LOCUS       c00003_JAHDUS0..       14052 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHDUS010000011.1 Streptococcus thermophilus strain Racle124
            Contig_11, whole genome shotgun sequence.
ACCESSION   JAHDUS010000011
VERSION     JAHDUS010000011
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:42:39
            Original ID  :: JAHDUS010000011.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14052
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14052
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1265:4052](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1266..4052
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..14052
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14052
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             164..277
                     /locus_tag="ctg3_1"
                     /transl_table=11
                     /translation="MISLIYLKVNFVKFTCNKDKDTWSQNKNGTQIKLRKG"
     CDS             281..436
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_2"
                     /sec_met_domain="L_biotic_A (E-value: 3.7e-28, bitscore:
                     87.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 4.6e-08, bitscore:
                     23.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKETTIIESIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCCS"
     CDS_motif       281..355
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKETTIIESIQEVSLEELDQIIGA"
                     /locus_tag="ctg3_2"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       356..436
                     /prepeptide="core"
                     /locus_tag="ctg3_2"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2778.2"
                     /monoisotopic_mass="2776.3"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKETTIIESIQEVSLEELDQIIGA"
                     /leader_location="[280:355](+)"
                     /alternative_weights="2796.2"
                     /alternative_weights="2814.2"
     CDS             465..620
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_3"
                     /sec_met_domain="L_biotic_A (E-value: 3.7e-28, bitscore:
                     87.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 4.6e-08, bitscore:
                     23.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKETTIIESIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAF
                     LATCCS"
     CDS_motif       465..539
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKETTIIESIQEVSLEELDQIIGA"
                     /locus_tag="ctg3_3"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       540..620
                     /prepeptide="core"
                     /locus_tag="ctg3_3"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2778.2"
                     /monoisotopic_mass="2776.3"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKETTIIESIQEVSLEELDQIIGA"
                     /leader_location="[464:539](+)"
                     /alternative_weights="2796.2"
                     /alternative_weights="2814.2"
     CDS             1085..1246
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_4"
                     /sec_met_domain="L_biotic_A (E-value: 2.4e-26, bitscore:
                     81.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNNNKICQDALESLQELKLEEVDELLGGAGHGVNTISAECRWNS
                     LQAIFSCC"
     CDS_motif       1085..1171
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNNNKICQDALESLQELKLEEVDELLGG"
                     /locus_tag="ctg3_4"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       1172..1246
                     /prepeptide="core"
                     /locus_tag="ctg3_4"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="0.40"
                     /molecular_weight="2495.8"
                     /monoisotopic_mass="2494.2"
                     /core_sequence="AGHGVNTISAECRWNSLQAIFSCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNNNKICQDALESLQELKLEEVDELLGG"
                     /leader_location="[1084:1171](+)"
                     /alternative_weights="2513.8"
     CDS             1266..4052
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     689.6; E-value: 1.2e-208)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_5"
                     /sec_met_domain="LANC_like (E-value: 2.7e-54, bitscore:
                     174.1, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 1.6e-82, bitscore:
                     267.6, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQKEQLYSQFDKFPKVVIERLIPEVLNESDSLIKQIEEKISDYY
                     RSTLIYLINEKRINGTLVGETAELRYDFFNNVLCRNGTILDEIEERFPKINQRVFISIK
                     HYLDLLNCVKKHFVSDFLELKKLKFLKSNDESPDLNVLDIKVTGDIHNGSGVCILDYNR
                     QKLVYKKKSSRPNILLKELDSQASNYLKKEIRFIPDFLDKNEYFWEVFVESKPVSSLKE
                     ANEFYKRMGYLLVYSYILNISDLHFENLISHSIQPILVDAETVFSTNPYETVAENDATL
                     KIVENSRNSVLSTGLLPISEADKIFGGDTSGVLGGTLIGEAKVIINHNRDDIHVEKQKY
                     KTENQNHLPYFENNLGIKTYLNAEEYVEYIKEGFIELSKFIINNKEALKKLYLSFSDIK
                     TRVLFRNTRDYSLVRQLLLSPVYCNQDNILFEKMSNKLTNYDSHNLCQSEVKQLLNMDI
                     PYFYVCASDINVKDKDGNTNIWKLKKSSLSDTIEKLEKFDLDTMEEQLDLVEFSIKTPN
                     ALYSTELQESYKIFQNSNSNHSILFTGINTIVDTILKNEKFSKLDGSTNWLTLKVTDYD
                     AFQLEPMDSSIYEGIAGLSIALCEVYKLVDDDRQQRIYNCLRRIFMTLMKAYYSTQNQS
                     YYVGKLGILSAMIRIQSITGQEIPVSIFDINNKYILDLNVQSADFLSSFPSEIVALRNS
                     NVSIGNLQQSFEKLVDLKIISEDYIAWDKLESNNVSLAHGNLGIELGLLYLAVALNSSE
                     AVELFYQATNFDSHQKLSNGWIDKRNNSTSANWCHGSTGVLAARLAQLQLDKKFHIISK
                     TKRSELEADMKHAASQIIEIGFDMTNFSICHGTSGNLLALSYYCSYLSGNEREELEKIL
                     DIEYRKLHSFGLENGWMCSFNTKYNVYGIMNGLSGILYSTAKYLKKDDSLDILIPTL"
     CDS             4079..6151
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 128.8; E-value:
                     4.3e-39)"
                     /gene_kind="transport"
                     /locus_tag="ctg3_6"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.7e-39, bitscore:
                     123.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIILQNNEEDCLLACYTMLLNDLGHKVPLYEVYDKDSLPADGLN
                     VSYLLSLNKRFGVALKAYHASFRDLLQVYNEKKQRIILHWNQDHFVVLDKITEKQVTIV
                     DPAIGRVKYSHDEFLNHYSETIVLINKDENFQTQKYKQIFWKYFKLTLKTKTIILFLLS
                     LVLIQISVLAFSILLRYMLSEKFQFLSNILVLFGVVLFQLLGYFIKNSALNEYNLDFDD
                     NYSKALFQKLLKKPLLYFRNHLSGGISEKINFKSTLRDNVTLKIIPSCVSFISAIVIFT
                     YLITISVRLTIILIIIILVYSVISIILYRKQNEYNQTYLQYLIDFNSELQTDLDDIDYI
                     KIMRREGLTFASWMKINQQVTEKYSQILKFENLSQLVSTIFNYISLSVIIVIATYYNKY
                     IKVSISDLLVYQTSISLLISAIEQVKGAVFEVVKLGIYAEKQSDLLKDSRPILVQSSDS
                     DEYLIKAESLNFSYGMSPIYKDINLTINRGEKIAIIGKSGSGKSTLLLLLAGMLRFSGS
                     LKYGIKNFEDSLSVVLQNMTLRKGSVLENLEWDTDNLEPLYQVLKDTSADEVIAQLPNK
                     IHSKLLKQGKNLSGGQIQKMLIAKSLLKKNSIIFWDEAFSNLDEQSKNRIYLNILQNSQ
                     YSERTMLIVSHHLDIVDYVDYVIYIDNEMGDVYKDTHINLMESNENYRNFINSKI"
     CDS             6255..7166
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 173.8; E-value:
                     7.9e-53)"
                     /gene_kind="transport"
                     /locus_tag="ctg3_7"
                     /transl_table=11
                     /translation="MMNNIIELKKVKKVYKDITTVDIEKITVREGEIYGFLGPNGAGKT
                     TTMKMILSLVDPTSGEIFVNKKDIRKDKNYLSQIGSMIEEPSYYPNLTGYENLLVFQKM
                     VGFDENNIWPTLELVGLADEKNRKKLVKAYSLGMKQRLSLAFALVKKPKILLLDEPTNG
                     LDPAGIHEIRELIVELAKEKGLTVFISSHILPEIEHIADRVGIINHGRLVYEGEIEAIK
                     SNTWIEIGGDFSQSNIVHTLVELGTVEILGASTSHVKLSNIDNNQLANVVSYLTENGYR
                     IFRVVRESETLEDIFLSLTKEA"
     CDS             7168..7932
                     /locus_tag="ctg3_8"
                     /transl_table=11
                     /translation="MIKVLQIELLKSKRTKSFMISFLMMFVAVTWSLLAASRSIGVPKL
                     RTIGLFFNNLQATPIFLPIAISLFVSRIVSNEKEGNTFKLQEANNINLITIFKRKLIFT
                     NTIFLLLNVVQVLIVYLYAVRYGIDVAVSNLLLQVVGLTMSSFTLITFFLFLSMILEKH
                     GMVLGIGFVSGFLGMVLSEASKWLNLIFPFGGSSFLALYRIKVLHSGDKLDYIFVWDKS
                     VPLNYLIYLFYCIFVYFIIKYLLVKKKEENYD"
     CDS             7995..8732
                     /locus_tag="ctg3_9"
                     /transl_table=11
                     /translation="MIDYFKAEWIKNRKVVILAIGLIFLALSSFIGLANFFLNYDVLIE
                     EQMSRVLWGQLTFYNGQLLFPAMLAIFSGLIILPEFERKTLEMLRANQASVKKMVLSKF
                     LLALFLVSVVQAVLFAIYLLTLYLSQIPFQIEDLLLFLRATILSVIGSSSVLMIHSYLM
                     AKTRNFAKSVGVAAIGSFSGFIFIMLGGFINQLFPYSQPMIGLRSRALNDMSFLEFMLF
                     ITVNSLYSFIFYWLTVKKLENNE"
     CDS             complement(8693..8917)
                     /locus_tag="ctg3_10"
                     /transl_table=11
                     /translation="MIIARANLSFNFARKLLFYSLRKSGLLSFQEQIENQHSDYFMDLS
                     FILSTMLKNYTKNLSSRYSLFSNFLTVNQ"
     CDS             9012..9236
                     /locus_tag="ctg3_11"
                     /transl_table=11
                     /translation="MYQRIRDLREDHDFTQRFVANLLSFSHTNYAKIERGEVALTADVL
                     VQLSKLYNVSTDYLLGLTDYPDRIKHKIK"
     CDS             9277..9384
                     /gene="allorf_09277_09384"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_09277_09384"
                     /protein_id="allorf_09277_09384"
                     /tool="antismash"
                     /transl_table=1
                     /translation="VGLSYLSSNLVRYAVIGAKIISYKIEWFSICHNHK"
     CDS_motif       9277..9330
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: VGLSYLSSNLVRYAVIGA"
                     /locus_tag="allorf_09277_09384"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9331..9384
                     /prepeptide="core"
                     /locus_tag="allorf_09277_09384"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.70"
                     /molecular_weight="2110.5"
                     /monoisotopic_mass="2109.1"
                     /core_sequence="KIISYKIEWFSICHNHK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="VGLSYLSSNLVRYAVIGA"
                     /leader_location="[9276:9330](+)"
                     /alternative_weights="2128.5"
     CDS             9697..11451
                     /locus_tag="ctg3_12"
                     /transl_table=11
                     /translation="MKTNNVEIIKADSLVRRRGVNVERHLKRVAAYCRVSSDSEDQKNS
                     YESQVKHYKDYISQRSDWELADIYADEGISGTQVGKRQDFQRLINDCVNGEIDYIVTKA
                     IARFARNTLDTLKYVRMLKDMQIGVYFEEENIDTLTMDGELLLTILSSVAQQEVENTSA
                     HVKKGLKMKMQRGELIGFQGCLGYDYDVETKQLSINKKEAKIVRYIFERYLEGIGGKVI
                     ARELDELGYKSPRGLDHWNDTTVLGIIKNEKYKGDILMGKTFTVDPISKRRLSNFGEED
                     KYYIKDNHEPIISKEDFEKAQEIRLRRAGNKKTVANVNGKRERYSKMYAFSSMLECGFC
                     GSLLSRRSWHCRSDYRKVVWHCVTSIKKGKKYCKHSKGLEELAIEGAFMEAYRQLYHSN
                     ENIVSDLLETIESELNDNSLNKELKKITNKLRTLLKKEENLVNLKLEGKISDSIYNEKY
                     NELSLEKEYLAEEKVNVETTLKSEIDVKKRLTEFKQLLSSQKMLTEFDRTVFESIVEKI
                     IVGGVNSDGEIDPAMLTIIFKTGETQNKDGKQFKSKRKNAKLESDELCPQNCDEDKKLY
                     SQGIDNTC"
     CDS             complement(11735..11809)
                     /gene="allorf_11735_11809"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_11735_11809"
                     /protein_id="allorf_11735_11809"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKSKYSLLEAIIYTSKICIGLQDF"
     CDS_motif       complement(11768..11809)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKSKYSLLEAIIYT"
                     /locus_tag="allorf_11735_11809"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(11735..11767)
                     /prepeptide="core"
                     /locus_tag="allorf_11735_11809"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="1105.3"
                     /monoisotopic_mass="1104.6"
                     /core_sequence="SKICIGLQDF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKSKYSLLEAIIYT"
                     /leader_location="[11767:11809](-)"
     CDS             11839..12009
                     /locus_tag="ctg3_13"
                     /transl_table=11
                     /translation="VKPFKSAIAYMPNAKYESPYDGANEMLLVDDVDNKNYLTGLFNAM
                     YDELPAPKPKK"
     CDS             12241..12585
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111:GCN5-related N-acetyltransferase (Score: 63.3;
                     E-value: 4.5e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_14"
                     /transl_table=11
                     /translation="MQPVGSIGLMIGSASDKGIPDAEAEVGYWIGVLYWGQGLIPEAVR
                     EIMRHGFDDLNLEKMWFGYFDGNTKSKRVQEKCGFRYHHIKEKVPCALEGVFSTEHIAC
                     LSKAEWISIK"
     CDS             12765..13331
                     /locus_tag="ctg3_15"
                     /transl_table=11
                     /translation="MVILELYQGDYQKDLVAFDSLEEGRAFVAQIPGYTLETEDGFGVE
                     FVNPKYLPDYMEIVFNGNIVPLSRFSFNSEENVDIIWKEISNLSVKNDKVIEGYSKIDA
                     YVVNNDEVKAYVEAREANYRKAKDFLERCGYEADRSFFGSEDGEAILYRKKGTEDWKFL
                     CHLDPLFVEIEDVEGYVKEEIQLLN"
ORIGIN
        1 ctaggaagtt aagtagttct gtggtaaact gagtcatagg aataaatctc tttctagtaa
       61 tgttttgcaa ctctactata acggatttat tcctttttgt gtttacacaa cttattttac
      121 actaccagta aaatcaaaga tttaaaatct ttaaaataac tttatgattt ctttaatata
      181 tcttaaagtc aactttgtaa aatttacttg taacaaagat aaagacactt ggtctcaaaa
      241 taagaacggc actcaaataa aattaagaaa aggataaatt atggaaaaag aaacaacaat
      301 tattgaatca attcaagaag ttagtcttga agagcttgac caaattatcg gtgcaggaaa
      361 aaatggcgta tttaaaacca tctcacatga atgtcaccta aatacatggg catttcttgc
      421 tacatgttgc tcataagtta agaaatttta gaaagaggaa aactatggaa aaagaaacaa
      481 caattattga atcaattcaa gaagttagtc ttgaagagct tgaccaaatt atcggtgcag
      541 gaaaaaatgg cgtatttaaa accatttcgc acgaatgtca cctaaataca tgggcgtttc
      601 ttgccacatg ttgttcttga ttttggatga ctaagtgtct aatatgttac attaaaaaag
      661 gagggaaacc tcttttttat attcagaaat tttaattctt aaagataata gaattgctta
      721 tcgaaaaata gaatctagga gtaaagattt gtaaagtatt ttgtgtcaag acgagattct
      781 acccactaaa tattctccgt tgtattcact aaagtttacg atttaatgat gaaggataaa
      841 atgtgatgtg tatttaaaga aagtatatga tttacaactt atgtaaaaaa tattaagaag
      901 aggtataaat tagtaatgtg aagttacttt atccttgttt gattctgaac taacaagatt
      961 tatcaataaa ttaacattag ctttagatta gctttaactt ttctttatgt tgcgatttta
     1021 aaattaaagc ataaataaaa atattttcga gttatgctcg gtataacata tgaggtgata
     1081 aattatgaaa aataataata aaatttgtca agatgctttg gaatccttac aagaacttaa
     1141 gttagaagaa gttgatgaac ttttaggtgg agcaggccat ggagtaaata ctatttcagc
     1201 agaatgtcgt tggaatagtt tacaagcaat cttttcatgt tgctaatttt tagagaggta
     1261 atattatgaa tcagaaagag caactatata gtcagtttga taaatttcct aaagtagtaa
     1321 ttgaaaggct catccctgaa gttttaaatg aaagtgactc gctaattaag caaattgagg
     1381 aaaaaatttc agattattat agatctacat tgatttattt aattaatgaa aagcgcatta
     1441 atgggacatt ggttggtgaa acagcagaac ttcgatatga cttttttaat aatgtattat
     1501 gtagaaacgg tactatttta gatgaaatag aggaacgatt tcctaagatt aatcagcgtg
     1561 tatttatcag tattaaacac tatttagact tactaaattg cgtgaaaaag cactttgtga
     1621 gtgatttctt agaattaaaa aaattaaaat ttttaaagtc taatgatgag agtcctgatt
     1681 taaatgtttt agatataaaa gtcacaggag atattcacaa tggaagcgga gtctgtattc
     1741 tagattataa tagacaaaaa ttggtttata agaaaaaatc atcaagacca aatattcttt
     1801 taaaagaatt agatagtcaa gcaagtaatt atttgaaaaa ggaaattagg ttcattcctg
     1861 attttttaga taaaaatgaa tatttttggg aagtatttgt cgagagtaag ccagtatcct
     1921 cacttaaaga agcaaacgag ttttataaga gaatggggta tcttttagtt tactcctata
     1981 ttcttaatat ctctgattta cactttgaaa atcttatatc tcatagtatc caacctatat
     2041 tagtagatgc tgaaactgtt ttttcaacta atccatatga gacagtagct gaaaatgatg
     2101 caacattaaa aattgttgaa aatagtcgga attcagttct ttctacggga ttattaccta
     2161 tttctgaggc tgacaaaatt ttcggaggtg atacgagtgg tgttttagga ggaacgctta
     2221 ttggtgaagc aaaagttatt ataaatcata atagagatga tatacatgtt gaaaaacaga
     2281 agtacaagac tgaaaaccag aatcacttac catactttga gaataatttg ggaataaaaa
     2341 cgtatttaaa cgctgaagaa tatgtagaat atattaaaga aggcttcata gaattaagta
     2401 aatttattat taataataag gaagcattga agaaacttta cttaagtttt agtgatataa
     2461 aaacacgtgt tttatttaga aatactagag attatagtct agttagacaa ttattgcttt
     2521 caccagttta ctgcaaccag gataatattt tgtttgaaaa aatgtcaaat aaattaacga
     2581 actacgatag tcataattta tgtcaatctg aagtaaaaca acttttgaac atggatattc
     2641 cgtattttta cgtttgtgca agtgatatta atgttaaaga taaggacggt aatactaata
     2701 tttggaaact aaaaaaatct tcactgagtg atacaattga aaaattggaa aaatttgatt
     2761 tagatactat ggaagaacag ttagatttag tagaattttc aattaaaacc ccaaatgctt
     2821 tatacagtac agagttgcaa gagtcatata aaatttttca aaattcaaac tcaaatcata
     2881 gcatattatt tactggtatt aatactatag ttgatacaat tttaaaaaat gaaaaatttt
     2941 ctaaattaga tggaagtaca aattggttaa ctttgaaagt tacagactat gatgcatttc
     3001 aactagaacc catggattca tcaatttatg agggtattgc aggactgtct attgcgttat
     3061 gtgaagttta taaattggtc gatgatgata gacaacagag aatttataac tgtttacgca
     3121 gaattttcat gactttaatg aaggcttatt attctacaca aaatcaatcg tattatgttg
     3181 gcaagttagg aattttatct gcaatgatta gaatacagtc aattactggt caagaaatac
     3241 cagtatctat ttttgatatt aataacaaat atatcttaga tttgaatgtt cagagtgcag
     3301 attttctatc aagttttcct agtgagattg tagccttacg aaatagtaat gtatcaattg
     3361 gaaatcttca acaatctttt gagaaattag ttgatttgaa aattatttct gaagattata
     3421 ttgcgtggga taaattggaa tctaataatg ttagtttagc acatgggaat ttaggaatag
     3481 aactgggatt actttatctt gcggtggcat tgaatagttc tgaagcagtg gaattgttct
     3541 atcaagctac aaattttgat agtcatcaaa aattatcaaa tggatggata gataaaagaa
     3601 ataattcgac tagtgctaat tggtgtcatg gttctacagg ggtgttagct gcaagattag
     3661 ctcaattaca gctggataaa aaattccata ttatatctaa aacaaagaga agcgaattag
     3721 aggctgatat gaaacatgca gcatctcaga taattgaaat tggtttcgat atgacaaatt
     3781 tttctatttg tcatggaaca agtggaaatt tgttagcact tagttattat tgctcgtatc
     3841 tatcaggaaa tgaaagagaa gaattggaaa aaattttaga tatagagtat agaaaattac
     3901 attcatttgg tttagagaat ggatggatgt gcagctttaa tactaaatat aatgtttatg
     3961 gaataatgaa tggtttgtca ggaattttat attctacagc aaaatattta aaaaaagatg
     4021 attcgttgga tattttaatc cctactcttt aaaaagagat agaaaggaaa actcaagtat
     4081 gaagattatt ttacaaaaca acgaagagga ttgtctgtta gcgtgttaca caatgttatt
     4141 aaatgattta ggtcataaag ttccactata tgaagtatac gataaagact cattaccagc
     4201 agacggactt aatgtatcat acttgctatc tctaaacaaa agatttggag tagctttgaa
     4261 ggcgtatcac gcgtcgttta gagatttatt acaagtctac aatgaaaaaa agcaaagaat
     4321 aattcttcac tggaatcaag atcatttcgt agtattagat aaaattactg aaaaacaagt
     4381 tacgattgta gatcccgcta ttggtcgtgt aaaatacagt catgatgagt ttctaaacca
     4441 ctattctgaa actatagtgt taataaataa ggatgaaaat tttcaaactc aaaaatacaa
     4501 acagatattt tggaaatatt ttaaacttac tttgaaaaca aaaacaatta ttctattttt
     4561 gctttcgttg gtactaatcc agataagcgt tttagcattt tctatcttat taagatatat
     4621 gttatcagaa aagtttcaat tcttgtcaaa catactagtt ctatttggtg ttgttctttt
     4681 tcaactatta ggctatttta ttaagaatag tgccttaaat gaatataact tagattttga
     4741 tgataactat agtaaagcac ttttccaaaa attgttaaaa aaaccactat tatattttag
     4801 aaatcattta agtggcggta tttcagagaa gataaatttc aagtctactt taagggataa
     4861 tgtgacattg aagattatcc cctcttgtgt aagtttcatc tcagcaattg ttatttttac
     4921 atatttaata acaatttctg taaggttaac aataatcttg atcataataa ttttggttta
     4981 cagtgtaatt tctattatac tttatcgtaa acagaatgaa tataaccaaa cttatctgca
     5041 atatttgatt gactttaatt cagagttaca aacagattta gatgatattg attatatcaa
     5101 aataatgaga cgagaaggtc taacttttgc atcgtggatg aaaattaatc aacaagttac
     5161 tgaaaaatat tcacagattt taaagtttga aaacttatca cagttagtta gcacgatttt
     5221 taattacatt agtttgtctg taattatagt tatagcgact tactataata aatatattaa
     5281 agtatccatc tcggatttac tagtctatca aacaagtatt tcattattaa tatctgcaat
     5341 tgaacaagtg aagggtgcag tttttgaagt agtaaagttg gggatatatg ctgaaaaaca
     5401 aagtgattta ttaaaagata gtagaccaat tttagtacaa agttcagatt cggatgagta
     5461 tttaattaag gctgaaagcc taaatttttc ttatggcatg agtccgattt ataaggatat
     5521 taacttgaca attaatagag gtgaaaagat tgcaatcata ggtaaatcag gtagtggaaa
     5581 atcaacgtta ctattacttt tagcgggtat gctacgattt agtggatcgt tgaaatatgg
     5641 tattaaaaat tttgaagata gtttgagtgt tgttctacag aatatgacat taagaaaagg
     5701 aagcgtgtta gaaaatttag aatgggatac agataattta gagccattgt atcaagtatt
     5761 aaaagatact tcagctgatg aggttattgc ccagttacca aataaaattc attcaaagtt
     5821 attgaaacag gggaaaaatt tatctggagg acagattcaa aaaatgttaa ttgctaagtc
     5881 tttattgaaa aaaaactcta ttattttctg ggatgaagct ttcagtaatc ttgatgaaca
     5941 aagtaaaaat agaatctatc ttaatattct tcagaacagt caatactctg aaaggacaat
     6001 gttgattgtt agtcatcatc tagatattgt cgactatgtt gactatgtta tttacataga
     6061 taacgaaatg ggtgatgttt ataaggatac acatattaat cttatggaaa gtaacgaaaa
     6121 ctatagaaat tttattaatt caaaaatttg agacttgcgt tatacattct taatgttatc
     6181 tttaagatga acaggtacaa ttattaatgt aaagaaagga gtagtctaat aaaatagatt
     6241 gctaaaggat aatgatgatg aataatatta ttgagctgaa aaaagtaaaa aaagtttaca
     6301 aagatattac tactgtagat attgaaaaaa ttactgtacg ggagggagaa atttatggtt
     6361 ttctagggcc aaacggtgct gggaaaacga caacgatgaa aatgattcta tcccttgtag
     6421 atccgacttc aggtgagatt tttgttaata aaaaagacat tcgaaaagac aaaaattacc
     6481 tgagtcagat tggatctatg atagaagagc cttcatatta tcctaattta acaggttacg
     6541 aaaatttatt agtgtttcaa aaaatggtgg gatttgatga aaataatatc tggccaacat
     6601 tagaacttgt tggattagct gatgaaaaaa atcgaaaaaa attagttaag gcctattctc
     6661 taggtatgaa acaacgtctt tctttagcgt ttgcattagt aaaaaagcct aaaatcttat
     6721 tattagatga gcctactaat ggtcttgatc cagcaggtat tcatgaaatt cgtgaattga
     6781 ttgttgagtt agccaaagaa aaaggtctga cagtctttat ttctagtcat attcttccag
     6841 aaattgaaca cattgcagat cgagtgggta ttatcaatca tggtcgtcta gtttatgaag
     6901 gagaaattga agctattaaa tcaaatacct ggattgagat tggtggtgat ttttcacaga
     6961 gtaatattgt tcacacttta gttgaactag ggactgtaga aattttgggt gcatccacaa
     7021 gtcatgtaaa attaagtaat attgataata atcaattagc taatgtggtg agctatttga
     7081 cagaaaacgg ataccgtatt ttccgagtgg ttagagaaag tgagacccta gaagatattt
     7141 tcctttcgtt aacgaaggag gcttaaaatg ataaaggtat tacaaatcga attattgaag
     7201 agtaaacgaa caaaatcatt tatgatatcg tttttgatga tgtttgtagc agtaacttgg
     7261 tcattactag cagcatcaag aagcataggt gtaccaaagt taaggacaat tggattattt
     7321 ttcaataatt tacaagctac tcctattttt ttaccaattg cgattagtct ttttgtatcc
     7381 cgaattgtta gtaacgaaaa agaaggaaat acatttaaac tacaagaagc gaataatata
     7441 aatcttataa ccattttcaa acgaaagctt atttttacga atactatttt tctattattg
     7501 aatgtagtac aagtattgat tgtatattta tatgctgtta gatacggtat agatgttgct
     7561 gtttcaaatt tactattaca agttgtaggt ttgacgatgt ctagttttac tttaattact
     7621 ttttttctat ttctatctat gatattagaa aaacatggta tggttttagg aattggattt
     7681 gtatcagggt ttttagggat ggttctatcc gaagcatcta aatggttaaa tctaatcttt
     7741 cctttcgggg gttcaagttt tcttgcactt tatcgcataa aagttttaca ttctggagat
     7801 aaattagatt acatatttgt ttgggacaag agtgtaccac tcaactatct tatctatcta
     7861 ttttattgta tatttgtcta ttttattatt aagtacctat tggttaaaaa gaaggaggaa
     7921 aactatgatt gattatttta aagctgagtg gattaagaat cgtaaagtag tggttaaaaa
     7981 gaaggaggaa aactatgatt gattatttta aagctgagtg gattaagaat cgtaaagtag
     8041 ttattttagc tattggtctt atttttcttg ctttgtccag ttttattgga ttagctaatt
     8101 ttttcttgaa ctacgatgtg ttgattgaag aacagatgag tagggttctt tggggacagc
     8161 tgacttttta taacgggcag ttactttttc cagctatgtt agctatattc tcaggtctaa
     8221 ttatccttcc tgaatttgaa cgaaaaacac ttgaaatgct acgagctaat caagcatcag
     8281 ttaagaagat ggtactaagt aagtttttat tagctttgtt cttggtatct gtagttcaag
     8341 cagtgctgtt tgctatctat ttattaactc tttatcttag tcaaattcca tttcagatag
     8401 aggatttatt attatttttg agagctacaa tattatcagt tattggttca agttctgttt
     8461 tgatgattca cagttatctt atggcaaaaa ctaggaattt tgctaaatcg gttggagttg
     8521 cagcaattgg ttccttctca ggttttattt ttattatgct aggtggtttt attaatcaat
     8581 tatttccata ttctcagccg atgattggtt tacgaagtag ggcattgaat gatatgtcat
     8641 ttttagagtt tatgttattt attacagtga actccttgta tagtttcatt ttttattggt
     8701 taactgttaa gaaattggag aataatgaat aacgtgatga taaatttttt gtgtagttct
     8761 tcaacatagt agataaaatg aaactcagat ccataaaata atcgctatgc tgattttcga
     8821 tttgttcttg aaatgatagt aagcctgatt tacgtaaaga atagaacaac aactttcttg
     8881 caaaattaaa tgataaattt gcacgagcta ttatcataat tacaggaatg acgcaataat
     8941 tactgtcata ttatgacaat ttcccagctt ttttctgaaa gtgacatata cttttcttag
     9001 gagaaagcta tatgtaccaa cggataaggg atttgaggga agatcatgat ttcactcaaa
     9061 ggtttgttgc aaatttactt tccttctctc atacaaatta tgcaaaaatt gagagaggag
     9121 aggttgcctt aacggcagat gttctagtgc aactttctaa actctataac gttagtacag
     9181 attacctatt agggttaaca gattatccag ataggataaa acataaaata aaatagtctc
     9241 tccttgattt gttcattgac aattgaataa accgaggtgg gactttctta tttgtcgagc
     9301 aatttagtga gatacgccgt gataggagcg aaaattatta gctataaaat agagtggttc
     9361 tctatctgcc ataaccacaa ataaggacaa tgatacttct gaacgttcag gctgccatcg
     9421 taaaaggaca gcgggtgaaa tgcccatgaa tgatttaacc aatcatacct actgaggaaa
     9481 ttatagagta acacgttatc aggaggaaaa gttttggaac aatcagtagt aatatatagt
     9541 atgcaattat caatgcttaa ctttttatac tcaagaaata tgctatctaa aaatgagtat
     9601 gaaaaaatca gaaacaaact gcgtattaag tacacaaaat agctgacctt tttatttgaa
     9661 cgcggtaata tagaatcaaa aggaggaatt tcagttatga aaacaaataa tgttgaaata
     9721 ataaaagctg attctttagt tcgacgtaga ggtgtcaatg ttgaaagaca tttaaaaagg
     9781 gttgctgctt attgccgagt gagttctgat agtgaggatc agaagaacag ttatgaatct
     9841 caggtgaaac attataaaga ttacatttct cagcgttcag attgggaact cgctgatatc
     9901 tatgcagatg aggggatttc aggaactcaa gtaggaaaga gacaagattt tcaacgctta
     9961 atcaatgatt gtgtaaatgg agaaattgat tatattgtaa caaaagcaat tgctagattt
    10021 gcaagaaaca ccttagatac tttgaagtat gtcagaatgt taaaggatat gcaaattgga
    10081 gtatattttg aggaagagaa cattgatacc cttactatgg atggagaatt acttctaacc
    10141 attcttagct ctgttgcaca gcaagaagta gaaaatacat ctgcacatgt gaaaaaggga
    10201 ttaaaaatga agatgcaacg tggtgaactg atagggtttc aagggtgctt ggggtatgac
    10261 tatgatgtag aaaccaagca actttcaatc aataaaaaag aagccaaaat agttcgttat
    10321 atctttgaaa ggtacttaga aggtattgga gggaaagtca tagcaaggga acttgatgaa
    10381 ctaggttaca aatcgccgag aggattagat cattggaatg atacaacagt cttaggaatc
    10441 ataaagaatg aaaaatataa aggcgatatt ctaatgggca aaacttttac agtggatcca
    10501 ataagcaaga gacgtttaag taattttggt gaagaagata agtactacat caaagataat
    10561 catgaaccta taatatctaa agaagacttt gagaaagctc aggagattag gttgcgtagg
    10621 gcaggaaata aaaagacagt tgcgaatgta aatggaaaac gtgaacgcta ttcaaaaatg
    10681 tatgctttta gtagtatgtt agaatgtggt ttttgtggtt cattattgtc taggagaagt
    10741 tggcactgtc gttcagatta tcgaaaagtt gtgtggcatt gtgttacttc gataaaaaaa
    10801 gggaaaaaat actgtaaaca tagtaaagga ttagaggaac tggctattga gggagctttc
    10861 atggaagcat atagacaact ctatcattca aatgaaaata tagtgtcaga tttacttgaa
    10921 acgattgaat ctgaattaaa tgacaatagc ctcaacaagg aactgaaaaa aataactaat
    10981 aagcttcgta ctttactaaa aaaagaggag aatcttgtaa atttaaaact agaaggaaaa
    11041 ataagtgatt caatttataa tgaaaaatat aatgagctct ccttagaaaa agaatatctt
    11101 gcagaagaaa aagtaaatgt tgaaacaaca ttgaagtcag aaattgatgt taagaaaaga
    11161 ctaactgagt ttaaacaatt actgtcttca cagaaaatgc tcactgagtt tgatcgtaca
    11221 gtttttgaga gcatcgttga gaaaattatt gtaggtggtg ttaatagcga tggtgaaatt
    11281 gatcctgcaa tgttaactat tattttcaaa acaggagaaa cacaaaataa ggatggcaaa
    11341 caattcaaaa gtaaacgtaa aaatgctaaa ctagaatcag atgaattgtg tcctcaaaac
    11401 tgtgacgagg acaaaaaatt gtattctcaa ggaatagaca acacatgttg aggcggtatc
    11461 actacttgta cgagctgaga cttcagcgaa gtagaagtag atgctccgcc catgcgatag
    11521 ctgtcgtaga gtaaggagtt tacgacgaaa cgatacggta atagcgaacc gccgagtgtg
    11581 tgagttttta gtgaaacgta gctaatcctc aaaaggttct ccgaaccttt tgagtcccac
    11641 ggacgcatca tgttgaatgc gtaacactgc ttgtacgagc tacgaagtag catagtagaa
    11701 acggaaggcc caccatattg aactaatata agtattaaaa atcctgtaga ccaatgcaaa
    11761 ttttggaggt gtagattatg gcttcaagca aagaatattt agatttcatt attgtgaatt
    11821 tatgatgata gatttttagt gaagcctttt aaatctgcaa tagcatatat gccaaatgca
    11881 aagtacgagt caccatatga tggagcaaat gaaatgctgt tggtagatga tgttgacaac
    11941 aaaaattatt taactggctt attcaatgca atgtatgatg aattacctgc acctaaacca
    12001 aagaaatgat cagagtggaa tttaaggaga aaaaacgatt ttagaaacgg aaaggttgat
    12061 tcttcgccca tgggaagaaa gagatgccaa tgatttattc caatatgcca gtaatccaga
    12121 ggttcagaga ttggtccgat tgcaggttgg ccagtacata ctagtgttga aaacagtagg
    12181 gaaattataa aaagttattt ttccgcacct gagacatacg ctatagtttt aaaagaaaca
    12241 atgcagccag tgggtagcat aggtttgatg attggctctg caagtgataa aggtattcct
    12301 gatgctgagg cggaggttgg ttactggata ggagttctgt attggggtca ggggcttata
    12361 ccagaagcag ttcgtgagat aatgagacat ggatttgatg acttgaattt ggagaaaatg
    12421 tggttcggtt attttgacgg caatacaaag tcaaagagag ttcaggaaaa atgtgggttc
    12481 cgttatcatc atataaaaga gaaggttcca tgtgcattgg aaggtgtttt tagcacagaa
    12541 cacatcgcct gtctctcaaa ggcagagtgg atttcaatta agtaaatctt agtttgttga
    12601 ggtcatacct ttaaatgata accttatgcg atcgttaaaa gctctataga cctgtttcta
    12661 catacagata ggttcactcg tttcatgttg atgtagtatc actgcttgta agatttgaaa
    12721 aataaatttg cgtagcgtcg taaaggttaa atggagggtt atcgatggtt atattggaat
    12781 tgtatcaagg tgattatcaa aaggatttag tcgcgtttga ttctttagaa gaggggagag
    12841 cgtttgtagc tcaaatcccg gggtatactt tagaaacaga agatgggttt ggggtggagt
    12901 ttgtgaaccc aaaatacttg ccggattata tggaaattgt ctttaacgga aatattgtcc
    12961 ctctatctag attttcgttt aattctgaag aaaatgtgga tattatttgg aaagaaattt
    13021 cgaatctatc cgttaaaaac gataaagtga ttgaaggata ttcaaaaatc gacgcgtatg
    13081 tcgttaacaa cgatgaagtg aaagcctatg tcgaagcaag agaagcgaac tatcgcaagg
    13141 caaaagactt tctagaacgc tgtggatatg aggccgacag aagctttttc ggaagtgaag
    13201 acggcgaagc gattctctat agaaaaaaag gtaccgaaga ttggaaattc ttatgccact
    13261 tagacccact atttgtagag attgaagatg tagaaggata tgtcaaagaa gagattcagt
    13321 tgttaaacta aagaatgttg cgaaggcgtg gcgtgagtta tatttaaaaa ggcttctatt
    13381 ttgccagatg gtggaattaa ggagaaattt atgaccttaa aacaaattaa atttaattct
    13441 tttaaacact ggggaatcat cagcgacttg tataagcagt cctttccaaa ggaggagcga
    13501 attcccttct ttggacttgg ctcttatcat tgagaaaaat ggatttacac tgtgtccctg
    13561 tctcattcgt gaattaggcg ttgactttgc tcttatgagc cagacagggc aactaattcc
    13621 attcgactat caggatatct ttgacaattt ctcttttgga cttggagatg tatcaatttg
    13681 ttcgataaat taataaaacg taccttacca aaattgtact gaactaaaaa attatctaat
    13741 tgagaaaaga acaaaagttt tggtctataa tatagatatt ttctagcatc acatgtggag
    13801 gcagtctcac tgcttttacg agctgagacc tcagcgaagt agaagcagat gttccgccca
    13861 tgcgacaagg tgagaccgaa ggtcgagaag gtgccctggg gtataggact cgtagaatga
    13921 ggaggtacac cgacgagatg atacggtaag tccgaaccgc ttagtgtgag tttattggta
    13981 aaacgcagct aaacgtctcg aatatttcat tcacggtgag atgctgtagc taagaatgag
    14041 ctaattgagg at
//
