LOCUS       c00021_JAHOCU0..       16588 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHOCU010000029.1 Bifidobacterium breve strain MSK.22.34
            NODE_29_length_18021_cov_317.985, whole genome shotgun sequence.
ACCESSION   JAHOCU010000029
VERSION     JAHOCU010000029
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 03:08:24
            Original ID  :: JAHOCU010000029.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16588
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16588
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2626:6588]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2627..6588
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..16588
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16588
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03882))"
                     /tool="antismash"
     CDS             3..173
                     /locus_tag="ctg21_1"
                     /transl_table=11
                     /translation="AANIRTFKTCAYYLPLAGIVASLVVFLLTVKIDENMHDRIVEQLE
                     ARLASEETDKQ"
     CDS             591..1247
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 140.9; E-value:
                     8.7e-43)"
                     /gene_kind="transport"
                     /locus_tag="ctg21_2"
                     /transl_table=11
                     /translation="MPVISATNLSIGYKNSPIVSDINLRLNTGRIVCLLGANGAGKTTL
                     MKTLLGRIRPVSGEVTYTGTNINEMSAAIDHPSFFPYLSGRENVEVVSAFWGLDVDPET
                     ALNNVGINHAAHGRKAKDYSTGMKERLELCLALVPHPRFLFLDEPQNGLDPDGIASLSE
                     TLRAYRDRGNCVVISTHLLHEIQGVPDECIVIRHGRAAQFTDLTGVNLADLYQGR"
     CDS             1250..1978
                     /locus_tag="ctg21_3"
                     /transl_table=11
                     /translation="VSAVSPVRALVAYYWNVWYFLAAVFGAVASLLLGSWISGAANGTP
                     IAGGYSFFFTGTQPVICLALLFVCDARVAKAHYGGLPRHVYSAWKPCSLRTIFRALILA
                     AVNLLSVLCFDVIMVLMGTGMHPNLAVVLCFVVLQSLLTALIYSIVEIAVNPEVAGIVS
                     AILCYVWVLLPGDLSDYATPYVANALRVVGLNLNGTVMSPAETASRSSVGPVVVVVPIV
                     VLLVVYVLLSWFRREGVDRK"
     CDS             1975..2601
                     /locus_tag="ctg21_4"
                     /transl_table=11
                     /translation="MKSLLRIERVALIRWSMLAFVAVLLLPLFFLRYGSMGAVAQSAMV
                     MALPITTAGLVFSHARVPRSYRSFSIHDRLLLRFTLKSLLLGVAVSICLTLLYGFAVGF
                     IVNKRPLSLHVALMFAFTAVVLSLACFVLRLWASPVVAWSIVGFFIVAGLPVSSGMFEG
                     SPILHAVIPTTWMLSGARFAGYVIPVGVVVAMASAWLLLKAVKRV"
     CDS             2627..5386
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     201.6; E-value: 2.7e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_5"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9e-29, bitscore:
                     90.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.6e-13, bitscore:
                     39.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.3e-09,
                     bitscore: 28.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRIAALPVDKFPKKGSSALSVFADTVISEPGIRAVLENSAPSFYA
                     AVTKNLAEDSKTERTKVLKVARSALKYLSRLTTRATPFSTFATVGVLENVVSNPDGLEL
                     EVGQRRILERIAVGIDDIEKTFTFNPSAYLLGERLYIPSPSKSQETISVRYSEAVQAVK
                     QVTEGRLIGLEQLSSTLATKFGTSEGLSAFIDGLIDSGILLAAPISYQMRDWKEDLASS
                     DVTSTVQLFSLARFSGTFPSNLIDDTGLAIELMGRLFSFSTQNRNIESFTERYISRYGN
                     FRFPANQVIDNYDGIGLLPPLESEDLQPAGQGKARFDLTNKFLSEVIFTNSDKSSIDLS
                     RYASRILREWPAVEFASSYDVILKVEKVNSQTCEASTNFVFDDIGTIPLAGRAMARFAE
                     LSAEMKNNHREIVTRASGLERTERLPLLYRYNSPRPDFLSGNSSVSGNALSLGFLPHVE
                     QAVSIVGLSDISVFESSGKMYCFDERHQKVANIHLPGLVNQDLLSGIGRSLVQISQMNQ
                     ATPYWSWLGYENHANHLPEIRLGVTILSREKWKLTNRGIGALDDLKRVLADRRVPRYIY
                     AGASDNKILLDTSAFDHLRLLKHVIENSDEDIWIERGVEPEDLGVTKSESDDKARFATE
                     IVISVSSTDWAETATLPVAQIPPVGLNLDLSKRSVLESSTAFTFVVLCNDSNQERVLAT
                     AFDVLDDAGLEAYFVRYSEEGRPSLRIRVRGSFDDTFIRVFCDSVLSLRLATDVEFNLR
                     LPEYSRYGGPECFKYLESFWCLESTQLVKMFTRLSSDTPEQVQKAKSNYMRFLIQQLGF
                     TRHYVSAVAESYEHEFEADRHSIRKAARALRSVFSSDDMPEVFTDEMQEVLARFSSCQL
                     QSNASAQDVKQSIAHMSANRLGLDRKDEAIFWRALLNHLRSADFGGEE"
     CDS             5383..6588
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     104; E-value: 1.3e-31)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_6"
                     /sec_met_domain="LANC_like (E-value: 1.1e-23, bitscore:
                     73.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTRNDIQQEVTLIASNLEDIIPIRYQEANRTKSFNINGGTPAAI
                     LYLSVLDALFPDAGYDVQAHNYATSMILEYKHTPNIGIGLFGGTTLLAWCLQSISRGGS
                     RYQGAIRELESRIVFQARQQLTFLSNVNAPISSEYYDVISGLSGVVLYGMRFRSDGLRL
                     ISRQICSRFCELLATSNFHAFGSLSATSGQDSVAQKTTTDYGYAHGILGVLMSCILSDV
                     NHDNNMEPFAAIRQLVDISNHSRNYILPYSSSDYTETVSNGRYAWCYGNMPFYFLSLML
                     KPVDPIIAESLLNVAIAPLKVNTSQVHDLGVIGLVDNSICHGRAGIVLGLHPYLSHKDS
                     RPIRDQLLEEIDCSVANPIDSGFLEGDLGTLAVRVALEYTDSIAHLPAFFPFVSPTLWE
                     GI"
     CDS             6585..7457
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 139.1; E-value:
                     3.2e-42)"
                     /gene_kind="transport"
                     /locus_tag="ctg21_7"
                     /transl_table=11
                     /translation="MIARALNVTLIYGKSRNPVLHSLNLEIDSGQVLPILGGNGTGKTT
                     LLKALSGLLRPHLGRILIDDSDLYQKRGSALRRLSSSLYSERSFYYRLSARENLRYFLS
                     LRGIYGRTAMSSIDMALDRFDLLGLQDIPFMHLSLGQRKRLGLARAFAAPASLYILDEP
                     TANLDAKSCRLVYQAMTDKSADGASILFSTHNVADLATSTGNVIYLKNGNATRVHLETR
                     DSITARKRFRIVGSLDPESIASIPEVSCVISQSEVEVDIPVGKSLGSVLQSFERIGIEV
                     NEVIDDRSR"
     CDS             7459..8268
                     /locus_tag="ctg21_8"
                     /transl_table=11
                     /translation="MHSFLIGLYLYLRREFLELVTYKLSLMLGVVSAVVGIVQFAFLAV
                     FLQQGNSFPSLQNYGGSVMAFLVSGALFTGFMSSSLSSFSQLISSEQRTGTLEAVLTTP
                     FSIGRVIAYAAVSSFIQLVIGTFLMITFFGIAFSIPFNVNPWQLILVMILGYFTLVGLG
                     LAGGGVLLVTKKGDPVTWLLTTFTTLFSGVLYPVEILPQWLQSISWYVPTTRILSSLRG
                     ALTGYTSMFMLDVVYLIVASIVSMSIGLLVFRWGLNRAIWDGSATSY"
     CDS             complement(8562..12857)
                     /locus_tag="ctg21_9"
                     /transl_table=11
                     /translation="MRFGKKGAGAVASITAAAALLACLVPVALADNGGGGSGEDGGGSG
                     GGPTQTADVHWIYKDSWPATLDGMKTALSDAKVRLSSDLANGQNQFVNMNKTLSDAIDE
                     CQRSYTGEGNADCRLVAVGYVRLADGSFNGSYVSSNAKNRWEAQWKAEAKGDYTYQGQK
                     YSTSTTWKDKLGTRSVDSLAQESIDSNPNASFRVIVLAQNQPPVDYKLNVTTSHKQKTD
                     MQVGSTDPIGDVIHADNGGSAIRETLNGTAIIHYENGPYLPAKSVSKPISFPSNGDTQL
                     DDLASPKDFGMEHWAEGTYWIDIQVPKQGRMQAAVDTADRDPTESWKVSSVPPEPPVKK
                     IEDGVSADRMTNRTTITYGTGRGGYEMRFRDVIEPNGVEYSVDNYRLIDRIDGNRDVSG
                     EFEINWDKASNTVSAARSADKGEMPMDHVYEFSFDVTVSKPSDFQQVKDHAWGKWNHEP
                     EADAGKKQFDTWRPNPDKSWIRLNAKGQWEAVIDPKETNRTGADDMTLLDGDRVASVVN
                     GTIAKNLIQAPETLTLTDDWSAADYLFDADDKSKIKVYEADAGTDRESSVTDIANHGRD
                     VTDQWTITMEGTTVTATAGRAYREGLKGLKTAKQVTLLIPGKAAYANGKGAGQVRDDFG
                     KQASDELSFCTAPDGKALTNKGSQTVNTHTIPTNEPKICGYIPPVVKDVVGESSQGGDQ
                     ASVDGRVVYPGQRLEYRLETQPHLPGNLAYSVSEVAVTDTYDEHLEVDKQTLEVTDLST
                     GRFIPKTEYETQWNDAQHAVRLVFSDGYVKTNWRNGANPRIIVRFEGTVAKDAPTDTKI
                     GNQWALTLNNMITPSNKVWNEPPDFTPVKKDTQADPSISIDGKTALLGDRIYYRVTIDA
                     KQTNQAYKVWRLGMTDDWDDEYLSLDAKRIEVTDTATGKDVTAKFNIAAIDGVAYVYAK
                     TADTKVPATGETIKGDPQPKNLKEYAEKKDHDPLKEPAIDQSMLGTSYEVSLPMTVIKV
                     TDGHIVKNKATQVVNDTRKDTNEVANPLKPVNPSKDVVVKVDGESIDKRSVYLNGLFLY
                     RLDSSVLPAHRAYQKVTDWSITDPLDTEHDQYTGQWAVYAMRDLTEQGRVIARKGVKIA
                     GSGFDASVYGGELFTLTQDDKGVVTVTATQRMLDLVSGNDESEQAWTAFIQCKRVKTGE
                     HIANRFDETLNGTKRPSNQVETHTPDMTPSLKIEKWDEASGWPAGDRDQVKDALAMQGD
                     TRIVFTITNTSTTDPDTKQGAWYRTKDLNLKDQLVAGDGRVTDLEYPADWDSRVLKPGE
                     SVEVKGILKGVTDHHTDRATVTGTPLVECVVSDPDPFDGKDETSAPDDAVTIDGRLVCP
                     DTEVVSNTDDWNGYRTGLAHTGAAIQGVIAAAITLLAVGVGLVAARRFRHGNSAGGRHS
                     ESAQSSDIADTDEDVAETTDEIPYESSVS"
     CDS             complement(13162..13473)
                     /locus_tag="ctg21_10"
                     /transl_table=11
                     /translation="MSQRIHLSENQLHAGLVFPQMKETTPVKKRPIVRTILFPNSSRAL
                     VDKTGKILSVLMGPEQIIGISGFQIRTRLGKNGVQCRSDWGQNVRKCVDLVQIDKIFR"
     CDS             13969..15174
                     /locus_tag="ctg21_11"
                     /transl_table=11
                     /translation="MSTFNPEGIALKQRLAFNPERIALARRLEGVTQKELSTRSGLSQA
                     KLSKLQNGIISFNESDAVKLSGALDYPISYFEESGTVIPLSELTYRKTSRSSMGELNSV
                     STEYSLLMDVIQKLCHVLKMKKNPAAWIDEIAPHEQSLSEEKIERLAIRTRECLGLKPD
                     GAVPNVTRAIERAGIIVSPMRSLNMRGGANLTSEGVTAPSSQWHAMCIGYLGNGALGGD
                     RLRFTKAHELGHLILHRYRKPDSPQLVEREAHIFAGAFLISQLDARLVLKSNLSLRDFL
                     PIKAGWGISIAALISRSHNLGIIDRQRYTSLNIQLSGKGWKKQEPVPVGIENPLLLKQM
                     ITSAYGFKTDQGLKIDSIGLASELGAPFRYLDYWSDGLDDEGMHWGIAANRFEQRPNRM
                     IA"
     CDS             complement(15508..15765)
                     /locus_tag="ctg21_12"
                     /transl_table=11
                     /translation="MNDNHNENEEPFDGTSEDSTLEDQMSAHIAAIAASGVAAEAEALA
                     NRQADMAAKERRETRLAILAAIGIFGAVIVYIITHIAENH"
     CDS             complement(15912..16319)
                     /locus_tag="ctg21_13"
                     /transl_table=11
                     /translation="MDYSMEVSVLGDRISIGEEAHVITLGVNTGFPAGSTAGLAYTLSP
                     LQARVLGAQMRAAADAAEGHPGMPSDEEVNAAAKVFCGGVWNGFDPASMMPTEQFDRFW
                     GDGEGHQLYLEIARHALIAARMSILAGQNES"
ORIGIN
        1 ccgccgcgaa catccgcacg ttcaagacct gcgcctacta cctgccgctc gccggcatcg
       61 tcgccagcct cgtcgtcttc ctcctgaccg tcaagatcga cgagaacatg cacgaccgca
      121 tcgtcgagca actcgaagcg cgcctcgcct ccgaggaaac cgacaagcag taagaaatcc
      181 aactacaaac aaaaagacct tgggtgggtt gtcatctata gatgacaacc cacccaccac
      241 tcaagtcgtt cgaatcgtaa ctgcgcaatt atttacagta agtagttatt cgcattgcgg
      301 gcaactgctt actgtccatt acgttcagat tcgaaagatt ggagaagtca tggccacttt
      361 tgaccttgat acccatgttg aggaaactga gggggacgct cgtcctctga ttacctcgaa
      421 gttcatgtgc acccctggct gcccgaccgg cggccttgcc tgcttcactt cccaatgtac
      481 caatggttgt agcttcaccg gtggaagcaa gcattagcaa cgtcgtcgta gcatcgtgcg
      541 ttcctagagg caagccttgt ctctaggaac gcctttttgg aaggtggatc atgccagtta
      601 tatcggcgac caatctctcg attgggtaca agaattcccc gattgtcagt gacatcaact
      661 tgcggttgaa tacgggtagg atcgtctgtc tgctcggggc gaacggcgcg ggtaagacca
      721 cgttgatgaa gacgctgctc gggcggatca ggcccgtgag cggggaggtc acatacaccg
      781 ggacgaacat caacgagatg tccgcggcga tagaccatcc cagtttcttt ccctacctgt
      841 ctggtaggga gaacgtcgag gtggtctccg cgttctgggg tctggacgtg gacccggaga
      901 cggcgttgaa caatgtgggc atcaaccacg cggcgcatgg acggaaggcg aaggactatt
      961 cgacgggtat gaaggagcgt ctggagctgt gtctcgccct tgtgccgcat ccgaggtttc
     1021 tgttcctcga tgagccgcag aacggattgg atcccgatgg catagcctcc ttgtccgaaa
     1081 cgcttcgcgc ctatcgggac agggggaact gcgtcgtcat ctccacgcat ctgcttcatg
     1141 agattcaggg agtcccggat gaatgcatcg tgattcgaca tggccgggcc gcgcaattca
     1201 cggatctgac cggggtaaac ctcgcggacc tgtatcaggg gaggtaaagg tgagtgccgt
     1261 ttctcctgtt cgcgcgttgg tcgcctatta ctggaacgta tggtattttc tcgccgcggt
     1321 gttcggagcc gtggcgtccc ttctgctggg ttcgtggatt tcaggcgcgg cgaacggaac
     1381 cccgatagct ggaggataca gcttcttctt caccggcacc cagccggtga tttgtcttgc
     1441 gctgctcttt gtgtgcgatg ccagggttgc gaaggcgcac tatggaggtt tgccccgcca
     1501 cgtgtattcc gcatggaagc cgtgctcgct cagaaccata ttccgggctt tgattctggc
     1561 cgctgtgaac ctgctgagcg tattatgctt cgacgtcatc atggttctga tgggtaccgg
     1621 gatgcatccg aatctggccg tcgtcctgtg cttcgtcgtg ctgcaaagcc ttttgactgc
     1681 cctgatttat tcgatcgtcg agattgccgt caatcccgaa gtcgccggga tcgtctcggc
     1741 cattctttgc tatgtatggg ttcttctgcc gggcgacttg tccgactatg cgacgcccta
     1801 cgtcgcgaac gccctacggg tcgtcgggtt gaatctgaac ggcaccgtga tgtcgccggc
     1861 ggaaacggcg agccgatcgt ctgtcggccc tgtggtggtg gtcgtcccga ttgtggtgct
     1921 cctggttgtc tatgttttgt tgagctggtt ccgtcgcgaa ggagtggaca ggaaatgaag
     1981 tccctattgc gtattgagcg cgtggcattg atccgttggt cgatgctcgc ctttgtggcc
     2041 gtgctgctgc ttccgctgtt ctttttgcgt tacgggagca tgggcgcggt ggcgcagtcg
     2101 gcgatggtga tggcacttcc cataaccacg gccggccttg ttttctccca tgcgagggtg
     2161 ccccgctcat atcgttcctt cagcatccac gatcggctcc tgcttcgctt taccttgaag
     2221 tcactattgc ttggtgtcgc ggtcagcatc tgcctgactc tgctgtacgg atttgccgtc
     2281 ggatttatcg tcaataagag accgctctcg ttgcatgtcg ctttgatgtt tgcgttcacc
     2341 gctgtcgttc tttcccttgc atgcttcgtc ctgcgactct gggccagtcc tgttgtcgct
     2401 tggagcattg tcggcttctt catcgtcgcc ggccttccgg tcagctccgg catgttcgag
     2461 ggctcgccga ttctgcatgc cgttataccg accacatgga tgctaagcgg ggcgcgattt
     2521 gccggttatg tgattccggt cggtgtagtt gttgccatgg caagtgcatg gctgctgctt
     2581 aaggcggtga aacgtgtcta gatatactct gctcggatct ccatacgtga ggattgcagc
     2641 gcttcccgtc gacaagtttc ctaagaaagg cagttccgcg ttatcggtgt tcgcggacac
     2701 cgtcatatcc gaacccggta ttcgtgcagt tctagaaaac tctgctccat cattttacgc
     2761 tgctgtcaca aaaaatcttg cagaagattc gaagactgag cgaacaaagg ttttgaaggt
     2821 agctcgaagc gcgctaaaat acttatcgcg ccttacaact agagcgactc ctttttcgac
     2881 ttttgcaacc gttggagtgc ttgagaatgt tgtatcaaat cccgatggtc ttgagttaga
     2941 agtaggacag cgacgtattc tcgagcggat agccgtaggg attgatgaca ttgaaaagac
     3001 cttcacattt aacccatccg cttatcttct tggtgaacgg ctttacattc catcaccatc
     3061 aaagagccaa gagacgattt ctgttcgtta cagcgaagcc gtacaagctg taaaacaagt
     3121 aacagaaggt cgcctaattg gtcttgaaca acttagctca acactcgcaa ccaaattcgg
     3181 aacctctgag ggcctaagtg cttttatcga tggccttatc gattccggca tactccttgc
     3241 cgcaccaatc tcctatcaaa tgagggattg gaaggaggat ctagcatcgt cagatgttac
     3301 ctcaaccgta cagctatttt cgctggcacg attcagtggc acgtttccaa gtaatctcat
     3361 cgacgataca ggattggcaa ttgagttgat gggaagactg ttctcatttt caactcaaaa
     3421 taggaatatt gaatccttta cggaacgcta tatttctaga tatggtaact tccgttttcc
     3481 cgccaaccaa gttatcgata actatgatgg cattggtctg cttccgcctc ttgaatcgga
     3541 agaccttcag cctgcagggc aaggtaaagc tcgatttgat ttgaccaaca aatttctatc
     3601 tgaggttata tttacaaatt cagataagtc aagtatcgat ttaagccgtt atgcttctcg
     3661 catattaaga gaatggccgg cagtggaatt tgcttcatcc tatgacgtca tactgaaagt
     3721 cgaaaaagta aattcccaaa catgcgaggc ttcgaccaac tttgtgttcg acgatattgg
     3781 aacaatccct ttagcaggac gtgccatggc taggtttgct gagctctctg ccgagatgaa
     3841 gaacaatcat cgtgaaattg tcacccgagc atctggcctt gagcgcaccg agagattacc
     3901 actcctatat cgttataatt ccccgaggcc ggattttcta agtggaaatt cttctgtatc
     3961 cgggaatgct ctatccttgg gatttttgcc tcatgtcgag caagctgttt caatcgttgg
     4021 tttgtcagac atctcagttt tcgagagttc cggcaagatg tactgcttcg atgaaaggca
     4081 tcaaaaagtt gcaaatatcc accttcctgg cttggtaaat caagacttgc tatcgggaat
     4141 aggtagatca ttggtgcaaa tctctcaaat gaatcaagcc acaccatatt ggagctggtt
     4201 gggttatgaa aatcacgcta atcacttacc ggagatccgc ctaggagtca caatactatc
     4261 acgagagaaa tggaagttga ctaatagggg aattggggcg cttgatgatt tgaaacgagt
     4321 tttggctgat cgaagagttc ctcgatatat ctatgctggt gcgtcagaca acaagattct
     4381 gcttgatact tcagctttcg accatcttcg actcctaaag cacgtcatcg aaaactctga
     4441 tgaggatatc tggatagaga gaggcgtcga accagaagat ttaggtgtta cgaagtctga
     4501 gtcagacgat aaagctaggt ttgctacgga aattgtcatt tcggtttctt cgactgattg
     4561 ggcggagacg gcgactctgc ctgtcgctca gattccgccc gtcggtctca atctagactt
     4621 gtcaaaacgg tccgttctag agagttcaac cgcttttacc tttgttgtgc tatgcaacga
     4681 ctctaatcag gagagggttc ttgcaactgc ctttgatgtt cttgatgacg ctggtctcga
     4741 agcatacttt gttcgctact ctgaggaagg tcgcccaagt ttacgtatcc gcgtgcgggg
     4801 aagctttgac gacacgttca ttcgggtgtt ttgcgattcg gtactctcgc tacgcctcgc
     4861 gacagatgtc gaattcaatc ttagacttcc cgagtattca cggtatggag gtcccgagtg
     4921 ctttaaatat ttagaatcgt tctggtgtct tgagagcacc caactggtta agatgtttac
     4981 ccgcttatca tcggataccc ccgagcaggt acaaaaagcc aaaagcaatt atatgcgttt
     5041 ccttatccag caactggggt tcaccagaca ttacgtatct gccgtagcag aaagctatga
     5101 acatgagttt gaagcagatc ggcattctat tagaaaagcc gccagagctc tgcgaagtgt
     5161 ttttagttcc gacgatatgc ccgaagtgtt taccgacgaa atgcaagagg ttcttgcgcg
     5221 tttttcatcc tgccagcttc aaagtaatgc ttcagcccaa gacgttaagc aatctattgc
     5281 acacatgtct gcaaatcgcc ttgggcttga tcgtaaagac gaggccatat tctggcgggc
     5341 tcttctcaat catctaagat ccgcagattt tggaggtgag gaatgaagac acgtaatgac
     5401 attcaacagg aggtgaccct cattgcaagt aatctcgaag atatcatccc cattcggtat
     5461 caagaggcta atcgtacgaa aagctttaac attaacggag ggactcctgc cgcaattcta
     5521 tatttaagtg tccttgacgc attatttccc gatgctggat atgatgttca ggctcacaac
     5581 tacgcgacaa gcatgatttt ggaatataaa cataccccaa acattggaat tggactgttc
     5641 ggggggacca cactattggc ttggtgtctg cagtcgattt cccgtggagg aagcagatat
     5701 caaggcgcga ttagagaact tgaatcgagg atcgtctttc aggcaagaca acaattgaca
     5761 tttttatcaa acgtgaatgc gccaatatca tccgaatatt acgacgttat atccggactc
     5821 tctggcgtgg ttttgtatgg catgcgattc cggtccgatg ggctgcgatt gatttctcgg
     5881 cagatttgca gtagattttg cgaactatta gcaacttcga atttccacgc cttcgggtct
     5941 ttatcagcca cttcgggaca ggattccgtg gctcagaaga cgaccaccga ctatggttac
     6001 gcgcatggta ttttgggagt attgatgagt tgcattcttt cggatgtgaa ccatgataat
     6061 aatatggaac cattcgctgc gataaggcag cttgttgata tttcgaatca ctcgagaaac
     6121 tacatacttc catactcttc ctcagattat actgaaaccg ttagtaatgg acggtatgcc
     6181 tggtgttacg gcaacatgcc cttctatttt ttgtcactaa tgctgaaacc ggttgatcca
     6241 ataattgcgg aatctctatt gaatgtcgct attgctcccc tgaaggttaa taccagtcaa
     6301 gtacatgatc ttggcgtaat cggtcttgtt gataactcta tatgccatgg ccgagcggga
     6361 atagtcctag ggcttcaccc ctacttgagc cacaaggata gtcggcctat tcgcgatcag
     6421 ctccttgaag agatcgattg ttctgttgcg aatcctattg acagtggatt tctcgaaggc
     6481 gacttgggca ccttggctgt ccgagtggca ctagaataca ccgactctat tgcgcatcta
     6541 ccggctttct ttccttttgt ttctcctaca ctttgggagg gaatatgatt gctagagcat
     6601 taaatgtgac actgatctat ggaaaatcga gaaatccagt cttgcatagt ttgaaccttg
     6661 aaatcgattc agggcaagtt cttccaatcc ttggcggtaa tggaacagga aaaacgacac
     6721 tgttgaaagc actatcgggg ctacttcgcc cacacttggg tcgaatccta attgatgatt
     6781 cggatcttta tcagaagaga gggagtgcac tgcgaaggct ctcgagctcg ctctactccg
     6841 aaagatcatt ttattatcgc ttgtcagccc gagaaaatct ccgctatttc ttgtcgcttc
     6901 gtggcattta tggcaggact gcaatgtcgt caattgacat ggctctggac agattcgatt
     6961 tgcttggatt gcaggatatt ccattcatgc acttatccct agggcaacga aagcgactag
     7021 gacttgcgcg agcgttcgct gcgccagcca gtctctatat cttagatgaa cctacggcaa
     7081 acctagatgc caagtcatgc aggcttgtct atcaagccat gacggacaag agcgccgacg
     7141 gagctagtat actattctct acccacaacg tggccgacct tgctacctcc acaggaaatg
     7201 taatatatct taaaaatggg aatgcgacac gtgttcatct cgagactcga gactccatta
     7261 ctgcccgcaa gcgttttaga atagtcggat ctcttgaccc tgaatccatt gcatcaattc
     7321 ccgaagtgtc ttgtgtgatt tctcagtccg aggtcgaggt tgatatacct gttggtaagt
     7381 ctcttggatc agtgcttcaa tcctttgaac gaattgggat cgaggtcaac gaagtaattg
     7441 atgaccggag tagataaaat gcattctttt ttaatcggcc tctacctgta tttgcggaga
     7501 gaattccttg aactcgtaac ttataagctc tccttgatgc taggtgttgt ttcagcggtt
     7561 gttggcatag ttcagtttgc tttcttggct gtttttctcc agcagggaaa cagttttcct
     7621 tcattacaga attatggtgg aagcgtgatg gcgtttctgg tctctggagc gctttttact
     7681 ggttttatga gttcttctct ctccagtttc tcgcaactaa tatcctctga gcagcggaca
     7741 ggtacattgg aagctgtttt gactacacca ttttctattg gccgagtgat tgcatatgct
     7801 gcggttagct catttattca attggtaatc ggcacgtttt taatgatcac tttttttggg
     7861 attgcattct ctatcccctt caacgttaac ccgtggcaac tcatattggt catgattctc
     7921 ggctacttca cacttgttgg cctcgggctc gcgggtggag gagttctttt ggttacaaag
     7981 aaaggcgacc cggtgacatg gttgttgaca acttttacga cattattttc cggagtactt
     8041 tatccggtcg aaattcttcc acagtggctt caatcgatta gttggtatgt gccaaccacg
     8101 cggatattga gttctctccg gggggcatta accggctata ccagtatgtt tatgcttgat
     8161 gtggtttacc ttatagttgc aagcatagtt agtatgagta taggattgct agtatttaga
     8221 tggggtctaa acagagctat atgggatggt tccgcgacaa gttattaaat aatcatacat
     8281 ttgggatatt gaagtttgac aatatggcat agaaaagcgt ttcttgtcaa atatcatatg
     8341 aactttggga ttgacatact ctattagaat attgtaccag attaaggtca ttatttcaaa
     8401 aaaatgactc tattctaata gaatgtttcc ttctttcgtc gcgccaaaag aaacatcaat
     8461 tgtaatccgt aataatttga tgaatacatg atagttcttc caatcgtaag atactccgac
     8521 tggaagaact atcatgacgg gaagcaggtc cgacgtccgg gtcagctcac ggacgattcg
     8581 taaggaatct catccgtagt ctcggcgaca tcctcatcgg tatccgcgat atcgctggac
     8641 tgcgccgatt ctgagtgacg gccgccagca ctgttcccgt gtctgaaccg gcgggcggcg
     8701 accagtccca cgccgacggc gagcagggtg attgccgctg cgatcacgcc ctggatggcg
     8761 gcgccggtat gggcgagccc ggtccggtag ccgttccagt cgtcggtgtt gctgaccact
     8821 tcggtgtcgg ggcagacgag cctgccgtcg atcgtgaccg cgtcatcggg tgcggacgtc
     8881 tcgtccttgc cgtcgaacgg atccgggtcg gagacgacgc attcgaccag cggcgtgccg
     8941 gtgaccgtgg cgcggtcggt gtgatgatcg gtcacgccct tgaggatgcc cttgacctcg
     9001 acgctctcgc cgggcttgag gacacggctg tcccaatcgg cgggatattc gagatcggtc
     9061 acccggccgt cgccggcgac cagctggtcc ttgaggttca ggtccttggt tcggtaccat
     9121 gcgccctgct tggtgtcggg gtcggtggtg ctggtgttgg tgatagtgaa cacgatgcgc
     9181 gtgtcgccct gcatggccag cgcgtccttg acctggtcgc ggtcgccggc cggccagccg
     9241 gaggcctcgt cccatttctc gatcttcagg ctcggggtca tgtcgggcgt gtgcgtctcg
     9301 acctggttgg atggacgttt ggtgccgttg agggtttcgt cgaaccggtt ggcgatgtgt
     9361 tcgccggtct tgacgcgctt gcactggatg aacgcggtcc atgcctgctc gctttcgtcg
     9421 ttgccgctga cgaggtcgag catgcgctgg gtcgcggtaa cggtgaccac gcccttgtca
     9481 tcctgcgtaa gggtgaacag ttcgccgcca tacacactgg cgtcgaagcc gctgccggcg
     9541 atcttcacgc ccttgcgggc gatcaccctg ccctgctcgg tcaggtcgcg catggcgtac
     9601 acggcccatt ggccggtgta ctggtcatgc tcggtgtcga gcgggtcggt gatgctccag
     9661 tcggtgacct tctggtaggc gcggtgcgcg ggtagcacgg agctgtcgag gcggtagagg
     9721 aacaggccgt tgaggtacac gctccgcttg tcgatggatt cgccgtccac cttcacgacc
     9781 acgtccttgg acgggttgac gggtttgagg gggttggcga cctcgttggt gtccttgcgg
     9841 gtgtcgttga cgacctgcgt ggccttgttc ttcacgatat gtccgtcggt gaccttgatg
     9901 acggtcatcg gcaggctcac ctcgtagctc gtgcccagca tcgactggtc gatggccggc
     9961 tccttcaacg ggtcgtggtc cttcttttcg gcgtattcct tgaggttctt gggctggggg
    10021 tcgcccttga tggtctcgcc ggtggccggc accttcgtgt ccgcggtctt ggcgtacacg
    10081 taggcgacgc cgtcgatcgc cgcgatgttg aacttcgcgg tcacgtcctt gccggtcgcg
    10141 gtgtcggtga cctcgatgcg cttggcgtcg agggagaggt attcgtcgtc ccagtcgtcg
    10201 gtcatgccga gtctccagac cttgtaggcc tggttggtct gcttggcgtc gatggtcacg
    10261 cggtagtaga tccggtcgcc cagcagcgcg gtcttgccgt cgatgctgat ggacgggtcg
    10321 gcctgggtgt ccttcttcac cggcgtgaag tcgggcggct cgttccatac cttgttgctc
    10381 ggggtgatca tgttgttcag ggtcagggcc cactggttgc cgattttggt gtccgtgggc
    10441 gcgtccttgg cgaccgtgcc ctcgaagcgg acgatgatgc gcgggttcgc gccgttgcgc
    10501 cagttggtct tcacgtaccc gtcggagaac acgaggcgca ccgcgtgctg cgcgtcgttc
    10561 cactgggtct cgtactcggt cttcgggatg aacctgccgg tggacaggtc ggtgacctcc
    10621 agggtctgct tgtccacttc aagatgctcg tcataggtgt cggtgaccgc cacctcgctg
    10681 accgagtacg cgagattgcc gggcaggtgg ggctgggtct ccagacggta ttccaagcgt
    10741 tggcccgggt agacgaccct gccgtccacg gacgcctggt cgcctccctg cgaggattcg
    10801 ccgaccacgt ccttgacgac gggcggtatg tagccgcaga tcttcggctc gttcgtgggg
    10861 atggtgtgcg tgttgacggt ctgggagccc ttgttcgtca gcgccttgcc gtccggcgcg
    10921 gtgcagaacg acagttcgtc gctcgcctgc ttgccgaagt cgtcgcgcac ctggcccgcg
    10981 cccttgccgt tggcgtaggc cgccttgccg ggaatgagca gcgtgacctg cttcgcggtc
    11041 ttcaatccct tcaatccctc gcgataggcc cggcctgcgg tggcggtcac cgtggtgcct
    11101 tccatcgtga tcgtccactg gtcggtgacg tccctgccgt ggttggcgat gtcggtgacg
    11161 ctggactcgc gatcggtgcc ggcatcggcc tcgtacacct tgatcttcga cttgtcgtcg
    11221 gcgtcgaaca ggtagtcggc ggccgaccag tcgtccgtga gcgtcagggt ttccggggcc
    11281 tggatgaggt tcttggcgat ggtgccgttg accaccgagg cgacccggtc cccgtccaga
    11341 agcgtcatat cgtcggcgcc ggtccggttg gtctccttcg ggtcgatgac cgcctcccac
    11401 tggcccttcg cgttcaggcg gatccagctc ttgtcgggat tcggccgcca cgtatcgaac
    11461 tgtttctttc cggcgtcggc ctcgggctcg tggttccact tgccccacgc atggtccttg
    11521 acctgctgga agtcggaggg cttcgacacg gtcacgtcga agctgaactc gtagacatgg
    11581 tccatgggca tctcgccctt gtccgccgaa cgcgcggccg acaccgtgtt cgacgccttg
    11641 tcccaattga tttcgaactc gccggaaacg tcgcggttgc cgtcgatcct gtcgatgagc
    11701 ctgtagttgt ccacggagta ttcgacgccg ttgggttcga tcacgtcgcg gaaacgcatc
    11761 tcgtagccgc cgcggccggt gccgtacgtg atggtggtgc ggttcgtcat ccggtcggcg
    11821 ctcacgccgt cctcgatctt cttgaccggg ggttcgggcg gcaccgagct caccttccag
    11881 gattcggtcg gatcgcggtc cgcggtgtcc acggccgcct gcatgcggcc ctgcttgggt
    11941 acctggatgt cgatccagta cgtgccctcg gcccagtgtt ccatgccgaa atccttcggc
    12001 gaggcgagat cgtcgagctg ggtatcccca ttgctcggga agctgatcgg cttgctcacg
    12061 ctcttcgcgg gcaggtaggg gccgttctcg taatggatga tcgcggtgcc gttcaacgtc
    12121 tccctgatcg cggaaccgcc gttgtcggcg tggatgacgt cgccgatcgg gtcggtggag
    12181 ccgacctgca tgtcggtctt ctgcttgtgg ctggtggtca cgttcagctt gtaatcgacc
    12241 ggcggctggt tctgcgccag cacgatcacg cggaacgagg cgttcgggtt ggagtcgatc
    12301 gactcctgtg ccagcgagtc aacgctgcgc gtgccgagct tgtccttcca cgtggtcgag
    12361 gtcgagtact tctggccctg atacgtgtag tcgcccttcg cctcggcctt ccactgcgcc
    12421 tcccaacggt tcttcgcgtt cgagctcaca tagctgccgt tgaacgaacc atccgccaag
    12481 cgcacgtagc ccaccgccac cagacggcag tccgcgttcc cctcacccgt ataggagcgt
    12541 tggcactcat cgatcgcgtc gctcaaagtc ttgttcatgt tcacgaactg gttctgcccg
    12601 ttcgccagat cggacgacag acgcaccttc gcgtcactca acgccgtctt catgccatcc
    12661 agcgtggccg gccacgaatc cttgtagatc caatgcacat cggccgtctg cgtcggacca
    12721 ccgcccgaac cgccaccgtc ctcaccggaa ccaccgccac cgttatcggc caacgctacc
    12781 ggaaccagac aggccagcaa cgccgcggcg gcggtgatcg acgccaccgc accggcgccc
    12841 ttcttcccga acctcatacg aaatcctttc ccacatacga cagaagcgcc cctctccggg
    12901 aaagggagga gacggggact ccagaacccg cctcctcccg ggtccctgga agaaaagcac
    12961 gcccgcaagc ccgacggccg gccgccggac cccgaacgca ccatcagcat caccccgcgc
    13021 caggtggttc tgcggcggac aacacaacgt acatggcgtt tttgtggcca acggccattt
    13081 gcgaccattc cgctcatgag ttaaaatagg tcgtgaaata ttccattagt acttgatagc
    13141 agggaagcgg cattgaaata ttcatctgaa gattttgtca atctggacga ggtccacgca
    13201 cttgcggacg ttctgacccc aatcggaccg gcactgtaca ccgttcttgc cgaggcgcgt
    13261 tcggatctgg aaaccagata tcccgatgat ctgttctggc cccatcagaa ccgacagaat
    13321 ctttcccgtc ttgtcaacca acgcacggct cgaatttggg aacaatatgg ttctgacgat
    13381 tggacgcttt ttgaccggag tggtttcctt catctgaggg aaaacgagac cggcgtgaag
    13441 ctgattctcc gaaaggtgga tcctctgact catggagttc ctaagtcaaa tgcgacccgt
    13501 gccagccgtg catacttttc acagagccag tgcatcccga agggacagtt gcaagcagtg
    13561 gatccaggcc tgttcgacga aggaaagctg attcccgatc ttcacgatat tggcttggtg
    13621 tgcacttggg atgagatgac ggatggaggt gtatccatcg tcgtttataa gacagaaggc
    13681 ccggggcgat acggcgaaaa gaaccactat ctatttaaat tcccgctatt tgatagcgtt
    13741 cgtggcgatg agcaatatga gttcattcca ctacaagagg atcaggaaaa tcttctgccg
    13801 aatttgctgg ccgatcagac cgatgtcgaa gatgtggata atacagactc ttcgtcgtcg
    13861 gagaaaaatg agaatgagga cgcaggcatg aattccgaca ataaaggaaa tgaagctaac
    13921 taggaatagc tagtcgtata tagcataaat agatagagag atactgcaat gtccactttc
    13981 aatccagaag ggattgcact gaagcagcgt cttgctttca atccagaaag gattgcactg
    14041 gcacgacgct tggagggcgt cactcagaag gagttgtcca ctcgttctgg actatcccag
    14101 gcaaagctca gcaagcttca gaatggcatt atttccttta atgaatcaga tgcggtgaaa
    14161 ttatccggcg ctctagacta ccccatttct tatttcgagg aatctggaac ggttatccca
    14221 ttatccgaac ttacatatcg aaaaacatcc agatcatcta tgggtgaatt gaattcggtt
    14281 tctacggagt actcattact catggatgta attcaaaaat tatgtcatgt gctgaagatg
    14341 aaaaaaaatc cagccgcatg gattgatgaa atagctccac acgaacaatc gctctccgaa
    14401 gagaaaatag agagattggc tatccgaaca cgtgaatgcc tcggattaaa gcctgatggt
    14461 gccgttccga acgtaacccg cgcaatcgag cgggccggaa tcattgtttc tccgatgaga
    14521 tcattgaata tgcgcggcgg ggcaaatttg actagcgagg gagtgactgc gccttcgtca
    14581 cagtggcatg ccatgtgtat tggatattta ggtaatggtg cattaggagg cgatcgttta
    14641 cgctttacta aagcccatga acttggtcat ctgatcttgc atcgttatcg taaacctgat
    14701 tcaccgcaat tagtggagcg tgaagcccat atatttgctg gagcttttct gatttcgcaa
    14761 ttagatgctc gcttggttct taaatccaat ttatcgttgc gcgattttct tccaattaag
    14821 gcaggatggg gcatttccat tgctgcgctt atctcacgtt ctcacaattt aggaatcatc
    14881 gatcggcaga ggtacacctc cctcaacata caactatcag gcaaaggatg gaagaagcaa
    14941 gaacctgtac ccgtcggaat cgagaatccg ctattgctga aacagatgat tacatcggca
    15001 tacggattta agacagatca aggactgaaa atagattcta ttggcttggc cagtgagttg
    15061 ggagctccat ttagatatct agattactgg tccgatggat tagatgatga aggtatgcac
    15121 tggggtattg ccgccaatcg ctttgagcaa aggcccaatc gtatgattgc ttaatccttg
    15181 gttctgtcaa atcaactttg acatcggcaa cacgtctggt tgttggcgtt cccaggaacg
    15241 ccaacaacct tgggaaacga attgatcatt cacgtcgatt ctaatttaac agaacctaat
    15301 ttctacatag ggttcttccg tttccctctt gagtaagagt ggaagaaccc tattctgata
    15361 tggttgaatt gatttatact caaatggtaa tttaatttga tatataccta ctcaacaaag
    15421 aaatgaattc aattatcgga agcaatgatt tgtagattag atttttaagg tgtagggcca
    15481 tactcgtttc tctttacttt aatcattcta atgattttca gcaatgtgag taatgatata
    15541 aacgatgacg gcgccgaaga tgccaatggc ggcgaggatt gccagtctgg tttcacggcg
    15601 ttccttggcc gccatatcgg cctgccggtt ggccagggct tcggcttcgg cggcgacgcc
    15661 gctggcggcg atggccgcga tgtgcgcgct catctggtct tcgagcgtgg aatcctcgct
    15721 cgtgccgtcg aagggctcct cgttttcgtt gtggttgtcg ttcatggttc tgctccgttc
    15781 ctgattgttg gattgtttgc tttcctgatt gttggcttgc ttgattgctt gcttgattgc
    15841 ttgcatgtcc gattgcctgc atgcaatcaa gtttgattgt ttgattgtct gcatgcgggc
    15901 ttgtttgctt gtcagctttc gttttgcccg gcgaggatgg acatgcgggc ggcgataagc
    15961 gcgtggcgcg cgatctccag atagagctgg tggccctcgc cgtcgcccca gaaccggtcg
    16021 aactgttcgg tcggcatcat gctggcgggg tcgaacccgt tccacacgcc gccgcagaac
    16081 accttcgccg ccgcgttcac ctcctcgtcg gacggcatgc ccggatgccc ctccgcggcg
    16141 tccgcggccg cgcgcatctg cgcgccgagc acgcgggcct gcaatggcga gagcgtgtac
    16201 gccagtcccg ccgtggagcc cgcggggaat cccgtgttca cgccgagggt gatgacgtgc
    16261 gcctcctcgc cgatgctgat ccggtcgccg agcacggaga cctccatcga atagtccata
    16321 gtgtctcctt tccgcagacg catcggcttt cgggatcgcg tctgcatgtt tgactgcctg
    16381 aatgtttggt tgttggcttg tttgcctgct ggattgtcgg attgcctgat tgtttgattg
    16441 tctgacgggt tacggctcgt cgtcgctgtc gagtcggtcg agctcgcgtt cgatggcgtc
    16501 gcgcaggagc tgctgcatgg gcaggtcgtg cgcggcggcc gtggtcttga gccgggtctt
    16561 gagcgacacg ggtatgcgca gtgagagc
//
