LOCUS       c00054_JAIQWF0..       13372 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWF010000008.1 Streptococcus thermophilus strain CF2_14
            NODE_8_length_59252_cov_49.727740, whole genome shotgun sequence.
ACCESSION   JAIQWF010000008
VERSION     JAIQWF010000008
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:09:16
            Original ID  :: JAIQWF010000008.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13372
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13372
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2301:3372](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2302..3372
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13372
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13372
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(3..1259)
                     /locus_tag="ctg54_1"
                     /transl_table=11
                     /translation="MLVGLRIISILYDLFLASMLFYRPLSKINMKKKPLVALFFILIFH
                     GELVFLFSESRIFLVSNLLLNILEYYLIGLNFDYPIRQSSFWILLQTSLSLLAGAVLNQ
                     GIQLILPLGELSKNLEAISLYLGISFFLSTGITLILRKLLLSHQRLRIATSKGNWLYQF
                     IVPLLSIFFAFTISAIQGGVFGADYLSIISLSSLIVLTLSSLYFNLYLARQQQQYYHNQ
                     LEKEQLQFQVREIQQSQEEYQRLQSLRHDLKNKHLTLLSLLEKNPEEAKDYLYSLTDSI
                     VGEQTFYSKNQTINFLLNQKLHHLKDEIEMEIDCFVPQELSIQPDILAVILGNCLDNSI
                     AACLRLPNKERNLSLNIRYFQQNLFINIRNNFDEKEKSTRKSRQKDGWGLRNIDALVQE
                     YQGNIKHFIKDGQYQIEILL"
     CDS             complement(1259..1969)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 57.6; E-value: 2.2e-17)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg54_2"
                     /transl_table=11
                     /translation="MLKVAICDDSDRDASQLEHYLLSYDKFPLETKLYTNPQKLLNQRT
                     PDIHCVFLDINMPGINGIDVAQKIRKFNPFIPIIFVTSYRDYMEQVFEVQTFDYIVKPI
                     EPQKLMKVLDRILRFLDIGQALFTFSFGKHNYSVPSSDIVFFEKDKRSVFIYTKTGTYK
                     SLLKTKEILEKLPNYFIQIHASYILNPKYIKDFDSKTVTILLNGTEEHLLPISRKFQFS
                     FKEKYYSYLSERHF"
     CDS             2302..3372
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_3"
                     /sec_met_domain="ThiF (E-value: 2.7e-23, bitscore: 74.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 9.8e-13,
                     bitscore: 40.3, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSHCPRIKEIYPIYKLHDNLFRVGSQIGITTEISDEDDKMWSLV
                     NILDGRTINDVVDIMLTKYPDLTEQDIIGAIELLDKEGVIEEGATINCIKERYHSNIYY
                     FSRYLNSFKDSIDIQKRLNETTVLLLGLGGGGSNILTLLSGLGPKKIKIVDFDIIEKSN
                     LGRQFLYKEEDVGALKTQITCVNDLLPLLDNVDIVICVIDEPQYDIQRIVNKAVVTKNI
                     PCVFGASQVSRGRVYSVVPHQTGCFDCLNIHYTKIDSLFLEQFRGIRTVTKKIPTIAYG
                     PAMFQLTSAIVDEAVRLITKYAEPMSLNRQYEINYENGASFTHKPWGHYLDECPTCGNG
                     KEENWEIFSQYGEIKL"
     CDS             3369..4280
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 171; E-value:
                     5.6e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg54_4"
                     /transl_table=11
                     /translation="MTFETLTIENLTKSFDKQHFANNHIFLELEAAKITALIGHNGAGK
                     STLLKQMIGFIKPDQGDVHYGDISFIHNRKQARTMMSYMSQQYAPLEKLTVEQNLEMIG
                     RMRGLSTSELQKEIEHLLADLEIVEYRDKKGKNLSGGLKRLTSFAMALIGSADIMLLDE
                     PTNDVDPVRREKQWRLLQKLAYKGHTIIIVTHNLLEVEKYADNFALFNHGKLLKSGPVH
                     QMSYKNHYQISFNFVSKEFLSLFEHFTMVNGCVCQMEIEESELTRILIQVKEGIEKGLI
                     SNLSVKMKTLSISDLYKEELVN"
     CDS             4282..5004
                     /locus_tag="ctg54_5"
                     /transl_table=11
                     /translation="MTQFFYLLRWNYLRQKNLFILFTLAQVLLSVSLLFGYPLVIGKMD
                     TTTAYYLASGSVLMGVISIGCTISSPVIANAKSEGHVDYIRALPIPRILISLADLCIWL
                     IAILPGVFFTFLLGCLRFSVQLNLSILSVFVMLLICLTMISLGFSIAYIFSQNIVTLMS
                     QLILMIGLMFSPIMYPAGRLPDWLDQLYFLLPFVPSANLLRASFYRHGTVSLVDIGVLI
                     FWIFLTQLLILGTLQKEL"
     CDS             5193..6176
                     /locus_tag="ctg54_6"
                     /transl_table=11
                     /translation="MAKPIRVLLYYKYVPIENAEQFAADHLAFCKSIGLKGRILVADEG
                     INGTVSGDYETTQKYMDYVHSLPGMEDLWFKIDEEEEQAFKKMFVRYKKEIVHLGLEDN
                     NFDSDINPLETTGAYLSPKEFKDALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRE
                     LPQWVRDHKEEFMDKRVVVYCTGGVRCEKFSGWLVREGYKDVGQLHGGIVTYGKDPEVQ
                     GELWDGKLYVFDERIAVDVNRVDPIVVGKDWFDGTPCERYVNCGNPFCNRRILTSEENE
                     DKYLRGCSHECRVHPRNRYVSENDLSQEEVVARLAAIGESLDVTPA"
     CDS             6357..6554
                     /locus_tag="ctg54_7"
                     /transl_table=11
                     /translation="VAKNLRLKAARAEHDMTQGDLAEAIGATRQTIGLIEAGKYNPSLA
                     LCIAICKTLDRTLDQLFWED"
     CDS             6571..7062
                     /locus_tag="ctg54_8"
                     /transl_table=11
                     /translation="MKFKLINNKVTDEREKALNNKVAAECFYIMIAGTLVCIVYGSLFN
                     NGVISADCLLYPLLISSIWSIYRAERLDVNAFGSSSITVLGCLLVTGLITLMIMSANYR
                     YNHGIYHNNPLDSRYLMTWSITYIIYVPFVFLVNWALTALGRYERRRLEKHLDDLENEE
                     "
     CDS             7141..7911
                     /locus_tag="ctg54_9"
                     /transl_table=11
                     /translation="MLLTEFDANRQAIINPEALHEPLEGFPKIAVSCFSRLTFQRMLEM
                     FPHELIYETSMANVAIPIYKLVIDDNELAIFNAPVGASACVGILEDIFVLGADKLVLFG
                     TCGVLDEDIKETSIIIPSHALRDEGTSFHYVEASDEIAVNVGVLDHFRSYLNERQISHK
                     EGKVWTTDGVYRETNGKLKARKAAGAICVDMECSAVAALAKFRGVDICHFFYAADHLSE
                     GNWDARNLMNHMDLDEKDKIALLALEFACDWIKP"
     CDS             8005..8688
                     /locus_tag="ctg54_10"
                     /transl_table=11
                     /translation="LEDKNFAERLNILRAGVLGANDGIISIAGVVIGVASATSNIWFIL
                     ISALSAIFAGVFSMAGGEYVSVSTQKDTEEEAVAKEQALLDRSPESARESLYQTFLSQG
                     DCETEAEVKVNQAFSKNPIKVLVEEKYGVDMEEITNPWHAAVSSFLSFSVGSLPPTLAI
                     LLFPDPYRIPITAVVVALTLILTGYVSAKLGKAPVKQAMLRNLAVGLLTMLVTYVVGQV
                     FHVNV"
     CDS             8768..9487
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1154:Pseudouridine synthase (Score: 201.2; E-value:
                     2.1e-61)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_11"
                     /transl_table=11
                     /translation="MRLDKLLGQSGYGSRNQVKKLIRSRQVYVDGVLADRDNLNVDASL
                     QTIMVSGKELEHAPEVYYLMNKPSGVVSARKDKEHQTVIDLIRPEDQREGLYPVGRLDR
                     DTEGLVLITNNGPLGFAMLHPRYHVAKTYYVEVNDILGPDAPAFFESGVVFEDGTVCQS
                     AQLEVLSSASDKSCARVTISEGKFHQVKKMFLAYGVKVTYLKRISFGEFKLDEGMAVGS
                     YRTLTEAEKTILRTYLG"
     CDS             9723..10868
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244:amidohydrolase (Score: 364.6; E-value: 8.4e-111)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_12"
                     /transl_table=11
                     /translation="MTEVFYDHLAKTRHQIHQHPEVSGEEHETTVFLKAYLKNLGVEPL
                     NYPLKTGLIAEIGSGHPIIALRADIDALPIKEKTGLPYASDNGAMHACGHDFHQTSLLG
                     AAQLLKEREAELKGTVRLIFQPAEENFQGAYQVIEAGGIEGVSAIIGYHNNPHLKPGQI
                     GLRSGAILAGVEQFRVDVMGVSSHAARPDLGVDTVLVTTTIINNLQQIVARTVSPFESA
                     VLSVTHIEVGNTWNVLPAAGFFEGTIRTFEPKVREDVIARFEKVVQATADQFGAQVDIT
                     WGNSPYVTYNDQTLTPLIFENSKAFAEVIETLPSTGGEDFAAYQKEIPGVFAFVGSNGE
                     ENAPDWHHDDFLVKDEALPVAVNYYVENALFLLDYFKEQDD"
     CDS             11301..11438
                     /locus_tag="ctg54_13"
                     /transl_table=11
                     /translation="MLIGIPKEIKNNENRVALTPAGVQSLLAKGHVVLIETNASKFCYC
                     "
     CDS             11413..11751
                     /locus_tag="ctg54_14"
                     /transl_table=11
                     /translation="MRPSSVIVNVAVDQGGVVETVNRVTSHDKPVYETHSVLHYAVANI
                     PVAVARTSTIALTNVTLPYIEALTGVGFKQAIENDEGLRQGVTTYQGHITSQPVPEGLN
                     RSYTAIDE"
ORIGIN
        1 ggtaataaaa tctctatttg atattgtcca tcttttataa agtgtttgat attaccttga
       61 tattcttgaa caagagcatc aatatttcgc aacccccagc catctttttg acgggattta
      121 cgagtagatt tttctttctc atcaaaatta tttctaatat tgataaaaag attttgttga
      181 aagtatcgga tattaagtga taagtttctt tctttatttg gtagtctgag acaagctgca
      241 atactattgt ctaggcagtt tcctaatata acagctaaaa tatctggttg aatagataat
      301 tcttgtggta caaagcaatc aatttccatt tctatctcat cttttaaatg atgtagtttt
      361 tgattaagta aaaaattaat agtttgattt ttagagtaga aagtttgttc acctactata
      421 ctatctgtta atgaataaag ataatctttt gcctcttcag gatttttctc taaaagcgat
      481 aaaagagtta aatgtttatt ttttaagtca tgccgaaggc tttggagacg ttgatattct
      541 tcttgagatt gttgtatttc tcgaacttgg aactgtaatt gttctttttc caattggtta
      601 tggtaatatt gctgctgttg acgagcaagg tacagattaa aataaagaga ggagagagtt
      661 aatacaatga gagatgagag agaaatgatt gacaggtaat ctgctccaaa tacccctcct
      721 tgaatggcag atattgtaaa agcaaagaaa atagataaaa gaggcacgat aaactgataa
      781 agccagtttc ccttagaagt agcaatacga agcctttgat gggataggag aagctttcgt
      841 aagataagag ttattcctgt agataagaag aaacttattc cgagatacaa actaatagct
      901 tctaaatttt ttgatagttc ccctaaaggt aaaattagtt ggattccttg gtttaggaca
      961 gctcctgcta acaaacttag actagtttgt aaaagaatcc aaaaggaaga ctggcgaata
     1021 ggataatcaa aattgagacc gattagatag tattctaaaa tgtttagaag gagattactg
     1081 accaaaaaaa tacgactttc agagaatagg aacacgagtt ccccatgaaa aatcaatatg
     1141 aaaaaaaggg ctactaaagg cttctttttc atattgattt tagacaatgg tctataaaat
     1201 aacatacttg ctagaaataa atcgtacaag atactgatta ttcgtaatcc tactaacatt
     1261 aaaaatgcct ttcacttaga tagctgtaat acttttcttt aaaagaaaac tgaaactttc
     1321 tactaattgg gagtaggtgt tcttcagtcc catttagtaa aatagtaact gtttttgaat
     1381 caaagtcttt gatgtatttg gggtttaaaa tataggaagc atgaatttga ataaaataat
     1441 tagggagttt ttccaaaatc tcttttgttt ttagtagaga cttgtaggta cctgtctttg
     1501 tgtatataaa tactgaacgt ttatctttct caaaaaatac aatatcgctc gaagggacag
     1561 aataattgtg tttaccaaat gagaaggtaa aaagtgcttg gcctatatcc aaaaaacgca
     1621 aaatacgatc caatactttc attaactttt gaggttctat cggttttacg atatagtcaa
     1681 aagtctgaac ttcgaagact tgttccatat aatcacgata acttgtcaca aaaataatag
     1741 gaatgaaagg attaaatttt ctaatctttt gtgctacgtc aattccattg attcctggca
     1801 tattgatatc caaaaagaca cagtggatgt ctggcgtccg ctgatttaag agtttttgtg
     1861 gatttgtata aagttttgtt tctagaggaa atttatcata agaaagtaaa taatgttcta
     1921 attggctagc atctctatca gagtcatcac aaatagcaac ttttaacatt gaaaacctcc
     1981 tcactcattt ctgtatgtta gttataacgt taaaatggtc aattatgaca taattgtaag
     2041 aaaaatgtaa gtttagtata caatattctt attaaagatg aaaggagaat tccaaatgaa
     2101 aaacattcaa gtacgtaagg ccgtagctca aaccgaaatt agctggggta ttatttaatt
     2161 gcttaaaaat gttaaataaa catataagca aatgttacct tcgattctat cacggaaaat
     2221 ttttgataga attactacaa taaggcgagg ggaaattata gaatcacctc atctttcttt
     2281 ttgaaaaaca gtgaggaaaa aatgaaatcc cattgtccaa gaataaaaga aatatatcct
     2341 atttataaac ttcacgataa tttgtttagg gtaggctccc aaattggtat aactactgaa
     2401 atcagtgatg aggacgataa aatgtggagt ttagttaata ttttagatgg aaggactatt
     2461 aatgacgttg tagatattat gttaactaag tatccagatt tgacggaaca agatataata
     2521 ggtgctattg aactattgga taaggagggg gttattgaag aaggtgctac aataaattgt
     2581 attaaggaaa gatatcattc aaatatctac tattttagtc gctatttaaa tagttttaaa
     2641 gatagtatag atattcaaaa gagacttaat gaaacgacag ttcttttatt aggacttggc
     2701 ggaggagggt ccaatatact aactttgcta tctggtctag gacctaaaaa aataaaaatt
     2761 gtggactttg atatcattga aaaaagtaat ctaggtaggc aatttttata taaggaggaa
     2821 gacgtagggg ctcttaaaac acagataaca tgtgtaaacg acttgttgcc attattagac
     2881 aatgttgaca ttgttatttg tgttattgat gaaccacaat atgatattca gcgtattgta
     2941 aataaagctg tagttacaaa aaatattccg tgtgtttttg gtgcaagtca agttagtcgc
     3001 ggacgtgttt attctgtagt accccatcaa acaggatgtt ttgattgttt aaacattcat
     3061 tacacgaaaa ttgatagtct attcttggaa caatttcggg gtattcgtac tgttactaag
     3121 aaaattccta caattgctta tggtccggct atgtttcaat tgacatctgc tattgttgat
     3181 gaggctgttc gattaataac taaatatgca gaaccaatga gtcttaatcg ccaatacgag
     3241 attaattatg aaaacggagc gtcgttcaca cacaaacctt ggggacatta tcttgatgag
     3301 tgtcctacat gtggtaatgg taaggaggaa aattgggaaa tcttttctca atacggagaa
     3361 ataaaattat gacttttgaa acgctcacca ttgaaaattt aacaaaatca tttgataaac
     3421 aacattttgc taataaccat atcttcttag agctagaagc tgcaaaaatc acagctctta
     3481 taggacataa tggtgctggt aaatcaactc ttttaaagca aatgattggt tttattaagc
     3541 ctgatcaggg agatgttcac tacggagata tttcttttat acataaccgt aaacaagctc
     3601 gaacaatgat gagttatatg tcacaacagt atgcacctct tgaaaagtta actgttgagc
     3661 aaaatttaga gatgattgga agaatgagag ggttaagtac ctcagaactc caaaaagaaa
     3721 ttgagcacct tctagcagat ctggaaatag tagaataccg tgataaaaaa gggaagaatc
     3781 tttcaggagg cttaaaacgg cttacatctt ttgccatggc attaattggc tctgctgata
     3841 tcatgcttct tgacgaacca accaacgatg ttgatcctgt acgtcgtgaa aaacagtggc
     3901 gattattaca aaaactggct tataaaggac acactattat cattgttacc cacaatctac
     3961 tagaagttga aaaatatgcg gataattttg ctctttttaa ccatggtaaa ttattaaaat
     4021 ctggtccagt acaccaaatg tcttataaaa atcattatca aatttctttc aattttgtta
     4081 gtaaagaatt tttaagtcta ttcgaacatt ttacgatggt caatggttgt gtttgtcaga
     4141 tggaaattga agaaagtgaa ttaacccgaa tactcattca agttaaggaa ggtatagaaa
     4201 aagggcttat ttcaaacctt tcagttaaga tgaaaacatt atctatttcc gatctttata
     4261 aagaggagct tgttaactga tatgactcaa tttttttact tacttcgttg gaactatctt
     4321 cgacaaaaaa atctattcat tctattcaca ctagctcaag tgcttttgtc cgtttcactt
     4381 ctttttgggt atccgttggt aattggtaag atggacacaa caactgctta ctatcttgcc
     4441 tctggatcag ttttaatggg agttatttct attggctgta cgatttcatc tcctgttata
     4501 gccaatgcca agtcagaagg tcatgtggac tatattcgag ctttacctat tcctagaatt
     4561 ctaatttctt tagctgacct atgtatatgg ttaattgcta ttttaccagg tgtattcttc
     4621 acttttttat taggctgtct tcgcttttct gtccaattaa atttgtcaat tttgtctgtt
     4681 tttgtgatgt tacttatttg cctaacaatg attagtctag gattttcaat tgcttatata
     4741 ttttcccaaa atattgtcac gctaatgtct cagcttattt taatgattgg tcttatgttt
     4801 tcaccaatca tgtatccggc aggtcgtctt ccagattggt tagatcaact ttattttcta
     4861 cttccatttg tcccttctgc gaatcttctt agagctagct tttatagaca tggaactgtt
     4921 tcgcttgtag atataggagt tcttattttc tggatttttc tgacacaact gcttatctta
     4981 gggacactac agaaagagtt gtaatactat cttatggaaa acaatcttac gaaactcagg
     5041 tttagacatc tggcacttag cctttttctg ttgtgaaaat tcttctccaa acaaatcaat
     5101 tgcctagtcc tctttgatag cggtataata gttaagttga ttttattatc aaacaacaaa
     5161 tatagatatt tcataaagaa agaggaaata caatggcaaa acctattcga gtattgcttt
     5221 attataaata cgttcccatc gaaaacgctg agcaatttgc ggctgaccac ttggcttttt
     5281 gtaagtcaat cggtctgaaa ggtcgtatct tggtcgctga cgaggggatt aatggaacgg
     5341 tttctggaga ctatgaaacc actcaaaaat acatggacta cgttcatagc cttccaggga
     5401 tggaggacct ttggttcaag attgatgagg aagaagaaca agctttcaag aagatgtttg
     5461 ttcgctacaa gaaggagatt gttcaccttg gcttagagga taataacttt gatagcgaca
     5521 tcaatccact tgaaactaca ggtgcttact tgtcacccaa agagtttaaa gacgctcttt
     5581 tggatgagga tactgttgtc cttgatacac gtaacgacta tgaatatgac cttggtcact
     5641 tccgtggtgc cattcgtcct gacattcgca acttccgtga attgccacaa tgggtccgcg
     5701 atcataaaga agagttcatg gataagcgcg tggttgttta ctgtactggt ggtgtccgct
     5761 gtgagaaatt ctcaggttgg ttggtccgtg aaggctataa agatgttggc caattgcatg
     5821 gtggtatcgt gacttacgga aaagacccag aggttcaagg ggaactttgg gatggtaagt
     5881 tgtatgtctt tgacgagcgt attgccgttg atgtcaaccg tgtagatcct atcgttgtcg
     5941 gtaaggactg gttcgatggc acaccttgtg aacgctatgt caactgtggc aacccattct
     6001 gtaatcgccg tatccttact tcagaggaaa atgaagacaa atacctccgt ggctgctcac
     6061 acgaatgccg tgttcaccca cgcaaccgtt atgtctctga aaatgatttg agccaagaag
     6121 aagttgtcgc acgccttgcg gctattggtg aaagcttgga tgtaacacct gcttaagttt
     6181 aaatagagaa gaggctgaga gaaatcttgg ttttttattt tgcaatttat ttctaaaatt
     6241 atgaaatata tatatattgc aattagaaat atatagtgta taattaagat gaaaatagct
     6301 ggtgaaccta atcaatttca acgataatat cagatatgat gtaaaggagg gggcatgtgg
     6361 caaagaattt acgtttaaaa gcagctcgag cagagcatga tatgacccag ggtgacttgg
     6421 cagaagctat aggtgcaaca agacaaacca taggtttgat tgaagctgga aagtacaatc
     6481 ccagcctagc cttatgcatt gctatttgca agacactgga taggactttg gatcaactgt
     6541 tttgggagga ttaggaagga agtaaatacg atgaaattca aactgattaa taataaggtt
     6601 acagatgaac gcgaaaaagc tctaaataat aaggttgctg ctgaatgttt ttacataatg
     6661 attgcaggga cgcttgtatg catagtttat ggctccctct ttaacaatgg tgtcatctct
     6721 gctgattgct tactttatcc attgttgata agtagtattt ggtctattta tagagctgaa
     6781 cgtcttgatg taaatgcttt tggtagttcg agtataacag tcttaggttg tttactggtg
     6841 actgggctta tcacgcttat gataatgtca gctaactatc ggtacaacca tggtatctat
     6901 cataataatc ccctggattc tagatatctc atgacttggt caattactta tatcatttat
     6961 gttccctttg tctttttggt gaattgggct ctcacagcac tggggagata cgagagaaga
     7021 cgtcttgaaa aacatctaga cgatttggag aatgaagaat aaatagtgag agaatcagac
     7081 cattcttttt tgtctgattt ttttgtgtta taatggttcc taaaactaag gaggtcacgt
     7141 atgctactaa ctgaatttga tgcgaataga caagcgatta tcaatcccga ggccttacat
     7201 gagcctcttg aaggttttcc taaaatagct gtatcctgtt tttctcgttt gacctttcaa
     7261 cgaatgcttg agatgtttcc ccatgaactt atctatgaaa catccatggc gaatgtggct
     7321 attccgattt ataagcttgt tattgatgat aatgagttgg ccatttttaa tgcacctgta
     7381 ggcgcctctg cctgtgtggg tattttagag gatatttttg tcttgggagc tgataaactt
     7441 gtactttttg gtacttgtgg ggtgcttgat gaagatatta aagagacttc tattattatt
     7501 cctagtcatg cccttagaga tgaagggacg agttttcact atgtggaagc cagcgatgag
     7561 attgcggtaa atgtgggtgt tttagaccat tttcgttcct atctcaatga acgtcagatt
     7621 tctcataagg aaggcaaggt ttggacaact gatggcgttt accgtgagac gaatggtaaa
     7681 ctcaaagcta gaaaggcagc aggagccatt tgtgtggata tggagtgttc tgctgttgca
     7741 gctttagcaa agtttagagg tgttgacatc tgccacttct tctatgctgc ggaccacctt
     7801 tctgaaggta attgggacgc ccgtaacttg atgaatcata tggacttgga tgaaaaggac
     7861 aagatagctt tattagcttt ggagtttgcg tgtgactgga ttaaacctta aaaattctac
     7921 tttttagatt tattatttgt aatcaatcta aataactatt ataatacttt tttataatga
     7981 ttctaaataa ggagcgaaca attgttggaa gataagaatt ttgcagaacg tttaaatatt
     8041 ttgagagctg gtgtgttggg tgccaatgat ggcatcattt ccattgcggg agtggttatc
     8101 ggtgtggcta gtgcgacatc taatatctgg tttatcttga tttcagcctt gtcagcgatt
     8161 tttgccggtg tcttttcgat ggcaggtggt gaatatgtca gtgtgtcaac gcaaaaagat
     8221 accgaagaag aggctgtcgc taaggaacaa gcccttttgg atcgctctcc tgagtcagct
     8281 agagaaagtt tatatcaaac cttcctcagt caaggggatt gcgaaacaga agcggaagtt
     8341 aaggtcaatc aagccttcag taaaaatcct atcaaggtct tagttgagga aaaatatggg
     8401 gtggatatgg aagaaatcac caatccatgg catgctgccg tatctagttt tctgtccttt
     8461 tcagtgggat ctttgcctcc aacgctagct atcctgcttt tcccagaccc ttaccgtatt
     8521 cctataacag cggttgtggt tgcactgacc ttaatcttga ctggctatgt tagtgctaaa
     8581 cttgggaaag cacctgttaa acaagcgatg ttgcgaaact tggcagtagg actcttgacc
     8641 atgctcgtga cctatgtagt tgggcaagtc tttcatgtga atgtgtaatt gttagtagta
     8701 tgagtctacc ttttaggtag gctttttttg tctactagac cagacttatc catggtacaa
     8761 tagggctatg cgtttagata aattattagg acagtcgggc tatggttctc gcaatcaggt
     8821 caagaagctc attcgtagtc gtcaggtata tgtagatggt gtcctggcgg atcgagataa
     8881 tcttaatgtg gatgctagtc ttcaaaccat catggtttct ggtaaagaac tggagcatgc
     8941 gccagaagtc tactacctta tgaataagcc gtcaggagtg gtgtcagcta gaaaggacaa
     9001 ggaacaccaa acagttattg atttgattag gcctgaggat cagcgagagg gcctttatcc
     9061 tgtgggacgt ttggatagag atacggaagg tttggtgttg attaccaata atggtccctt
     9121 gggctttgcc atgcttcacc cacgctatca tgtggctaag acatattatg ttgaggttaa
     9181 tgatattctg gggcctgatg cacctgcatt ttttgagtct ggtgtggtct ttgaggatgg
     9241 gactgtttgt caatcagctc agctggaagt tttaagttct gcaagtgata aaagttgcgc
     9301 tcgagtcacg atttcagaag gtaagtttca tcaagtaaaa aagatgtttt tggcttatgg
     9361 ggtcaaggtg acctatctca agcgtatctc tttcggagag tttaaacttg atgaagggat
     9421 ggcagtaggt tcctaccgaa ccttgactga agcggaaaaa acaatcttgc gtacttattt
     9481 gggttagtag ctaaggtgcg ataggaactt tcaatcagct gataagacta tcttatcgct
     9541 agtcttaata cgacaacacc tataatgaca gtatttttta gaggtataag aaatacttat
     9601 ggaatactat aagtattttt gatttctcaa gtatcgcttc tggtggtatg atgaaatcaa
     9661 ttcgattgag agtttcacaa atagattgac aatccaaaac tgatcagaga gggaggttca
     9721 ttatgacaga agtattttac gatcatttag caaagacgcg tcatcagatt caccaacatc
     9781 cagaggtttc tggggaggag catgagacga cagtcttttt gaaagcttat ttgaaaaatc
     9841 taggtgttga gcctttaaat tatcccttga agacaggact catcgctgag attgggtcag
     9901 gtcatcctat tattgccttg cgtgctgata ttgatgccct accgattaag gaaaagacag
     9961 gtcttcctta tgctagcgac aatggtgcca tgcatgcttg tggtcatgat tttcaccaga
    10021 cctctctgct tggtgctgct cagcttttaa aagaaagaga agcagagctt aaggggactg
    10081 ttcgattaat ttttcaaccg gctgaggaaa atttccaagg ggcctatcag gtcattgaag
    10141 cgggcggtat tgagggtgtg tcagctatca tcggttatca caataatcct cacttgaaac
    10201 ctggtcagat tggccttcgt tcaggtgcta ttttggcagg cgtggagcag tttagggttg
    10261 atgtcatggg tgtttcgtcc catgcagccc gtcctgattt gggtgtggat acggtcttgg
    10321 ttactacgac tatcattaat aatttacagc aaattgttgc tcggacggta tctccctttg
    10381 agtcagctgt attgtcagta actcatatcg aagttggaaa tacctggaat gttcttccag
    10441 cagccggctt cttcgaagga acgattcgga ctttcgagcc taaggttcgg gaagatgtca
    10501 ttgctcgctt tgaaaaagtt gttcaggcga cagcggatca gtttggtgct caagttgaca
    10561 ttacttgggg taattcacct tacgtgacct acaatgacca gacactcaca ccactcatct
    10621 ttgaaaattc taaagccttc gcagaagtga ttgaaacgct gccatcaaca gggggcgaag
    10681 actttgcggc ctatcaaaag gaaataccag gagtctttgc ctttgttggc tcaaatggtg
    10741 aagaaaatgc accagactgg caccatgatg atttccttgt gaaagatgag gccttgccag
    10801 tagctgtgaa ttactatgtg gaaaacgctc ttttcctcct tgattatttt aaggagcaag
    10861 acgactgact attcccttaa ttggaatcac tagtaatgaa aaaactgttg cggaaagaag
    10921 tccaatcatc cagagtttct cttgggtcat aagcaattag cagaccaagg actctttgat
    10981 tattttatta agagttttcc atgaagctta aggattttaa attggtgctg cttttgaaaa
    11041 taaaaaggag gatgtgcata agaaaaaata ctcttttgat catttagttt acaacttaag
    11101 agcccagccg attggttggg ttcttttgtg aattgtttag atagttaggg gagtatgatt
    11161 ctaaggtctt aaaatagcgg agattttttt ctcttgattt tagttaaaat gaaagcgata
    11221 ttattacaga aagatagata ggaagtggtt aagcaattta cacaatcctt taccttacga
    11281 cctccgaatg aggagaaaat atgttaattg gtattccaaa agaaatcaaa aataacgaaa
    11341 accgtgtagc tcttacacct gcaggtgtcc aaagtctttt ggctaaggga cacgtagtat
    11401 taatcgaaac aaatgcgtcc aagttctgtt attgttaacg ttgccgttga ccaaggtggg
    11461 gttgttgaga ctgtgaatcg tgtgacaagt cacgataagc ctgtttatga aacacacagt
    11521 gtccttcact atgctgttgc taatattcca gttgcagtag cacgtacatc aaccattgct
    11581 cttaccaatg ttacccttcc ttatatcgaa gctcttacag gagtaggctt taaacaggct
    11641 attgaaaatg acgaaggcct tcgccaaggt gtaacgactt atcaaggtca catcactagc
    11701 caacctgttc cagaaggatt gaatagaagc tatacagcta ttgacgagtg actataagtt
    11761 tataattcta tcagaatgaa agagaagtcg cgccatgaat tggtgtgact ttttttagtt
    11821 aggataagag gtaatcgtgt gtttggtagt tgattgtcaa gtgtctataa agcttaaatc
    11881 tgcttatttt tttctaatct aggtattgtt ttatgctata atgagcagac atcttaacat
    11941 tagtaatgag tacctatgac tctttctgtt tttacttaaa aaatgcgctc ataaagaggt
    12001 tttaccatgg ccaatcttat tcgtgttctc acagaaatta ttttctctta gcttgtcgtc
    12061 ttttattttg gtgtaaaaat cgatgtatca ttgaccaagt ttctaattac aataggtgtg
    12121 gtagcgctgc ttgaaatgat ttaccatgtg atacttgctc gaagataaga gcaaatattt
    12181 ctttcgaagc tttttggaga aactgtggac aactctttag aaaaaatgtt gtgttcttcg
    12241 tttttttagt tttttaccac ataattttca aagggtgcat atatctccat taacataaga
    12301 tatgaaatcg gttatatcaa aagctgtagc ttttttattt tccagttcag atatgtgcgg
    12361 tctgaaaaat taaatgatat aatgtcaata aataggagga tacagaaatg ttgaactatg
    12421 atttgattgt tatcggtttc ggtaaagccg gtaaaacgtt ggctgctaag atgaatgcgg
    12481 ctggtaagaa agttgctgtc atcgagcgca gtaaagctat gtatggtggg acttgcatta
    12541 atattgcgtg tatcccaact aagactatga ttgttgcggc tgagaagggc tggtcatttg
    12601 acgacaccat gaaagaacgt ggtgcagtga ctagtcgtct taatgctaag aattataaaa
    12661 tgttggcaga caatggcgtt gatgtcattg atgcagaggc acattttgtg tcaaataagg
    12721 ttattgaagt agtagctggg gatgaccgcc aagagcttac agctgagact attgttatca
    12781 atactggtgc tgtatctaat atcttgccta ttcctggttt gacaacaact aagcatgttt
    12841 acgactcaac tggcattcaa actcttgaag ctttgccaaa acgcttgggt atcctaggtg
    12901 gtggtaatat cggtcttgaa tttgctggcc tttataaccg tttgggtagt caagtgactg
    12961 tcttggatgc agcgactagc ttcttgccac gtgtagagcc atctattgct aagttggcca
    13021 agcaatacat ggaagaggac ggcattgtct ttgagcaagg tgttagaaca tctgaagtta
    13081 agaatgatgg tgatgaagtt gtcgttgtta ctgacaaagg ggacttccgt tttgatgctc
    13141 tcctctatgc gacaggacgc aagcctaata tcgaacctct tcacttggaa aatacagata
    13201 ttgccttgac agaacgtggc ggtattcagg ttaataagca tttggaaaca agcgttcctg
    13261 gtgtatttgc agtgggtgat gttaatggtg gacttcaatt cacttatatt tcattagatg
    13321 atttccgtat tgtctttaat tacttgacag gggatggtag ctataacctt ga
//
