LOCUS       c00041_JAHBRK0..       14200 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHBRK010000046.1 Streptococcus thermophilus strain Vach60
            Contig_46, whole genome shotgun sequence.
ACCESSION   JAHBRK010000046
VERSION     JAHBRK010000046
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:22:37
            Original ID  :: JAHBRK010000046.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14200
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14200
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[236:9200]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      237..9200
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14200
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14200
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(237..503)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 7.6e-12,
                     bitscore: 38.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENLNTLDLETLASVEGGGCSWGGAGGATVQGAIGGAIGG
                     AIGGAFGGNVVLPVVGSVPGYLAGGVLGGAGGTVAYGATCWWS"
     CDS             complement(754..1155)
                     /locus_tag="ctg41_2"
                     /transl_table=11
                     /translation="MKLKNISSSVLRSFRTITAALAVFLISISLSLYKSKISPGTWLTV
                     GALAFVVIFVNGLLYRMLKKRPDSVNLLTIRQSFIVFPVITFLVLSVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLSYLQVKKYFKQ"
     CDS             complement(1485..1652)
                     /locus_tag="ctg41_3"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIVMGLANLFRSLDAVHHTINLLGLTVLLYSL
                     LFKKWVQFQK"
     CDS             complement(2160..2390)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_4"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.1e-18,
                     bitscore: 60.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGVCSWGGFAKQGVATGVGNGLRL
                     GIKTRTWQGAVAGAAGGAIVGGVGYGATCWW"
     CDS             complement(2564..2719)
                     /locus_tag="ctg41_5"
                     /transl_table=11
                     /translation="MKKYLIIFSTIAMIYLYSKVLLSSGNIYQLLLASIGFFFFLFGVY
                     RQYRKN"
     CDS             complement(2745..2945)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_6"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.1e-08,
                     bitscore: 28.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNKQLERFKKLDTNALSNVSGQGYGAQCVIGTTGMTIVGAAFFG
                     IAGAGAGFAGGSTAFCYDTAK"
     CDS             complement(2964..3140)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_7"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.6e-11,
                     bitscore: 37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGLSCDEGMLAVGGLGAVGGPWGA
                     VGGVLVGAALYCF"
     CDS             3399..4130
                     /locus_tag="ctg41_8"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEEAVAHELKPFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIIRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGETIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNKTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGR"
     CDS             4127..5470
                     /locus_tag="ctg41_9"
                     /transl_table=11
                     /translation="MMLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLA
                     FNFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLIT
                     FFIFPFFNISITDYKSSLLISIPSSIAPLCLSFLFIKLFKESFTILQKQKSNSPIQHII
                     IVANFFMFGYTLLLQSLMYLENTTHSSTLELRKLCIVISLVLFFIMIVFLERNIREMIQ
                     GQLDFQKNLQLENLYTYNKHIECLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEVYD
                     SVLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGM
                     ETLDFIIVTSIFLDNAIEGAIQTQNPKITISFWEDHCSQLLSISNTISEEKTETKTIFE
                     RGVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     CDS             complement(5488..5649)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_10"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.8e-08,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQV"
     CDS             complement(5664..7031)
                     /locus_tag="ctg41_11"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEGLQK
                     QLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKTNTE
                     VNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQ
                     YATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQF
                     LQNAGQQLSSVETQITDTESKINQADVLLTNTLIQSPEDGILHLSQADKKATMAATGTE
                     LAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSA
                     TETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ"
     CDS             complement(7047..9200)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 306.8; E-value: 5e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_12"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1103.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 6.5e-45, bitscore:
                     145.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMM
                     TFARDYLLTILSQRFTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALAS
                     TILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSN
                     AMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQ
                     LILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRL
                     NEVYLIESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVG
                     VSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLE
                     NLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARAL
                     LTKSPVLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGR
                     VVETGSHQDLMSYPGFYYQLFRK"
     CDS             complement(9797..9907)
                     /locus_tag="ctg41_13"
                     /transl_table=11
                     /translation="MTQFTTELLNFGSIISVVGKTTVEIIELFEMVPPQG"
     CDS             complement(10214..11959)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     287.7; E-value: 1.1e-87)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 313.2; E-value: 6e-95)"
                     /gene_kind="transport"
                     /locus_tag="ctg41_14"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGTLSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVAIIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNI
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLI
                     DGVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     AMEGE"
     CDS             complement(11952..13709)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 389; E-value:
                     6.4e-118)"
                     /gene_kind="transport"
                     /locus_tag="ctg41_15"
                     /transl_table=11
                     /translation="LFFKESIIAKLWWFFKLEKRRYIVGILALSLVSVLNLIPPMVMGR
                     VIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILATSYRLGQIMRSRLFEHF
                     TKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDASITALVTLITMFFSISWQ
                     MTLMAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQEA
                     ELQSFQETNKMTFEKNMHTMKYDSLFDPLVLLFVGSSYVLTLLVGAFMIQAGQITVGNL
                     VTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIETLLEQESDVQDPAYPLPSIENGRL
                     DFAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGPTGSGKTALVKLLLREHDVNQGAIYLN
                     GHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNIRFGNPDFSIDKVEEATKLAQVYDDI
                     KDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILDDSLSAVDAKTEHAIIDN
                     LKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHDDLLAQGGWYAKTYESQQL
                     EMEGGEAHA"
     CDS             complement(13897..14103)
                     /locus_tag="ctg41_16"
                     /transl_table=11
                     /translation="MRERGQVWSYSEVKRESQLANYNTDGRYLSETTNFELYNFVREYK
                     TSDEIRRIWNPKKDESVIHDKDN"
ORIGIN
        1 tgcctacatc tatttttaca atcatcaacg ttttcaagag cgcaataacg gccttgcccc
       61 tcttgaaatg aggaacaagg ccgtcgccta atattttatt atttcattgt ccacttgaca
      121 gggagctatt caatatatgt tcaagattat tttttatgtt tatttttatt gacctttttg
      181 aaaaagatat tacctaacaa agcaacaaca aaacctataa taaaatatac catagattag
      241 ctccaccagc aggttgctcc ataggcaaca gtaccacctg caccacctag aacaccacca
      301 gctagataac caggaactga gcctacaact ggtaaaacta cattacctcc aaacgctcct
      361 ccgatagctc ctccgatagc tcctccgata gctccttgaa cagtcgctcc acctgcgcct
      421 ccccagctac atccaccacc ttcaacacta gcaagtgttt cgaggtcaag ggtgttaagg
      481 ttttcaattg tttgagttgc catggcaact accccctaaa atttttatcg tgtgatctct
      541 caatcacatc tttagtatag cattcaagtg tctctatcag agctagcgtc ccaaaaagtg
      601 gctatatgtc ccgaatggta attcctaaag aacatccttc aatcattgga aatcttcctc
      661 taattttcac atatttactt aatcactttc ttattataac acttttatgc aaatatctta
      721 tagattgctt acagaataat caagcaaatg cgtttattgt ttaaaatatt ttttgacttg
      781 aaggtaagat agaaaatcac agaggattaa caaaagcatt aatacggcta gtactatacg
      841 gtctgtggta tcactgaatg ttagtaatgt gtaaaactct acactaagca ctagaaatgt
      901 gatgacagga aagacaatga aggactgccg tattgttaac agatttactg aatctggacg
      961 cttcttaagc atacggtaga gcagtccatt aacaaaaatg actacgaaag ctagtgctcc
     1021 gactgttagc caagttcctg gcgagatctt gcttttgtag agagaaaggc tgatacttat
     1081 aaggaaaact gccaacgcag cagtgatggt tctaaaagat cgcaatacac tcgaactaat
     1141 attctttaac ttcatgataa aacacctaaa ctatgaataa cctcagtcag tcttgcaaac
     1201 ctaataagct attacattta actctattcc tctctgtatt ttattataca gctgtaagat
     1261 ttcaagtaag cccttagcga ttaaattcta ctggagatgt aatacagtag tgtcattagt
     1321 actgatactt taaataggcg aatatacata tctttgtttt ctctattaca aagatatgca
     1381 atcaaatata atataatctc cgctatcatt agcaagaata attttacttc gggaacatca
     1441 aaaataagca tttgcaagca tcttacgttc aaagtgacca aaggttactt ttgaaactgt
     1501 acccactttt taaaaagtaa gctataaaga agcaccgtta gccctagcaa gttaatggta
     1561 tggtgaactg catccaagct tctaaataga ttagcgaggc ccattacgat gagaatggta
     1621 gccagtaaat acggttttga gtttttaaac atacttttct ccttaaagtg tttttagcta
     1681 gtctgtgcat aatctatgaa ttttattata gattggaagc cgataaaaaa gtagtgacat
     1741 aaatgtcact acttgtctga ccttatatcc ttgataaccg tacacataag aaagagaaat
     1801 aaacataacc cgataagatt taggcattga agtccaaaat tcagtttttc tccaaagtta
     1861 tgtaaggcaa caaggacgaa gcccatagac atcattagag acactaggcg ttttttggtc
     1921 atgattacaa ataactcttc tcttatatcg aaattttcaa tcataattca catgctattc
     1981 acagaccagc aattgacaag acatttcagt taggatttct tcttaacgga agatttcttc
     2041 ttaacggaat tggtagcctt gtgtttttca agaaatgaca taattggctt atctaaaaaa
     2101 ctcataacag ccatggaaac catccctaaa atataacttt tcaaatcaaa cataatccat
     2161 caccaccagc atgttgctcc ataaccaaca ccacctacga tagcacctcc agctgctcct
     2221 gcgacagcac cttgccaagt acgtgttttg atacctagtc gtaaaccatt accaactcct
     2281 gtagctactc cttgtttagc aaaacctccc cagctacata caccaccttc aacactagca
     2341 agtgtttcga ggtcaagggt gttaaagttt tcaattgttt gagttgccat ggcaactacc
     2401 tcctaaaatt tttatcgtgt gatctctcaa tcacatcttt agtatagcat acaagtgtct
     2461 ctatcagagc tagcgtccca aaaagtggct atatgtcccg agtagtaaaa aaagactgaa
     2521 tatcattttt gattcagtcc atgtcttatt gaaaaagctt taactaattc tttctatact
     2581 gcctatagac tccaaataaa aagaaaaaga atcctattga tgctaacaaa agttgataga
     2641 tatttcctga tgacaatagt actttgctat ataaatatat catcgcaata gtcgaaaaaa
     2701 tgattaggta tttcttcatt tgtatcacct atctcaaatg aagattattt agctgtatca
     2761 taacaaaatg ctgtgctacc gcctgcaaat ccagctcctg cacctgcgat gccaaagaaa
     2821 gctgcaccga caatcgtcat tccggtagta ccaataacac attgagcacc atagccttga
     2881 ccacttacat tagacaatgc atttgtatcc agttttttaa atctttcaag ttgtttatta
     2941 ttcataaatt cctcccatac aaattagaaa cagtataagg ctgcacctac taacacccca
     3001 ccgacagctc cccacgggcc acctactgca ccaagtcctc ctactgccag catcccctca
     3061 tcacaggaca acccaccctc aacactagca agtgtttcga ggtcgagggt gttaaagttt
     3121 tcaattgttt gagttgccat ggcaactacc tcctaaaatt tttatcgtgt gatctctcaa
     3181 tcacatcttt agtatagcat tcaagtgtct ctatcagagc tagcgtccca aaaagtggct
     3241 atatgtcccg aatggtaatt cctaatgtat attatttcta aaattcagaa aaaaaaaaaa
     3301 aaaatctcat tttatactca taaaaaattg aaaaaccgtt ttctttatgt tacaattttt
     3361 caataaacag tattcgtcat aaaagagagg actagacctt gaagatttac ctattagaag
     3421 ataattctat tcagatgggt cgcttggaag aggctgtggc acatgaactt aaacccttcg
     3481 gaaaagatct atcttgtgtc cagtcttttg acaaacctga ccagttgtta tcagctatca
     3541 cttctaatac aagcgatcag attttctttc ttgatattga aattaaaggt gaagataaga
     3601 agggacttga tatcgctaaa atcatacgtc aaaataaccc ttatgctatc attgcctttg
     3661 tcactacaca tatagagttc atgcctcaag cttttggcgt tacagcctat aaatacatca
     3721 ataaaacctt agatgaagct agctttagaa aagaaatagg ggaaaccatt gctcaagtct
     3781 tccctattaa cgcaactacc acggatgagt tttttctcta caaaacagag tctcaattaa
     3841 taaaccttcc tatggatcaa attctatacc tatccacatc agatatcaaa caccatgttc
     3901 acctccagac tatccatacc ctcatggata tccgagcaaa tctggcagac tttaaaaaga
     3961 tacacaaaaa gctctaccca tgccatcggt cctatatcgt caatacagat atgatcatct
     4021 ctgtcaacaa gaccaattat gaagctacct taattaatgg tcaagttcta ccagtatccc
     4081 gtatgaagat aggaaagatt gcacagattg ttgaggaaag aggcagatga tgttaacaac
     4141 gttatggcta ctttttctca cccttttaag tgcaggccta gaaattattc ttttccttta
     4201 tttaatggga cagaagattc gtctgaggta ttttttccta ctccttattt ttaatttagc
     4261 ctttaatttt atttataacc actcttcttg gtttatcatt aaattctggg gtgaggatat
     4321 ctactatctt ctgctctcct tccttttatc cactaagact aaaaaaccat taaaaataaa
     4381 gattttcaat ggtctcttcc ctgatatcct caacaacctt agtttaagac tgattacttt
     4441 ttttatcttt ccttttttta atattagtat caccgattat aaaagctctc tattaatatc
     4501 catcccttca tctatcgcac ctctttgtct atcatttctc tttattaaat tattcaagga
     4561 gagttttacc atacttcaaa agcagaaatc aaattctccg attcaacata ttattatagt
     4621 tgctaacttt tttatgtttg ggtacaccct actgttacag tccctcatgt atcttgaaaa
     4681 cactactcac tcttcaactt tggagcttcg aaaactctgt attgttattt cacttgtcct
     4741 cttcttcatt atgattgtct ttttagaaag aaacattcgt gaaatgattc aaggacaatt
     4801 ggacttccag aaaaatctcc agctagagaa tctctacacc tacaataaac atattgaatg
     4861 tctctacaat tctgttcgta gttttagaca cgattatagt aatctcttag tcacattacg
     4921 attggggata gataaagacg atatggatat tgtcaaagaa gtctatgata gtgtgcttca
     4981 agaatccgat aaacgattaa atacaagaaa ctttgactta gctagactcg ttaatattca
     5041 ggataatact ttgaaaagcc ttctgtccgc aaaagtttta caagcagaag aagaaggtat
     5101 tgaagctcag attagcatcc cagaacccat ccacttgatt gggatggaga ctctggactt
     5161 cattatcgtc acttctattt ttttagataa cgctattgaa ggtgccattc aaactcaaaa
     5221 ccctaaaatt actattagct tttgggaaga tcattgttca cagctattat ctattagcaa
     5281 taccataagt gaagaaaaaa cagaaactaa aaccatattt gaaagaggtg tctccaacaa
     5341 gggacgagag cgaggcattg gccttgctaa tgtcacagaa atcttagata actatatcaa
     5401 tgtaaactta gaaacacaga gtaacaattt ctcattcaca caacaattaa caataactaa
     5461 aaaggcctaa cagccttttt tctataccta aacttgagga atgttatagt cttttgttgg
     5521 aagcgttctt tgccctccga atccttttag gaaaccattt atataatcca tccacccact
     5581 tccacctacg acttgttcaa gagcgtggtt atcaagtgtt tcaaagttat taatcgtatt
     5641 gttagccatc agtaattctc ctcctattgg tcttgcaagt ttagtaactt gtctttaaag
     5701 taattgaagt aggtcttttg gtcaataacg cttgtcacac gaccttctag accgtaacgt
     5761 agattttggg cttctttttc tgaaatactt gccctagcag ttactctaaa cacattcccc
     5821 ctttctgttt ccgtggcaga attatcaata ctctcaagtt ttccaataat tgtggtaccg
     5881 tgattaccaa ccttatccaa ggtcagtcga actgactggc ctttttgcag ttttggcaca
     5941 taatccgaat tcacataata agtaatggca acttcctggg tttgagtcat atcgggataa
     6001 agctgggcca actcagttcc tgtcgcagcc atggttgctt ttttatcagc ttgactcaag
     6061 tgtaagattc catcttctgg tgactggatg agggtattag tcagaaggac atctgcctga
     6121 ttgattttac tctcggtatc ggtaatttgt gtttccactg agctcaattg ctgtcctgca
     6181 ttttgcaaga attgattttt tagagcttct tttttagtgc tatcactatt gtcataagtt
     6241 acaactgtgc ctgtcccagc cttttggatt tctagattac ctatggaagc attcaagctc
     6301 gaaatattgg tattaacttg agataggtat tggtctgtta cactggcatc cggtgtcgta
     6361 gcatactgac tgttataggc atttaaggtt gcctgatgag gattgccttc aggtaaagtc
     6421 gtttcatgat tggtaatagc ttgagagagc gcctcatact ctgagacctg agtctgcaat
     6481 tgactaatct ggttatcaat agcagaaccg gtattactcg caattgctgc ttggttatta
     6541 acctctgtat ttgttttagc cacacccaag tcaatatcct gtgcctgact taggtaggtg
     6601 ttaaaagtac tctgataacc aaactcgtct tcctgttctt ggaaaagatt ggttccctgc
     6661 gttaggctag attgcaaggt cttcaaacct gattcctgtc tttttaaaag ttctagttgc
     6721 ttttgaagcc cctctttttg cgatgcctcc atggtctctg aatactgaac taaggtgtcc
     6781 ccttttttaa caaccttatt agcaaccagt tgattatcta tgatggtatt gtcactggtt
     6841 gattggatta ctgcgataac cttggttggc tctatacttc ctctagacgt gactgtaact
     6901 tccttcttag caaaaaaagc gaaaagaaaa aggaaaataa ctaacaaaat caagggagta
     6961 atcaaaacag tagacatatt gtggtagcga cgatggtaaa actctgtgct tttaaacaac
     7021 tgtggattca tcgtgtttcc ttttcctcac tttctaaata attgataata gaaacctgga
     7081 taagacatta ggtcttgatg agaacctgtc tccactacgc gtccgtgatc aatgactacg
     7141 atacggtcgg tccgctcagc gatactaagc ctgtgtgcta caaagatgat cgttttatct
     7201 tttagtgcta ggaggttatc aataacctgc ttttctgtca aaacatccaa tccgctagtt
     7261 gcttcatcta agattagtac aggagatttc gttagtagtg cacgcgccaa agcgatacgt
     7321 tgcttttgcc ctccagacag acctgctcca tcagacagct ctgtctgaaa ccccataggc
     7381 atgttttcaa tatcttgacg aatttctgct atttcacaag ctttcaaaat atcagcttgc
     7441 gtaatacccc gtgctgcacc taaagtaaga ttttctaaaa cactaccact aaatatatag
     7501 gattgctgag ggagatagtt aatatgttga cgaagagttt tcttgtctat gcgactaata
     7561 ttttgaccat taaaatctat gtgcccctta tatggttgat aaaaattgac caacatttta
     7621 gctagagtag tcttaccaga tccactgaca ccaacaaaac tgattttttc tccttgtcta
     7681 atcgtcaaac tgacatcagt caaagtatca cgaccaaaac catatttata agataaatcc
     7741 gtaacagtga tatctccatc cgcaatgcct tcttgatagg tatcatcact ttgtccaaac
     7801 tctgattcaa tcagatagac ctcattgagc ctagtattag ctaccttagc agactgtaac
     7861 ttggtttgca ggttaatgat attttccaaa ggattcgtga agtaagaaag caacatatta
     7921 aaagtaatca attgtcctat cgaaatggta tttcccatca ccaactgagc acctgtccag
     7981 aggataagta catttaaaat aagttgagca ccttgtttca atgatgtttg tagtatagat
     8041 aacttagaaa ggcgaaaaga attgtctaga tagtcaataa actcaccatc aatcttttga
     8101 tagcatactt cttcgctggt tagtgacttt atggtttcaa tcccattaat gtcctcaatg
     8161 atggctgaat taaccatagc attactctgc atgacgtcat gattcattcg ctcaaaaggt
     8221 ttcataaagg caaagacgat aagggtataa attggaaccg aacaaagaac tagcttgaag
     8281 agattgctat tttgtatcaa taacacgcct cctacgataa tcacaataga gaaatcaagg
     8341 aaaagtgata atatcgtcga agccagagca tcgataatag agttagcatc actaaaacgt
     8401 gagataacct cccctgtacg tcttgtggca aaaaaagaca ttgggagttc aaagatatgt
     8461 cgtatgtagg acaagataac gtcaatggta aatcgctgac tcagtatggt taagagataa
     8521 tctcttgcaa aagtcatcat ttgttgtaaa acataggtca caactaatcc aattgagata
     8581 attcctaagg tagacttcat ttgattaggg acatattcgt ctagaatacc ttgtaaataa
     8641 taggaaccta aaatatttat taaagtaacc aagagactgg caaagacaat attagctatc
     8701 aaggaccttt gtttaaagat caaagggaga aagtcccaga gtccattttt cttatcctta
     8761 tgtggtttat aactgggttc cggtcccata aaaagagtaa cacctgtcca ctctttctca
     8821 aaacgctctt tagtcatttt agttactttt acacttggat cagggtctcc aattatcaga
     8881 taatccttgg tgcttttata aataacataa taatgttgaa gcttcccatc tttattaaca
     8941 tgagcaataa aaggataagg aacatcttcc atctcaaaga gcgacatttc agcctttata
     9001 gctctcgttt caaagccaat ttttttagca gcctctacaa gacctaaggc agttgtccct
     9061 tctttattgg tcttcgccaa ctcacgcaga tgtgctaatg aataatctga accatagtac
     9121 ttggccactg atgccaaggc agcaactcca caatccctca tatctatttg agggacaaaa
     9181 gtcctacgaa aacgaaacat accaaaccct ttcatcacaa attatcatat gattagtatg
     9241 tcatattttc aggataaaaa gagccagcgt cccaaaaagt tgccatacgt cccaaacggt
     9301 aagaaaaatc ttaaagtcat ctccactatt accatttaag ccgtatttgg ggtcatttag
     9361 gacaagttca ttgaaatcga tttcaaagtt atacaatagt tattagaagg aaacattcta
     9421 aaatagtcct acaagcatac gtatttgatc taaccattat tactgtgcca gccctggtat
     9481 ttccaaagga aaccatgact gctgatagcc tcggagccta tctctatcgt atgatgtcat
     9541 aatttgatta tttttattcc gaaaagggat aacattatga aaaacgtcaa tccatatctc
     9601 aaaaaatcct atcaaaaaag gctaaatcag cctcttgaga ttcgattact caattatcgg
     9661 tttaattttc cttagctttg taagtgtatt tgttatcact gtcaatgcta tttttagcgt
     9721 cactagaggg gttcccttcc ttaatgccca ccttatttcc accttgagta attgtgcctt
     9781 ctatcttttg atttactcaa ccttgaggtg gcaccatctc aaaaagctct ataatctcta
     9841 cagtggtttt tcccactaca gaaattatag agccgaagtt aagtagttct gtggtaaact
     9901 gagtcatagg aataaatctc tttctagtaa tgttttgcaa ctctactata acggatttat
     9961 tcctttttgt gtttacacaa cttattttac actacctcaa cgtttgcaag tacctcgaga
    10021 tcgagtgttt caaatgtatt atttgtttgc cttgtcattc taacaacctc ctaaattatt
    10081 tttagctttt tctctcaagc tatgatttta ttatagggtg gtagccaaca aaaaagtagt
    10141 gacataaatg tcactactcg attttgattt ttaagaaatc ttttcgaata tagaagctat
    10201 ggtctagatt agcttactct ccttccatgg cgcctgcttg taggctgtac atcttgtgat
    10261 aggtgccgcc gagggctagg agctcttcgt ggctaccatg ttcaatgatg cggcccttgt
    10321 ctaagacata gatgcagtta gcatcttgga ttgttgatag gcggtgggca atggcaatgg
    10381 ttgtacggcc ttgacgcatt tttgcaagag agttttgaac aatagcctct gtctccgaat
    10441 caatattggc tgtcgcttca tccaaaatca agattttagg ctggctagca acggttctag
    10501 caaaggctag aagctggcgt tgaccggttg agaaacttga accacgttcg gaaactgggg
    10561 aatcatagcc ttcaggaagt ttatcaataa agtgattggc atcgacaaac tcagcagcag
    10621 ctttaatctc ttcatcagtt aaatcttgat acatggcaat attggatttg attgtgccat
    10681 gatagaggaa ggggtcctga aggacaagac caatattctt gcgcagctct gcctgactat
    10741 aatcacgaat atccacaccg tctatgagaa ctcgtcctga ttggaattca tagaatcgca
    10801 tgagcacgtt gataatagag gattttccag agcctgtaga tcccacaaag gcgatggttt
    10861 cacctttatt gacagagaag gaaatattat ccaaaatctg gtgcttgcca tcataggaga
    10921 aggagacatt ctcaaagcga atattcccct cagtaacctt ggcagctgtg tctctctgtt
    10981 caggctcata ggtacgctcg tcaatcaagg caaagacccg acctgctgag accatagagg
    11041 tttgtagagt cgagaagttt tgtgtcactt caatcaaggg atcaaagagg cgattaatat
    11101 actggataaa ggcatacatg gtacctgctg tgatacccag atagatacct cggtagccaa
    11161 aataggccat gagaacagca taagccagga gcttcagtag actcatggct gggcgtagaa
    11221 agagagaatc cagtgatata gaacggctgg cataaatcag gtgttcctca ttaatggcat
    11281 caaactcttt tttaagacgc ttctcctggt taaaggcctg aatgatgtga atcccttcga
    11341 tactctctga cagtttggca tttatatctg aaagcaaggc tctggtcttt tcaatgatgg
    11401 ccactgattt tttgcgataa aggttaacca aaaggacaat cagaggaaga aagaggacaa
    11461 taagcccggt cagacgaatg tccaagatca tcatggtgta aagggtggta acaaagataa
    11521 agatagccga aataaaacta gacagagttc ctgagaacat ctcgctaatg gtctcagtat
    11581 cattggtcaa gcgggaaacg atggaacctg ctggggtctt gtcaaagtaa gacataccca
    11641 gtttttccat attggcaaag gcatctcgac gaatatctct gacaatgcta taggacacac
    11701 gcgcaaagaa gagatttccc agatactgga ctagtgtctg caagaggtag agaccatagt
    11761 agccaatcag aatcatactt gccgcctgat tcatatcatg aagatagtga tcaataaaat
    11821 aagaggccac caagggaatg atactcttga taaccgttgt ggacaagagg aaggtcaaag
    11881 ctagaaaggt caagaacttg taaggcttga gataggtcaa gagacgctta aacacagacc
    11941 attggttttg attaggcatg agcttctcct ccttccattt ctaactgttg agactcatag
    12001 gtcttggcat accaaccacc ttgagctagt aagtcgtcat gacgcccacg ttcaatgata
    12061 cgaccatctt gcatgaccag gatgaggtca gcgtgcacca ccgcactgag acggtgggcg
    12121 gtaataatag ttgttttgtc cttgcgagta tgcttaagat tatcaataat ggcatgttct
    12181 gtcttagcat caaccgcaga taaggagtca tccaaaatca aaatttctgg attcaaaatc
    12241 atggcccggc tcatagccag acgttgtttt tgaccacctg ataggctgac acccttttca
    12301 ccaatgattg tttcaaagcc ttcaggcata tccttgatat catcataaac ttgagctaac
    12361 ttagtcgctt cttccacctt atcaatggag aaatctggat taccaaagcg gatattgtct
    12421 aaaatagaac tggcaaagag aaactggtct tgaggaacat aaccaatcaa gctacgcaag
    12481 tctgataggc gatagtctcg gatgtcatgt ccattcaaat agatggctcc ttgattgaca
    12541 tcgtgctccc gcaagagcaa cttgacaaga gccgtctttc ctgagccagt cggtccaacc
    12601 aaaccaaggg tttgcccctt gtccaaggtg aaatgaatat ctcgcaaagt atcctcatcc
    12661 tcaaaagcaa agcggtcaat cgcaaagtct aaacgaccat tttcaatgct tggaagagga
    12721 taagcgggat cttgaacatc tgattcctgc tctaaaagag tctcgatacg ttggtaggac
    12781 acatttcccc tctgcgtgat attaaagagg aagccaatgg ccattagggg ccaaaccagc
    12841 atgtccaaat aggtaataaa ggttaccaaa tttccgaccg ttatctgacc ggcctgaatc
    12901 ataaaggccc cgacaaggag ggtcaaaaca taagatgagc caacaaagag caagaccaaa
    12961 ggatcaaaaa ggctgtcata cttcatggta tgcatattct tttcaaaagt catcttattg
    13021 gtctcttgga aggactggag ctcagcctcc tgatagccaa aagacttggt taccttgata
    13081 cctgacaccg attcttgtac cttattatta agttcagaaa aagctgcctg ggattctcca
    13141 aaagctttgt gggtcttacg tcccaaacga ctagtcgcaa aagccatgaa aggtagaggt
    13201 aagactgcca tcagggtcat ctgccaggaa atgctgaaga acatggtgat taaagtcacc
    13261 aaggctgtga tagacgcatc cacggctgac atgacacccc caccagccaa acgggttaga
    13321 gagttgatat cattggtggc atgggccatg agatcaccag ttcggtactt ttggtaaaaa
    13381 gaaggcgaca tcttggtaaa atgctcaaaa agccgcgaac gcataatctg tcccaagcga
    13441 taagacgttg ccaagatata catccgccaa acatagcgca aatagtacat tcctaaagcc
    13501 gccaaaagca aataaacgag attcaaaagc aagatctgat tggtcaattt tcccgatgtg
    13561 atagcatcaa tgacccgacc cataaccata ggaggaatca gattgagaac cgaaaccaaa
    13621 ctcagtgcca gtatcccgac aatataacgg cgtttttcta acttgaaaaa ccaccaaagt
    13681 tttgcaatga ttgattcttt aaaaaacaag ttattccccc tatccctaca aaaggatgat
    13741 tataagtcta atgaaagtta tttccaatag cgataaattg taccatcttc taactgaaag
    13801 tgaccaatat aagtcaattt tccaaaatca gtagactctg gcaattgata agcaaaggag
    13861 tcaaaattat agaccttgtg cccatcatca atagaatcag ttatccttat cgtggataac
    13921 tgattcgtcc ttcttagggt tccaaatacg tctgatttca tcagatgtct tatactctct
    13981 gacaaaattg tacaattcga agttagttgt ctcactgaga tagcgaccat cagtgttgta
    14041 gttagctaat tgagactctc ttttaacctc agaatagctc caaacctgac ctctttctcg
    14101 cataatatcg gcatcacggc cacttttgat aagtatctgc tttaaccgct gtcattgttg
    14161 ctcctagtgt caatacagtg actactgtca cattaagtgt
//
