LOCUS       c00018_JAHBRM0..       17081 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHBRM010000025.1 Streptococcus thermophilus strain Strac48
            Contig_25, whole genome shotgun sequence.
ACCESSION   JAHBRM010000025
VERSION     JAHBRM010000025
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:16:12
            Original ID  :: JAHBRM010000025.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17081
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17081
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5133:7081]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5134..7081
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17081
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17081
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             548..649
                     /locus_tag="ctg18_1"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             819..1088
                     /locus_tag="ctg18_2"
                     /transl_table=11
                     /translation="VQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             1248..1547
                     /locus_tag="ctg18_3"
                     /transl_table=11
                     /translation="LCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1647..2558)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_4"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2788..2877)
                     /locus_tag="ctg18_5"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2874..3476)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_6"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.4e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALELDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3570..4661)
                     /locus_tag="ctg18_7"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4658..5083)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_8"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-14, bitscore:
                     46.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 4e-07, bitscore: 22.5,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEFGEM
                     YYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSFRTK
                     NSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(5134..5976)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_9"
                     /sec_met_domain="PF04055 (E-value: 1.7e-20, bitscore: 66.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2e-07, bitscore: 23.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 4.1e-25, bitscore:
                     80.2, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANILR"
     CDS             complement(6046..6138)
                     /locus_tag="ctg18_10"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6221..7081)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_11"
                     /sec_met_domain="TIGR01716 (E-value: 4.9e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7321..8157)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.7; E-value: 3.2e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg18_12"
                     /transl_table=11
                     /translation="LVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8151..8717)
                     /locus_tag="ctg18_13"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(8896..9054)
                     /locus_tag="ctg18_14"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9066..9197)
                     /locus_tag="ctg18_15"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             complement(9207..9719)
                     /locus_tag="ctg18_16"
                     /transl_table=11
                     /translation="LAAAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQ
                     PYMTESAYSQELTSQNDAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSD
                     LKNANQSKTNQTETRTVNLNYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPS
                     LPNTTTK"
     CDS             complement(10119..13298)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 497.2; E-value: 1.7e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg18_17"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDHFQKSLEERLRQSNKDMEKRQAQLDGHFASQVWSE
                     EELSVLEQTPASEKLTRLEEFLSQRQENVTKQKSILKAAHEDLAQLQKSLQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELTVQSKDFLQKEEELETWKENIIYAQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLDSLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLIIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVAKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIHKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13295..14503)
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.5; E-value: 8.1e-77)"
                     /gene_kind="other"
                     /locus_tag="ctg18_18"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMEKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 tgacttaagg ttaaaagata tggcagacaa agtttatcag ataattgacg gtaaaatgac
       61 aatcctggag aagtaattta atttatgact aaaaatcagc aaaaatataa ttatgactaa
      121 ggaatatttt attaactaaa tgttgagata gcacaaggaa atatttgtgc tatctttttt
      181 atttattagg aaaagagaaa aaattatgcc aacgaaaata tggttaaaac cagaacaatt
      241 agatttgtat attaaacatt tagaacgatt tagagactta tatagtaaac tagactgttc
      301 tggtatagta aatttgtaac actcctacct aataagttaa actattcatt agaataggag
      361 acataacatg aaacactatc cagacgaaac acgataaaaa attgttcgac tgcacattca
      421 agacggatga acattaaaaa gcttagctgc tgaatatggc gtatcccaag cctcaatctc
      481 taattgggta agacattatc gcaaagaatg ccaaactaat aataaagaaa aatcacagct
      541 tgaactcatg gaggaggttc gtaaattacg tcaagaaaag gcagagcttg aaaaggaaaa
      601 tgatttctta aaaaaagcag cggcattctt tgcaaaggaa atcgattaga ggcatatcgt
      661 tttattgata actataaaga agattttggt ttgcgttggt tgttcttgca tatgaatatt
      721 catcccaatg cttattataa ttatcttaaa aagacaagga ctaactatca tcgtcaaaag
      781 aaagctattc ttaatactat tcgagatatc taccatgagt gcaatggaaa gaagtaaatc
      841 aattcttcga aacagaaagc atcaaacttt ctgatataga gccttcgaaa gttagttata
      901 gggaggtaca aaggaatcaa atcaatacca ctatttataa tgaaaaaggt aatataaagg
      961 atattgatac tagcattata agagatatgt acgataaaag caaacctact ttaaaacagg
     1021 gagcctatat atccgctata gcagcttctc tagaaggggg gtactgcatt tataacagca
     1081 ataattaaaa aaagcgctta gggaaaacta ttagtgagtt tacaaaagac gattgtcttg
     1141 aaatttctaa agatagtgga attggagcta taaaaggaag tactcgaggc attacgatat
     1201 acgccctaac gaattacaca gctactcctg cagcagtagc aagttcattg tgcactgctt
     1261 catttggtat cgctaaagaa gcatacaaat tccgtaaaaa cttaatcaca aaagaagaat
     1321 ttttactaaa ttcgcaaata ttatgtgttg aagtatcagt tagtgcatta tcctcaatat
     1381 taggacatgc tgtaattcca atacctattt taggatccgt tattggaaat aatataggaa
     1441 ctttcctata tgaaatcgct aaagataatc tcacaatgaa agagaaatta ctgatagcag
     1501 attatttcaa agagatacaa gaatataact attttttaga taattaattt gaattatata
     1561 atcatcaact tcagagagat taagaattac tataaacttt tagggaaggc attttctcct
     1621 gactataata tcgcttttca gggatcttat gaatttttaa atatgttttt taaaaatacg
     1681 ttaacctctc ctattttctc tgcttcaggt aaatagatag aaacggttgt cgaataaaca
     1741 aaagaaggta cactcacaat tgaaagcaat tgactaataa ctgcataaat agccaacaat
     1801 tctactccta atctcgacat caaggcatca aacaccataa taaacaaaac actctccaga
     1861 atttcttgac caaccaaagg aataccaaat gttattaatt caaatttagt tgtagatgta
     1921 atggataaag ccttcaaaat cattggataa accataaaca agtaactaag cgatatgaaa
     1981 gctaaggata caatcgttga tatggctgct cccttaattc cgatttgtgg taccagtaca
     2041 taatttaaca caacatctat taatgaactg ataagtccaa cccacataat tggttttgtt
     2101 ttcttttgaa ctcttaataa atttgtcagc gaaaagttta ataatgtcaa tccgatatat
     2161 ggagacatga agactaaata aatggtggat aaggacaata gttgcccttt aaatccatag
     2221 agctgcttca agattacatt tccaaaaata atgacaaaaa ccgcaaaggc aactccgata
     2281 attaaatcta aggttagatt tgatttcaat aaatcatcaa acctgttagt ttgccgatta
     2341 gagtacgcct tagagctttt aatattaaat gacaaactga atgctcctaa aagtccacca
     2401 aaagcaaata agagattctg aataatggaa attcctgaca gagcaattga ggaattgttc
     2461 acagcaaaat gcaatgctat ctgcccaata attacttgac caatatttgt taaaactaag
     2521 ggaaaggcaa atttgttaat ttcttttgaa tctatcattt ttcctctcta aaaggcttca
     2581 aatgtaagta aagatcagat ttaactaaat ttgcataaat aatatgcaaa ataggagttt
     2641 cttctaaaaa tgaaataatt gcctgcttac aatcattagc agatacctca taatcttgct
     2701 gtaatagttc tacaatcttg tctaaagaaa aatttttaga aatgcaataa agtatttctg
     2761 ctcctatttc atcaaatgaa tagtactcta atcaagtaga tcgtatccta tgtattcatc
     2821 tgctacttta tttacaatga aatctctctt acctcttatc acaaaatgtt ctttcatacg
     2881 actactccac ctcctttttg ttcataaaag caggctaaat cagagcccag taacgttcca
     2941 tctaattcca aggcactgca tcgacatccc ccaccacacc atggtagggg acattctgaa
     3001 catttcccag aaatatcatc aaatgtaatt gatcttagtt tattaaatac agcagaatgg
     3061 tgccaaattt cgctaaactt ttgttcttta acatttccag caactaattc atctatacca
     3121 ttcatcaagt cacacccgta tacatctcct ttatgattaa ttgaacatgc tctaactcca
     3181 gcttgacaag atatttccct tggcttatca aaatttatat ctactttttg atgccaaaca
     3241 ttttctaata aatctgatct attataaaat gcaagcggaa aataatgtgt caaaaaaaca
     3301 tcactttcat taggaggaac aattttaaat ttaactttga actctccttt agaaatccgc
     3361 tctgttaaat caagaaaaac aggataccat tgttttttat ctgctaaaat actaccgtca
     3421 ttagccctac cagtaggaca aataaccata actgacatat actcaatacc aagcatatca
     3481 ttcaatctta tactctaaag aaaatatctg ctaaatttgc aaacaattgt gctatcaata
     3541 atttggcaaa tgaattagaa atacaacttt taagttcttt tctctctgtt agaaaatgaa
     3601 taagatacta agcaacaaag agctactata ccaaatatta aataattgct cctaatacta
     3661 aagttatcag caaaaatacc agctaggaaa tcagctaaca taaaactaat cgaaataaac
     3721 aaattatata ctgaccatga tactgctcta tttttttcta ttgacatatt aaatttataa
     3781 taaaaatgat tattgtagtt ggaattaaga acacgcatta ataaaaggat tataatttgg
     3841 atgattagat tagtttgaaa aaacatgagt atagctaata ctggtaacat caagcttact
     3901 tcaaacttaa tttttagata actccccaaa gccatagata tattaaacat aaatagtata
     3961 attcccagca tatctagtga aagtccctgt tcatttaaga atatccctgc ataagaattg
     4021 ctaatcataa ttagagttga gaatgctact cctaatatta ttaataacca tggaatattt
     4081 tgaatattat cgaggctaaa aaatttttgt ttattatttt gttccttttt aatctcgggt
     4141 aatcctatta aatataataa actgaaaatt acaaatacaa tggatataat aataggataa
     4201 atataattcc tatgcaataa aggtggagat ataatcgtaa taatagcaat aaaaatatat
     4261 tttaatgtgt tgagattttt caaaaatgat ttatatacaa cttcgtcatc aattatttca
     4321 aaattataag aaataagaac tcctgaagat aatgattctg acaatccaaa aaatatcgct
     4381 gaaatatata ttatatttga ttttccaaac aataggcccc ataatgctaa aattaataat
     4441 aaatttgaaa tagccaaaat tttcttgtaa ccaatcttac ttgaaatata acttaaagga
     4501 atatcaaaaa ctgagccaca tagctcagta ataactgata aagtagctat ttctgtgaac
     4561 gaaaaaccta agtgctttaa tagtaaaatt cctacaaagt agtacggtaa tccagataga
     4621 aacatattca ttccgtataa attaaaaatc ttcttactca taagttacaa actgggtctc
     4681 taaaatattt tggactcttc tccttaatca agttaacata gcagccaccc tcgcaaattt
     4741 ttaacaatcc acaagataaa cacttagaat tcttcgttct aaaagaacga atccctccat
     4801 acaacggatc atcataccaa acatctaaca aatctttttc aaaggcattc tgcttagttt
     4861 gattaactcc taaaaaagca atgcaaggca agatatcccc attagacatt atttccatct
     4921 tagtatattt tgcacgacat ccataataca tttcgccaaa ctctgaaaat tcaattgaat
     4981 tatttatcaa ctccggataa gcggtgaaaa gatgacatcc ctcagtagca aaatttaaat
     5041 tagcttcccg ttgagttata taatctgtaa catactcatt caaccttctc aaatcagcta
     5101 aatcgtattt tttctttatt ttcgtatatc ctgttacctc agaatattag ctactgaaaa
     5161 tctatctatt ttattctcta tacaaaaatc aaccaattct ataatctgct catagctttg
     5221 ctttgtatac actgcattaa ttctacattt ttttccaacc tctttaaagt acttcgctaa
     5281 tttaatttgt ctatcaggtc tcacccccat taattcaaaa tttaatttag gatctaaagt
     5341 ctgcaaagat aaaaccggtg taatatattt agatttagct agaatttcca ctgtactttt
     5401 ctttattaat tgggcattag ttgttatagt agtctttatc ttcagttctt cacaagctat
     5461 caacaaatta tcaatatcaa aatatctagt cggttcccct cctaaaattg aaacacttaa
     5521 cactccatta tcttttgctt ggcgcaaaat tctttcccaa tctttagcag gtttggcatt
     5581 tctatcttca cgatttgcta aaaaacaaaa accacatttt aaatcacagt acatactggg
     5641 gtatattact agttcaagcg gaaaactcaa tatgttatgt ttttttaatt ttgctacatg
     5701 ctttctcgca ttttgaagag tctcgtcagg atttttcgat gatccctcaa tattattatc
     5761 agaatagata tttaataaga gtactcgctc tagtttccct gcttttattt ctttcttaaa
     5821 aaaggacgta gcaatttcaa aaccatgatt ttgaaccaaa taaagaaaat aagcttcact
     5881 ctcatctaac tcaattcggt caaaagttac tttatttatc aaaattccac caaacttttc
     5941 tagtctaaat aaaaaatctt ctgaaattgt catcatattg aatacctttc taaaaaagca
     6001 gaggaaaata tagcctctgc ttaacttatg ggataaatta ctttatcact cccagccgtc
     6061 accttttgcc atcaccttcc agccgtcacc ttttgccatt gaactagact caaggacttt
     6121 ttcaagctct ttagacatat ttggtactcc tttcgaatat gatactgtga ttatatttct
     6181 tttcaacact tacaataaaa tattcccata tttgcatttt ctaactacta gctaaaattt
     6241 tttctaaatg tccttcataa gtctttgcta agtgatgact tcctgctaat ttcatcgctc
     6301 caacacactt cttcatttca ataattgctt tcacatttcc atcctcttta tattgataaa
     6361 gattttgtgc atacttaaag actaaacgtt catatacttc tgtctcaata aaaaagcatt
     6421 gatttagctg cttttcaaaa tataaagcat ccataaattt ttctctttca acacatgtaa
     6481 tatatccatt taaaagcatc gttgaaatta atcgtctgtt atttggaatt tctttgtaaa
     6541 aatcagaacg cctaaacatt tctcttgcta agaccatgaa aacatcatga tttaatacat
     6601 ctaaagtatt cgagaaaatc aataactcat agtaccccca gtattctaca ctaaagagat
     6661 aatctgttaa atatgtcaaa tcatcctttg tatagtaagt ttctcctgat aaatcctgta
     6721 gacgaatttt caataaaata atattgattt gatgaaattt ttctcgccta tcttccagtt
     6781 ccatctgaga ataaagtaat tttttcatac cttctacgtc acgtgttgac acaaaatgac
     6841 gtactttcga taacagttcg tttaactcat ctctatgaaa atcatggacc gcatacataa
     6901 attcatctat tggcatattg atttcatcta aaataaacat gaactttgaa atcgttaaat
     6961 ctgtttctcc tttctcaaat cgagagagct gagacgttga tataccagcc tttgcgacgt
     7021 cttttaatcg taatcctctc gattctcgaa actttttaaa aatttctcca aattttttca
     7081 tactacacct ccatcacgca tatatgggaa taattttcat ttgctttcat catatcatac
     7141 aataaagaaa aacaaaagtg aggattatca catgaaaaag caaattttac taacacttct
     7201 tcttgtcgta tttgaaggca ttatcgttat cgtcgtggga taaagagtct gggacaaaag
     7261 tcctttagct ccaaaaagca acggcataat gtactgaccc caaaaagtta gacaaataat
     7321 ttaagtaaag gatttagttc tgtattgtac aggactgagt ccttttagtt ttaccttaat
     7381 gcgtttgttg ttgtaataat taatatagtc tgcaattgct tgttccaaat gctcaattga
     7441 cttaaacgtc ttctcataac cataaaacat ctcagactta agaatgccaa agaaggattc
     7501 catcatgccg ttgtctggac tattgccttt acgtgacatg gatggttgga ttcctttctc
     7561 ctctaaaaaa tgatgataga aatcatgttg atattgccat ccctggtcac tatggagaat
     7621 tgtatttttg taatgtttct ctgtaaaggc ttgttctaac atagctttca cttgtatcaa
     7681 gttcggtgac ttagaaagat tgtaggcgat aatttcacta ttgaagccat ctaaaattgg
     7741 cgacaaatag agtttttggc tgcttgctgg aatggcaaat tctgttacat ctgtgtagca
     7801 tttttccaat ggtttggatg cttcgaactg gcgttggatg agattctctg ctttcatacc
     7861 aacctctcct tgatatgaag aatacttacg tttacggcga attctagcgg ttaaaccaag
     7921 tactttcata agacgttgaa ctctcttatg attaatcaca attcctcgat ttctcaattc
     7981 aagagtcatt cgacgatagc cgtaatttcc tttatgctca gtaaaaatgg cttgaatttc
     8041 agctttaatg tcataatcct tatcattttg atccagctgt tttaagtggt aataataggt
     8101 tgaacgagca agcttaataa tctttagaag catatctaaa gaaaactcag ttaccaatcc
     8161 tcggacaatt tccgtttttc ttcttgctct ttttcttccc tcaatcggag ttctctcaac
     8221 tttttaagaa ctgcattctc cgctctaagg tactcatttt ctgcttgaag acgttccatt
     8281 tcttccagtt ttttctttgg cttacgtccc attttagata accttcctct tgttttctca
     8341 acaatagtat acccgttttt cttatagtgt gcgagccagt taggaagcgt cccacgattt
     8401 gggagagcat attcaagaga aactctatct tgagaatagc ctttatatag gactttatca
     8461 atcatttctt gttttaattc aggagagtag taacgattct ttcctttttt agcgatttct
     8521 attccgtatc gatcaatcaa tttaatcatg tagctaagat tagaaatgtt tatcccaaat
     8581 ttatttgaaa gctgatctaa gctatatcct tggtttctaa gttcatagat ttgaacctta
     8641 tcttcataag tcaatttcat aataaaaaca ccccgaaagt tagatttttt ctgtctaact
     8701 tttggggtgc agttcataaa accgttgctt tttgcatgat tgtgatagac ttggtgaaat
     8761 agaattgacc aaaaatcttc tgaaatataa caagagagtg actcgaattt aaaaagctag
     8821 agttccacaa ttggaaatct ctagcttttt tgtgactgag aactttttgt cccagcctct
     8881 actttctact gactactatc ctgcatgccc taagtcgaga tagagaatat ctcgcttagt
     8941 ggcatactct agcgcatgtt caacagcctc aaataaatct gaagctagaa accttttcgt
     9001 aaagacggtt tcgtctttac gcttaaattt cgcaacataa ctatgtttag tcattttttc
     9061 tccttctaat attcatattg tcctttaaca ccactataga tccagtaaac tgctttatca
     9121 taaacttgtt taaaggagat acctaatcga ttggctacat caagaattga aatttgctta
     9181 cattcctcta tattcataaa atatcatcat tttgtcgtag tattcggcaa tgatggaaca
     9241 gatgaggatt cttctaaagt tttaggagtt gccttatcta gatcatctaa cccagatttc
     9301 caaacctgta cttggttgac caataactta ccaggtagtt tcgaatagtt caaattaacc
     9361 gttctggttt ctgtttggtt tgtctttgat tggttggcat tctttaaatc agatacataa
     9421 gttacattat aagagaccat ggcaatggct tgattcgtag tctgattgac aaagatatct
     9481 gctttttcaa aatgataatc caaaatatag tccttataca cttggttcat ggcatcattt
     9541 tgacttgtca attcttgaga ataggccgat tcagtcatat aaggttgaat acgtgtatta
     9601 ttttccccta gtttttcttt cgtatagtac tgtgtcaaaa attcttttac agtatctgat
     9661 gataaaatac ttgctttatc ttctgcttgt ttgtcctcta caagtttagc tgcagccaat
     9721 tcgatttctt ttcgactttg tttggcagta gaatgttgac caatagaatt agcagtaagt
     9781 tgtggtgttg atgaggtaga tatactaaaa aatgaggagg aaattgataa ttacttcacc
     9841 tagctaaaag ttcaacgaat tagggagaca ttaggtagcc tcatattact ttgattagtt
     9901 tttgctataa cattgtcaaa tatgatgaca aaaaaatccg tccgcacttt tttacgagta
     9961 ggacgaatta aatatgttat acaaaccatc agctttttaa caattctaca taaggtagtt
    10021 gttgatgcaa ctaccttttt tctatgctga ttagaacaaa tttgacatgg ctacaactgc
    10081 gattatctga tatagagtat tatataaact gattcctcct accccttatc cacaatttta
    10141 atacggctac tgccatcgtg cgacttgatg ataactagtt gctgagcaat accttctttc
    10201 atatcgtcta cgtggctgat gacaccgacc atgcggtttt caccgatttg ttccagaaca
    10261 gaaatggcct tggtcagggc ttccttatcc agtgagccaa acccttcatc gatgaagaga
    10321 gcttcaacaa cggcaccctt gctggtattt tggacaactt ctgagaggga tagggcaatg
    10381 gccagtgcag cgataaaggt ttcaccacca gacaaggatt taacggagcg ttcactacct
    10441 gtcagctggt catagacgtt gatatccaaa ccgaagtgat cacgcgccct gcgtccttcc
    10501 tcacttagaa caaaggaata gcggttatcc gttaatagtc cgatgtagtt agcattggca
    10561 tagtccaaga tttgttggaa atactgacgg ataacgtaga cctcaagatt aagacgacca
    10621 gttagagcag tattttctcc cttaaccacc ttaaccaaat cactgagttc ttggtgggcc
    10681 ttaaaggcct cttggttact gtcttgaagg gttttagccg cttggtaggt agccgtcgca
    10741 tccttaagtc ccttttccat gacagaaaac tgagcgagct gcctatcata gatttcctga
    10801 caattctgta ctgcttgcgc tagactatcg agatctggtt gttcttgatt ttggagaagc
    10861 tcttgcccct tatgaatctg cgcctgtaat tcttgtttga gcgttgcata ggtcgttaat
    10921 ttggcctgaa gcataggaat agcttgatta tttacctcaa taagccagag ttcgacctgc
    10981 tctaagtcat tagcgagggc tccttcagcc ttgagacttt gctctaattc agcagataat
    11041 cgcttaacat cttgatttac cttatcttta gacttagtta tactctcaat ctgccccttt
    11101 attcctttaa tgtcggcatg aagttggttg taggcttcgc tattttcctt gacttgctta
    11161 ttgtagaggt tcagctcctg atgagcaagg gaaatccgtt cttgatatac ctcaacagac
    11221 tcaagttctg gatgagcttc ctgcaggtcc tctaggcgtt cttgagcttg gtcaagcact
    11281 gccttggcct cttgataggt tttagccaaa tctgtcgctt ttttttgagc cttacctagc
    11341 tcatcttgat atcggatata atctgtctct tccttatcat aacgtttttg taactcttga
    11401 taatactgct caaccttcag gagtagggct tgcccacggt cagtttcata gtctatcgaa
    11461 aaatcaaaat caaaccgtcc cttaacgtgc tcttctaatt cttgatagtg cttttcaaga
    11521 gttgccttga ctttagccac ttggtcaagc aaatcctgac gtttagatgc aacttcactc
    11581 aaggtagcct gacgatttga taaagtagcg acttgctttt ctttttgagc ttgaagcttc
    11641 tccacctgat ccatgagatt tttcaaggcc acttcatcag cctgtgctcc accaacatta
    11701 gggtgttcca gagcaccaca aaccatacaa ggatgcccct cctctaactc tgcctgcagt
    11761 tggacaataa tgagttgacg gcgtgaaacc aaagtccttc ttaactcctc ttccaattct
    11821 ttgagaattt cttgagcttg atcaatatca aaagataacg tttgatgacg tttttcggtc
    11881 tttgtcaact cctgattcaa gttctctatt tctttcaggt cctgagcaag ttgattctcc
    11941 acactgtagc ccacaatctg gaagagtttt tcggcctcat gtaaactatc taaactaaga
    12001 cgattagcct ccaagtcaga caaggacttg ttaagcatct caacctcttt tctagcctgc
    12061 tgataggtct cttccaactg cttgtagtta gtcgttgaac gtttgatttt ctcctgttct
    12121 tgggcaagac tctgggcata gataatattc tctttccaag tttcaagctc ctcttctttt
    12181 tgaagaaaat ccttagattg aactgtgagt tcctcttttt tagccttaac atcctcaaac
    12241 gcctgttgct tttcacttaa ggcttcttga gcaatttcaa ggtcctgctc taattgcatc
    12301 aactgtttcc gatactgctt caaggtccga atggtttcct gcagaccttg agcaaactgt
    12361 aattcctcca gatgcacttt tgcctctgcc tgtccttgag ccccctcctc aatttccaga
    12421 cggtaacgtt ccttggcttg ctccaattct tgaaaaatct ttgccaaatc ttgggcagtt
    12481 tgcaagctct tctgcagttg tgccaaatcc tcgtgggcag ccttcaagat acttttttgc
    12541 ttcgtaacat tttcttgacg ctgagacaaa aactcttcaa gacgtgtcaa tttttcagag
    12601 gctggcgttt gctccaagac ggataattct tcctcagacc aaacctgact ggcaaaatga
    12661 ccatctagct gagcctgacg cttttccata tccttattac tctgacgaag acgctcttcc
    12721 aagctctttt gaaaatggtc aaaaataccc gttccaaaga ttttctttaa aatttgagtc
    12781 ttggtcttag aatcttcttt caagaaacgg ctgaaatcat tttgtggaag gagaataatc
    12841 tgtttgaact gctcagcatt gagccccaaa atctgctcaa tctggtcact cacttccttg
    12901 atcttatccc caagcttttc aatttcctga ccaccaatct tatccacaat gactagagaa
    12961 gccgtcgcct tttgcatggt agtgccccca ccctgcttgg ccctctcttg ctggagaact
    13021 cggtcaatgc gataaaggtg attgccttgt tggaaataga aagtcacctt ggtcaaatca
    13081 tcctctggac cagcgaaagt tgaccgcatc tcctcaacat tacgatcacc actggtcgta
    13141 gcaaacaagg ctaccgtcat ggcatcaaag agagtactct taccagcccc tgtatcccct
    13201 ccaatcaaaa agaggggagc atggtcaaac tgagtgaaat taataacttc cttacgatat
    13261 ggtccaaaat tggtcaattc taactggact ggtctcattg tcgactcctc tcaatctcct
    13321 caaaaacact ttccacaagg gcagtctgtc tctcagataa gacatcgccc ccagttactg
    13381 tctggtaaaa atcaaatacg atttcctggg gcgactgcat ttccaaatct tttaagtgct
    13441 gatcaacggt caagttttct tccctaacat cacccagacg actgaaagta atttctacaa
    13501 tgtctgtccc ataaatctct tccagtcggg cacgcacatt gataccctct aattccttac
    13561 gactagacag ttgaatatca aaggcgaacc aggctttttg acaaggttga ttcttataaa
    13621 attcaggtga catcaaggtt tcaaaagatt cctgtaaagc cacaatcggc cgtttaacct
    13681 ctagagtatg gaaggtctga gacatatcac cagacgcatc caattcaaga atatagacac
    13741 ccttttcttc cttacgcttg gcttctttga cattaaaggc gactggactg cctgaatatt
    13801 gcacgcgctt ggtaggacta gcaaaacgcg tatggatatg ccctaaggca acataatcga
    13861 aagacttgaa aaggtcactg gtcacattgg taagaccacc taccgtatta ctggtttcag
    13921 acaacatcaa ttctcgaaga ccctgaccat cgctatcatc cttcttagaa accgcaaaat
    13981 gcgtcaccaa gacatgagct ttgtcaggat caaaagcttt ttccatatcc tcaagaatgt
    14041 aggtcaaggc atcaccaatc ccctgaattt cctttccctc atcatcctta tagtaaatac
    14101 gagcatcaat aggatcgata aaaggcagca gaaaaatctg gcaattctcc aactcaatgg
    14161 gctcaaaagc ctcctccaaa cgtgtactta aatgaaggcc ctgatgttga aagaagtcac
    14221 gcccaaaatg taaacgttca gccccatcgt gattaccact aatcgcatag acaggaatct
    14281 gctcctccag taccaagcgg gccaaggtct tattaaaaag cttaatcgca tccacagggg
    14341 gcaccgcacg gtcatagagg tccccagaaa tgataacccc atccactttt tcgctaatag
    14401 ccaaatccac aatttgttga aaagcccact cctgctcctc caacaaagac cagccattga
    14461 gggttcgtcc tacatgccaa tctgacgtat gtaaaaactt catgacaacc tcctcattca
    14521 ttttgtctta cttctattgt accttatcaa gctaaatact gcttaaaagt ttcacaggct
    14581 ttgatagttt tcccgttttt tagctgtaaa gatcaaaaaa tctctcccaa gctatcctgt
    14641 actgacccca aaaagttaga caatttatgt aagcaaagga tttagctctg tattgcacag
    14701 gattgagtcc ttttagtttt accttaatgc atttgttgtt gtagtaatca atatagtcta
    14761 gattaccctg cctcaattgg ttaagtaatt taaatacctc taaccaagaa aatcaatatt
    14821 atctattctt ttaattgact tttatagatt ctaagcatta tcatataggt tggtactagt
    14881 gcacatcttg tattttaggc aataatattt actcactttt cgttattgtc agtaccgatc
    14941 ctttttaaat ttttcactat gaaaacctaa aaataatccg aaccctaagg gctcctgact
    15001 ttttacttta ttctaggctt tttttatccg tagcttgtta gctgacttgg aactaggcat
    15061 gtagtattta ctatttccct acttgagatt ttttataagt cacatgcatt attccatctg
    15121 aacgaatggt atgattttta tttcttttag agaaacaccg gtaatagcta attcctatct
    15181 taaatcactt gaaatatatt tataatgtgt tggagtgcta atcagtaccg cttgtagatt
    15241 tttggaagat actaacacac taatgattta atctccttta aaacatgaaa agagaagcct
    15301 ccaaagcttc tcttttataa ttatcaaata atgtacaact agattcttaa taactaccta
    15361 atttagtggt tcaatcatga agcttaattg atagctatct gctgagctaa gcaagaattc
    15421 gtcatgaact ggagcacccc atgtgtcgtc accacctaca cccatttgag cagcaagaac
    15481 tttaatccat gtagcatcag attcttgcaa ctcatattgg tgacgagcat tttcaatttg
    15541 ttcagtactg ttacgcaaag cactgaattc gaatgcttta ttaagtgcgg tgaatttaag
    15601 accattatgg ttatcatcag atactgtgaa ttcacgagta ccatagtgat taccagattc
    15661 ttgtggcatt agatatggag caaatgtctt ttcaacagat gtttcatatc gaccaagata
    15721 ggcaccagga agtttatcac ggtagctttc ttctgcaccg tatccataat agctaaggtt
    15781 tgtaaattgt gaaccgatag caaattctag accaaattca gggaagtttg gcaaacctgc
    15841 tttaccatca tagtttgcag taacaaagat tcgacccttg taatcaactt gataagttac
    15901 cttaacttcg acatcagaca agcctggcaa ttcatgaaca taagtcactt taacagagtc
    15961 gtcttcgatt tgaatttgag tatctgtaac tttactatag tttccagcaa ccttccagcc
    16021 tgccatttcg aatggatatc cagcaccacg atcgttgtca gtgtaagcac gagtgaagct
    16081 aagtttagga cctttctcaa tgaattcaac accattatac ttagcagata ctaaagtatt
    16141 ttgtgcacgt gaaagcaaga ttgagaagtt ttgtccttga ataccgatgt tgaagtcgcc
    16201 ttcaacaaca ttcaaaggtg ctttaactgg tgtttcagtg ctaatctttt caacaacata
    16261 ttgaccacga acaatttcat gacctttagg agcccattca gttgcttccc tcagaacaca
    16321 agcaacttcg taaatttgtt cagaatttga agcctcgact acaaagttaa ctgggaatgt
    16381 tgcttcttcg cctggtttaa catcaaagtg atattcactt tcactaactt ttctaccatc
    16441 ttcgtaaact ctagctagga aagtataagc agaaagatct tcgaagagat tatcattctt
    16501 gatagttact gatttttcat caacagcaat cttaatatta gagtaaagat gtttaactgt
    16561 ttgaagtttt ggagttaggg tacgatctgc aaagacgata ccatttccac aaaattcgta
    16621 gtcagaaggt ctatcatgcc agtcaccacc atatgatagg aattcgctac catttggaag
    16681 tgttttgtaa atagcttggt caatgaagtc ccaaataaat ccaccttggt attctggata
    16741 tttctctaag tcagtgtaga gttgcaatcc accaccagag ttacccattg tgtgcatgta
    16801 ttcacatgaa atataaggtt tttgaggttt gttagttagg ttacctgaag caaagtgttt
    16861 atcactaacg cttgaaagat caactagttt accagttgtg aggtattctt cgatatcagc
    16921 tggtttcgca tacatacgac tttcgatgtc tgtaatgtaa tcaaactcac gacaccatgc
    16981 aacaccttca tagtgaactg gacgagtatt gtcaacacta cggaagtaat cagccatgtc
    17041 agcaatatct ttaccagcat atgattcatt accacaagac c
//
