LOCUS       c00018_JAHBRL0..       17082 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHBRL010000025.1 Streptococcus thermophilus strain Rico65
            Contig_25, whole genome shotgun sequence.
ACCESSION   JAHBRL010000025
VERSION     JAHBRL010000025
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:24:52
            Original ID  :: JAHBRL010000025.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17082
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17082
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4657:7082]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4658..7082
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17082
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17082
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             206..319
                     /locus_tag="ctg18_1"
                     /transl_table=11
                     /translation="MPTKIWLKPEQLDLYIKHLERFRDLYSKLDCSGIVNL"
     CDS             548..649
                     /locus_tag="ctg18_2"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             819..1088
                     /locus_tag="ctg18_3"
                     /transl_table=11
                     /translation="VQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             1248..1547
                     /locus_tag="ctg18_4"
                     /transl_table=11
                     /translation="LCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1647..2558)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_5"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2788..2877)
                     /locus_tag="ctg18_6"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2874..3476)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_7"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.5e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALELDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3570..4661)
                     /locus_tag="ctg18_8"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4658..5977)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_9"
                     /sec_met_domain="PF04055 (E-value: 5e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.8e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.4e-13, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 1e-24, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(6047..6139)
                     /locus_tag="ctg18_10"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6222..7082)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_11"
                     /sec_met_domain="TIGR01716 (E-value: 5.1e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7322..8134)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.8; E-value: 2.9e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg18_12"
                     /transl_table=11
                     /translation="MLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIFTEHKGNYG
                     YRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAENLIQRQFE
                     ASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQVKAMLEQAF
                     TEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESFFGILKSEM
                     FYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8152..8718)
                     /locus_tag="ctg18_13"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(8897..9055)
                     /locus_tag="ctg18_14"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9067..9198)
                     /locus_tag="ctg18_15"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             complement(9208..9720)
                     /locus_tag="ctg18_16"
                     /transl_table=11
                     /translation="LAAAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQ
                     PYMTESAYSQELTSQNDAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSD
                     LKNANQSKTNQTETRTVNLNYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPS
                     LPNTTTK"
     CDS             complement(10120..13299)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 498.4; E-value: 7.8e-151)"
                     /gene_kind="other"
                     /locus_tag="ctg18_17"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDHFQKSLEERLRQSNKDMEKRQAQLDGHFASQVWSE
                     EELSVLEQTPASEKLTRLEEFLSQRQENVTKQKSILKAAHEDLAQLQKSLQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELTVQSKDFLQKEEELETWKENIIYAQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLDSLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLIIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVAKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQSIPMLQAKLTTYATLKQELQAQIHKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13296..14504)
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.5; E-value: 8.1e-77)"
                     /gene_kind="other"
                     /locus_tag="ctg18_18"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMEKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 tgacttaagg ttaaaagata tggcagacaa agtttatcag ataattgacg gtaaaatgac
       61 aatcctggag aagtaattta atttatgact aaaaatcagc aaaaatataa ttatgactaa
      121 ggaatatttt attaactaaa tgttgagata gcacaaggaa atatttgtgc tatctttttt
      181 atttattagg aaaagagaaa aaattatgcc aacgaaaata tggttaaaac cagaacaatt
      241 agatttgtat attaaacatt tagaacgatt tagagactta tatagtaaac tagactgttc
      301 tggtatagta aatttgtaac actcctacct aataagttaa actattcatt agaataggag
      361 acataacatg aaacactatc cagacgaaac acgataaaaa attgttcgac tgcacattca
      421 agacggatga acattaaaaa gcttagctgc tgaatatggc gtatcccaag cctcaatctc
      481 taattgggta agacattatc gcaaagaatg ccaaactaat aataaagaaa aatcacagct
      541 tgaactcatg gaggaggttc gtaaattacg tcaagaaaag gcagagcttg aaaaggaaaa
      601 tgatttctta aaaaaagcag cggcattctt tgcaaaggaa atcgattaga ggcatatcgt
      661 tttattgata actataaaga agattttggt ttgcgttggt tgttcttgca tatgaatatt
      721 catcccaatg cttattataa ttatcttaaa aagacaagga ctaactatca tcgtcaaaag
      781 aaagctattc ttaatactat tcgagatatc taccatgagt gcaatggaaa gaagtaaatc
      841 aattcttcga aacagaaagc atcaaacttt ctgatataga gccttcgaaa gttagttata
      901 gggaggtaca aaggaatcaa atcaatacca ctatttataa tgaaaaaggt aatataaagg
      961 atattgatac tagcattata agagatatgt acgataaaag caaacctact ttaaaacagg
     1021 gagcctatat atccgctata gcagcttctc tagaaggggg gtactgcatt tataacagca
     1081 ataattaaaa aaagcgctta gggaaaacta ttagtgagtt tacaaaagac gattgtcttg
     1141 aaatttctaa agatagtgga attggagcta taaaaggaag tactcgaggc attacgatat
     1201 acgccctaac gaattacaca gctactcctg cagcagtagc aagttcattg tgcactgctt
     1261 catttggtat cgctaaagaa gcatacaaat tccgtaaaaa cttaatcaca aaagaagaat
     1321 ttttactaaa ttcgcaaata ttatgtgttg aagtatcagt tagtgcatta tcctcaatat
     1381 taggacatgc tgtaattcca atacctattt taggatccgt tattggaaat aatataggaa
     1441 ctttcctata tgaaatcgct aaagataatc tcacaatgaa agagaaatta ctgatagcag
     1501 attatttcaa agagatacaa gaatataact attttttaga taattaattt gaattatata
     1561 atcatcaact tcagagagat taagaattac tataaacttt tagggaaggc attttctcct
     1621 gactataata tcgcttttca gggatcttat gaatttttaa atatgttttt taaaaatacg
     1681 ttaacctctc ctattttctc tgcttcaggt aaatagatag aaacggttgt cgaataaaca
     1741 aaagaaggta cactcacaat tgaaagcaat tgactaataa ctgcataaat agccaacaat
     1801 tctactccta atctcgacat caaggcatca aacaccataa taaacaaaac actctccaga
     1861 atttcttgac caaccaaagg aataccaaat gttattaatt caaatttagt tgtagatgta
     1921 atggataaag ccttcaaaat cattggataa accataaaca agtaactaag cgatatgaaa
     1981 gctaaggata caatcgttga tatggctgct cccttaattc cgatttgtgg taccagtaca
     2041 taatttaaca caacatctat taatgaactg ataagtccaa cccacataat tggttttgtt
     2101 ttcttttgaa ctcttaataa atttgtcagc gaaaagttta ataatgtcaa tccgatatat
     2161 ggagacatga agactaaata aatggtggat aaggacaata gttgcccttt aaatccatag
     2221 agctgcttca agattacatt tccaaaaata atgacaaaaa ccgcaaaggc aactccgata
     2281 attaaatcta aggttagatt tgatttcaat aaatcatcaa acctgttagt ttgccgatta
     2341 gagtacgcct tagagctttt aatattaaat gacaaactga atgctcctaa aagtccacca
     2401 aaagcaaata agagattctg aataatggaa attcctgaca gagcaattga ggaattgttc
     2461 acagcaaaat gcaatgctat ctgcccaata attacttgac caatatttgt taaaactaag
     2521 ggaaaggcaa atttgttaat ttcttttgaa tctatcattt ttcctctcta aaaggcttca
     2581 aatgtaagta aagatcagat ttaactaaat ttgcataaat aatatgcaaa ataggagttt
     2641 cttctaaaaa tgaaataatt gcctgcttac aatcattagc agatacctca taatcttgct
     2701 gtaatagttc tacaatcttg tctaaagaaa aatttttaga aatgcaataa agtatttctg
     2761 ctcctatttc atcaaatgaa tagtactcta atcaagtaga tcgtatccta tgtattcatc
     2821 tgctacttta tttacaatga aatctctctt acctcttatc acaaaatgtt ctttcatacg
     2881 actactccac ctcctttttg ttcataaaag caggctaaat cagagcccag taacgttcca
     2941 tctaattcca aggcactgca tcgacatccc ccaccacacc atggtagggg acattctgaa
     3001 catttcccag aaatatcatc aaatgtaatt gatcttagtt tattaaatac agcagaatgg
     3061 tgccaaattt cgctaaactt ttgttcttta acatttccag caactaattc atctatacca
     3121 ttcatcaagt cacacccgta tacatctcct ttatgattaa ttgaacatgc tctaactcca
     3181 gcttgacaag atatttccct tggcttatca aaatttatat ctactttttg atgccaaaca
     3241 ttttctaata aatctgatct attataaaat gcaagcggaa aataatgtgt caaaaaaaca
     3301 tcactttcat taggaggaac aattttaaat ttaactttga actctccttt agaaatccgc
     3361 tctgttaaat caagaaaaac aggataccat tgttttttat ctgctaaaat actaccgtca
     3421 ttagccctac cagtaggaca aataaccata actgacatat actcaatacc aagcatatca
     3481 ttcaatctta tactctaaag aaaatatctg ctaaatttgc aaacaattgt gctatcaata
     3541 atttggcaaa tgaattagaa atacaacttt taagttcttt tctctctgtt agaaaatgaa
     3601 taagatacta agcaacaaag agctactata ccaaatatta aataattgct cctaatacta
     3661 aagttatcag caaaaatacc agctaggaaa tcagctaaca taaaactaat cgaaataaac
     3721 aaattatata ctgaccatga tactgctcta tttttttcta ttgacatatt aaatttataa
     3781 taaaaatgat tattgtagtt ggaattaaga acacgcatta ataaaaggat tataatttgg
     3841 atgattagat tagtttgaaa aaacatgagt atagctaata ctggtaacat caagcttact
     3901 tcaaacttaa tttttagata actccccaaa gccatagata tattaaacat aaatagtata
     3961 attcccagca tatctagtga aagtccctgt tcatttaaga atatccctgc ataagaattg
     4021 ctaatcataa ttagagttga gaatgctact cctaatatta ttaataacca tggaatattt
     4081 tgaatattat cgaggctaaa aaatttttgt ttattatttt gttccttttt aatctcgggt
     4141 aatcctatta aatataataa actgaaaatt acaaatacaa tggatataat aataggataa
     4201 atataattcc tatgcaataa aggtggagat ataatcgtaa taatagcaat aaaaatatat
     4261 tttaatgtgt tgagattttt caaaaatgat ttatatacaa cttcgtcatc aattatttca
     4321 aaattataag aaataagaac tcctgaagat aatgattctg acaatccaaa aaatatcgct
     4381 gaaatatata ttatatttga ttttccaaac aataggcccc ataatgctaa aattaataat
     4441 aaatttgaaa tagccaaaat tttcttgtaa ccaatcttac ttgaaatata acttaaagga
     4501 atatcaaaaa ctgagccaca tagctcagta ataactgata aagtagctat ttctgtgaac
     4561 gaaaaaccta agtgctttaa tagtaaaatt cctacaaagt agtacggtaa tccagataga
     4621 aacatattca ttccgtataa attaaaaatc ttcttactca taagttacaa actgggtctc
     4681 taaaatattt tggactcttc tccttaatca agttaacata gcagccaccc tcgcaaattt
     4741 ttaacaatcc acaagataaa cacttagaat tcttcgttct aaaagaacga atccctccat
     4801 acaacggatc atcataccaa acatctaaca aatctttttc aaaggcattc tgcttagttt
     4861 gattaactcc taaaaaagca atgcaaggca agatatcccc attagacatt atttccatct
     4921 tagtatattt tgcacgacat ccataataca tttcgccaaa ctctgaaaat tcaattgaat
     4981 tatttatcaa ctccggataa gcggtgaaaa gatgacatcc ctcagtagca aaatttaaat
     5041 tagcttcccg ttgagttata taatctgtaa catactcatt caaccttctc aaatcagcta
     5101 aatcgtattt tttctttatt ttcgtatatc ctgttacctc agaataatta gctactgaaa
     5161 atctatctat tttattctct atacaaaaat caaccaattc tataatctgc tcatagcttt
     5221 gctttgtata cactgcatta attctacatt tttttccaac ctctttaaag tacttcgcta
     5281 atttaatttg tctatcaggt ctcaccccca ttaattcaaa atttaattta ggatctaaag
     5341 tctgcaaaga taaaaccggt gtaatatatt tagatttagc tagaatttcc actgtacttt
     5401 tctttattaa ttgggcatta gttgttatag tagtctttat cttcagttct tcacaagcta
     5461 tcaacaaatt atcaatatca aaatatctag tcggttcccc tcctaaaatt gaaacactta
     5521 acactccatt atcttttgct tggcgcaaaa ttctttccca atctttagca ggtttggcat
     5581 ttctatcttc acgatttgct aaaaaacaaa aaccacattt taaatcacag tacatactgg
     5641 ggtatattac tagttcaagc ggaaaactca atatgttatg tttttttaat tttgctacat
     5701 gctttctcgc attttgaaga gtctcgtcag gatttttcga tgatccctca atattattat
     5761 cagaatagat atttaataag agtactcgct ctagtttccc tgcttttatt tctttcttaa
     5821 aaaaggacgt agcaatttca aaaccatgat tttgaaccaa ataaagaaaa taagcttcac
     5881 tctcatctaa ctcaattcgg tcaaaagtta ctttatttat caaaattcca ccaaactttt
     5941 ctagtctaaa taaaaaatct tctgaaattg tcatcatatt gaataccttt ctaaaaaagc
     6001 agaggaaaat atagcctctg cttaacttat gggataaatt actttatcac tcccagccgt
     6061 caccttttgc catcaccttc cagccgtcac cttttgccat tgaactagac tcaaggactt
     6121 tttcaagctc tttagacata tttggtactc ctttcgaata tgatactgtg attatatttc
     6181 ttttcaacac ttacaataaa atattcccat atttgcattt tctaactact agctaaaatt
     6241 ttttctaaat gtccttcata agtctttgct aagtgatgac ttcctgctaa tttcatcgct
     6301 ccaacacact tcttcatttc aataattgct ttcacatttc catcctcttt atattgataa
     6361 agattttgtg catacttaaa gactaaacgt tcatatactt ctgtctcaat aaaaaagcat
     6421 tgatttagct gcttttcaaa atataaagca tccataaatt tttctctttc aacacatgta
     6481 atatatccat ttaaaagcat cgttgaaatt aatcgtctgt tatttggaat ttctttgtaa
     6541 aaatcagaac gcctaaacat ttctcttgct aagaccatga aaacatcatg atttaataca
     6601 tctaaagtat tcgagaaaat caataactca tagtaccccc agtattctac actaaagaga
     6661 taatctgtta aatatgtcaa atcatccttt gtatagtaag tttctcctga taaatcctgt
     6721 agacgaattt tcaataaaat aatattgatt tgatgaaatt tttctcgcct atcttccagt
     6781 tccatctgag aataaagtaa ttttttcata ccttctacgt cacgtgttga cacaaaatga
     6841 cgtactttcg ataacagttc gtttaactca tctctatgaa aatcatggac cgcatacata
     6901 aattcatcta ttggcatatt gatttcatct aaaataaaca tgaactttga aatcgttaaa
     6961 tctgtttctc ctttctcaaa tcgagagagc tgagacgttg atataccagc ctttgcgacg
     7021 tcttttaatc gtaatcctct cgattctcga aactttttaa aaatttctcc aaattttttc
     7081 atactacacc tccatcacgc atatatggga ataattttca tttgctttca tcatatcata
     7141 caataaagaa aaacaaaagt gaggattatc acatgaaaaa gcaaatttta ctaacacttc
     7201 ttcttgtcgt atttgaaggc attatcgtta tcgtcgtggg ataaagagtc tgggacaaaa
     7261 gtcctttagc tccaaaaagc aacggcataa tgtactgacc ccaaaaagtt agacaaataa
     7321 tttaagtaaa ggatttagtt ctgtattgta caggactgag tccttttagt tttaccttaa
     7381 tgcgtttgtt gttgtaataa ttaatatagt ctgcaattgc ttgttccaaa tgctcaattg
     7441 acttaaacgt cttctcataa ccataaaaca tctcagactt aagaatgcca aagaaggatt
     7501 ccatcatgcc gttgtctgga ctattgcctt tacgtgacat ggatggttgg attcctttct
     7561 cctctaaaaa atgatgatag aaatcatgtt gatattgcca tccctggtca ctatggagaa
     7621 ttgtattttt gtaatgtttc tctgtaaagg cttgttctaa catagctttc acttgtatca
     7681 agttcggtga cttagaaaga ttgtaggcga taatttcact attgaagcca tctaaaattg
     7741 gcgacaaata gagtttttgg ctgcttgctg gaatggcaaa ttctgttaca tctgtgtagc
     7801 atttttccaa tggtttggat gcttcgaact ggcgttggat gagattctct gctttcatac
     7861 caacctctcc ttgatatgaa gaatacttac gtttacggcg aattctagcg gttaaaccaa
     7921 gtactttcat aagacgttga actctcttat gattaatcac aattcctcga tttctcaatt
     7981 caagagtcat tcgacgatag ccgtaatttc ctttatgctc agtaaaaatg gcttgaattt
     8041 cagctttaat gtcataatcc ttatcatttt gatccagctg ttttaagtgg taataatagg
     8101 ttgaacgagc aagcttaata atctttagaa gcatatctaa agaaaactca gttaccaatc
     8161 ctcggacaat ttccgttttt cttcttgctc tttttcttcc ctcaatcgga gttctctcaa
     8221 ctttttaaga actgcattct ccgctctaag gtactcattt tctgcttgaa gacgttccat
     8281 ttcttccagt tttttctttg gcttacgtcc cattttagat aaccttcctc ttgttttctc
     8341 aacaatagta tacccgtttt tcttatagtg tgcgagccag ttaggaagcg tcccacgatt
     8401 tgggagagca tattcaagag aaactctatc ttgagaatag cctttatata ggactttatc
     8461 aatcatttct tgttttaatt caggagagta gtaacgattc tttccttttt tagcgatttc
     8521 tattccgtat cgatcaatca atttaatcat gtagctaaga ttagaaatgt ttatcccaaa
     8581 tttatttgaa agctgatcta agctatatcc ttggtttcta agttcataga tttgaacctt
     8641 atcttcataa gtcaatttca taataaaaac accccgaaag ttagattttt tctgtctaac
     8701 ttttggggtg cagttcataa aaccgttgct ttttgcatga ttgtgataga cttggtgaaa
     8761 tagaattgac caaaaatctt ctgaaatata acaagagagt gactcgaatt taaaaagcta
     8821 gagttccaca attggaaatc tctagctttt ttgtgactga gaactttttg tcccagcctc
     8881 tactttctac tgactactat cctgcatgcc ctaagtcgag atagagaata tctcgcttag
     8941 tggcatactc tagcgcatgt tcaacagcct caaataaatc tgaagctaga aaccttttcg
     9001 taaagacggt ttcgtcttta cgcttaaatt tcgcaacata actatgttta gtcatttttt
     9061 ctccttctaa tattcatatt gtcctttaac accactatag atccagtaaa ctgctttatc
     9121 ataaacttgt ttaaaggaga tacctaatcg attggctaca tcaagaattg aaatttgctt
     9181 acattcctct atattcataa aatatcatca ttttgtcgta gtattcggca atgatggaac
     9241 agatgaggat tcttctaaag ttttaggagt tgccttatct agatcatcta acccagattt
     9301 ccaaacctgt acttggttga ccaataactt accaggtagt ttcgaatagt tcaaattaac
     9361 cgttctggtt tctgtttggt ttgtctttga ttggttggca ttctttaaat cagatacata
     9421 agttacatta taagagacca tggcaatggc ttgattcgta gtctgattga caaagatatc
     9481 tgctttttca aaatgataat ccaaaatata gtccttatac acttggttca tggcatcatt
     9541 ttgacttgtc aattcttgag aataggccga ttcagtcata taaggttgaa tacgtgtatt
     9601 attttcccct agtttttctt tcgtatagta ctgtgtcaaa aattctttta cagtatctga
     9661 tgataaaata cttgctttat cttctgcttg tttgtcctct acaagtttag ctgcagccaa
     9721 ttcgatttct tttcgacttt gtttggcagt agaatgttga ccaatagaat tagcagtaag
     9781 ttgtggtgtt gatgaggtgg atatactaaa aaatgaggag gaaattgata attacttcac
     9841 ctagctaaaa gttcaacgaa ttagggagac attaggtagc ctcatattac tttgattagt
     9901 ttttgctata acattgtcaa atatgatgac aaaaaaatcc gtccgcactt ttttacgagt
     9961 aggacgaatt aaatatgtta tacaaaccat cagcttttta acaattctac ataaggtagt
    10021 tgttgatgca actacctttt ttctatgctg attagaacaa atttgacatg gctacaactg
    10081 cgattatctg atatagagta ttatataaac tgattcctcc taccccttat ccacaatttt
    10141 aatacggcta ctgccatcgt gcgacttgat gataactagt tgctgagcaa taccttcttt
    10201 catatcgtct acgtggctga tgacaccgac catgcggttt tcaccgattt gttccagaac
    10261 agaaatggcc ttggtcaggg cttccttatc cagtgagcca aacccttcat cgatgaagag
    10321 agcttcaaca acggcaccct tgctggtatt ttggacaact tctgagaggg atagggcaat
    10381 ggccagtgca gcgataaagg tttcaccacc agacaaggat ttaacggagc gttcactacc
    10441 tgtcagctgg tcatagacgt tgatatccaa accgaagtga tcacgcgccc tgcgtccttc
    10501 ctcacttaga acaaaggaat agcggttatc cgttaatagt ccgatgtagt tagcattggc
    10561 atagtccaag atttgttgga aatactgacg gataacgtag acctcaagat taagacgacc
    10621 agttagagca gtattttctc ccttaaccac cttaaccaaa tcactgagtt cttggtgggc
    10681 cttaaaggcc tcttggttac tgtcttgaag ggttttagcc gcttggtagg tagccgtcgc
    10741 atccttaagt cccttttcca tgacagaaaa ctgagcgagc tgcctatcat agatttcctg
    10801 acaattctgt actgcttgcg ctagactatc gagatctggt tgttcttgat tttggagaag
    10861 ctcttgcccc ttatgaatct gcgcctgtaa ttcttgtttg agcgttgcat aggtcgttaa
    10921 tttggcctga agcataggaa tagattgatt atttacctca ataagccaga gttcgacctg
    10981 ctctaagtca ttagcgaggg ctccttcagc cttgagactt tgctctaatt cagcagataa
    11041 tcgcttaaca tcttgattta ccttatcttt agacttagtt atactctcaa tctgcccctt
    11101 tattccttta atgtcggcat gaagttggtt gtaggcttcg ctattttcct tgacttgctt
    11161 attgtagagg ttcagctcct gatgagcaag ggaaatccgt tcttgatata cctcaacaga
    11221 ctcaagttct ggatgagctt cctgcaggtc ctctaggcgt tcttgagctt ggtcaagcac
    11281 tgccttggcc tcttgatagg ttttagccaa atctgtcgct tttttttgag ccttacctag
    11341 ctcatcttga tatcggatat aatctgtctc ttccttatca taacgttttt gtaactcttg
    11401 ataatactgc tcaaccttca ggagtagggc ttgcccacgg tcagtttcat agtctatcga
    11461 aaaatcaaaa tcaaaccgtc ccttaacgtg ctcttctaat tcttgatagt gcttttcaag
    11521 agttgccttg actttagcca cttggtcaag caaatcctga cgtttagatg caacttcact
    11581 caaggtagcc tgacgatttg ataaagtagc gacttgcttt tctttttgag cttgaagctt
    11641 ctccacctga tccatgagat ttttcaaggc cacttcatca gcctgtgctc caccaacatt
    11701 agggtgttcc agagcaccac aaaccataca aggatgcccc tcctctaact ctgcctgcag
    11761 ttggacaata atgagttgac ggcgtgaaac caaagtcctt cttaactcct cttccaattc
    11821 tttgagaatt tcttgagctt gatcaatatc aaaagataac gtttgatgac gtttttcggt
    11881 ctttgtcaac tcctgattca agttctctat ttctttcagg tcctgagcaa gttgattctc
    11941 cacactgtag cccacaatct ggaagagttt ttcggcctca tgtaaactat ctaaactaag
    12001 acgattagcc tccaagtcag acaaggactt gttaagcatc tcaacctctt ttctagcctg
    12061 ctgataggtc tcttccaact gcttgtagtt agtcgttgaa cgtttgattt tctcctgttc
    12121 ttgggcaaga ctctgggcat agataatatt ctctttccaa gtttcaagct cctcttcttt
    12181 ttgaagaaaa tccttagatt gaactgtgag ttcctctttt ttagccttaa catcctcaaa
    12241 cgcctgttgc ttttcactta aggcttcttg agcaatttca aggtcctgct ctaattgcat
    12301 caactgtttc cgatactgct tcaaggtccg aatggtttcc tgcagacctt gagcaaactg
    12361 taattcctcc agatgcactt ttgcctctgc ctgtccttga gccccctcct caatttccag
    12421 acggtaacgt tccttggctt gctccaattc ttgaaaaatc tttgccaaat cttgggcagt
    12481 ttgcaagctc ttctgcagtt gtgccaaatc ctcgtgggca gccttcaaga tacttttttg
    12541 cttcgtaaca ttttcttgac gctgagacaa aaactcttca agacgtgtca atttttcaga
    12601 ggctggcgtt tgctccaaga cggataattc ttcctcagac caaacctgac tggcaaaatg
    12661 accatctagc tgagcctgac gcttttccat atccttatta ctctgacgaa gacgctcttc
    12721 caagctcttt tgaaaatggt caaaaatacc cgttccaaag attttcttta aaatttgagt
    12781 cttggtctta gaatcttctt tcaagaaacg gctgaaatca ttttgtggaa ggagaataat
    12841 ctgtttgaac tgctcagcat tgagccccaa aatctgctca atctggtcac tcacttcctt
    12901 gatcttatcc ccaagctttt caatttcctg accaccaatc ttatccacaa tgactagaga
    12961 agccgtcgcc ttttgcatgg tagtgccccc accctgcttg gccctctctt gctggagaac
    13021 tcggtcaatg cgataaaggt gattgccttg ttggaaatag aaagtcacct tggtcaaatc
    13081 atcctctgga ccagcgaaag ttgaccgcat ctcctcaaca ttacgatcac cactggtcgt
    13141 agcaaacaag gctaccgtca tggcatcaaa gagagtactc ttaccagccc ctgtatcccc
    13201 tccaatcaaa aagaggggag catggtcaaa ctgagtgaaa ttaataactt ccttacgata
    13261 tggtccaaaa ttggtcaatt ctaactggac tggtctcatt gtcgactcct ctcaatctcc
    13321 tcaaaaacac tttccacaag ggcagtctgt ctctcagata agacatcgcc cccagttact
    13381 gtctggtaaa aatcaaatac gatttcctgg ggcgactgca tttccaaatc ttttaagtgc
    13441 tgatcaacgg tcaagttttc ttccctaaca tcacccagac gactgaaagt aatttctaca
    13501 atgtctgtcc cataaatctc ttccagtcgg gcacgcacat tgataccctc taattcctta
    13561 cgactagaca gttgaatatc aaaggcgaac caggcttttt gacaaggttg attcttataa
    13621 aattcaggtg acatcaaggt ttcaaaagat tcctgtaaag ccacaatcgg ccgtttaacc
    13681 tctagagtat ggaaggtctg agacatatca ccagacgcat ccaattcaag aatatagaca
    13741 cccttttctt ccttacgctt ggcttctttg acattaaagg cgactggact gcctgaatat
    13801 tgcacgcgct tggtaggact agcaaaacgc gtatggatat gccctaaggc aacataatcg
    13861 aaagacttga aaaggtcact ggtcacattg gtaagaccac ctaccgtatt actggtttca
    13921 gacaacatca attctcgaag accctgacca tcgctatcat ccttcttaga aaccgcaaaa
    13981 tgcgtcacca agacatgagc tttgtcagga tcaaaagctt tttccatatc ctcaagaatg
    14041 taggtcaagg catcaccaat cccctgaatt tcctttccct catcatcctt atagtaaata
    14101 cgagcatcaa taggatcgat aaaaggcagc agaaaaatct ggcaattctc caactcaatg
    14161 ggctcaaaag cctcctccaa acgtgtactt aaatgaaggc cctgatgttg aaagaagtca
    14221 cgcccaaaat gtaaacgttc agccccatcg tgattaccac taatcgcata gacaggaatc
    14281 tgctcctcca gtaccaagcg ggccaaggtc ttattaaaaa gcttaatcgc atccacaggg
    14341 ggcaccgcac ggtcatagag gtccccagaa atgataaccc catccacttt ttcgctaata
    14401 gccaaatcca caatttgttg aaaagcccac tcctgctcct ccaacaaaga ccagccattg
    14461 agggttcgtc ctacatgcca atctgacgta tgtaaaaact tcatgacaac ctcctcattc
    14521 attttgtctt acttctattg taccttatca agctaaatac tgcttaaaag tttcacaggc
    14581 tttgatagtt ttcccgtttt ttagctgtaa agatcaaaaa atctctccca agctatcctg
    14641 tactgacccc aaaaagttag acaatttatg taagcaaagg atttagctct gtattgcaca
    14701 ggattgagtc cttttagttt taccttaatg catttgttgt tgtagtaatc aatatagtct
    14761 agattaccct gcctcaattg gttaagtaat ttaaatacct ctaaccaaga aaatcaatat
    14821 tatctattct tttaattgac ttttatagat tctaagcatt atcatatagg ttggtactag
    14881 tgcacatctt gtattttagg caataatatt tactcacttt tcgttattgt cagtaccgat
    14941 cctttttaaa tttttcacca tgaaaaccta aaaataatcc gaaccctaag ggctcctgac
    15001 tttttacttt attctaggct ttttttatcc gtagcttgtt agctgacttg gaactaggca
    15061 tgtagtattt actatttccc tacttgagat tttttataag tcacatgcat tattccatct
    15121 gaacgaatgg tatgattttt atttctttta gagaaacacc ggtaatagct aattcctatc
    15181 ttaaatcact tgaaatatat ttataatgtg ttggagtgct aatcagtacc gcttgtagat
    15241 ttttggaaga tactaacaca ctaatgattt aatctccttt aaaacatgaa aagagaagcc
    15301 tccaaagctt ctcttttata attatcaaat aatgtacaac tagattctta ataactacct
    15361 aatttagtgg ttcaatcatg aagcttaatt gatagctatc tgctgagcta agcaagaatt
    15421 cgtcatgaac tggagcaccc catgtgtcgt caccacctac acccatttga gcagcaagaa
    15481 ctttaatcca tgtagcatca gattcttgca actcatattg gtgacgagca ttttcaattt
    15541 gttcagtact gttacgcaaa gcactgaatt cgaatgcttt attaagtgcg gtgaatttaa
    15601 gaccattatg gttatcatca gatactgtga attcacgagt accatagtga ttaccagatt
    15661 cttgtggcat tagatatgga gcaaatgtct tttcaacaga tgtttcatat cgaccaagat
    15721 aggcaccagg aagtttatca cggtagcttt cttctgcacc gtatccataa tagctaaggt
    15781 ttgtaaattg tgaaccgata gcaaattcta gaccaaattc agggaagttt ggcaaacctg
    15841 ctttaccatc atagtttgca gtaacaaaga ttcgaccctt gtagtcaact tgataagtta
    15901 ccttaacttc gacatcagac aagcctggca attcatgaac ataagtcact ttaacagagt
    15961 cgtcttcgat ttgaatttga gtatctgtaa ctttactata gtttccagca accttccagc
    16021 ctgccatttc gaatggatat ccagcaccac gatcgttgtc agtgtaagca cgagtgaagc
    16081 taagtttagg acctttctca atgaattcaa caccattata cttagcagat actaaagtat
    16141 tttgtgcacg tgaaagcaag attgagaagt tttgtccttg aataccgatg ttgaagtcgc
    16201 cttcaacaac attcaaaggt gctttaactg gtgtttcagt gctaatcttt tcaacaacat
    16261 attgaccacg aacaatttca tgacctttag gagcccattc agttgcttcc ctcagaacac
    16321 aagcaacttc gtaaatttgt tcagaatttg aagcctcgac tacaaagtta actgggaatg
    16381 ttgcttcttc gcctggttta acatcaaagt gatattcact ttcactaact tttctaccat
    16441 cttcgtaaac tctagctagg aaagtataag cagaaagatc ttcgaagaga ttatcattct
    16501 tgatagttac tgatttttca tcaacagcaa tcttaatatt agagtaaaga tgtttaactg
    16561 tttgaagttt tggagttagg gtacgatctg caaagacgat accatttcca caaaattcgt
    16621 agtcagaagg tctatcatgc cagtcaccac catatgatag gaattcgcta ccatttggaa
    16681 gtgttttgta aatagcttgg tcaatgaagt cccaaataaa tccaccttgg tattctggat
    16741 atttctctaa gtcagtgtag agttgcaatc caccaccaga gttacccatt gtgtgcatgt
    16801 attcacatga aatataaggt ttttgaggtt tgttagttag gttacctgaa gcaaagtgtt
    16861 tatcactaac gcttgaaaga tcaactagtt taccagttgt gaggtattct tcgatatcag
    16921 ctggtttcgc atacatacga ctttcgatgt ctgtaatgta atcaaactca cgacaccatg
    16981 caacaccttc atagtgaact ggacgagtat tgtcaacact acggaagtaa tcagccatgt
    17041 cagcaatatc tttaccagca tatgattcat taccacaaga cc
//
