LOCUS       c00037_JAIQWL0..       14109 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWL010000004.1 Streptococcus thermophilus strain CF10_14
            NODE_4_length_100851_cov_36.188678, whole genome shotgun sequence.
ACCESSION   JAIQWL010000004
VERSION     JAIQWL010000004
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:17:05
            Original ID  :: JAIQWL010000004.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 86742
            Orig. end    :: 100851
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14109
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[91742:100687]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..13945
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14109
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14109
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             31..237
                     /locus_tag="ctg37_83"
                     /transl_table=11
                     /translation="MRERGQVWSYSEVKRESQLANYNTDGRYLSETTNFELYNFVREYK
                     TSDEIRRIWNPKKDESVIHDKDN"
     CDS             552..2183
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 367.6; E-value:
                     1.9e-111)"
                     /gene_kind="transport"
                     /locus_tag="ctg37_84"
                     /transl_table=11
                     /translation="MGRVIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILA
                     TSYRLGQIMRSRLFEHFTKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDAS
                     ITALVTLITMFFSISWQMTLVAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQ
                     ESVSGIKVTKSFGYQEAELQSFQETNKMTFEKNMHTMKYDSLFDPLVLLFVGSSYVLTL
                     LVGAFMIQAGQITVGNLVTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIETLLEQES
                     DVQDPAYPLPSIENGRLDFAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGPTGSGKTALV
                     KLLLREHDVNQGAIYLNGHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNIRFGNPDFS
                     IDKVEEATKLAQVYDDIKDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILD
                     DSLSAVDAKTEHAIIDNLKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHDD
                     LLAQGGWYAKTYESQQLEMEGGEAHA"
     CDS             2176..3921
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     284; E-value: 1.5e-86)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 314.5; E-value:
                     2.4e-95)"
                     /gene_kind="transport"
                     /locus_tag="ctg37_85"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGILSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVVIIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNI
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLI
                     DGVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKIRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     TMEGE"
     CDS             5001..7154
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 305.5; E-value:
                     1.2e-92)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_86"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1100.4,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.6e-45, bitscore:
                     145.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMM
                     TFARDYLLTILSHRFTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALAS
                     TILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSN
                     AMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQ
                     LILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRL
                     NEVYLIESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVG
                     VSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLE
                     NLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARAL
                     LTKSPVLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGR
                     VVETGSHQDLMSYPGFYYQLFRK"
     CDS             7170..8537
                     /locus_tag="ctg37_87"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEGLQK
                     QLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKTNTE
                     VNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQ
                     YATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQF
                     LQNAGQQLSSVETQINDTESKINQADVLLTNTLIQSPEDGILHLSQADKKATMAATGTE
                     LAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSA
                     TETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ"
     CDS             8552..8713
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_88"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.6e-08,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQA"
     CDS             complement(8731..10071)
                     /locus_tag="ctg37_89"
                     /transl_table=11
                     /translation="MLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLAF
                     NFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLITF
                     FIFPFFNISITDYKSSLLISIPSSIAPLCLSFLFIKLFKESFTILQKQKSNSPIQHIII
                     VANFFMFGYTLLLQSLMYLENTTHSSTLELRKLCIVISLVLFFIMIVFLERNIREMIQG
                     QLDFQKNLQLENLYTYNKHIECLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEVYDS
                     VLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGME
                     TLDFIIVTSIFLDNAIEGAIQTQNPKITISFWEDHCSQLLSISNTISEEKTETKTIFER
                     GVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     CDS             complement(10065..10802)
                     /locus_tag="ctg37_90"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEDAVAHELMTFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIIRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGETIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNLTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGRGC"
     CDS             11053..11229
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_91"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.4e-11,
                     bitscore: 37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGLSCDEGMLAVGGLGAVGGPWGA
                     VGGVLVGAALYCF"
     CDS             11248..11448
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_92"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 9.7e-09,
                     bitscore: 28.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNKQLERFKKLDTNALSNVSGQGYGAQCVIGTTGMTIVGAAFFG
                     IAGAGAGFAGGSTAFCYDTAK"
     CDS             11804..12034
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_93"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 9.1e-19,
                     bitscore: 60.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGVCSWGGFAKQGVATGVGNGLRL
                     GIKTRTWQGAVAGAAGGAIVGGVGYGATCWW"
     CDS             12230..12445
                     /locus_tag="ctg37_94"
                     /transl_table=11
                     /translation="MIENFDIREELFVIMTKKRLVSLMMSMGFVLVALHNFGEKLNFGL
                     QCLNLIGLCLFLFLMCTVIKDIRSDK"
     CDS             12542..12709
                     /locus_tag="ctg37_95"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIVMGLANLFRSLDAVHHTINLLGLTVLLYSL
                     LFKKWVQFQK"
     CDS             13039..13440
                     /locus_tag="ctg37_96"
                     /transl_table=11
                     /translation="MKLKNISSSVLRSFRTITAALAVFLISISLSLYKSKISPGTWLTV
                     GALAFVVIFVNGLLYRMLKKRPDSVNLLTIRQSFIVFPVITFLVLSVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLSYLQVKKYFKQ"
     CDS             13691..13945
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_97"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2e-14, bitscore:
                     46.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENLNTLDLETLASVEGGGCSWGGAGGATVQGAIGGAIGG
                     AFGGNVVLPVVGSVPGYLAGGVLGGAGGTVAYGATCWWS"
ORIGIN
        1 cttatcaaaa gtggccgtga tgccgatatt atgcgagaaa gagggcaggt ttggagctat
       61 tctgaggtta agagagagtc tcaattagct aactacaaca ctgatggtcg ctatctcagt
      121 gagacaacta acttcgaatt gtacaatttt gtcagagagt ataagacatc tgatgaaatc
      181 agacgtattt ggaaccctaa gaaggacgaa tcagttatcc acgataagga taactgattc
      241 tattgatgat gggcacaagg tctataattt tgactccttt gcttatcaat tgccagagtc
      301 tactgatttt ggaaaattga cttatattgg tcactttcag ttagaagatg gtacaattta
      361 tcgctattgg aaataacttt cattagactt ataatcatcc ttttgtaggg atagggggaa
      421 taacttgttt ttttaaagaa tcaatcattg caaaactttg gtggtttttc aagttagaaa
      481 aacgccgtta tattgtcggg atattggcac tgagtttggt ttcggttctc aatctgattc
      541 ctcctatggt tatgggtcgg gtcattgatg ctatcacatc gggaaaattg accaatcaga
      601 tcttgctttt gaatctcgtt tatttgcttt tggcggcttt aggaatgtac tatttgcgct
      661 atgtttggcg gatgtatatc ttggcaacgt cttatcgctt gggacagatt atgcgttcgc
      721 ggctttttga gcattttacc aagatgtcgc cttcttttta ccaaaagtac cgaactggtg
      781 atctcatggc ccatgccacc aatgatatca actctctaac ccgtttggct ggtgggggtg
      841 tcatgtcagc cgtggatgcg tctatcacag ccttggtgac tttaatcacc atgttcttca
      901 gcatttcctg gcagatgacc ctggtggcag tcttacctct acctttcatg gcttttgcga
      961 ctagtcgttt gggacgtaag acccacaaag cttttggaga atcccaggca gctttttctg
     1021 aacttaataa taaggtacaa gaatcggtgt caggtatcaa ggtaaccaag tcttttggct
     1081 atcaggaggc tgagctccag tccttccaag agaccaataa gatgactttt gaaaagaata
     1141 tgcataccat gaagtatgac agcctttttg atcccttggt tttgctcttt gttggctcat
     1201 cttatgtttt gaccctcctt gtcggggcct ttatgattca ggccggtcag ataacggtcg
     1261 gaaatttggt aacctttatt acctatttgg acatgctggt ttggccccta atggccattg
     1321 gcttcctctt taatatcacg cagaggggaa atgtgtccta ccaacgtatc gagactcttt
     1381 tagagcagga atcagatgtt caagatcccg cttatcctct tccaagcatt gaaaatggtc
     1441 gtttagactt tgcgattgac cgctttgctt ttgaggatga ggatactttg cgagatattc
     1501 atttcacctt ggacaagggg caaacccttg gtttggttgg accgactggc tcaggaaaga
     1561 cggctcttgt caagttgctc ttgcgggagc acgatgtcaa tcaaggagcc atctatttga
     1621 atggacatga catccgagac tatcgcctat cagacttgcg tagcttgatt ggttatgttc
     1681 ctcaagacca gtttctcttt gccagttcta ttttagacaa tatccgcttt ggtaatccag
     1741 atttctccat tgataaggtg gaagaagcga ctaagttagc tcaagtttat gatgatatca
     1801 aggatatgcc tgaaggcttt gaaacaatca ttggtgaaaa gggtgtcagc ctatcaggtg
     1861 gtcaaaaaca acgtctggct atgagccggg ccatgatttt gaatccagaa attttgattt
     1921 tggatgactc cttatctgcg gttgatgcta agacagaaca tgccattatt gataatctta
     1981 agcatactcg caaggacaaa acaactatta ttaccgccca ccgtctcagt gcggtggtgc
     2041 acgctgacct catcctggtc atgcaagatg gtcgtatcat tgaacgtggg cgtcatgacg
     2101 acttactagc tcaaggtggt tggtatgcca agacctatga gtctcaacag ttagaaatgg
     2161 aaggaggaga agctcatgcc taatcaaaac caatggtctg tgtttaagcg tctcttgacc
     2221 tatctcaagc cttacaagtt cttgaccttt ctagctttga ccttcctctt gtccacaacg
     2281 gttatcaaga gtatcattcc cttggtggcc tcttatttta ttgatcacta tcttcatgat
     2341 atgaatcagg cggcaagtat gattctgatt ggctactatg gtctctacct cttgcagaca
     2401 ctagtccagt atctgggaaa tctcttcttt gcgcgtgtgt cctatagcat tgtcagagat
     2461 attcgtcgag atgcctttgc caatatggaa aaactgggta tgtcttactt tgacaagacc
     2521 ccagcaggtt ccatcgtttc ccgcttgacc aatgatactg agaccattag cgagatgttc
     2581 tcaggaattc tgtctagttt tatttcggct atctttatct ttgttaccac cctttacacc
     2641 atgatgatct tggacattcg tctgaccggg cttattgtcc tctttcttcc tctgattgtc
     2701 cttttggtta acctttatcg caaaaaatca gtggtcatca ttgaaaagac cagagccttg
     2761 ctttcagata taaatgccaa actgtcagag agtatcgaag ggattcacat cattcaggcc
     2821 tttaaccagg agaagcgtct taaaaaagag tttgatgcca ttaatgagga acacctgatt
     2881 tatgccagcc gttctatatc actggattct ctctttctac gcccagccat gagtctactg
     2941 aagctcctgg cttatgctgt tctcatggcc tattttggct accgaggtat ctatctgggt
     3001 atcacagcag gtaccatgta tgcctttatc cagtatatta atcgcctctt tgatcccttg
     3061 attgaagtga cacaaaactt ctcgactcta caaacctcta tggtctcagc aggtcgggtc
     3121 tttgccttga ttgacgagcg tacctatgag cctgaacaga gagacacagc tgccaaggtt
     3181 actgagggga atattcgctt tgagaatgtc tccttctcct atgatggcaa gcaccagatt
     3241 ttggataata tttccttctc tgtcaataaa ggtgaaacca tcgcctttgt gggatctaca
     3301 ggctctggaa aatcctctat tatcaacgtg ctcatgcgat tctatgaatt ccaatcagga
     3361 cgagttctca tagacggtgt ggatattcgt gattatagtc aggcagagct gcgcaagaat
     3421 attggtcttg tccttcagga ccccttcctc tatcatggca caatcaaatc caatattgcc
     3481 atgtatcaag atttaactga tgaagagatt aaagctgctg ctgagtttgt cgatgccaat
     3541 cactttattg ataaacttcc tgaaggctat gattccccag tttccgaacg tggttcaagt
     3601 ttctcaaccg gtcaacgcca gcttctagcc tttgctagaa ccgttgctag ccagcctaaa
     3661 atcttgattt tggatgaagc gacagccaat attgattcgg agacagaggc tattgttcaa
     3721 aactctcttg caaaaattcg tcaaggccgt acaaccattg ccattgccca ccgcctatca
     3781 acaatccaag atgctaactg catctatgtc ttagacaagg gccgcatcat tgaacacggt
     3841 agccacgaag agctcctagc cctcggcggc acctatcaca agatgtacag cctacaagca
     3901 ggcaccatgg aaggagagta agctaatcta gaccatagct tctatattcg aaaagatttc
     3961 ttaaaaatca aaatcgagta gcgacattta tgtcactact tttttgttgg ctaccaccct
     4021 ataataaaat catagcttga gagaaaaagc taaaaataat ttaggaggtt gttagaatga
     4081 caaggcaaac aaataataca tttgaaacac tcgatctcga ggtacttgca aacgttgagg
     4141 tagtgtaaaa taagttgtgt aaacacaaaa aggaataaat ccgttatagt agagttgcaa
     4201 aacattacta gaaagagatt tattcctatg actcagttta ccacagaact acttaacttc
     4261 ggctctataa tttctgtagt gggaaaaacc actgtagaga ttatagagct ttttgagatg
     4321 gtgccacctc aaggttgagt aaatcaaaag atagaaggca caattactca aggtggaaat
     4381 aaggtgggca ttaaggaagg gaacccctct agtgacgcta aaaatagcat tgacagtgat
     4441 aacaaataca cttacaaagc taaggaaaat taaaccgata attgagtaat cgaatctcaa
     4501 gaggctgatt tagccttttt tgataggatt ttttgagata tggattgacg tttttcataa
     4561 tgttatccct tttcggaata aaaataatca aattatgaca tcatacgata gagataggct
     4621 ccgaggctat cagcagtcat ggtttccttt ggaaatacca gggctggcac agtaataatg
     4681 gttagatcaa atacgtatgc ttgtaggact attttagaat gtttccttct aataactatt
     4741 gtataacttt gaaatcgatt tcaatgaact tgtcctaaat gaccccaaat acggcttaaa
     4801 tggtaatagt ggagatgact ttaagatttt tcttaccgtt tgggacgtat ggcaactttt
     4861 tgggacgctg gctcttttta tcctgaaaat atgacatact aatcatatga taatttgtga
     4921 tgaaagggtt tggtatgttt cgttttcgta ggacttttgt cctgtagcca agtttttctt
     4981 ctacttgatt taggtttggt atgtttcgtt ttcgtaggac ttttgtccct caaatagaca
     5041 tgagggattg tggagttgct gccttggcat cagtggccaa gtactatggt tcagattatt
     5101 cattagcaca tctgcgtgag ttggcgaaga ccaataaaga agggacaact gccttaggtc
     5161 ttgtagaggc tgctaaaaaa attggctttg aaacgagagc tataaaggct gaaatgtcgc
     5221 tctttgagat ggaagatgtt ccttatcctt ttattgctca tgttaataaa gatgggaagc
     5281 ttcaacatta ttatgttatt tataaaagca ccaaggatta tctgataatt ggagaccctg
     5341 atccaagtgt aaaagtaact aaaatgacta aagagcgttt tgagaaagag tggacaggtg
     5401 ttactctttt tatgggaccg gaacccagtt ataaaccaca taaggataag aaaaatggac
     5461 tctgggactt tctccctttg atctttaaac aaaggtcctt gatagctaat attgtctttg
     5521 ccagtctctt ggttacttta ataaatattt taggttccta ttatttacaa ggtattctag
     5581 acgaatatgt ccctaatcaa atgaagtcta ccttaggaat tatctcaatt ggattagttg
     5641 tgacctatgt tttacaacaa atgatgactt ttgcaagaga ttatctctta accatactga
     5701 gtcatcgatt taccattgac gttatcttgt cctacatacg acatatcttt gaactcccaa
     5761 tgtctttttt tgccacaaga cgtacagggg aggttatctc acgttttagt gatgctaact
     5821 ctattatcga tgctctggct tcgacgatat tatcactttt ccttgatttc tctattgtga
     5881 ttatcgtagg aggcgtgtta ttgatacaaa atagcaatct cttcaagcta gttctttgtt
     5941 cggttccaat ttataccctt atcgtctttg cctttatgaa accttttgag cgaatgaatc
     6001 atgacgtcat gcagagtaat gctatggtta attcagccat cattgaggac attaatggga
     6061 ttgaaaccat aaagtcacta accagcgaag aagtatgcta tcaaaagatt gatggtgagt
     6121 ttattgacta tctagacaat tcttttcgcc tttctaagtt atccatacta caaacatcat
     6181 tgaaacaagg tgctcaactt attttaaatg tacttatcct ctggacaggt gctcagttgg
     6241 tgatgggaaa taccatttcg ataggacaat tgattacttt taatatgttg ctttcttact
     6301 tcacgaatcc tttggaaaat atcattaacc tgcaaaccaa gttacagtct gctaaggtag
     6361 ctaatactag gctcaatgag gtctatctga ttgaatcaga gtttggacaa agtgatgata
     6421 cctatcaaga aggcattgcg gatggagata tcactgttac ggatttatct tataaatatg
     6481 gttttggtcg tgatactttg actgatgtca gtttgacgat tagacaagga gaaaaaatca
     6541 gttttgttgg tgtcagtgga tctggtaaga ctactctagc taaaatgttg gtcaattttt
     6601 atcaaccata taaggggcac atagatttta atggtcaaaa tattagtcgc atagacaaga
     6661 aaactcttcg tcaacatatt aactatctcc ctcagcaatc ctatatattt agtggtagtg
     6721 ttttagaaaa tcttacttta ggtgcagcac ggggtattac gcaagctgat attttgaaag
     6781 cttgtgaaat agcagaaatt cgtcaagata ttgaaaacat gcctatgggg tttcagacag
     6841 agctgtctga tggagcaggt ctgtctggag ggcaaaagca acgtatcgct ttggcgcgtg
     6901 cactactaac gaaatctcct gtactaatct tagatgaagc aactagcgga ttggatgttt
     6961 tgacagaaaa gcaggttatt gataacctcc tagcactaaa agataaaacg atcatctttg
     7021 tagcacacag gcttagtatc gctgagcgga ccgaccgtat cgtagtcatt gatcacggac
     7081 gcgtagtgga gacaggttct catcaagacc taatgtctta tccaggtttc tattatcaat
     7141 tatttagaaa gtgaggaaaa ggaaacacga tgaatccaca gttgtttaaa agcacagagt
     7201 tttaccatcg tcgctaccac aatatgtcta ctgttttgat tactcccttg attttgttag
     7261 ttattttcct ttttcttttc gctttttttg ctaagaagga agttacagtc acgtctagag
     7321 gaagtataga gccaaccaag gttatcgcag taatccaatc aaccagtgac aataccatca
     7381 tagataatca actggttgct aataaggttg ttaaaaaagg ggacacctta gttcagtatt
     7441 cagagaccat ggaggcatcg caaaaagagg ggcttcaaaa gcaactagaa cttttaaaaa
     7501 gacaggaatc aggtttgaag accttgcaat ctagcctaac gcagggaacc aatcttttcc
     7561 aagaacagga agacgagttt ggttatcaga gtacttttaa cacctaccta agtcaggcac
     7621 aggatattga cttgggtgtg gctaaaacaa atacagaggt taataaccaa gcagcaattg
     7681 cgagtaatac cggttctgct attgataacc agattagtca attgcagact caggtctcag
     7741 agtatgaggc gctctctcaa gctattacca atcatgaaac gactttacct gaaggcaatc
     7801 ctcatcaggc aaccttaaat gcctataaca gtcagtatgc tacgacaccg gatgccagtg
     7861 taacagacca atacctatct caagttaata ccaatatttc gagcttgaat gcttccatag
     7921 gtaatctaga aatccaaaag gctgggacag gcacagttgt aacttatgac aatagtgata
     7981 gcactaaaaa agaagctcta aaaaatcaat tcttgcaaaa tgcaggacag caattgagct
     8041 cagtggaaac acaaattaac gataccgaga gtaaaatcaa tcaggcagat gtccttctga
     8101 ctaataccct catccagtca ccagaagatg gaatcttaca cttgagtcaa gctgataaaa
     8161 aagcaaccat ggctgcgaca ggaactgagt tggcccagct ttatcccgat atgactcaaa
     8221 cccaggaagt tgccattact tattatgtga attcggatta tgtgccaaaa ctgcaaaaag
     8281 gccagtcagt tcgactgacc ttggataagg ttggtaatca cggtaccaca attattggaa
     8341 aacttgagag tattgataat tctgccacgg aaacagaaag ggggaatgtg tttagagtaa
     8401 ctgctagggc aagtatttca gaaaaagaag cccaaaatct acgttacggt ctagaaggtc
     8461 gtgtgacaag cgttattgac caaaagacct acttcaatta ctttaaagac aagttactaa
     8521 acttgcaaga ccaataggag gagaattact gatggctaac aatacgatta ataactttga
     8581 aacacttgat aaccacgctc ttgaacaagt cgtaggtgga agtgggtgga tggattatat
     8641 aaatggtttc ctaaaaggat tcggagggca aagaacgctt ccaacaaaag actataacat
     8701 tcctcaagct taggtataga aaaaaggctg ttaggccttt ttagttattg ttaattgttg
     8761 tgtgaatgag aaattgttac tctgtgtttc taagtttaca ttgatatagt tatctaagat
     8821 ttctgtgaca ttagcaaggc caatgcctcg ctctcgtccc ttgttggaga cacctctttc
     8881 aaatatggtt ttggtttctg ttttttcttc acttatggta ttgctaatag ataatagctg
     8941 tgaacaatga tcttcccaaa agctaatagt aattttaggg ttttgagttt gaatggcacc
     9001 ttcaatagcg ttatctaaaa aaatagaagt gacgataatg aagtccagag tctccatccc
     9061 aatcaagtgg atgggttctg ggatgctaat ctgagcttca ataccttctt cttctgcttg
     9121 taaaactttt gcggacagaa ggcttttcaa agtattatcc tgaatattaa cgagtctagc
     9181 taagtcaaag tttcttgtat ttaatcgttt atcggattct tgaagcacac tatcatagac
     9241 ttctttgaca atatccatat cgtctttatc tatccccaat cgtaatgtga ctaagagatt
     9301 actataatcg tgtctaaaac tacgaacaga attgtagaga cattcaatat gtttattgta
     9361 ggtgtagaga ttctctagct ggagattttt ctggaagtcc aattgtcctt gaatcatttc
     9421 acgaatgttt ctttctaaaa agacaatcat aatgaagaag aggacaagtg aaataacaat
     9481 acagagtttt cgaagctcca aagttgaaga gtgagtagtg ttttcaagat acatgaggga
     9541 ctgtaacagt agggtgtacc caaacataaa aaagttagca actataataa tatgttgaat
     9601 cggagaattt gatttctgct tttgaagtat ggtaaaactc tccttgaata atttaataaa
     9661 gagaaatgat agacaaagag gtgcgataga tgaagggatg gatattaata gagagctttt
     9721 ataatcggtg atactaatat taaaaaaagg aaagataaaa aaagtaatca gtcttaaact
     9781 aaggttgttg aggatatcag ggaagagacc attgaaaatc tttattttta atggtttttt
     9841 agtcttagtg gataaaagga aggagagcag aagatagtag atatcctcac cccagaattt
     9901 aatgataaac caagaagagt ggttataaat aaaattaaag gctaaattaa aaataaggag
     9961 taggaaaaaa tacctcagac gaatcttctg tcccattaaa taaaggaaaa gaataatttc
    10021 taggcctgca cttaaaaggg tgagaaaaag tagccataac gttgttaaca tcctctgcct
    10081 ctttcctcaa caatctgtgc aatctttcct atcttcatac gggatactgg taggacttga
    10141 ccattaatta aggtagcttc ataattggtc aagttgacag agataatcat atctgtattg
    10201 acgatatagg accgatggca tgggtagagc tttttgtgta tctttttaaa gtctgccaga
    10261 tttgctcgga tatccatgag ggtatggata gtctggaggt gaacatggtg tttgatatct
    10321 gatgtggata ggtatagaat ttgatccata ggaaggttta ttaattgaga ctctgttttg
    10381 tagagaaaaa actcatccgt ggtagttgcg ttaataggga agacttgagc aatggtttcc
    10441 cctatttctt ttctaaagct agcttcatct aaggttttat tgatgtattt ataggctgta
    10501 acgccaaaag cttgaggcat gaactctata tgtgtagtga caaaggcaat gatagcataa
    10561 gggttatttt gacgtatgat tttagcgata tcaagtccct tcttatcttc acctttaatt
    10621 tcaatatcaa gaaagaaaat ctgatcgctt gtattagaag tgatagctga taacaactgg
    10681 tcaggtttgt caaaagactg gacacaggat agatcttttc cgaaggtcat aagttcatgt
    10741 gctacagcat cttccaagcg acccatctga atagaattat cttctaatag gtaaatcttc
    10801 aaggtctagt cctctctttt atgacgaata ctgtttattg aaaaattgta acataaagaa
    10861 aacggttttt caatttttta tgagtgtaaa atgagaattt ttttctgaat tttagagact
    10921 ggatacatta gaaattacca ttcgggacgt atagccactt tttgggacgc tagctctgat
    10981 agagacactt gaatgctata ctaaagatgt gattgagaga tcacacgata aaaattttag
    11041 gaggtagttg ccatggcaac tcaaacaatt gaaaacttta acaccctcga cctcgaaaca
    11101 cttgctagtg ttgagggtgg gttgtcctgt gatgagggga tgctggcagt aggaggactt
    11161 ggtgcagtag gtggcccgtg gggagctgtc ggtggggtgt tagtaggtgc agccttatac
    11221 tgtttctaat ttgtatggga ggaatttatg aataataaac aacttgaaag atttaaaaaa
    11281 ctggatacaa atgcattgtc taatgtaagt ggtcaaggct atggtgctca atgtgttatt
    11341 ggtactaccg gaatgacgat tgtcggtgca gctttctttg gcatcgcagg tgcaggagct
    11401 ggatttgcag gcggtagcac agcattttgt tatgatacag ctaaataatc ttcatttgag
    11461 ataggtgata caaatgaaga aatacctaat cattttttcg actattgcga tgatatattt
    11521 atatagcaaa gtactattgt catcaggaaa tatctatcaa cttttgttag catcaatagg
    11581 attctttttc tttttatttg gagtctatag gcagtataga aagaattagt taaagctttt
    11641 tcaataagac atggactgaa tcaaaaatga tattcagtct tttttttact actcgggaca
    11701 tatagccact ttttgggacg ctagctctga tagagacact tgtatgctat actaaagatg
    11761 tgattgagag atcacacgat aaaaatttta ggaggtagtt gccatggcaa ctcaaacaat
    11821 tgaaaacttt aacacccttg acctcgaaac acttgctagt gttgaaggtg gtgtatgtag
    11881 ctggggaggt tttgctaaac aaggagtagc tacaggagtt ggtaatggtt tacgactagg
    11941 tatcaaaaca cgtacttggc aaggtgctgt cgcaggagca gctggaggtg ctatcgtagg
    12001 tggtgttggt tatggagcaa catgctggtg gtgatggatt atgtttgatt tgaaaagtta
    12061 tattttaggg atggtttcca tggctgttat gagtttttta gataagccaa ttatgtcatt
    12121 tcttgaaaaa cacaaggcta ccaattccgt taagaagaaa tcttccgtta agaagaaatc
    12181 ctaactgaaa tgtcttgtca attgctggtc tgtgaatagc atgtgaatta tgattgaaaa
    12241 tttcgatata agagaagagt tatttgtaat catgaccaaa aaacgcctag tgtctctaat
    12301 gatgtctatg ggcttcgtcc ttgttgcctt acataacttt ggagaaaaac tgaattttgg
    12361 acttcaatgc ctaaatctta tcgggttatg tttatttctc tttcttatgt gtacggttat
    12421 caaggatata aggtcagaca agtagtgaca tttatgtcac tactttttta tcggcttcca
    12481 atctataata aaattcatag attatgcaca gactagctaa aaacacttta aggagaaaag
    12541 tatgtttaaa aactcaaaac cgtatttact ggctaccatt ctcatcgtaa tgggcctcgc
    12601 taatctattt agaagcttgg atgcagttca ccataccatt aacttgctag ggctaacggt
    12661 gcttctttat agcttacttt ttaaaaagtg ggtacagttt caaaagtaac ctttggtcac
    12721 tttgaacgta agatgcttgc aaatgcttat ttttgatgtt cccgaagtaa aattattctt
    12781 gctaatgata gcggagatta tattatattt gattgcatat ctttgtaata gagaaaacaa
    12841 agatatgtat attcgcctat ttaaagtatc agtactaatg acactactgt attacatctc
    12901 cagtagaatt taatcgctaa gggcttactt gaaatcttac agctgtataa taaaatacag
    12961 agaggaatag agttaaatgt aatagcttat taggtttgca agactgactg aggttattca
    13021 tagtttaggt gttttatcat gaagttaaag aatattagtt cgagtgtatt gcgatctttt
    13081 agaaccatca ctgctgcgtt ggcagttttc cttataagta tcagcctttc tctctacaaa
    13141 agcaagatct cgccaggaac ttggctaaca gtcggagcac tagctttcgt agtcattttt
    13201 gttaatggac tgctctaccg tatgcttaag aagcgtccag attcagtaaa tctgttaaca
    13261 atacggcagt ccttcattgt ctttcctgtc atcacatttc tagtgcttag tgtagagttt
    13321 tacacattac taacattcag tgataccaca gaccgtatag tactagccgt attaatgctt
    13381 ttgttaatcc tctgtgattt tctatcttac cttcaagtca aaaaatattt taaacaataa
    13441 acgcatttgc ttgattattc tgtaagcaat ctataagata tttgcataaa agtgttataa
    13501 taagaaagtg attaagtaaa tatgtgaaaa ttagaggaag atttccaatg attgaaggat
    13561 gttctttagg aattaccatt cgggacatat agccactttt tgggacgcta gctctgatag
    13621 agacacttga atgctatact aaagatgtga ttgagagatc acacgataaa aattttaggg
    13681 ggtagttgcc atggcaactc aaacaattga aaaccttaac acccttgacc tcgaaacact
    13741 tgctagtgtt gaaggtggtg gatgtagctg gggaggcgca ggtggagcga ctgttcaagg
    13801 agctatcgga ggagctatcg gaggagcgtt tggaggtaat gtagttttac cagttgtagg
    13861 ctcagttcct ggttatctag ctggtggtgt tctaggtggt gcaggtggta ctgttgccta
    13921 tggagcaacc tgctggtgga gctaatctat ggtatatttt attataggtt ttgttgttgc
    13981 tttgttaggt aatatctttt tcaaaaaggt caataaaaat aaacataaaa aataatcttg
    14041 aacatatatt gaatagctcc ctgtcaagtg gacaatgaaa taataaaata ttaggcgacg
    14101 gccttgttc
//
