LOCUS       c00014_JAHRBE0..       14180 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHRBE010000021.1 Streptococcus thermophilus strain FDL19 Contig_21,
            whole genome shotgun sequence.
ACCESSION   JAHRBE010000021
VERSION     JAHRBE010000021
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:54:07
            Original ID  :: JAHRBE010000021.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14180
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14180
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[236:9180]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      237..9180
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14180
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14180
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             2..91
                     /locus_tag="ctg14_1"
                     /transl_table=11
                     /translation="AYIYFYNHQRFQERNNGLAPLEMRNKAVA"
     CDS             complement(237..491)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_2"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.1e-14,
                     bitscore: 46.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENLNTLDLETLASVEGGGCSWGGAGGATVQGAIGGAIGG
                     AFGGNVVLPVVGSVPGYLAGGVLGGAGGTVAYGATCWWS"
     CDS             complement(742..1143)
                     /locus_tag="ctg14_3"
                     /transl_table=11
                     /translation="MKLKNISSSVLRSFRTITAALAVFLISISLSLYKSKISPGTWLAV
                     GALAFVVIFVNGLLYRMLKKRPDSVNLLTIRQSFIVFPVITFLVLSVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLSYLQVKKYFKQ"
     CDS             complement(1473..1640)
                     /locus_tag="ctg14_4"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIVMGLANLFRSLDAVHHTINLLGLTVLLYSL
                     LFKKWVQFQK"
     CDS             complement(2148..2378)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_5"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.7e-18,
                     bitscore: 59.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGGCSWGGFAKQGVATGVGNGLRL
                     GIKTRTWQGAVAGAAGGAIVGGVGYGATCWW"
     CDS             complement(2553..2708)
                     /locus_tag="ctg14_6"
                     /transl_table=11
                     /translation="MKKYLIIFSTIAMIYLYSKVLLSSGNIYQLLLASIGFFFFLFGVY
                     RQYRKN"
     CDS             complement(2734..2934)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_7"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1e-08, bitscore:
                     28.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNKQLERFKKLDTNALSNVSGQGYGAQCVIGTTGMTIVGAAFFG
                     IAGAGAGFAGGSTAFCYDTAK"
     CDS             complement(2953..3129)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_8"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.5e-11,
                     bitscore: 37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGLSCDEGMLAVGGLGAVGGPWGA
                     VGGVLVGAALYCF"
     CDS             3379..4116
                     /locus_tag="ctg14_9"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEDAVAHELMTFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIIRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGETIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNLTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGRGC"
     CDS             4110..5450
                     /locus_tag="ctg14_10"
                     /transl_table=11
                     /translation="MLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLAF
                     NFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLITF
                     FIFPFFNISITDYQSSLLISIPSSIAPLCLSFLFIKLFKGSFTILQKQKSNSPIQHIII
                     VANFFMFGYTLLLQILMYLENTTHSSTLELRKLCVVISLVLFFIMIVFLDRNIREMIQG
                     QLDFQKNLQLENLYTYNKHIEGLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEAYDS
                     VLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGME
                     TLDFIIVTSIFLDNAIEGAIQTQNPKITISFWEDHCSQLLSISNTISEEKTETKTIFER
                     GVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     CDS             complement(5468..5629)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_11"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.6e-08,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQA"
     CDS             complement(5644..7011)
                     /locus_tag="ctg14_12"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEGLQK
                     QLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKTNTE
                     VNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQ
                     YATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQF
                     LQNAGQQLSSVETQINDTESKINQADVLLTNTLIQSPEDGILHLSQADKKATMAATGTE
                     LAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSA
                     TETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ"
     CDS             complement(7027..9180)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 306.8; E-value: 5e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_13"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1103.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.9e-45, bitscore:
                     145.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMM
                     TFARDYLLTILSQRFTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALAS
                     TILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSN
                     AMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQ
                     LILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRL
                     NEVYLIESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVG
                     VSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLE
                     NLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARAL
                     LTKSPVLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGR
                     VVETGSHQDLMSYPGFYYQLFRK"
     CDS             complement(9777..9887)
                     /locus_tag="ctg14_14"
                     /transl_table=11
                     /translation="MTQFTTELLNFGSIISVVGKTTVEIIELFEMVPPQG"
     CDS             complement(10194..11939)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     287.3; E-value: 1.4e-87)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 314; E-value: 3.3e-95)"
                     /gene_kind="transport"
                     /locus_tag="ctg14_15"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGTLSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVAIIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNI
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLI
                     DGVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKIRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     TMEGE"
     CDS             complement(11932..13689)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 389.5; E-value:
                     4.6e-118)"
                     /gene_kind="transport"
                     /locus_tag="ctg14_16"
                     /transl_table=11
                     /translation="LFFKESIIAKLWWFFKLEKRRYIVGILALSLVSVLNLIPPMVMGR
                     VIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILATSYRLGQIMRSRLFEHF
                     TKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDASITALVTLITMFFSISWQ
                     MTLVAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQEA
                     ELQSFQETNKMTFEKNMHTMKYDSLFDPLVLLFVGSSYVLTLLVGAFMIQAGQITVGNL
                     VTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIETLLEQESDVQDPAYPLPSIENGRL
                     DFAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGPTGSGKTALVKLLLREHDVNQGAIYLN
                     GHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNIRFGNPDFSIDKVEEATKLAQVYDDI
                     KDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILDDSLSAVDAKTEHAIIDN
                     LKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHDDLLAQGGWYAKTYESQQL
                     EMEGGEAHA"
     CDS             complement(13877..14083)
                     /locus_tag="ctg14_17"
                     /transl_table=11
                     /translation="MRERGQVWSYSEVKRESQLANYNTDGRYLSEATNFELYNFVREYK
                     TSDEIRRIWNPKKDESVIHDKDN"
ORIGIN
        1 tgcctacatc tatttttaca atcatcaacg ttttcaagag cgcaataacg gccttgcccc
       61 tcttgaaatg aggaacaagg ccgtcgccta atattttatt atttcattgt ccacttgaca
      121 gggagctatt caatatatgt tcaagattat tttttatgtt tatttttatt gacctttttg
      181 aaaaagatat tacctaacaa agcaacaaca aaacctataa taaaatatac catagattag
      241 ctccaccagc aggttgctcc ataggcaaca gtaccacctg caccacctag aacaccacca
      301 gctagataac caggaactga gcctacaact ggtaaaacta cattacctcc aaacgctcct
      361 ccgatagctc ctccgatagc tccttgaaca gtcgctccac ctgcgcctcc ccagctacat
      421 ccaccacctt caacactagc aagtgtttcg aggtcaaggg tgttaaggtt ttcaattgtt
      481 tgagttgcca tggcaactac cccctaaaat ttttatcgtg tgatctctca atcacatctt
      541 tagtatagca ttcaagtgtc tctatcagag ctagcgtccc aaaaagtggc tatatgtccc
      601 gaatggtaat tcctaaagaa catccttcaa tcattggaaa tcttcctcta attttcacat
      661 atttacttaa tcactttctt attataacac ttttatgcaa atatcttata gattgcttac
      721 agaataatca agcaaatgcg tttattgttt aaaatatttt ttgacttgaa ggtaagatag
      781 aaaatcacag aggattaaca aaagcattaa tacggctagt actatacggt ctgtggtatc
      841 actgaatgtt agtaatgtgt aaaactctac actaagcact agaaatgtga tgacaggaaa
      901 gacaatgaag gactgccgta ttgttaacag atttactgaa tctggacgct tcttaagcat
      961 acggtagagc agtccattaa caaaaatgac tacgaaagct agtgctccga ctgctagcca
     1021 agttcctggc gagatcttgc ttttgtagag agaaaggctg atacttataa ggaaaactgc
     1081 caacgcagca gtgatggttc taaaagatcg caatacactc gaactaatat tctttaactt
     1141 catgataaaa cacctaaact atgaataacc tcagtcagtc ttgcaaacct aataagctat
     1201 tacatttaac tctattcctc tctgtatttt attatacagc tgtaagattt caagtaagcc
     1261 cttagcgatt aaattcttct ggagatgtaa tacagtagtg tcattagtac tgatacttta
     1321 aataggcgaa tatacatatc tttgttttct ctattacaaa gatatgcaat caaatataat
     1381 ataatctccg ctatcattag caagaataat tttacttcgg gaacatcaaa aataagcatt
     1441 tgcaagcatc ttacgttcaa agtgaccaaa ggttactttt gaaactgtac ccacttttta
     1501 aaaagtaagc tataaagaag caccgttagc cctagcaagt taatggtatg gtgaactgca
     1561 tccaagcttc taaatagatt agcgaggccc attacgatga gaatggtagc cagtaaatac
     1621 ggttttgagt ttttaaacat acttttctcc ttaaagtgtt tttagctagt ctgtgcataa
     1681 tctatgaatt ttattataga ttggaagccg ataaaaaagt agtgacataa atgtcactac
     1741 ttgtctgacc ttatatcctt gataaccgta cacataagaa agagaaataa acataacccg
     1801 ataagattta ggcattgaag tccaaaattc agtttttctc caaagttatg taaggcaaca
     1861 aggacgaagc ccatagacat cattagagac actaggcgtt ttttggtcat gattacaaat
     1921 aactcttctc ttatatcgaa attttcaatc ataattcaca tgctattcac agaccagcaa
     1981 ttgacaagac atttcagtta ggatttcttc ttaacggaag atttcttctt aacggaattg
     2041 gtagccttgt gtttttcaag aaatgacata attggcttat ctaaaaaact cataacagcc
     2101 atggaaacca tccctaaaat ataacttttc aaatcaaaca taatccatca ccaccagcat
     2161 gttgctccat aaccaacacc acctacgata gcacctccag ctgctcctgc gacagcacct
     2221 tgccaagtac gtgttttgat acctagtcgt aaaccattac caactcctgt agctactcct
     2281 tgtttagcaa aacctcccca gctacatcca ccaccttcaa cactagcaag tgtttcgagg
     2341 tcaagggtgt taaagttttc aattgtttga gttgccatgg caactacctc ctaaaatttt
     2401 tatcgtgtga tctctcaatc acatctttag tatagcatac aagtgtctct atcagagcta
     2461 gcgtcccaaa aagtggctat atgtcccgag tagtaaaaaa aagactgaat atcatttttg
     2521 attcagtcca tgtcttattg aaaaagcttt aactaattct ttctatactg cctatagact
     2581 ccaaataaaa agaaaaagaa tcctattgat gctaacaaaa gttgatagat atttcctgat
     2641 gacaatagta ctttgctata taaatatatc atcgcaatag tcgaaaaaat gattaggtat
     2701 ttcttcatat gtatcacctc tctcaaatga agattattta gctgtatcat aacaaaatgc
     2761 tgtgctaccg cctgcaaatc cagctcctgc acctgcgatg ccaaagaaag ctgcaccgac
     2821 aatcgtcatt ccggtagtac caataacaca ttgagcacca tagccttgac cacttacatt
     2881 agacaatgca tttgtatcca gttttttaaa tctttcaagt tgtttattat tcataaattc
     2941 ctcccataca aattagaaac agtataaggc tgcacctact aacaccccac cgacagctcc
     3001 ccacgggcca cctactgcac caagtcctcc tactgccagc atcccctcat cacaggacaa
     3061 cccaccctca acactagcaa gtgtttcgag gtcgagggtg ttaaagtttt caattgtttg
     3121 agttgccatg gcaactacct cctaaaattt ttatcgtgtg atctctcaat cacatcttta
     3181 gtatagcatt caagtgtctc tatcagagct agcgtcccaa aaagtggcta tacgtcccga
     3241 atggtaattt ctaatgtatc cagtctctaa aattcagaaa aaattctcat tttacactca
     3301 taaaaaattg aaaaaccgtt ttctttatgt tacaattttt caataaacag tattcgtcat
     3361 aaaagagagg actagacctt gaagatttac ctattagaag ataattctat tcagatgggt
     3421 cgcttggaag atgctgtagc acatgaactt atgaccttcg gaaaagatct atcctgtgtc
     3481 cagtcttttg acaaacctga ccagttgtta tcagctatca cttctaatac aagcgatcag
     3541 attttctttc ttgatattga aattaaaggt gaagataaga agggacttga tatcgctaaa
     3601 atcatacgtc aaaataaccc ttatgctatc attgcctttg tcactacaca tatagagttc
     3661 atgcctcaag cttttggcgt tacagcctat aaatacatca ataaaacctt agatgaagct
     3721 agctttagaa aagaaatagg ggaaaccatt gctcaagtct tccctattaa cgcaactacc
     3781 acggatgagt tttttctcta caaaacagag tctcaattaa taaaccttcc tatggatcaa
     3841 attctatacc tatccacatc agatatcaaa caccatgttc acctccagac tatccatacc
     3901 ctcatggata tccgagcaaa tctggcagac tttaaaaaga tacacaaaaa gctctaccca
     3961 tgccatcggt cctatatcgt caatacagat atgattatct ctgtcaactt gaccaattat
     4021 gaagctacct taattaatgg tcaagtccta ccagtatccc gtatgaagat aggaaagatt
     4081 gcacagattg ttgaggaaag aggcagagga tgttaacaac gttatggcta ctttttctca
     4141 cccttttaag tgcaggccta gaaattattc ttttccttta tttaatggga cagaagattc
     4201 gtctgaggta ttttttccta ctccttattt ttaatttagc ctttaatttt atttataacc
     4261 actcttcttg gtttatcatt aaattctggg gtgaggatat ctattatctt cttctctcct
     4321 tccttttatc cactaagact aaaaaaccat taaaaataaa gattttcaat ggtctcttcc
     4381 ctgatatcct caacaacctt agtttaagat tgattacttt ctttatcttc ccttttttta
     4441 atattagtat caccgattat caaagctctc tattaatatc catcccttca tctattgcac
     4501 ctctttgtct atcatttctc tttattaaat tattcaaggg gagttttacc atacttcaaa
     4561 agcagaaatc aaattctccg attcaacata ttattatagt tgctaacttt tttatgtttg
     4621 ggtacaccct actgttacag atcctcatgt atcttgaaaa cactactcat tcttcaactt
     4681 tggagcttcg aaaactctgt gttgttattt cacttgtcct cttcttcatt atgattgtct
     4741 ttttagacag aaacattcgt gaaatgattc aaggacaatt ggacttccaa aaaaatctcc
     4801 agctagaaaa tctctacacc tacaataaac atattgaagg tctctacaat tctgttcgta
     4861 gttttagaca cgattatagt aatctcttag tcacattacg attggggata gataaagacg
     4921 atatggatat tgtcaaagaa gcctatgata gtgtgcttca agaatccgat aaacgattaa
     4981 atacaagaaa ctttgactta gctagactcg ttaatattca ggataacact ttgaaaagcc
     5041 ttctgtccgc aaaagttcta caagcagaag aagaaggcat tgaagctcag attagcatcc
     5101 cagaacccat ccacttgatt gggatggaga ctctggactt cattatcgtc acttctattt
     5161 ttttagataa cgctattgaa ggtgccattc aaactcaaaa ccctaaaatt actattagct
     5221 tttgggaaga tcattgttca cagctattat ctattagcaa taccataagt gaagaaaaaa
     5281 cagaaaccaa aaccatattt gaaagaggtg tctccaacaa gggacgagag cgaggcattg
     5341 gccttgctaa tgtcacagaa atcttagata actatatcaa tgtaaactta gaaacacaga
     5401 gtaacaattt ctcattcaca caacaattaa caataactaa aaaggcctaa cagccttttt
     5461 tctataccta agcttgagga atgttatagt cttttgttgg aagcgttctt tgccctccga
     5521 atccttttag gaaaccattt atataatcca tccacccact tccacctacg acttgttcaa
     5581 gagcgtggtt atcaagtgtt tcaaagttat taatcgtatt gttagccatc agtaattctc
     5641 ctcctattgg tcttgcaagt ttagtaactt gtctttaaag taattgaagt aggtcttttg
     5701 gtcaataacg cttgtcacac gaccttctag accgtaacgt agattttggg cttctttttc
     5761 tgaaatactt gccctagcag ttactctaaa cacattcccc ctttctgttt ccgtggcaga
     5821 attatcaata ctctcaagtt ttccaataat tgtggtaccg tgattaccaa ccttatccaa
     5881 ggtcagtcga actgactggc ctttttgcag ttttggcaca taatccgaat tcacataata
     5941 agtaatggca acttcctggg tttgagtcat atcgggataa agctgggcca actcagttcc
     6001 tgtcgcagcc atggttgctt ttttatcagc ttgactcaag tgtaagattc catcttctgg
     6061 tgactggatg agggtattag tcagaaggac atctgcctga ttgattttac tctcggtatc
     6121 gttaatttgt gtttccactg agctcaattg ctgtcctgca ttttgcaaga attgattttt
     6181 tagagcttct tttttagtgc tatcactatt gtcataagtt acaactgtgc ctgtcccagc
     6241 cttttggatt tctagattac ctatggaagc attcaagctc gaaatattgg tattaacttg
     6301 agataggtat tggtctgtta cactggcatc cggtgtcgta gcatactgac tgttataggc
     6361 atttaaggtt gcctgatgag gattgccttc aggtaaagtc gtttcatgat tggtaatagc
     6421 ttgagagagc gcctcatact ctgagacctg agtctgcaat tgactaatct ggttatcaat
     6481 agcagaaccg gtattactcg caattgctgc ttggttatta acctctgtat ttgttttagc
     6541 cacacccaag tcaatatcct gtgcctgact taggtaggtg ttaaaagtac tctgataacc
     6601 aaactcgtct tcctgttctt ggaaaagatt ggttccctgc gttaggctag attgcaaggt
     6661 cttcaaacct gattcctgtc tttttaaaag ttctagttgc ttttgaagcc cctctttttg
     6721 cgatgcctcc atggtctctg aatactgaac taaggtgtcc ccttttttaa caaccttatt
     6781 agcaaccagt tgattatcta tgatggtatt gtcactggtt gattggatta ctgcgataac
     6841 cttggttggc tctatacttc ctctagacgt gactgtaact tccttcttag caaaaaaagc
     6901 gaaaagaaaa aggaaaataa ctaacaaaat caagggagta atcaaaacag tagacatatt
     6961 gtggtagcga cgatggtaaa actctgtgct tttaaacaac tgtggattca tcgtgtttcc
     7021 ttttcctcac tttctaaata attgataata gaaacctgga taagacatta ggtcttgatg
     7081 agaacctgtc tccactacgc gtccgtgatc aatgactacg atacggtcgg tccgctcagc
     7141 gatactaagc ctgtgtgcta caaagatgat cgttttatct tttagtgcta ggaggttatc
     7201 aataacctgc ttttctgtca aaacatccaa tccgctagtt gcttcatcta agattagtac
     7261 aggagatttc gttagtagtg cacgcgccaa agcgatacgt tgcttttgcc ctccagacag
     7321 acctgctcca tcagacagct ctgtctgaaa ccccataggc atgttttcaa tatcttgacg
     7381 aatttctgct atttcacaag ctttcaaaat atcagcttgc gtaatacccc gtgctgcacc
     7441 taaagtaaga ttttctaaaa cactaccact aaatatatag gattgctgag ggagatagtt
     7501 aatatgttga cgaagagttt tcttgtctat gcgactaata ttttgaccat taaaatctat
     7561 gtgcccctta tatggttgat aaaaattgac caacatttta gctagagtag tcttaccaga
     7621 tccactgaca ccaacaaaac tgattttttc tccttgtcta atcgtcaaac tgacatcagt
     7681 caaagtatca cgaccaaaac catatttata agataaatcc gtaacagtga tatctccatc
     7741 cgcaatgcct tcttgatagg tatcatcact ttgtccaaac tctgattcaa tcagatagac
     7801 ctcattgagc ctagtattag ctaccttagc agactgtaac ttggtttgca ggttaatgat
     7861 attttccaaa ggattcgtga agtaagaaag caacatatta aaagtaatca attgtcctat
     7921 cgaaatggta tttcccatca ccaactgagc acctgtccag aggataagta catttaaaat
     7981 aagttgagca ccttgtttca atgatgtttg tagtatagat aacttagaaa ggcgaaaaga
     8041 attgtctaga tagtcaataa actcaccatc aatcttttga tagcatactt cttcgctggt
     8101 tagtgacttt atggtttcaa tcccattaat gtcctcaatg atggctgaat taaccatagc
     8161 attactctgc atgacgtcat gattcattcg ctcaaaaggt ttcataaagg caaagacgat
     8221 aagggtataa attggaaccg aacaaagaac tagcttgaag agattgctat tttgtatcaa
     8281 taagacgcct cctacgataa tcacaataga gaaatcaagg aaaagtgata atatcgtcga
     8341 agccagagca tcgataatag agttagcatc actaaaacgt gagataacct cccctgtacg
     8401 tcttgtggca aaaaaagaca ttgggagttc aaagatatgt cgtatgtagg acaagataac
     8461 gtcaatggta aatcgctgac tcagtatggt taagagataa tctcttgcaa aagtcatcat
     8521 ttgttgtaaa acataggtca caactaatcc aattgagata attcctaagg tagacttcat
     8581 ttgattaggg acatattcgt ctagaatacc ttgtaaataa taggaaccta aaatatttat
     8641 taaagtaacc aagagactgg caaagacaat attagctatc aaggaccttt gtttaaagat
     8701 caaagggaga aagtcccaga gtccattttt cttatcctta tgtggtttat aactgggttc
     8761 cggtcccata aaaagagtaa cacctgtcca ctctttctca aaacgctctt tagtcatttt
     8821 agttactttt acacttggat cagggtctcc aattatcaga taatccttgg tgcttttata
     8881 aataacataa taatgttgaa gcttcccatc tttattaaca tgagcaataa aaggataagg
     8941 aacatcttcc atctcaaaga gcgacatttc agcctttata gctctcgttt caaagccaat
     9001 ttttttagca gcctctacaa gacctaaggc agttgtccct tctttattgg tcttcgccaa
     9061 ctcacgcaga tgtgctaatg aataatctga accatagtac ttggccactg atgccaaggc
     9121 agcaactcca caatccctca tgtctatttg agggacaaaa gtcctacgaa aacgaaacat
     9181 accaaaccct ttcatcacaa attatcatat gattagtatg tcatattttc aggataaaaa
     9241 gagccagcgt cccaaaaagt tgccatacgt cccaaacggt aagaaaaatc ttaaagtcat
     9301 ctccactatt accatttaag ccgtatttgg ggtcatttag gacaagttca ttgaaatcga
     9361 tttcaaagtt atacaatagt tattagaagg aaacattcta aaatagtcct acaagcatac
     9421 gtatttgatc taaccattat tactgtgcca gccctggtat ttccaaagga aaccatgact
     9481 gctgatagcc tcggagccta tctctatcgt atgatgtcat aatttgatta tttttattcc
     9541 gaaaagggat aacattatga aaaacgtcaa tccatatctc aaaaaatcct atcaaaaaag
     9601 gctaaatcag cctcttgaga ttcgattact caattatcgg tttaattttc cttagctttg
     9661 taagtgtatt tgttatcact gtcaatgcta tttttagcgt cactagaggg gttcccttcc
     9721 ttaatgccca ccttatttcc accttgagta attgtgcctt ctatcttttg atttactcaa
     9781 ccttgaggtg gcaccatctc aaaaagctct ataatctcta cagtggtttt tcccactaca
     9841 gaaattatag agccgaagtt aagtagttct gtggtaaact gagtcatagg aataaatctc
     9901 tttctagtaa tgttttgcaa ctctactata acggatttat tcctttttgt gtttacacaa
     9961 cttattttac actacctcaa cgtttgcaag tacctcgaga tcgagtgttt caaatgtatt
    10021 atttgtttgc cttgtcattc taacaacctc ctaaattatt tttagctttt tctctcaagc
    10081 tatgatttta ttatagggtg gtagccaaca aaaaagtagt gacataaatg tcactactcg
    10141 attttgattt ttaagaaatc ttttcgaata tagaagctat ggtctagatt agcttactct
    10201 ccttccatgg tgcctgcttg taggctgtac atcttgtgat aggtgccgcc gagggctagg
    10261 agctcttcgt ggctaccgtg ttcaatgatg cggcccttgt ctaagacata gatgcagtta
    10321 gcatcttgga ttgttgatag gcggtgggca atggcaatgg ttgtacggcc ttgacgaatt
    10381 tttgcaagag agttttgaac aatagcctct gtctccgaat caatattggc tgtcgcttca
    10441 tccaaaatca agattttagg ctggctagca acggttctag caaaggctag aagctggcgt
    10501 tgaccggttg agaaacttga accacgttcg gaaactgggg aatcatagcc ttcaggaagt
    10561 ttatcaataa agtgattggc atcgacaaac tcagcagcag ctttaatctc ttcatcagtt
    10621 aaatcttgat acatggcaat attggatttg attgtgccat gatagaggaa ggggtcctga
    10681 aggacaagac caatattctt gcgcagctct gcctgactat aatcacgaat atccacaccg
    10741 tctatgagaa ctcgtcctga ttggaattca tagaatcgca tgagcacgtt gataatagag
    10801 gattttccag agcctgtaga tcccacaaag gcgatggttt cacctttatt gacagagaag
    10861 gaaatattat ccaaaatctg gtgcttgcca tcataggaga aggagacatt ctcaaagcga
    10921 atattcccct cagtaacctt ggcagctgtg tctctctgtt caggctcata ggtacgctcg
    10981 tcaatcaagg caaagacccg acctgctgag accatagagg tttgtagagt cgagaagttt
    11041 tgtgtcactt caatcaaggg atcaaagagg cgattaatat actggataaa ggcatacatg
    11101 gtacctgctg tgatacccag atagatacct cggtagccaa aataggccat gagaacagca
    11161 taagccagga gcttcagtag actcatggct gggcgtagaa agagagaatc cagtgatata
    11221 gaacggctgg cataaatcag gtgttcctca ttaatggcat caaactcttt tttaagacgc
    11281 ttctcctggt taaaggcctg aatgatgtga atcccttcga tactctctga cagtttggca
    11341 tttatatctg aaagcaaggc tctggtcttt tcaatgatgg ccactgattt tttgcgataa
    11401 aggttaacca aaaggacaat cagaggaaga aagaggacaa taagcccggt cagacgaatg
    11461 tccaagatca tcatggtgta aagggtggta acaaagataa agatagccga aataaaacta
    11521 gacagagttc ctgagaacat ctcgctaatg gtctcagtat cattggtcaa gcgggaaacg
    11581 atggaacctg ctggggtctt gtcaaagtaa gacataccca gtttttccat attggcaaag
    11641 gcatctcgac gaatatctct gacaatgcta taggacacac gcgcaaagaa gagatttccc
    11701 agatactgga ctagtgtctg caagaggtag agaccatagt agccaatcag aatcatactt
    11761 gccgcctgat tcatatcatg aagatagtga tcaataaaat aagaggccac caagggaatg
    11821 atactcttga taaccgttgt ggacaagagg aaggtcaaag ctagaaaggt caagaacttg
    11881 taaggcttga gataggtcaa gagacgctta aacacagacc attggttttg attaggcatg
    11941 agcttctcct ccttccattt ctaactgttg agactcatag gtcttggcat accaaccacc
    12001 ttgagctagt aagtcgtcat gacgcccacg ttcaatgata cgaccatctt gcatgaccag
    12061 gatgaggtca gcgtgcacca ccgcactgag acggtgggcg gtaataatag ttgttttgtc
    12121 cttgcgagta tgcttaagat tatcaataat ggcatgttct gtcttagcat caaccgcaga
    12181 taaggagtca tccaaaatca aaatttctgg attcaaaatc atggcccggc tcatagccag
    12241 acgttgtttt tgaccacctg ataggctgac acccttttca ccaatgattg tttcaaagcc
    12301 ttcaggcata tccttgatat catcataaac ttgagctaac ttagtcgctt cttccacctt
    12361 atcaatggag aaatctggat taccaaagcg gatattgtct aaaatagaac tggcaaagag
    12421 aaactggtct tgaggaacat aaccaatcaa gctacgcaag tctgataggc gatagtctcg
    12481 gatgtcatgt ccattcaaat agatggctcc ttgattgaca tcgtgctccc gcaagagcaa
    12541 cttgacaaga gccgtctttc ctgagccagt cggtccaacc aaaccaaggg tttgcccctt
    12601 gtccaaggtg aaatgaatat ctcgcaaagt atcctcatcc tcaaaagcaa agcggtcaat
    12661 cgcaaagtct aaacgaccat tttcaatgct tggaagagga taagcgggat cttgaacatc
    12721 tgattcctgc tctaaaagag tctcgatacg ttggtaggac acatttcccc tctgcgtgat
    12781 attaaagagg aagccaatgg ccattagggg ccaaaccagc atgtccaaat aggtaataaa
    12841 ggttaccaaa tttccgaccg ttatctgacc ggcctgaatc ataaaagccc cgacaaggag
    12901 ggtcaaaaca taagatgagc caacaaagag caagaccaaa ggatcaaaaa ggctgtcata
    12961 cttcatagta tgcatattct tttcaaaagt catcttattg gtctcttgga aggactggag
    13021 ctcagcctcc tgatagccaa aagacttggt taccttgata cctgacaccg attcttgtac
    13081 cttattatta agttcagaaa aagctgcctg ggattctcca aaagctttgt gggtcttacg
    13141 tcccaaacga ctagtcgcaa aagccatgaa aggtagaggt aagactgcca ccagggtcat
    13201 ctgccaggaa atgctgaaga acatggtgat taaagtcacc aaggctgtga tagacgcatc
    13261 cacggctgac atgacacccc caccagccaa acgggttaga gagttgatat cattggtggc
    13321 atgggccatg agatcaccag ttcggtactt ttggtaaaaa gaaggcgaca tcttggtaaa
    13381 atgctcaaaa agccgcgaac gcataatctg tcccaagcga taagacgttg ccaagatata
    13441 catccgccaa acatagcgca aatagtacat tcctaaagcc gccaaaagca aataaacgag
    13501 attcaaaagc aagatctgat tggtcaattt tcccgatgtg atagcatcaa tgacccgacc
    13561 cataaccata ggaggaatca gattgagaac cgaaaccaaa ctcagtgcca atatcccgac
    13621 aatataacgg cgtttttcta acttgaaaaa ccaccaaagt tttgcaatga ttgattcttt
    13681 aaaaaacaag ttattccccc tatccctaca aaaggatgat tataagtcta atgaaagtta
    13741 tttccaatag cgataaattg taccatcttc taactgaaag tgaccaatat aagtcaattt
    13801 tccaaaatca gtagactctg gcaatttata agcaaaggag tcaaaattat aggccttgtg
    13861 cccatcatca atagaatcag ttatccttat cgtggataac tgattcgtcc ttcttagggt
    13921 tccaaatacg tctgatttca tcagatgtct tatactctct gacaaaattg tacaattcga
    13981 agttagttgc ctcactgaga tagcgaccat cagtgttgta gttagctaat tgagactctc
    14041 tcttaacctc agaatagctc caaacctgcc ctctttctcg cataataccg gcatcacggc
    14101 cacttttgat aagtatctgc tttaaccgtt gtcattgttg ctcctagtgt caatacggtg
    14161 actactgtca cattaagtgt
//
