LOCUS       c00040_JAHRBG0..       12804 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHRBG010000045.1 Streptococcus thermophilus strain Roque89
            Contig_45, whole genome shotgun sequence.
ACCESSION   JAHRBG010000045
VERSION     JAHRBG010000045
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:51:41
            Original ID  :: JAHRBG010000045.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 43713
            Orig. end    :: 56517
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12804
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[53713:56138]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12425
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..12804
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12804
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             complement(448..1542)
                     /NRPS_PKS="Domain: Aminotran_5 (2-349). E-value: 2.9e-44.
                     Score: 143.2. Matches aSDomain:
                     nrpspksdomains_ctg40_49_Aminotran_5.1"
                     /NRPS_PKS="type: other"
                     /locus_tag="ctg40_49"
                     /transl_table=11
                     /translation="MTIYNFSAGPATLPKPVLEKAQAELLNYQDSGMSVLEMSHRSPEF
                     DKIIKDAEATLRELMAIPDNYKVIFLQGGASTQFTMVPLNLAQGKKAYYLVGGSWGKKA
                     YTEAVKLSKTIPFEPILLASSEDTVYDHIPSFDPSTIDPEAAYVHLTTNNTIEGTSIYD
                     LPDTNGVPIVADMSSNILAARYNVEDFALIYAGAQKNIGPAGVTVVIVREDFLNDQPQL
                     SAMLDYRIQAEAGSLYNTPPCFNIYISKLVFDWVKNEIGGVDKMAEIQREKSGLLYDYI
                     ESSDFYTNPVKDAKDRSVCNIPFVTPSKDLDAKFVAEADALGFKNIKGHRSVGGMRASV
                     YNAFPRQGVLDLIDFMKKFEDENK"
     aSDomain        complement(496..1536)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg40_49_Aminotran_5.1"
                     /evalue="2.90E-44"
                     /label="ctg40_49_Aminotran_5.1"
                     /locus_tag="ctg40_49"
                     /protein_end="349"
                     /protein_start="2"
                     /score="143.2"
                     /tool="antismash"
                     /translation="IYNFSAGPATLPKPVLEKAQAELLNYQDSGMSVLEMSHRSPEFDK
                     IIKDAEATLRELMAIPDNYKVIFLQGGASTQFTMVPLNLAQGKKAYYLVGGSWGKKAYT
                     EAVKLSKTIPFEPILLASSEDTVYDHIPSFDPSTIDPEAAYVHLTTNNTIEGTSIYDLP
                     DTNGVPIVADMSSNILAARYNVEDFALIYAGAQKNIGPAGVTVVIVREDFLNDQPQLSA
                     MLDYRIQAEAGSLYNTPPCFNIYISKLVFDWVKNEIGGVDKMAEIQREKSGLLYDYIES
                     SDFYTNPVKDAKDRSVCNIPFVTPSKDLDAKFVAEADALGFKNIKGHRSVGGMRASVYN
                     AFPRQGV"
     CDS             complement(1698..2483)
                     /gene_functions="other (smcogs) SMCOG1108:ROK family
                     protein (Score: 108; E-value: 1e-32)"
                     /gene_kind="other"
                     /locus_tag="ctg40_50"
                     /transl_table=11
                     /translation="LDKALDVIDHLVTSVEVALSGSAISVPETVDTEGGCDLSRRFVEI
                     LSCFRVKETLQAKYHFPVAALNDGKAAALAELATGHLKGVTNGAALVLGSGLGGGIIIN
                     GKLFQGSHFQAGELTFLLPLQMEKLDPSLMQGTTLSAIGLITKVNEILASLDLKDGLLA
                     FKAINAKKEAVYPIFETYCRNLAITILNLQTIFDMGTFVLGGGISAQSILIEEVNRQFD
                     KVHHEIDFIGKIIKRPKIVACHHHNGTNLIGAAYFLKQG"
     CDS             2495..2656
                     /locus_tag="ctg40_51"
                     /transl_table=11
                     /translation="MIALANSFRGQGPLKQEQTLPESLQNQLLKLEKTLSKCYNGFRKL
                     DKRSLSHD"
     CDS             2649..3044
                     /locus_tag="ctg40_52"
                     /transl_table=11
                     /translation="MTKFLHTCVRVKDLEASLKFYKEALGFKEARRNDFPEYKFTLVYL
                     QLEDDPDYELELTYNYDHEAYDLGDGYGHIAVGVDDLEATHQAHKEAGYTVTDLSGLPG
                     KPKMYYFITDPDGYKIEVIRLAQFLEK"
     CDS             complement(3086..3532)
                     /locus_tag="ctg40_53"
                     /transl_table=11
                     /translation="MTAYGYIIVKTLITKVEPDAEVKQSTNEINAAQRKRVAAQELAEA
                     DKIKIVTAAEAEAEKDRLHGVGIAQQRKAIVDGLAESIAELKEANVGMSEEQIMSILLT
                     NQYLDTLNTFAAKGNQTLFLPNNPNGVDDIRTQILSALKADNKN"
     CDS             complement(3948..4388)
                     /locus_tag="ctg40_54"
                     /transl_table=11
                     /translation="MTPQEMWNAYKKINPSIGDEIDAWAFGVEADLLADLVLKGEKTAT
                     ASAYDLYALADEALPQEGTFDIILDSQDQAVCIVEITKVSVQPFHQVSADHAFKEGEGD
                     KSLAYWRQVHEDCFAEWLREAGMTFTPNSKVVLEEFRKVYPL"
     CDS             complement(4400..4564)
                     /locus_tag="ctg40_55"
                     /transl_table=11
                     /translation="MNLQAFVNDNYDVLDISTGQTEIIQDFISIQEISETLNYYMENML
                     KLNCKGKFS"
     CDS             5053..5418
                     /locus_tag="ctg40_56"
                     /transl_table=11
                     /translation="MKKPKFEFYTRLNGHTEFLEFLQTIPIKDKQKLLATIATIQEHGL
                     LVAQRMEWVKKLDDDIFEIRSKVASNIQRALYFHVINERYIITHGFTKKTQKTPQSEIK
                     HAKDLKKEFEDNNHDHN"
     CDS             5405..5680
                     /locus_tag="ctg40_57"
                     /transl_table=11
                     /translation="MTTIKFDDFLENELADKNFKEGFLTEKAILESAIAVSDARQTAGL
                     TQRELASLSHVPQSTIARIERGHNTSIETMSKIALALNKNLTIKIS"
     CDS             complement(5750..6052)
                     /locus_tag="ctg40_58"
                     /transl_table=11
                     /translation="MSQKYTKEFKETIVQLHETGYPVSDLVKEYGVANQTIYKWLQLYG
                     KSGKSKAENVSLHELQQMRKEMAQFLIKLYQSDEVVGLVDVKNFEFHLSGPLFNH"
     CDS             complement(6382..6516)
                     /locus_tag="ctg40_59"
                     /transl_table=11
                     /translation="MLNKIKARLLIGLGGLAVTSFIVMIGYTIGSQSVTSHTHKQIQS"
     CDS             complement(6639..7901)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 105.9; E-value: 3.6e-32)"
                     /gene_kind="transport"
                     /locus_tag="ctg40_60"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVIF
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNSYGVSLLLACPIVLSSNVLAHFLSDEITSNIIPLTLYT
                     FIIMGIFPIYESSKMLLQGTENEKFVLQVSIWINLICVAIMILFQFLRVQTYFSLYFIY
                     GLSLTVLSIIFLQHASSEKII"
     CDS             complement(8131..8220)
                     /locus_tag="ctg40_61"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(8217..8828)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_62"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.9e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNDMLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERIS
                     KGEFKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGV
                     RACSINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCS
                     ECPLPWCGGGCRCSALELDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(8913..10004)
                     /locus_tag="ctg40_63"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(10001..11320)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_64"
                     /sec_met_domain="PF04055 (E-value: 5.3e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.2e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.5e-13, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 1.1e-24, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(11390..11482)
                     /locus_tag="ctg40_65"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(11565..12425)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_66"
                     /sec_met_domain="TIGR01716 (E-value: 5.4e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(12718..12804)
                     /locus_tag="ctg40_67"
                     /transl_table=11
                     /translation="YIETYYNTKRMHSGLDYKSPKDFEKYNS"
ORIGIN
        1 agccaagttt ctccaaaatg tgctgcatga caagattctt ttcatgcgtg tcgcaacgaa
       61 aatcatgagc gtcagttccc tcaataagac cttgaataaa ggtttgagca tttttctgtc
      121 ccgtaaattc tcttaaaacg gcaattcgat gaaaggtaac atagcgatta ttatgatgct
      181 tccaatctcc atcatagatt ttttcgtagg cgggctctcc atcagtaacc accgcagcat
      241 aagaaacaat ttgaccgtca atgataccga cataggcctg tcctttaaga acatcatcaa
      301 agatgatttc ttctgtaaga taaccatcag ccccttgcca ttgagaacta ccagcttccg
      361 ctaaagcaat tctagcactc tcaatcacgg tcatgatagc accaatttca tttgggaaag
      421 cttgtctaat ttccatctct ttcctaatta tttattttca tcttcaaatt tcttcataaa
      481 gtcaatcaaa tcaagcacac cttgacgcgg gaaggcgtta taaacactgg cacgcatacc
      541 acccactgaa cggtgtccct tgatattttt gaaaccaaga gcatctgctt ctgctacaaa
      601 tttggcatcc aagtctttac ttggtgtgac aaatggaatg ttgcagacag aacgatcctt
      661 ggcatcttta acaggattgg tgtagaaatc agatgattcg atatagtcat aaagaagacc
      721 tgatttttca cgttgaattt ccgccatctt atctacgcca ccaatctcat tttttaccca
      781 gtcaaaaacg agttttgaaa tatagatatt gaaacatggt ggtgtattgt agagtgatcc
      841 tgcttcagct tgaatacggt agtccaacat ggcagacaat tgtggttggt cgttaaggaa
      901 gtcttcacgg acgataacca ccgtcacacc cgcaggtcca atatttttct gagcaccagc
      961 atagataaga gcaaaatcct caacattata gcgagctgct aagatattcg aagacatatc
     1021 tgctacaatt ggcacaccat tagtatcagg caaatcatag atagatgttc cctcaattgt
     1081 attattggta gtcaagtgaa cataagcggc ttctggatca atcgttgaag gatcaaaact
     1141 tgggatatga tcgtaaacag tatcctcaga tgacgccaaa agaattggtt caaaaggaat
     1201 agtttttgaa agcttgacag cttcagtata ggctttttta ccccatgaac cacctacaag
     1261 gtagtaagct ttcttacctt gagcaaggtt cagtggaacc attgtgaatt gcgttgaagc
     1321 ccccccttgc aagaaaataa ccttatagtt atcaggaatg gccataagct cgcgaagtgt
     1381 cgcttccgca tctttaatga ttttgtcaaa ttctggagaa cggtgggaca tttctagcac
     1441 ggacataccg gaatcttgat agttaagcaa ttcagcttgt gctttttcga gcacaggttt
     1501 tggtaatgta gcaggtcctg ctgagaaatt ataaattgtc ataaagacac ctccaaaatt
     1561 ttaatgggcc cattatagcg aattttctga atattgtaaa gtgttaatag taaaaaacga
     1621 acggaattgc ccgttcgtca caaaaaaaag ttaggtattt tatgtatatt tttgcaagta
     1681 atcagattta ctatccgtta tccttgctta agaaaatagg ctgcaccgat tagatttgtt
     1741 ccattatgat gatgacaggc tacaatcttt ggacgtttaa taattttacc gataaaatca
     1801 atctcatggt gaaccttatc aaactggcgg ttgacttctt ctatcagaat agactgagct
     1861 gaaataccac ctccaagaac aaaggttccc atatcaaaga tagtttgaag attcaatata
     1921 gtaatagcta ggtttcgaca ataggtctca aagattggat aaactgcttc ctttttagca
     1981 ttaattgcct taaaggctag caaaccatct tttaaatcaa gactagctaa aatttcatta
     2041 actttagtaa tcaaaccaat agctgaaaga gttgttcctt gcatcaatga aggatcaagt
     2101 ttttccattt gaagaggaag gaggaaggtc aactctcctg cctggaaatg gcttccctga
     2161 aaaagtttac cattgattat tatacctcca ccaaggcctg accctaaaac aagagcagca
     2221 ccgttagtca ctcctttcag atgacctgtg gctagttcag ccaaggctgc tgctttacca
     2281 tcattaagcg cagctactgg aaaatgatac ttagcttgca gggtttcttt gacacgaaaa
     2341 catgaaagaa tctcaacaaa ccgccgtgat aaatcacacc ctccttccgt atcaacagtt
     2401 tcaggaacac taattgcact gcctgataaa gctacttcaa ccgaagttac taaatgatca
     2461 ataacatcga gagccttatc caaggtctga ggggatgatt gcgttggcaa actcttttcg
     2521 aggacaaggt cctctgaaac aagagcagac tttacctgag tccctccaaa atcaattgct
     2581 aaaactagaa aaaacgctat caaaatgcta taatggtttt agaaaactag ataaaaggag
     2641 tctctcacat gactaaattt ctacacactt gtgtccgtgt caaggaccta gaagcctcac
     2701 ttaaatttta taaagaagct cttggtttca aagaagctcg tcgaaatgat tttccagaat
     2761 ataagttcac ccttgtctac ttgcaactcg aagatgatcc tgattacgag ttggaattaa
     2821 cctacaatta tgaccacgaa gcctatgatt taggagatgg atacggtcat atcgctgttg
     2881 gtgtcgatga tttagaagct acacaccaag ctcacaaaga ggctggatac actgttacag
     2941 acctctcagg tcttcctggt aaaccaaaaa tgtattactt tatcactgat ccagatggct
     3001 ataagattga agttattcgt ttggctcaat tcctagaaaa ataaatcaaa aaagtcagat
     3061 cgtatagatc tggctttttt tgtgcttaat ttttattatc tgctttcaag gctgacaaaa
     3121 tttgggtacg aatatcatcc acaccgtttg gattatttgg caagaataag gtttgatttc
     3181 ctttcgccgc aaaagtatta agggtatcca aatattggtt agtcaagaga atagacataa
     3241 tctgctcttc agacatcccc acattagcct cttttagttc tgcaatagat tcagccaatc
     3301 catcaacgat agccttacgt tgttgggcaa taccaacacc atgaagacga tctttttcag
     3361 cttcggcttc ggctgctgtg acaatcttaa tcttatcagc ttctgccaat tcttgggctg
     3421 ccacacgctt acgttgggca gcattaattt cgttcgtaga ctgcttaact tcagcatctg
     3481 gctcaacctt ggtaatcaag gtcttaacaa tgatgtatcc ataagctgtc atttcttagg
     3541 ctacttgatg ttgaacctca agagcgattt catctttctt ctcaaaaagc tcatcaagcg
     3601 tcaatttagg aactgatgaa cgaagggcat caatgtatga tttaatttga gcctctggtc
     3661 gcatgagttt gttgtctctt gtgccgatga cagctcttct ttcgaaatct taagtagccc
     3721 cttttttatg atatcatatc tcaaaagagc ctattcaaaa gccaaatctc tgtcactttt
     3781 agaattaaaa cgcatctcga atatcccctt taaaaagaga ctgggacaaa agtcctagcc
     3841 tctcaattgt ctttggattg ccgagcaaga cgcaatggtt gagtgggctc tactacgctg
     3901 atttcatcag cttttacagt cctactcaac tgtcccactc tcatgttcta taatggataa
     3961 accttgcgaa attcttctaa aacaaccttg ctattaggtg taaaagtcat tcctgcctct
     4021 ctcagccact cagcgaaaca gtcctcatga acctgacgcc aataggctag ggatttgtca
     4081 ccttcccctt ccttgaaggc atggtcagct gacacttgat gaaaaggctg aacagaaacc
     4141 tttgttattt cgacaatgca gacagcctga tcttggctat ctaaaatgat atcaaaggtc
     4201 ccttcttgtg gaagggcttc atccgctaga gcgtaaagat cgtaagctga agcagttgcc
     4261 gtcttttcac cttttaaaac caagtctgcc aagagatcag cttccactcc aaaagcccag
     4321 gcatctatct catctccgat agaggggtta attttcttgt atgcattcca catttcttgc
     4381 ggtgtcatga gtgctccttt cagctaaatt tgcctttaca atttaacttt aacatatttt
     4441 ccatgtaata atttagtgtc tctgaaatct cttgtataga aatgaaatcc tgtataattt
     4501 cagtttgacc tgtactgata tctaaaacat catagttgtc attaacaaaa gcttgtaaat
     4561 tcatcttatc aatgtttcaa aatcaggttt taacaactgc tttctagcaa aacgagaaaa
     4621 gtttgaaaaa acatcttgct tcatttgctc taacagtttt tgattttcga tactgtcaat
     4681 aattttcaag ttatacataa aattactgtg cagtgaattc aattactatt ataccaaatc
     4741 caattctact ttagttataa tttccattta tttagtgaca tactacaaca ctatccgaat
     4801 atagaaatta atctaaaatt acaagaaata cccaaagtgt tcctttggca tacatatatg
     4861 tcacttagag tttatctcaa ccgtcaacag atggaataaa tttactacta ttttcgcaac
     4921 tattttcaca accaaaacta agattaagaa taaaaaatac ataattacta tatgattgca
     4981 acatagcatt tggataaagt tcacaccatt attcttgaag aaaagaacaa tatatgctat
     5041 catggagata caatgaaaaa gccaaaattt gagttttata ctcggttaaa tggacacacc
     5101 gagttcctag aatttttaca aactatacca attaaagaca aacaaaaatt actggcaact
     5161 atcgccacta tacaagagca tggtctttta gttgctcaac gtatggaatg ggtgaaaaag
     5221 ctagatgacg acatctttga aatccgctca aaggttgctt ctaacattca aagggcactt
     5281 tattttcatg ttatcaatga acgctacatc atcacccatg gctttaccaa aaaaacacaa
     5341 aaaacacccc agagtgagat aaaacacgct aaggatttaa agaaagaatt tgaggacaac
     5401 aaccatgacc acaattaaat ttgatgattt tttagaaaac gaactagcag acaaaaattt
     5461 taaagaaggc tttttaactg aaaaagctat tttggaaagt gctattgcag tttctgacgc
     5521 acgacaaaca gcaggtctca cccaaaggga gctagcttcc ctatctcatg tcccacagtc
     5581 taccattgct cgcattgaac gtggacataa cacaagcatt gaaacaatga gcaaaattgc
     5641 acttgctctg aataaaaatc taactatcaa aataagctaa tagtcaaatt aagctctcaa
     5701 aaaagctgat gaaatataaa ttcatcagct tttttatcac atgtaacaat caatggttaa
     5761 acaatggccc actaaggtgg aactcaaagt ttttaacatc aactaaacca acaacttcgt
     5821 cactttgata taattttatc aaaaattgtg ccatctcttt gcgcatttgt tggagttcat
     5881 gaagggatac attttcagct ttagatttgc cagacttccc gtatagttga agccatttgt
     5941 atatagtttg gttggcaact ccgtactctt tgactagatc tgaaacagga tagcctgttt
     6001 catgtaattg aacaatagtt tccttgaact ctttggtata tttttggctc atttggacat
     6061 ctcctttagg tagatactat tctaccaaaa cgtgtccata aaatcatact aacatcagct
     6121 tgaaagtttt cgtctctgtc tgagtacttt tctgcgcctt ttcactcaca tcagacacat
     6181 aaacaacttg ataagaaact tctgcgagag cttcattatt ctccgtatta acatagatac
     6241 gagctgtatc aaagcgataa tctaaaatat agtccttgct tttccttggt gtaatactga
     6301 gtgagaaact tttttaacca gatcatcaga taagacgtct gccttttcct tttgtttctc
     6361 ttttgtcagt agtttgtgag cctatgactg gatttgctta tgcgtatgac tggtcacaga
     6421 ctgagaacca atggtatagc caatcattac gataaaactg gttacagcta gtccacccaa
     6481 gccaattaaa agcctagctt ttattttatt taacatgatt gttgctatct cctttatatt
     6541 aagatagccc catcataaca agattaactt ggaaaagtta tcacaagaaa aaaagattta
     6601 gcctgtaatt ttaagactaa atcttattat attatcattt atataatttt ttctgaagaa
     6661 gcatgttgta aaaatattat agataaaacg gtcagactta aaccatagat aaagtacaat
     6721 gaaaaatatg tctgtactct taaaaattga aataaaatca ttattgcaac acaaataaga
     6781 tttatccaaa tcgatacctg caaaacaaat ttctcatttt ctgtgccttg taataacatt
     6841 ttagaacttt cataaattgg aaatattccc ataataataa atgtgtacaa agttaaagga
     6901 ataatatttg aggttatttc atctgaaaga aaatgagcta agacatttga tgataaaaca
     6961 ataggacaag ctaataacag actaacacca tatgaatttt taaatatgtt ttttaaaaat
     7021 acgttaacct ctcctatttt ctctgcttca ggtaaataga tagaaacggt tgtcgaataa
     7081 acaaaagaag gtacactcac aattgaaagc aattgactaa taactgcata aatagccaac
     7141 aattctactc ctaatctcga catcaaggca tcaaacacca taataaacaa aacactctcc
     7201 agaatttctt gaccaaccaa aggaatacca aatgttatta attcaaattt agttgtagat
     7261 gtaatggata aagccttcaa aatcattgga taaaccataa acaagtaact aagcgatatg
     7321 aaagctaagg atacaatcgt tgatatggct gctcccttaa ttccgatttg tggtaccagt
     7381 acataattta acacaacatc tattaatgaa ctgataagtc caacccacat aattggtttt
     7441 gttttctttt gaactcttaa taaatttgtc agcgaaaagt ttaataatgt caatccgata
     7501 tatggagaca tgaagactaa ataaatggtg gataaggaca atagttgccc tttaaatcca
     7561 tagagctgct tcaagattac atttccaaaa aaaatgacaa aaaccgcaaa ggcaactccg
     7621 ataattaaat ctaaggttag atttgatttc aataaatcat caaacctgtt agtttgccga
     7681 ttagagtacg ccttagagct tttaatatta aatgacaaac tgaatgctcc taaaagtcca
     7741 ccaaaagcaa ataagagatt ctgaataatg gaaattcctg acagagcaat tgaggaattg
     7801 ttcacagcaa aatgcaatgc tatctgccca ataattactt gaccaatatt tgttaaaact
     7861 aagggaaagg caaatttgtt aatttctttt gaatctatca tttttcctct ctaaaaggct
     7921 tcaaatgtaa gtaaagatca gatttaacta aatttgcata aataatatgc aaaataggag
     7981 tttcttctaa aaatgaaata attgcctgct tacaatcatt agcagatacc tcataatctt
     8041 gctgtaatag ttctacaatc ttgtctaaag aaaaattttt agaaatgcaa taaagtattt
     8101 ctgctcctat ttcatcaaat gaatagtact ctaatcaagt agatcgtatc ctatgtattc
     8161 atctgctact ttatttacaa tgaaatctct cttacctctt atcacaaaat gttctttcat
     8221 acgactactc cacctccttt ttgttcataa aagcaggcta aatcagagcc cagtaacgtt
     8281 ccatctaatt ccaaggcact gcatcgacat cccccaccac accatggtag gggacattct
     8341 gaacatttcc cagaaatatc atcaaatgta attgatctta gtttattaaa tacagcagaa
     8401 tggtgccaaa tttcgctaaa cttttgttct ttaacatttc cagcaactaa ttcatctata
     8461 ccattcatca agtcacaccc gtatacatct cctttatgat taattgaaca tgctctaact
     8521 ccagcttgac aagatatttc ccttggctta tcaaaattta tatctacttt ttgatgccaa
     8581 acattttcta ataaatctga tctattataa aatgcaagcg gaaaataatg tgtcaaaaaa
     8641 acatcacttt cattaggagg aacaatttta aatttaactt tgaactctcc tttagaaatc
     8701 cgctctgtta aatcaagaaa aacaggatac cattgttttt tatctgctaa aatactaccg
     8761 tcattagccc taccagtagg acaaataacc ataactgaca tatactcaat accaagcata
     8821 tcattcaatc ttatactcta aagaaaatat ctgctaaatt tgcaaacaat tgtgctatca
     8881 ataatttggc aaatgaatta gaaatacaac ttttaagttc ttttctctct gttagaaaat
     8941 gaataagata ctaagcaaca aagagctact ataccaaata ttaaataatt gctcctaata
     9001 ctaaagttat cagcaaaaat accagctagg aaatcagcta acataaaact aatcgaaata
     9061 aacaaattat atactgacca tgatactgct ctattttttt ctattgacat attaaattta
     9121 taataaaaat gattattgta gttggaatta agaacacgca ttaataaaag gattataatt
     9181 tggatgatta gattagtttg aaaaaacatg agtatagcta atactggtaa catcaagctt
     9241 acttcaaact taatttttag ataactcccc aaagccatag atatattaaa cataaatagt
     9301 ataattccca gcatatctag tgaaagtccc tgttcattta agaatatccc tgcataagaa
     9361 ttgctaatca taattagagt tgagaatgct actcctaata ttattaataa ccatggaata
     9421 ttttgaatat tatcgaggct aaaaaatttt tgtttattat tttgttcctt tttaatctcg
     9481 ggtaatccta ttaaatataa taaactgaaa attacaaata caatggatat aataatagga
     9541 taaatataat tcctatgcaa taaaggtgga gatataatcg taataatagc aataaaaata
     9601 tattttaatg tgttgagatt tttcaaaaat gatttatata caacttcgtc atcaattatt
     9661 tcaaaattat aagaaataag aactcctgaa gataatgatt ctgacaatcc aaaaaatatc
     9721 gctgaaatat atattatatt tgattttcca aacaataggc cccataatgc taaaattaat
     9781 aataaatttg aaatagccaa aattttcttg taaccaatct tacttgaaat ataacttaaa
     9841 ggaatatcaa aaactgagcc acatagctca gtaataactg ataaagtagc tatttctgtg
     9901 aacgaaaaac ctaagtgctt taatagtaaa attcctacaa agtagtacgg taatccagat
     9961 agaaacatat tcattccgta taaattaaaa atcttcttac tcataagtta caaactgggt
    10021 ctctaaaata ttttggactc ttctccttaa tcaagttaac atagcagcca ccctcgcaaa
    10081 tttttaacaa tccacaagat aaacacttag aattcttcgt tctaaaagaa cgaatccctc
    10141 catacaacgg atcatcatac caaacatcta acaaatcttt ttcaaaggca ttctgcttag
    10201 tttgattaac tcctaaaaaa gcaatgcaag gcaagatatc cccattagac attatttcca
    10261 tcttagtata ttttgcacga catccataat acatttcgcc aaactctgaa aattcaattg
    10321 aattatttat caactccgga taagcggtga aaagatgaca tccctcagta gcaaaattta
    10381 aattagcttc ccgttgagtt atataatctg taacatactc attcaacctt ctcaaatcag
    10441 ctaaatcgta ttttttcttt attttcgtat atcctgttac ctcagaataa ttagctactg
    10501 aaaatctatc tattttattc tctatacaaa aatcaaccaa ttctataatc tgctcatagc
    10561 tttgctttgt atacactgca ttaattctac atttttttcc aacctcttta aagtacttcg
    10621 ctaatttaat ttgtctatca ggtctcaccc ccattaattc aaaatttaat ttaggatcta
    10681 aagtctgcaa agataaaacc ggtgtaatat atttagattt agctagaatt tccactgtac
    10741 ttttctttat taattgggca ttagttgtta tagtagtctt tatcttcagt tcttcacaag
    10801 ctatcaacaa attatcaata tcaaaatatc tagtcggttc ccctcctaaa attgaaacac
    10861 ttaacactcc attatctttt gcttggcgca aaattctttc ccaatcttta gcaggtttgg
    10921 catttctatc ttcacgattt gctaaaaaac aaaaaccaca ttttaaatca cagtacatac
    10981 tggggtatat tactagttca agcggaaaac tcaatatgtt atgttttttt aattttgcta
    11041 catgctttct cgcattttga agagtctcgt caggattttt cgatgatccc tcaatattat
    11101 tatcagaata gatatttaat aagagtactc gctctagttt ccctgctttt atttctttct
    11161 taaaaaagga cgtagcaatt tcaaaaccat gattttgaac caaataaaga aaataagctt
    11221 cactctcatc taactcaatt cggtcaaaag ttactttatt tatcaaaatt ccaccaaact
    11281 tttctagtct aaataaaaaa tcttctgaaa ttgtcatcat attgaatacc tttctaaaaa
    11341 agcagaggaa aatatagcct ctgcttaact tatgggataa attactttat cactcccagc
    11401 cgtcaccttt tgccatcacc ttccagccgt caccttttgc cattgaacta gactcaagga
    11461 ctttttcaag ctctttagac atatttggta ctcctttcga atatgatact gtgattatat
    11521 ttcttttcaa cacttacaat aaaatattcc catatttgca ttttctaact actagctaaa
    11581 attttttcta aatgtccttc ataagtcttt gctaagtgat gacttcctgc taatttcatc
    11641 gctccaacac acttcttcat ttcaataatt gctttcacat ttccatcctc tttatattga
    11701 taaagatttt gtgcatactt aaagactaaa cgttcatata cttctgtctc aataaaaaag
    11761 cattgattta gctgcttttc aaaatataaa gcatccataa atttttctct ttcaacacat
    11821 gtaatatatc catttaaaag catcgttgaa attaatcgtc tgttatttgg aatttctttg
    11881 taaaaatcag aacgcctaaa catttctctt gctaagacca tgaaaacatc atgatttaat
    11941 acatctaaag tattcgagaa aatcaataac tcatagtacc cccagtattc tacactaaag
    12001 agataatctg ttaaatatgt caaatcatcc tttgtatagt aagtttctcc tgataaatcc
    12061 tgtagacgaa ttttcaataa aataatattg atttgatgaa atttttctcg cctatcttcc
    12121 agttccatct gagaataaag taattttttc ataccttcta cgtcacgtgt tgacacaaaa
    12181 tgacgtactt tcgataacag ttcgtttaac tcatctctat gaaaatcatg gaccgcatac
    12241 ataaattcat ctattggcat attgatttca tctaaaataa acatgaactt tgaaatcgtt
    12301 aaatctgttt ctcctttctc aaatcgagag agctgagacg ttgatatacc agcctttgcg
    12361 acgtctttta atcgtaatcc tctcgattct cgaaactttt taaaaatttc tccaaatttt
    12421 ttcatactac acctccatca cgcatatatg ggaataattt tcatttgctt tcatcatatc
    12481 atacaataaa gaaaaacaaa agtgaggatt atcacatgaa aaagcaaatt ttactaacac
    12541 ttcttcttgt cgtatttgaa ggcattatcg ttatcgtcgt gggataaaga gtctgggaca
    12601 aaagtccttt agctccaaaa agcaacggca taatgtactg accccaaaaa gttagacaaa
    12661 taatttaagt aaaggattgg aaagtcaacg aaaaactaga cacggagtta agagaattta
    12721 agaattatat ttttcaaagt cttttggaga cttgtaatca agacctgaat gcatcctttt
    12781 tgtattgtaa taggtctcaa tgta
//
