LOCUS       c00010_JAHBRJ0..       11172 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHBRJ010000018.1 Streptococcus thermophilus strain Vach57
            Contig_18, whole genome shotgun sequence.
ACCESSION   JAHBRJ010000018
VERSION     JAHBRJ010000018
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 03:28:26
            Original ID  :: JAHBRJ010000018.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11172
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11172
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[366:1172]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      367..1172
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..11172
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11172
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             367..750
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: adh_short"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_1"
                     /sec_met_domain="adh_short (E-value: 5.7e-31, bitscore:
                     97.5, seeds: 44, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VVKLVTTIGRGGFRMSKVAIVTGAGQGIGFAISKRLVEDGVKVGV
                     LDYDAETAEKAVAELSEDKAFSVVADVSKQAEVAAAFQKVVDHFGDLNVVVNSAGVAPT
                     KSLDTITEEQFQHTFNINIGGVI"
     CDS             1026..1172
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: adh_short_C2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_2"
                     /sec_met_domain="adh_short_C2 (E-value: 1.8e-15, bitscore:
                     47.1, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTFAKDITLKRLSEPEDVAAAVSFLAGPDSNYITGQTIIVDGGM
                     QFH"
     CDS             1560..3392
                     /locus_tag="ctg10_3"
                     /transl_table=11
                     /translation="MPNIEELKQRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMDLERERGITIKLNAIELNYKAKDGETYIFHLIDTPGHVDFTYEVSRSLAA
                     CEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRTEIEDVIGL
                     DASEAVLASAKAGIGIEEILEQIVEKVPAPQGDVEAPLQALIFDSVYDAYRGVILQVRV
                     VNGMVKTGDKIQMMSNGKTFDVTEVGIFTPKAVGRDYLATGDVGYVAASIKTVADTRVG
                     DTVTLADNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPET
                     SQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSE
                     FPDPTRIDAIEEPYVKAQIMVPQEYVGAVMELAQRKRGDFETMEYIDDNRVNVIYQIPL
                     AEIVFDFFDKLKSSTRGYASFDYELSEYRRSQLVKMDILLNGDKVDALSFIVHREFAYE
                     RGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARTDIKALRKNVLAKCYGGDVSRKRKLL
                     EKQKAGKKRMKAIGSVEVPQEAFLSVLSMDEDEK"
     CDS             3798..4139
                     /locus_tag="ctg10_4"
                     /transl_table=11
                     /translation="MDITNFIPSQRQAMLERFQQVEALGLGAVRIELKVANPVGIIYEC
                     YIMSGENYFSDQAVVSFRILYEKDLDRISLDVVDIPGRSSLSNYLQLLEIFEGLQHYLN
                     REFAKVKNT"
     CDS             complement(4074..4442)
                     /locus_tag="ctg10_5"
                     /transl_table=11
                     /translation="MKHKKMKQKRHKLAKERKNVSGEPGELIAKRYFMYLKRFQAVGFL
                     NPLQIRLIAETFAHIPTSYFFDENRNDWWNYYQMEVDYCEILNFQHKKKHLITIRCLCI
                     FYLSKLSIKIMLQAFKNL"
     CDS             4600..4845
                     /locus_tag="ctg10_6"
                     /transl_table=11
                     /translation="MALKLVRKVDRKKDIFELRINTEGIFARSLFFRLEKANEEEDNVA
                     SPTYIITNSFKKKTNKTPSKELKKAIKRKSNYKNKR"
     CDS             4960..5289
                     /locus_tag="ctg10_7"
                     /transl_table=11
                     /translation="MKEIKLTPLDKVDRNGFLASYLAERSKKAPEILQHYNNEIECIKL
                     SHKIKQLRENINLTQQELADRMGKSQASIGRIENGTTNPTYKTLEEIAAATNTRLVVDF
                     VPIKN"
     CDS             5623..6480
                     /locus_tag="ctg10_8"
                     /transl_table=11
                     /translation="MKDYGKLFKKFRESRGLVLKDIAKLGVSVSHISRFERENTDLTIS
                     KFMSALNAINMPIDEFMYAANDFQRDEFNEILEKISLFVSARNVSGMEKLLISQVEKIE
                     KRETFYTLNTILIKIRLQDLSDKSYYDESDIQYLSDYLFSVEYWGCYELLLFANTVDVL
                     NHQTMMLLSREMCKRSEFYKDLPNYRRLHSTMLLNCYIISIERDEYIDALYFEKQLNHS
                     CFTETEIYEKLVFHYSKNLYELKKNRSNKAILEMKKCITAMKLANSENLAIKFENHLSG
                     VLKM"
     CDS             6540..7340
                     /locus_tag="ctg10_9"
                     /transl_table=11
                     /translation="MRIIKFPEQISEDIIHYTFLDDIISYNCEKCRGSCCHVNNSLLLD
                     AKTASFLKRTYLKDFIVSDDSVSLLSCGKKCWFHSELGCTINDLGLNKPLTCELYPFHI
                     KKIQNFYIVSFTPCPTFQLNLGEGQRYKDIEDVVLRYIKTGVPVFSPSLHVSEERLKYE
                     IEYQNNFKNTLSEYYRTKTADGTTEFKEYEKWYIYYLDFRWGSIPLSYTSSQANQFWNL
                     YKRVCEDVYKKISYIRTDNIYFIIANQFNKTISKHFQLNFIDKE"
     CDS             7400..7549
                     /locus_tag="ctg10_10"
                     /transl_table=11
                     /translation="MQVSDAIAQIELAEEEVVSSGLSIDIMEIKPSVATELIDGLKGRC
                     PPSV"
     CDS             7751..8848
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_11"
                     /sec_met_domain="Radical_SAM (E-value: 1.6e-22, bitscore:
                     70.6, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYQFSLKKFSDSKSQVIKNVIDFLNNNEISLSKTNTKIVEFSTKI
                     PLKVIQIEVTNKCNLRCMHCYLPDYSKELDRKKISSIVYEAKQLGVMDVDFTGGEPLLL
                     QGLSEIIEEVLKEGMCTTIFTNAVYIPEDFKILIQRYDGIRLKVSLDGWNETIHDSIRG
                     RGTFKRTIKNIEYFRSLGVPVTVNVVLNNKNISGVKYFLELFDRLDVKYAFDRFLPFER
                     NNRLSISDEEFNNAILCIPNIQANCNNISESTFESFYCGAGNSYVFINSSGDVGFCPTL
                     SSTKFCGGNINEKTLNDIWINSKFFNHIRNVRCKYYNECPANYVCQGGCRSRAQFFGGS
                     IGSPDIQECKLAYNLTGIKPKSMSL"
     CDS             8845..9588
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Arginase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_12"
                     /sec_met_domain="Arginase (E-value: 3.9e-34, bitscore:
                     108.3, seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILSIIYDGGSRIPGARFAPTKYYQEAMLYDRKDSDIITINLGN
                     QDLFSIDLESLSRTIAESKVQIALGGDHSVTYLLAKATVREGAYLIVLDAHLDYFKDFE
                     SVVKNWNFLSFLTDIFEKIIIIGERNFEFPSSFDNKIIILSMEEYWLNKSRVLKKLDSY
                     IDESKDIYLSIDIDVLDPSVFDSVSYPIIGGFQMNDFLGIISKILCSDKVYFCDIVEYN
                     PMVGSDNAHIFYQMIQFVKSKLRRI"
     CDS             9595..10767
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_13"
                     /sec_met_domain="MFS_1 (E-value: 4.4e-12, bitscore: 35.5,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKIKKYAALSIYFNRFSSLISEYGYTILINILLSRISVQLVMYFW
                     VVKCLAAIVTNRINISNSKLSRKYLLILLEITKAILLFLLGFGLNHIIVLLVVFIIEVV
                     NVLFSSLLYSCVPIIIDKDSLIKFNARYTSIGSVSYFLAPLFVGLFINKSHFLLFAVYA
                     LLLIVGATSLLFLPNISTLNLKEERKKQNLNITLFNILRSKKIALVLLSGVIVGSIGVV
                     YDTYEVVYLTKYLGISDSMYSFSLSFLAVSFLVMSFLLSFVKQISSHMKAFALGLSFYV
                     LYLLLFSTSSNIYTVLMSYVFLAIGQTMMGIIETNYFQLSLNMKELQKLYIYSETLHSV
                     FSGIAVLVIGSFAFLSSHLVLVFRSLAVFALFILLCYCVFVNLKKLSIDK"
ORIGIN
        1 tatgattctt tctaaaatga tggtttagtc gcttttcatt ataggtcata tgggactttt
       61 tttctacaat caaaaaggct ccataatctc catagaggat ttacccacta cagaaattat
      121 agagccggat atactaaggt taccacctta ggtggcctag gtgatatgga agcactaggg
      181 tttaagtttg aaaaataata cacataaggt cactagtggt gatcttattt gctttcaaaa
      241 agcatgacaa attattaaca acgctttcat aaagtggtaa gattctaaat gagttaagaa
      301 aaagcctatg aaaatgactt tgccagaact tgattaactt agcatattcc aattgagata
      361 gggcttgtgg ttaagcttgt gactacaatt ggtagaggag gatttcgtat gtcaaaagtt
      421 gctattgtta caggtgcagg tcaaggtatt ggttttgcga tttcaaaacg cttggttgaa
      481 gatggtgtta aagtcggggt attggactat gacgctgaaa ctgctgaaaa agcagttgct
      541 gagttgtcag aagacaaggc attttccgtt gtagcagatg tgtctaaaca agctgaggta
      601 gcagcagctt tccaaaaagt agttgatcac tttggcgact tgaatgttgt tgttaatagt
      661 gctggtgtgg caccaacaaa atcccttgac actattactg aagaacagtt tcaacataca
      721 tttaacatta atattggtgg agttatctga ggtgcacaag ctgcccaagc acaatttaaa
      781 tcacttggtc atggtggtaa aattatcaat gcaactttac aagcaggtgt cgtagggaac
      841 tctaacttaa ctgtatatgg tggaactaaa ttcgtagttc gtggtattac tcaaactttg
      901 gcgcgtgact tagctgattc aggtataact gtaaatgctt atgcaccagg tatcgttaag
      961 actccaatga tgtttgacat tgcccacgaa gttggtaaaa tgctggtaaa gatgatgagt
     1021 ggggtatgca aacttttgct aaagatatta ccctcaaacg tttgtcagaa cctgaagatg
     1081 ttgcagcagc agttagcttc ctagctggac ctgactcaaa ctacatcaca ggtcaaacaa
     1141 tcatcgttga tggtggtatg caattccatt aaggttaaaa gggagagcga atggctctct
     1201 ttttttgctt gataaaacat aatgtttctg ataatatagt tataaataat tatgttttta
     1261 aaggtggatt cccatatcag acatcttaca ctatattgct gagcacccat tttttagtct
     1321 tattctattg ggaattattg tactagcctt tggtttagct ccattttcaa gtagttcaat
     1381 agagaacaag cgttcagcta ttattaataa gcactacaat gataatttta agaaataaga
     1441 aggactaaat gcagtcataa agcagatatt agagataggc aaatgcctgt cttttttgta
     1501 taataggagg tgacggttcg ttttttaaca atcacaagta agaattagga aagaataaaa
     1561 tgccaaatat tgaagaatta aaacaaagac aggagaagat tcgcaacttc tcgattattg
     1621 ctcatattga ccatggtaaa tcaacgcttg ctgaccgtat cttggaaaag actgagactg
     1681 tatcaagtcg tgagatgcag gcacaactcc ttgatagtat ggatcttgag cgcgaacgtg
     1741 gtatcactat caaactgaat gccattgagc ttaactacaa agctaaagac ggcgagactt
     1801 atattttcca ccttatcgac acaccgggac atgtggactt tacttatgag gtgtcacgtt
     1861 cccttgccgc ctgtgagggt gctatcttgg tggtagatgc agctcaaggg attgaagcac
     1921 aaacacttgc caatgtttac ttggcacttg ataatgactt ggaaatctta ccagttatca
     1981 ataaaatcga ccttccagcg gcagatcctg agcgtgtacg tacagagatt gaagatgtta
     2041 tcggattaga tgcctcggaa gctgtgcttg catcagctaa ggctggcatt ggtatcgaag
     2101 agattctcga acaaattgtt gagaaagttc ctgcgcccca aggtgatgtg gaagcacctc
     2161 tccaagccct tatctttgac tctgtttatg atgcgtatcg tggcgtcata ctccaagtgc
     2221 gtgtggttaa cggaatggtt aaaacgggcg ataagattca aatgatgtct aatggcaaga
     2281 cctttgacgt tactgaggtt ggtattttca ctcctaaagc tgttggccgt gactaccttg
     2341 cgactggaga tgttggttat gtagcagctt caattaagac agttgcggat actcgtgtcg
     2401 gtgatacagt gacacttgcg gataatccag ccgcagaacc acttcatggt tataagcaaa
     2461 tgaacccaat ggtctttgct ggtctttatc caattgagtc aaataaatat aacgacttgc
     2521 gtgaggctct tgaaaagctc caattgaatg atgccagtct tcaatttgag cctgaaacgt
     2581 ctcaagccct tggttttggt ttccgttgtg gtttcttggg ccttcttcac atggatgtta
     2641 tccaagagcg tttggaacgt gagtttaaca tcgatctcat catgactgca ccatcagtag
     2701 tttaccatgt taacactact gacggtgaaa tgcttgaagt gtccaaccca tctgaatttc
     2761 cagatcctac acgtattgat gccattgaag agccttatgt caaagctcaa attatggttc
     2821 ctcaagagta tgttggtgct gttatggagt tggcgcaacg taaacgtggt gattttgaaa
     2881 ccatggaata tattgatgat aatcgtgtta acgttatcta tcaaattcca cttgctgaaa
     2941 tcgtctttga cttctttgat aaattgaagt catcaactcg tggttatgca agttttgact
     3001 atgaattgtc agagtaccgt cgttcacaat tggtgaaaat ggatattctc cttaatggtg
     3061 ataaggtcga tgcccttagc tttattgtcc atagagaatt tgcctacgaa cgtggaaaac
     3121 ttatcgttga taaacttaag aaaattattc cacgtcaaca atttgaagtt cctatccaag
     3181 cggctattgg tcaaaaaatt gttgcccgta cagatatcaa agctcttcgt aaaaacgtct
     3241 tggctaaatg ttacggtggt gacgtttcac gtaaacgtaa actcctcgaa aaacaaaaag
     3301 ctggtaagaa acgtatgaaa gccattggtt cggtggaggt accacaagaa gccttcttgt
     3361 ctgtgctttc aatggacgaa gatgagaaat aagaatgata gtagaatgtg atgttctggc
     3421 tattttagta aaaagttatg ataaagagga ttttaaaatt taccttctca aagtgtggaa
     3481 ggatttatgc tacgatcata ctaaatactt ttctttttag ggaatggcga tacaaagcat
     3541 gtagcagaat tatagactga cctaaaagca gataaggtaa cttccaatga gatttttggt
     3601 agtcgtcaac aatatgttgt acttagtcat gtagaacaca cttactacat tacgataaac
     3661 actataaaat cagactttag agaatataaa gaagctagat gaggattcat ggggggtagt
     3721 cttatcagga atcccttcgc aagcattttt ctcagcttta ggctataata tacaaaagga
     3781 aagtcgggag ggccactatg gatatcacaa attttattcc tagtcagcga caggctatgt
     3841 tggaacgttt tcagcaagtg gaggccttgg gcttaggcgc agttcgtatt gagttgaagg
     3901 ttgcgaatcc tgttggcatc atttatgagt gctacattat gtcaggagag aattattttt
     3961 ctgatcaagc agtggtatcc ttccgtattc tttacgaaaa ggacttggac cgcatttctt
     4021 tggatgtggt agatatccct ggtcgctcaa gtttgtctaa ttatctccag ttactagaga
     4081 tttttgaagg cttgcaacat tatcttaatc gagagtttgc taaggtaaaa aatacataaa
     4141 catctgattg taatcaggtg tttctttttg tgctggaagt tcaaaatttc acaatagtca
     4201 acctccattt gataataatt ccaccaatcg ttacgatttt cgtcgaagaa gtaactagta
     4261 ggaatatgtg caaacgtctc agcaattaac cgaatttgca aagggttcaa aaaaccaact
     4321 gcttggaacc gctttaaata cataaaatat cgtttagcga ttagttctcc tggctcacct
     4381 gatacattct tacgttcttt ggctagttta tgcctttttt gcttcatttt tttatgtttc
     4441 ataacttttt ccttaagtaa taaagccccc tctaaactaa cctttattta ttatgacgaa
     4501 gacgaatttg cagcgttttt agattccctc cccttaactg tagcgtcaaa ggttatcgca
     4561 aggatacgag aggtttctgc tatcggtata gcagaaacca tggctctaaa gttagtcaga
     4621 aaagtagata gaaaaaaaga tatctttgag cttagaatta atacggaagg cattttcgcc
     4681 cgttcattat ttttccgttt agaaaaagct aacgaagaag aagacaatgt ggcttcacct
     4741 acttatatca tcacaaactc ctttaagaaa aaaacaaata aaacaccatc taaggaattg
     4801 aagaaagcta tcaaacgaaa atcgaactat aagaacaagc gatgacacaa actggattct
     4861 cgcaatccag ttttaagggc tgaaaaagat tcaaccttta aaactggact gtaaagttta
     4921 gtatggatat tgactatatt ttattaagga gagatgcaca tgaaggaaat caaacttaca
     4981 ccacttgata aagtggatag aaacgggttt cttgcttcat acttggcaga aaggagtaaa
     5041 aaggcacctg aaattctaca gcactataac aatgaaatcg agtgtataaa gctatcgcat
     5101 aaaattaaac aattaagaga gaatatcaat ttaactcagc aagaacttgc tgatcgtatg
     5161 ggaaaaagtc aggctagtat cggacgtata gagaatggca ccactaatcc aacatataaa
     5221 acattggaag aaattgccgc tgcaaccaat actagattag ttgttgactt tgttccaata
     5281 aagaactagt ttttgtatac actcaaaaag ctctataatc tctatagtgg ttttacctac
     5341 tacagaaatc atagagtctt ttttatatta tacccttatt agagaacaac atcatacctt
     5401 aactacacca caaaagttag acatcgaaag tctaactttt gtggtgtctt tattttctat
     5461 ttgtttagcc aacagcaatt acaataatgc tttcaaaaat tagaagtaag atagctaaaa
     5521 aactttcttt attcatagaa attaacctcc tatctcacta tatgatataa tacttttaag
     5581 tttatctggg aaattctcgt atatgcaaaa gaggtgcttt ttatgaaaga ttatggaaaa
     5641 ttatttaaga aatttagaga gtctagggga ttagtcttaa aagatatcgc aaagttaggc
     5701 gtatcagtat ctcatatttc ccgctttgaa cgtgaaaata cagatttgac aattagtaag
     5761 tttatgtcag ctttaaatgc gataaatatg cctattgatg agtttatgta tgcagcaaac
     5821 gactttcaga gagatgagtt taatgaaatc ttagaaaaga ttagtttatt tgtttcagca
     5881 aggaacgtgt caggtatgga aaagttatta atctctcaag tagaaaaaat cgaaaagcgt
     5941 gagacttttt atactctaaa tactatttta ataaaaattc gtttacagga cttatcagac
     6001 aaaagttact atgatgaatc tgatatccaa tatttatcag actacctatt ctctgtagaa
     6061 tattggggtt gttacgaact actgttattt gcgaatactg tagatgtatt gaatcatcaa
     6121 acaatgatgc ttttatcaag agaaatgtgt aaacgttcag aattttacaa ggatttacca
     6181 aactaccgaa ggttacactc aacaatgcta ttaaattgtt atatcataag tattgaaaga
     6241 gatgagtata ttgatgcgtt gtattttgaa aaacagttaa atcatagttg ttttacggaa
     6301 actgagattt acgagaaatt agtgtttcat tattcaaaaa atttatatga attaaagaag
     6361 aataggagca ataaagctat tctagaaatg aagaagtgta ttactgcaat gaagctggct
     6421 aatagtgaga atttagctat aaaatttgaa aatcatttat ctggagtgtt aaaaatgtag
     6481 ttggatttgt gtatatggta taaattatca gtgtcaaaat taaatgatat attattgata
     6541 tgagaattat taaatttcct gaacagattt cagaagatat cattcattat acgtttctag
     6601 atgatattat ctcttataat tgtgaaaagt gtagaggatc ttgttgtcat gtgaataatt
     6661 ctttattact tgatgcaaag acagcaagtt ttctaaaacg cacgtatctt aaagatttta
     6721 ttgttagtga tgatagtgtt tcattgttga gttgtggtaa aaagtgctgg tttcattctg
     6781 aattgggttg tacgataaat gatttaggct tgaacaagcc attaacttgt gaattatatc
     6841 cttttcatat taagaaaatt cagaacttct atattgtttc ttttactcct tgtccgacat
     6901 ttcaactgaa ccttggtgag gggcagaggt acaaggatat agaggatgta gttttacgat
     6961 atattaaaac tggggtgcca gtttttagtc cgtctttgca tgtttcagag gaaaggctga
     7021 aatatgagat tgagtatcaa aacaatttta aaaacacttt atcagagtat tatcgaacaa
     7081 agactgccga tggcactaca gagtttaaag aatatgaaaa atggtatata tattatttag
     7141 attttagatg gggaagtata cccttatctt atacaagttc acaagcaaat caattttgga
     7201 atctttacaa gagagtttgt gaagatgttt ataaaaaaat atcatatata cgaacagata
     7261 acatatactt tattattgca aatcagttta ataagacaat ttcaaagcat tttcagctaa
     7321 attttataga taaagaatga tttctatgat ttgttatggg tacttattga ttcttaaata
     7381 aataatggag gatattacga tgcaagttag tgatgctatt gcacaaattg aattagcaga
     7441 agaagaagtt gtttctagcg gtctatctat tgacattatg gaaattaaac cttctgttgc
     7501 tacagagttg attgatggac tcaaaggtcg ttgcccaccg tctgtctaat agaactgatt
     7561 gtaggattag agtctatttc taatcctttg gtttttatat taatattttt ggaagattgc
     7621 agggaattaa tatgacgagc aatgtttact cgattttttt aattggtaca ataagcaagg
     7681 aatactcagg aataatagga ataataaact attttcatta aatttagcta catttttagc
     7741 tttaaaattt atgtaccaat tttcattgaa aaagttttct gattcaaaga gtcaggtaat
     7801 aaaaaatgtt atagattttc taaataacaa tgaaatatca ctctctaaga ccaacactaa
     7861 aattgttgaa ttttcaacga aaataccatt aaaagtgata cagattgagg tcacgaacaa
     7921 atgtaaccta agatgtatgc attgttattt acctgattat tcaaaggagc tcgatagaaa
     7981 gaaaatttca agtatagtat atgaagctaa gcagctagga gtaatggatg ttgatttcac
     8041 tggaggcgaa ccattattat tacagggatt aagtgaaatt atcgaggaag tattaaaaga
     8101 gggaatgtgt acaacaattt ttacaaatgc tgtatatatt cctgaagatt ttaaaatatt
     8161 gattcaaaga tatgatggta taagactaaa agttagttta gatggttgga atgaaacaat
     8221 acatgattca attagaggaa gaggtacatt taagagaaca attaagaata ttgaatattt
     8281 taggagttta ggagtacctg ttactgttaa tgttgttttg aataacaaga atattagtgg
     8341 agtgaagtat tttttggagt tgtttgatcg attagatgtg aaatatgctt ttgataggtt
     8401 tttacctttt gaaaggaata atcgactatc aattagtgat gaagaattca ataatgctat
     8461 tttgtgtatt cccaatattc aagcaaattg taataatata tccgaatcca catttgaatc
     8521 attttattgt ggtgctggca attcttatgt gtttataaat tcgtcaggtg atgttggatt
     8581 ttgtccgaca ttatcctcca ctaaattttg tggaggtaac attaatgaaa agactttaaa
     8641 tgatatttgg attaattcga agttcttcaa tcatattcga aatgtacgat gtaagtatta
     8701 taatgaatgc cctgcaaatt atgtttgtca aggtgggtgt agaagtcgag ctcagttttt
     8761 cggaggttct attgggagtc ccgatataca ggagtgcaag ttagcatata atttaactgg
     8821 gattaagcca aagtcaatga gtttatgaaa atattatcta ttatttatga tggtggaagt
     8881 agaattccag gagcgagatt tgcacccaca aaatattatc aagaagcgat gttatatgat
     8941 aggaaagatt ctgatataat tacaattaat ttaggtaatc aagatttatt ttctattgat
     9001 ttagaaagtc taagtcgaac tattgctgaa tctaaagttc agattgcttt aggaggagat
     9061 cattcagtta cttatctatt agcaaaggcc actgttcgag agggagcata tttaattgtt
     9121 ttagatgctc atttagatta cttcaaagac tttgaaagtg ttgtaaaaaa ttggaatttt
     9181 ttaagttttt taaccgatat ttttgaaaaa ataattatca ttggggaaag gaattttgag
     9241 tttcctagtt catttgataa taaaataatc atcctctcaa tggaggagta ttggttaaat
     9301 aagagtagag ttttgaaaaa gttagatagt tatattgatg agtcaaaaga tatttactta
     9361 tcaatagaca ttgatgtttt ggatccatct gtttttgatt cagtatcata tcctattatt
     9421 ggaggatttc aaatgaacga ttttcttgga ataatttcca aaattttatg ttctgataag
     9481 gtatattttt gtgatatagt tgagtacaat ccgatggttg gaagtgataa tgctcacatt
     9541 ttttaccaaa tgattcaatt tgttaaatca aaattaagga ggatatagga aatattgaaa
     9601 ataaaaaaat atgcagcatt gagtatttat tttaatcgtt tctcatcgtt aatctcagag
     9661 tatggttata ctatcttgat caacattcta ttgtctagaa tttctgtgca attagttatg
     9721 tatttttggg tggtaaagtg tttagctgca atagttacaa ataggattaa tatctcaaat
     9781 agtaaactga gcagaaaata cctgcttatt ctgttagaaa ttacaaaggc aatcttactt
     9841 ttcttactag gttttggatt aaaccatata attgtcctat tagttgtatt cataattgag
     9901 gttgtcaatg tattgttttc cagtttatta tatagttgtg taccaattat tatagacaag
     9961 gattcattga ttaagtttaa cgctaggtat acaagcattg gttcagtatc ttatttttta
    10021 gcaccgttgt ttgttggttt atttattaat aaaagtcact ttttattgtt tgcagtttat
    10081 gctcttcttt tgatagtggg agctactagt cttttatttt taccaaatat ttcgacttta
    10141 aatttgaaag aagaaagaaa aaaacaaaat ttaaacatta cattatttaa cattctgaga
    10201 tccaaaaaaa ttgcattagt tctattatct ggagttattg tgggatcaat tggagttgtt
    10261 tatgatactt atgaagttgt ttatttaaca aagtatctcg gtattagtga ttctatgtat
    10321 tccttttcct tatcattttt agcagtttca ttcttagtaa tgagcttcct tcttagcttc
    10381 gtgaaacaaa taagttctca tatgaaagct ttcgccttag gtctttcatt ttatgttcta
    10441 tatctacttt tatttagtac atcttcgaac atttatacag tactaatgag ttatgttttt
    10501 ctagcgatag gtcagacaat gatggggata atcgaaacca attattttca gttgtcactt
    10561 aacatgaaag aattacagaa actatatatt tactcggaga ccttacattc tgtattttca
    10621 ggcattgctg ttttagtaat aggaagtttt gcctttttaa gtagtcatct tgttttagtt
    10681 ttcagaagtc ttgctgtttt tgctctgttt attcttctgt gttattgtgt gtttgtaaac
    10741 ctcaaaaaac taagcattga taagtaatat ttataaatca gaaaacaagc aaatgagata
    10801 gttaatttat aaagtagaca aacgctattt tgagtgtttg tcttttttta gtcacctagt
    10861 ctgccttttt tcacaagatt gtctgaaaac tgtgctataa tgataacaga attgtgaatt
    10921 gatgaaagtt tgtgaaaaaa cgagcagact ttgacacttt gtgacttata cttgaaagga
    10981 aagttggctc taccatttta gggctagaag gactgtgttc atgtcagaag aaaagcaatt
    11041 gtatggtgca gatttagtgg ttgatagttt gatcaaccat gatgttgagt atgtctttgg
    11101 gattccaggc gcaaaaatcg atagggtttt tgataccttg gaagataagg gacctgaatt
    11161 gattgttgcc cg
//
