LOCUS       c00001_JAIQWI0..       15310 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWI010000010.1 Streptococcus thermophilus strain DS61_14
            NODE_10_length_62611_cov_287.195649, whole genome shotgun sequence.
ACCESSION   JAIQWI010000010
VERSION     JAIQWI010000010
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 04:25:23
            Original ID  :: JAIQWI010000010.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 47301
            Orig. end    :: 62611
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15310
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[57301:62412]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15111
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15310
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15310
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2151..5732)
                     /locus_tag="ctg1_66"
                     /transl_table=11
                     /translation="LAGHDVQYGKHRTRRSFSRIKEVLGLPNLIEIQTDSFKEFLDTGL
                     KEVFEDVLPISNFTDTMELEFVGYELKEPKYTLEEARIHDASYSAPIFVTFRLINKETG
                     EIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVI
                     PNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIVDIFGDSELVRNTIE
                     KDIHKNPADSRTDEALKEIYERLRPGEPKTADSSRSLLVARFFDPRRYDLAAVGRYKLN
                     KKLNIKTRLLGQTIAENLVDPETGEILVEAGTEMTRDVIDSIAEHLDGDLNKFVYTPND
                     YAVVTEPVVLQKFKVVAPNDPDRVVTIVGNANPDDKVRALTTADILAEMSYFLNLAEGI
                     GKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNEALTPQQIINIRPV
                     TAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGR
                     MCPIETPEGPNIGLINNLSTYGRLNKYGFIQTPYRKVDRATGKVTNEVVWLTADEEDEY
                     IVAQANSKLNEDGTFAEEIVMGRHQGVNQEYPSHLVDFVDVSPKQVVAVATACIPFLEN
                     DDSNRALMGANMQRQAVPLIDPKAPFVGTGMEYQAAHDSGAAVIAKHDGKVVYSDADKV
                     EVRREDGSLDVYTIQKFRRSNSGTAYNQRTLVKVGDIVEKGDFIADGPSMEGGEMALGQ
                     NPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEFESETRDTKLGPEEITRELPNV
                     SEEALKNLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDT
                     SLRVPHGGDGVVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGV
                     VSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIYIATPVFD
                     GASSEDLWDTVREAGMDSDAKTILYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARS
                     VGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNILQEILTYKSDDVNGRLKAYE
                     AITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDYEVELRDLDEGEDDDVMHVDD
                     LEKARVQQAKEAAELEKAKEEALDKTE"
     CDS             complement(6095..8518)
                     /locus_tag="ctg1_67"
                     /transl_table=11
                     /translation="MNFEKIINYFRRLGQTIRTKFAGSRSKRGDKSFKERKATTGFKWN
                     RKQARKSPEDGMTLLDMGDVFLKTLKLLSDFFYVVIIVLTLFGAGIGLGYLGSQIQSVP
                     LIKDKTLLNQIGEVSLVSSMSYSDSKKIADIDTDLLRTPIESDAISNNVKNAIIATEDE
                     NFNKHKGVVPKAVFRALVSSVLGVGSSSGGSTLTQQLIKQQVTGDTPTFKRKAAEIIYA
                     LQLERHASKNEILTDYLNVSPFGRNNKGKNIAGIEEAAQGIFGVSAADLTVPQAAYLAG
                     LPQSPIVYSPYTADGQLKNEKDLSYGLARQKDVLYNLYRGGYLDKSQYESYKSYDVTKD
                     FKAGENPDAVSHDYLYYSVMSEAQDIMYDYLVKRDKVSSQDLKNDKTKEAYREMALREL
                     QTGGYHVKTTIDNAVYHAMQDTANKYGDLLDQGGNNGVEVGNVLMDNATGAILGFVGGR
                     NYENNQNNHAFDTARSPGSSIKPIIAYGIAIDQGLMGSSSILSNYPTNFTGGTPILHDG
                     DKGTAMMNLQEALNTSWNIPAFWTYQMLQHHDVDVEGYMTKMGYKIANYNIESLPLGGG
                     IETTVAQQVNAYQMLSNGGVYEKGYMIDSITDSTGEVIYQHKSKGVQVFTRATASIMDN
                     LLKEVVVKGATTQFYSELKNVNGAAASADWMGKTGTTDNFADAWLVVSTPGITLGGWAG
                     YDDNAPTNSKMGYTYNAQYMARLTSAIYNANPGIFKTGDKFNIDSSAIKASVLKSTGLK
                     PATVSVNGRNVSVSGEMVDSYWAKNGPGDTIYKFAIGGTDSDYQKAWSSILGEH"
     CDS             8619..9875
                     /locus_tag="ctg1_68"
                     /transl_table=11
                     /translation="MTIFEELKARGLIFQTTDEEALVKAFEEGPVSFYTGYDPTADSLH
                     LGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFNDAERSLQTKETVEGWVEKIQGQ
                     LSRFLDFENGDNKAVMVNNYDWFGSVSFIDFLRDVGKYFTVNYMMSKESVKKRIETGIS
                     YTEFAYQIMQGYDFYELNAKYGVTLQIGGSDQWGNMTAGTELLRRKADKSGHVITVPLI
                     TDSTGKKFGKSEGNAVWLDATKTTPYEMYQFWLNVMDDDAVRFLKIFTFLSLEEIEEIG
                     KEFDQARHQRLAQKVLAREVVTLVHGKEAYEQAVHITEQLFAGNLKALSARDLKVALNG
                     VPTYEISADENLNIVELLVNAKISPSKRQAREDVQNGAIYINGERVQDLDYTLSDTDKI
                     DNEITVIRRGKKKNFVLTY"
     CDS             complement(10001..11023)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_69"
                     /sec_met_domain="IlvN (E-value: 7.3e-77, bitscore: 248.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.1e-65, bitscore: 211.1,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQMEYEKDVKVPALDGKKIAVIGYGSQGHAHSQNLRDTGHDVI
                     IGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAV
                     GFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKD
                     IAMDWCKGIGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIETGFEVLTEAGYAPE
                     LAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEFGDYVSGPRVITEQVKENMKAVLAD
                     IQNGKFANDFVNDYKAGRPKLTAYREEAANLEIEKVGAELRKAMPFVGQNDDDAFKIYN
                     "
     CDS             complement(11099..11575)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_70"
                     /sec_met_domain="ALS_ss_C (E-value: 2.6e-28, bitscore:
                     90.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATENPDVSR
                     ITIIIDVNSHNEVEQIIKQLNRQIDVIRIRDITDVPHLEREVILVKVSAPTSKRAEILA
                     IIQPFRASVVDVAPSSITIQMTGDAEKSEALLRVIRPYGIKNIARTGATGFTRD"
     CDS             complement(11568..13268)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_71"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.8e-47, bitscore:
                     150.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VEKIELEEARSGADLILDTLLELGISTIFGYPGGAVLPLYDAIYK
                     NEEINHILSRHEQGSLHEAEGYAKSTGKLGVALVTSGPGATNAITGIADAMSDSVPLLV
                     FTGQVATSGIGKDAFQEADIVGITIPITKYNYQIRDTADIPRIIREAVHIATTGRPGPV
                     VIDLPKDVVAKETTFINDPEINLPSYQPTLRPNEMQINKILKQLGKAKKPVIVAGGGVA
                     YSESAKELVAFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSYAANIAMTDADFMI
                     AIGCRFDDRLTGNPKTFAKNAKVVHIDVDPAEIGKIIAVDLPVVGDAKQALEMLLAEPV
                     VKNNTEKWIEKVKKDKERVRSYDKKERMVQPQAVIERIGELTDGDAVVVTDVGQHQMWT
                     AQYYPYQNERQLVTSGGLGTMGFGVPAAIGAKIANPDKEVILFVGDGGFQMTNQELAIL
                     NIYKVSIKVVMLNNHSLGMVRQWQESFYEGRTSESVFNALPDFQLMAQAYGIKSYKFDN
                     PETIDQDLEVIKEDVPMFIEVDISRKEHVLPIVPAGKSNHEMLGVKFNA"
     CDS             complement(13402..15111)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_72"
                     /sec_met_domain="ILVD_EDD (E-value: 2.5e-221, bitscore:
                     727.9, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKVGVDKAPARGLLYATGQVKSSKDMQKPFIAICNSYIDIVPGH
                     VHLRELADIAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSRELIADAAETVIN
                     AHWFDGVFYIPNCDKITPGMILAAMRTNVPAVFCSGGPMKGGVDMTGHQATLSSLFEAV
                     GTYQSGDMSKEELDYLEKNACPTCGSCSGMFTANSMNCLMEVLGLALPGNGTILAVSDE
                     RRELVRQAATKLMDNIKNNVRPRDIVTKEAIDDAFALDMAMGGSTNTVLHTLAIAREAG
                     IDYDLKDINDIAKKTPYLSKIAPSSIYTMHDVHEAGGVPAIINQLIKKGAIKGDRITVT
                     GKTLKENVAGAKIKNEEIIHPIEQPILPVGGLSILYGNIAQDGAVIKVGGVDPSVKTFR
                     GKAICCDSQAQALELIDNGTVKKGHVVVIRYEGPQGGPGMPEMLAPTSKIVGRGLGKDV
                     SLITDGRFSGATRGIAIGHVSPEAAEGGNIALIEDGDEIVIDLPNRTLDLLVDDVTLEA
                     RRKHLNPFKSKISSGWLRRYTAFAKSANIGGTLMSNEEFEERKAERQAQEKN"
     CDS             15187..15309
                     /locus_tag="ctg1_73"
                     /transl_table=11
                     /translation="MNFRNISVIPKNDFLVSKLFKQKGSIISVVGKTTVEIIELF"
ORIGIN
        1 tttcttcaac acggtggtga gcagcatcga taatttcttg tttgttatca ataactggga
       61 tatcggcgat acccactgtc aatccagcaa gtgttgagta gtagtaacca aggtctttca
      121 aacggtcaag gaaagctgat gtttcagttg tacgaagacg tttgaagatt tcagcaatga
      181 tgttaccaag atgtttcttc ttgaatggcg cattaatttc caaactatcg ataactgttt
      241 ggatatcttg gcccggttca aggaagtatt tatctggtgt actatctgtc aagttctcat
      301 ttgttgtttc ttgaagatat ggaatttctg atggaatgat tgagttgaag agaatcttac
      361 caacagttgt tactaagatt ttgtgaagtt ggttttcttt ccaaggttta tcaggcatgc
      421 tatcgactgc aatacctaca cggctatgca agtgaacata accattatga taagccataa
      481 ctgcctcatc aatatccttg aagatcatac cttcaccttc acggccttca tcttccattg
      541 tcaagtaata gttaccaaga accatatcct gagatggtgt tacgactggt ttaccgtctt
      601 tagggttaag gatgtgttct gccgcaagaa ggagcaaacg tgcttcagct tgagcttctt
      661 cagacaatgg aacgtggatg gccatttggt caccgtcaaa gtcggcattg taggcctcac
      721 ataccaatgg gtgaagacga agagccttac catcaatcaa gacgggttca aaggcctgga
      781 tacccaaacg gtggagggta ggtgcgcggt taagaagcac tgggtgttcc ttgataacat
      841 cttcaagaat atcccaaata cgttcatcac cacgctcaac catacgttta gcagctttca
      901 cgttacctgc gtattcacgc gcaacgattt cacgcataac aaatggtttg aaaagttcga
      961 tggccatcaa acggggcaca ccacattgat acattttaag tgttggacca acggcaataa
     1021 cggaacggcc agagaagtcg acacgtttac caagcaagtt ttgacggaaa cgaccttgtt
     1081 tacctttaag catgtggctc aaagatttaa gtggacgact acctggtcca gtaattggac
     1141 gaccacgacg tccattatca ataagagcgt ctaccgcttc ttgcaacata cgtttttcgt
     1201 tttgcacgat gatacctgga gcacccaact caagcaaacg agccaaacgg ttgttacggt
     1261 tgataacacg acggtagagg tcgttcaagt cagatgctgc aaaacgtcca ccgtccaatt
     1321 gaaccatcgg acgaagatct ggtggcaata ctggcaatat gttaagcacc atccattctg
     1381 gtttattacc agacttgtaa aaggcgtcaa gaacgtccaa acgacgaact gctttaaaac
     1441 gtttttgacc agttgctgtc ttcaactctt ctttgagttc agcaatttcg gcttccaaat
     1501 ctacttgttt caagagatct tggatagctt ctgcacccat tttagcgaca aatgaaccat
     1561 gaccatactc ttgcaatttt tcacgatatt cacgttcagt caagagagat tttggctcaa
     1621 gcggtgtttc ctttggatcg ataaccacgt aagctgcgaa gtaaataact tcttcaagtg
     1681 cacgaggact catatccaaa gtcaatccca tacgagaagg gattcccttg aagtaccaga
     1741 tatgtgatac tggtgctttc aactcgatgt gacccatacg ttcgcgacga accttagcac
     1801 gtgttacttc aacaccacag cggtcacaaa cgatcccttt ataacggata cgtttgtatt
     1861 tcccacacgc acattcccag tctttagtag gaccaaagat cacttcgtcg aacagacctt
     1921 cacgttctgg tttgagcgta cggtagttga ttgtttcagg tttcttaacc tcaccataag
     1981 accatgaacg gaccttagtt ggtgaagcta gtgtaatttg catactttta aatcgattta
     2041 cgtcaaccac tagtattacc tttcttttgt tctattgaca atagcagcgc tattttcacc
     2101 tttatcagct accttagcag agaaatttaa ctccctctct aaagcttatt ttattctgtt
     2161 ttatctaaag cttcttcttt agctttttct aattcagcag cttctttggc ttgttgtaca
     2221 cgtgcttttt caagatcatc aacgtgcatg acgtcatcat cttcaccttc atcaagatca
     2281 cgcaattcaa cttcatagtc atcctcatca agaacacgca tatcaagacc aagtgattgc
     2341 aattctttaa cgagcactcg gaatgattct ggtacacctg gttttggaat tggttttcct
     2401 ttagtgatag cttcataggc tttcaaacgt ccgttaacgt catctgactt gtaagtcaag
     2461 atttcttgaa gaatgtttga agcaccgtaa gcttcaagag cccaaacctc catctcaccg
     2521 aaacgttgtc caccaaattg tgctttacca ccaagaggtt gttgggtaac gagtgagtaa
     2581 ggacctaccg aacgagcgtg aagtttatca tcaaccatgt ggtgaagttt gatcatgtac
     2641 atgacaccaa ctgacacacg gttatcaaat ggctctcctg tacgtccatc gtaaaggatt
     2701 gtcttagcat cactatccat accagcttca cgaacagtat cccagagatc ttctgagctt
     2761 gccccatcaa agactggtgt tgcgatgtag atacccaagt tacgagcagc cataccaagg
     2821 tgaagttcca taacctgacc aatattcata cgtgatggta ccccaagagg gttcaacatg
     2881 atgtcaactg gtgtaccgtc tggaaggtaa ggcatgtctt caacaggaac aatacgagaa
     2941 acaacccctt tgttaccgtg acgaccagcc atcttatctc cgaccttgat tttacgtttt
     3001 tgagcgatgt aaacacgaac aagcatgtta acacctgatt gcaattcatc accgtttgca
     3061 cgtgtaaaga ttttaacatc acgaacgaca ccatcaccac catgaggtac acggagtgat
     3121 gtatcacgta cttcacgaga tttatcacca aagatagcat ggagaagacg ttcttcagca
     3181 gaaaggtctt tttcaccctt aggtgttacc ttaccaacaa gaatatcacc ttctttaacc
     3241 tcagcaccga tacggataat acccatttcg tcaaggtttt taagggcttc ttcactaacg
     3301 tttggcaatt cacgtgtgat ttcttcaggt ccaagctttg tatcacgtgt ttctgattcg
     3361 aattcttcca agtgaacaga tgtataaaca tcgtctttca ctaggcgttc actcatgata
     3421 acagcatcct cgaagttgta accttcccat gtcatgtatg cgacaatagg gttttgaccg
     3481 agggccattt ctccaccttc catagatgga ccatcagcga taaaatctcc tttttcgaca
     3541 atatcaccaa ccttaaccaa agtacgttgg ttatacgcag tacctgagtt tgaacgacgg
     3601 aatttttgaa tagtatagac gtcaagagaa ccatcttcac gacgaacttc aaccttatcg
     3661 gcatcagaat agacaacttt accatcatgt ttagcgataa ctgcagcacc tgaatcgtgg
     3721 gcagcttgat attccatacc agtaccaaca aatggtgctt ttggatcaat caatggcaca
     3781 gcttgacgtt gcatgttggc acccatgagg gcacggttag agtcatcgtt ttccaagaaa
     3841 ggaatacatg ctgtcgcaac ggcaactacc tgtttaggag aaacatccac gaaatctaca
     3901 aggtgtgatg ggtactcttg gttaacacct tggtgacgac ccatgacaat ttcttctgca
     3961 aatgttccat cttcgttcaa tttagagtta gcctgagcaa ctatgtactc atcttcttcg
     4021 tcggcagtca accaaaccac ttcgtttgtt actttaccag ttgcacggtc aaccttacga
     4081 tatggtgttt gaatgaaacc gtacttgtta aggcgtccgt atgtagacaa gttattgatc
     4141 aaaccaatgt taggtccttc aggtgtttca attggacaca tacgaccgta gtgcgtgtaa
     4201 tgcacgtcac gaacttcata tccggcacgg tcacgtgtca aaccaccagg tcccaaggct
     4261 gacaaacgac gtttgtgtga caactctgac aatgggttgt gctggtccat gaactgtgac
     4321 aactgtgaag aaccgaagaa ttctttaaca gctgcagtta caggacgaat attgatgatt
     4381 tgttgtggtg tcaaggcttc attatcttga actgacatac gttcacgcac gtttcgttcc
     4441 atacgagcca aaccaatacg gaattggtta gcaagcaatt caccaacggc acggatacga
     4501 cggttaccaa ggtggtcgat atcatctact ttaccgatac cttcagcaag gttgaggaag
     4561 tagctcattt cagccaagat atccgctgtt gtcaaagcac gaactttatc atctggattg
     4621 gcattaccaa caattgtaac cacacgatct ggatcatttg gtgcaacgac cttgaatttt
     4681 tgaagaacaa caggttctgt aaccactgca taatcgtttg gtgtgtatac aaatttgttc
     4741 aaatcaccgt ccaagtgttc tgcgattgaa tcaatcacat cacgtgtcat ttcagtccca
     4801 gcttcaacaa ggatttcacc tgtttcagga tctaccaagt tttcagcaat tgtttgtccc
     4861 aaaagacgtg tcttgatgtt aagttttttg ttaagtttgt aacgaccaac agcagccaag
     4921 tcgtaacgac gtggatcaaa gaaacgagct acaagcaagc tacgtgagct gtcagcagtt
     4981 tttggttcac ctggacgaag tctttcataa atttctttaa gcgcttcatc agtacgtgaa
     5041 tctgctggat ttttgtggat atctttttca atagtgttac gaaccaactc gctatcacca
     5101 aagatatcaa caatttcgtc atcacctgag aatccaagtg cacgcacaag cgttgtaaat
     5161 ggaatcttac gcgtacggtc gatacgagtg taggcgatgt cttttgaatc agtttcaagc
     5221 tcaagccatg ccccacggtt aggaataact gttgatccgt aacccacttt accgttttta
     5281 tcgaccttat cgttaaagta aacaccaggt gagcgcacca actgagaaac gataatacgt
     5341 tcaccaccat tgatgataaa agtacccatc tcagtcataa ttgggaaatc tccgaagaag
     5401 acttcctgag ttttaatttc accagtttct ttgttaataa gacggaaagt cacaaagatt
     5461 ggtgctgagt atgatgcatc atggatacga gcttcttcaa gtgtatactt aggttccttc
     5521 aattcgtaac caacaaattc caattccatg gtgtctgtga agtttgaaat aggaagtaca
     5581 tcctcaaaaa cctctttaag accagtatct aagaattctt tgaatgaatc cgtttggatt
     5641 tcaatcaagt ttggtaaacc aagaacttct ttgattcttg aaaaactacg acgggtacga
     5701 tgcttcccgt attgaacgtc atgtcctgcc aagtcttcta ctccttttct acatttgaga
     5761 cctgctttgc aagtcgtgca ctttaaatat ttgtctcctg ccttttttgg ttgcttgtcc
     5821 cgataacaag tgattagata ttaacatcga cttatcggat taacgataag cgataacttt
     5881 aatatgtgaa tttttagaac ttttaaatat tcattacaaa atccaaaaac cctaaaaata
     5941 agcacaaaaa tagcagctaa atctgaccga aaaaacgttg atttaactgc tgtatctctt
     6001 gattggacaa tatttcaatc aaataagacg acaaatagtt ttgtctatat tgtacctaaa
     6061 ttttaactat tttgcaagta ttatttgaga cagcctaatg ttctccaaga atactagacc
     6121 aagctttttg gtagtcacta tccgttccac caatggcaaa cttgtagatt gtatcgccag
     6181 gtccattttt agcccaataa ctatcaacca tttcaccact tacggagaca ttacggccat
     6241 tgaccgatac cgttgctggc ttaaggcctg tcgacttgag cacacttgcc ttaatggcgc
     6301 ttgaatctat attaaactta tctcccgttt tgaaaatacc tggattagca ttatagatgg
     6361 ctgaagtcaa acgagccata tattgggcat tgtaagtgta acccatttta gaattggtag
     6421 gtgcattgtc atcataacca gcccaacccc caagggtaat gccaggcgtc gacacaacca
     6481 accaagcatc agcaaagtta tcagttgtcc ctgttttacc catccagtca gctgaggccg
     6541 ctgcaccatt gacatttttc aactccgaat aaaattgggt tgtcgctccc ttaaccacaa
     6601 cttctttaag taagttatcc ataatgctag ccgtagccct tgtaaagacc tgaacccctt
     6661 tagatttatg ttgataaata acctcaccag tgctatcagt aatactatca atcatataac
     6721 ctttttcata aacaccgcca tttgaaagca tttgataggc gtttacctgc tgagcaacag
     6781 tagtttcaat cccaccacca aggggcagac tctcaatatt gtagttagca atcttatatc
     6841 ccatcttggt catatagccc tcaacgtcaa catcatgatg ttgaagcatt tgataggtcc
     6901 aaaaggcagg aatattccac gacgtattaa gcgcctcttg caaattcatc atggccgttc
     6961 ccttatcgcc atcatgaaga atcggtgtcc cacctgtaaa attagttgga taatttgaaa
     7021 ggatacttga gctacccatt aaaccttggt caatggcaat tccataagca ataataggct
     7081 taatagaaga tccaggagaa cgagcagtat caaaggcatg gttattctgg ttattctcat
     7141 aattacgacc accaacaaat cctaaaatcg ctccagtcgc attgtccatg agtacatttc
     7201 caacttcgac cccgttattt ccaccctgat caagtagatc tccatatttg ttcgcagtat
     7261 cttgcatcgc atggtagaca gcattgtcaa ttgttgtctt aacatgataa ccacctgttt
     7321 gtagctctcg gagagccatc tcacggtagg cttcctttgt cttatcattt ttcaaatctt
     7381 gacttgatac cttgtcacgc ttcaccaaat aatcatacat gatatcttga gcttcagaca
     7441 tgactgaata gtacaaatag tcatgactga cagcatctgg attctcacca gccttgaaat
     7501 ctttagtaac gtcataactc ttataacttt cgtattgtga cttatctagg taaccgcctc
     7561 gatagagatt gtagagcaca tctttctgac gtgccaagcc ataggaaaga tctttttcat
     7621 tttttagttg accatccgca gtatagggtg aatagacaat cgggctctgt ggtaaacctg
     7681 ccagataagc tgcctgagga actgtcaaat ctgcagcaga gaccccaaag atcccttgtg
     7741 cagcctcttc gataccagca atatttttcc ccttgttgtt acgaccaaaa ggagaaacat
     7801 tcagataatc agttaaaatt tcatttttcg aagcatgacg ttccagttgt agtgcataga
     7861 taatctctgc cgctttacgt ttaaatgttg gagtatctcc tgtaacctgt tgttttatca
     7921 actgctgtgt tagggttgaa ccaccactag aggaacctac ccccaagact gaggatacca
     7981 aggctctaaa gacagctttt ggtacaaccc ccttatgctt attgaaattt tcatcctcag
     8041 tagcaataat ggcattttta acattattag aaattgcatc actttcaata ggagttctaa
     8101 gcaggtccgt atcaatatca gcaatctttt tagaatcaga ataactcatc gaagacacca
     8161 aactaacctc gccaatctga ttcaacaagg ttttatcctt aatcaatgga acagactgta
     8221 tctgactgcc cagataaccc aaaccaattc ctgcaccaaa tagggtaaga acgataataa
     8281 ccacataaaa gaaatcagac aagagcttta aggtttttaa gaaaacatca cccatgtcta
     8341 agagtgtcat cccatcctca ggcgacttcc gtgcttgctt acgattccac ttgaatccag
     8401 tcgtagcttt cctttcttta aaagatttat ctcctctttt agacctagaa ccagcaaact
     8461 ttgtacgaat agtctgccct agtcgcctaa aataatttat tattttttca aaattcatag
     8521 aaatacctca aagcctatta taacaaactt tgacaaagct tgcatagggt tgcttctttt
     8581 ggtataatgg tgcagaatat actttactgg agaatatcat gacaattttt gaagaactaa
     8641 aagcacgtgg cttgattttt caaaccacag atgaagaagc ccttgtaaaa gcctttgaag
     8701 aagggccagt ctcattctac actggttatg atccaacagc agacagtctc caccttggac
     8761 acctcgtcgc tatccttact agtcgtcgcc ttcaattggc tggccacaaa ccttacgccc
     8821 tcgttggggg tgcgacaggt ttgattggtg acccatcatt taatgatgct gagcgtagcc
     8881 tccaaaccaa agaaaccgtt gaaggttggg tagaaaaaat ccaaggacaa ctctctcgtt
     8941 tccttgattt tgaaaatggt gacaacaaag ccgttatggt caacaattat gactggtttg
     9001 gttctgtcag cttcatcgat ttcttgcgtg atgtcggtaa atacttcaca gttaactaca
     9061 tgatgagcaa ggaatctgtt aagaaacgta tcgaaacagg tatctcttac actgagttcg
     9121 cttaccaaat tatgcaaggt tatgacttct atgaactcaa tgctaaatat ggcgtaaccc
     9181 tacaaattgg tggttctgac caatggggta acatgacagc aggtactgag ctcttgcgtc
     9241 gtaaagcgga taaatctgga cacgtaatca cagttccact tatcacagat tcaactggta
     9301 aaaaattcgg caaatctgaa ggcaacgctg tctggcttga cgctactaag acaactcctt
     9361 atgaaatgta ccaattctgg cttaacgtta tggacgatga tgccgttcgt ttcttgaaaa
     9421 ttttcacttt cttgtcactt gaagaaatcg aagaaatcgg taaagaattt gaccaagctc
     9481 gtcaccaacg tttagcacaa aaggttctgg ctcgcgaagt tgttactttg gttcacggta
     9541 aagaagccta tgaacaagct gttcacatca ccgaacaact cttcgctggt aaccttaaag
     9601 ccctctcagc acgtgacctt aaagttgccc tcaatggtgt cccaacctat gagatttcag
     9661 cagatgaaaa tcttaacatt gttgaacttc tcgtcaatgc taaaatttca ccatctaaac
     9721 gtcaagcacg tgaagacgtg caaaacggtg ctatctatat caacggtgaa cgcgtgcaag
     9781 acttggatta cactctttca gataccgata agattgacaa tgaaatcact gttatccgtc
     9841 gcggtaagaa gaaaaacttt gttttaactt actaatttat gaccattctc actccctagt
     9901 ggagtgattt tttttacaca caaagccata agcttaacac ctaatcactt tcttaagaac
     9961 acaaaaaacc agcactaggc tggtttttga gactatcaca ttagttatag attttgaatg
    10021 catcatcgtc gttttgacca acgaatggca ttgctttacg caattcagca ccaacttttt
    10081 cgatttcaag gttagcagct tcttcacggt aagcagtaag ttttggacgt ccagctttgt
    10141 agtcgttaac gaagtcatta gcgaatttac cattttggat atcagcaaga actgctttca
    10201 tgttttcttt aacttgttca gtgataacac gtggacctga tacatagtca ccgaattcag
    10261 cagtgttaga aattgattga cgcattttct tgaatccacc ttcgtaaatc aagtcaacga
    10321 ttaatttcat ttcgtgaagt acttcaaagt aagccaattc tggtgcatat ccagcttcag
    10381 tcaagacttc aaaaccagtt tcgataaggg cagtcaaacc accacaaaga actgcttgtt
    10441 caccaaacaa atcttcttca gtttcttctt tgtatgttgt ttcaagaaga cctacacgtg
    10501 ctgcaccaat acctttacac cagtccatag cgatgtcttt agcgttacct gtggcatctt
    10561 ggtatactgc gtaaagggca ggtacaccaa aaccttcttc aaatgtacga cgtaccaagt
    10621 gacctggtcc tttaggtgca cacataaata catcaacatc tgctggtact ttaataaatt
    10681 caaagtggat gttgaaaccg tgagcaaaac caacagcgtt accagcttca agatttggag
    10741 cgatttctgc ttcgtaaagt tcttgttgga tttcgtctgg agccaaaatc atgataacat
    10801 cagccaattt agttgcttct gctactgtgt aagtatcaaa accatcttct ttagctttat
    10861 caaatgattt acctggacga acaccgatga taacatcgtg acctgtatca cgcaagtttt
    10921 gtgagtgagc gtgaccttgt gaaccgtaac cgataacggc gattttttta ccatcaagtg
    10981 ctggtacttt tacgtctttt tcatattcca tttgaactgc catagtagta tatctctttt
    11041 ctaaaataat atttaattgc ctttttaagg ctaggttaac aaatttataa tggatttttt
    11101 aatcacgggt aaatccagta gcacccgtac gagcaatatt cttgataccg taaggtcgaa
    11161 taactcgtag aagcgcctca ctcttttcag catctccagt catctggata gtgatagagc
    11221 ttggtgcaac atccaccacc gaagcacgga aaggttgaat gattgccaag atttcagcac
    11281 gtttagaagt tggtgccgac accttaacca agataacctc acgttccaag tggggtacat
    11341 cagtgatgtc acgaatgcga atcacatcaa tctgacgatt aagctgttta ataatctgct
    11401 caacctcatt atgagaattc acatcaatga taattgtaat acgtgaaaca tcaggatttt
    11461 ccgttgctcc aacggaaata ctctcaatat tgacctgacg gcgtgaaagc actccagtga
    11521 aacggttaag aacacctgat cggttctgaa gtttagctgt taacattcta cgcattgaac
    11581 ttcaccccca acatttcatg attactctta ccagctggaa caattggcaa aacatgctct
    11641 ttacgagaaa tatcaacctc gatgaacatt ggcacatcct ctttgataac ttccaaatcc
    11701 tgatcaatcg tttctggatt atcaaactta taagacttaa tcccataagc ttgagccatc
    11761 agttgaaaat cagggagagc attaaagaca gactctgatg tacgcccttc gtagaaggac
    11821 tcttgccatt gacgtaccat accaagtgag tggttattca acataacaac cttgattgac
    11881 accttgtaaa tatttaaaat agccaattct tggttcgtca tttggaaacc accatcacca
    11941 acaaagagga taacttcttt atcaggatta gcaattttag caccaattgc tgctggaaca
    12001 ccaaatccca tagttccaag gccacctgat gtcaccaatt gacgctcatt ttgatatgga
    12061 taatactgag ctgtccacat ttgatgttgc ccaacgtcag tgacaacaac tgcatcacca
    12121 tcggtcaatt caccgatacg ctcgataacc gcctgaggct gtaccatacg ttctttctta
    12181 tcgtaagaac gtacacgctc tttatctttt ttgacttttt caatccattt ttcagtgtta
    12241 ttcttaacca ctggttctgc taagagcatt tcaagagctt gcttggcatc accaacaact
    12301 ggcaaatcta ccgcaataat cttgccaatc tcagccggat ccacatcaat atgaacaacc
    12361 tttgcattct tagcaaatgt ttttggatta cctgtcaagc ggtcatcaaa acgacaacct
    12421 atggcaatca taaagtcagc atcagtcata gcaatattag ctgcatacga accgtgcata
    12481 ccacccatac ccaaaaagag gggatgacta gtagcaattg ttccctgacc tagaagactt
    12541 gtaacaacag gaatttggta gcgttctgca aaagcaacta gctccttagc agattcagaa
    12601 taagccactc cacctccagc tacaataacc ggcttcttag ctttacccaa ctgtttcaag
    12661 attttattaa tttgcatctc gtttggtctt agcgtcggtt ggtaacttgg aagattgatt
    12721 tcaggatcgt tgatgaaggt agtttcctta gctacaacat cttttggaag gtctataaca
    12781 accggaccag gacgtcctgt cgttgcgata tgaaccgctt ctcgaataat acgaggaata
    12841 tcagccgtat cacgaatctg gtagttgtat ttggtaattg gaatggtaat tccgacaatg
    12901 tcagcttctt ggaaggcatc cttaccaata cctgatgttg ctacctgacc cgtaaagacc
    12961 agaagaggta cactatcact catagcatct gcaatcccag taatagcatt cgttgcaccg
    13021 ggaccactcg ttacaagagc aacaccaagt ttcccagttg atttagcata accttcagct
    13081 tcatgcaggc ttccttgctc atgacgagac aaaatatgat taatctcttc atttttgtaa
    13141 atagcatcat acaaaggaag aaccgctccg ccaggatacc caaaaatggt tgaaatccca
    13201 agttcgagaa gtgtatcaag aatcaaatca gcaccagagc gtgcttcttc aagttcaatt
    13261 ttctccacat ggacctcctt tagcaattgt ttttttcaaa ttatctaaaa attcaaaacc
    13321 ttgtatacta tactaacatt tttaactaaa tttgcaaggg tttcagagaa aaatatcaca
    13381 aactcttcgg aaataatatt cttagttttt ttcttgtgcc tgacgttctg ctttacgttc
    13441 ttcaaattct tcattactca taagagttcc tccgatatta gctgatttag caaaagcagt
    13501 gtaacggcgt aaccagccac ttgagatctt agatttgaaa gggttcaagt gcttacggcg
    13561 tgcttcaagt gtcacatcat caacgagcaa atcaagggta cgattcggaa gatcaatcac
    13621 aatttcatcc ccatcttcaa tcagagctat attgccacct tccgcagctt ctggagatac
    13681 gtgaccaata gcaataccac gagttgctcc tgagaaacga ccatcagtaa tcagagaaac
    13741 atccttgcca agaccgcggc ctacaatctt agaggttggc gctaacatct ctggcatacc
    13801 aggaccaccc tgaggaccct cgtaacgaat gacaacaaca tggcccttct taactgttcc
    13861 attatcaatc aattcaagag cttgagcttg tgaatcgcaa caaatagcct taccacggaa
    13921 agttttaacg gatggatcta caccaccaac cttgataaca gccccatcct gagcaatatt
    13981 tccataaagg atagacaaac cgccaaccgg taaaataggt tgctcgattg gatggataat
    14041 ttcttcattt ttgattttag caccagctac attttctttt aaggttttac cagtaaccgt
    14101 aatacgatca cccttaatgg cacctttctt gatcaactga ttaataatgg ctggaacacc
    14161 acctgcttca tgtacatcat gcatggtata gatgctggag ggagcaattt tagagagata
    14221 aggtgtcttc ttagcaatat cattaatgtc cttaaggtca tagtcaatac cagcctcacg
    14281 cgcaatagca agggtatgaa gaacggtatt ggttgaacca cccatagcca tatctagagc
    14341 aaaagcatca tcgatggctt ctttggtcac aatatcacgt gggcgaacat tatttttgat
    14401 gttatccatt aattttgtgg ctgcttgacg aaccaattca cgacgttcgt ctgaaacagc
    14461 taggatagta ccgttacctg gaagggcaag acccaaaact tccattaaac agttcattga
    14521 gttagcagta aacattcctg aacatgaacc acaagttgga caggcatttt tctctaaata
    14581 atcaagctct tccttgctca tatctccaga ctggtaagta cctacagctt caaacaagct
    14641 tgataaagta gcctgatgac cagtcatatc aacgccaccc ttcataggtc cacctgaaca
    14701 gaataccgcc ggcacattag tacgcatggc tgccaaaatc attcctggtg taatcttatc
    14761 acagtttggg atatagaaca caccgtcaaa ccagtgggca ttaataacgg tttctgcagc
    14821 atcagcaatt aattctcgtg aagggaggct gtaacgcatc ccaatatgtc ccatggcaat
    14881 cccgtcatcc acaccaatag tattaaactc aaaaggaata ccaccagctt cacggatagc
    14941 ctccttggca atatccgcta attcacgtag gtggacatgt cctggaacaa tatcaatata
    15001 agaattacaa atagcaataa agggcttttg catatcctta gaagatttaa cctgtccagt
    15061 cgcatacaaa aggccacgtg ctggtgcttt atcaacacca actttgatca tatcacttct
    15121 catgatctta ccttcaatct ataaaatttc ttacaacata tgttaccact ttggaaggta
    15181 atgtcaatga attttcggaa tatttctgta attccaaaaa atgacttttt agtatcgaaa
    15241 ctatttaaac aaaaaggctc tataatttct gtagtgggta aaactactgt agagattata
    15301 gagctttttg
//
