LOCUS       c00036_JAHLXJ0..       13280 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHLXJ010000006.1 Streptococcus thermophilus strain 159
            NODE_6_length_100972_cov_113.484575, whole genome shotgun sequence.
ACCESSION   JAHLXJ010000006
VERSION     JAHLXJ010000006
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:12:34
            Original ID  :: JAHLXJ010000006.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 87692
            Orig. end    :: 100972
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13280
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[92692:100741]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..13049
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..13280
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13280
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             89..1348
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 319.6; E-value:
                     6.6e-97)"
                     /gene_kind="transport"
                     /locus_tag="ctg36_89"
                     /transl_table=11
                     /translation="MAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQESVSGI
                     KVTKSFGYQEAELQSFQETNKMTFEKNMHTMKYDSLFDPLVLLFVGSSYVLTLLVGAFM
                     IQAGQITVGNLVTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIETLLEQESDVQDPA
                     YPLPSIENGRLDFAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGPTGSGKTALVKLLLRE
                     HDVNQGAIYLNGHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNIRFGNPDFSIDKVEE
                     ATKLAQVYDDIKDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILDDSLSAV
                     DAKTEHAIIDNLKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHDDLLAQGG
                     WYAKTYESQQLEMEGGEAHA"
     CDS             1341..3086
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     289; E-value: 4.3e-88)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 314.8; E-value: 2e-95)"
                     /gene_kind="transport"
                     /locus_tag="ctg36_90"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGTLSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVAIIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRL
                     KKEFDAINEEHLIYAIRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNI
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLI
                     DGVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     TMEGE"
     CDS             4100..4909
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg36_91"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.9e-46, bitscore:
                     148.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMRPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMM
                     TFARDYLLTILSQRLTIDVILSYIRHIFELPMSFFCHKTYRGGYLTF"
     CDS             5001..6254
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 262.4; E-value:
                     1.5e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_92"
                     /sec_met_domain="TIGR01193 (E-value: 5.6e-193, bitscore:
                     635.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSNAMVNS
                     AIIEDINGIETIKSLTSEEVCYQKIDGEFVDYLDNSFRLSKLSILQTSLKQGAQLILNV
                     LILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYL
                     IESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVGVSGSG
                     KTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLENLTLG
                     AARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSP
                     VLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGRVVETG
                     SHQDLMSYPGFYYQLFRK"
     CDS             6270..7637
                     /locus_tag="ctg36_93"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEGLQK
                     QLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKTNTE
                     VNNQAAIASNTGSAIDNQISQLQTRVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQ
                     YATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQF
                     LQNAGQQLSSVETQINDTESKINQADVLLTNTLIQSPEDGILHLSQADKKATMAATGTE
                     LAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSA
                     TETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ"
     CDS             7652..7813
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_94"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.7e-08,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQA"
     CDS             complement(7831..9171)
                     /locus_tag="ctg36_95"
                     /transl_table=11
                     /translation="MLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLAF
                     NFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLITF
                     FIFPFFNISITDYQSSLLISIPSSIAPLCLSFLFIKLFKGSFTILQKQKSNSPIQHIII
                     VANFFMFGYTLLLQILMYLENTTHSSTLELRKLCVVISLVLFFIMIVFLDRNIREMIQG
                     QLDFQKNLQLENLYTYNKHIEGLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEAYDS
                     VLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGME
                     TLDFIIVTSIFLDNAIEGAIQTQNPKITISFWEDHCSQLLSISNTISEEKTETKTIFER
                     GVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     CDS             complement(9165..9902)
                     /locus_tag="ctg36_96"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEEAVAHELKSFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIIRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGETIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNLTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGRGC"
     CDS             10157..10333
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_97"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.5e-11,
                     bitscore: 37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGLSCDEGMLAVGGLGAVGGPWGA
                     VGGVLVGAALYCF"
     CDS             10352..10552
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_98"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1e-08, bitscore:
                     28.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNKQLERFKKLDTNALSNVSGQGYGAQCVIGTTGMTIVGAAFFG
                     IAGAGAGFAGGSTAFCYDTAK"
     CDS             10578..10733
                     /locus_tag="ctg36_99"
                     /transl_table=11
                     /translation="MKKYLIIFSTIAMIYLYSKVLLSSGNIYQLLLASIGFFFFLFGVY
                     RQYRKN"
     CDS             10908..11138
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_100"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 9.8e-19,
                     bitscore: 60.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGVCSWGGFAKQGVATGVGNGLRL
                     GIKTRTWQGAVAGAAGGAIVGGVGYGATCWW"
     CDS             11334..11549
                     /locus_tag="ctg36_101"
                     /transl_table=11
                     /translation="MIENFDIREELFVIMTKKRLVSLMMSMGFVLVALHNFGEKLNFGL
                     QCLNLIGLCLFLFLMCTVIKDIRSDK"
     CDS             11646..11813
                     /locus_tag="ctg36_102"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIVMGLANLFRSLDAVHHTINLLGLTVLLYSL
                     LFKKWVQFQK"
     CDS             12143..12544
                     /locus_tag="ctg36_103"
                     /transl_table=11
                     /translation="MKLKNISSSVLRSFRTITAALAVFLISISLSLYKSKISPGTWLTV
                     GALAFVVIFVNGLLYRMLKKRPDSVNLLTIRQSFIVFPVITFLVLSVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLSYLQVKKYFKQ"
     CDS             12795..13049
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_104"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.1e-14,
                     bitscore: 46.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENLNTLDLETLASVEGGGCSWGGAGGATVQGAIGGAIGG
                     AFGGNVVLPVVGSVPGYLAGGVLGGAGGTVAYGATCWWS"
ORIGIN
        1 ggggtgtcat gtcagccgtg gatgcgtcta tcacagcctt ggtgacttta atcaccatgt
       61 tcttcagcat ttcctggcag atgacctgat ggcagtctta cctctacctt tcatggcttt
      121 tgcgactagt cgtttgggac gtaagaccca caaagctttt ggagaatccc aggcagcttt
      181 ttctgaactt aataataagg tacaagaatc ggtgtcaggt atcaaggtaa ccaagtcttt
      241 tggctatcag gaggctgagc tccagtcctt ccaagagacc aataagatga cttttgaaaa
      301 gaatatgcat accatgaagt atgacagcct ttttgatcct ttggtcttgc tctttgttgg
      361 ctcatcttat gttttgaccc tccttgtcgg ggcctttatg attcaggccg gtcagataac
      421 ggtcggaaat ttggtaacct ttattaccta tttggacatg ctggtttggc ccctaatggc
      481 cattggcttc ctctttaata tcacgcagag gggaaatgtg tcctaccaac gtatcgagac
      541 tcttttagag caggaatcag atgttcaaga tcccgcttat cctcttccaa gcattgaaaa
      601 tggtcgttta gactttgcga ttgaccgctt tgcttttgag gatgaggata ctttgcgaga
      661 tattcatttc accttggaca aggggcaaac ccttggtttg gttggaccga ctggctcagg
      721 aaagacggct cttgtcaagt tgctcttgcg ggagcacgat gtcaatcaag gagccatcta
      781 tttgaatgga catgacatcc gagactatcg cctatcagac ttgcgtagct tgattggtta
      841 tgttcctcaa gaccagtttc tctttgccag ttctatttta gacaatatcc gctttggtaa
      901 tccagatttc tccattgata aggtggaaga agcgactaag ttagctcaag tttatgatga
      961 tatcaaggat atgcctgaag gctttgaaac aatcattggt gaaaagggtg tcagcctatc
     1021 aggtggtcaa aaacaacgtc tggctatgag ccgggccatg attttgaatc cagaaatttt
     1081 gattttggat gactccttat ctgcggttga tgctaagaca gaacatgcca ttattgataa
     1141 tcttaagcat actcgcaagg acaaaacaac tattattacc gcccaccgtc tcagtgcggt
     1201 ggtgcacgct gacctcatcc tggtcatgca agatggtcgt atcattgaac gtgggcgtca
     1261 tgacgactta ctagctcaag gtggttggta tgccaagacc tatgagtctc aacagttaga
     1321 aatggaagga ggagaagctc atgcctaatc aaaaccaatg gtctgtgttt aagcgtctct
     1381 tgacctatct caagccttac aagttcttga cctttctagc tttgaccttc ctcttgtcca
     1441 caacggttat caagagtatc attcccttgg tggcctctta ttttattgat cactatcttc
     1501 atgatatgaa tcaggcggca agtatgattc tgattggcta ctatggtctc tacctcttgc
     1561 agacactagt ccagtatctg ggaaatctct tctttgcgcg tgtgtcctat agcattgtca
     1621 gagatattcg tcgagatgcc tttgccaata tggaaaaact gggtatgtct tactttgaca
     1681 agaccccagc aggttccatc gtttcccgct tgaccaatga tactgagacc attagcgaga
     1741 tgttctcagg aactctgtct agttttattt cggctatctt tatctttgtt accacccttt
     1801 acaccatgat gatcttggac attcgtctga ccgggcttat tgtcctcttt cttcctctga
     1861 ttgtcctttt ggttaacctt tatcgcaaaa aatcagtggc catcattgaa aagaccagag
     1921 ccttgctttc agatataaat gccaaactgt cagagagtat cgaagggatt cacatcattc
     1981 aggcctttaa ccaggagaag cgtcttaaaa aagagtttga tgccattaat gaggaacacc
     2041 tgatttatgc catccgttct atatcactgg attctctctt tctacgccca gccatgagtc
     2101 tactgaagct cctggcttat gctgttctca tggcctattt tggctaccga ggtatctatc
     2161 tgggtatcac agcaggtacc atgtatgcct ttatccagta tattaatcgc ctctttgatc
     2221 ccttgattga agtgacacaa aacttctcga ctctacaaac ctctatggtc tcagcaggtc
     2281 gggtctttgc cttgattgac gagcgtacct atgagcctga acagagagac acagctgcca
     2341 aggttactga ggggaatatt cgctttgaga atgtctcctt ctcctatgat ggcaagcacc
     2401 agattttgga taatatttcc ttctctgtca ataaaggtga aaccatcgcc tttgtgggat
     2461 ctacaggctc tggaaaatcc tctattatca acgtgctcat gcgattctat gaattccaat
     2521 caggacgagt tctcatagac ggtgtggata ttcgtgatta tagtcaggca gagctgcgca
     2581 agaatattgg tcttgtcctt caggacccct tcctctatca tggcacaatc aaatccaata
     2641 ttgccatgta tcaagattta actgatgaag agattaaagc tgctgctgag tttgtcgatg
     2701 ccaatcactt tattgataaa cttcctgaag gctatgattc cccagtttcc gaacgtggtt
     2761 caagtttctc aaccggtcaa cgccagcttc tagcctttgc tagaaccgtt gctagccagc
     2821 ctaaaatctt gattttggat gaagcgacag ccaatattga ttcggagaca gaggctattg
     2881 ttcaaaactc tcttgcaaaa atgcgtcaag gccgtacaac cattgccatt gcccaccgcc
     2941 tatcaacaat ccaagatgct aactgcatct atgtcttaga caagggccgc atcattgaac
     3001 acggtagcca cgaagagctc ctagccctcg gcggcaccta tcacaagatg tacagcctac
     3061 aagcaggcac catggaagga gagtaagcta atctagacca tagcttctat attcgaaaag
     3121 atttcttaaa aatcaaaatc gagtagtgac atttatgtca ctactttttt gttggctacc
     3181 accctataat aaaatcatag cttgagagaa aaagctaaaa ataatttagg aggttgttag
     3241 aatgacaagg caaacaaata atacatttga aacactcgat ctcgaggtac ttgcaaacgt
     3301 tgaggtagtg taaaataagt tgtgtaaaca caaaaaggaa taaatccgtt atagtagagt
     3361 tgcaaaacat tactagaaag agatttattc ctatgactca gtttaccaca gaactactta
     3421 acttcggctc tataatttct gtagtgggaa aaaccactgt agagattata gagctttttg
     3481 agatggtgcc acctcaaggt tgagtaaatc aaaagataga aggcacaatt actcaaggtg
     3541 gaaataaggt gggcattaag gaagggaacc cctctagtga cgctaaaaat agcattgaca
     3601 gtgataacaa atacacttac aaagctaagg aaaattaaac cgataattga gtaatcgaat
     3661 ctcaagaggc tgatttagcc ttttttgata ggattttttg agatatggat tgacgttttt
     3721 cataatgtta tcccttttcg gaataaaaat aatcaaatta tgacatcata cgatagagat
     3781 aggctccgag gctatcagca gtcatggttt cctttggaaa taccagggct ggcacagtaa
     3841 taatggttag atcaaatacg tatgcttgta ggactatttt agaatgtttc cttctaataa
     3901 ctattgtata actttgaaat cgatttcaat gaacttgtcc taaatgaccc caaatacggc
     3961 ttaaatggta atagtggaga tgactttaag atttttctta ccgtttggga cgtatggcaa
     4021 ctttttggga cgctggctct ttttatcctg aaaatatgac atactaatca tatgataatt
     4081 tgtgatgaaa gggtttggta tgtttcgttt tcgtaggact tttgtccctc aaatagacat
     4141 gagggattgt ggagttgctg ccttggcatc agtggccaag tactatggtt cagattattc
     4201 attagcacat ctgcgtgagt tggcgaagac caataaagaa gggacaactg ccttaggtct
     4261 tgtagaggct gctaaaaaaa ttggctttga aacgagagct ataaaggctg aaatgtcgct
     4321 ctttgagatg gaagatgttc cttatccttt tattgctcat gttaataaag atgggaagct
     4381 tcaacattat tatgttattt ataaaagcac caaggattat ctgataattg gagaccctga
     4441 tccaagtgta aaagtaacta aaatgactaa agagcgtttt gagaaagagt ggacaggtgt
     4501 tactcttttt atgagaccgg aacccagtta taaaccacat aaggataaga aaaatggact
     4561 ctgggacttt ctccctttga tctttaaaca aaggtccttg atagctaata ttgtctttgc
     4621 cagtctcttg gttactttaa taaatatttt aggttcctat tatttacaag gtattctaga
     4681 cgaatatgtc cctaatcaaa tgaagtctac cttaggaatt atctcaattg gattagttgt
     4741 gacctatgtt ttacaacaaa tgatgacttt tgcaagagat tatctcttaa ccatactgag
     4801 tcagcgattg accattgacg ttatcttgtc ctacatacga catatctttg aactcccaat
     4861 gtcttttttt tgccacaaga cgtacagggg aggttatctc acgttttagt gatgctaact
     4921 ctattatcga tgctctggct tcgacgatat tatcactttt ccttgatttc tctattgtga
     4981 ttatcgtacg aggcgtgtta ttgatacaaa atagcaatct cttcaagcta gttctttgtt
     5041 cggttccaat ttataccctt atcgtctttg cctttatgaa accttttgag cgaatgaatc
     5101 atgacgtcat gcagagtaat gctatggtta attcagccat cattgaggac attaatggga
     5161 ttgaaaccat aaagtcacta accagcgaag aagtatgcta tcaaaagatt gatggtgagt
     5221 ttgttgacta tctagacaat tcttttcgcc tttctaagtt atctatacta caaacatcat
     5281 tgaaacaagg tgctcaactt attttaaatg tacttatcct ctggacaggt gctcagttgg
     5341 tgatgggaaa taccatttcg ataggacaat tgattacttt taatatgttg ctttcctact
     5401 tcacgaatcc tttggaaaat atcattaacc tgcaaaccaa gttacagtct gctaaggtag
     5461 ctaatactag gctcaatgag gtctatctga ttgaatcaga gtttggacaa agtgatgata
     5521 cctatcaaga aggcattgcg gatggagata tcactgttac ggatttatct tataaatatg
     5581 gttttggtcg tgatactttg actgatgtca gtttgacgat tagacaagga gaaaaaatca
     5641 gttttgttgg tgtcagtgga tctggtaaga ctactctagc taaaatgttg gtcaattttt
     5701 atcaaccata taaggggcac atagatttta atggtcaaaa tattagtcgc atagacaaga
     5761 aaactcttcg tcaacatatt aactatctcc ctcagcaatc ctatatattt agtggtagtg
     5821 ttttagaaaa tcttacttta ggtgcagcac ggggtattac gcaagctgat attttgaaag
     5881 cttgtgaaat agcagaaatt cgtcaagata ttgaaaacat gcctatgggg tttcagacag
     5941 agctgtctga tggagcaggt ctgtctggag ggcaaaagca acgtatcgct ttggcgcgtg
     6001 cactactaac gaaatctcct gtactaatct tagatgaagc aactagcgga ttggatgttt
     6061 tgacagaaaa gcaggttatt gataacctcc tagcactaaa agataaaacg atcatctttg
     6121 tagcacacag gcttagtatc gctgagcgga ccgaccgtat cgtagtcatt gatcacggac
     6181 gcgtagtgga gacaggttct catcaagacc taatgtctta tccaggtttc tattatcaat
     6241 tatttagaaa gtgaggaaaa ggaaacacga tgaatccaca gttgtttaaa agcacagagt
     6301 tttaccatcg tcgctaccac aatatgtcta ctgttttgat tactcccttg attttgttag
     6361 ttattttcct ttttcttttc gctttttttg ctaagaagga agttacagtc acgtctagag
     6421 gaagtataga gccaaccaag gttatcgcag taatccaatc aaccagtgac aataccatca
     6481 tagataatca actggttgct aataaggttg ttaaaaaagg ggacacctta gttcagtatt
     6541 cagagaccat ggaggcatcg caaaaagagg ggcttcaaaa gcaactagaa cttttaaaaa
     6601 gacaggaatc aggtttgaag accttgcaat ctagcctaac gcagggaacc aatcttttcc
     6661 aagaacagga agacgagttt ggttatcaga gtacttttaa cacctaccta agtcaggcac
     6721 aggatattga cttgggtgtg gctaaaacaa atacagaggt taataaccaa gcagcaattg
     6781 cgagtaatac cggttctgct attgataacc agattagtca attgcagact cgggtctcag
     6841 agtatgaggc gctctctcaa gctattacca atcatgaaac gactttacct gaaggcaatc
     6901 ctcatcaggc aaccttaaat gcctataaca gtcagtatgc tacgacaccg gatgccagtg
     6961 taacagacca atacctatct caagttaata ccaatatttc gagcttgaat gcttccatag
     7021 gtaatctaga aatccaaaag gctgggacag gcacagttgt aacttatgac aatagtgata
     7081 gcactaaaaa agaagctcta aaaaatcaat tcttgcaaaa tgcaggacag caattgagct
     7141 cagtggaaac acaaattaac gataccgaga gtaaaatcaa tcaggcagat gtccttctga
     7201 ctaataccct catccagtca ccagaagatg gaatcttaca cttgagtcaa gctgataaaa
     7261 aagcaaccat ggctgcgaca ggaactgagt tggcccagct ttatcccgat atgactcaaa
     7321 cccaggaagt tgccattact tattatgtga attcggatta tgtgccaaaa ctgcaaaaag
     7381 gccagtcagt tcgactgacc ttggataagg ttggtaatca cggtaccaca attattggaa
     7441 aacttgagag tattgataat tctgccacgg aaacagaaag ggggaatgtg tttagagtaa
     7501 ctgctagggc aagtatttca gaaaaagaag cccaaaatct acgttacggt ctagaaggtc
     7561 gtgtgacaag cgttattgac caaaagacct acttcaatta ctttaaagac aagttactaa
     7621 acttgcaaga ccaataggag gagaattact gatggctaac aatacgatta ataactttga
     7681 aacacttgat aaccacgctc ttgaacaagt cgtaggtgga agtgggtgga tggattatat
     7741 aaatggtttc ctaaaaggat tcggagggca aagaacgctt ccaacaaaag actataacat
     7801 tcctcaagct taggtataga aaaaaggctg ttaggccttt ttagttattg ttaattgttg
     7861 tgtgaatgag aaattgttac tctgtgtttc taagtttaca ttgatatagt tatctaagat
     7921 ttctgtgaca ttagcaaggc caatgcctcg ctctcgtccc ttgttggaga cacctctttc
     7981 aaatatggtt ttggtttctg ttttttcttc acttatggta ttgctaatag ataatagctg
     8041 tgaacaatga tcttcccaaa agctaatagt aattttaggg ttttgagttt gaatggcacc
     8101 ttcaatagcg ttatctaaaa aaatagaagt gacgataatg aagtccagag tctccatccc
     8161 aatcaagtgg atgggttctg ggatgctaat ctgagcttca atgccttctt cttctgcttg
     8221 tagaactttt gcggacagaa ggcttttcaa agtgttatcc tgaatattaa cgagtctagc
     8281 taagtcaaag tttcttgtat ttaatcgttt atcggattct tgaagcacac tatcataggc
     8341 ttctttgaca atatccatat cgtctttatc tatccccaat cgtaatgtga ctaagagatt
     8401 actataatcg tgtctaaaac tacgaacaga attgtagaga ccttcaatat gtttattgta
     8461 ggtgtagaga ttttctagct ggagattttt ttggaagtcc aattgtcctt gaatcatttc
     8521 acgaatgttt ctgtctaaaa agacaatcat aatgaagaag aggacaagtg aaataacaac
     8581 acagagtttt cgaagctcca aagttgaaga atgagtagtg ttttcaagat acatgaggat
     8641 ctgtaacagt agggtgtacc caaacataaa aaagttagca actataataa tatgttgaat
     8701 cggagaattt gatttctgct tttgaagtat ggtaaaactc cccttgaata atttaataaa
     8761 gagaaatgat agacaaagag gtgcaataga tgaagggatg gatattaata gagagctttg
     8821 ataatcggtg atactaatat taaaaaaagg gaagataaag aaagtaatca atcttaaact
     8881 aaggttgttg aggatatcag ggaagagacc attgaaaatc tttattttta atggtttttt
     8941 agtcttagtg gataaaagga aggagagaag aagataatag atatcctcac cccagaattt
     9001 aatgataaac caagaagagt ggttataaat aaaattaaag gctaaattaa aaataaggag
     9061 taggaaaaaa tacctcagac gaatcttctg tcccattaaa taaaggaaaa gaataatttc
     9121 taggcctgca cttaaaaggg tgagaaaaag tagccataac gttgttaaca tcctctgcct
     9181 ctttcctcaa caatctgtgc aatctttcct atcttcatac gggatactgg taggacttga
     9241 ccattaatta aggtagcttc ataattggtc aagttgacag agataatcat atctgtattg
     9301 acgatatagg accgatggca tgggtagagc tttttgtgta tctttttaaa gtctgccaga
     9361 tttgctcgga tatccatgag ggtatggata gtctggaggt gaacatggtg tttgatatct
     9421 gatgtggata ggtatagaat ttgatccata ggaaggttta ttaattgaga ctctgttttg
     9481 tagagaaaaa actcatccgt ggtagttgcg ttaataggga agacttgagc aatggtttcc
     9541 cctatttctt ttctaaagct agcttcatct aaggttttat tgatgtattt ataggctgta
     9601 acgccaaaag cttgaggcat gaactctata tgtgtagtga caaaggcaat gatagcataa
     9661 gggttatttt gacgtatgat tttagcgata tcaagtccct tcttatcttc acctttaatt
     9721 tcaatatcaa gaaagaaaat ctgatcgctt gtattagaag tgatagctga taacaactgg
     9781 tcaggtttgt caaaagactg gacacaagat agatcttttc cgaaggattt aagttcatgt
     9841 gccacagcct cttccaagcg acccatctga atagaattat cttctaatag gtaaatcttc
     9901 aaggtctagt cctctctttt atgacgaata ctgtttattg aaaaattgta acataaagaa
     9961 aacggttttt caatttttta tgagtataaa atgagatttt ttttttttct gaattttaga
    10021 aataatatac attaggaatt accattcggg acatatagcc actttttggg acgctagctc
    10081 tgatagagac acttgaatgc tatactaaag atgtgattga gagatcacac gataaaaatt
    10141 ttaggaggta gttgccatgg caactcaaac aattgaaaac tttaacaccc tcgacctcga
    10201 aacacttgct agtgttgagg gtgggttgtc ctgtgatgag gggatgctgg cagtaggagg
    10261 acttggtgca gtaggtggcc cgtggggagc tgtcggtggg gtgttagtag gtgcagcctt
    10321 atactgtttc taatttgtat gggaggaatt tatgaataat aaacaacttg aaagatttaa
    10381 aaaactggat acaaatgcat tgtctaatgt aagtggtcaa ggctatggtg ctcaatgtgt
    10441 tattggtact accggaatga cgattgtcgg tgcagctttc tttggcatcg caggtgcagg
    10501 agctggattt gcaggcggta gcacagcatt ttgttatgat acagctaaat aatcttcatt
    10561 tgagataggt gatacaaatg aagaaatacc taatcatttt ttcgactatt gcgatgatat
    10621 atttatatag caaagtacta ttgtcatcag gaaatatcta tcaacttttg ttagcatcaa
    10681 taggattctt tttcttttta tttggagtct ataggcagta tagaaagaat tagttaaagc
    10741 tttttcaata agacatggac tgaatcaaaa atgatattca gtcttttttt tactactcgg
    10801 gacatatagc cactttttgg gacgctagct ctgatagaga cacttgtatg ctatactaaa
    10861 gatgtgattg agagatcaca cgataaaaat tttaggaggt agttgccatg gcaactcaaa
    10921 caattgaaaa ctttaacacc cttgacctcg aaacacttgc tagtgttgaa ggtggtgtat
    10981 gtagctgggg aggttttgct aaacaaggag tagctacagg agttggtaat ggtttacgac
    11041 taggtatcaa aacacgtact tggcaaggtg ctgtcgcagg agcagctgga ggtgctatcg
    11101 taggtggtgt tggttatgga gcaacatgct ggtggtgatg gattatgttt gatttgaaaa
    11161 gttatatttt agggatggtt tccatggctg ttatgagttt tttagataag ccaattatgt
    11221 catttcttga aaaacacaag gctaccaatt ccgttaagaa gaaatcttcc gttaagaaga
    11281 aatcctaact gaaatgtctt gtcaattgct ggtctgtgaa tagcatgtga attatgattg
    11341 aaaatttcga tataagagaa gagttatttg taatcatgac caaaaaacgc ctagtgtctc
    11401 taatgatgtc tatgggcttc gtccttgttg ccttacataa ctttggagaa aaactgaatt
    11461 ttggacttca atgcctaaat cttatcgggt tatgtttatt tctctttctt atgtgtacgg
    11521 ttatcaagga tataaggtca gacaagtagt gacatttatg tcactacttt tttatcggct
    11581 tccaatctat aataaaattc atagattatg cacagactag ctaaaaacac tttaaggaga
    11641 aaagtatgtt taaaaactca aaaccgtatt tactggctac cattctcatc gtaatgggcc
    11701 tcgctaatct atttagaagc ttggatgcag ttcaccatac cattaacttg ctagggctaa
    11761 cggtgcttct ttatagctta ctttttaaaa agtgggtaca gtttcaaaag taacctttgg
    11821 tcactttgaa cgtaagatgc ttgcaaatgc ttatttttga tgttcccgaa gtaaaattat
    11881 tcttgctaat gatagcggag attatattat atttgattgc atatctttgt aatagagaaa
    11941 acaaagatat gtatattcgc ctatttaaag tatcagtact aatgacacta ctgtattaca
    12001 tctccagtag aatttaatcg ctaagggctt acttgaaatc ttacagctgt ataataaaat
    12061 acagagagga atagagttaa atgtaatagc ttattaggtt tgcaagactg actgaggtta
    12121 ttcatagttt aggtgtttta tcatgaagtt aaagaatatt agttcgagtg tattgcgatc
    12181 ttttagaacc atcactgctg cgttggcagt tttccttata agtatcagcc tttctctcta
    12241 caaaagcaag atctcgccag gaacttggct aacagtcgga gcactagctt tcgtagtcat
    12301 ttttgttaat ggactgctct accgtatgct taagaagcgt ccagattcag taaatctgtt
    12361 aacaatacgg cagtccttca ttgtctttcc tgtcatcaca tttctagtgc ttagtgtaga
    12421 gttttacaca ttactaacat tcagtgatac cacagaccgt atagtactag ccgtattaat
    12481 gcttttgtta atcctctgtg attttctatc ttaccttcaa gtcaaaaaat attttaaaca
    12541 ataaacgcat ttgcttgatt attctgtaag caatctataa gatatttgca taaaagtgtt
    12601 ataataagaa agtgattaag taaatatgtg aaaattagag gaagatttcc aatgattgaa
    12661 ggatgttctt taggaattac cattcgggac atatagccac tttttgggac gctagctctg
    12721 atagagacac ttgaatgcta tactaaagat gtgattgaga gatcacacga taaaaatttt
    12781 agggggtagt tgccatggca actcaaacaa ttgaaaacct taacaccctt gacctcgaaa
    12841 cacttgctag tgttgaaggt ggtggatgta gctggggagg cgcaggtgga gcgactgttc
    12901 aaggagctat cggaggagct atcggaggag cgtttggagg taatgtagtt ttaccagttg
    12961 taggctcagt tcctggttat ctagctggtg gtgttctagg tggtgcaggt ggtactgttg
    13021 cctatggagc aacctgctgg tggagctaat ctatggtata ttttattata ggttttgttg
    13081 ttgctttgtt aggtaatatc tttttcaaaa aggtcaataa aaataaacat aaaaaataat
    13141 cttgaacata tattgaatag ctccctgtca agtggacaat gaaataataa aatattaggc
    13201 gacggccttg ttcctcattt caagaggggc aaggccgtta ttgcgctctt gaaaacgttg
    13261 atgattgtaa aaatagatgt
//
