LOCUS       c00023_JAHDUT0..       15395 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHDUT010000003.1 Streptococcus thermophilus strain Nect13 Contig_3,
            whole genome shotgun sequence.
ACCESSION   JAHDUT010000003
VERSION     JAHDUT010000003
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:39:36
            Original ID  :: JAHDUT010000003.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15395
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15395
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1341:5395]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1342..5395
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..15395
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15395
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03882))"
                     /tool="antismash"
     CDS             complement(50..166)
                     /locus_tag="ctg23_1"
                     /transl_table=11
                     /translation="VNFGVNFINFNKKGSIISVVGKTTVEIIELFECTLKVP"
     CDS             complement(229..402)
                     /locus_tag="ctg23_2"
                     /transl_table=11
                     /translation="MNSVRRRHPELSPASPHKLRHTGATLARKSGVPLEIISEALTHSD
                     KQITKTYVNTKI"
     CDS             546..809
                     /locus_tag="ctg23_3"
                     /transl_table=11
                     /translation="LAHDFASWVSGDSMEPKYHNGSVALIRETGFDYDGAVYAVVCNSQ
                     TYIKRVYLEAEGLRLKYKDIFISYDEDPRVVRIIIGNFIPLK"
     CDS             1059..1163
                     /locus_tag="ctg23_4"
                     /transl_table=11
                     /translation="MENTEFSLELDVTEVSTEQGYVSGGVTSTGCCKD"
     CDS             1342..1620
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_5"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.4e-15, bitscore:
                     45.2, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLVANPQFFHNLTKEKIYKNSTFRNYVKRSITRATPFGLFSSIG
                     VGTFSDISYHQKIGENYTKKISVSGEWLSSICMMLENKDSVLLQLHI"
     CDS             1771..4134
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     577.3; E-value: 8.8e-175)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_6"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.9e-65, bitscore:
                     210.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.2e-19, bitscore:
                     59.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VLELVLQSKSPDLEKQKILDYIRNLITNEFLFTNLRKVAISHKDL
                     DDLTNILKDINNQRKLTEDLLQIKNSIEQYAKLELGEGISQYTEICKKMSYIFNDKKQH
                     YLKVDLVNCCDSVLPKNLKKKMEDFVNFISKINLAKGYRNRELESFTEKFVEKYGEYVE
                     VPIKELLDGNLGLGLPKQTLGTHVKSSSSVEEQNFLSYLSKEVFKAVKNCKKEIDISNI
                     PLGLLYPNSDRFVANQLELYCEIKNFESQPVISVVPNTGSDMIGKSIGRFASYFPNSYI
                     SLDSQLDNVELIEFPRDSKNLNVMSAQNAHSKKLLLSYDDNDNTSIELDSVVVGVIKTE
                     YRYKLYFRDLRTGSIVNFVTTSMLNHKSNGVFSDLARFLLAVSLEWQDNPFSVFRIIEN
                     FDYLPYIPKIKYGNIILSEEKWVLSDIDKNDLSSIKQWKKDFDVPRLLYFHKADERLLV
                     DLENDLDTQWLLKQNVDKLYFTRFEKYDGKNCEFIFGFENYQSSINHYSMQEKSVRRLT
                     NNFYKNHVKTFSSDWIYFRLYGINSSILLELRERLLLFTDELLVEKLISDFHFVNYSDK
                     DNGSLRLRFKINNDDNFEDLRFRIAHWIDFLLESGFCNDVSFNLYEREIERYGGDNFIT
                     VCERMFSIDSFLTLKLFSKKLLNDKDLFSVLHSTFLYIRLLGIPLKRLLELLKGNLTQN
                     RYRKSFKKLFPNNTIVVKEFKEYFDYKNQFEIFNEVFREFPPIDGYFEGKNDIVYSLLH
                     MHMNRVGMFPYREKEYLYFIMYIAEPLNNYKEFT"
     CDS             4172..5395
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     308; E-value: 1.6e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_7"
                     /sec_met_domain="LANC_like (E-value: 6.5e-52, bitscore:
                     167.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VLDSDIIDRLQRAYYTENRSYLSEYPSIIIYLSYRLINCDNKEYS
                     KLLYNRVNYYLQELLKSIKLNSTNNISLCYGFTGYVYALEFLSKNCKGYDKLLDTLETI
                     LLALTKDRLREIKSSNIVKEEYFDVIQGVSSVARYLLSKEESTSEQELLVKEILNYFAD
                     LIINEPTIYVEYMPNEKLRKRFPSGYINLGVAHGILGPLYVLALGFEKFNITKHIPSIE
                     KGLSYYENAFFTNTIGKIIGWNGRVSDYGENEEFRFNISWCYGSLGMARVLYNIAKIID
                     SQKLREMAMDVFTSSIDYLNSSEILNNGICHGRSGIMLLFNLMYLDTGKTQFKAISDNL
                     FKEIINDASNSEYIFVERDIYFRGVTFDEVIDYIDFGLLNGVSGIVITLMAQRTGNAYP
                     LDRMLFMQ"
     CDS             5419..6684
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 96.3; E-value: 3.3e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg23_8"
                     /transl_table=11
                     /translation="MRKILKNKLYLKVLVSDLISNFGDTLYFIALMTYVTEIKDSNLAI
                     SIVNISETLPILFTIFFGIIADKTLNKVKMIIKTLWLRVLLYLLVAVAMNFKPSIMIVI
                     IASLVNLVADTLGQFENGLFYPISNRIVKKSDREETMAFRQTVVSVMNIINQSLGAFLI
                     TFFSFSHLAFINALTFAISLLIMLAIKNQINSYYDETISTSKISQFDFKASFSEITSNL
                     KLSINHLFSIGNMKEALLVIPILNGSLAILTPLVVVDLSKDSNLTIINSAITISLLGIS
                     TVSGGILGGTLILISKKFKSLSIGTLLKMNLTTVLLSFVAFYFQNIYLIILSSFLSSVL
                     VSALNPKMGTIIFNNIDETKLATIFGGMVTYFQIGDIVSRLLFSTLVIYLPYGYIALIY
                     IAVVFVAILYTLKSSNHIEREF"
     CDS             6913..7425
                     /locus_tag="ctg23_9"
                     /transl_table=11
                     /translation="MMFDDRLEIHSPGKLPNIVTVENIKHERFSRNPRIARTLTEFGWV
                     REMNEGVKRIYSEMESYFLHEPKYTEPGNKVVLTLENNILSRHLRVNDKMMKKYDEFND
                     LNDDEKAILHIMYNTGEKMTTALAARITNRGRNFASKLLKSLVNKEILEWHGTSKQDRN
                     QYYTLAE"
     CDS             complement(7762..8076)
                     /locus_tag="ctg23_10"
                     /transl_table=11
                     /translation="LRQTQKQFVFTYNDRSNNINLPLHVDYLNYRMKSVRRRHPELAPA
                     SPHKLRHAGVTLAKQAGYSLEAISEALTHSDKQITKTYVNTKDIVNRTVGDIAFRSLKK
                     "
     CDS             complement(8368..8979)
                     /locus_tag="ctg23_11"
                     /transl_table=11
                     /translation="MSIKKTKNGTYQLRLYIPEDVQAKLGLGKLFERKYKTRREAKEVE
                     LKLSIDIKNAKSGKSHINIKNKGEIIFKKFYEDIWLEPYKAGQTTTTIKPPTKATVFQT
                     ENIFRLHILPILGKYSIEYPNNNKQLILSLLTPKANSYANFKVIRSYVNSVFDWAEELE
                     YIPSNKLRKTITRIKANKKILLKESKREEDLSLDKEELKL"
     CDS             complement(8990..9262)
                     /locus_tag="ctg23_12"
                     /transl_table=11
                     /translation="MLVQLPEEQTQEIQQMIATLIKNEIHHFKEDIGADSTFLNKKQTY
                     NYLGISNNTLDIGIAMGLPYIRIGKSIRFNKKSINQWMTRLEISA"
     CDS             complement(9324..10514)
                     /locus_tag="ctg23_13"
                     /transl_table=11
                     /translation="MIKESFPFDILNLFDTKGTPPFNFSNQYLNPNTKILDFNNATLYE
                     VDFDSLSPDTKAKLQEGAYKIGESRKVEGNLRAVIVDTTDQKNRVEDLTLRKMTNNNEN
                     QVPSDLIAQAQLKQIYNLLLDIKENQDYQIRWERNNSILAPFYSARTKVIEANNSKDFR
                     EKVKSLKDANTLFEESVSAIKSDIISNRDEIIKKISQPTYRQASLQTHADFLLQDIEIM
                     TKIVGMQIYIDLTLNNEGIAHDRLLSFQGSMELVSKQNIPYKTNYLKELAKKLLYVKEL
                     KWIKNNSIPKVSLLELIHNHYSYSKNNRDLFININTKLIEFHQDSNVNLSNTETAKIET
                     EKKMTLKTKKCKTCKKTISSPKTIPICDACRNKGKQLTVVGVALLVFFNKIINKKN"
     CDS             complement(10761..11018)
                     /locus_tag="ctg23_14"
                     /transl_table=11
                     /translation="MGNGGQWMNAPGYQTTHTPTEHSALSFSPGQAGADPTYGHIAFVE
                     QVKSDGSILISESNIKGLGVVSYRTFDAETAKQITYVIGH"
     CDS             complement(10994..11335)
                     /locus_tag="ctg23_15"
                     /transl_table=11
                     /translation="VVLSTRQQMVASTSPIPLALGKGVLKPCKNSIPISMSMEVHQKPL
                     NRRKEKPETEAVSQQGMSHKAIASPKKSIPQATQDCLILGDNVPGLSITEEKKSVLASE
                     SIWEMVANG"
     CDS             complement(11526..11714)
                     /locus_tag="ctg23_16"
                     /transl_table=11
                     /translation="LIEQDHRPVKRHNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTL
                     FGFSVCTEIKVLLGIPA"
     CDS             complement(11720..12214)
                     /locus_tag="ctg23_17"
                     /transl_table=11
                     /translation="MTINHFKGKQFQQDVIIVTVGYYLRYNLSYREVQEILYDRGINVS
                     HTTIYHWVQEYGKLLYQIWKKKNKKSFYSWKMDEIYIKIKGKWHYLYRAIDADGLTLDI
                     WLRKKRDTQTAYAFLERLVKQFDEPKVVVTDKAPSITSAFKKLREYGAFIKGQNIVPLN
                     T"
     CDS             12364..13581
                     /locus_tag="ctg23_18"
                     /transl_table=11
                     /translation="MKQSQAKKHDNTMTNKILMRLIALVLGLLFLEILIIHSKNEQQKS
                     VSNQVQTARIMANGDLLYHDGLYMSALQADGSYDFTENFTYVKPWLKQADLVLGDFEGT
                     INPDYPLSGYPLFNAPQSVTAAISDAGYDVMDLAHNHILDSGLEGAFTTADAFKEVGID
                     PVGVYENPVRDKAPLFIKNVNGIKVAILSYAYGFNGLESNLTEKEIANHLSNLDEKRMK
                     VEIERAEKEADVTVIMPQMGVEYRLEPTDEQVKLYHKMIDWGADIIFGGHPHVVEPSEV
                     VKKDGQQKLIIYSMGNFISNQRIETMDGVDSAAWTERGVLMDVTLEKKNCQTTIKTAQA
                     HPTWVNRTPKGTISPEGYPLYTYQTYILEDFIKGGKYRNKLDEETKERIDTAYKEMNAH
                     VNLKWK"
     CDS             13902..14168
                     /locus_tag="ctg23_19"
                     /transl_table=11
                     /translation="MKAIITVVGKDKAGIVAGVATKIAELGLNIDDITQTILDEFFTMM
                     AVVSSEDKKDFTHLRAELEAFGESLNVKINIQSSAIFDAMHNL"
ORIGIN
        1 tctcataagt tcttcctaat ggtagttttg tcacttttca ttatagttct tatgggactt
       61 ttagtgtaca ctcaaaaagc tctataatct ctacagtagt tttacccact acagaaatta
      121 tagagccttt tttgttgaaa tttataaagt tcaccccaaa attcacccca tgttcaccct
      181 attatttttt taagcttcta tatgcaatat ctccagcagt ttgatttact atatttttgt
      241 gttaacatag gtctttgtaa tttgtttatc actatgagtt aatgcctcgg aaataatttc
      301 taggggaacg ccagattttc ttgcaagagt ggcacctgtg tgtcttaact tatgtggtga
      361 agcaggggat agttctggat gcctacgtct gacagaattc attctatagt tgaggtaatc
      421 tgtatgaagt ggaaggttga tattattgga tcggtcatta taggtaaaca caaactgctt
      481 ttgagtctgg tgtaaaccaa atagttttaa ttccttatta tgaaacggtt tactttacgg
      541 aggagttggc gcatgacttt gcctcatggg tgtctggaga ttctatggag ccaaagtatc
      601 acaatggttc agttgctctc attcgtgaaa caggttttga ctatgatggt gccgtatatg
      661 ctgtggtatg taatagtcaa acatacatta agcgagtata tcttgaagca gagggtctac
      721 gtctaaagta taaggatatc tttatttctt atgacgagga tccacgagta gtgagaatta
      781 ttattggaaa ttttatacct ctcaaataat acgtttttct agtcctgaat tgtcaacttg
      841 tttgcttttt tgataatgat tctagttttc aaaaatgtaa tgacatctgt taaggatttc
      901 ttatgaaata tcttctgata acagagcttg tttgatagta cagacggatt ttattttata
      961 atactccgaa acaaaaagaa tgaattttct aaaaattatt gacaaataaa tttgctttta
     1021 gtattataaa cacaacttaa agaagaggca gagttatcat ggaaaatact gaattttcat
     1081 tggaacttga tgtaactgaa gtttcaacag aacaaggtta tgtttctggt ggtgtaacat
     1141 ctacaggttg ttgtaaagat tagttttata attgattgaa taaggcaggt atacgaggta
     1201 cttacctttt tttacaagag aattatgttt aagataaaag ataattacat ttataggtaa
     1261 tgcgttaatg attcaagact tatagaaaaa cttagtgaaa ataatcttga aatatttttt
     1321 gataacaaag tttttaaaga aatgttgcta gtggcgaacc ctcaattttt ccataattta
     1381 actaaagaaa aaatatataa aaattccacc tttagaaact atgtaaaaag atcaattaca
     1441 agagcaacgc cgtttggatt gtttagttca attggtgtag gaactttttc tgatatctca
     1501 tatcatcaaa agattggaga aaattatacg aaaaaaatct cggttagtgg agagtggcta
     1561 agttcgattt gtatgatgtt agaaaataaa gattctgtct tattacaact acatatatag
     1621 tggaaccaaa aagtacttga attatcagat aagtatcaat taagtaatgt caattactgg
     1681 ggaatctctg agataagtaa ggatttattt atcaagaaaa ctggactttt agaattcata
     1741 caaaaattaa cgtataaatc ggaagtcagt gtgttagaac tggtacttca aagtaaatct
     1801 cctgatttag agaagcagaa aattttagat tatatacgta atttgattac taatgaattt
     1861 ttgtttacaa acttgcgaaa agttgcaata agccataaag atttagatga tttaaccaac
     1921 attttaaagg atattaataa ccaaagaaaa ttaaccgagg atttattaca aataaaaaat
     1981 agtattgagc agtatgcaaa attagagttg ggagaaggca tttctcaata tactgaaatt
     2041 tgtaaaaaaa tgtcgtatat ttttaatgat aaaaaacagc attacctgaa ggtggattta
     2101 gtaaattgtt gtgattcggt gctgcccaaa aatttaaaaa agaaaatgga ggattttgtt
     2161 aattttattt caaaaattaa tctggctaaa ggttatcgaa acagagaatt agaatcattt
     2221 acagaaaaat ttgttgaaaa atatggagaa tacgtcgaag ttccaattaa agaattatta
     2281 gatggtaatt taggactggg tttaccaaaa caaactttgg gaactcatgt aaagtcatca
     2341 agtagtgtag aagagcaaaa ttttttgtct tatctgagta aagaagtctt caaagctgtt
     2401 aaaaattgta aaaaagagat agatatatca aatatacctt taggattgtt atacccaaat
     2461 tcggatagat ttgttgcaaa tcagttagag ttatattgtg aaattaagaa ttttgaatct
     2521 caacctgtta tatcagttgt cccaaataca gggagtgaca tgatagggaa gtctattgga
     2581 aggtttgcct cctattttcc taattcttat atctcgttag attcacagtt ggataatgta
     2641 gaattaatag aatttccaag agatagtaag aatttaaatg ttatgtcggc acagaatgct
     2701 cattctaaaa agttattatt atcttatgat gacaatgata acacatcgat tgaattagat
     2761 tctgtggtgg tgggggttat aaaaacagaa tatcgatata aattatattt tagggattta
     2821 cgaaccggct caattgttaa ttttgtaaca acatcaatgc taaatcataa atcaaatgga
     2881 gtatttagcg atttagcaag atttttgcta gcggtttctt tagaatggca agataatccg
     2941 ttttcagtgt ttaggataat tgaaaatttt gattatcttc cctatattcc caaaattaaa
     3001 tatggaaata taattttaag tgaagagaag tgggttttgt cagatataga taaaaatgat
     3061 ttatcttcta ttaaacagtg gaaaaaagat tttgatgtac ctagactact gtattttcat
     3121 aaagctgatg agcgtctatt ggtcgattta gagaatgatt tagatacaca gtggctttta
     3181 aaacaaaatg tggataaact gtattttaca cgttttgaaa aatatgatgg taaaaattgt
     3241 gagtttatct ttggatttga aaattatcaa agtagtataa atcattattc tatgcaggaa
     3301 aaatctgtta gaagattgac aaataacttt tataagaacc atgttaaaac attttcgagt
     3361 gattggatct attttagatt atatggaatt aattcatcaa ttctacttga actaagagag
     3421 cggcttcttt tgtttacaga cgagctattg gttgaaaagc taattagtga ttttcatttt
     3481 gtaaattata gcgataagga taatggatcg cttcgattac gatttaaaat aaataacgat
     3541 gataattttg aagatttaag atttcgaatt gcacattgga tagacttcct actagaaagt
     3601 ggtttttgta atgatgttag ttttaattta tatgagaggg aaattgagag atatggtgga
     3661 gataacttta taacagtttg tgagaggatg ttttctattg acagttttct taccctaaag
     3721 ttattttcga agaaattatt aaatgataaa gatttatttt ctgttttgca ttcgacattt
     3781 ttatatattc gattattagg gatcccatta aagcgattac ttgagttgct gaaggggaat
     3841 ttgactcaaa atagatatcg taaaagtttt aaaaagttat tcccaaataa cacaatagta
     3901 gtaaaggaat tcaaagaata ttttgattac aaaaatcagt ttgaaatttt taatgaagta
     3961 tttagagagt tcccgcctat tgatggatat tttgaaggta aaaatgatat agtctatagt
     4021 ttacttcata tgcatatgaa tagagtaggc atgtttccat atagagaaaa ggaatatctt
     4081 tattttatca tgtatattgc agagccgttg aataattata aggaatttac ttaaaaagta
     4141 tgaagaaatt atctgtaaag tagataaact cgtgttggat agtgatatta ttgacagatt
     4201 gcagagagca tattatacag aaaatagaag ttacttatca gaatatccaa gtataattat
     4261 atatttatcc tataggttga taaattgtga taataaggag tattctaagc ttctctataa
     4321 tagagtaaat tattatctac aagaattgct aaagtctatt aaattgaata gcactaataa
     4381 tatttcactt tgctatggat ttacgggcta tgtatatgcc ttggaatttt tatctaaaaa
     4441 ttgtaaagga tatgataaat tactagatac acttgagaca attttattag ctttaacaaa
     4501 agataggcta cgtgaaataa aaagctctaa tattgttaaa gaagaatact ttgatgtaat
     4561 tcaaggtgtc tctagtgtag ctagatattt gcttagcaaa gaggaatcaa cttctgaaca
     4621 agagttatta gtaaaagaaa tattaaatta ctttgcagac ctaataatta acgagccaac
     4681 tatttatgtg gaatatatgc caaatgaaaa attaaggaaa agatttccta gtggctatat
     4741 taatctaggt gtagctcacg gtatattggg accactatac gtgttggcgt taggatttga
     4801 aaaatttaat ataacaaaac acataccttc aatagaaaag ggcttgagtt actatgagaa
     4861 cgcctttttt accaatacaa ttggaaaaat aattggttgg aatggtagag tcagtgatta
     4921 tggggagaat gaggaattta gatttaatat aagttggtgc tatggcagtc ttggaatggc
     4981 aagagtacta tataatatag cgaaaatcat tgatagtcag aaattacgag aaatggcgat
     5041 ggatgtattt acttcatcta ttgattacct taatagcagt gagattttaa ataatggaat
     5101 ttgtcatgga cggtctggaa taatgctttt gttcaatttg atgtatttag atacaggaaa
     5161 gacacaattt aaagcaattt ctgataattt atttaaagaa attataaatg atgcttctaa
     5221 ttctgagtat atatttgtgg agcgtgacat atattttaga ggcgtaacct ttgatgaagt
     5281 tattgattat attgactttg gattgctaaa tggtgtttca gggatagtta taactctaat
     5341 ggcacaaagg actggaaatg cctacccatt ggatagaatg ctgtttatgc agtgaagttt
     5401 ttaagttaaa ggagaagtat gagaaaaatc ttaaaaaaca aactatatct aaaagttctg
     5461 gtttcggatt tgatatcaaa ttttggagat acattatact ttatagctct catgacctat
     5521 gttacggaga ttaaggatag taatttagct atttcaatcg tcaatatatc ggaaactcta
     5581 cctattttat ttacaatatt ttttggtatc attgcagata aaacgcttaa taaagtgaaa
     5641 atgattatta aaacgttatg gctacgggta ctgctatatt tattggttgc tgtggctatg
     5701 aattttaaac cttctattat gatagtcata attgctagtc tcgttaatct tgttgcagat
     5761 acattgggac aatttgaaaa tggtcttttt tatccaattt ctaatcgaat agtgaaaaag
     5821 tcagatagag aagaaactat ggcgtttagg caaactgttg tttctgtgat gaatattata
     5881 aatcaatcat tgggtgcgtt tttaattact ttttttagtt tttctcactt agcatttata
     5941 aatgctctaa cttttgctat tagtctgtta attatgttag caatcaaaaa tcaaattaat
     6001 agctattatg acgagacgat ctcgacaagt aagatatcac aatttgactt taaagcttca
     6061 ttttctgaga ttacttcaaa tttaaagctc tcgattaacc atctatttag tatcggcaac
     6121 atgaaggaag ctttacttgt tataccaatt cttaatggga gtttggcaat tctcacgcca
     6181 ttagttgttg ttgatctttc taaagattct aatttgacaa ttattaattc agcgattacg
     6241 atctcgcttt taggaattag cactgtttca ggaggaatac ttgggggcac tttaattcta
     6301 attagtaaaa aatttaaaag cctttccata ggcactttgc taaaaatgaa tttaacgact
     6361 gttttactat cattcgttgc tttttacttc caaaatattt atttaattat attatcatca
     6421 tttctttcga gtgtattagt tagtgcatta aatcctaaaa tggggactat catatttaat
     6481 aatattgatg agacgaagtt ggctacaata tttggaggaa tggtgacata tttccaaata
     6541 ggggatattg tgtcaaggtt attgttttct accttagtga tttacttacc gtatggttat
     6601 atcgcattaa tatatatagc agttgttttt gtggcaattt tatatacatt aaaaagttca
     6661 aatcacatag aaagggaatt ttaaattagt taaatgatta tagttttcca aattttctac
     6721 tattgaaaac ctattttcaa gattgagtac taaagttcga gattttgttc gtactcagct
     6781 tagagaattt caatatttgg atgatgggca atttaaaaca ttaccagagt atccagaatt
     6841 tgcttggttt gaagggatgt aaatgcggta actcatagaa attgctccat ttttggcgat
     6901 tatatccgaa ttatgatgtt tgatgatcga ttagaaattc atagtccagg taagcttcct
     6961 aatatcgtaa cggttgaaaa tattaagcac gaacgttttt ctcgtaatcc tcgtattgct
     7021 agaactttaa cagaatttgg atgggtacga gaaatgaatg agggagtgaa gcgaatctat
     7081 tctgagatgg aatcttattt cttgcatgaa cctaaataca cagagccagg aaataaagtt
     7141 gttttaactc ttgaaaataa tattttgagc cgacatttga gagttaatga taagatgatg
     7201 aaaaaatatg acgaattcaa tgatttaaat gacgatgaga aagcaatttt acatatcatg
     7261 tataataccg gagagaaaat gactactgct ttggccgcta gaataacaaa taggggtaga
     7321 aattttgcaa gtaaattatt aaagagtctt gtaaataaag agatcctgga atggcatggc
     7381 acaagtaagc aagatagaaa tcagtactat actttggcag aatagcggat ctatttataa
     7441 ctggagtgca gaagagtgca gtagttcgga gtaaaacgca gtaagtgaat ttcccctgtt
     7501 ttcctcaaaa aatctcaaac tttttgaaat tctggacaaa agaaaaggcc tagttgcctg
     7561 tagtttctac ctattaagtt atattgaaat tcattggttt aaaaccagat cttaagaaag
     7621 ctcgtaaagc ttcacaattc tcaaaacgtt aatcaatacg attatatcaa tgtttcaaga
     7681 cattcaagag ttatctcttg ggtgtctttt tttattcaaa attcgatagt ttccaccaaa
     7741 gtttccacca attttccacc attatttttt caagctacga aatgcaatat cgcctactgt
     7801 ccgattaact atatcttttg tatttacata agtctttgta atttgcttat cactatgagt
     7861 tagagcttct gaaatagctt caagagaata acctgcttgt ttggcaagag taacacctgc
     7921 atgtcttagt ttgtgtggtg atgctggtgc aagttctgga tgtctccgtc tgactgactt
     7981 cattctataa tttagataat ccacgtgaag aggtaaatta atgttgtttg aacgatcatt
     8041 ataggtgaat acaaactgct tttgagtttg acgcaatcca aataatttta actcctcttg
     8101 ttgtcttgct ttccaattag ctaatagctc aattaattca ataggtgttt taaaaagggt
     8161 cttcttacga cctttggtgg gttttatatt tccgaaacga tctaaagctt gttctatcag
     8221 tgtttctcca gtagagaaat tgatgtgttt ccattgaaga gcataacttt ctgattttct
     8281 atcggataaa aagaatgtcg tataaaagag agtgtagtct tttaaatcaa taagtccttt
     8341 ctctaagtct atgtcaaaag cttgtaatca taatttcagc tcttctttat cgagagataa
     8401 atcttcctct cgtttgcttt ctttaaggag aatcttttta ttagctttaa ttctagtaat
     8461 tgttttgcgg agtttatttg atggaatata ttctagttcc tcagcccaat cgaaaacaga
     8521 attaacatag ctcctaatta ctttgaaatt agcatagcta tttgctttgg gagtaagtaa
     8581 tgaaagaata agttgtttat tattatttgg gtattcgata gaatatttac ccagaatggg
     8641 taaaatgtgt agcctgaata tattttctgt ttggaaaact gttgcttttg tgggtggttt
     8701 tattgttgtt gtggtttgac ctgctttgta tggttcgagc caaatatctt cataaaattt
     8761 tttgaatatg atttctcctt tattttttat gtttatatgg ctttttccag acttagcatt
     8821 tttaatgtcg atagaaagtt ttaattctac ttctttggct tctcgtctgg ttttatattt
     8881 tctttcaaaa agtttaccta aacccaattt tgcttgaaca tcttctggaa tgtaaagtcg
     8941 taattgatat gttccatttt ttgttttctt aatagacata tttacctcct tatgcgctga
     9001 tttctaatct tgtcatccat tgattgatac ttttcttgtt gaaacgaata gattttccga
     9061 ttcggatata gggtaatccc attgcaatcc caatatcaag tgtattatta gagataccta
     9121 ggtagttgta agtctgtttt ttgtttagaa aagtgctgtc agccccaata tcctctttaa
     9181 aatgatgaat ttcattcttt attagtgttg caatcatttg ctgaatttct tgagtttgtt
     9241 cttctggcaa ttgtactagc atatattatt ctcctcttaa aaataaaaaa gaagagtaaa
     9301 atactctcct gctgttaaaa agattaattc ttcttattta ttattttgtt gaaaaaaact
     9361 agcaaagcga ccccgaccac tgtcaattgt ttgcccttat tacgacatgc atcacaaatt
     9421 ggtattgttt taggtgatga gattgttttt ttacaagttt tacacttctt cgtttttagt
     9481 gtcatttttt tctccgtttc gatttttgct gtttcggtat tgcttaagtt aacgttacta
     9541 tcttggtgga attcaattaa tttagtatta atattaataa ataagtccct attgtttttt
     9601 gagtagctgt aatgattatg aattaattct aacaaactta cttttgggat actattattc
     9661 tttatccatt ttaattcttt tacataaaga agtttttttg ctagttcttt caaataattt
     9721 gttttgtatg gaatattttg tttagaaact aattccatcg aaccttgaaa agatagtagc
     9781 cgatcatggg ctatcccctc attatttagt gttaaatcga tataaatttg cataccaaca
     9841 attttagtca taatttctat gtcttgaagt aaaaaatcag catgtgtttg taaagaggct
     9901 tgacggtatg ttggttggct gattttctta ataatttcat ctctatttga aattatatca
     9961 gatttaatag cacttactga ttcttcaaat aatgtatttg catcctttag tgacttaact
    10021 ttttctctga aatctttgct attgttggct tctataactt ttgtacgagc tgaataaaat
    10081 ggagctagta tactattatt tctttcccat ctaatctgat aatcttgatt ttctttgata
    10141 tctaacagta agttatagat ttgtttaagt tgagcttgag cgattagatc actaggaact
    10201 tgattttcgt tgttattagt cattttcctt aatgtcaaat cttcaacacg attcttctga
    10261 tcggttgtgt ctacaattac agccctaaga tttccttcta cttttctaga ttccccaatt
    10321 ttataagcgc cctcttgaag tttcgctttg gtgtcaggag atagactgtc aaagtcaacc
    10381 tcatatagag tagcattatt gaaatctagt attttagtgt taggattaag atattggttt
    10441 gaaaagttga atggaggggt tcctttagta tcaaataagt ttaagatatc aaatgggaaa
    10501 ctttctttaa tcatgttggg gagagcttgt tcaaaaggac tacttatttc aaagatatct
    10561 gttgttttga tatctgtctc atttttaaat aaatcaaaag attgtaagtt tttttgattg
    10621 attcttcttt ttgcttttct gatttagcaa cttcgttcat tagatcacct agtcattttt
    10681 gtattaatta taacatttag tattgatttt aaacgtatct aaattaataa tactaaaaat
    10741 taatattatt aaaaccatca tcagtgtcca atgacataag taatttgttt tgctgtttct
    10801 gcatcaaaag tgcggtagct aacgactcct agtcctttga tatttgattc agagatgagg
    10861 atggagccat ctgatttgac ttgttccaca aaggcgatgt ggccataagt tggatctgct
    10921 ccagcttgcc ctgggctaaa agatagagcg gagtgttcgg ttggggtatg agttgtctga
    10981 taccctgggg cattcatcca ttggccacca tttcccatat actttccgaa gctaacaccg
    11041 acttcttttc ctcggttata gacaaaccag gtacattgtc cccaaggata agacagtcct
    11101 gtgtggcttg aggtattgat ttctttggtg aggctatagc cttgtgggac atcccctgtt
    11161 gtgacaccgc ctccgtctct ggtttttcct ttcgtctgtt caggggcttt tggtgtacct
    11221 ccatgctcat cgatataggt atcgagtttt tgcatggttt cagcacgccc tttcctagag
    11281 ccagaggtat cggtgaagta gacgccacca tctgttgacg tgttgagaga accactcgca
    11341 aatttttgcg ctttgtcatc ttggactttt aaggtttcat ttttattgcc aatgatggtc
    11401 tgctttgtga gtccaacaac ggctacttca tcgttaaaat tattggcatt ttctggatta
    11461 gagtcaaatg cggttctgtt gcaaagtttt aaataaagaa taaaatccct tacggtatct
    11521 atgatttaag ctgggattcc caataatacc ttgatttcag tacagaccga aaacccgaag
    11581 agagtgcctt cttttcgagt tttcttatat aatcctcgga tggcttccat gcctttaatc
    11641 gtggtagagg cagtgcgtaa acttcgatag aatttattgt gtctctttac tggacgatgg
    11701 tcttgttcaa tcaaattatt caggtattta atggtacaat gttctgtccc ttgataaaag
    11761 ccccgtattc tcttagtttc ttaaaggcac ttgtaataga gggggcttta tctgtgacta
    11821 caaccttcgg ttcatcaaac tgcttaacta accgctcaag aaaagcatag gctgtttgtg
    11881 tgtcccgttt tttacgtaac caaatatcca aggttaaacc atctgcatcg atggctcgat
    11941 acaaataatg ccattttcct ttaattttga tgtatatttc atccattttc catgaataaa
    12001 aggatttttt atttttcttt ttccaaattt gatagagtag tttgccatat tcttgcaccc
    12061 aatgataaat cgtcgtatga gaaacgttaa tgccacgatc atataagatt tcttgaactt
    12121 cacgatagct aaggttataa cgaagataat agcccacggt tacaataatc acatcctgct
    12181 gaaattgctt tcctttaaaa tgatttatcg tcattcctcc tgctatcttt ttctattatt
    12241 ctacctgatt tgatagtaga tttaaaactt tgcaacagaa ccgatgtaac cgtttattaa
    12301 tcttttttat catctatgga taacattttt ttgttacact aggagtatga aaaaggagat
    12361 atgatgaaac agagccaagc taaaaagcat gacaatacga tgactaataa gattttgatg
    12421 aggttgattg ctcttgtctt aggtttgctt tttcttgaaa ttttgattat tcatagtaaa
    12481 aatgagcagc aaaagagtgt ttcaaatcaa gtacagacag cacgtatcat ggctaatggg
    12541 gacttgcttt atcatgacgg tctctatatg agtgccttgc aggcagatgg cagttatgat
    12601 tttactgaaa attttacata tgtgaagcca tggttaaagc aggctgattt ggtcttgggt
    12661 gattttgagg gaactatcaa tcctgattat cctttgtcag gctaccctct gtttaatgct
    12721 cctcaatcag tgacggcagc tattagtgat gccggctatg atgttatgga tttggcccat
    12781 aatcatattt tggactctgg tttagaggga gcttttacaa cagccgatgc atttaaagag
    12841 gtgggcattg accctgttgg tgtttatgaa aatcctgtgc gtgataaggc gcctctgttt
    12901 atcaagaatg ttaatggcat caaggtggca atactttctt atgcctatgg tttcaatggc
    12961 ttggagtcaa atctgaccga aaaagagatt gcgaatcatt tgtcgaatct tgatgaaaaa
    13021 cggatgaaag tagagattga gcgtgctgaa aaagaggctg acgttacggt tattatgcca
    13081 cagatgggcg tggaatatcg tttggaaccg acagatgaac aggtaaagct ttaccataag
    13141 atgattgatt ggggtgctga tattatcttt gggggccacc ctcatgtggt tgagccgtct
    13201 gaagtggtta aaaaggatgg acagcaaaaa ctcattattt actcaatggg gaatttcatc
    13261 tctaaccagc gcatagagac tatggatggt gtggatagtg cagcatggac agagaggggc
    13321 gtcttaatgg atgtcactct tgagaaaaag aattgtcaaa ccacgattaa gacagctcaa
    13381 gcgcatccaa cctgggttaa ccgcacaccc aagggaacaa tttcgccaga gggatatcct
    13441 ttatatactt atcaaaccta tattttagag gatttcatta aaggtggaaa atacagaaat
    13501 aaactagatg aagaaactaa agagcgtata gatactgcct ataaagaaat gaatgctcat
    13561 gttaatctaa aatggaaata aagctaagat atcgctaaaa tttggcgata tttttcttta
    13621 tcgacaagtt accaacagac ttatccacag gtgtggataa gtctgttctc agtgttaaac
    13681 cttgattttt caaggtttta ttagaattgt attgttttac ttgttaacaa gtttatccac
    13741 aagttgttga attgatagag actgaatttt ataaacgata ctggttaaat gttgtagaaa
    13801 cattcgtttt tttcaataaa aaaggtgtaa tttctataaa aaatagcgtt tttaatcaaa
    13861 atatgctaaa attatataaa ataaaatgat ggaggcttct catgaaagcg attattacag
    13921 ttgtaggtaa ggataaagcg ggtattgttg caggtgttgc gactaagatc gcagaacttg
    13981 gtttgaatat tgatgatatc actcaaacaa tccttgatga attctttacc atgatggcgg
    14041 ttgtatcatc ggaagataag aaagatttta cacacctacg tgctgaatta gaagcttttg
    14101 gtgaatcatt aaacgtcaaa atcaatatcc aaagctcagc gatttttgat gctatgcaca
    14161 acttataaga taggggtagt tgaaaatgga tattaaacag gttacagaaa ccattgctat
    14221 gattgaggag cagaactttg atgttcgtac tatcaccatg ggaatttcac ttctagactg
    14281 tatcgattca gatattgata aggcagcaga aaaggtatac aacaagattg tttctaaggc
    14341 taagaacttg gtagctgttg gtgacgaaat tgcggctgaa cttggtattc caattgttaa
    14401 taaacgtgtt tctgttactc cgatttcaat tatcggtgcg gcgacagatg cgacagatta
    14461 tgtaccgttt gctagggcac tagaccgtgc agctaaggaa attggcatta actttattgg
    14521 tggtttctct gcattagttc aaaagggcta ccaaaaaggt gatgagattc ttattgattc
    14581 tatcccacgt gcgcttgctg agactgattt tgtctgctca tctgttaata ttggttcaac
    14641 aaaaactggt attaacatga cagcggtacg tgatatggga cgtatcatta aagaggcttc
    14701 tgaggcagat ccaatgggtc caggtaaatt ggttgtcttt gctaatgcgg ttgaagataa
    14761 tccatttatg gcaggtgcct tccacggtgt tggtgaggct gacgttgtaa tcaatgttgg
    14821 ggtttcaggt cctggtgttg tgcaacgtgc tgttgagaag gtttcaggtg aaagttttga
    14881 tgttttagct gaaacagtta agaaaactgc ctttaaaatc acacgtgtag ggcagttggt
    14941 tggtcaaatg gctagcgaac gtctaggtgt cgagtttggt attgtagact tgtctcttgc
    15001 accaactcca gcagtaggtg attcggtagc tcgtgtactt gaagccatgg ggcttgaagt
    15061 tgttggtacg catggtacta ctgcggctct agctcttctt aatgaccaag ttaaaaaagg
    15121 tggtatcatg gcatgtaacc aggtcggtgg tttgtcaggt gcctttatcc cagtttctga
    15181 agatgaagga atgattgcag cagttcaatc tgggcatatc aaccttgaaa aattggaagc
    15241 catgacggct atctgttctg ttggtctaga catgattgcc attcctgctg atacgccaga
    15301 tacaacaatt gcggccatga ttgccgatga agcggctatt ggtgtcatta atcagaaaac
    15361 aacagctgtt cgtattattc cttatggtaa ggaag
//
