LOCUS       c00039_JAIPUO0..       12576 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIPUO010000045.1 Lacticaseibacillus rhamnosus strain cek-R1
            PairedContig_56, whole genome shotgun sequence.
ACCESSION   JAIPUO010000045
VERSION     JAIPUO010000045
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 11:38:19
            Original ID  :: JAIPUO010000045.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 45825
            Orig. end    :: 58401
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12576
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[55825:57883]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Flavoprotein,
                     Semialdhyde_dh]) and gallic_acid)"
                     /neighbourhood="10000"
                     /product="gallic_acid_met"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..12058
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Flavoprotein,
                     Semialdhyde_dh]) and gallic_acid)"
                     /neighbourhood="10000"
                     /product="gallic_acid_met"
                     /protocluster_number="1"
     cand_cluster    1..12576
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [Flavoprotein,
                     Semialdhyde_dh]) and gallic_acid)"
                     /kind="single"
                     /product="gallic_acid_met"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12576
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="gallic_acid_met"
                     /region_number="1"
                     /rules="(minimum(1, [Flavoprotein, Semialdhyde_dh]) and
                     gallic_acid)"
                     /tool="gutsmash"
     CDS             88..351
                     /locus_tag="ctg39_46"
                     /transl_table=11
                     /translation="MKKKPSVLDQLPELIADPETTGPELEILKHAEIRRQRGNNEEGIA
                     FEIRTKLQPLAIGQKLSPKVVDFLTAISARYLGMGNRGNIIF"
     CDS             complement(444..1238)
                     /locus_tag="ctg39_47"
                     /transl_table=11
                     /translation="MSQSPAKFERLNEIIQILRETPEISIAQLSKQMFTSKSTLRRDLI
                     ELENSNIIRRHYGTVQLLQGNNLEFTYEKRRNENARLKRVISRQIAAKIPSKAAFFIDG
                     SSTFFSLPELLHEQVGLHVITNNVNMGMQFNSLNNVETIILGGKMAPRTASTLGATTIN
                     EIQSFRPDFALLSIGSIDADGIYVADPEQAAVKEAMIDAAKCVILGIDSTKFNQSDYIR
                     ITNMDQISEIITDTQPAPEYGNLFDDHHIQLTYPKAHHHLAD"
     CDS             1444..1923
                     /locus_tag="ctg39_48"
                     /transl_table=11
                     /translation="MDYSTIIHKQLIFLNENQPDRQHLFRAVAEKLQAAGYVKKTYEAA
                     LNRREDEFPTGIVFPEISVMLPHADPEHVIKPFMAIVKNAQPVRVLQMGYNEPEDATAM
                     FFLGITDSSQQVGLLQIFMDLLQNQDFVAKFKATNDRDAMYQLFVDTFEAQTTGK"
     CDS             1945..2265
                     /locus_tag="ctg39_49"
                     /transl_table=11
                     /translation="MAKIVVACGSGVASSEATASRIKDFFESHNVKGVSVDATDFKQLP
                     EVLHNYDVYVWIAKPNQQLEELAKENNIAVVNGMPIFMNMNPEKSYKQIIQALKNMQAA
                     GK"
     CDS             2338..3906
                     /locus_tag="ctg39_50"
                     /transl_table=11
                     /translation="VTILKDVVNYILNLGGPVFVPLIMLILGLVAGLKFKKSIVAALTL
                     GIAFSGMTLVVNYMMDAISPAAKAMSKLFHLSLNAIDAGWTGVAAITWSYKSAFLFFPL
                     LLAINFVMLTFNWTKTLNVDMWNVWNKIFTYVVVLYFTHNAFFGFLVAGIQIVFELKAG
                     DMWHRHIEDLTGMPGVTVPHFITLFAVILQPLNKLLDFIPIMNKPFDADALQKRIGVWG
                     DNTVMGALIGVLLGFGAGYSVSGSLNLAIKAATAMTLFPMISKLFMTALSPIADAMSGF
                     MQKHFKGREVYIGLDWPILAGRNELWVTVIILVPIMLVFAMILPHNTVLPFAGIINLSF
                     VNAALLLTGANLLRMITLGIITTPIFLYGATYFAPVITNLAKSTGTVKVQAGQQLSWST
                     FEGPDFRLFFAQAFNGKWWAIALAVLWTLGFIWLYRDQNKIKLPSQRYGTLTTPAVATT
                     SSTSTADSADADVDLDNLSGLDFSDAKASNESKQSAAKNDDDLDDLDGLDFSQTSHKKK
                     GDQGE"
     CDS             3899..4135
                     /locus_tag="ctg39_51"
                     /transl_table=11
                     /translation="VSKTLASFLVFIDTIGVSIALLGGSVGLCLLMGLVTIVLYSKVNP
                     VLFGDYDRKRRERINQRRKELLAQRVKNGGFSK"
     CDS             4132..4860
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldolase_II"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_52"
                     /sec_met_domain="Aldolase_II (E-value: 6.4e-31, bitscore:
                     99.6, seeds: 389, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQYVFENERKDLAEVAREMFVRKNTNVAGGNISVRITADKDID
                     YGSIHIKAGKDYLIMTPTMISEAWYAKLQPTQILVVDLETGKQIDGVGRLTREINMHEE
                     AYRANDKIRCVYHSHAEESMFWATAGLDMPNVTEVTEEVGPIRVLPYAPACSKELADTV
                     YNGLKAVGDAAKEHIFLLNSHGVLITSEDLHHATEILETVEWNAKIAYQQTVFMKLGLL
                     DSYQSCGKASDGMLKEQVQA"
     CDS             complement(5092..6474)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 142.5; E-value: 5.1e-44)"
                     /gene_kind="transport"
                     /locus_tag="ctg39_53"
                     /sec_met_domain="MFS_1 (E-value: 4.9e-44, bitscore: 142.5,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRKVTPKLYLSILATGLMAFCGVLIETAMNVTFPTLMRQFNVDT
                     GTIQWLTTGYLLIVAIIVPISGFLKRRFTTKQLFLTASAFFILGLALCSVANSFAILLV
                     GRLIQGCGTGIALPLMFNIILEQAPLEKIGFLMGIGTLVTAIAPALGPTYGGVLVDINW
                     HLIFIFLLFVMIAALIMGLFSIQQVSETVHLHLDFLAWLFIAIFFATAILGLNSIEHQP
                     GRALIFAVIAILSLGAYTMRSLHVKEPLINLRLFKNLPFDLHMTTFLIIQIVNVGFAFV
                     LPNYLQLVNHTSSLTAGLLLLPGAALGACMAPMSGKLYDKLGPGRPIFIGLCLQLIGIV
                     WLLLEALTAAPVIVLIGYAFIMLGTGFSMGNIMTSGQAQLHQEQTTDGNAIFNTLQQFA
                     GALGTAVVSLIMALAQAGSTSAHNTAIGSQHAFGFLLLLTLVGDVAIFFGLRRRRGETT
                     GK"
     CDS             6607..7044
                     /locus_tag="ctg39_54"
                     /transl_table=11
                     /translation="VTVSLGILVKKLNNDLQRYADREAKQLGLTQVQMSIIDFLARQGT
                     KRPLYQTDVEHEFNIQKSSATALLQLMERKELIVRVPSKQDGRYKAIQLTEKSQKVAAY
                     IRHFFDQNDAFLRNALGEDAEVVVNALEKLQTTMADKLADH"
     CDS             complement(7107..7538)
                     /locus_tag="ctg39_55"
                     /transl_table=11
                     /translation="MSDYPVPTYTTTVTQSDVTLIATVTVIGRDLLITITGGDHPHIGD
                     VLTLTKDQPIQTIRYPSHDNRFHKDDLLALPSAKALQPLLPGSCTILAGLHIDHISKVQ
                     IQAALDLSHKLAPELMTWLKHQTFATSRPHYYGPDESPA"
     CDS             7568..8467
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     61.9; E-value: 1.4e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg39_56"
                     /sec_met_domain="LysR_substrate (E-value: 1.4e-32,
                     bitscore: 104.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.3e-19, bitscore: 61.9,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNFEDLKIFVALYELKSFSKAAVVLHLSQSALSKRIQHIEAILGS
                     KLVDTSNHRRMLVTEAGERFFFHASKILHQVELMNTDLNSLKSLSNGVLTIGAVPILGQ
                     FGISRLINDFAAQFPKLALHVVEQEGISILKQLLTGDLDMALLRDTQAEVLSTREYVKL
                     DLAKDELQVILAKTNPLAKRPSLSAKDLAATTIVSLLSGSGVFEPMQAFFADRHIAPKI
                     IFSSPHIETLLGMVEGSRHVTFLFRQSYQPFANSNFVAKSLTPNICSHLQLVYRRTSNP
                     AILKFADYLSQQVTAEKG"
     CDS             complement(8613..10004)
                     /locus_tag="ctg39_57"
                     /transl_table=11
                     /translation="MKKVLNKQSIGFLIGIAVGLIVYLAPLSGINEKAQMDLALSLMTV
                     VWWAFQIAQPAYIGGIYLMLLILTNVATPTQVFAGSWTKSIMWLVMGAYLIAGAVRESG
                     LGERIAYAFIIKFVRSWTGIIVSIFALTFILALLIPHPWPRAFLIMSVMDVVATSAKMP
                     QQDRAKLGLAVFAASCPLSGAFLTGDTSLNPLAIADSGKSVNFVQYFIYMGVPMIIAAI
                     ITMLLFLFLFKPTKKVTIDLDVLKAKQADQGAMTHKEIRVIVWLVIAIGLWLTSGITGI
                     DVGWLTLIVALLMSLPVIGEVLTAKSWSGVPVNVLVFLTSAIAIGQVGDFTGMNKWIAQ
                     TILPSALPHNLYLLALVITVFAMIIHMFMGSVIAVMGITIPAIIAATSSLGVNPLAISL
                     IVFSVVNLHYILPFHNLAILVGSDPETGGGYTQKDVMKLGIPLTAVMFIVALVEVFWFQ
                     LTGLL"
     CDS             complement(10001..10573)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     gallic_acid_met: Flavoprotein"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_58"
                     /sec_met_domain="Flavoprotein (E-value: 1.8e-30, bitscore:
                     97.7, seeds: 91, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKRIIVGITGASGTIYAVNLLQHLHRLPDVEVHLVMSAWAKQNLS
                     LETDMKQSELEALADYVYPVQNQGATIASGSFLTDAMVIVPASMKTIAGIAMGFDDNLI
                     GRAADVTIKEQRQLIIVPRETPLSPIHLDNLAKLAHIGVQIIPPIPAFYQHPQTIQDLI
                     EHHTMKLLDALHIKTETASRWNGASLR"
     CDS             complement(10583..12058)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     gallic_acid_met: gallic_acid"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_59"
                     /sec_met_domain="gallic_acid (E-value: 1.4e-228, bitscore:
                     750.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTASPWDLRKVLDELKQDPQQYHETEVQVDPDAELAGVYRYIGAG
                     GTVERPTQEGPAMMFNNVVGFPTTRVLIGLMASRKRVGKMFHQDYHTLGRFLNKAVLNP
                     IQPVTVEESAAPAHEVVAKASDPDFDIRKLVAAPTNTPQDAGPYITCGVVLGSNMAKTM
                     TDVTIHRMVLEDKDTLGIYIMPGGHHIGHFAEEYEKANKPMPVTINIGLDPAITIGATF
                     EPPTTPLGYDELGVAGAIRQEPVQLVQAVTVNEKAIARSEFTLEGYIMPNTRIQEDINT
                     HTGKAMPEFPGYDGDANPALQVIKVTAVTHRRDHPIMQSVIGPSEEHVSMAGIPTEASI
                     LQLVDRAIPGKVKNVYNPPAGGGKLMTIMQIHKDNPADEGIQRQAALLAFSAFKELKTV
                     WLVDDDVDIFDMNDVVWTMNTRFQGDQDIMVLPGMRNHPLDPSERPQYDPKSIRVRGMS
                     SKTVIDGTVPFDMRDQFKRAAFKKVSDWQKYLK"
ORIGIN
        1 caaaaattaa cttagtattg ttcaacaaga caatagcagg gttgcacggt ccatagcaat
       61 gtcgctaacc gtttggaggg accttttatg aaaaagaaac catcagtact ggatcaatta
      121 ccggaactta tcgcagatcc cgagacaacc ggacctgaat tagaaatttt gaaacatgca
      181 gaaattcgac gtcaaagagg caataatgaa gaaggaatag cctttgaaat tagaacaaag
      241 cttcaacctt tagcaattgg acaaaaattg tcgcctaaag tagtggattt tctgactgca
      301 atttcagcgc gatacctagg gatggggaac cgcgggaaca tcatctttta acgataacaa
      361 atagacgtta gtaagcccaa gttggtttta ctagcgtcta ttttgtttac agctatcagg
      421 tatgaataag acagcgagtt gtttcagtca gccaaatgat gatgcgcttt cggataagtg
      481 agttgaatat gatgatcatc aaacaaattt ccgtattctg gcgcgggttg cgtatcagtt
      541 ataatctcac tgatttgatc catatttgtg atacgaatgt agtcactttg attgaatttg
      601 gttgaatcga tgccaagaat gacgcatttt gcagcatcta tcatggcttc tttaacggct
      661 gcttgctctg ggtcagctac atagataccg tcagcatcga tcgagcctat tgaaagcagg
      721 gcaaagtcag gacgaaaact ttgaatttcg tttatcgtcg ttgcgcccaa agttgaagca
      781 gttcttgggg ccattttgcc accaagaata atcgtttcga cattgtttaa tgaattaaat
      841 tgcatcccca tgtttacgtt attggtaatg acgtgcaagc cgacctgttc gtgtagaagc
      901 tcgggcagac tgaaaaaggt agaactacca tcgataaaga aagctgcttt gctgggaatc
      961 ttcgcggcaa tttggcgact aatgacgcgt ttaagacgtg cgttttcgtt acgtcttttt
     1021 tcatacgtaa attccagatt gtttccttgc agtaactgca ccgtaccgta gtgccgccgg
     1081 atgatattgc tgttttcaag ctcgataagg tcacgtctca gagtggactt actggtgaac
     1141 atttgcttgc ttagttgcgc aatactgatc tctggtgttt cgcgtagaat ctgaatgatt
     1201 tcattcagac gctcgaattt tgctggactt tgtgacatta taaacgctcc ctcaattgaa
     1261 ttttattgaa ccgatttgaa caggatgagc ggcattttgt gaacacttct caaccttgat
     1321 gaaaccttac aaatactata gacacgcgaa tgaaagcgct ttagcattga aaatgaaata
     1381 agttaaaaga ttcaaaaagg ttcaaaactt ttggtctaaa tattcgattg aggtgagcta
     1441 gttatggatt atagcacaat tattcacaaa cagctgattt tcttaaatga aaatcagcca
     1501 gaccgtcagc atttatttcg agcggttgca gagaagcttc aagctgccgg atatgtaaag
     1561 aaaacctacg aggcagcttt gaatcgccgc gaagacgaat ttccaaccgg cattgtcttt
     1621 cctgagatat ccgtcatgtt gccgcatgct gatcctgagc atgtcattaa accgtttatg
     1681 gcgattgtaa agaacgctca gccggttcgg gtgctgcaga tgggctacaa cgagccggaa
     1741 gatgcgactg ccatgttttt cttgggtatt acagattcga gtcagcaggt aggcctctta
     1801 cagattttca tggatttact acaaaatcag gattttgtcg ccaagtttaa agcgacaaat
     1861 gaccgtgatg cgatgtatca actttttgtc gatacatttg aagcacaaac cacagggaaa
     1921 taattaaaaa ggagcgtaaa gatcatggca aaaattgttg ttgcatgtgg atcaggcgtt
     1981 gcatcaagtg aagcaactgc cagccgaatt aaggattttt tcgaaagtca caatgttaaa
     2041 ggcgtatcgg ttgatgctac tgattttaag cagttaccgg aagttctgca taattacgat
     2101 gtctatgttt ggattgcaaa accgaatcaa caattagagg aactagccaa ggaaaataat
     2161 atcgcggttg taaatggtat gccaattttt atgaatatga atccggaaaa gtcatataaa
     2221 caaattattc aggcgctaaa aaacatgcag gctgccggaa agtagttggg taaacgggga
     2281 cgctagatgt gtcagcgtgt ggcggctcgt gctcactttt tgaggaggta gaaaactgtg
     2341 acgatcttaa aagatgtcgt taattatatt ttgaatcttg ggggaccggt gtttgttccg
     2401 ttaatcatgc tgattctagg tctggttgcc gggttgaagt ttaaaaaatc gattgtggca
     2461 gcgttgactt tagggattgc cttttcgggg atgaccttgg ttgttaacta catgatggat
     2521 gcaatttcac cggctgccaa agctatgtca aagttgttcc acctaagttt aaacgcgatt
     2581 gatgccggct ggaccggtgt tgcggccatc acatggtcat ataaatcggc atttctgttt
     2641 ttcccgttat tattagcgat taactttgtg atgttgacgt ttaattggac gaaaacatta
     2701 aacgtggata tgtggaacgt ttggaacaag attttcactt atgtcgtggt gctttacttc
     2761 acgcataatg ctttctttgg attcttggtt gcagggattc agattgtgtt tgagctcaag
     2821 gcaggtgata tgtggcatcg acatattgag gatctgacag gtatgcctgg ggtaacagtg
     2881 ccgcatttta ttactttgtt tgcggtgatt cttcaaccgt taaataagtt acttgatttc
     2941 atcccgatta tgaataaacc gtttgacgcg gatgccttac aaaaacgtat cggtgtttgg
     3001 ggtgacaaca cggtgatggg tgcgttgatc ggggtactgt taggatttgg cgctggttat
     3061 tccgtctccg gttcattgaa tctggcaatc aaagccgcga ctgccatgac gttgttcccg
     3121 atgatttcta aactgtttat gacggcactg tcaccgattg ccgatgcgat gagtggcttt
     3181 atgcagaaac acttcaaggg tcgtgaagtt tatatcggac ttgattggcc aatacttgct
     3241 ggccggaacg aattatgggt gactgttatt atcttggttc caatcatgct cgtcttcgca
     3301 atgattttgc cgcataatac ggttttgcct tttgccggca ttattaacct atcgtttgtg
     3361 aatgctgcgc tgttgctgac aggggcaaac ttattgcgaa tgatcacctt gggcattatc
     3421 acaacaccga ttttcctcta tggtgcgact tattttgcgc cggtcattac gaacctggcg
     3481 aagtcaaccg gaaccgtcaa agttcaagca ggacaacagc tttcgtggtc aacttttgag
     3541 ggacccgatt tccgactctt ctttgctcaa gcatttaatg gcaagtggtg ggcgattgct
     3601 ttagcagttt tatggacgtt ggggttcatt tggctatacc gtgatcagaa taagatcaaa
     3661 ttaccaagcc aacgttacgg caccttgacg acgcctgctg tagcaacgac aagttcaacg
     3721 tcaacagcag atagcgctga tgcagatgtc gatttagata atcttagcgg gttggacttc
     3781 agcgatgcaa aggcttcaaa tgaaagcaaa cagtcagctg ctaaaaatga tgacgattta
     3841 gacgatcttg acgggttgga ttttagtcag acaagtcata agaagaaggg tgatcaaggt
     3901 gagtaagacc ttagcatctt ttctggtttt cattgatacc atcggcgttt caattgcgtt
     3961 gcttggcggc agtgttgggc tttgcctcct gatgggcctc gttaccatcg tattgtatag
     4021 caaagttaat cccgttttgt tcggtgatta tgaccgcaag cgacgcgaac gaattaacca
     4081 acgtcgtaaa gagttgttgg ctcaacgtgt aaaaaatgga ggattttcaa aatgactgaa
     4141 cagtatgtat ttgaaaatga gcgtaaggat ttggcagaag tagcgcgcga aatgtttgtg
     4201 cgaaagaata cgaatgtcgc tggtggcaat atcagcgttc gtattaccgc ggataaagat
     4261 attgattatg gcagcattca tattaaggcc ggcaaagatt atcttattat gacacctacc
     4321 atgatatcag aagcttggta tgcgaagtta caaccgaccc aaattctggt ggttgatctt
     4381 gagactggca aacagattga tggggttggc cgtttgaccc gggaaatcaa tatgcatgaa
     4441 gaggcttatc gcgccaatga taagatccgt tgcgtttacc attcacatgc cgaagaatca
     4501 atgttttggg caactgctgg ccttgatatg ccaaatgtta ccgaggtcac tgaagaagtc
     4561 ggaccgattc gcgtattacc ctatgcaccg gcttgctcaa aagaacttgc cgacactgtc
     4621 tataatgggc tcaaagcggt gggcgatgct gcaaaggaac acattttctt gttaaatagc
     4681 cacggcgttt tgattacgtc ggaagatttg catcatgcaa ccgagattct tgagacggtt
     4741 gagtggaatg caaaaattgc ctatcagcaa acggtcttca tgaagctggg gctgctcgat
     4801 agttatcagt cttgcggtaa agcgagtgat gggatgttga aagaacaggt acaagcctga
     4861 agctaacaac ttgttggcat accatgcgct tacgataact gcttgcgcta agggattgca
     4921 aaagaactga gcagaactta aaaatcaaag tttcggtatg taagcgtttt gtcaaaaaac
     4981 tcttgttatg tggtaatccc catcatttat gccaacctaa aatgcccaca aacattgtgc
     5041 ttgtgggcat ttttcgttgc gttctttttg tgaaagcgtt aaattttttg cttatttacc
     5101 tgtggtttca ccacgacgtc gccgcaaccc aaagaaaatc gcgacatcac caacgagggt
     5161 taatagcagg aggaaaccaa acgcatgttg cgaaccgatg gcagtgttgt gagcagaggt
     5221 tgaaccggct tgagccagcg ccatgatgag tgagacgacc gcagtgccaa gtgcaccggc
     5281 gaattgttgt agggtgttga agatggcatt gccgtcagtg gtttgttctt ggtgtaactg
     5341 agcttgtccg cttgtcataa tgttgcccat tgaaaaaccg gtacctagca tgatgaaggc
     5401 atagccgatc aagacgatga ccggggctgc ggttaaggct tcaaggagta gccagacaat
     5461 tccgatgagc tgtaagcata gtccgataaa gatagggcgt ccaggaccta atttatcgta
     5521 tagtttacca ctcatgggtg ccatgcatgc gcccagtgcc gccccaggta atagaagtag
     5581 gccggcggtt agggagcttg tgtggttaac gagttgcaag tagttgggta agacaaaggc
     5641 aaacccgaca ttgacgattt gaatgatgag gaaggtcgtc atgtgcagat caaacggaag
     5701 atttttgaat aaccgtaaat taattagtgg ttctttaaca tgtagtgagc gcatggtgta
     5761 ggcgccgagg cttaaaattg caatgacggc aaagatcaag gcgcgtccgg gttggtgctc
     5821 gatgctatta agaccaagaa tcgcggtcgc aaagaaaatc gcaatgaata accaagctaa
     5881 aaagtcgagg tgaagatgga ccgtttcaga gacttgctgg atggaaaata gccccataat
     5941 caaagcggca atcatgacga atagcaggaa aataaagatc agatgccagt taatgtcaac
     6001 cagcacgcca ccataagtcg ggcctaaagc cggcgcaatg gcggtgacca acgtcccgat
     6061 gcccatgaga aaaccaattt tttctaacgg cgcctgttcc aaaatgatgt taaacattaa
     6121 ggggagtgca atccccgtcc cgcagccttg gattagccgt cccacgagca agattgcaaa
     6181 actgtttgca acgctgcaca gtgctaaccc aaggatgaag aaggcactgg cggtaagaaa
     6241 aagctgttta gtcgtgaagc gtcgttttaa gaacccggaa atcgggacga tgattgcaac
     6301 gatcaacaaa tagccggttg tcagccattg aatggttccc gtatcgacat taaactgccg
     6361 cattaaggtc ggaaaagtga cattcatggc agtttcaatg agtaccccgc aaaacgccat
     6421 cagaccagtg gcgagaatcg aaaggtataa tttaggtgtt acttttcttg tcataaagac
     6481 ctccatcgtg tatagttcta tatcgaacta tagctactat agcggtctta ttttctgaaa
     6541 tcaaggctta attttaatgt aaacgctgac ctgagatttc attgaaaccg aaaggggata
     6601 gacatcgtga cagtatcgct gggtattttg gttaaaaaat taaacaatga cctgcaacgt
     6661 tatgctgatc gtgaagctaa gcaattgggt ctaacacagg tgcaaatgag catcatcgat
     6721 tttttggcac ggcaaggcac caagcggccg ttgtatcaga cggatgttga acatgaattc
     6781 aacatccaga aatcttcagc aacggcactg ttacaactga tggagcgcaa ggaattgatt
     6841 gttcgtgtgc cctccaagca agatgggcga tataaagcga ttcagctaac ggaaaaatcc
     6901 caaaaggtag cggcatatat tcggcatttc tttgaccaaa atgatgcttt tttgcgcaac
     6961 gctttgggag aagatgcgga agtagtcgtc aatgcgcttg aaaaactgca aacaacgatg
     7021 gcggataaat tagcagatca ttgagggaac atctttgaag acaccaacta acggccatta
     7081 acgaattccc ggatctggtt gagcgattag gcaggtgatt catcgggacc gtaatagtgt
     7141 ggtcttgacg ttgcaaatgt ttgatgtttt agccaagtca ttaactcagg cgctagttta
     7201 tggctgagat ctaatgcagc ctggatttgt actttgctga tgtgatcgat gtgcaaccca
     7261 gctaaaatgg tgcagcttcc gggcagtaat ggttgcagcg ctttggcact tggaagcgca
     7321 agtaaatcat ctttatgaaa tctgttatca tgactggggt agcggattgt ttgaatgggt
     7381 tgatctttgg ttaacgtgag aacatcgcca atatgcgggt ggtcgccgcc agtaatggta
     7441 ataagtagat cacgtccgat cacagtaacg gtggcgatga gggtgacgtc agactgtgtc
     7501 acggttgtcg tgtaagtcgg gacagggtag tcagacattt tatagcttcc tttcggtggt
     7561 gaataagttg aattttgagg atttaaaaat atttgtagca ctgtatgagc ttaagagttt
     7621 ttccaaagca gcggtggttt tacatcttag tcaatcagcc ttgtctaagc gtattcagca
     7681 tattgaggct attctgggaa gtaagttggt ggatactagc aatcatcgcc gcatgcttgt
     7741 cacggaggct ggtgaacggt ttttctttca cgccagtaag atcttgcacc aagtcgagct
     7801 catgaacacg gatttaaata gtttgaagtc cttgagcaac ggtgttttga cgattggtgc
     7861 cgttccgatt cttggtcagt ttggcatcag tcgattaata aacgattttg ccgctcaatt
     7921 tccgaagctg gcactgcatg tggtcgaaca ggaaggcatt agcatcctca agcagctttt
     7981 gactggtgat ttagatatgg cattgctacg tgatacacaa gcagaggtcc tatcaacgcg
     8041 ggaatatgtc aaacttgatc tggctaaaga tgagttgcaa gttattctcg ctaagactaa
     8101 tccattagcg aaacgtccat cgctgtctgc aaaagattta gccgccacaa cgattgtcag
     8161 cttgctaagc ggctctggtg tctttgagcc gatgcaggcg ttctttgcgg atcgtcatat
     8221 cgcacccaaa atcatcttta gcagtccgca tatcgagaca cttttgggga tggtcgaagg
     8281 cagccgccac gttacctttt tgttccgtca atcttaccag ccgtttgcca attcgaactt
     8341 tgttgctaag tcattgacgc cgaatatttg tagtcatttg caactggttt atcgacgcac
     8401 tagcaatccg gcaattctta aatttgctga ctacttgagc cagcaagtta ccgccgaaaa
     8461 aggttaatgg taaccgtgat tgtagaatcc caagacgata tttcgactgt tgtgtagcag
     8521 taaggatttt aacgatacag cagtagcccc taaagaaaaa tcatttagga gctactttgc
     8581 attgatattg acttttaaca agggtaccgc tgttataaaa gtccagtcag ctggaaccaa
     8641 aagacttcta ccagcgcaac aataaacatg acggcagtta gcggaatacc taacttcatg
     8701 acatcttttt gcgtataacc accgccagtt tctggatcgg aaccgacaag gatagccagg
     8761 ttatgaaacg gcaagatgta gtgcaaatta accactgaaa agacgattaa tgaaattgcc
     8821 aacggattaa ccccaagtga cgaggttgcc gcgataatgg cagggattgt aatacccatg
     8881 acggcaataa ccgaacccat gaacatgtga atgatcatcg caaaaacggt aatgaccagt
     8941 gccagtaagt agagattatg tggtaaggct gaaggcagga tcgtttgggc aatccattta
     9001 ttcatgcccg taaaatcacc cacttggcca attgcaattg ccgaagtcag gaagaccaaa
     9061 acgttgacgg gaacacctga ccatgatttc gccgtcaaga cctcaccgat aaccggcaga
     9121 ctcatcagca aggcgacaat caaagttaac cagccaacgt caataccagt gatgccactg
     9181 gttaaccata aaccgatggc aatgacaagc cagacgatca ctcgaatttc tttatgcgtc
     9241 attgcccctt gatcggcctg cttggctttc agaacatcaa ggtcaatcgt gacttttttg
     9301 gttggtttga agaggaaaag aaagagcagc atcgtgatga tcgcggcaat gatcatcgga
     9361 acccccatgt aaataaaata ttggacaaag ttgacgcttt tgccagaatc ggcaattgct
     9421 aaggggttga gcgatgtatc cccggttaga aaagcaccgg aaagaggaca ggaagcggca
     9481 aaaacggcta gtccaagttt agcccgatcc tgttgtggca ttttggcgct ggttgccacc
     9541 acatccatca cggacatgat caagaaggca cggggccagg gatgcggaat cagtaaagca
     9601 aggatgaagg ttaaggcaaa gattgagacg ataataccgg tccaactgcg aacaaatttg
     9661 ataatgaaag cataggcaat acgttcacct aggccagatt cgcggacagc accggcaatt
     9721 aaataagcgc ccatcactaa ccacataatt gacttggtcc acgatcccgc aaatacctgt
     9781 gtcggggttg caacattcgt caagatcagc agcatcagat aaataccacc aatataagcc
     9841 ggctgtgcaa tctggaatgc ccaccaaaca acggtcatta aactcaaagc aagatccatt
     9901 tgcgcttttt cattgatgcc gctcagtggg gccaggtaaa caatgaggcc caccgcaatg
     9961 ccgatgagaa aaccgatact ctgtttattg agaacttttt tcatcttaac gacgctccat
    10021 tccagcgact agcggtttcg gttttaatat gcaaggcgtc taatagtttc atggtgtgat
    10081 gctcaattaa atcctggatg gtttggggat gctgatagaa agctggaata ggcggaatga
    10141 tttgaacgcc aatgtgggct agtttagcga ggttatccag atgaattgga ctaagcggtg
    10201 tttcccgcgg cacaataatc aattgccgct gttctttaat cgtgacatcg gctgctcgtc
    10261 caatgagatt atcatcaaag cccatcgcaa tgcccgcaat ggttttcatg cttgccggaa
    10321 caatgaccat tgcatcggtt aaaaaactgc cgcttgcaat ggttgcccct tggttttgaa
    10381 caggataaac ataatccgcc aaagcttcga gttcgctttg tttcatgtcg gtctcaagtg
    10441 acaggttttg ctttgcccaa gcactcatca ccaaatgaac ttcgacatca ggcaggcgat
    10501 gtaaatgctg gagcaggtta acagcgtaaa tagttccgga tgccccggta atccctacga
    10561 taatacgttt caattcaatc acctatttca aatatttttg ccagtcggaa acttttttaa
    10621 aggctgctcg tttgaattga tcgcgcatat caaatggtac ggtaccatca atgaccgtct
    10681 tcgaactcat tccgcgtacc cgaatagact tgggatcata ttgcggtcgt tctgacggat
    10741 caagcggatg gttgcgcatg ccaggtaata ccatgatgtc ctgatcacct tgaaaacgcg
    10801 tgttcattgt ccagacgaca tcattcatgt caaaaatatc gacatcatca tcgaccagcc
    10861 aaacagtttt tagttctttg aatgccgaaa aagcgagtaa tgcagcttga cgttgaatcc
    10921 cttcatcagc tggattatct ttgtgaattt gcatgatggt catgagtttg ccgccaccag
    10981 ctgggggatt gtacacattc ttgaccttgc cggggatggc acgatcaaca agttgtaaaa
    11041 tgctggcttc ggttggaatg ccggccatgg agacatgttc ttcactaggt ccgatgacac
    11101 tttgcataat gggatgatcg cgccgatggg ttacagccgt cactttaatc acttgcaaag
    11161 ccggattggc atcaccgtca tagccgggaa actctggcat ggctttgccg gtatgggtat
    11221 tgatatcttc ttggatacgc gtgttaggca tgatatagcc ttccagtgta aattctgaac
    11281 gcgcaatggc tttttcattg acggtcacag cctgaaccag ttgcacgggt tcttggcgaa
    11341 tggctccggc aactcctagt tcatcgtagc caagcggcgt ggtaggcggt tcaaaagtgg
    11401 caccaatggt aatggccgga tccaagccaa tgttgatggt caccggcatc ggcttattgg
    11461 ctttttcata ttcttcagca aaatgaccaa tgtggtgacc accgggcatg atataaatac
    11521 caagcgtatc cttatcttcc aaaaccatgc gatgaatcgt cacatcagtc attgttttgg
    11581 ccatattgga acccaaaact acgccgcatg tgatgtatgg gccggcatct tgtggcgtat
    11641 tggttggtgc tgcaacgagt tttctaatgt caaagtccgg gtcactagcc ttggcaacga
    11701 cttcatgcgc aggcgctgct gattcttcga ctgtaacggg ttgaatagga tttaaaaccg
    11761 ctttgttcaa gaatcgacca agtgtgtgat agtcttggtg aaacatcttg ccaacccgct
    11821 tgcgactggc cattaaaccg atcaaaaccc ttgtcgttgg gaagccgaca acgttgttaa
    11881 acatcattgc cggaccttcc tgtgtcggac gttcgaccgt cccaccggca ccgatgtaac
    11941 gataaacgcc agcaagctct gcatcgggat cgacttgcac ctctgtttca tgatattgct
    12001 gcggatcctg ttttagttca tccaatactt ttcttaagtc ccaaggtgat gctgtcatat
    12061 taatcactcc taaaggccgg aacagcgaac cagccgaatt gatttcaaaa tctaggctag
    12121 tctgggttgg aaaccttttc aattcgagtt ttgaatgctg ttatgcctga atggaataag
    12181 aaaaggacaa tgacattttt taatagttgt gatcgttaat gacagctgac ttgtaaatag
    12241 tcaatatatg taactcgagg ctggtcaaaa tgaatgagtt gacaataggg aaaaactaaa
    12301 agccggcttg atatatttcg gctctctcct aaaaagaaaa ataaaacccg catagatagc
    12361 catgcaggtt tgcaaacagt tattgagatg tgcaatgact taccgataat gctaagcgct
    12421 ccaagaatta agcctaaaac ggtgagtcac gttcagttca tttaaaaaac gcctgaaatc
    12481 attgagatag caggcgtttt gacgttttgt atggcatcat gaacaagaca agaaagtgaa
    12541 tgacggttgg caaatccaac gtattgtgag gtggtc
//
