LOCUS       c00012_JAHADA0..       16540 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHADA010000030.1 Streptococcus salivarius isolate
            L2_047_000G1_dasL2_047_000G1_metabat.metabat.51
            L2_047_000G1_scaffold_1502, whole genome shotgun sequence.
ACCESSION   JAHADA010000030
VERSION     JAHADA010000030
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 19:10:09
            Original ID  :: JAHADA010000030.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16540
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16540
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2670:11540]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2671..11540
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..16540
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16540
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(41..337)
                     /locus_tag="ctg12_1"
                     /transl_table=11
                     /translation="MTGLKWFAGGKERREQAVAIIDEVIETIGDKPDYADLKQVLHSYR
                     TELADSRSATPYILSRMSLEISEVVRKDQLTLSPFIEERMADLRKLLAIRYGY"
     CDS             complement(376..582)
                     /locus_tag="ctg12_2"
                     /transl_table=11
                     /translation="MVILQKISSAVLRSLRVVSAILGVVIGNIALNPLSSQHPIWIWLP
                     FRTYSYFLGRWLLNDYQGAILKM"
     CDS             complement(718..909)
                     /locus_tag="ctg12_3"
                     /transl_table=11
                     /translation="LEQSVFSRKYIIFILQVILAVCIQCVITFFWHQERTFLFYILSLY
                     VSLSFSDDLSQLIFRNEK"
     CDS             complement(1106..1507)
                     /locus_tag="ctg12_4"
                     /transl_table=11
                     /translation="MKLKNISPRVLRFFRVATAILAVFLISTSISLYKSKTSPEIWLAV
                     GALALVVIFVNGLLYCMLKKRSDSVNPLIIWQSFIVFLVISFLVLCVEFYTLLTFSDTT
                     DRIVLVVLMLLLILCDFLAYLQVKKYFKR"
     CDS             complement(1633..1803)
                     /locus_tag="ctg12_5"
                     /transl_table=11
                     /translation="MLIFDVPEVKLFLLMIAEIVLYLIVFLCNRKDKDMYIRLFKVSVL
                     MTLLYYISSRI"
     CDS             complement(1837..2004)
                     /locus_tag="ctg12_6"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIGMGLANLFRSLDAVHHTINLLGLTLLLYSL
                     LFKKWVQFKK"
     CDS             complement(2079..2204)
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MFDLKSYILGMAFMAVMSFLDKPIMSFLEKHKVTNSAKKKF"
     CDS             complement(2488..2637)
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MYLLAIFLLGFGIANLFRNLDFVHHIINLVGLALITYSLIFSKWE
                     RLKK"
     CDS             complement(2671..2850)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_9"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.3e-14,
                     bitscore: 44.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTQTMNNFETLDLEALANVEGGGWVKCYAGTIGSALVGSAGGPV
                     GYWGGALVGYATFC"
     CDS             complement(3010..4755)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     284.8; E-value: 8.1e-87)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 306.7; E-value:
                     5.3e-93)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALAFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASLILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGILSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVVIIEKTRALLSDINAKLSESIEGIRIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSMSLDSLFLRPAMSLLKLLGYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRGTDAKVTEGNI
                     RFENVSFSYDGKHQILDSISFSVNKGETIAFVGSTGSGKSSIINVFMRFYEFQSGRVLL
                     DGVDIRDYSQAELRKNIGLVLQEPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYEAPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     AMEGA"
     CDS             complement(4748..6508)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 387.3; E-value:
                     2.1e-117)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_11"
                     /transl_table=11
                     /translation="LFFKESIIAKLWWFFKLEKRRYIVGILALSLVSVLNLIPPMVMGR
                     VIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILATSYRLGQIMRSRLFEHF
                     TKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDASITALVTLITMFFSISWQ
                     MTLVAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQEA
                     ELQSFQETNKMTFKKNMHTMKYDSLFDPLVLLFVGSSYVLTLLVGAFMIQAGQITVGNL
                     VTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIENLLEQESDVQDPAHPLPSIENGRL
                     EYAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGQTGSGKTALVKLLLREHDVNQGAIYLN
                     GHNIRDYRLSDLRSLMGYVPQDQFLFASSILDNICFGNPDLSFDKVEEATKLAQVYDDI
                     KDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILDPDILILDDSLSAVDAKTEYAIIDN
                     LKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHEDLLAQGGWYAKTYESQQL
                     EMEGGEEDDA"
     CDS             complement(6558..6953)
                     /locus_tag="ctg12_12"
                     /transl_table=11
                     /translation="MTMVKADTYQSGRDADIMRERGQVWNYSEVKREPQLANYNTDGRY
                     LSEATNFELFNFVREYKTSDEIRRIWNPKKDESVIHDKDSYSIDDGHKVYNFDSFAYQL
                     PESTDFGKLTYIGYFQLEDGTIYRYWK"
     CDS             complement(7106..7633)
                     /locus_tag="ctg12_13"
                     /transl_table=11
                     /translation="MFQLTTWVDKDGELTLKGRKLSQVLVCAYLLCLVLLCWTPQYGLV
                     EGVETPGIQHFGRVVVLLTPFNSFTNFYQLDSLKEIVFVLGQNVTNIFLLSPLILGLLA
                     LYPRFRSWQKVLLATFIMSLTIEVGQVILDLLIDANRVFELDDLWTNTLGGLVALAAYR
                     LLVKLIQTHFKE"
     CDS             complement(7635..8804)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_14"
                     /sec_met_domain="PF04055 (E-value: 5.3e-21, bitscore: 66.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVTTQAKPERRKRQKLEDMEGYKPSIYGLTRDELIDWAMEHGE
                     KKFRATQIWDWLYKKRVQSFEEMTNISKDFIAKLNENFCVNPLKQRIVQESKDGTVKYL
                     FELPDGMLIETVLMRQHYGLSVCVTTQVGCNIGCTFCASGLIKKQRDLTAGEIVAQIML
                     VQKYFDDRGDGERVSHVVVMGIGEPFDNYDNVLRFLRTINNDNGLAIGARHITVSTSGL
                     APKIKEFANEGVQVNLAVSLHAPNNDLRSSIMRINRSFPLEKLFEAIEYYIQTTNRRVT
                     FEYIMLNEVNDHPENAQELADLTKKIRKLSYINLIPYNPVSEHDQYSRSTKERVAAFYD
                     VLKKNGVNCVVRQEHGTDIDAACGQLRSNTMKRDRQKAVAEASGKSEGK"
     CDS             complement(8808..9536)
                     /locus_tag="ctg12_15"
                     /transl_table=11
                     /translation="MRKEILPEMFNYNKYPGPDFVYVADLLKSDACQFTVLENHKDALD
                     ATRFGQRFSEIMLKYDYIVGDWSNDQLRLKGFYEDERPNTRKTDRISRLSEYLREYCAF
                     GCAYFILKNEEPQLIVFEEETEPRRKRRRSNNRRNASQESRDRERNASQKNKGQKASAK
                     QKPDKSKRRDRDQEGPNFEKIKRRPKFKSRSEDGGRERKSNFKKSQKQAPKSKGQNTPS
                     KKQSQTKSDGQHFTIRKKGN"
     CDS             complement(9591..10991)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283:2`,3`-cyclic-nucleotide 2`-phosphodiesterase
                     (Score: 205.7; E-value: 2.2e-62)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_16"
                     /transl_table=11
                     /translation="MIVKFFYSKSATIGVMKDTIRILHINDLHSHFEQYPQLKRAVDDL
                     SQTDRELIKVDLGDNVDKSHPLSDATAGRFNVALMNELGIDYATIGNNEGIGLAKDELD
                     CLYEQAKFQPIIGNLKDEGRQPEWAKSYLIHRTKAGTNIAFLAYTFPYYITYAPNGWQV
                     LEPMARLEEDLARPEVKDADIVVVLSHLGVRYDEQIAETYPQVNLVIGSHTHHLFEEGK
                     LVNETYLAAADRYGYYLGCIDLTVENGRLIECQIEAIPTKSYILDLDKEDETFIKAMRE
                     EGHRRLAQKKVANLGRELDFDETCQLVLQAVCQETDSQLTLLNTGLIMKTLGPQVTMAD
                     LQEALPHQMRMARLVVTGQELKEICQEVFTKAELLKNQAIKGMGFRGKTFGEVITGNFA
                     YKNGNLLYNRRVVDSNEKFSLVLVDQYYFASYFPTIKEKEVTLLFPDLLRELVAKYLGK
                     NGANWDKI"
     CDS             complement(11036..11272)
                     /locus_tag="ctg12_17"
                     /transl_table=11
                     /translation="LVMVLKMGLLMDLFVVIRRLLSQFFGQIVLALLIYGLIFFAWQHF
                     RGEIFSIVCIYVSISLADDVYHLAEEYVKKKVN"
     CDS             complement(11220..11540)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_18"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 8.4e-10,
                     bitscore: 30.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLFCWLSIYNTIIAFEKRLKNILKEVVLMTTQIINNFNSLNSE
                     DLSTVKGGACSFWGATAAVGVGAVGGAIKGGIQTGTWQGAALKGIGYGIKDGITYGLIC
                     RY"
     CDS             complement(11930..13273)
                     /gene_functions="other (smcogs) SMCOG1122:ATP-dependent RNA
                     helicase (Score: 333.6; E-value: 3.4e-101)"
                     /gene_kind="other"
                     /locus_tag="ctg12_19"
                     /transl_table=11
                     /translation="MSFKDFNFKTFIQEALDEIKFKEPTPVQQKLIPVVRSGRDLVGES
                     KTGSGKTHTFLLPIFEKLNPKSGDVQVVITAPSRELATQIYQATKQIAKHSETEIRVVN
                     YVGGTDKQRQIEKLKVAQPHIVIGTPGRIYDLVKSGDLAIHKAHTFVVDEADMTMDMGF
                     LDTVDKIAASLPKEVQILVFSATIPQKLQPFLKKYLTNPVMEQIKTSTVIADTIDNWLV
                     STKGRNKNEQILEMLKGMQPYLAMIFVNTKERADDLHSYLVSNGLKVAKIHGGIPPRER
                     KRIMNQVKKLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLSG
                     TAITLYQPSDDSDIRELEKMGITFEPKVYKDGEFQDTYDRDRRANREKAYQKLDTEMIG
                     LVKKKKKKIKPGYKKKIQWKVDEKRKRERRTANRAKGRAERKAKKQSF"
     CDS             complement(13347..14369)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_20"
                     /sec_met_domain="Glycos_transf_4 (E-value: 3.1e-41,
                     bitscore: 132.1, seeds: 116, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMSLIAGVAAFVLTVLAMPHFITYYKIKKIGGQQMHEDVKQHLA
                     KAGTPTMGGTVFLVVAILVSLIFNFHVFSEGHQTYGATVGILFVILIYGIIGFLDDFLK
                     IFRQINEGLKPWQKMALQIIAGLLFYFIHVLPSGTDSLAIGGLTIHLGVFYVLFVLFWI
                     VGFSNAVNLTDGIDGLASISVVISLIAYGIIAFVKGEFAILTIIITMIGALLGFFVFNH
                     KPAKVFMGDVGSLSLGAMLAVISIALRVEWTLLLIGVVYVFETASVMLQVSYFKYTKRK
                     YGEGRRIFRMTPFHHHLELGGLSGKGDKWSEWKVDAFLWAVGALASAITLWMVLGNVMK
                     "
ORIGIN
        1 acaactcaac cttaaaacca agaaatcctc cctaatgaca tcaatagcca taacgaatcg
       61 ctagcaattt tcgcaaatct gccattcgct cctcgataaa gggagacaag gttagctggt
      121 cttttctgac cacttcggat atttccagtg acatcctgct taagatatag ggagtggctg
      181 aacgagagtc tgcaagttcc gttcggtagg agtgcaggac ctgcttcaaa tcagcataat
      241 ctggcttatc tccaatagtt tcaattactt catcgatgat agctactgct tgttctcgtc
      301 tctctttgcc tcctgcaaac catttaagtc ctgtcattaa gaaaacctcc ttatttcttt
      361 taactaattt ttcaatcaca tctttagtat agcaccctga tagtcattta aaagccagcg
      421 tcccaaaaaa tagctatagg tcctaaatgg tagccaaatc cagattggat gctgactaga
      481 tagaggattt aaagctatat tcccaatgac tactcctaag attgctgata cgacacgtaa
      541 agaacgtaac acagcagaac taattttttg taatatcacc atggtaattc cttttctact
      601 agagtcattt acataaacta ctagagcgtt atctaaagaa tgattggcta ttattctgaa
      661 tctagcatgg ctaaagacac gaatctgtca ctttccatgc tgcttaaaac aaatacatca
      721 cttctcattt ctaaaaatca gctgactaag atcatcagag aacgataaag aaacataaag
      781 tgacaagata taaaataaaa atgttctttc ttgatgccag aaaaatgtta tcacacattg
      841 aatacagaca gccaagataa cttgtaggat aaatattatg tattttctag aaaaaacaga
      901 ttgttccaat agtaatcctc ctttcatgac atttttgaaa acccagacac tgtaagtttt
      961 gtctatacga tagaagaact tctttcaagc catagaaatc ctactctaat tttcacattt
     1021 ttcattaatc actttcttat tatagcgctt ttatgcactt tatgcaacgt aaattgaata
     1081 atgtcacaaa tggttactat attttctatc ttttaaaata ttttttgact tgcaagtaag
     1141 ctagaaaatc acagagaatt aacaaaagca ttaatacgac tagtactatg cggtctgtgg
     1201 tatcactgaa tgttagtaag gtgtaaaact ctacacaaag cactagaaat gagatgacca
     1261 gaaagacaat gaaggactgc catattatta acggatttac tgaatcggaa cgcttcttaa
     1321 gcatacagta gagcagccca tttacaaaaa tgactactaa agctagtgct ccgactgcta
     1381 accaaatctc tggagaagtc ttgcttttgt agagagaaat actggtactt ataaggaaaa
     1441 ctgccaatat agcagtagcg accctaaaaa atcgcaatac tctcggacta atattcttta
     1501 acttcatgat aaaacaatta agctatgaat aacctcagtc agtcttgtag actgaataag
     1561 ctattacatt taacgctatt cctttctgta ttttattcta ctgttgtaag atctcaagta
     1621 agtccttagc gattaaattc tactggagat gtaatacagt agtgtcatta gtacagatac
     1681 tttaaataag cgaatataca tatctttgtc ttttctatta caaagaaaaa caatcaaata
     1741 taatacaatc tccgctatca ttagcaagaa taattttact tcgggaacat caaaaataag
     1801 catttacaag gacctcacgt tcaaaggggc caaaagttac tttttaaact gtacccattt
     1861 tttaaaaaga agactataaa gaagcaaggt taggcctagc aaattaatgg tatgatggac
     1921 tgcatccaaa cttctaaata gattagcgag gcccattcct atgagaatgg tagccagtaa
     1981 atacggtttt gagtttttga acatactttt ctccttaaag tgtttttagc tttctgtgca
     2041 aagctattca cagactagca attgacaagg tatctcaatt agaatttctt tttagcggaa
     2101 ttggtaactt tgtgtttttc aagaaatgac ataataggct tatctaaaaa actcatcaca
     2161 gccatgaaag ccatccctaa aatataactt ttcaaatcaa acataatcca tcaccacctt
     2221 caacgtttgc aagtgcctcg agatcgagtg tttcaaaagt gttatttgtt tgccttatca
     2281 ttctaacaac ctcctaaact atttttagct ctttctttca agctatgatt ttattatagg
     2341 gtgataggcc acaaaaaagt agtgacataa atgtcactac ttttttccga tttcttttag
     2401 ctgatgtcag aaaaacaata tccataaata taatttttca gttgacacaa cttaccaatt
     2461 cctagatgat tactgacagg aatccaccta ttttttgagt cgctcccatt tactaaaaat
     2521 caaactataa gtgattaatg ccaaccctac caaattaatg atatgatgta caaaatctaa
     2581 atttctaaaa aggttagcaa tgccaaatcc taaaaggaaa atggctaata aatacatttt
     2641 tttatcttta agcatagggt cacctaaata ttagcagaat gtggcataac caactaaagc
     2701 tcctccccag taacctactg ggcctccagc tgatcctact agagcagatc cgattgtgcc
     2761 ggcataacac ttaacccatc cgccaccttc aacgtttgca agtgcctcga gatcgagtgt
     2821 ttcaaaattg ttcattgttt gtgttgtcat tctaacaacc tcctaaaata ttatttttta
     2881 gctttttctc tcaagctatg gttttattat aagttgtagg ccaacaaaaa agtagtgaca
     2941 taaatgtcac tactcgattt tgatttttaa gaaatctttt cgaatataaa atctatggtc
     3001 tagattagct tacgctcctt ccattgcacc tgcttgtagg ctgtacatct tatgataggt
     3061 accaccaagg gctaggagtt cctcgtggct accgtgttcg atgatgcggc ccttgtctaa
     3121 gacatagatg cagttggcat cttggatagt cgataggcgg tgggcaatgg caatggttgt
     3181 acgtccttga cgcatttttg ctagagagtt ttggacaata gcctctgtct ccgaatcaat
     3241 attggctgtc gcttcatcca aaatcaagat tttaggctga ctagcaacgg tcctagcaaa
     3301 ggctagaagc tgacgttgac cggttgaaaa acttgaacct cgttcggaaa ctggagcttc
     3361 ataaccttct ggaagtttgt cgataaagtg gttggcatcc acaaactcag cagcggcttt
     3421 gatttcttca tcagttaaat cttgatacat ggcaatattg gatttgattg taccatgata
     3481 gagaaagggt tcctgaagga caagaccaat gttcttacgt agctctgcct gactataatc
     3541 gcgaatatcc acaccgtcaa gaagaactcg tcctgattgg aactcataga aacgcataaa
     3601 gacattgata atagaggatt ttccggaacc tgtagaaccg acaaaggcga tggtttctcc
     3661 tttattgaca gagaaggaaa tactatctaa aatctggtgc ttgccatcat aggagaagga
     3721 gacattttca aagcgaatat tcccctcagt aaccttggca tctgtgcctc tctgctcagg
     3781 ttcataggtg cgctcgtcga tcaaggcgaa gacccgacct gctgagacca tcgaggtttg
     3841 caaggttgag aagttttgtg tcacttcaat caagggatca aagaggcggt taatgtactg
     3901 gataaaggca tacatggtcc ccgctgtgat gcccaaatag atacctcggt agccaaagta
     3961 ggccatgaga acagcatagc ccaggagctt cagtaaactc atggctgggc gtagaaagag
     4021 agaatccagt gacatggaac ggctggcgta aatcaggtgt tcctcattaa tggcatcaaa
     4081 ctcttttttg aggcgtttct cttggttaaa ggcctgaatg atgcgaatcc cttcgatact
     4141 ctctgacagt ttggcattta tatctgaaag caaggctctg gtcttttcaa tgatgaccac
     4201 tgattttttg cggtagagat taaccaaaag aacaatcaga ggaagaaaga gcacaataag
     4261 cccggtcaga cgaatgtcca agatcatcat ggtgtaaagg gtggtaacaa atataaagat
     4321 agccgaaata aagctagaca gaatccctga gaacatctca ctaatagtct ctgtatcatt
     4381 ggtcaagcgg gaaacgatag agcctgctgg agttttgtca aagtaagaca tgcctagttt
     4441 ctccatattg gcaaaggcat ctcggcgaat atccctgaca atgctgtagg acacacgcgc
     4501 aaaaaagaga tttcccaaat actgaactag tgtctgcaaa agataaagac catagtaacc
     4561 aatcagaatt aaacttgccg cctgattcat atcatgaaga tagtggtcaa taaaataaga
     4621 ggccacaagg ggaataatac tcttgataac cgttgtggac aagaggaagg ctaaagctag
     4681 aaaggtcaag aatttgtaag gcttgagata ggtcaagaga cgcttaaaca cagaccattg
     4741 gttttgatta ggcatcatct tcttctcctc cttccatttc taactgttga gactcatagg
     4801 tcttggcata ccaaccaccc tgagctagca aatcctcatg acggccacgt tcaatgatac
     4861 gaccatcctg catgactaag ataaggtcag cgtgcaccac cgcactcaga cgatgggcgg
     4921 taatgatagt tgtcttgtcc ttgcgggtat gtttgagatt gtcaataata gcatattctg
     4981 tcttggcatc aaccgcagat agggagtcgt ccaaaatcaa aatatctgga tccaaaatca
     5041 tggcccgact catggccaga cgttgttttt gaccgcctga taggctgaca cccttttcac
     5101 caatgattgt ttcaaagcct tcaggcatat ccttgatgtc atcataaact tgagctaact
     5161 tagtcgcttc ttctaccttg tcaaaggaga gatccggatt accaaagcag atattgtcta
     5221 aaatggagct ggcaaagaga aactggtctt gaggaacata gcccatcaag ctacgcaagt
     5281 ctgataggcg ataatctcgg atgttatgac cattcaaata gatggctcct tgattaacat
     5341 cgtgctcccg caagagcaac ttgacaaggg ccgtctttcc tgagccagtc tgtccaacca
     5401 aaccaagggt ttgccccttg tccaaggtga aatgaatatc tctcaaagta tcctcatcct
     5461 caaaggcaaa gcggtcaatc gcatattcta agcgaccatt ttcaatactt gggagagggt
     5521 gcgcaggatc ttgaacatct gattcctgct ccagaagatt ttcaatacgt tggtaggaca
     5581 catttcctct ctgtgtgata ttaaagagga agccaatggc cattagaggc caaaccagca
     5641 tgtccaaata ggtaatgaag gttaccaaat ttccgaccgt tatctgacca gcctgaatca
     5701 taaaggcacc gacaagaagg gtcaaaacat aggatgagcc aacaaagagt aagaccaaag
     5761 gatcaaaaag gctatcatac ttcatggtat gcatattctt tttaaaggtc atcttattgg
     5821 tctcttggaa ggactgaagc tcagcctcct gatagccaaa agacttggtt accttgatac
     5881 ctgataccga ctcttggacc ttattattaa gttctgaaaa ggctgcctgg gattctccaa
     5941 aagctttatg ggtcttgcgt cctaaacgac tagtcgcaaa agccatgaag gggaggggta
     6001 agacagccac cagtgtcatc tgccaggaaa tgctgaaaaa catggtgatt agggttacca
     6061 aggctgtgat agaggcatcc acggctgaca tgacgccccc gccagccaag cgggttaaag
     6121 agttgatatc attggttgca tgggccatga ggtccccagt tcggtacttt tgataaaaag
     6181 aaggcgacat cttagtaaaa tgctcaaaaa ggcgtgaacg cataatctgg cctaagcgat
     6241 aagaagtcgc caagatatac atgcgccaaa catagcgcaa atagtacatc cccagagctg
     6301 ccaaaagcaa atatacgaga ttcagaagca agatctgatt ggtcaatttt cccgatgtaa
     6361 tagcatcaat gacccgcccc ataaccatag gaggaatcag attgagtacc gaaaccagac
     6421 tcagtgccaa aatcccgaca atataccggc gtttttctaa cttgaaaaac caccaaagtt
     6481 ttgcaatgat tgattcttta aaaaacaagt gattccccct atccttacaa acgagtgatt
     6541 ataattctaa caaaaggtta tttccaatag cgataaattg taccatcttc taactgaaag
     6601 taaccaatat aagtcaattt cccaaaatca gtagactctg gcaattgata agcaaaggag
     6661 tcaaaattat agaccttgtg cccatcgtca atagagtagc tatccttatc gtggataact
     6721 gattcgtcct tcttggggtt ccaaatgcgt ctgatttcat cagatgtctt atactctctg
     6781 acaaaattga acaattcaaa gttagttgcc tcactgagat agcgaccatc ggtgttgtag
     6841 ttagctaatt gaggctctct cttaacctca gaatagttcc aaacctgccc tctttctcgc
     6901 ataatatcgg catcacgtcc gctttgataa gtatctgcct taaccatcgt cattgttgct
     6961 cctaacgtta atacggtaac tactgtcatc attaagtgtt tcattgtttc tccaaaagtg
     7021 tttattcatt tttccctctt ttgaatgtgt tgtatttgta tgatagaaaa taagtgaaac
     7081 ctgagacgcg tagggtccca ggtttttact ctttaaaatg cgtttgaatc agttttacaa
     7141 gaagacggta ggcagctaat gccaccaaac ctcccaaggt attggtccat aaatcatcta
     7201 actcaaagac acgattcgca tcaatgagga gatctagaat aacttgccca acctcaatcg
     7261 tcaaagacat gataaacgtg gctaaaagga ccttttgcca agacctaaat ctggggtaca
     7321 aggctaaaag tcctaaaatc agcggactca gcaagaaaat gttggtcaca ttttgcccaa
     7381 gcacaaagac aatctcttta agactatcca actgataaaa gttggtaaaa ctattaaatg
     7441 gggtcaatag aaccactaca cgaccaaaat gttgaatccc aggagtttca acaccttcaa
     7501 ctagtccata ctggggtgtc caacaaagga gtactaaaca aagaagataa gcacagacca
     7561 aaacttggct tagctttctt ccttttagtg tcagttctcc atccttatct acccaagtcg
     7621 tcagctgaaa catcttattt accttctgat ttaccagaag cttctgctac agccttttga
     7681 cggtcacgtt tcatagtgtt tgaacgcaat tgtccacaag cagcatcgat atctgtaccg
     7741 tgttcttgac gaacgacaca gttaaccccg tttttcttga gcacatcgta gaaggctgcc
     7801 acacgttcct tggttgaacg actatattgg tcgtgctctg atactgggtt gtaaggaatc
     7861 aagttgatgt atgacaactt acggattttc ttagtcaaat cagccaactc ttgagcgttt
     7921 tcaggatggt cattgacctc attaagcatg atgtactcaa aagttacacg acggttggtt
     7981 gtctggatgt aatactcgat tgcttcaaag agtttttcaa gtgggaacga gcggttaata
     8041 cgcatgatgc ttgaacgaag gtcattgtta ggcgcgtgaa gtgatacggc gaggttaact
     8101 tgaacacctt cgttagcaaa ttccttaatt tttggtgcca aaccagatgt tgacacggta
     8161 atgtgacgcg ctccaatagc aagaccattg tcattgttaa tggtacgcaa gaagcgaagc
     8221 acattgtcat agttatcaaa tggctcaccg atacccataa caaccacgtg gctgacacgt
     8281 tcaccgtcgc cacggtcatc aaaatatttt tgtaccaaca tgatttgtgc cacaatctca
     8341 ccagcagtca agtcacgttg tttcttaatc aaaccactgg cacagaaagt acaaccgatg
     8401 ttacatccaa cctgagttgt cacacagaca gacaaaccat agtgttggcg catcaaaacc
     8461 gtctcaatca acataccatc cggcaattca aaaagatact taacggtacc atctttagat
     8521 tcttgaacga tacgttgttt caatgggttt acacagaaat tctcattcaa tttagcaata
     8581 aaatcctttg aaatgttggt catttcttcg aaagactgca cacgcttctt gtagagccaa
     8641 tcccaaattt gagtcgcacg gaatttcttt tcaccgtgtt ccatagccca gtcgatcaac
     8701 tcatcacgag taagaccata aatagaaggt ttgtagcctt ccatatcctc taacttctga
     8761 cgtttacggc gttctggttt tgcttgtgtt gttacttctg acatagttta atttcctttt
     8821 tttctgattg taaaatgctg accatctgac ttggtctggc tttgtttctt cgatggggtg
     8881 ttttgacctt tagattttgg agcttgcttc tgactcttct tgaagttaga cttacgctca
     8941 cggccaccgt cctcggatct agatttaaac ttaggacgac gcttgatttt ctcaaagttt
     9001 gggccctctt gatccctatc tcttcgtttg gacttgtctg gcttttgctt agcagaagct
     9061 ttttgcccct tattcttttg agaagcattg cgctctctat ctctagattc ctgagaagca
     9121 ttacgacgat tattagaacg acggcgcttg cgacgaggct ctgtctcctc ttcaaagacg
     9181 attaactgcg gctcttcatt tttcaaaata aagtaagcac agccaaaggc acagtattca
     9241 cgcaaatact ccgataatcg gctaatgcgg tctgtcttac gcgtattagg gcgctcgtcc
     9301 tcgtaaaatc ccttaagacg aagctgatca ttagaccagt ccccaacgat ataatcatac
     9361 ttgagcatga tttcagaaaa acgttgccca aagcgggtag cgtctaaagc atccttgtga
     9421 ttttcaagaa ctgtaaactg acaggcatct gatttcagaa gatcagccac atacacaaag
     9481 tctggccctg gatatttatt ataattaaac atttctggca agatttcttt acgcatgtgc
     9541 catcctttct gctctctctt attttctatc ctgatgctgt aataatgtct ctatatctta
     9601 tcccaattgg caccattttt tcctaaatac ttggccacaa gttcccttaa caaatctgga
     9661 aaaagaagag taacctcctt ttccttaatt gtagggaagt aagaagcaaa gtagtactgg
     9721 tccacaagga ccaaactaaa cttctcattg gaatctacaa cccttctatt atacaacaaa
     9781 ttaccgtttt tgtaagcaaa attccctgtg attacttcac caaatgtctt ccctctgaat
     9841 cccatacctt taatagcttg atttttaagg agttcagcct tagtaaaaac ttcctgacag
     9901 atttctttga gttcttgtcc tgtcacgact agacgtgcca tccgcatctg gtgaggaagg
     9961 gcttcttgca ggtctgccat ggtcacttga ggacctagtg ttttcatgat aagtccagta
    10021 tttaaaagcg ttaattggct atcggtctcc tgacaaacag cctgtaaaac caattgacag
    10081 gtctcatcaa aatctagttc tcgacctaga ttagctactt ttttctgagc taaacgacga
    10141 tggccttcct cacgcatagc cttgataaag gtttcgtcct ccttgtctaa atccaagatg
    10201 taggacttgg tggggatagc ctcaatctga cattctatca atcgcccatt ttccacagta
    10261 aggtcaatac agccaagata atagccatat ctgtcagcag ctgccaaata ggtttcattg
    10321 actaatttcc cctcttcaaa aaggtgatgc gtgtggctcc cgatgacaag gtttacctgc
    10381 ggataagtct ctgcaatctg ctcatcatag cgtacaccca gatggctaag aacgacgact
    10441 atgtctgcat cctttacctc aggacgagcc aaatcctctt ccaacctagc cataggctct
    10501 aacacctgcc aaccattggg agcataggtg atgtaatatg ggaaggtata ggctaagaaa
    10561 gcaatgtttg tacctgcttt agttctgtgg ataagatagg acttggccca ttcaggctgt
    10621 ctcccctcat ccttgagatt tcctatgata ggctgaaact tagcctgctc ataaagacag
    10681 tctagctcat ccttggccag accaatcccc tcattatttc caatagtcgc atagtctatc
    10741 cccaactcat tcatcagggc tacattaaaa cgcccggctg tcgcatcaga taagggatgg
    10801 gacttatcca cattgtcccc aagatctacc ttaatcaact ctctatccgt ctgactcaaa
    10861 tcatccacag ctcgcttgag ttgtggatac tgttcaaaat gagagtgtaa atcattgata
    10921 tgaagaattc gaatcgtgtc tttcatgact cctattgtag cacttttgct ataaaaaaac
    10981 ttgacaatca ttctgccaag tttttacatg ctatttttca aacaggaacg tattcctagt
    11041 taactttctt tttaacatat tcttctgcga gatgatagac gtcatctgct agggatatac
    11101 tgacatagat gcacacaatt gagaaaattt ctcctctaaa gtgttgccaa gcaaagaata
    11161 taagcccata aattaggaga gcaagtacta tttggccaaa aaattgactc agtaatcgcc
    11221 taataacgac aaataagtcc ataagtaatc ccatctttaa taccataacc aatacccttt
    11281 aaggctgcac cttgccaagt acctgtttga ataccacctt taatggctcc tccaacagcc
    11341 ccgacgccta cggcagctgt agctccccaa aaactacatg ctccaccctt aacagtagaa
    11401 agatcttcgg aattaagtga gttaaaattg ttaatgattt gtgtcgtcat taaaacaacc
    11461 tcctttaaaa tattttttag ccttttctca aaagctatga ttgtattata gatagaaagc
    11521 caacaaaaaa gtagtgacat aaatgtcact acctgatttt gagagttgac tcaactaata
    11581 acctcaaact tacacattat tttactttaa acggaaagct tcttaaaaat gtctgtgata
    11641 aaactattta aaatctgtca tagtttcagt tcttaagaca gccaattatt ttgcgagtgt
    11701 agtgagcata tactgagact tgtcgctgtg ataatgacga ctaagacttt gtagtcataa
    11761 gcgttgggaa gttttgagac cttaggctca aaagaaaaat atatcttcaa actaaataag
    11821 gtcttttgag tttccaaaaa gtttgataat aatcaaaaaa gctgaaacac tttggtttca
    11881 acctcttgaa tttttaaatt aaaatttgct ctcacctaga agccaatact tagaaacttt
    11941 gcttcttagc tttacgctca gctcgcccct tagcacggtt agctgtacga cgctcacgtt
    12001 tgcgtttttc gtcaactttc cactgaattt tcttcttgta gccaggcttg atttttttct
    12061 ttttcttctt aaccaaacca atcatttccg tatcaagttt ttgataggct ttttcacgat
    12121 tggcacgacg gtcgcggtca taggtatctt gaaactcgcc gtccttatag actttaggtt
    12181 caaaggtaat ccccatcttt tcaagctcac gaatatctga gtcgtcgctt ggttgataga
    12241 gggtgatggc tgttcctgac aagccattac gtccagtacg tcctacacgg tgaacaaaga
    12301 aggacaagtc ttgagggatg gcatcattga ttacatggct aaccccttca atgtcaatcc
    12361 cacgcgccgc aaggtccgtc gctacaatgt actcaaaatc aagcttcttg acttgattca
    12421 tgatacgctt acgttcacgt ggtggaatac cgccgtgaat tttcgctact ttaagaccat
    12481 ttgacactag gtaactgtgc aaatcatcag cacgttcctt ggtattaacg aaaatcattg
    12541 ctagatacgg ctgcatcccc ttaagcatct caagaatctg ctcattcttg ttgcgaccct
    12601 tggtagatac caaccagtta tcaatagtat ccgcaataac tgttgaagtt ttgatttgtt
    12661 ccatgactgg attggtcaaa tacttcttca agaatggttg caatttttga ggaatggttg
    12721 ctgagaagac caaaatttga acttccttag gcagacttgc cgcaatcttg tctacagtat
    12781 ctaagaatcc catatccatg gtcatatcag cttcgtcaac aacaaaggta tgggccttgt
    12841 gaatagccag gtcaccagac ttaaccaggt cataaatacg ccctggtgtc ccgataacaa
    12901 tatgaggttg tgctaccttt agtttctcaa tctgacgttg cttgtctgta ccacccacat
    12961 agttgaccac acgaatttca gtctcagagt gtttggcaat ttgttttgtc gcttggtaaa
    13021 tttgtgtcgc caattcacgt gatggtgctg taataacaac ctgaacatcg ccactctttg
    13081 gattcagttt ctcaaaaatt ggcaagagga aggtatgtgt tttccctgaa cccgtctttg
    13141 attcacccac taaatcacga cctgaacgaa ccactggaat caacttctgt tgaacaggtg
    13201 ttggctcctt aaacttaatc tcgtcaagag cctcctgaat aaatgtttta aaattaaaat
    13261 ctttaaatga catgtttatt tacttctttt ctatctagtc tatccctatc attataacaa
    13321 aaaaagagca tttctgctcc tttcatttat ttcataacgt ttccaagaac catccaaagg
    13381 gtaatggcac ttgcaagcgc tccaactgcc caaaggaaag catcaacctt ccactctgac
    13441 catttgtctc ccttacctga aagaccaccc aattcaaggt gatggtggaa tggtgtcata
    13501 cggaaaatac gacgaccttc accatactta cgcttagtgt atttgaaata gctgacctgt
    13561 agcatgacag aagctgtctc aaagacataa accacaccaa tcaagagtag ggtccactct
    13621 acacgtaagg caatagagat aactgcaagc atagctccga gtgacaagga accaacatct
    13681 cccataaaga ccttggctgg cttgtggtta aagacgaaga agccaagaag agcaccaatc
    13741 atagtgataa tgatggtcaa gatagcgaac tcacccttga caaaagcgat aattccatag
    13801 gcaatcaagc tgataaccac agagatagaa gctaaaccat caataccgtc tgtcaagttc
    13861 acagcatttg agaaaccaac aatccagaat aaaacaaata gaacataaaa gacaccgaga
    13921 tgaatggtta atccaccaat agctaggcta tctgtcccac tagggagtac gtggataaag
    13981 tagaaaagca aacccgcaat aatctgcaag gccatctttt gccaaggttt aagtccctca
    14041 ttgatttgac gaaaaatctt aaggaaatca tcaaggaagc cgataattcc ataaatcaaa
    14101 attacaaaga gaatccctac tgtagcacca taggtttggt ggccctcgct aaagacgtgg
    14161 aagttaaaaa tcaagctaac caagatggca accactagga agactgtccc tcccatagtt
    14221 ggcgtcccag ccttagccaa atgctgcttc acatcttcat gcatttgttg gccaccgatt
    14281 ttcttgattt tgtagtaagt aataaagtga ggcatggcga gcaccgtcaa cacaaaggcg
    14341 gccacgcctg ctatcagact catagtcatc ttagtctcct aaagtaatgg taatcttctt
    14401 ggttttagac agggcttttc ctgccgcaac actttgtttg gtaacagtcc ctgacttgcc
    14461 acccttgtaa gtaattttaa tgcccttcca tttggcaaag gtttcaacgt tcttcttggt
    14521 ccaaccatac atgtctggaa gttctgtgaa atcattggtc atgataagaa tctgttcatt
    14581 agccttgata ttggctttgg catctacaga aaccttctca atcttatcac caacacccag
    14641 aacaatcgga tgaatcaagt tttgacgaag ggtgttagct gtctcgcccg gactcttacc
    14701 gataatatcg ccggtttgat agctcgtttc ctcggtcttt tcactacctt cagacacaga
    14761 agtatctagg gtgtctccca tagacatggc ttcttccaaa accgggttaa ccacagttgc
    14821 ataaaaatta ttatcccaag tcttaggctc cagtacagtc acatacatga tgtattctgg
    14881 attatcttta ggtaccatgg ctacaactga gttgagagtc tcgtttgtcc caactttata
    14941 ggttcctgtc ttttcatcgg gcacttgggc tgttcctgac ttaaccgcaa catcattgtt
    15001 accaacctga atgattggtg aaccttcaga cttgttgtac agggtaccaa actctggatc
    15061 tgtaccaaca gaaatcatat aattacgggt ttcagaagca gcctgcttag agacaggttt
    15121 gccaataact tctttcttgg ctgtacgaac agtaccttta ttagtatcag caacttgttt
    15181 tataaattga ggctctaaca taataccatt gttagagatt gcggtaaagg ctcgaagcat
    15241 ttggacttga gttactgaaa tcccttgtcc aaaagatgat tgggcaatat taactgagtt
    15301 tcgagagaca atccctgaag actcgccaac catcccaaag cgggttggaa ttccaaattt
    15361 gtatagcgat aggtagttag accagacttt gtctcccatg gcttgttcca gcatggtcat
    15421 accaacgtta cttgaatatg aaaaaccttg tgcaaatgac atcgttcgac ctgttgagat
    15481 accttcattg attgaccagt cattgatttc aacatcacca accttaatac cattagcgtt
    15541 actgaaggtt gcattcgggt tgaaacttcc attgttaata gcagctgaca agagcatgac
    15601 cttcatggtt gatccaggct catactgagc ttcgtaaaga cggttaaccc agtcatagtt
    15661 tttcttagcc tgtccctcaa gagtatccga attataggtc ggacgttgtg tcgttgcaag
    15721 aatctcacct gtcttagcat taacaactgt cgctgaagca ttgacacctt gcgtctgctc
    15781 cataaaggta tccatctgcg tttctaagaa ggtttggaga ggcgctgaca aggttgtata
    15841 gatgttctta ccatcgatag cttccttggt aatggtttcc gtacctagaa gcgtattacc
    15901 gtttttatcc ttctcataga tggcctcacc atctgttcca gtcaagaggc tattgagcga
    15961 acgctccaaa ccagtttgac caatcaaaga atatgagccg tcttttttat tttcaacagc
    16021 ttcggcacga ccaagaaact ctgacgcgaa ggttccatta ggatacattc gtgacgttgt
    16081 tgcttcaaag gccatcccct taattcccgc atctttaaag gctttttcta gttcttcttt
    16141 aacagagtag gtaattccct tcccctttag tccaaaggaa acctggtagg cacccttagt
    16201 acgcaattgg gccaaggaat cactcttttc aattcctagc ttatccttta gaatatcagc
    16261 aaccttgtca aactgactat cttggacata gagtttttct tgagtcgctg acacatagct
    16321 agtcgacacg attgcgtaaa tggcataact ggttgaatct tcagccaaaa catttccatt
    16381 tcggtcgtaa atcgtcccac gcttggcagc cactgtggtc ttagtgttat aagatttagc
    16441 agcctgggtc gacaaatcaa caccaaactt actgtctgcc ccgataatca ccacaaagtt
    16501 gataataaag acgaaaaaga taaagatgct gagaaccata
//
