataatagca tcccagatat
     8701 ctctgttagt cgctttaacg tctccttttc ctaggcttct agcaatgaca ctagcacttg
     8761 aagcccccag cgcaatgaag atagcctgat aaatcgtaat gatattattg gccacggaaa
     8821 cccccgatat agcaacaata ccaacctgag ctactaggta agaatcgaca atccccatca
     8881 acatttgtaa gaggttctca gccatagccg gtaaggctat gtttaaaatt ttctttgttt
     8941 ctgtcataat attttctttt atattgataa aaatagggct gatttctcag ctcctatttt
     9001 tttttataca ccaagatagc tctcaactgc tttctgcata tcagctgcag caacaactgt
     9061 tttatggcga acttctgcac gttcaagtcc atctacagca gctgggatat ctactcctga
     9121 aagttggtgc aagtcttcta ccgccttgaa gtcatcacca ctatctttac cagtaacagc
     9181 tgaaaccgct acacgtggga acttgtatgg actagctgtt gaagcgataa ctgttggtgt
     9241 gtgatcatct gtcttttgaa cgtatgcttc gtaaacagct gaggcaaccg ctgtgtgagg
     9301 atcttcaata tacttgtctt cttcataaac acgtttgatt tcagcagctg tttcatcctc
     9361 agttgcaaat cccgctgcaa acaaatcaag gataccttta tctgcatcag ccaaagtgta
     9421 ctcaccttta gtcacaagcg catccataag ctctttagtc ttaaccgcat cattaccaag
     9481 gagatggaaa atcaagcgtt ctaggttaga agataccaaa atgtccatag aaggacttgt
     9541 cgttaccttg aagtcacgtt tcttgtcata agtacctgtt gcaaagaagt ctgtaaggac
     9601 attattttcg ttagaagcac agattatttt accaactgga acaccaattt gacctgcata
     9661 gtaagccgcc aagatgttac caaagtttcc tgttggtact gtgaagttaa ccttatcccc
     9721 atttttgata tgacctgcct tcaccaactg cgcataggca tacacatagt aaaccacttg
     9781 tggtaccaaa cgaccaatgt tcattgagtt agctgatgag aattgcatat gatgagtcaa
     9841 caatttctca cgcaaatcaa catcgttaaa catacgtttc acatttgttt gggcatcatc
     9901 aaagttacca tcaattgcaa taacatgagt attagcacct gcttgagttg tcatttgcaa
     9961 ttcttggatt tttgaaacgc catcttttgg ataaaagaca ataatttcag tttcagggac
    10021 atctgcaaaa ccagccatgg cagctttacc agtatcccct gatgtcgctg tcaaaataac
    10081 aatcttgtta tcaacacctt gtttcttagc tgatgttgtt agcaaatagg gcaatattga
    10141 aagcgccata tctttgaaag caatggtagg accatgaaaa agctcaaggt tgtaatggtt
    10201 ttgaagtttg accactggag caatggcagc tgtatcaaac ttatcatcat aagcatttgt
    10261 gatacagtaa tccaattctt cttcagtaaa atcatccaag aaagcagaca aaactaattt
    10321 agcaacttct tggtaagaag catctttcaa gtgatcaaag tctaaagtaa cttcaggtgt
    10381 tgtcagcgga gtgaacaagc caccatctgt tgccaatcct tgaagaatag cctgactagc
    10441 tgttacttta ttgttttcgt cacgtgttga ttggtataca agtgtcatgg taaatcctct
    10501 tttttagata gtctttgact ctattgtagc ataattgtca gaaaatttct acacatattg
    10561 taacttgtga gagaatcatt cggatttcac ttgtttaatt tcatttaaat atcggaaaaa
    10621 atccggaatt tctatcccag attttctttt aaaatttatc tttggtatca ttc
//
