LOCUS       c00010_JAHDUT0..       11700 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHDUT010000018.1 Streptococcus thermophilus strain Nect13
            Contig_18, whole genome shotgun sequence.
ACCESSION   JAHDUT010000018
VERSION     JAHDUT010000018
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:39:36
            Original ID  :: JAHDUT010000018.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11700
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11700
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[482:1700](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      483..1700
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11700
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11700
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /tool="antismash"
     CDS             251..400
                     /locus_tag="ctg10_1"
                     /transl_table=11
                     /translation="MQVSDAIAQIELAEEEVVSSGLSIDIMEIKPSVATELIDGLKGRC
                     PPSV"
     CDS             483..1700
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Streptide_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_2"
                     /sec_met_domain="PF04055 (E-value: 2.1e-21, bitscore: 70.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.8e-10, bitscore: 32.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.3e-11, bitscore:
                     37.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 6e-09, bitscore: 29.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 4.9e-16, bitscore:
                     52.4, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSNVYSIFFNWYNKQGILRNNRNNKLFSLNLATFLALKFMYQFS
                     LKKFSDSKSQVIKNVIDFLNNNEISLSKTNTKIVEFSTKIPLKVIQIEVTNKCNLRCMH
                     CYLPDYSKELDRKKISSIVYEAKQLGVMDVDFTGGEPLLLQGLSEIIEEVLKEGMCTTI
                     FTNAVYIPEDFKILIQRYDGIRLKVSLDGWNETIHDSIRGRGTFKRTIKNIEYFRSLGV
                     PVTVNVVLNNKNISGVKYFLELFDRLDVKYAFDRFLPFERNNRLSISDEEFNNAILCIP
                     NIQANCNNISESTFESFYCGAGNSYVFINSSGDVGFCPTLSSTKFCGGNINEKTLNDIW
                     INSKFFNHIRNVRCKYYNECPANYVCQGGCRSRAQFFGGSIGSPDIQECKLAYNLTGIK
                     PKSMSL"
     CDS             1697..2440
                     /locus_tag="ctg10_3"
                     /transl_table=11
                     /translation="MKILSIIYDGGSRIPGARFAPTKYYQEAMLYDRKDSDIITINLGN
                     QDLFSIDLESLSRTIAESKVQIALGGDHSVTYLLAKATVREGAYLIVLDAHLDYFKDFE
                     SVVKNWNFLSFLTDIFEKIIIIGERNFEFPSSFDNKIIILSMEEYWLNKSRVLKKLDSY
                     IDESKDIYLSIDIDVLDPSVFDSVSYPIIGGFQMNDFLGIISKILCSDKVYFCDIVECN
                     PMVGSDNAHIFYQMIQFVKSKLRRI"
     CDS             2447..3619
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 61.4; E-value: 1.2e-18)"
                     /gene_kind="transport"
                     /locus_tag="ctg10_4"
                     /transl_table=11
                     /translation="LKIKKYAALSIYFNRFSSLISEYGYTILINILLSRISVQLVMYFW
                     VVKCLAAIVTNRINISNSKLSRKYLLILLEITKAILLFLLGFGLNHIIVLLVVFIIEVV
                     NVLFSSLLYSCVPIIIDKDSLIKFNARYTSIGSVSYFLAPLFVGLFINKSHFLLFAVYA
                     LLLIVGATSLLFLPNISTLNLKEERKKQNLNITLFNILRSKKIALVLLSGVIVGSIGVV
                     YDTYEVVYLTKYLGISDSMYSFSLSFLAVSFLVMSFLLSFVKQISSHMKAFALGLSFYV
                     LYLLLFSTSSNIYTVLMSYVFLAIGQTMMGIIETNYFQLSLNMKELQKLYIYSETLHSV
                     FSGIAVLVIGSFAFLSSHLVLVFRSLAVFALFILLCYCVFVNLKKLSIDK"
     CDS             3873..5549
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 503.4;
                     E-value: 1.4e-152)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_5"
                     /transl_table=11
                     /translation="MSEEKQLYGADLVVDSLINHDVEYVFGIPGAKIDRVFDTLEDKGP
                     ELIVARHEQNAAFMAQGVGRITGKPGVVLVTSGPGVSNLATGLVTATDEGDPVLAIGGQ
                     VKRADLLKRAHQSMNNVAMLEPITKYAAEVHDANTLSETVANAYRHAKSGKPGASFISI
                     PQDVTDAPVSVKAIKPMTDPKLGSASVSDINYLAQAIKNAVLPVFLLGNGASSEAVTYS
                     IRQILKHVKLPVVETFQGAGIVSRDLEEDTFFGRVGLFRNQPGDMLLKKSDLVIAIGYD
                     PIEYEARNWNAEISARIIVIDVEPAEVDTYFQPERELIGNVEASLNLLLPAIQGYKLPE
                     GSVEYLKGLKNNVVEDVKFDRQPDEGTVHPLDLIEVLQEQTDDDMTVTVDVGSHYIWMA
                     RYFKSYEPRHLLFSNGMQTLGVALPWAISAALVRPKTKVISVSGDGGFLFSAQELETAV
                     RLKLPIVHIIWNDGHYNMVEFQEEMKYGRSSGVDFGPVDFVKYAESFGAKGYRATSKAA
                     FASLLQEALTQAVDGPVLIDVPIDYKDNIKLGETILPDEFY"
     CDS             5565..6284
                     /locus_tag="ctg10_6"
                     /transl_table=11
                     /translation="MSEAIKLFQYNTLGALMAGLYGGTLTVGELLEHGDLGLGTLDSID
                     GELIVLDGKAYQAKGSEGKVEVVEVSPDEKVPYAAVVPHQAEVIFRQRYEMTDKELEDR
                     IESYYDGVNLFRSIKIKGHFKHMHVRMIPKSNADIKFADVATRQPEYEVDDISGTIVGI
                     WTPEMFHGVSVAGYHLHFISDDLTFGGHVIDFVIENGIIEVGPVDQLDQRFPVQDRQYL
                     FAKFNVDEMRKDITKAE"
     CDS             6372..6488
                     /locus_tag="ctg10_7"
                     /transl_table=11
                     /translation="MNVQSDEDTLLKVDEVSKTEAQAFDVFDQTISRFKFRV"
     CDS             complement(6704..7594)
                     /gene_functions="other (smcogs) SMCOG1206:transposase
                     (Score: 312.3; E-value: 7.8e-95)"
                     /gene_kind="other"
                     /locus_tag="ctg10_8"
                     /transl_table=11
                     /translation="MRLIKNNTELIGIKDQNIKISLVFETDTHIEIQAKLDYPAPSCPH
                     CHGKMIKYDFQKPSKIPLLEQAGTPTLLRLKKRRFQCKSCRRVTVAETSIVEKNCQISN
                     LVRQKVTQLLTEKVSLTDIARRLRVSTSTVYRKLDQFTFKEHYDKLPAVMSWDEFGFKK
                     GELAFVAQNYETNQLITILDNRRQTTIRNYFLKYPLKVRQQVQFITMDMSGAYIPLARK
                     LFPNAKIVLDRFHIIQHLGRAFLKTRIAIMNQFDKKSLPYRALKNHWRLFQKDSRKLIS
                     QLFLFKDFPPNFSTT"
     CDS             complement(7851..8555)
                     /locus_tag="ctg10_9"
                     /transl_table=11
                     /translation="LTEKGIIISEKLADLAGISVGDEVTVQNSQDKDIKLKVAGISEMY
                     MGYFIFMNESTYKDAFGKEASQNATILTLKDHSDKNVEQTASRFMSLDGVKGDVQNTTL
                     KAQIKTIVNSLSRVMGVLISVSILLAFVVLFNLTNINVAERIRELSTIKVLGFFNKEVT
                     LYIYRETICLSIIGILVEFGLGLGLHQYMVDVIPPENIMFNPNLGWLIYAVPTLVIIII
                     LTGSGYLCEPTP"
     CDS             8807..9529
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     76.2; E-value: 4.9e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_10"
                     /transl_table=11
                     /translation="LRGRVSSYLADFSKLDNVYRFVEEIKRDFQRIDILFNNAGLYAGK
                     ERKASGENVELTFMLSVLVPYIFITELIPLLEKLPDGLVINTSSYMHHFAKVKDLDFGF
                     EKEYNPGLAYNNSKLYTIWMTRYLARDFFLKGSNTTINAYHLGLILTNLGNNSSDKKTE
                     KSLFGRLMKSLSKDLDQGIETGYYLTLSEEVSGLTGYYFDEKKVKSVSEKGYSFEKTQK
                     LMNYCQEKVKMFKEKQNV"
     CDS             complement(9706..9918)
                     /locus_tag="ctg10_11"
                     /transl_table=11
                     /translation="MLLLILLGIFTAFLSLAFALLHLMASLSELRKHKNTLGNRLLLIG
                     SNLATFSHPLLPFADCCFIPLADRS"
     CDS             complement(9957..10532)
                     /locus_tag="ctg10_12"
                     /transl_table=11
                     /translation="VYVTEQFVHSVHMTAQDRRITKTRKAIYQAFLYLLNQKDYEAITV
                     QEIIDLADVGRSTFYSHYESKELLLDELCQKLFHHLFERTQYLSPQDYLAHIFQHFKKN
                     QDHVTSLLLSKNDYFIRQLRKELEHDVYPMVADELIQSHPNIPHSYLKHLVITNFIETL
                     TWWLKKGKSYSEQEVVQFYLEILNVASN"
     CDS             10630..11526
                     /locus_tag="ctg10_13"
                     /transl_table=11
                     /translation="MSSKYAVWLAFFLNLSFSIVEFIAGGIFVSSAVLADSVHDLGDAL
                     AIGLSAFLETISNREEDSRYTLGYKRFSLLGALVTAVILMTGSGMVILENISKLFHPQP
                     VNDEGLLWLGIIAISVNLLASLVIRKGQTKNESILSLHFLEDTLGWLAVILMAIVLRFT
                     DWYILDPLLSLAISFFILSKAIPRFWSTLKIFLDAVPEGVDIKQVKNDLEQLDNVASIN
                     QLNLWTMDGLEKNAIVHVCLEHVKHIEVCKESIRDLLKESGFQNVTIEVDEDLATHQAH
                     KRNIEELEAESEQQHHH"
ORIGIN
        1 gcaaggaagt taagtagttc tgtggtaaac ggagtcatag gaataaatct ctttctagta
       61 atgttttgca actctactat aacggattta ttcctttttg tgtttacaca acttatttta
      121 cactacctgc aaatcagttt aataagacaa tttcaaagca ttttcagcta aattttatag
      181 ataaagaatg atttctatga tttgttatgg gtacttattg attcttaaat aaataatgga
      241 ggatattacg atgcaagtta gtgatgctat tgcacaaatt gaattagcag aagaagaagt
      301 tgtttctagc ggtctatcta ttgacattat ggaaattaaa ccttctgttg ctacagagtt
      361 gattgatgga ctcaaaggtc gttgcccacc gtctgtctaa tagaactgat tgtaggatta
      421 gagtctattt ctaatccttt ggtttttata ttaatatttt tggaagattg cagggaatta
      481 atatgacgag caatgtttac tcgatttttt ttaattggta caataagcaa ggaatactca
      541 ggaataatag gaataataaa ctattttcat taaatttagc tacattttta gctttaaaat
      601 ttatgtacca attttcattg aaaaagtttt ctgattcaaa gagtcaggta ataaaaaatg
      661 ttatagattt tctaaataac aatgaaatat cactctctaa gaccaacact aaaattgttg
      721 aattttcaac gaaaatacca ttaaaagtga tacagattga ggtcacgaac aaatgtaacc
      781 taagatgtat gcattgttat ttacctgatt attcaaagga gctcgataga aagaaaattt
      841 caagtatagt atatgaagct aagcagctag gagtaatgga tgttgatttc actggaggcg
      901 aaccattatt attacaggga ttaagtgaaa ttatcgagga agtattaaaa gagggaatgt
      961 gtacaacaat ttttacaaat gctgtatata ttcctgaaga ttttaaaata ttgattcaaa
     1021 gatatgatgg tataagacta aaagttagtt tagatggttg gaatgaaaca atacatgatt
     1081 caattagagg aagaggtaca tttaagagaa caattaagaa tattgaatat tttaggagtt
     1141 taggagtacc tgttactgtt aatgttgttt tgaataacaa gaatattagt ggagtgaagt
     1201 attttttgga gttgtttgat cgattagatg tgaaatatgc ttttgatagg tttttacctt
     1261 ttgaaaggaa taatcgacta tcaattagtg atgaagaatt caataatgct attttgtgta
     1321 ttcccaatat tcaagcaaat tgtaataata tatccgaatc cacatttgaa tcattttatt
     1381 gtggtgctgg caattcttat gtgtttataa attcgtcagg tgatgttgga ttttgtccga
     1441 cattatcctc cactaaattt tgcggaggta acattaatga aaagacttta aatgatattt
     1501 ggattaattc gaagttcttc aatcatattc gaaatgtacg atgtaagtat tataatgaat
     1561 gccctgcaaa ttatgtttgt caaggtgggt gtagaagtcg agctcagttt ttcggaggtt
     1621 ctattgggag tcccgatata caggagtgca agttagcata taatttaact gggattaagc
     1681 caaagtcaat gagtttatga aaatattatc tattatttat gatggtggaa gtagaattcc
     1741 aggagcgaga tttgctccca caaaatatta tcaagaagcg atgttatatg ataggaaaga
     1801 ttctgatata attacaatta atttaggtaa tcaagattta ttttctattg atttagaaag
     1861 tctaagtcga actattgctg aatctaaagt tcagattgct ttaggaggag atcattcagt
     1921 tacttatcta ttagcaaagg ccactgttcg agagggagca tatttaattg ttttagatgc
     1981 tcatttagat tacttcaaag actttgaaag tgttgtaaaa aattggaatt ttttaagttt
     2041 tttaaccgat atttttgaaa aaataattat cattggggaa aggaattttg agtttcctag
     2101 ttcatttgat aataaaataa tcatcctctc aatggaggag tattggttaa ataagagtag
     2161 agttttgaaa aagttagata gttatattga tgagtcaaaa gatatttact tatcaataga
     2221 cattgatgtt ttggatccat ctgtttttga ttcagtatca tatcctatta ttggaggatt
     2281 tcaaatgaac gattttcttg gaataatttc caaaatttta tgttctgata aggtatattt
     2341 ttgtgatata gttgagtgca atccgatggt tggaagtgat aatgctcaca ttttttacca
     2401 aatgattcaa tttgttaaat caaaattaag gaggatatag gaaatattga aaataaaaaa
     2461 atatgcagca ttgagtattt attttaatcg tttctcatcg ttaatctcag agtatggtta
     2521 tactatcttg atcaacattc tattgtctag aatttctgtg caattagtta tgtatttttg
     2581 ggtggtaaag tgtttagctg caatagttac aaataggatt aatatctcaa atagtaaact
     2641 gagcagaaaa tacctgctta ttctgttaga aattacaaag gcaatcttac ttttcttact
     2701 aggttttgga ttaaaccata taattgtcct attagttgta ttcataattg aggttgtcaa
     2761 tgtattgttt tccagtttat tatatagttg tgtaccaatt attatagaca aggattcatt
     2821 gattaagttt aacgctaggt atacaagcat tggttcagta tcttattttt tagcaccgtt
     2881 gtttgttggt ttatttatta ataaaagtca ctttttattg tttgcagttt atgctcttct
     2941 tttgatagtg ggagctacta gtcttttatt tttaccaaat atttcgactt taaatttgaa
     3001 agaagaaaga aaaaaacaaa atttaaacat tacattattt aacattctga gatccaaaaa
     3061 aattgcatta gttctattat ctggagttat tgtgggatca attggagttg tttatgatac
     3121 ttatgaagtt gtttatttaa caaagtatct cggtattagt gattctatgt attccttttc
     3181 cttatcattt ttagcagttt cattcttagt aatgagcttc cttcttagct tcgtgaaaca
     3241 aataagttct catatgaaag ctttcgcctt aggtctttca ttttatgttc tatatctact
     3301 tttatttagt acatcttcga acatttatac agtactaatg agttatgttt ttctagcgat
     3361 aggtcagaca atgatgggga taatcgaaac caattatttt cagttgtcac ttaacatgaa
     3421 agaattacag aaactatata tttactcgga gaccttacat tctgtatttt caggcattgc
     3481 tgttttagta ataggaagtt ttgccttttt aagtagtcat cttgttttag ttttcagaag
     3541 tcttgctgtt tttgctctgt ttattcttct gtgttattgt gtgtttgtaa acctcaaaaa
     3601 actaagcatt gataagtaat atttataaat cagaaaacaa gcaaatgaga tagttaatct
     3661 ataaagtaga caaacgctat tttgagtgtt tgtctttttt tagtcaccta gtctgccttt
     3721 tttcacaaga ttgtctgaaa actgtgctat aatgataaca gaattgtgaa ttgatgaaag
     3781 tttgtgaaaa aacgagcaga ctttgacact ttgtgactta tacttgaaag gaaagttggc
     3841 tctaccattt tagggctaga aggactgtgt tcatgtcaga agaaaagcaa ttgtatggtg
     3901 cagatttagt ggttgatagt ttgatcaacc atgatgttga gtatgtcttt gggattccag
     3961 gcgcaaaaat cgatagggtt tttgatacct tggaagataa gggacctgaa ttgattgttg
     4021 cccgtcatga gcaaaatgct gcttttatgg ctcaaggtgt tggacgtatt actgggaaac
     4081 caggtgtagt attggtaaca tctggtccag gtgtctccaa tttggctact ggtttggtaa
     4141 cagcgacgga tgaaggagac cctgttcttg ctattggtgg tcaggttaag cgtgcagatc
     4201 tcttgaaacg tgcccaccaa tcaatgaata acgttgctat gcttgagcca attaccaaat
     4261 atgctgctga agtacatgat gctaacaccc tttctgaaac ggttgctaat gcctatcgtc
     4321 acgctaagtc agggaaacca ggtgcaagct tcatttcaat tcctcaagac gtgacggatg
     4381 ctccggtcag tgttaaggct attaagccta tgacagatcc aaaacttggt tcagcatctg
     4441 tttctgatat taactatctc gcacaagcca ttaaaaatgc agtgttgcca gtctttcttt
     4501 tggggaatgg tgcctcatca gaagccgtaa cttactctat tcgccaaatt ttgaagcatg
     4561 ttaaattgcc agttgttgaa actttccaag gtgccggtat cgtgtcacgt gaccttgaag
     4621 aagatacttt ctttggtcgt gtaggtcttt tccgtaacca acccggagac atgttgctta
     4681 aaaaatccga cttagttatt gccattggtt atgacccaat cgaatatgaa gcacgtaact
     4741 ggaatgctga aatttcagca cgtatcatcg ttattgatgt tgagccggcc gaggtggaca
     4801 cttacttcca accggaacgt gaattgattg gtaatgtaga agcgagctta aacttgcttt
     4861 tgcccgctat tcaaggttat aaattgcctg aaggttcggt tgaatatctt aaaggtttga
     4921 aaaacaatgt tgttgaggat gttaagtttg accgtcagcc tgatgaaggt acggtgcatc
     4981 cgctagattt aatcgaagtt ttgcaagaac aaacagatga tgatatgact gttacggttg
     5041 atgttggtag tcactatatt tggatggcac gttatttcaa atcgtatgaa ccacgtcatt
     5101 tgcttttctc aaatgggatg caaacgctag gtgttgctct tccatgggct atctctgcag
     5161 ctttggttcg tcctaagaca aaagtgattt ctgtttctgg tgatggtggt ttcctcttct
     5221 cagcacaaga attggaaaca gcagttcgtt tgaaattgcc aattgtccat attatctgga
     5281 acgatggtca ttacaatatg gtggaattcc aggaagaaat gaagtacggt cgttcatctg
     5341 gggttgactt tggtcctgta gattttgtaa aatatgctga gagctttgga gccaaaggtt
     5401 atcgtgcaac aagtaaagca gcatttgcta gcttgcttca agaggctttg actcaggctg
     5461 tagatggacc agtccttatt gatgttccaa ttgactataa agataacatt aaactcggcg
     5521 aaactatttt gccagatgaa ttttactaaa aagagggtgt agacatgtct gaagccataa
     5581 aattatttca atataatact ttgggagcct tgatggctgg gctttatgga ggtactttaa
     5641 ccgttggaga gttgttagag catggagact tgggtctcgg aacattagat tctatcgatg
     5701 gtgagttgat tgttcttgac ggtaaagcct accaagctaa aggctctgaa ggtaaagtcg
     5761 aagtggtaga agtttctcct gatgaaaaag ttccctatgc agcagtcgta cctcaccaag
     5821 ctgaagttat cttccgtcaa cgttatgaaa tgactgataa agaacttgag gatcgtattg
     5881 aatcatacta tgatggggtc aatcttttcc gttcaatcaa aatcaaaggt cattttaaac
     5941 acatgcacgt gcgcatgatt ccaaaatcaa atgcggacat taagtttgct gatgttgcca
     6001 ctcgccaacc tgagtatgag gtagatgata tttcaggtac aatcgttggt atctggacac
     6061 ctgaaatgtt ccacggtgtg agtgttgctg gttaccatct ccattttatt tcagatgact
     6121 tgacattcgg tggtcacgtt atagactttg ttatcgagaa tggtattatt gaagttggac
     6181 cagttgacca actcgatcaa cgcttcccag ttcaagaccg tcaatatctc tttgctaaat
     6241 tcaatgttga tgaaatgcgt aaagatatta ctaaggctga ataagcatat aaataagata
     6301 ctgtctcttt gtcaactata gtgggtgacg aaaagctaat atctagagag ggccggatag
     6361 gtcctctttt tatgaatgtt cagagtgatg aagacacgct tcttaaagtt gatgaagttt
     6421 ctaaaaccga agcccaagcg tttgatgtct ttgatcaaac tattagtcgc ttcaagtttc
     6481 gcgtttgaat agtccgtttc tagtgtgttt ttgatgtatt tgcttgtgtc taagaaaagt
     6541 actaaagaca gtttgaaaat aatgattgac cttgctccta ttttcctcta tcagttcaaa
     6601 gaactcatct actctcttct cctgaaagtg aaaaagcaaa agctgataaa gtgtatagta
     6661 gtcagtaaac tcttttgaaa agactagtgt cttcgcaaca acttcatgtg gtgctaaagt
     6721 ttggcggaaa gtctttgaat aaaaagagtt gagagataag tttacggctg tccttttgga
     6781 agagtcgcca gtgatttttc agggctcgat agggtagtga cttcttatcg aactggttca
     6841 taattgcaat tctagtcttt aaaaaggcac gtccaaggtg ctggatgatg tggaaacgat
     6901 caagaacgat ttttgcgttt ggaaagagct tgcgagccag tggaatataa gctccagaca
     6961 tatccatcgt gataaactgt acctgttgtc ggactttcaa tggatacttc aaaaagtagt
     7021 ttcgtatagt agtttggcgg cgattatcaa ggatggttat gagttggttt gtctcataat
     7081 tctgcgccac aaaagccaat tcccctttct tgaacccaaa ctcatcccag gacataacag
     7141 cagggagttt gtcataatgt tccttgaaag tgaactgatc aagcttacga tagacagtgg
     7201 acgtcgacac gcgaagtctt cttgcaatat cagttagtga caccttctca gttagaagct
     7261 gtgtaacttt ttgtcggact agattggaga tttggcagtt tttctcaacg atagatgtct
     7321 cagctaccgt gactcttcta caacttttac actggaaacg acgttttttc agacgtagta
     7381 gagttggcgt tcccgcttgc tcgagaagag ggattttaga aggcttttga aagtcgtact
     7441 tgatcatctt tccatggcag tgaggacatg atggtgcagg gtaatcgagt tttgcttgaa
     7501 tctcgatatg agtgtcagtt tcaaaaacaa gtgaaatctt gatattttgg tctttgattc
     7561 cgattaattc tgtgttattc ttaataagtc tcataagttc ttcctaatga tggtttggtt
     7621 gcttttcatt atagttctta tgggactttt tgtgtacact caaaaagctc tataatccct
     7681 acagtagttt tacccactac agaaattata gagccaagat actcccctat tcgacatagg
     7741 ggagtatctt gttttaaaac gacgaagtgg tcctaactct tccgttttat ttattaagtt
     7801 atagcatatc tcactcaaca gattttagag cctcgagcat attgactttc ttaaggtgtt
     7861 ggttcacaaa gatacccaga acctgtcaga atgataatga ttactagtgt tggaacagcg
     7921 tagatgagcc agccaagatt tggattgaac ataatatttt caggtgggat aacatctacc
     7981 atgtattgat gcagtcccaa accaagtccg aattcaacca agataccaat gatagaaaga
     8041 caaattgttt ctcgatagat gtagagcgtc acttctttat taaagaaacc tagaacctta
     8101 atggttgata attcgcggat acgctctgcc acattgatat tcgttaaatt gaagagaaca
     8161 acaaaagcaa gaagaataga aacactaatc aaaactccca taacacggct aagtgagttg
     8221 acgatggtct tgatttgtgc ctttagagta gtattttgga catccccttt tacaccatca
     8281 agagacataa atcgactggc tgtttgctca acatttttgt ctgaatgatc tttcagtgta
     8341 agtatcgtag cattttggct agcctctttt ccgaaagcat ccttataagt agattcgttc
     8401 ataaagatga agtaccccat gtacatctca gaaataccag caactttgag tttgatgtct
     8461 ttgtcctggc tattttgaac ggttacttca tcacctacag aaataccagc taggtccgcc
     8521 aatttctctg agataataat gcctttttca gtcaaatcaa gcttctgacc agtttcacga
     8581 tgattgagtt tgatgtaatt ttgaagtgtt ttttgatctt tatcattgac aacaagtgtt
     8641 gtgatatctt gacgatcgtt attacttcct acatctaaca ggtgctacgg acgttatcgg
     8701 taagcatcta gcaaagaaac cgtctagtga aggctatcat atcatcctcc acggtcgcaa
     8761 tcctcaaaag ctggaattgg ctactcagga ggttcgggca gtctccttga gaggcagagt
     8821 gtctagctac ttggctgatt tttcaaaatt agataatgtt tatcgatttg tggaggaaat
     8881 caagcgagac tttcaaagga ttgatatctt atttaacaat gcaggtctgt atgcagggaa
     8941 agagcgaaaa gcgagtggtg aaaatgtcga actaactttc atgttatccg ttctggttcc
     9001 ctatattttt ataacagagc taatcccctt gttagaaaaa ttgcctgatg gccttgttat
     9061 caatacctct tcctatatgc accattttgc gaaagtgaag gatttggact ttggctttga
     9121 gaaagaatac aatcccggtt tggcctacaa taattccaag ctctacacca tttggatgac
     9181 acgctatcta gcaagagatt tctttttaaa aggttcaaat accactatta atgcctacca
     9241 tctcggcttg attttaacca acttagggaa taattctagt gataaaaaga cggaaaagtc
     9301 tctcttcgga cgcttgatga agtctctttc aaaagatcta gatcagggaa tcgaaacagg
     9361 ctattatctc accttatcag aggaagtcag tggcttgact ggctactact ttgatgaaaa
     9421 gaaagtcaag tcggtatctg aaaaaggcta ctcatttgaa aaaacacaga aattaatgaa
     9481 ttactgccaa gaaaaggtca aaatgtttaa agaaaagcag aatgtttaat atcataaata
     9541 taagaaaaaa gctcaagttt tcattaataa aacttgatct tttcttatac aagagttaat
     9601 aaaatcgtaa ttaccagagc gattccgatc cgaatcaggt agtgggctac tagatggaaa
     9661 tttcctttat gcttgccatt ccaataggct ccgtagcaaa tcaagctaac tccgatcagc
     9721 caaaggaata aagcaacaat cggcaaaagg aagtaaagga tgagagaagg tcgcaaggtt
     9781 gcttccgata aggagaagcc gatttcctag agtattcttg tgctttctta attctgaaag
     9841 actggccatt aaatgaagaa gagcaaaagc aagggataag aaagctgtga aaataccaag
     9901 aagaatgaga aggagcatag ttttcctttc tatgatacat gatgtaaagt cgcaccttag
     9961 ttagaagcga cgtttaaaat ctccaaataa aactggacta cttcctgctc gctgtaggac
    10021 ttgccttttt tcaaccacca ggtcagggtt tcaatgaagt tggttataac caggtgcttg
    10081 agatatgagt gaggaatgtt ggggtgtgat tgaatcagtt catcagctac cattggatag
    10141 acgtcatgtt ccagttcttt tcgcagctgc cggataaaat aatcgttttt tgaaagcaag
    10201 agactggtta catggtcttg atttttcttg aaatgttgaa agatatgggc caggtagtct
    10261 tgtggagaga ggtattgagt acgctcaaac aaatggtgaa agagcttttg gcagagctca
    10321 tccagtagta actctttgct ctcataatgg ctgtaaaagg tcgaacgccc cacatcagcc
    10381 aagtcaataa tctcctgaac ggtgatggcc tcataatctt tttggttaag taagtacaag
    10441 aaagcttgat agatggcttt tctagtcttg gtaatgcgac gatcttgtgc agtcatatgg
    10501 acactatgaa caaactgttc agtaacgtac acagcgaacg gtttgcccct atcctttctg
    10561 ttggtagtat tggataatag atattgaata tgatgttcgt gaatctatta taccaaagga
    10621 aggtaaaaaa tgagttcaaa atatgcagtc tggttggctt ttttcttgaa tctaagcttt
    10681 tccattgttg agtttattgc agggggaatc tttgtttcca gtgctgttct cgctgactct
    10741 gtccatgact tgggggatgc tctagccatt ggcctctcgg cctttctaga aacaatctcc
    10801 aatcgtgaag aagatagtcg ctatacccta ggctacaagc gttttagctt attaggggct
    10861 ttggtaacgg cagtcattct gatgacaggg tctggtatgg tgattttaga aaatataagc
    10921 aagcttttcc acccacaacc cgtcaatgac gaagggcttc tttggttggg aattattgct
    10981 atcagtgtca atctgctggc tagtctggtc attcgtaagg gtcagaccaa gaatgagtct
    11041 attctcagcc tgcatttttt ggaagatacc ttaggttggt tggctgtcat cctgatggcc
    11101 attgtcctcc gatttacgga ctggtatatc ctagatcccc tcttgtctct tgctatttcc
    11161 ttctttattc tgtccaaagc cattccacgt ttttggagca cgctcaagat tttcctggat
    11221 gctgtgccag aaggggtaga tatcaagcaa gttaagaatg acttagagca gttggataat
    11281 gttgctagta tcaatcagct taatctttgg accatggacg gcttggagaa aaatgctatt
    11341 gtccatgttt gtctggagca tgtcaaacat atcgaggtct gtaaagagtc tatccgagac
    11401 ttgctcaaag agagtggctt tcaaaatgtc accatcgaag ttgatgaaga cttggcaacc
    11461 caccaagctc acaagcgaaa tatcgaagag ctagaagcag aaagtgagca gcaacaccat
    11521 cattaaggtt tgtttttaaa ctcttagagt ctacctttaa gagttatttt gataccaagt
    11581 tccctaaagt gatccttttc atgataaaat agaacaaatg tagaacaagg attaattatg
    11641 agtaagagag ctgtgttgat gatgaccttt gggtcaccag aagagattac ctatgaagga
//
