LOCUS       c00022_JAHBRJ0..       14197 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHBRJ010000029.1 Streptococcus thermophilus strain Vach57
            Contig_29, whole genome shotgun sequence.
ACCESSION   JAHBRJ010000029
VERSION     JAHBRJ010000029
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:14:21
            Original ID  :: JAHBRJ010000029.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14197
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14197
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[236:9197]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      237..9197
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14197
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14197
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(237..503)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4.5e-12,
                     bitscore: 38.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENLNTLDLETLASVEGGGCSWGGAGGATVQGAIGGAIGG
                     AIGGAFGGNVVLPVVGSVPGYLAGGVLGGAGGTVAYGATCWWS"
     CDS             complement(754..1155)
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MKLKNISSSVLRSFRTITAALAVFLISISLSLYKSKISPGTWLTV
                     GALAFVVIFVNGLLYRMLKKRPDSVNLLTIRQSFIVFPVITFLVLSVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLSYLQVKKYFKQ"
     CDS             complement(1485..1652)
                     /locus_tag="ctg22_3"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIVMGLANLFRSLDAVHHTINLLGLTVLLYSL
                     LFKKWVQFQK"
     CDS             complement(1749..1964)
                     /locus_tag="ctg22_4"
                     /transl_table=11
                     /translation="MIENFDIREELFVIMTKKRLVSLMMSMGFVLVALHNFGEKLNFGL
                     QCLNLIGLCLFLFLMCTVIKDIRSDK"
     CDS             complement(2160..2390)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.3e-19,
                     bitscore: 60.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGVCSWGGFAKQGVATGVGNGLRL
                     GIKTRTWQGAVAGAAGGAIVGGVGYGATCWW"
     CDS             complement(2564..2719)
                     /locus_tag="ctg22_6"
                     /transl_table=11
                     /translation="MKKYLIIFSTIAMIYLYSKVLLSSGNIYQLLLASIGFFFFLFGVY
                     RQYRKN"
     CDS             complement(2745..2945)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_7"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.7e-09,
                     bitscore: 28.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNKQLERFKKLDTNALSNVSGQGYGAQCVIGTTGMTIVGAAFFG
                     IAGAGAGFAGGSTAFCYDTAK"
     CDS             complement(2964..3140)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_8"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 9.8e-12,
                     bitscore: 37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGLSCDEGMLAVGGLGAVGGPWGA
                     VGGVLVGAALYCF"
     CDS             3396..4127
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEEAVAHELKPFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIIRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGETIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNKTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGR"
     CDS             4124..5467
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MMLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLA
                     FNFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLIT
                     FFIFPFFNISITDYKSSLLISIPSSIAPLCLSFLFIKLFKESFTILQKQKSNSPIQHII
                     IVANFFMFGYTLLLQSLMYLENTTHSSTLELRKLCIVISLVLFFIMIVFLERNIREMIQ
                     GQLDFQKNLQLENLYTYNKHIECLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEVYD
                     SVLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGM
                     ETLDFIIVTSIFLDNAIEGAIQTQNPKITISFWEDHCSQLLSISNTISEEKTETKTIFE
                     RGVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     CDS             complement(5485..5646)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_11"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.1e-08,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQV"
     CDS             complement(5661..7028)
                     /locus_tag="ctg22_12"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEGLQK
                     QLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKTNTE
                     VNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQ
                     YATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQF
                     LQNAGQQLSSVETQITDTESKINQADVLLTNTLIQSPEDGILHLSQADKKATMAATGTE
                     LAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSA
                     TETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ"
     CDS             complement(7044..9197)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 306.8; E-value: 5e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_13"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1103.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.9e-45, bitscore:
                     145.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMM
                     TFARDYLLTILSQRFTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALAS
                     TILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSN
                     AMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQ
                     LILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRL
                     NEVYLIESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVG
                     VSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLE
                     NLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARAL
                     LTKSPVLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGR
                     VVETGSHQDLMSYPGFYYQLFRK"
     CDS             complement(9794..9904)
                     /locus_tag="ctg22_14"
                     /transl_table=11
                     /translation="MTQFTTELLNFGSIISVVGKTTVEIIELFEMVPPQG"
     CDS             complement(10211..11956)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     287.7; E-value: 1.1e-87)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 313.2; E-value: 6e-95)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_15"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGTLSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVAIIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNI
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLI
                     DGVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     AMEGE"
     CDS             complement(11949..13706)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 389; E-value:
                     6.4e-118)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_16"
                     /transl_table=11
                     /translation="LFFKESIIAKLWWFFKLEKRRYIVGILALSLVSVLNLIPPMVMGR
                     VIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILATSYRLGQIMRSRLFEHF
                     TKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDASITALVTLITMFFSISWQ
                     MTLMAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQEA
                     ELQSFQETNKMTFEKNMHTMKYDSLFDPLVLLFVGSSYVLTLLVGAFMIQAGQITVGNL
                     VTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIETLLEQESDVQDPAYPLPSIENGRL
                     DFAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGPTGSGKTALVKLLLREHDVNQGAIYLN
                     GHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNIRFGNPDFSIDKVEEATKLAQVYDDI
                     KDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILDDSLSAVDAKTEHAIIDN
                     LKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHDDLLAQGGWYAKTYESQQL
                     EMEGGEAHA"
     CDS             complement(13894..14100)
                     /locus_tag="ctg22_17"
                     /transl_table=11
                     /translation="MRERGQVWSYSEVKRESQLANYNTDGRYLSETTNFELYNFVREYK
                     TSDEIRRIWNPKKDESVIHDKDN"
ORIGIN
        1 tgcctacatc tatttttaca atcatcaacg ttttcaagag cgcaataacg gccttgcccc
       61 tcttgaaatg aggaacaagg ccgtcgccta atattttatt atttcattgt ccacttgaca
      121 gggagctatt caatatatgt tcaagattat tttttatgtt tatttttatt gacctttttg
      181 aaaaagatat tacctaacaa agcaacaaca aaacctataa taaaatatac catagattag
      241 ctccaccagc aggttgctcc ataggcaaca gtaccacctg caccacctag aacaccacca
      301 gctagataac caggaactga gcctacaact ggtaaaacta cattacctcc aaacgctcct
      361 ccgatagctc ctccgatagc tcctccgata gctccctgaa cagtcgctcc acctgcgcct
      421 ccccagctac atccaccacc ttcaacacta gcaagtgttt cgaggtcaag ggtgttaagg
      481 ttttcaattg tttgagttgc catggcaact accccctaaa atttttatcg tgtgatctct
      541 caatcacatc tttagtatag cattcaagtg tctctatcag agctagcgtc ccaaaaagtg
      601 gctatatgtc ccgaatggta attcctaaag aacatccttc aatcattgga aatcttcctc
      661 taattttcac atatttactt aatcactttc ttattataac acttttatgc aaatatctta
      721 tagattgctt acagaataat caagcaaatg cgtttattgt ttaaaatatt ttttgacttg
      781 aaggtaagat agaaaatcac agaggattaa caaaagcatt aatacggcta gtactatacg
      841 gtctgtggta tcactgaatg ttagtaatgt gtaaaactct acactaagca ctagaaatgt
      901 gatgacagga aagacaatga aggactgccg tattgttaac agatttactg aatctggacg
      961 cttcttaagc atacggtaga gcagtccatt aacaaaaatg actacgaaag ctagtgctcc
     1021 gactgttagc caagttcctg gcgagatctt gcttttgtag agagaaaggc tgatacttat
     1081 aaggaaaact gccaacgcag cagtgatggt tctaaaagat cgcaatacac tcgaactaat
     1141 attctttaac ttcatgataa aacacctaaa ctatgaataa cctcagtcag tcttgcaaac
     1201 ctaataagct attacattta actctattcc tctctgtatt ttattataca gctgtaagat
     1261 ttcaagtaag cccttagcga ttaaattcta ctggagatgt aatacagtag tgtcattagt
     1321 actgatactt taaataggcg aatatacata tctttgtttt ctctattaca aagatatgca
     1381 atcaaatata atataatctc cgctatcatt agcaagaata attttacttc gggaacatca
     1441 aaaataagca tttgcaagca tcttacgttc aaagtgacca aaggttactt ttgaaactgt
     1501 acccactttt taaaaagtaa gctataaaga agcaccgtta gccctagcaa gttaatggta
     1561 tggtgaactg catccaagct tctaaataga ttagcgaggc ccattacgat gagaatggta
     1621 gccagtaaat acggttttga gtttttaaac atacttttct ccttaaagtg tttttagcta
     1681 gtctgtgcat aatctatgaa ttttattata gattggaagc cgataaaaaa gtagtgacat
     1741 aaatgtcact acttgtctga ccttatatcc ttgataaccg tacacataag aaagagaaat
     1801 aaacataacc cgataagatt taggcattga agtccaaaat tcagtttttc tccaaagtta
     1861 tgtaaggcaa caaggacgaa gcccatagac atcattagag acactaggcg ttttttggtc
     1921 atgattacaa ataactcttc tcttatatcg aaattttcaa tcataattca catgctattc
     1981 acagaccagc aattgacaag acatttcagt taggatttct tcttaacgga agatttcttc
     2041 ttaacggaat tggtagcctt gtgtttttca agaaatgaca taattggctt atctaaaaaa
     2101 ctcataacag ccatggaaac catccctaaa atataacttt tcaaatcaaa cataatccat
     2161 caccaccagc atgttgctcc ataaccaaca ccacctacga tagcacctcc agctgctcct
     2221 gcgacagcac cttgccaagt acgtgttttg atacctagtc gtaaaccatt accaactcct
     2281 gtagctactc cttgtttagc aaaacctccc cagctacata caccaccttc aacactagca
     2341 agtgtttcga ggtcaagggt gttaaagttt tcaattgttt gagttgccat ggcaactacc
     2401 tcctaaaatt tttatcgtgt gatctctcaa tcacatcttt agtatagcat acaagtgtct
     2461 ctatcagagc tagcgtccca aaaagtggct atatgtcccg agtagtaaaa aaagactgaa
     2521 tatcattttt gattcagtcc atgtcttatt gaaaaagctt taactaattc tttctatact
     2581 gcctatagac tccaaataaa aagaaaaaga atcctattga tgctaacaaa agttgataga
     2641 tatttcctga tgacaatagt actttgctat ataaatatat catcgcaata gtcgaaaaaa
     2701 tgattaggta tttcttcatt tgtatcacct atctcaaatg aagattattt agctgtatca
     2761 taacaaaatg ctgtgctacc gcctgcaaat ccagctcctg cacctgcgat gccaaagaaa
     2821 gctgcaccga caatcgtcat tccggtagta ccaataacac attgagcacc atagccttga
     2881 ccacttacat tagacaatgc atttgtatcc agttttttaa atctttcaag ttgtttatta
     2941 ttcataaatt cctcccatac aaattagaaa cagtataagg ctgcacctac taacacccca
     3001 ccgacagctc cccacgggcc acctactgca ccaagtcctc ctactgccag catcccctca
     3061 tcacaggaca acccaccctc aacactagca agtgtttcga ggtcgagggt gttaaagttt
     3121 tcaattgttt gagttgccat ggcaactacc tcctaaaatt tttatcgtgt gatctctcaa
     3181 tcacatcttt agtatagcat tcaagtgtct ctatcagagc tagcgtccca aaaagtggct
     3241 atatgtcccg aatggtaatt cctaatgtat attatttcta aaattcagaa aaaaaaaaaa
     3301 atctcatttt atactcataa aaaattgaaa aaccgttttc tttatgttac aatttttcaa
     3361 taaacagtat tcgtcataaa agagaggact agaccttgaa gatttaccta ttagaagata
     3421 attctattca gatgggtcgc ttggaagagg ctgtggcaca tgaacttaaa cccttcggaa
     3481 aagatctatc ttgtgtccag tcttttgaca aacctgacca gttgttatca gctatcactt
     3541 ctaatacaag cgatcagatt ttctttcttg atattgaaat taaaggtgaa gataagaagg
     3601 gacttgatat cgctaaaatc atacgtcaaa ataaccctta tgctatcatt gcctttgtca
     3661 ctacacatat agagttcatg cctcaagctt ttggcgttac agcctataaa tacatcaata
     3721 aaaccttaga tgaagctagc tttagaaaag aaatagggga aaccattgct caagtcttcc
     3781 ctattaacgc aactaccacg gatgagtttt ttctctacaa aacagagtct caattaataa
     3841 accttcctat ggatcaaatt ctatacctat ccacatcaga tatcaaacac catgttcacc
     3901 tccagactat ccataccctc atggatatcc gagcaaatct ggcagacttt aaaaagatac
     3961 acaaaaagct ctacccatgc catcggtcct atatcgtcaa tacagatatg atcatctctg
     4021 tcaacaagac caattatgaa gctaccttaa ttaatggtca agttctacca gtatcccgta
     4081 tgaagatagg aaagattgca cagattgttg aggaaagagg cagatgatgt taacaacgtt
     4141 atggctactt tttctcaccc ttttaagtgc aggcctagaa attattcttt tcctttattt
     4201 aatgggacag aagattcgtc tgaggtattt tttcctactc cttattttta atttagcctt
     4261 taattttatt tataaccact cttcttggtt tatcattaaa ttctggggtg aggatatcta
     4321 ctatcttctg ctctccttcc ttttatccac taagactaaa aaaccattaa aaataaagat
     4381 tttcaatggt ctcttccctg atatcctcaa caaccttagt ttaagactga ttactttttt
     4441 tatctttcct ttttttaata ttagtatcac cgattataaa agctctctat taatatccat
     4501 cccttcatct atcgcacctc tttgtctatc atttctcttt attaaattat tcaaggagag
     4561 ttttaccata cttcaaaagc agaaatcaaa ttctccgatt caacatatta ttatagttgc
     4621 taactttttt atgtttgggt acaccctact gttacagtcc ctcatgtatc ttgaaaacac
     4681 tactcactct tcaactttgg agcttcgaaa actctgtatt gttatttcac ttgtcctctt
     4741 cttcattatg attgtctttt tagaaagaaa cattcgtgaa atgattcaag gacaattgga
     4801 cttccagaaa aatctccagc tagagaatct ctacacctac aataaacata ttgaatgtct
     4861 ctacaattct gttcgtagtt ttagacacga ttatagtaat ctcttagtca cattacgatt
     4921 ggggatagat aaagacgata tggatattgt caaagaagtc tatgatagtg tgcttcaaga
     4981 atccgataaa cgattaaata caagaaactt tgacttagct agactcgtta atattcagga
     5041 taatactttg aaaagccttc tgtccgcaaa agttttacaa gcagaagaag aaggtattga
     5101 agctcagatt agcatcccag aacccatcca cttgattggg atggagactc tggacttcat
     5161 tatcgtcact tctatttttt tagataacgc tattgaaggt gccattcaaa ctcaaaaccc
     5221 taaaattact attagctttt gggaagatca ttgttcacag ctattatcta ttagcaatac
     5281 cataagtgaa gaaaaaacag aaactaaaac catatttgaa agaggtgtct ccaacaaggg
     5341 acgagagcga ggcattggcc ttgctaatgt cacagaaatc ttagataact atatcaatgt
     5401 aaacttagaa acacagagta acaatttctc attcacacaa caattaacaa taactaaaaa
     5461 ggcctaacag ccttttttct atacctaaac ttgaggaatg ttatagtctt ttgttggaag
     5521 cgttctttgc cctccgaatc cttttaggaa accatttata taatccatcc acccacttcc
     5581 acctacgact tgttcaagag cgtggttatc aagtgtttca aagttattaa tcgtattgtt
     5641 agccatcagt aattctcctc ctattggtct tgcaagttta gtaacttgtc tttaaagtaa
     5701 ttgaagtagg tcttttggtc aataacgctt gtcacacgac cttctagacc gtaacgtaga
     5761 ttttgggctt ctttttctga aatacttgcc ctagcagtta ctctaaacac attccccctt
     5821 tctgtttccg tggcagaatt atcaatactc tcaagttttc caataattgt ggtaccgtga
     5881 ttaccaacct tatccaaggt cagtcgaact gactggcctt tttgcagttt tggcacataa
     5941 tccgaattca cataataagt aatggcaact tcctgggttt gagtcatatc gggataaagc
     6001 tgggccaact cagttcctgt cgcagccatg gttgcttttt tatcagcttg actcaagtgt
     6061 aagattccat cttctggtga ctggatgagg gtattagtca gaaggacatc tgcctgattg
     6121 attttactct cggtatcggt aatttgtgtt tccactgagc tcaattgctg tcctgcattt
     6181 tgcaagaatt gattttttag agcttctttt ttagtgctat cactattgtc ataagttaca
     6241 actgtgcctg tcccagcctt ttggatttct agattaccta tggaagcatt caagctcgaa
     6301 atattggtat taacttgaga taggtattgg tctgttacac tggcatccgg tgtcgtagca
     6361 tactgactgt tataggcatt taaggttgcc tgatgaggat tgccttcagg taaagtcgtt
     6421 tcatgattgg taatagcttg agagagcgcc tcatactctg agacctgagt ctgcaattga
     6481 ctaatctggt tatcaatagc agaaccggta ttactcgcaa ttgctgcttg gttattaacc
     6541 tctgtatttg ttttagccac acccaagtca atatcctgtg cctgacttag gtaggtgtta
     6601 aaagtactct gataaccaaa ctcgtcttcc tgttcttgga aaagattggt tccctgcgtt
     6661 aggctagatt gcaaggtctt caaacctgat tcctgtcttt ttaaaagttc tagttgcttt
     6721 tgaagcccct ctttttgcga tgcctccatg gtctctgaat actgaactaa ggtgtcccct
     6781 tttttaacaa ccttattagc aaccagttga ttatctatga tggtattgtc actggttgat
     6841 tggattactg cgataacctt ggttggctct atacttcctc tagacgtgac tgtaacttcc
     6901 ttcttagcaa aaaaagcgaa aagaaaaagg aaaataacta acaaaatcaa gggagtaatc
     6961 aaaacagtag acatattgtg gtagcgacga tggtaaaact ctgtgctttt aaacaactgt
     7021 ggattcatcg tgtttccttt tcctcacttt ctaaataatt gataatagaa acctggataa
     7081 gacattaggt cttgatgaga acctgtctcc actacgcgtc cgtgatcaat gactacgata
     7141 cggtcggtcc gctcagcgat actaagcctg tgtgctacaa agatgatcgt tttatctttt
     7201 agtgctagga ggttatcaat aacctgcttt tctgtcaaaa catccaatcc gctagttgct
     7261 tcatctaaga ttagtacagg agatttcgtt agtagtgcac gcgccaaagc gatacgttgc
     7321 ttttgccctc cagacagacc tgctccatca gacagctctg tctgaaaccc cataggcatg
     7381 ttttcaatat cttgacgaat ttctgctatt tcacaagctt tcaaaatatc agcttgcgta
     7441 ataccccgtg ctgcacctaa agtaagattt tctaaaacac taccactaaa tatataggat
     7501 tgctgaggga gatagttaat atgttgacga agagttttct tgtctatgcg actaatattt
     7561 tgaccattaa aatctatgtg ccccttatat ggttgataaa aattgaccaa cattttagct
     7621 agagtagtct taccagatcc actgacacca acaaaactga ttttttctcc ttgtctaatc
     7681 gtcaaactga catcagtcaa agtatcacga ccaaaaccat atttataaga taaatccgta
     7741 acagtgatat ctccatccgc aatgccttct tgataggtat catcactttg tccaaactct
     7801 gattcaatca gatagacctc attgagccta gtattagcta ccttagcaga ctgtaacttg
     7861 gtttgcaggt taatgatatt ttccaaagga ttcgtgaagt aagaaagcaa catattaaaa
     7921 gtaatcaatt gtcctatcga aatggtattt cccatcacca actgagcacc tgtccagagg
     7981 ataagtacat ttaaaataag ttgagcacct tgtttcaatg atgtttgtag tatagataac
     8041 ttagaaaggc gaaaagaatt gtctagatag tcaataaact caccatcaat cttttgatag
     8101 catacttctt cgctggttag tgactttatg gtttcaatcc cattaatgtc ctcaatgatg
     8161 gctgaattaa ccatagcatt actctgcatg acgtcatgat tcattcgctc aaaaggtttc
     8221 ataaaggcaa agacgataag ggtataaatt ggaaccgaac aaagaactag cttgaagaga
     8281 ttgctatttt gtatcaataa cacgcctcct acgataatca caatagagaa atcaaggaaa
     8341 agtgataata tcgtcgaagc cagagcatcg ataatagagt tagcatcact aaaacgtgag
     8401 ataacctccc ctgtacgtct tgtggcaaaa aaagacattg ggagttcaaa gatatgtcgt
     8461 atgtaggaca agataacgtc aatggtaaat cgctgactca gtatggttaa gagataatct
     8521 cttgcaaaag tcatcatttg ttgtaaaaca taggtcacaa ctaatccaat tgagataatt
     8581 cctaaggtag acttcatttg attagggaca tattcgtcta gaataccttg taaataatag
     8641 gaacctaaaa tatttattaa agtaaccaag agactggcaa agacaatatt agctatcaag
     8701 gacctttgtt taaagatcaa agggagaaag tcccagagtc catttttctt atccttatgt
     8761 ggtttataac tgggttccgg tcccataaaa agagtaacac ctgtccactc tttctcaaaa
     8821 cgctctttag tcattttagt tacttttaca cttggatcag ggtctccaat tatcagataa
     8881 tccttggtgc ttttataaat aacataataa tgttgaagct tcccatcttt attaacatga
     8941 gcaataaaag gataaggaac atcttccatc tcaaagagcg acatttcagc ctttatagct
     9001 ctcgtttcaa agccaatttt tttagcagcc tctacaagac ctaaggcagt tgtcccttct
     9061 ttattggtct tcgccaactc acgcagatgt gctaatgaat aatctgaacc atagtacttg
     9121 gccactgatg ccaaggcagc aactccacaa tccctcatat ctatttgagg gacaaaagtc
     9181 ctacgaaaac gaaacatacc aaaccctttc atcacaaatt atcatatgat tagtatgtca
     9241 tattttcagg ataaaaagag ccagcgtccc aaaaagttgc catacgtccc aaacggtaag
     9301 aaaaatctta aagtcatctc cactattacc atttaagccg tatttggggt catttaggac
     9361 aagttcattg aaatcgattt caaagttata caatagttat tagaaggaaa cattctaaaa
     9421 tagtcctaca agcatacgta tttgatctaa ccattattac tgtgccagcc ctggtatttc
     9481 caaaggaaac catgactgct gatagcctcg gagcctatct ctatcgtatg atgtcataat
     9541 ttgattattt ttattccgaa aagggataac attatgaaaa acgtcaatcc atatctcaaa
     9601 aaatcctatc aaaaaaggct aaatcagcct cttgagattc gattactcaa ttatcggttt
     9661 aattttcctt agctttgtaa gtgtatttgt tatcactgtc aatgctattt ttagcgtcac
     9721 tagaggggtt cccttcctta atgcccacct tatttccacc ttgagtaatt gtgccttcta
     9781 tcttttgatt tactcaacct tgaggtggca ccatctcaaa aagctctata atctctacag
     9841 tggtttttcc cactacagaa attatagagc cgaagttaag tagttctgtg gtaaactgag
     9901 tcataggaat aaatctcttt ctagtaatgt tttgcaactc tactataacg gatttattcc
     9961 tttttgtgtt tacacaactt attttacact acctcaacgt ttgcaagtac ctcgagatcg
    10021 agtgtttcaa atgtattatt tgtttgcctt gtcattctaa caacctccta aattattttt
    10081 agctttttct ctcaagctat gattttatta tagggtggta gccaacaaaa aagtagtgac
    10141 ataaatgtca ctactcgatt ttgattttta agaaatcttt tcgaatatag aagctatggt
    10201 ctagattagc ttactctcct tccatggcgc ctgcttgtag gctgtacatc ttgtgatagg
    10261 tgccgccgag ggctaggagc tcttcgtggc taccatgttc aatgatgcgg cccttgtcta
    10321 agacatagat gcagttagca tcttggattg ttgataggcg gtgggcaatg gcaatggttg
    10381 tacggccttg acgcattttt gcaagagagt tttgaacaat agcctctgtc tccgaatcaa
    10441 tattggctgt cgcttcatcc aaaatcaaga ttttaggctg gctagcaacg gttctagcaa
    10501 aggctagaag ctggcgttga ccggttgaga aacttgaacc acgttcggaa actggggaat
    10561 catagccttc aggaagttta tcaataaagt gattggcatc gacaaactca gcagcagctt
    10621 taatctcttc atcagttaaa tcttgataca tggcaatatt ggatttgatt gtgccatgat
    10681 agaggaaggg gtcctgaagg acaagaccaa tattcttgcg cagctctgcc tgactataat
    10741 cacgaatatc cacaccgtct atgagaactc gtcctgattg gaattcatag aatcgcatga
    10801 gcacgttgat aatagaggat tttccagagc ctgtagatcc cacaaaggcg atggtttcac
    10861 ctttattgac agagaaggaa atattatcca aaatctggtg cttgccatca taggagaagg
    10921 agacattctc aaagcgaata ttcccctcag taaccttggc agctgtgtct ctctgttcag
    10981 gctcataggt acgctcgtca atcaaggcaa agacccgacc tgctgagacc atagaggttt
    11041 gtagagtcga gaagttttgt gtcacttcaa tcaagggatc aaagaggcga ttaatatact
    11101 ggataaaggc atacatggta cctgctgtga tacccagata gatacctcgg tagccaaaat
    11161 aggccatgag aacagcataa gccaggagct tcagtagact catggctggg cgtagaaaga
    11221 gagaatccag tgatatagaa cggctggcat aaatcaggtg ttcctcatta atggcatcaa
    11281 actctttttt aagacgcttc tcctggttaa aggcctgaat gatgtgaatc ccttcgatac
    11341 tctctgacag tttggcattt atatctgaaa gcaaggctct ggtcttttca atgatggcca
    11401 ctgatttttt gcgataaagg ttaaccaaaa ggacaatcag aggaagaaag aggacaataa
    11461 gcccggtcag acgaatgtcc aagatcatca tggtgtaaag ggtggtaaca aagataaaga
    11521 tagccgaaat aaaactagac agagttcctg agaacatctc gctaatggtc tcagtatcat
    11581 tggtcaagcg ggaaacgatg gaacctgctg gggtcttgtc aaagtaagac atacccagtt
    11641 tttccatatt ggcaaaggca tctcgacgaa tatctctgac aatgctatag gacacacgcg
    11701 caaagaagag atttcccaga tactggacta gtgtctgcaa gaggtagaga ccatagtagc
    11761 caatcagaat catacttgcc gcctgattca tatcatgaag atagtgatca ataaaataag
    11821 aggccaccaa gggaatgata ctcttgataa ccgttgtgga caagaggaag gtcaaagcta
    11881 gaaaggtcaa gaacttgtaa ggcttgagat aggtcaagag acgcttaaac acagaccatt
    11941 ggttttgatt aggcatgagc ttctcctcct tccatttcta actgttgaga ctcataggtc
    12001 ttggcatacc aaccaccttg agctagtaag tcgtcatgac gcccacgttc aatgatacga
    12061 ccatcttgca tgaccaggat gaggtcagcg tgcaccaccg cactgagacg gtgggcggta
    12121 ataatagttg ttttgtcctt gcgagtatgc ttaagattat caataatggc atgttctgtc
    12181 ttagcatcaa ccgcagataa ggagtcatcc aaaatcaaaa tttctggatt caaaatcatg
    12241 gcccggctca tagccagacg ttgtttttga ccacctgata ggctgacacc cttttcacca
    12301 atgattgttt caaagccttc aggcatatcc ttgatatcat cataaacttg agctaactta
    12361 gtcgcttctt ccaccttatc aatggagaaa tctggattac caaagcggat attgtctaaa
    12421 atagaactgg caaagagaaa ctggtcttga ggaacataac caatcaagct acgcaagtct
    12481 gataggcgat agtctcggat gtcatgtcca ttcaaataga tggctccttg attgacatcg
    12541 tgctcccgca agagcaactt gacaagagcc gtctttcctg agccagtcgg tccaaccaaa
    12601 ccaagggttt gccccttgtc caaggtgaaa tgaatatctc gcaaagtatc ctcatcctca
    12661 aaagcaaagc ggtcaatcgc aaagtctaaa cgaccatttt caatgcttgg aagaggataa
    12721 gcgggatctt gaacatctga ttcctgctct aaaagagtct cgatacgttg gtaggacaca
    12781 tttcccctct gcgtgatatt aaagaggaag ccaatggcca ttaggggcca aaccagcatg
    12841 tccaaatagg taataaaggt taccaaattt ccgaccgtta tctgaccggc ctgaatcata
    12901 aaggccccga caaggagggt caaaacataa gatgagccaa caaagagcaa gaccaaagga
    12961 tcaaaaaggc tgtcatactt catggtatgc atattctttt caaaagtcat cttattggtc
    13021 tcttggaagg actggagctc agcctcctga tagccaaaag acttggttac cttgatacct
    13081 gacaccgatt cttgtacctt attattaagt tcagaaaaag ctgcctggga ttctccaaaa
    13141 gctttgtggg tcttacgtcc caaacgacta gtcgcaaaag ccatgaaagg tagaggtaag
    13201 actgccatca gggtcatctg ccaggaaatg ctgaagaaca tggtgattaa agtcaccaag
    13261 gctgtgatag acgcatccac ggctgacatg acacccccac cagccaaacg ggttagagag
    13321 ttgatatcat tggtggcatg ggccatgaga tcaccagttc ggtacttttg gtaaaaagaa
    13381 ggcgacatct tggtaaaatg ctcaaaaagc cgcgaacgca taatctgtcc caagcgataa
    13441 gacgttgcca agatatacat ccgccaaaca tagcgcaaat agtacattcc taaagccgcc
    13501 aaaagcaaat aaacgagatt caaaagcaag atctgattgg tcaattttcc cgatgtgata
    13561 gcatcaatga cccgacccat aaccatagga ggaatcagat tgagaaccga aaccaaactc
    13621 agtgccagta tcccgacaat ataacggcgt ttttctaact tgaaaaacca ccaaagtttt
    13681 gcaatgattg attctttaaa aaacaagtta ttccccctat ccctacaaaa ggatgattat
    13741 aagtctaatg aaagttattt ccaatagcga taaattgtac catcttctaa ctgaaagtga
    13801 ccaatataag tcaattttcc aaaatcagta gactctggca attgataagc aaaggagtca
    13861 aaattataga ccttgtgccc atcatcaata gaatcagtta tccttatcgt ggataactga
    13921 ttcgtccttc ttagggttcc aaatacgtct gatttcatca gatgtcttat actctctgac
    13981 aaaattgtac aattcgaagt tagttgtctc actgagatag cgaccatcag tgttgtagtt
    14041 agctaattga gactctcttt taacctcaga atagctccaa acctgacctc tttctcgcat
    14101 aatatcggca tcacggccac ttttgataag tatctgcttt aaccgctgtc attgttgctc
    14161 ctagtgtcaa tacagtgact actgtcacat taagtgt
//
