LOCUS       c00024_JAHBRL0..       14182 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHBRL010000030.1 Streptococcus thermophilus strain Rico65
            Contig_30, whole genome shotgun sequence.
ACCESSION   JAHBRL010000030
VERSION     JAHBRL010000030
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:24:52
            Original ID  :: JAHBRL010000030.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14182
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14182
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[231:9182]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      232..9182
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14182
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14182
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(232..486)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2e-14, bitscore:
                     46.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENLNTLDLETLASVEGGGCSWGGAGGATVQGAIGGAIGG
                     AFGGNVVLPVVGSVPGYLAGGVLGGAGGTVAYGATCWWS"
     CDS             complement(737..1138)
                     /locus_tag="ctg24_2"
                     /transl_table=11
                     /translation="MKLKNISSSVLRSFRTITAALAVFLISISLSLYKSKISPGTWLTV
                     GALAFVVIFVNGLLYRMLKKRPDSVNLLTIRQSFIVFPVITFLVLSVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLSYLQVKKYFKQ"
     CDS             complement(1468..1635)
                     /locus_tag="ctg24_3"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIVMGLANLFRSLDAVHHTINLLGLTVLLYSL
                     LFKKWVQFQK"
     CDS             complement(2143..2373)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_4"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 9.5e-19,
                     bitscore: 60.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGVCSWGGFAKQGVATGVGNGLRL
                     GIKTRTWQGAVAGAAGGAIVGGVGYGATCWW"
     CDS             complement(2729..2929)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_5"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1e-08, bitscore:
                     28.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNKQLERFKKLDTNALSNVSGQGYGAQCVIGTTGMTIVGAAFFG
                     IAGAGAGFAGGSTAFCYDTAK"
     CDS             complement(2948..3124)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_6"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.5e-11,
                     bitscore: 37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGLSCDEGMLAVGGLGAVGGPWGA
                     VGGVLVGAALYCF"
     CDS             3381..4112
                     /locus_tag="ctg24_7"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEEAVAHELKSFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIIRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGETIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNKTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGR"
     CDS             4112..5452
                     /locus_tag="ctg24_8"
                     /transl_table=11
                     /translation="MLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLAF
                     NFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLITF
                     FIFPFFNISITDYKSSLLISIPSSIAPLCLSFLFIKLFKESFTILQKQKSNSPIQHIII
                     VANFFMFGYTLLLQSLMYLENTTHSSTLELRKLCIVISLVLFFIMIVFLERNIREMIQG
                     QLDFQKNLQLENLYTYNKHIECLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEVYDS
                     VLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGME
                     TLDFIIVTSIFLDNAIEGAIQTQNPKITISFWEDHCSQLLSISNTISEEKTETKTIFER
                     GVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     CDS             complement(5470..5631)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_9"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.6e-08,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQA"
     CDS             complement(5646..7013)
                     /locus_tag="ctg24_10"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEGLQK
                     QLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKTNTE
                     VNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQ
                     YATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQF
                     LQNAGQQLSSVETQINDTESKINQADVLLTNTLIQSPEDGILHLSQADKKATMAATGTE
                     LAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSA
                     TETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ"
     CDS             complement(7029..9182)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 306.8; E-value: 5e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_11"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1103.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.8e-45, bitscore:
                     145.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMM
                     TFARDYLLTILSQRFTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALAS
                     TILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSN
                     AMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQ
                     LILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRL
                     NEVYLIESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVG
                     VSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLE
                     NLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARAL
                     LTKSPVLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGR
                     VVETGSHQDLMSYPGFYYQLFRK"
     CDS             complement(10196..11941)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     287.3; E-value: 1.4e-87)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 314; E-value: 3.3e-95)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_12"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGTLSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVAIIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNI
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLI
                     DGVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKIRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     TMEGE"
     CDS             complement(11934..13565)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 366.8; E-value:
                     3.3e-111)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_13"
                     /transl_table=11
                     /translation="MGRVIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILA
                     TSYRLGQIMRSRLFEHFTKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDAS
                     ITALVTLITMFFSISWQMTLVAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQ
                     ESVSGIKVTKSFGYQEAELQSFQETNKMTFEKNMHTMKYDSLFDPLVLLFVGSSYVLTL
                     LVGAFMIQAGQITVGNLVTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIETLLEQES
                     DVQDPAYPLPSIENGRLDFAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGPTGSGKTALV
                     KLLLREHDVNQGAIYLNGHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNVRFGNPDFS
                     IDKVEEATKLAQVYDDIKDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILD
                     DSLSAVDAKTEDAIIDNLKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHDD
                     LLAQGGWYAKTYESQQLEMEGGEAHA"
     CDS             complement(13880..14086)
                     /locus_tag="ctg24_14"
                     /transl_table=11
                     /translation="MRERGQVWSYSEVKRESQLANYNTDGRYLSETTNFELYNFVREYK
                     TSDEIRRIWNPKKDESVIHDKDN"
ORIGIN
        1 acatctattt ttacaatcat caacgttttc aagagcgcaa taacggcctt gcccctcttg
       61 aaatgaggaa caaggccgtc gcctaatatt ttattatttc attgtccact tgacagggag
      121 ctattcaata tatgttcaag attatttttt atgtttattt ttattgacct ttttgaaaaa
      181 gatattacct aacaaagcaa caacaaaacc tataataaaa tataccatag attagctcca
      241 ccagcaggtt gctccatagg caacagtacc acctgcacca cctagaacac caccagctag
      301 ataaccagga actgagccta caactggtaa aactacatta cctccaaacg ctcctccgat
      361 agctcctccg atagctcctt gaacagtcgc tccacctgcg cctccccagc tacatccacc
      421 accttcaaca ctagcaagtg tttcgaggtc aagggtgtta aggttttcaa ttgtttgagt
      481 tgccatggca actaccccct aaaattttta tcgtgtgatc tctcaatcac atctttagta
      541 tagcattcaa gtgtctctat cagagctagc gtcccaaaaa gtggctatat gtcccgaatg
      601 gtaattccta aagaacatcc ttcaatcatt ggaaatcttc ctctaatttt cacatattta
      661 cttaatcact ttcttattat aacactttta tgcaaatatc ttatagattg cttacagaat
      721 aatcaagcaa atgcgtttat tgtttaaaat attttttgac ttgaaggtaa gatagaaaat
      781 cacagaggat taacaaaagc attaatacgg ctagtactat acggtctgtg gtatcactga
      841 atgttagtaa tgtgtaaaac tctacactaa gcactagaaa tgtgatgaca ggaaagacaa
      901 tgaaggactg ccgtattgtt aacagattta ctgaatctgg acgcttctta agcatacggt
      961 agagcagtcc attaacaaaa atgactacga aagctagtgc tccgactgtt agccaagttc
     1021 ctggcgagat cttgcttttg tagagagaaa ggctgatact tataaggaaa actgccaacg
     1081 cagcagtgat ggttctaaaa gatcgcaata cactcgaact aatattcttt aacttcatga
     1141 taaaacacct aaactatgaa taacctcagt cagtcttgca aacctaataa gctattacat
     1201 ttaactctat tcctctctgt attttattat acagctgtaa gatttcaagt aagcccttag
     1261 cgattaaatt ctactggaga tgtaatacag tagtgtcatt agtactgata ctttaaatag
     1321 gcgaatatac atatctttgt tttctctatt acaaagatat gcaatcaaat ataatataat
     1381 ctccgctatc attagcaaga ataattttac ttcgggaaca tcaaaaataa gcatttgcaa
     1441 gcatcttacg ttcaaagtga ccaaaggtta cttttgaaac tgtacccact ttttaaaaag
     1501 taagctataa agaagcaccg ttagccctag caagttaatg gtatggtgaa ctgcatccaa
     1561 gcttctaaat agattagcga ggcccattac gatgagaatg gtagccagta aatacggttt
     1621 tgagttttta aacatacttt tctccttaaa gtgtttttag ctagtctgtg cataatctat
     1681 gaattttatt atagattgga agccgataaa aaagtagtga cataaatgtc actacttgtc
     1741 tgaccttata tccttgataa ccgtacacat aagaaagaga aataaacata acccgataag
     1801 atttaggcat tgaagtccaa aattcagttt ttctccaaag ttatgtaagg caacaaggac
     1861 gaagcccata gacatcatta gagacactag gcgttttttg gtcatgatta caaataactc
     1921 ttctcttata tcgaaatttt caatcataat tcacatgcta ttcacagacc agcaattgac
     1981 aagacatttc agttaggatt tcttcttaac ggaagatttc ttcttaacgg aattggtagc
     2041 cttgtgtttt tcaagaaatg acataattgg cttatctaaa aaactcataa cagccatgga
     2101 aaccatccct aaaatataac ttttcaaatc aaacataatc catcaccacc agcatgttgc
     2161 tccataacca acaccaccta cgatagcacc tccagctgct cctgcgacag caccttgcca
     2221 agtacgtgtt ttgataccta gtcgtaaacc attaccaact cctgtagcta ctccttgttt
     2281 agcaaaacct ccccagctac atacaccacc ttcaacacta gcaagtgttt cgaggtcaag
     2341 ggtgttaaag ttttcaattg tttgagttgc catggcaact acctcctaaa atttttatcg
     2401 tgtgatctct caatcacatc tttagtatag catacaagtg tctctatcag agctagcgtc
     2461 ccaaaaagtg gctatatgtc ccgagtagta aaaaaaagac tgaatatcat ttttgattca
     2521 gtccatgtct tattgaaaaa gctttaacta attctttcta tactgcctat agactccaaa
     2581 taaaaagaaa aagaatccta ttgatgctaa caaaagttga tagatatttc ctgatgacaa
     2641 tagtactttg ctatataaat atatcatcgc aatagtcgaa aaaatgatta ggtatttctt
     2701 catttgtatc acctatctca aatgaagatt atttagctgt atcataacaa aatgctgtgc
     2761 taccgcctgc aaatccagct cctgcacctg cgatgccaaa gaaagctgca ccgacaatcg
     2821 tcattccggt agtaccaata acacattgag caccatagcc ttgaccactt acattagaca
     2881 atgcatttgt atccagtttt ttaaatcttt caagttgttt attattcata aattcctccc
     2941 atacaaatta gaaacagtat aaggctgcac ctactaacac cccaccgaca gctccccacg
     3001 ggccacctac tgcaccaagt cctcctactg ccagcatccc ctcatcacag gacaacccac
     3061 cctcaacact agcaagtgtt tcgaggtcga gggtgttaaa gttttcaatt gtttgagttg
     3121 ccatggcaac tacctcctaa aatttttatc gtgtgatctc tcaatcacat ctttagtata
     3181 gcattcaagt gtctctatca gagctagcgt cccaaaaagt ggctatatgt cccgaatggt
     3241 aattcctaat gtatattatt tctaaaattc agaaaaaaaa aaaaaatctc attttatact
     3301 cataaaaaat tgaaaaaccg ttttctttat gttacaattt ttcaataaac agtattcgtc
     3361 ataaaagaga ggactagacc ttgaagattt acctattaga agataattct attcagatgg
     3421 gtcgcttgga agaggctgtg gcacatgaac ttaaatcctt cggaaaagat ctatcttgtg
     3481 tccagtcttt tgacaaacct gaccagttgt tatcagctat cacttctaat acaagcgatc
     3541 agattttctt tcttgatatt gaaattaaag gtgaagataa gaagggactt gatatcgcta
     3601 aaatcatacg tcaaaataac ccttatgcta tcattgcctt tgtcactaca catatagagt
     3661 tcatgcctca agcttttggc gttacagcct ataaatacat caataaaacc ttagatgaag
     3721 ctagctttag aaaagaaata ggggaaacca ttgctcaagt cttccctatt aacgcaacta
     3781 ccacggatga gttttttctc tacaaaacag agtctcaatt aataaacctt cctatggatc
     3841 aaattctata cctatccaca tcagatatca aacaccatgt tcacctccag actatccata
     3901 ccctcatgga tatccgagca aatctggcag actttaaaaa gatacacaaa aagctctacc
     3961 catgccatcg gtcctatatc gtcaatacag atatgatcat ctctgtcaac aagaccaatt
     4021 atgaagctac cttaattaat ggtcaagttc taccagtatc ccgtatgaag ataggaaaga
     4081 ttgcacagat tgttgaggaa agaggcagat gatgttaaca acgttatggc tactttttct
     4141 caccctttta agtgcaggcc tagaaattat tcttttcctt tatttaatgg gacagaagat
     4201 tcgtctgagg tattttttcc tactccttat ttttaattta gcctttaatt ttatttataa
     4261 ccactcttct tggtttatca ttaaattctg gggtgaggat atctactatc ttctgctctc
     4321 cttcctttta tccactaaga ctaaaaaacc attaaaaata aagattttca atggtctctt
     4381 ccctgatatc ctcaacaacc ttagtttaag actgattact ttttttatct ttcctttttt
     4441 taatattagt atcaccgatt ataaaagctc tctattaata tccatccctt catctatcgc
     4501 acctctttgt ctatcatttc tctttattaa attattcaag gagagtttta ccatacttca
     4561 aaagcagaaa tcaaattctc cgattcaaca tattattata gttgctaact tttttatgtt
     4621 tgggtacacc ctactgttac agtccctcat gtatcttgaa aacactactc actcttcaac
     4681 tttggagctt cgaaaactct gtattgttat ttcacttgtc ctcttcttca ttatgattgt
     4741 ctttttagaa agaaacattc gtgaaatgat tcaaggacaa ttggacttcc agaaaaatct
     4801 ccagctagag aatctctaca cctacaataa acatattgaa tgtctctaca attctgttcg
     4861 tagttttaga cacgattata gtaatctctt agtcacatta cgattgggga tagataaaga
     4921 cgatatggat attgtcaaag aagtctatga tagtgtgctt caagaatccg ataaacgatt
     4981 aaatacaaga aactttgact tagctagact cgttaatatt caggataata ctttgaaaag
     5041 ccttctgtcc gcaaaagttt tacaagcaga agaagaaggt attgaagctc agattagcat
     5101 cccagaaccc atccacttga ttgggatgga gactctggac ttcattatcg tcacttctat
     5161 ttttttagat aacgctattg aaggtgccat tcaaactcaa aaccctaaaa ttactattag
     5221 cttttgggaa gatcattgtt cacagctatt atctattagc aataccataa gtgaagaaaa
     5281 aacagaaacc aaaaccatat ttgaaagagg tgtctccaac aagggacgag agcgaggcat
     5341 tggccttgct aatgtcacag aaatcttaga taactatatc aatgtaaact tagaaacaca
     5401 gagtaacaat ttctcattca cacaacaatt aacaataact aaaaaggcct aacagccttt
     5461 tttctatacc taagcttgag gaatgttata gtcttttgtt ggaagcgttc tttgccctcc
     5521 gaatcctttt aggaaaccat ttatataatc catccaccca cttccaccta cgacttgttc
     5581 aagagcgtgg ttatcaagtg tttcaaagtt attaatcgta ttgttagcca tcagtaattc
     5641 tcctcctatt ggtcttgcaa gtttagtaac ttgtctttaa agtaattgaa gtaggtcttt
     5701 tggtcaataa cgcttgtcac acgaccttct agaccgtaac gtagattttg ggcttctttt
     5761 tctgaaatac ttgccctagc agttactcta aacacattcc ccctttctgt ttccgtggca
     5821 gaattatcaa tactctcaag ttttccaata attgtggtac cgtgattacc aaccttatcc
     5881 aaggtcagtc gaactgactg gcctttttgc agttttggca cataatccga attcacataa
     5941 taagtaatgg caacttcctg ggtttgagtc atatcgggat aaagctgggc caactcagtt
     6001 cctgtcgcag ccatggttgc ttttttatca gcttgactca agtgtaagat tccatcttct
     6061 ggtgactgga tgagggtatt agtcagaagg acatctgcct gattgatttt actctcggta
     6121 tcgttaattt gtgtttccac tgagctcaat tgctgtcctg cattttgcaa gaattgattt
     6181 tttagagctt cttttttagt gctatcacta ttgtcataag ttacaactgt gcctgtccca
     6241 gccttttgga tttctagatt acctatggaa gcattcaagc tcgaaatatt ggtattaact
     6301 tgagataggt attggtctgt tacactggca tccggtgtcg tagcatactg actgttatag
     6361 gcatttaagg ttgcctgatg aggattgcct tcaggtaaag tcgtttcatg attggtaata
     6421 gcttgagaga gcgcctcata ctctgagacc tgagtctgca attgactaat ctggttatca
     6481 atagcagaac cggtattact cgcaattgct gcttggttat taacctctgt atttgtttta
     6541 gccacaccca agtcaatatc ctgtgcctga cttaggtagg tgttaaaagt actctgataa
     6601 ccaaactcgt cttcctgttc ttggaaaaga ttggttccct gcgttaggct agattgcaag
     6661 gtcttcaaac ctgattcctg tctttttaaa agttctagtt gcttttgaag cccctctttt
     6721 tgcgatgcct ccatggtctc tgaatactga actaaggtgt cccctttttt aacaacctta
     6781 ttagcaacca gttgattatc tatgatggta ttgtcactgg ttgattggat tactgcgata
     6841 accttggttg gctctatact tcctctagac gtgactgtaa cttccttctt agcaaaaaaa
     6901 gcgaaaagaa aaaggaaaat aactaacaaa atcaagggag taatcaaaac agtagacata
     6961 ttgtggtagc gacgatggta aaactctgtg cttttaaaca actgtggatt catcgtgttt
     7021 ccttttcctc actttctaaa taattgataa tagaaacctg gataagacat taggtcttga
     7081 tgagaacctg tctccactac gcgtccgtga tcaatgacta cgatacggtc ggtccgctca
     7141 gcgatactaa gcctgtgtgc tacaaagatg atcgttttat cttttagtgc taggaggtta
     7201 tcaataacct gcttttctgt caaaacatcc aatccgctag ttgcttcatc taagattagt
     7261 acaggagatt tcgttagtag tgcacgcgcc aaagcgatac gttgcttttg ccctccagac
     7321 agacctgctc catcagacag ctctgtctga aaccccatag gcatgttttc aatatcttga
     7381 cgaatttctg ctatttcaca agctttcaaa atatcagctt gcgtaatacc ccgtgctgca
     7441 cctaaagtaa gattttctaa aacactacca ctaaatatat aggattgctg agggagatag
     7501 ttaatatgtt gacgaagagt tttcttgtct atgcgactaa tattttgacc attaaaatct
     7561 atgtgcccct tatatggttg ataaaaattg accaacattt tagctagagt agtcttacca
     7621 gatccactga caccaacaaa actgattttt tctccttgtc taatcgtcaa actgacatca
     7681 gtcaaagtat cacgaccaaa accatattta taagataaat ccgtaacagt gatatctcca
     7741 tccgcaatgc cttcttgata ggtatcatca ctttgtccaa actctgattc aatcagatag
     7801 acctcattga gcctagtatt agctacctta gcagactgta acttggtttg caggttaatg
     7861 atattttcca aaggattcgt gaagtaagaa agcaacatat taaaagtaat caattgtcct
     7921 atcgaaatgg tatttcccat caccaactga gcacctgtcc agaggataag tacatttaaa
     7981 ataagttgag caccttgttt caatgatgtt tgtagtatag ataacttaga aaggcgaaaa
     8041 gaattgtcta gatagtcaat aaactcacca tcaatctttt gatagcatac ttcttcgctg
     8101 gttagtgact ttatggtttc aatcccatta atgtcctcaa tgatggctga attaaccata
     8161 gcattactct gcatgacgtc atgattcatt cgctcaaaag gtttcataaa ggcaaagacg
     8221 ataagggtat aaattggaac cgaacaaaga actagcttga agagattgct attttgtatc
     8281 aataacacgc ctcctacgat aatcacaata gagaaatcaa ggaaaagtga taatatcgtc
     8341 gaagccagag catcgataat agagttagca tcactaaaac gtgagataac ctcccctgta
     8401 cgtcttgtgg caaaaaaaga cattgggagt tcaaagatat gtcgtatgta ggacaagata
     8461 acgtcaatgg taaatcgctg actcagtatg gttaagagat aatctcttgc aaaagtcatc
     8521 atttgttgta aaacataggt cacaactaat ccaattgaga taattcctaa ggtagacttc
     8581 atttgattag ggacatattc gtctagaata ccttgtaaat aataggaacc taaaatattt
     8641 attaaagtaa ccaagagact ggcaaagaca atattagcta tcaaggacct ttgtttaaag
     8701 atcaaaggga gaaagtccca gagtccattt ttcttatcct tatgtggttt ataactgggt
     8761 tccggtccca taaaaagagt aacacctgtc cactctttct caaaacgctc tttagtcatt
     8821 ttagttactt ttacacttgg atcagggtct ccaattatca gataatcctt ggtgctttta
     8881 taaataacat aataatgttg aagcttccca tctttattaa catgagcaat aaaaggataa
     8941 ggaacatctt ccatctcaaa gagcgacatt tcagccttta tagctctcgt ttcaaagcca
     9001 atttttttag cagcctctac aagacctaag gcagttgtcc cttctttatt ggtcttcgcc
     9061 aactcacgca gatgtgctaa tgaataatct gaaccatagt acttggccac tgatgccaag
     9121 gcagcaactc cacaatccct catgtctatt tgagggacaa aagtcctacg aaaacgaaac
     9181 ataccaaacc ctttcatcac aaattatcat atgattagta tgtcatattt tcaggataaa
     9241 aagagccagc gtcccaaaaa gttgccatac gtcccaaacg gtaagaaaaa tcttaaagtc
     9301 atctccacta ttaccattta agccgtattt ggggtcattt aggacaagtt cattgaaatc
     9361 gatttcaaag ttatacaata gttattagaa ggaaacattc taaaatagtc ctacaagcat
     9421 acgtatttga tctaaccatt attactgtgc cagccctggt atttccaaag gaaaccatga
     9481 ctgctgatag cctcggagcc tatctctatc gtatgatgtc ataatttgat tatttttatt
     9541 ccgaaaaggg ataacattat gaaaaacgtc aatccatatc tcaaaaaatc ctatcaaaaa
     9601 aggctaaatc agcctcttga gattcgatta ctcaattatc ggtttaattt tccttagctt
     9661 tgtaagtgta tttgttatca ctgtcaatgc tatttttagc gtcactagag gggttccctt
     9721 ccttaatgcc caccttattt ccaccttgag taattgtgcc ttctatcttt tgatttactc
     9781 aaccttgagg tggcaccatc tcaaaaagct ctataatctc tacagtggtt tttcccacta
     9841 cagaaattat agagccgaag ttaagtagtt ctgtggtaaa ctgagtcata ggaataaatc
     9901 tctttctagt aatgttttgc aactctacta taacggattt attccttttt gtgtttacac
     9961 aacttatttt acactacctc aacgtttgca agtacctcga gatcgagtgt ttcaaatgta
    10021 ttatttgttt gccttgtcat tctaacaacc tcctaaatta tttttagctt tttctctcaa
    10081 gctatgattt tattataggg tggtagccaa caaaaaagta gtgacataaa tgtcactact
    10141 cgattttgat ttttaagaaa tcttttcgaa tatagaagct atggtctaga ttagcttact
    10201 ctccttccat ggtgcctgct tgtaggctgt acatcttgtg ataggtgccg ccgagggcta
    10261 ggagctcttc gtggctaccg tgttcaatga tgcggccctt gtctaagaca tagatgcagt
    10321 tagcatcttg gattgttgat aggcggtggg caatggcaat ggttgtacgg ccttgacgaa
    10381 tttttgcaag agagttttga acaatagcct ctgtctccga atcaatattg gctgtcgctt
    10441 catccaaaat caagatttta ggctggctag caacggttct agcaaaggct agaagctggc
    10501 gttgaccggt tgagaaactt gaaccacgtt cggaaactgg ggaatcatag ccttcaggaa
    10561 gtttatcaat aaagtgattg gcatcgacaa actcagcagc agctttaatc tcttcatcag
    10621 ttaaatcttg atacatggca atattggatt tgattgtgcc atgatagagg aaggggtcct
    10681 gaaggacaag accaatattc ttgcgcagct ctgcctgact ataatcacga atatccacac
    10741 cgtctatgag aactcgtcct gattggaatt catagaatcg catgagcacg ttgataatag
    10801 aggattttcc agagcctgta gatcccacaa aggcgatggt ttcaccttta ttgacagaga
    10861 aggaaatatt atccaaaatc tggtgcttgc catcatagga gaaggagaca ttctcaaagc
    10921 gaatattccc ctcagtaacc ttggcagctg tgtctctctg ttcaggctca taggtacgct
    10981 cgtcaatcaa ggcaaagacc cgacctgctg agaccataga ggtttgtaga gtcgagaagt
    11041 tttgtgtcac ttcaatcaag ggatcaaaga ggcgattaat atactggata aaggcataca
    11101 tggtacctgc tgtgataccc agatagatac ctcggtagcc aaaataggcc atgagaacag
    11161 cataagccag gagcttcagt agactcatgg ctgggcgtag aaagagagaa tccagtgata
    11221 tagaacggct ggcataaatc aggtgttcct cattaatggc atcaaactct tttttaagac
    11281 gcttctcctg gttaaaggcc tgaatgatgt gaatcccttc gatactctct gacagtttgg
    11341 catttatatc tgaaagcaag gctctggtct tttcaatgat ggccactgat tttttgcgat
    11401 aaaggttaac caaaaggaca atcagaggaa gaaagaggac aataagcccg gtcagacgaa
    11461 tgtccaagat catcatggtg taaagggtgg taacaaagat aaagatagcc gaaataaaac
    11521 tagacagagt tcctgagaac atctcgctaa tggtctcagt atcattggtc aagcgggaaa
    11581 cgatggaacc tgctggggtc ttgtcaaagt aagacatacc cagtttttcc atattggcaa
    11641 aggcatctcg acgaatatct ctgacaatgc tataggacac acgcgcaaag aagagatttc
    11701 ccagatactg gactagtgtc tgcaagaggt agagaccata gtagccaatc agaatcatac
    11761 ttgccgcctg attcatatca tgaagatagt gatcaataaa ataagaggcc accaagggaa
    11821 tgatactctt gataaccgtt gtggacaaga ggaaggtcaa agctagaaag gtcaagaact
    11881 tgtaaggctt gagataggtc aagagacgct taaacacaga ccattggttt tgattaggca
    11941 tgagcttctc ctccttccat ttctaactgt tgagactcat aggtcttggc ataccaacca
    12001 ccttgagcta gtaagtcgtc atgacgccca cgttcaatga tacgaccatc ttgcatgacc
    12061 aggatgaggt cagcgtgcac caccgcactg agacggtggg cggtaataat agttgttttg
    12121 tccttgcgag tatgcttaag attatcaata atggcatctt ctgtcttagc atcaaccgca
    12181 gataaggagt catccaaaat caaaatttct ggattcaaaa tcatggcccg gctcatagcc
    12241 agacgttgtt tttgaccacc tgataggctg acaccctttt caccaatgat tgtttcaaag
    12301 ccttcaggca tatccttgat atcatcataa acttgagcta acttagtcgc ttcttccacc
    12361 ttatcaatgg agaaatctgg attaccaaag cggacattgt ctaaaataga actggcaaag
    12421 agaaactggt cttgaggaac ataaccaatc aagctacgca agtctgatag gcgatagtct
    12481 cggatgtcat gtccattcaa atagatggct ccttgattga catcgtgctc ccgcaagagc
    12541 aacttgacaa gagccgtctt tcctgagcca gtcggtccaa ccaaaccaag ggtttgcccc
    12601 ttgtccaagg tgaaatgaat atctcgcaaa gtatcctcat cctcaaaagc aaagcggtca
    12661 atcgcaaagt ctaaacgacc attttcaatg cttggaagag gataagcggg atcttgaaca
    12721 tctgattcct gctctaaaag agtctcgata cgttggtagg acacatttcc cctctgcgtg
    12781 atattaaaga ggaagccaat ggccattagg ggccaaacca gcatgtccaa ataggtaata
    12841 aaggttacca aatttccgac cgttatctga ccggcctgaa tcataaaggc cccgacaagg
    12901 agggtcaaaa cataagatga gccaacaaag agcaaaacca agggatcaaa aaggctgtca
    12961 tacttcatgg tatgcatatt cttttcaaaa gtcatcttat tggtctcttg gaaggactgg
    13021 agctcagcct cctgatagcc aaaagacttg gttaccttga tacctgacac cgattcttgt
    13081 accttattat taagttcaga aaaagctgcc tgggattctc caaaagcttt gtgggtctta
    13141 cgtcccaaac gactagtcgc aaaagccatg aaaggtagag gtaagactgc caccagggtc
    13201 atctgccagg aaatgctgaa gaacatggtg attaaagtca ccaaggctgt gatagacgca
    13261 tccacggctg acatgacacc cccaccagcc aaacgggtta gagagttgat atcattggtg
    13321 gcatgggcca tgagatcacc agttcggtac ttttggtaaa aagaaggcga catcttggta
    13381 aaatgctcaa aaagccgcga acgcataatc tgtcccaagc gataagacgt tgccaagata
    13441 tacatccgcc aaacatagcg caaatagtac attcctaaag ccgccaaaag caaataaacg
    13501 agattcaaaa gcaagatctg attggtcaat tttcccgatg tgatagcatc aatgacccga
    13561 cccataacca taggaggaat cagattgaga accgaaacca aactcagtgc caatatcccg
    13621 acaatataac ggcgtttttc taacttgaaa aaccaccaaa gttttgcaat gattgattct
    13681 ttaaaaaaac aagttattcc ccctatccct acaaaaggat gattataagt ctaatgaaag
    13741 ttatttccaa tagcgataaa ttgtaccatc ttctaactga aagtgaccaa tataagtcaa
    13801 ttttccaaaa tcagtagact ctggcaattg ataagcaaag gagtcaaaat tatagacctt
    13861 gtgcccatca tcaatagaat cagttatcct tatcgtggat aactgattcg tccttcttag
    13921 ggttccaaat acgtctgatt tcatcagatg tcttatactc tctgacaaaa ttgtacaatt
    13981 cgaagttagt tgtctcactg agatagcgac catcagtgtt gtagttagct aattgagact
    14041 ctctcttaac ctcagaatag ctccaaacct gccctctttc tcgcataata tcggcatcac
    14101 ggccactttt gataagtatc tgctttaacc attgtcattg ttgctcctag tgtcaatacg
    14161 gtgactactg tcacattaag tg
//
