LOCUS       c00037_JAIQWF0..        6818 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWF010000043.1 Streptococcus thermophilus strain CF2_14
            NODE_43_length_6818_cov_27.883040, whole genome shotgun sequence.
ACCESSION   JAIQWF010000043
VERSION     JAIQWF010000043
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:09:16
            Original ID  :: JAIQWF010000043.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6818
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6818
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[304:3196](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      305..3196
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..6818
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6818
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             2..115
                     /locus_tag="ctg37_1"
                     /transl_table=11
                     /translation="RLEELQKDGTLAKLAEKFFGNKDYIPTKDALKVPSKK"
     CDS             305..3196
                     /NRPS_PKS="Domain: AMP-binding (6-388). E-value: 6.9e-65.
                     Score: 210.9. Matches aSDomain:
                     nrpspksdomains_ctg37_2_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     172.5; E-value: 2e-52)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_2"
                     /sec_met_domain="AMP-binding (E-value: 9.9e-65, bitscore:
                     206.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.5e-07, bitscore:
                     20.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILKTFSDTVKQYPSKVAVMYSGGEFTFQEVDVMSNFIAKQLLL
                     NSDEETVPFYIEKNKYVLPVVLGIMKSGKIPLPITNSLEVKISLERISEVVFDVLISDR
                     DVKLENHSVTLLLLPKKLESYSEYQEVATTKENEIAHIICTSGTTGVPKKVFLTDDNID
                     WLVKEFYKIVKFTSESKFLFTTPYTFDVSLTEILAPVYTGGTLVCYDGGIQNIIRLGET
                     IEKKKITHLSLSPSFAETIIDISGPEVFQNLRALCLAGETFPSSLANRLRGLIQQGCRV
                     FNLYGPSETTIYATYYELKDRKYNTVPIGKPLPGVQLKIASQKENSKMAELLIGGNGVT
                     EGYRLQPELNKAKFKLIGSNRYYVTGDYVYYQGDNLVFSSRIDSQVQVNGIRIELDEVK
                     SIVDKLKSVKSSRVVFYKKKLVVFYEADLNIKEDIIRSLPSYLNPTVVKVESYYLNQNR
                     KLDVPKMLEIYYYKKQSQQGDDVRKNILDVLSKFERVDITDLDSLELVRFYLEIEDIFD
                     IEIKENDFYRLKSVDSIVDYIRNKSFFQERSTEPNDSFTKEHDLVNLEYNLTKMNYRYL
                     KNIITPSPTQKRLYKNNQNRVIGFNLALEEVTYLELNKLHHIIKYLSYKIDIFRLVVEK
                     EQTRFSIGIVNEGDYSPNIIVLNNLPTELELQGILDNIEVIPIPIIVVGTRDKKVRFYF
                     PYHSIDASSLNKLGDTVYQLYEKKIVIDEVPSSSLVAFSQFKREVLQNDVSGDVLARLP
                     KIKPAIEFEKLNDEVQCFQVSLPEDIKGDDVYLFTIYAISQCILSDYNLSAISGGLSLD
                     FRDYEQFDAYDLIGDIHKKIPFQVNRTETFEEFKNSHFKILEIYRTGIDYYEIAMLGND
                     MSAKEVQERLNNLSLSINFIGEAFRLKDTINNIIDVDFDKNFINVFVHERFAYAVIKSE
                     LLSNSVYDLMHKDSKFELKVIDKKRLENEETNR"
     aSDomain        323..1468
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg37_2_AMP-binding.1"
                     /evalue="6.90E-65"
                     /label="ctg37_2_AMP-binding.1"
                     /locus_tag="ctg37_2"
                     /protein_end="388"
                     /protein_start="6"
                     /score="210.9"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FSDTVKQYPSKVAVMYSGGEFTFQEVDVMSNFIAKQLLLNSDEET
                     VPFYIEKNKYVLPVVLGIMKSGKIPLPITNSLEVKISLERISEVVFDVLISDRDVKLEN
                     HSVTLLLLPKKLESYSEYQEVATTKENEIAHIICTSGTTGVPKKVFLTDDNIDWLVKEF
                     YKIVKFTSESKFLFTTPYTFDVSLTEILAPVYTGGTLVCYDGGIQNIIRLGETIEKKKI
                     THLSLSPSFAETIIDISGPEVFQNLRALCLAGETFPSSLANRLRGLIQQGCRVFNLYGP
                     SETTIYATYYELKDRKYNTVPIGKPLPGVQLKIASQKENSKMAELLIGGNGVTEGYRLQ
                     PELNKAKFKLIGSNRYYVTGDYVYYQGDNLVFSSRIDSQVQV"
     aSModule        323..1468
                     /domains="nrpspksdomains_ctg37_2_AMP-binding.1"
                     /incomplete
                     /locus_tags="ctg37_2"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       722..778
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg37_2_0001"
                     /evalue="1.00E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg37_2"
                     /protein_end="158"
                     /protein_start="139"
                     /score="15.1"
                     /tool="antismash"
                     /translation="AHIICTSGTTGVPKKVFLT"
     CDS_motif       1295..1366
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg37_2_0002"
                     /evalue="2.80E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg37_2"
                     /protein_end="354"
                     /protein_start="330"
                     /score="19.7"
                     /tool="antismash"
                     /translation="ELLIGGNGVTEGYRLQPELNKAKF"
     CDS_motif       1442..1498
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg37_2_0003"
                     /evalue="2.60E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg37_2"
                     /protein_end="398"
                     /protein_start="379"
                     /score="20.0"
                     /tool="antismash"
                     /translation="SRIDSQVQVNGIRIELDEV"
     CDS_motif       2078..2125
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg37_2_0004"
                     /evalue="1.30E+01"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg37_2"
                     /protein_end="607"
                     /protein_start="591"
                     /score="-0.8"
                     /tool="antismash"
                     /translation="NNQNRVIGFNLALEEV"
     CDS             3193..4839
                     /locus_tag="ctg37_3"
                     /transl_table=11
                     /translation="MSIYKDIVEGYQLNNIQEKDKLNNVLVQLNEKDDQEMINRKNFIG
                     HFTASAFVISKDNRRLLMVHHNILKRYLQPGGHIDKNDRNPLDAAKRELFEETGIDSEI
                     LTYQCAEPLNSLIPFNVSVHKIPENKLKNERSHYHYDLQYLFYIENEVDVKIDSNESSS
                     YEWIQLDNVKDMDGYKEIIKKIEKLEAASQERFLSNMLKGASFEDISCITVQHIIPSTI
                     PIIMTLQKIFGHRLLVCAKPNSVDKMVWHKLENMGVRLTLASRDEYFNVDYLGIKSKTI
                     LLDIGGYFASIAQIPNLPIECIIEDTENGIQKYENVIDQIEYPLFSVARNPLKKNEDYL
                     VGADIVFGTDYILHQKNLLMQYMQVVCIGYGKIGYGICTKLRELGIRPKVLEKDSMRTI
                     QAVRDGCDILLEKDFKNIDLIFCATGSKSLDILDFRSIKDGTFLVSATSSDDEFNYSYL
                     LDEYEEIVETSLITRYESEDNYFYLLNQGTPTNFVVNSALGNYILLVQAAILYTAKKFI
                     EDREMAIAKQVNTLSDEDNYNIAKQWLEEFC"
     CDS             4865..6073
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 278.7; E-value: 1.3e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg37_4"
                     /transl_table=11
                     /translation="LNKKEQQNTYLLVGSRIISRVGDIMFDFANNTFLSSVNVKSLMLV
                     GIYQTLENIISVIFNLFGGVLSDNFQRKRIIILTDILSGVLCLALSFISNQQWLIYAVV
                     ITNIILAFFSSFSGPAYKAFTKEVVEADNISKLNSLLESFITVVKVVVPLVSVSLYGLL
                     GLYGILRLDGITFIASGLLILFIRPILEESTGKQVFSLSKIFSDLFEGGRYLASQKEIL
                     YLVILSAIVNFFLAAYNLLLPYSNQMFPRVTVGLYGVFLGAEAVGGLIGASLSSILNKV
                     LKIKTMILYLGVSGVFLSLTPMVYCVFPSAYMLALYPALFNLFLTMFNLQFFSYIQKNV
                     DNVFLGRVFGIIFTVAILFMPIGTMTFTFLLSPKNIFNFVIVGLSIGGISLLFYRIFSK
                     RLR"
ORIGIN
        1 acgtttggaa gaactccaaa aagatggtac tttggctaag ttggctgaaa aattctttgg
       61 aaacaaagat tatattccaa ctaaagatgc tttgaaagtt ccaagcaaaa aataagaaag
      121 tctcttttgt caactgtagt cggtgacgaa aagcctttgt ttattatatg ataaataaaa
      181 gagggaaatg atgaaaaagg taaaattttt gccaactttg aaaattgctt ttgaaattct
      241 tattgttgtg tgtggataaa ttatgaatga cagtgcataa tcaatcaaat taaggagaag
      301 agaaatgacc atattaaaaa cttttagtga tacggtgaaa caatatcctt ctaaagttgc
      361 tgttatgtat agcggaggag agtttacttt tcaagaagta gatgtgatgt ctaattttat
      421 tgctaagcag ctactactca atagcgatga agagactgta cctttttata tagaaaaaaa
      481 taagtatgtt ttaccagttg ttttggggat aatgaaatcg ggtaaaattc cgttacctat
      541 aacaaatagt cttgaggtca aaatatcatt agaacgtatt agcgaagttg tctttgacgt
      601 gttgataagt gatagggatg ttaaacttga aaatcattca gtaactcttt tgctcttacc
      661 caaaaaatta gaaagttaca gtgagtatca agaagtagct acaactaaag agaatgaaat
      721 tgcacatatt atctgtactt ctggaactac tggggttcct aaaaaagtat ttttaactga
      781 tgataacata gattggcttg taaaagaatt ttataaaatt gtgaagttta cttccgaatc
      841 aaaattttta tttacaactc cctatacttt tgatgtttca ttaacagaga ttttggcacc
      901 tgtatatacg ggtggtactt tggtttgtta cgatggtggg attcagaata ttattcgact
      961 aggagaaaca attgagaaaa agaagataac tcatttatca ttatctccgt cttttgctga
     1021 aactattatt gatattagtg ggccagaagt attccagaat ttaagagcgt tgtgtctagc
     1081 aggtgagaca tttcctagtt cattagcgaa taggttgaga gggcttattc agcaagggtg
     1141 tcgagtattt aatttatatg ggccttcaga aacaacaatt tatgcaacct actatgagtt
     1201 gaaagataga aaatataata ctgttccaat tggtaagcct ttgcctgggg ttcaactaaa
     1261 gatagcttct caaaaagaga attctaagat ggcagaactt ctaattggtg gtaatggagt
     1321 aacggaaggg tatagactac aacccgaatt aaataaagct aagtttaagt tgataggttc
     1381 aaataggtac tatgtaacgg gggactacgt ttattaccaa ggagataact tggtatttag
     1441 ttcaagaata gatagccaag tccaagtaaa tggtattcgt attgaattag atgaggtaaa
     1501 atctattgta gataaactta aatcagttaa atcatcacga gttgtttttt ataagaagaa
     1561 acttgtcgta ttttatgaag ccgatttgaa tattaaagaa gatattatta gaagtttacc
     1621 tagttactta aatccgacgg tagttaaagt tgagagttat tatctcaatc agaatagaaa
     1681 gttggatgtt ccaaaaatgc ttgagatata ttattataaa aaacaaagtc aacaaggaga
     1741 tgatgttaga aaaaatattt tagatgtact atctaaattt gaaagagttg atatcacaga
     1801 tttggattcg ttagaattag ttagatttta tttagagatt gaggatatct ttgatattga
     1861 aattaaagaa aatgattttt ataggctaaa gagtgtagat tcgattgtgg actatattag
     1921 aaataaatca ttttttcaag aacgttcaac tgagccaaac gatagtttta ctaaagaaca
     1981 tgacttggtt aatttagagt ataatctcac aaaaatgaat tatcgttatt tgaaaaatat
     2041 tattactcct agcccgacac aaaagagact ttataaaaac aatcaaaatc gtgttattgg
     2101 ttttaattta gcactggaag aagtgactta tttagaattg aataagctgc accatattat
     2161 taaatattta agctataaaa ttgatatatt tagacttgtt gtcgaaaagg agcaaactcg
     2221 atttagcata ggtattgtga atgaaggaga ttactcacct aatattattg tactaaataa
     2281 tttaccaaca gagttagaat tacaaggaat attagataat atagaagtga ttcctattcc
     2341 aattattgtg gtgggaacaa gagataaaaa agtaagattt tattttccat atcattctat
     2401 tgatgcatca tcattaaata aacttggaga tacagtatat caactgtacg aaaaaaagat
     2461 agttattgat gaagtaccta gtagttcact ggttgctttt tcgcagttta aaagggaggt
     2521 gttacagaat gatgtctctg gggatgttct tgctagattg ccaaagataa agcctgctat
     2581 tgagtttgag aaattaaatg atgaagttca atgttttcaa gtttctttac cagaagatat
     2641 taaaggagac gatgtatatc tttttacaat ttatgctatc tcacagtgta ttttaagcga
     2701 ctataatctg tctgctatat ctgggggtct atctttggat tttagagatt atgaacagtt
     2761 tgatgcgtat gacttaatag gagacattca caagaaaatt ccattccaag taaatcgaac
     2821 tgaaactttt gaggagttta aaaactctca tttcaaaatt ttggagatct atcgtacagg
     2881 tattgattac tatgaaattg caatgttagg aaatgatatg agtgctaaag aagtgcaaga
     2941 acgattaaat aatctgtctc tatcaataaa tttcattggc gaagcattta ggttaaaaga
     3001 tactattaat aatataattg atgttgattt tgataaaaat tttattaatg tatttgtaca
     3061 tgagcgattt gcatacgcag ttataaaatc tgagttattg agtaatagtg tttatgactt
     3121 aatgcataaa gatagcaaat tcgagctaaa agtaattgat aaaaaacgac tggaaaatga
     3181 ggagacaaac cgatgagtat ttataaagat atagtagagg ggtaccaact gaataatatt
     3241 caggaaaagg ataaattgaa taacgttttg gtacagctta atgaaaaaga tgatcaagag
     3301 atgataaata gaaagaattt cattgggcat tttacagcat cagcatttgt tatttcaaaa
     3361 gataacaggc gtttattgat ggttcaccat aatattttaa aaagatacct acagcctggg
     3421 gggcatattg ataaaaatga tagaaacccg ctagatgcag cgaaacgtga gctgtttgag
     3481 gagactggga tagattctga aatattgacg tatcaatgtg cagaaccatt gaatagcttg
     3541 atacctttta atgtttctgt gcataagata ccagaaaata aattgaagaa tgagcgttcc
     3601 cactaccatt atgacttgca atatttattt tatattgaaa atgaggttga tgtgaaaatt
     3661 gacagcaacg aatcgagttc ctatgagtgg attcagctag ataatgtaaa ggacatggac
     3721 ggctataagg aaatcattaa gaagattgaa aaacttgaag cagcttctca agaacgtttt
     3781 ttatctaata tgctgaaagg tgcatcgttt gaagacatat catgtattac tgtacaacat
     3841 attattccaa gtacaatacc gattatcatg acattgcaaa aaatatttgg gcatcgtttg
     3901 ttagtgtgtg ctaaaccaaa ctctgttgat aagatggtat ggcacaagct agaaaatatg
     3961 ggggtaagat taacattagc ttcaagggat gaatatttta atgtagatta tctggggata
     4021 aagagtaaaa caattttatt agacattggt gggtattttg cctcaattgc tcagattcca
     4081 aacttaccta tcgagtgtat cattgaagat acagaaaatg ggattcaaaa atatgagaat
     4141 gttattgatc aaatagaata tccgttattt tctgtcgcta gaaatcccct gaagaagaat
     4201 gaggattact tagttggtgc ggatattgtt tttgggacag attatatatt acatcaaaaa
     4261 aatttattaa tgcaatatat gcaagtggtt tgtattggat atgggaaaat cggttacggc
     4321 atctgtacca aattaagaga acttggtatt agaccgaagg tgctggaaaa agatagcatg
     4381 agaactattc aagcggtacg tgatggttgc gacattttgc tagaaaaaga tttcaagaat
     4441 attgatttga ttttttgtgc gaccggttca aaaagtctag atattttaga ttttcgctct
     4501 atcaaagatg gaaccttcct agtctctgca acatctagtg atgatgaatt taattatagc
     4561 tatttattgg atgaatatga agaaatagtc gaaacttcat taatcactag atatgaaagt
     4621 gaagacaact atttctatct gttaaatcaa ggaacaccaa ctaattttgt agtaaactcc
     4681 gctttgggaa attatatttt attagtccag gcagccattc tatatacagc taagaagttt
     4741 attgaagata gagaaatggc tatagctaag caagtaaaca ctctttcgga tgaggataac
     4801 tataatattg cgaagcaatg gttagaagag ttctgctaat gaacaaatat ctgaggagtt
     4861 tattttgaat aaaaaagaac aacaaaatac atatttactt gtagggagcc gtattatttc
     4921 tcgtgttgga gatattatgt ttgactttgc gaataacact tttttatcga gtgtaaatgt
     4981 taagtcactt atgttagttg gtatttatca gacattagaa aacatcatca gtgtgatttt
     5041 taatcttttt ggtggtgttc tgtctgataa ctttcaaaga aaacggatta tcattttaac
     5101 agatatttta agcggagtat tgtgtcttgc cttatctttt atttctaatc agcagtggtt
     5161 gatttatgct gtggttatca caaacattat attagctttt ttctcatcat tttcaggccc
     5221 tgcttataag gcttttacta aagaagtggt ggaagcagat aatatttcaa aactaaactc
     5281 attactagaa tcgtttataa cggtagttaa agtcgttgtt cccctggtat cggtatctct
     5341 atacggttta ctaggattat atggtatttt acgtctagat gggataacat ttattgcatc
     5401 tgggttgctt attctcttta ttcgtcccat acttgaagaa agtactggga aacaggtgtt
     5461 ttcattatcg aaaatctttt cagatctttt tgaaggagga aggtatctag ctagtcaaaa
     5521 ggaaattttg tacttggtta ttttatctgc gattgttaat ttctttttag cagcttataa
     5581 tctgttgtta ccatatagca atcagatgtt cccaagagtt accgttggct tatacggtgt
     5641 tttcctagga gcagaagcag taggtggtct tattggagcg tctttaagca gtattctcaa
     5701 taaagttttg aaaataaaaa caatgatttt atatcttgga gtatcaggtg tttttctatc
     5761 tttgacacct atggtatact gtgtttttcc aagtgcttat atgcttgcgt tatatcctgc
     5821 tttattcaac ttgtttttga ctatgttcaa cttacagttt ttttcatata tccaaaagaa
     5881 tgtggataat gtctttcttg gtagagtttt tgggattatt tttactgttg caattttatt
     5941 tatgcccatt gggacaatga catttacttt tcttttaagc cctaaaaata tctttaattt
     6001 tgttatcgtt ggtttatcta taggaggtat ttcgcttctc ttttatagga tttttagcaa
     6061 aagattgagg taaattttca gagtaatttt agctccgatg gcgtagtaaa attgcttagt
     6121 aaagtcacaa tttatatact tgttagggca accattacac acataaggta atcgttttag
     6181 aagtgggcgg gcctcacatt ttgagtgttg attgattcct tgatggtaag gtgtttacat
     6241 acttttttag agacagtaga tgggtcgccg attagtttag aaatagctct aaatgtcttg
     6301 ttcgtttctc ataaaagtca gcgatattgc agggattggt atgactagct gaagcgatgt
     6361 tgtgaatgta cttgaacaag attttactgg catagggatt ccctcgttta gtgatgtgtt
     6421 ccttagcgag aaagttccca gattcatagt gtctcaggtc aatgccaata aaagcgttga
     6481 tttgattggt atactgcgac gaatatctcc caattcgcca atgatagatg tcgctgtggt
     6541 ttctgcgatg ccaggaattg accgtaagat gtcatactct ggtaaaggct gagctagagc
     6601 taccatgtcg tttaagacaa cccgtctgcg ttcagaaaga cgaagcaatt cggctctttg
     6661 tcaaacaatt gatattttta ggtgatagta ttttcttatc actttgatta tgtttaagta
     6721 ttagttaagc ttagtgaatt ctgttacaat aaaaaaaatc aatctcaaag gagagtatta
     6781 tgaaacttaa aaaaattctt ggaattacgg gtgtagcc
//
