LOCUS       c00016_JAHRBD0..       17683 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAHRBD010000023.1 Streptococcus thermophilus strain Moz76 Contig_23,
            whole genome shotgun sequence.
ACCESSION   JAHRBD010000023
VERSION     JAHRBD010000023
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 01:56:49
            Original ID  :: JAHRBD010000023.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17683
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17683
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5258:7683]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5259..7683
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17683
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17683
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             3..677
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 188.8; E-value:
                     2e-57)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_1"
                     /transl_table=11
                     /translation="MSNLIFDSVTKIFGEGGSKYVALENINFEAESGQLILVVGPSGSG
                     KTTFLTIAGGLQTPTNGDVKINDSTINSLSKKQQTKLRLEKIGFILQSYNLVPFLTVEE
                     QFKFVDKLKKQNLTEQKLHELLSDLGLLELLKKYPNQLSGGQKQRVAIARALYTDPDYI
                     LADEPTAALDTDRSMKVIELLRDLAHKRNKIIIVVTHDLRLKDMADKVYQIIDGKMTIL
                     EK"
     CDS             1849..2148
                     /locus_tag="ctg16_2"
                     /transl_table=11
                     /translation="LCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(2248..3159)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_3"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(3389..3478)
                     /locus_tag="ctg16_4"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(3475..4077)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_5"
                     /sec_met_domain="TIGR04085 (E-value: 3.5e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1e-12, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALKLDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(4171..5262)
                     /locus_tag="ctg16_6"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(5259..6578)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_7"
                     /sec_met_domain="PF04055 (E-value: 1.5e-19, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.4e-06, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.2e-13, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 3e-24, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(6648..6740)
                     /locus_tag="ctg16_8"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6823..7683)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_9"
                     /sec_met_domain="TIGR01716 (E-value: 1.5e-50, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7923..8735)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.8; E-value: 2.9e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg16_10"
                     /transl_table=11
                     /translation="MLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIFTEHKGNYG
                     YRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAENLIQRQFE
                     ASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQVKAMLEQAF
                     TEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESFFGILKSEM
                     FYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8753..9319)
                     /locus_tag="ctg16_11"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(9498..9656)
                     /locus_tag="ctg16_12"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9977..10441)
                     /locus_tag="ctg16_13"
                     /transl_table=11
                     /translation="VKSLSISSSFFSISTSSTPQLTANSIGQHSTAKQSRKEIELAAAK
                     LVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQPYMTESAYSQELTSQNDAM
                     NQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSDLKNANQSKTN"
     CDS             complement(10721..13900)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 496.3; E-value: 3.2e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg16_14"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDRFQKSLEERLRQSNKDMDKRQAQIDSHFASQVWSE
                     EELTVLASTPASEKLARLEEFLSQRQESLTEQKSILKAAHEDLAQLQKSFQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELAIQSEDFLQKEEELETWKEDIIYSQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLESLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLMIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVTKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIRKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13897..15105)
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.9; E-value: 5.9e-77)"
                     /gene_kind="other"
                     /locus_tag="ctg16_15"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMKKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 tcatgtcaaa tctcattttc gactcagtca caaaaatttt tggtgagggg ggtagtaagt
       61 acgtagcact agaaaatatt aatttcgaag cagaaagcgg tcagcttatt ttagttgtag
      121 ggccatcagg atcaggaaaa actacatttt tgactatagc aggcggacta cagacaccaa
      181 ctaatggtga cgtaaaaata aatgacagta caattaacag tttgtccaaa aaacaacaaa
      241 caaaattaag attggaaaaa ataggattta ttttacaatc ttataactta gtcccatttt
      301 taacggtcga agaacagttt aaattcgtag ataaactaaa aaaacaaaat ttgactgaac
      361 aaaaattgca tgagcttctt tctgatttag gacttttaga actgctaaaa aaatatccta
      421 atcaactttc tggtggacaa aagcagcgtg tggcaattgc tagagcatta tacactgatc
      481 ctgactatat tttagcagat gaacccacag ccgcattaga tacagataga tccatgaaag
      541 taatcgagtt actcagagat ttagcgcaca aaagaaataa aattattatt gtagttactc
      601 atgacttaag gttaaaagat atggcagaca aagtttatca gataattgac ggtaaaatga
      661 caatcctgga gaagtaattt aatttatgac taaaaatcag caaaaatata attatgacta
      721 aggaatatat tattaactaa atgttgagat agcacaagga aatatttgtg ctatcttttt
      781 tatttattag gaaaagagaa aaaattatgc caacgaaaat atggttaaaa ccagaacaat
      841 tagatttgta tattaaacat ttagaacgat ttagagactt atatagtaaa ctagactgtt
      901 ctggtatagt aaatttgtaa cactcctacc taataagtta aactattcat tagaatagga
      961 gacataacat gaaacactat ccagacgaaa cacgataaaa aattgttcga ctgcacattc
     1021 aagacggatg aacattaaaa agcttagctg ctgaatatgg cgtatcccaa gcctcaatct
     1081 ctaattgggt aagacattat cgcaaagaat gccaaactaa taataaagaa aaatcacagc
     1141 ttgaactcat ggaggaggtt cgtaaattac gtcaagaaaa ggcagagctt gaaaaggaaa
     1201 atgatttctt aaaaaaagca gcggcattct ttgcaaagga aatcgattag aggcatatcg
     1261 ttttattgat aactataaag aagattttgg tttgcgttgg ttgttcttgc atatgaatat
     1321 tcatcccaat gcttattata attatcttaa aaagacaagg actaactatc atcgtcaaaa
     1381 gaaagctatt cttaatacta ttcgagatat ctaccatgag tgcaatggaa agaagtaaat
     1441 caattcttcg aaacagaaag catcaaactt tctgatatag agccttcgaa agttagttat
     1501 agggaggtac aaaggaatca aatcaatacc actatttata atgaaaaagg taatataaag
     1561 gatattgata ctagcattat aagagatatg tacgataaaa gcaaacctac tttaaaacag
     1621 ggagcctata tatccgctat agcagcttct ctagaagggg ggtactgcat ttataacagc
     1681 aataattaaa aaaagcgctt agggaaaact attagtgagt ttacaaaaga cgattgtctt
     1741 gaaatttcta aagatagtgg aattggagct ataaaaggaa gtactcgagg cattacgata
     1801 tacgccctaa cgaattacac agctactcct gcagcagtag caagttcatt gtgcactgct
     1861 tcatttggta tcgctaaaga agcatacaaa ttccgtaaaa acttaatcac aaaagaagaa
     1921 tttttactaa attcgcaaat attatgtgtt gaagtatcag ttagtgcatt atcctcaata
     1981 ttaggacatg ctgtaattcc aatacctatt ttaggatccg ttattggaaa taatatagga
     2041 actttcctat atgaaatcgc taaagataat ctcacaatga aagagaaatt actgatagca
     2101 gattatttca aagagataca agaatataac tattttttag ataattaatt tgaattatat
     2161 aatcatcaac ttcagagaga ttaagaatta ctataaactt ttagggaagg cattttctcc
     2221 tgactataat atcgcttttc agggatctta tgaattttta aatatgtttt ttaaaaatac
     2281 gttaacctct cctattttct ctgcttcagg taaatagata gaaacggttg tcgaataaac
     2341 aaaagaaggt acactcacaa ttgaaagcaa ttgactaata actgcataaa tagccaacaa
     2401 ttctactcct aatctcgaca tcaaggcatc aaacaccata ataaacaaaa cactctccag
     2461 aatttcttga ccaaccaaag gaataccaaa tgttattaat tcaaatttag ttgtagatgt
     2521 aatggataaa gccttcaaaa tcattggata aaccataaac aagtaactaa gcgatatgaa
     2581 agctaaggat acaatcgttg atatggctgc tcccttaatt ccgatttgtg gtaccagtac
     2641 ataatttaac acaacatcta ttaatgaact gataagtcca acccacataa ttggttttgt
     2701 tttcttttga actcttaata aatttgtcag cgaaaagttt aataatgtca atccgatata
     2761 tggagacatg aagactaaat aaatggtgga taaggacaat agttgccctt taaatccata
     2821 gagctgcttc aagattacat ttccaaaaat aatgacaaaa accgcaaagg caactccgat
     2881 aattaaatct aaggttagat ttgatttcaa taaatcatca aacctgttag tttgccgatt
     2941 agagtacgcc ttagagcttt taatattaaa tgacaaactg aatgctccta aaagtccacc
     3001 aaaagcaaat aagagattct gaataatgga aattcctgac agagcaattg aggaattgtt
     3061 cacagcaaaa tgcaatgcta tctgcccaat aattacttga ccaatatttg ttaaaactaa
     3121 gggaaaggca aatttgttaa tttcttttga atctatcatt tttcctctct aaaaggcttc
     3181 aaatgtaagt aaagatcaga tttaactaaa tttgcataaa taatatgcaa aataggagtt
     3241 tcttctaaaa atgaaataat tgcctgctta caatcattag cagatacctc ataatcttgc
     3301 tgtaatagtt ctacaatctt gtctaaagaa aaatttttag aaatgcaata aagtatttct
     3361 gctcctattt catcaaatga atagtactct aatcaagtag atcgtatcct atgtattcat
     3421 ctgctacttt atttacaatg aaatctctct tacctcttat cacaaaatgt tctttcatac
     3481 gactactcca cctccttttt gttcataaaa gcaggctaaa tcagagccca gtaacgttcc
     3541 atctaatttc aaggcactgc atcgacatcc cccaccacac catggtaggg gacattctga
     3601 acatttccca gaaatatcat caaatgtaat tgatcttagt ttattaaata cagcagaatg
     3661 gtgccaaatt tcgctaaact tttgttcttt aacatttcca gcaactaatt catctatacc
     3721 attcatcaag tcacacccgt atacatctcc tttatgatta attgaacatg ctctaactcc
     3781 agcttgacaa gatatttccc ttggcttatc aaaatttata tctacttttt gatgccaaac
     3841 attttctaat aaatctgatc tattataaaa tgcaagcgga aaataatgtg tcaaaaaaac
     3901 atcactttca ttaggaggaa caattttaaa tttaactttg aactctcctt tagaaatccg
     3961 ctctgttaaa tcaagaaaaa caggatacca ttgtttttta tctgctaaaa tactaccgtc
     4021 attagcccta ccagtaggac aaataaccat aactgacata tactcaatac caagcatatc
     4081 attcaatctt atactctaaa gaaaatatct gctaaatttg caaacaattg tgctatcaat
     4141 aatttggcaa atgaattaga aatacaactt ttaagttctt ttctctctgt tagaaaatga
     4201 ataagatact aagcaacaaa gagctactat accaaatatt aaataattgc tcctaatact
     4261 aaagttatca gcaaaaatac cagctaggaa atcagctaac ataaaactaa tcgaaataaa
     4321 caaattatat actgaccatg atactgctct atttttttct attgacatat taaatttata
     4381 ataaaaatga ttattgtagt tggaattaag aacacgcatt aataaaagga ttataatttg
     4441 gatgattaga ttagtttgaa aaaacatgag tatagctaat actggtaaca tcaagcttac
     4501 ttcaaactta atttttagat aactccccaa agccatagat atattaaaca taaatagtat
     4561 aattcccagc atatctagtg aaagtccctg ttcatttaag aatatccctg cataagaatt
     4621 gctaatcata attagagttg agaatgctac tcctaatatt attaataacc atggaatatt
     4681 ttgaatatta tcgaggctaa aaaatttttg tttattattt tgttcctttt taatctcggg
     4741 taatcctatt aaatataata aactgaaaat tacaaataca atggatataa taataggata
     4801 aatataattc ctatgcaata aaggtggaga tataatcgta ataatagcaa taaaaatata
     4861 ttttaatgtg ttgagatttt tcaaaaatga tttatataca acttcgtcat caattatttc
     4921 aaaattataa gaaataagaa ctcctgaaga taatgattct gacaatccaa aaaatatcgc
     4981 tgaaatatat attatatttg attttccaaa caataggccc cataatgcta aaattaataa
     5041 taaatttgaa atagccaaaa ttttcttgta accaatctta cttgaaatat aacttaaagg
     5101 aatatcaaaa actgagccac atagctcagt aataactgat aaagtagcta tttctgtgaa
     5161 cgaaaaacct aagtgcttta atagtaaaat tcctacaaag tagtacggta atccagatag
     5221 aaacatattc attccgtata aattaaaaat cttcttactc ataagttaca aactgggtct
     5281 ctaaaatatt ttggactctt ctccttaatc aagttaacat agcagccacc ctcgcaaatt
     5341 tttaacaatc cacaagataa acacttagaa ttcttcgttc taaaagaacg aatccctcca
     5401 tacaacggat catcatacca aacatctaac aaatcttttt caaaggcatt ctgcttagtt
     5461 tgattaactc ctaaaaaagc aatgcaaggc aagatatccc cattagacat tatttccatc
     5521 ttagtatatt ttgcacgaca tccataatac atttcgccaa actctgaaaa ttcaattgaa
     5581 ttatttatca actccggata agcggtgaaa agatgacatc cctcagtagc aaaatttaaa
     5641 ttagcttccc gttgagttat ataatctgta acatactcat tcaaccttct caaatcagct
     5701 aaatcgtatt ttttctttat tttcgtatat cctgttacct cagaataatt agctactgaa
     5761 aatctatcta ttttattctc tatacaaaaa tcaaccaatt ctataatctg ctcatagctt
     5821 tgctttgtat acactgcatt aattctacat ttttttccaa cctctttaaa gtacttcgct
     5881 aatttaattt gtctatcagg tctcaccccc attaattcaa aatttaattt aggatctaaa
     5941 gtctgcaaag ataaaaccgg tgtaatatat ttagatttag ctagaatttc cactgtactt
     6001 ttctttatta attgggcatt agttgttata gtagtcttta tcttcagttc ttcacaagct
     6061 atcaacaaat tatcaatatc aaaatatcta gtcggttccc ctcctaaaat tgaaacactt
     6121 aacactccat tatcttttgc ttggcgcaaa attctttccc aatctttagc aggtttggca
     6181 tttctatctt cacgatttgc taaaaaacaa aaaccacatt ttaaatcaca gtacatactg
     6241 gggtatatta ctagttcaag cggaaaactc aatatgttat gtttttttaa ttttgctaca
     6301 tgctttctcg cattttgaag agtctcgtca ggatttttcg atgatccctc aatattatta
     6361 tcagaataga tatttaataa gagtactcgc tctagtttcc ctgcttttat ttctttctta
     6421 aaaaaggacg tagcaatttc aaaaccatga ttttgaacca aataaagaaa ataagcttca
     6481 ctctcatcta actcaattcg gtcaaaagtt actttattta tcaaaattcc accaaacttt
     6541 tctagtctaa ataaaaaatc ttctgaaatt gtcatcatat tgaatacctt tctaaaaaag
     6601 cagaggaaaa tatagcctct gcttaactta tgggataaat tactttatca ctcccagccg
     6661 tcaccttttg ccatcacctt ccagccgtca ccttttgcca ttgaactaga ctcaaggact
     6721 ttttcaagct ctttagacat atttggtact cctttcgaat atgatactgt gattatattt
     6781 cttttcaaca cttacaataa aatattccca tatttgcatt ttctaactac tagctaaaat
     6841 tttttctaaa tgtccttcat aagtctttgc taagtgatga cttcctgcta atttcatcgc
     6901 tccaacacac ttcttcattt caataattgc tttcacattt ccatcctctt tatattgata
     6961 aagattttgt gcatacttaa agactaaacg ttcatatact tctgtctcaa taaaaaagca
     7021 ttgatttagc tgcttttcaa aatataaagc atccataaat ttttctcttt caacacatgt
     7081 aatatatcca tttaaaagca tcgttgaaat taatcgtctg ttatttggaa tttctttgta
     7141 aaaatcagaa cgcctaaaca tttctcttgc taagaccatg aaaacatcat gatttaatac
     7201 atctaaagta ttcgagaaaa tcaataactc atagtacccc cagtattcta cactaaagag
     7261 ataatctgtt aaatatgtca aatcatcctt tgtatagtaa gtttctcctg ataaatcctg
     7321 tagacgaatt ttcaataaaa taatattgat ttgatgaaat ttttctcgcc tatcttccag
     7381 ttccatctga gaataaagta attttttcat accttctacg tcacgtgttg acacaaaatg
     7441 acgtactttc gataacagtt cgtttaactc atctctatga aaatcatgga ccgcatacat
     7501 aaattcatct attggcatat tgatttcatc taaaataaac atgaactttg aaatcgttaa
     7561 atctgtttct cctttctcaa atcgagagag ctgagacgtt gatataccag cctttgcgac
     7621 gtcttttaat cgtaatcctc tcgattctcg aaacttttta aaaatttctc caaatttttt
     7681 catactacac ctccatcacg catatatggg aataattttc atttgctttc atcatatcat
     7741 acaataaaga aaaacaaaag tgaggattat cacatgaaaa agcaaatttt actaacactt
     7801 cttcttgtcg tatttgaagg cattatcgtt atcgtcgtgg gataaagagt ctgggacaaa
     7861 agtcctttag ctccaaaaag caacggcata atgtactgac cccaaaaagt tagacaaata
     7921 atttaagtaa aggatttagt tctgtattgt acaggactga gtccttttag ttttacctta
     7981 atgcgtttgt tgttgtaata attaatatag tctgcaattg cttgttccaa atgctcaatt
     8041 gacttaaacg tcttctcata accataaaac atctcagact taagaatgcc aaagaaggat
     8101 tccatcatgc cgttgtctgg actattgcct ttacgtgaca tggatggttg gattcctttc
     8161 tcctctaaaa aatgatgata gaaatcatgt tgatattgcc atccctggtc actatggaga
     8221 attgtatttt tgtaatgttt ctctgtaaag gcttgttcta acatagcttt cacttgtatc
     8281 aagttcggtg acttagaaag attgtaggcg ataatttcac tattgaagcc atctaaaatt
     8341 ggcgacaaat agagtttttg gctgcttgct ggaatggcaa attctgttac atctgtgtag
     8401 catttttcca atggtttgga tgcttcgaac tggcgttgga tgagattctc tgctttcata
     8461 ccaacctctc cttgatatga agaatactta cgtttacggc gaattctagc ggttaaacca
     8521 agtactttca taagacgttg aactctctta tgattaatca caattcctcg atttctcaat
     8581 tcaagagtca ttcgacgata gccgtaattt cctttatgct cagtaaaaat ggcttgaatt
     8641 tcagctttaa tgtcataatc cttatcattt tgatccagct gttttaagtg gtaataatag
     8701 gttgaacgag caagcttaat aatctttaga agcatatcta aagaaaactc agttaccaat
     8761 cctcggacaa tttccgtttt tcttcttgct ctttttcttc cctcaatcgg agttctctca
     8821 actttttaag aactgcattc tccgctctaa ggtactcatt ttctgcttga agacgttcca
     8881 tttcttccag ttttttcttt ggcttacgtc ccattttaga taaccttcct cttgttttct
     8941 caacaatagt atacccgttt ttcttatagt gtgcgagcca gttaggaagc gtcccacgat
     9001 ttgggagagc atattcaaga gaaactctat cttgagaata gcctttatat aggactttat
     9061 caatcatttc ttgttttaat tcaggagagt agtaacgatt ctttcctttt ttagcgattt
     9121 ctattccgta tcgatcaatc aatttaatca tgtagctaag attagaaatg tttatcccaa
     9181 atttatttga aagctgatct aagctatatc cttggtttct aagttcatag atttgaacct
     9241 tatcttcata agtcaatttc ataataaaaa caccccgaaa gttagatttt ttctgtctaa
     9301 cttttggggt gcagttcata aaaccgttgc tttttgcatg attgtgatag acttggtgaa
     9361 atagaattga ccaaaaatct tctgaaatat aacaagagag tgactcgaat ttaaaaagct
     9421 agagttccac aattggaaat ctctagcttt tttgtgactg agaacttttt gtcccagcct
     9481 ctactttcta ctgactacta tcctgcatgc cctaagtcga gatagagaat atctcgctta
     9541 gtggcatact ctagcgcatg ttcaacagcc tcaaataaat ctgaagctag aaaccttttc
     9601 gtaaagacgg tttcgtcttt acgcttaaat ttcgcaacat aactatgttt agtcattttt
     9661 tctccttcta atattcatat tgtcctttaa caccactata gatccagtaa actgctttat
     9721 cataaacttg tttaaaggag atacctaatc gattggctac atcaagaatt gaaatttgct
     9781 tacattcctc tatattcata aaatatcatc attttgtcgt agtattcggc aatgatggaa
     9841 cagatgagga ttcttctaaa gttttaggag ttgccttatc tagatcatct aacccagatt
     9901 tccaaacctg tacttggttg accaataact taccaggtag tttcgaatag ttcaaattaa
     9961 ccgttctggt ttctgtttag tttgtctttg attggttggc attctttaaa tcagatacat
    10021 aagttacatt ataagagacc atggcaatgg cttgattcgt agtctgattg acaaagatat
    10081 ctgctttttc aaaatgataa tccaaaatat agtccttata cacttggttc atggcatcat
    10141 tttgacttgt caattcttga gaataggccg attcagtcat ataaggttga atacgtgtat
    10201 tattttcccc tagtttttct ttcgtatagt actgtgtcaa aaattctttt acagtatctg
    10261 atgataaaat acttgcttta tcttctgctt gtttgtcctc tacaagttta gctgcagcca
    10321 attcgatttc ttttcgactt tgtttggcag tagaatgttg accaatagaa ttagcagtaa
    10381 gttgtggtgt tgatgaggtg gatatactaa aaaatgagga ggaaattgat aatgacttca
    10441 cctagctaaa agttcaacga attagggaga cattaggtag cctcatatta ccttgattag
    10501 tttttgctat aacattgtca aatatgatga caaaaaaatc cgtccgcact tttttacgag
    10561 taggacgaat taaatatgtt atacaaacca tcagcttttt aacaattcta cataaggtag
    10621 ttgttaatgc aactaccttt tttctatgtt gattagaaca aatttgacat ggctacaact
    10681 gcgattatct gatatagagt attatataaa ctgattcctc ctacccctta tccacaattt
    10741 taatacggct actgccatcg tgcgacttga tgataactag ttgctgagca ataccttctt
    10801 tcatatcgtc cacgtggctg atgacaccga ccatgcgatt ttcaccgatt tgttctagga
    10861 cagagatagc cttagtgagg gcttccttat caagtgaacc gaaaccttcg tcgatgaaga
    10921 gtgcttcaac aacggcaccc ttgctggtat tttggacaac ttctgagagg gatagggcaa
    10981 tggccagtgc agcgataaag gtttcaccac cagacaagga tttaacggag cgttcactac
    11041 ctgtcagctg gtcatagacg ttgatatcca aaccgaagtg atcacgcgcc ctgcgtcctt
    11101 cctcacttag aacaaaggaa tagcggttat ccgttaatag tccgatgtag ttagcattgg
    11161 catagtccaa gatttgttgg aaatactgac ggataacgta gacctcaaga ttaagacgac
    11221 cagttagagc agtattttct cccttaacca ccttaaccaa atcactgagt tcttggtggg
    11281 ccttaaaggc ctcttggttg ctgtcttgaa gggttttagc cgcttggtag gtagccgtcg
    11341 catccttaag tcccttttcc atgacagaaa actgagcgag ctgcctatca tagatttcct
    11401 gacaattctg tactgcttgc gctagactat cgagatctgg ttgttcttga ttttggagaa
    11461 gctcttgccc cttacgaatc tgcgcctgta attcttgttt gagcgttgca taggtcgtta
    11521 atttggcctg aagcatagga atagcttgat tatttacctc aataagccag agttcgacct
    11581 gctctaagtc attggcgagg gctccttcag ccttgagact ttgctctaat tcagcagata
    11641 atcgcttaac atcttgattt accttatctt tagacttagt tatactctca atctgcccct
    11701 tgattccttt aatgtcggca tgaagttggt tgtaggcttc gctattttcc ttgacttgct
    11761 tattgtagag gttcagctcc tgatgagcaa gggaaatccg ttcttgatat acctcaacag
    11821 actcaagttc tggatgagct tcctgcaagt cctctaggcg ttcttgagct tggtcaagca
    11881 ctgccttggc ctcttgatag gttttagcca aatctgtcgc ttttttttga gccttaccta
    11941 gctcatcttg atatcggata taatctgtct cttccttatc ataacgtttt tgtaactctt
    12001 gataatactg ctcaaccttc aggagtaggg cttgcccacg gtcagtttca tagtctatcg
    12061 aaaaatcaaa atcaaaccgt cccttaacgt gctcttctaa ttcttgatag tgcttttcaa
    12121 gagttgcctt gactttagtc acttggtcaa gcaaatcctg acgtttagat gcaacttcac
    12181 tcaaggtagc ctgacgattt gataaagtag cgacttgctt ttctttttga gcttgaagct
    12241 tctccacctg atccatgaga tttttcaagg ccacttcatc agcctgtgct ccaccaacat
    12301 tagggtgttc cagagcacca caaaccatac aaggatgccc ctcctctaac tctgcctgca
    12361 gttggacaat catgagttga cggcgtgaaa ccaaagtcct tcttaactcc tcttccaatt
    12421 ctttgagaat ttcttgagct tgatcaatat caaaagataa cgtttgatga cgtttttcgg
    12481 tctttgtcaa ctcctgattc aagttctcta tctctttcag gtcctgagca agttgattct
    12541 ccacactgta gcccacaatc tggaagagtt tttcggcctc atgtaaactc tctaaactaa
    12601 gacgattagc ctccaagtca gacaaggact tgttaagcat ctcaacctct tttctagcct
    12661 gctgataggt ctcttccaac tgcttgtagt tagtcgttga acgtttgatt ttctcctgtt
    12721 cttgggcaag actctgggaa tagataatat cctctttcca agtttcaagc tcctcttctt
    12781 tttgaagaaa atcctcagat tgaattgcga gttcctcttt tttagcctta acatcctcaa
    12841 acgcctgttg cttttcactt aaggcttctt gagcaatttc aaggtcctgc tctaattgca
    12901 tcaactgttt ccgatactgc ttcaaggtcc gaatggtttc ctgcagacct tgagcaaact
    12961 gtaattcctc cagatgcact tttgcctctg cctgtccttg agccccctcc tcaatttcca
    13021 gacggtaacg ttccttggct tgctccaatt cttgaaaaat ctttgccaaa tcttgggcag
    13081 tttggaagct cttctgcagt tgtgccaaat cctcgtgggc agccttcaag atactttttt
    13141 gctccgtaag actttcttga cgctgagaca aaaactcttc aagacgtgcc aatttttcag
    13201 aggctggcgt tgacgccaag acagttaatt cttcctccga ccaaacctga ctggcaaagt
    13261 ggctatctat ctgagcctga cgcttatcca tatccttatt gctctgacga agacgctctt
    13321 ccaaactctt ttgaaaacgg tcaaagatac ctgtcccaaa gattttcttt aaaatttgag
    13381 tcttagtctt ggaatcttcc ttcaaaaaac ggctaaaatc attttgcggt aagaggataa
    13441 tctgtttgaa ctgctcagca ttgagcccca aaatctgctc aatctggtca ctcacttcct
    13501 tgatcttatc cccaagcttt tcaatttcct gaccaccaat cttatccaca atgactagag
    13561 aagccgtcgc cttttgcatg gtagtgcccc caccctgctt ggccctctct tgctggagaa
    13621 ctcggtcaat gcgataaagg tgattgcctt gttggaaata gaaagtcacc ttggtcaaat
    13681 catcctctgg accagcgaaa gttgaccgca tctcctcaac attacgatca ccactggtcg
    13741 tagcaaacaa ggctaccgtc atggcatcaa agagagtact cttaccagcc cctgtatccc
    13801 ctccaatcaa aaagagggga gcatggtcaa actgagtgaa attaataact tccttacgat
    13861 atggtccaaa attggtcaat tctaactgga ctggtctcat tgtcgactcc tctcaatctc
    13921 ctcaaaaaca ctttccacaa gggcagtctg tctctcagat aagacatcgc ccccagttac
    13981 tgtctggtaa aaatcaaata cgatttcctg gggcgactgc atttccaaat cttttaagtg
    14041 ctgatcaacg gtcaagtttt cttccctaac atcacccaga cgactgaaag taatttctac
    14101 aatgtctgtc ccataaatct cttccagtcg ggcacgcaca ttgataccct ctaattcctt
    14161 acgactagac agttgaatat caaaggcgaa ccaggctttt tgacaaggtt gattcttata
    14221 aaattcaggt gacatcaagg tttcaaaaga ttcctgtaaa gccacaatcg gccgtttaac
    14281 ctctagagta tggaaggtct gagacatatc accagacgca tccaattcaa gaatatagac
    14341 acccttttct tccttacgct tggcttcttt gacattaaag gcgactggac tgcctgaata
    14401 ttgcacgcgc ttggtaggac tagcaaaacg cgtatggata tgccctaagg caacataatc
    14461 gaaagacttg aaaaggtcac tggtcacatt ggtaagacca cctaccgtat tactggtttc
    14521 agacaacatc aattctcgaa gaccctgacc atcgctatca tccttcttag aaaccgcaaa
    14581 atgcgtcacc aagacatgag ctttgtcagg atcaaaagct tttttcatat cctcaagaat
    14641 gtaggtcaag gcatcaccaa tcccctgaat ttcctttccc tcatcatcct tatagtaaat
    14701 acgagcatca ataggatcga taaaaggcag cagaaaaatc tggcaattct ccaactcaat
    14761 gggctcaaaa gcctcctcca aacgtgtact taaatgaagg ccctgatgtt gaaagaagtc
    14821 acgcccaaaa tgtaaacgtt cagccccatc gtgattacca ctaatcgcat agacaggaat
    14881 ctgctcctcc agtaccaagc gggccaaggt cttattaaaa agcttaatcg catccacagg
    14941 gggcaccgca cggtcataga ggtccccaga aatgataacc ccatccactt tttcgctaat
    15001 agccaaatcc acaatttgtt gaaaagccca ctcctgctcc tccaacaaag accagccatt
    15061 gagggttcgt cctacatgcc aatctgacgt atgtaaaaac ttcatgacaa cctcctcatt
    15121 cattttgtct tacttctatt gtaccttatc aagctaaata ctgcttaaaa gtttcacagg
    15181 ctttgatagt tttcccgttt tttagctgta aagatcaaaa aatctctccc aagctatcct
    15241 gtactgaccc caaaaagtta gacaatttat gtaagcaaag gatttagctc tgtattgcac
    15301 aggattgagt ccttttagtt ttaccttaat gcatttgttg ttgtagtaat caatatagtc
    15361 tagattaccc tgcctcaatt ggttaagtaa tttaaatacc tctaaccaag aaaatcaata
    15421 ttatctattc ttttaattga cttttataga ttctaagcat tatcatatag gttggtacta
    15481 gtgcacatct tgtattttag gcaataatat ttactcactt ttcgttattg tcagtaccga
    15541 tcctttttaa atttttcacc atgaaaacct aaaaataatc cgaaccctaa gggctcctga
    15601 ctttttactt tattctaggc tttttttatc cgtagcttgt tagctgactt ggaactaggc
    15661 atgtagtatt tactatttcc ctacttgaga ttttttataa gtcacatgca ttattccatc
    15721 tgaacgaatg gtatgatttt tatttctttt agagaaacac cggtaatagc taattcctat
    15781 cttaaatcac ttgaaatata tttataatgt gttggagtgc taatcagtac cgcttgtaga
    15841 tttttggaag atactaacac actaatgatt taatctcctt taaaacatga aaagagaagc
    15901 ctccaaagct tctcttttat aattatcaaa taatgtacaa ctagattctt aataactacc
    15961 taatttagtg gttcaatcat gaagcttaat tgatagctat ctgctgagct aagcaagaat
    16021 tcgtcatgaa ctggagcacc ccatgtgtcg tcaccaccta cacccatttg agcagcaaga
    16081 actttaatcc atgtagcatc agattcttgc aactcatatt ggtgacgagc attttcaatt
    16141 tgttcagtac tgttacgcaa agcactgaat tcgaatgctt tattaagtgc ggtgaattta
    16201 agaccattat ggttatcatc agatactgtg aattcacgag taccatagtg attaccagat
    16261 tcttgtggca ttagatatgg agcaaatgtc ttttcaacag atgtttcata tcgaccaaga
    16321 taggcaccag gaagtttatc acggtagctt tcttctgcac cgtatccata atagctaagg
    16381 tttgtaaatt gtgaaccgat agcaaattct agaccaaatt cagggaagtt tggcaaacct
    16441 gctttaccat catagtttgc agtaacaaag attcgaccct tgtaatcaac ttgataagtt
    16501 accttaactt cgacatcaga caagcctggc aattcatgaa cataagtcac tttaacagag
    16561 tcgtcttcga tttgaatttg agtatctgta actttactat agtttccagc aaccttccag
    16621 cctgccattt cgaatggata tccagcacca cgatcgttgt cagtgtaagc acgagtgaag
    16681 ctaagtttag gacctttctc aatgaattca acaccattat acttagcaga tactaaagta
    16741 ttttgtgcac gtgaaagcaa gattgagaag ttttgtcctt gaataccgat gttgaagtcg
    16801 ccttcaacaa cattcaaagg tgctttaact ggtgtttcag tgctaatctt ttcaacaaca
    16861 tattgaccac gaacaatttc atgaccttta ggagcccatt cagttgcttc cctcagaaca
    16921 caagcaactt cgtaaatttg ttcagaattt gaagcctcga ctacaaagtt aactgggaat
    16981 gttgcttctt cgcctggttt aacatcaaag tgatattcac tttcactaac ttttctacca
    17041 tcttcgtaaa ctctagctag gaaagtataa gcagaaagat cttcgaagag attatcattc
    17101 ttgatagtta ctgatttttc atcaacagca atcttaatat tagagtaaag atgtttaact
    17161 gtttgaagtt ttggagttag ggtacgatct gcaaagacga taccatttcc acaaaattcg
    17221 tagtcagaag gtctatcatg ccagtcacca ccatatgata ggaattcgct accatttgga
    17281 agtgttttgt aaatagcttg gtcaatgaag tcccaaataa atccaccttg gtattctgga
    17341 tatttctcta agtcagtgta gagttgcaat ccaccaccag agttacccat tgtgtgcatg
    17401 tattcacatg aaatataagg tttttgaggt ttgttagtta ggttacctga agcaaagtgt
    17461 ttatcactaa cgcttgaaag atcaactagt ttaccagttg tgaggtattc ttcgatatca
    17521 gctggtttcg catacatacg actttcgatg tctgtaatgt aatcaaactc acgacaccat
    17581 gcaacacctt catagtgaac tggacgagta ttgtcaacac tacggaagta atcagccatg
    17641 tcagcaatat ctttaccagc atatgattca ttaccacaag acc
//
