LOCUS       c00032_JAIQWJ0..       16844 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWJ010000008.1 Streptococcus thermophilus strain CF13_14
            NODE_8_length_93551_cov_37.425351, whole genome shotgun sequence.
ACCESSION   JAIQWJ010000008
VERSION     JAIQWJ010000008
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:20:40
            Original ID  :: JAIQWJ010000008.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16844
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16844
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5292:6844]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5293..6844
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..16844
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="neighbouring"
                     /product="RaS-RiPP"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..16844
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     protocluster    1..12803
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[643:2803](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      644..2803
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="2"
     cand_cluster    1..12803
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="2"
                     /tool="antismash"
     CDS             2..559
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_1"
                     /sec_met_domain="TIGR01716 (E-value: 3.6e-28, bitscore:
                     91.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="FNSTHKKIFLYNSILIDSFLISITGKKMNKKHIEVISDYLFDIDQ
                     WGKRELVILGNSMSAVPTNTLNLLIKEIIYKTTLFGNNEENKKIKIDLILNGISIFLER
                     KELNYAKFYIDLFDTLTIPEVYLYERVEYNILIGTYWILIGKIEVGKKKIELALESLKN
                     LGAENLLLMRENEYEELLNSII"
     CDS             644..2803
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_2"
                     /sec_met_domain="LANC_like (E-value: 5.4e-08, bitscore:
                     24.7, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.8e-14, bitscore: 45.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEELITPSEKRIINRKKGEIYDYISYSNAFVPYQGWKIHISANLI
                     DYQSILDNVYHVCSIFQTPFKYINKISELFRILSKHVSQLEIGKFITIYPKNKETFLLL
                     LEELYDKIPKYTGVQILTDRSYKDSEIIFYRYGVMNARLINNERPKLKFNGTFYEDITE
                     PYYTCPPFVEDIIFNKVVDDYNIESLFHDRYQMESIIHKSGAGNVYIAIDTINEEKVII
                     KEARKKVYITEKILAIDLLLNEKCILKKLKGKVDIPNYIECFTIEGNLYLVEEFIDGQR
                     LDILKPEYNLLIKRNSSELGRYNKKVKKIISNLFLSLYKIHQEGIILEDISSSNILLTN
                     DDRVFFIDLETAYNKNDGIIVETTNECYPKNISQKNEQRDIVKMWYCIIDLLTNSTSLL
                     KYDNTGVSTLNLFYKMSLENNLPKSLRKKFINDFSIVDFKNTFIIKFIEMGLNIEKIVR
                     MQQDLTETILSHNTFEIHGKTILESIDNYKHISNMDLKFSSDPSFSSLYDNCNKSIDDL
                     IGIAILDNNFELFLNYNLDELLHDMSYYQKYYLLRLFNDTKICDRVYFIKVLNSIIKND
                     IKCIDGVKYIKSNEYFSPYLITGNSGLIIELIKFSKNNNTMKFDEWIRSLSEGISYTYA
                     KGTSLYYGLAGLGLANAWLYYYFKETSFLKTSIKICEHIFDFSIKQNTKTILIDPMSEE
                     IDYTYSKGMLGQLYFINELLNIIKE"
     CDS             2808..4376
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 125; E-value: 6e-38)"
                     /gene_kind="transport"
                     /locus_tag="ctg32_3"
                     /transl_table=11
                     /translation="MKKYILKYKLLNLIHIILIGFSSAFLVGASVTLSIMLNKLVESDF
                     KGFLIWLGIEFGVYLLFLADTYLIRVNQTKLIQKMTLSLRDDYINSLTRKSFSEFKNKT
                     VGEHLSILNNDIKIIEESGFESFYSLVSTVFTTFFSIIALFSYDYRIVLLSILLTLILT
                     YLPRSFAHKMEKAMKRFSIGNETFISSLTDQLLGYDTLYYSNKKEMLSIKCGEVIKKFI
                     FEKIVFIKTSSLIEIIMSLFSIISQMLVLLLTGYLIILKQVSIGSISSVGQISGNIFNS
                     LTTFNQLQVSISSVNIIFEKFGAFEKSSHYRYIDKDIEEIKLTNVGYSFKDKEIFKNIN
                     CSFEKGKNYAIVGESGSGKSTLINIILGNNKQYSGSVKYNDVEISDIEESQLFKSVSYI
                     GNITHIYHDSLRNNLTLWDNKINESEIINILKQVNLIDLIPRLDDEVSMSFLSEGQKQR
                     LGIARAYLTKTNVIIMDESMANLDRDNAFLIENQLLNDPTRMYITVSHHLQEKLLDRFH
                     SIITL"
     CDS             5132..5275
                     /locus_tag="ctg32_4"
                     /transl_table=11
                     /translation="MKYGKIFKKFRESRGLSLKNVAKSGLSSSHLSRFENDEADLTISK
                     FF"
     CDS             5293..5991
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_5"
                     /sec_met_domain="TIGR01716 (E-value: 7.9e-49, bitscore:
                     158.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIEEFVYAVRDFRRDDFNELLEKIRYLVSNRDIDGMKKLLINQM
                     EKKDKKEPFASFNTILIKIRLQDLSGETYVTDQEIVTISDYLFSAEYWGYYELLLFMNT
                     IDAFNHNTMMILAKEMCHRSDFYRDIPNNRRLLATMLLNAYITCIERNEWMDALYFEKQ
                     LKYCNFSETEMYEKLVLHYANNLYDLKKNNNRHAVLEMRKCIAATKLVDSNQIAIKFEN
                     YLQKVLDDMR"
     CDS             6069..6176
                     /locus_tag="ctg32_6"
                     /transl_table=11
                     /translation="MEKLQVIDLEELLEFDQGYVINASCGPSHSCGGGR"
     CDS             6233..6844
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_7"
                     /sec_met_domain="PF04055 (E-value: 5.2e-16, bitscore: 52.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.7e-14, bitscore: 47.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTIETDIGTYYFDSVNFTLSLSPISKQSSPTLDSVEDGVLKKV
                     VINISNSCNLSCSYCYADGGNYGMDNRIMDLTTADNIIQEIASKGVTQINRLILFGGEP
                     FLNIELFIYFIEKLSTLLNVVKIETVTNGTVLNKRVKEMLVKFHPYLTISLDGPEIVHD
                     RLRGRGSHRKTLRFINYLKNIDYENFEIASTYTRLHQKMV"
     CDS             6877..7431
                     /locus_tag="ctg32_8"
                     /transl_table=11
                     /translation="MDVHFNINDVFTKNKVLIVKEMEKSLAERKQFIDKSIQHVINNNE
                     KAFISPILYDVLISMIYKSTNRTFCDDIDPSNTLTYDVDGSKKLCFRFWGTHNSPKAES
                     FNNKDNFEKCKNCWCRGMCLECVANVIDGYSSVISEDGEFLECSKPELMEYCIKQIIYL
                     SKDREKLSRLVNNFRGYIRYA"
     CDS             7424..8965
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 150.2; E-value:
                     1.4e-45)"
                     /gene_kind="transport"
                     /locus_tag="ctg32_9"
                     /transl_table=11
                     /translation="MLRSYVTKKHLTFYFLAIVITWLEAIITPALIQYIVASFTNRQLH
                     LLWQILLWGIGGNLVLVLGLAGKRYYYARLMTDFKVGIKRAIFRTFLYSRQIPDEEVLS
                     DLENDVQQLENSYIEPTVIIVSSLGFTVVSIAYALWTNFYLGLLFIIFYSVPVLCSGLG
                     SKRLDRIAEQKSLANQNYIARVNNMIAGVAPIRHYQGQNLFFKRFSKDLEQALQEEVSY
                     EKQRSLNSLFINSIDAFCSVAPIVIGGFMTYQNYLSAASFVGIYLVSHNIGYQFQELSY
                     FINTRKSAKSLCDKYQDLFGNKLATDSIFDQSVFPIQLEQVSVEKDGETILAPCDLTIH
                     AGEKIAIIGESGAGKTTLLNILYGEIHPSQGQIRYQGRELTSCQLYQAGAYILQSSHVF
                     DDLSVEENIALGQEIDQQRMDNILQETGLLSLKGKVPSNQTLSGGEKQRLEIARALYHK
                     RQFILADEVKANLDAKNQEKINQLLFSLPQAVVEVIHHYTKEDLKRYDKVIHLKK"
     CDS             9310..10320
                     /locus_tag="ctg32_10"
                     /transl_table=11
                     /translation="LTVFLKEGGTILLVSIQDLRSIQERCEIGELVQRLDVSIDRLTVI
                     WDTDTGSLRRIFKNLKQAISTRVDSFEIHDNVRDDVFTLAKDFNEYDSINIIFFQLSTY
                     GGEQLIRIDFNPNTLKEFDGMKVWRQLMYFARLNSLTVRLSRFDLAFDIFNRPKIVNLQ
                     HIKGGVTHKVFYGRGGELETKYWGSSGSNVQVRLYDKNKEIIAHKREEKLDLGVNPFWW
                     RLEFQLRTKAIGEDMVQDIMNRLDNFGFYKLEHIRVDQRAFTIIFLSNPELLSLAFPNL
                     KSDSIKKKKTRVRKLLREETNQFAEELKEVLIQNLPKLNTELQLLVGEFLTLENQ"
     CDS             10332..10520
                     /locus_tag="ctg32_11"
                     /transl_table=11
                     /translation="MDNNLISNKELIEMGYRPHTANDIIHQARELLVSRGYTFYNRKRL
                     MVVPKSVVNEILGTEVA"
     CDS             10522..11661
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 86.4; E-value: 4.9e-26)"
                     /gene_kind="other"
                     /locus_tag="ctg32_12"
                     /transl_table=11
                     /translation="MASVRYRKRGDSNLWTYEIRNEGKTVAHNSGFKTKKLAESEAEPI
                     LQELRLGKRISRDISLADLYQEWIELKILPSSRSEETKKKYLLRKNTIERLFGNKKVTQ
                     IRASEYQRIMNKYGQTVGRNFLGRLNTEIHQSIQMAIADKVLIDDFTQHVELFSSKEQQ
                     MTEEKYLHTEKDYLDLLLAVKRKFDYQRSIVPYIVYFLLKTGMRFGELVALTWNEVDFD
                     RGLLKTYRRYNTLSHKFVPPKNKTSIRMVPIDEECIKILRLLQTEQERANMELGIKNRY
                     RMIFQHFGYIHSVPDIASVNKALSVLLNELDIYPIITTKGARHTYGSYLWHKGFDLGVI
                     AKILGHRDISMLVEVYGHTLEEKIFEEFNQIRDIWKDCS"
     CDS             complement(12103..13371)
                     /locus_tag="ctg32_13"
                     /transl_table=11
                     /translation="MPDNLALRMRPRSISEVIGQKHLVGEGKIIRRMVEANMLSSMILY
                     GPPGIGKTSIASAIAGTTKFAFRTFNATVDSKKRLQEIAEEAKFSGGLVLLLDEIHRLD
                     KAKQDFLLPLLENGNIIMIGATTENPFFSVTPAIRSRVQIFELEPLSNEDIKEAILNVL
                     GDKERGFAFEVHLDDDALDFIATATNGDLRSAYNSLDLAVMSTPASGNGQHHITLDIVE
                     NSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVNASLHYAARLVEAGDLPSLARRLTVI
                     AYEDIGLANPDAQVHTVTALEAAQKIGFPEARILIANVVIDLALSPKSNSAYKAMDAAL
                     ADLRKSGNLPIPRHLRDGHYAGSKALGNAQDYKYPHAYPEKWVKQQYLPDKLRGVNYFQ
                     PNETGKYERALGANKERIDKLSR"
     CDS             13542..13730
                     /locus_tag="ctg32_14"
                     /transl_table=11
                     /translation="MAKVCYFTGRKTVSGNNRSHAMNKTKRVVKPNLQKVTVLIDGKPK
                     KVWASARALKSGKVERV"
     CDS             13857..14123
                     /locus_tag="ctg32_15"
                     /transl_table=11
                     /translation="MGFTDETVRFNLNDGDKDEISNTLTNVYRSLAEKGYNPINQIVGY
                     VLSGDPAYVPRYNDARNQIRKYERDEIVEELVRYYLKGNGTDL"
     CDS             14123..14542
                     /locus_tag="ctg32_16"
                     /transl_table=11
                     /translation="MRVMGLDVGSKTVGVAISDPLGFTAQGVEIIKINEEAKEFGFDRL
                     GELVKEYQVDKFVVGLPKNMNNTEGPRVEASKAYGDKIKEIFNLPVDYQDERLTTVQAE
                     RMLVEQADVSRGKRKKVIDKLAAQLILQNYLDRMF"
     CDS             14651..14956
                     /locus_tag="ctg32_17"
                     /transl_table=11
                     /translation="MSHNHDYNHDHEVITLVDEQGNETLFEILLTIDGREEFGKNYVLL
                     VPAGAEEDADGEIEIQAYSFTENEDGTEGDLQPIPEDSDAEWDMIEEVFNSFIDEN"
     CDS             15169..16815
                     /locus_tag="ctg32_18"
                     /transl_table=11
                     /translation="LSPYNKDNILGSGSYQGYHRSPHQSHTHDKQSEKGEVTIQGHTKE
                     STSYQIEKKTKISLPCKHKAHILILSLILSACSISVPCFTDFSNNIQSQNLYIAKMFAN
                     GSLPYSDFFATGGFFYYFLISLAFRLGSTLWLIPIQFLTYYLSGSYLYKVVMHMTNKKE
                     IATLISIIFFLINGTLGFGGLYPIQFAMPFVLGAIFFLTRYFAGHSRDEAFILYGFAGA
                     AGALFEARTLIFWVLSLVTIFVYNIVNKHFARGFYQVLCIIFGNILVLYLCLYFILNLQ
                     ITSDYINQVLVYNFTQLTVEKNNFLLTLAYQSFAVIGSGLLIGVVTIGNHLLGDAKDKI
                     IKWVLILSFIFTLVYSLFSQSFGLYSILTIVPYGLVLTALSLDDAIKKRAERTSHRRRN
                     DNQIRTLKVFGIFLSRNYFLPIVVFAFAFAIPIIMFLFDLGNNAERSSVANYLAKNTKK
                     DETIYVYDSSAKIYLKSNRKSASPFVLPDLNTAKSSHQKALLDTLVQDSAQYLVVQQDT
                     QLPSEFKSTLSKNYKKVPVKGVERYTIYVLK"
ORIGIN
        1 gtttaattcg acacacaaaa aaatattttt atataattct attttgattg attcattttt
       61 aatatcgata acaggtaaaa aaatgaataa aaaacatatt gaagttattt ctgattatct
      121 tttcgatata gatcaatggg ggaaaagaga gttagtaata ttaggtaata gtatgtcagc
      181 ggtgcctaca aatacattaa atttattaat aaaagaaatt atttataaga ctactttatt
      241 tggtaataat gaggaaaata aaaaaataaa aattgatctt attttaaacg gaatctcaat
      301 atttttagag aggaaagaac taaattatgc caagttctat attgatcttt ttgatacact
      361 taccattcct gaagtttatc tctatgagcg agtggaatat aatatattaa taggtacata
      421 ttggatactt ataggtaaaa tagaagtcgg caagaagaaa attgaactag ctttggaatc
      481 cctcaaaaat ttaggtgctg agaatttact gctaatgaga gaaaatgaat atgaagaatt
      541 attgaattct attatatgac actttttact aaaaataaaa tactgctgtt acactagtta
      601 tatagttata cagcagtatt ttatttttaa taggagattt atcatggaag aactaattac
      661 accaagtgaa aagagaatca ttaatagaaa aaaaggggaa atatatgatt atatttcata
      721 ttcaaatgct tttgttcctt atcaaggttg gaaaattcat atatctgcta atttaataga
      781 ttatcagtct attttagata atgtttacca tgtttgttct atttttcaaa cgccatttaa
      841 gtatatcaat aaaatatctg agttattccg tattttatca aaacacgttt cgcaattaga
      901 gattggaaaa tttataacta tatatcctaa aaacaaagaa acttttttat tattattgga
      961 agaactatat gataagatac ccaaatatac tggagttcaa attttgacag atagaagtta
     1021 taaagactca gaaataattt tttatagata tggagtaatg aatgcacgtt taattaataa
     1081 tgagcgacca aaacttaaat ttaatggaac cttttatgaa gatataacgg aaccatacta
     1141 tacatgtccc ccatttgttg aagatatcat atttaataaa gttgtagatg actataatat
     1201 tgaatcttta ttccatgata gatatcaaat ggaatctatt attcataaat caggagcagg
     1261 taatgtatat attgcgattg atactattaa tgaagaaaag gttattataa aagaagctag
     1321 aaaaaaagta tatattacag aaaagatttt agcaatagat ctccttttaa atgagaaatg
     1381 tattctaaaa aaattgaaag gtaaagttga tattccaaat tacattgagt gctttacaat
     1441 tgagggaaat ttatatcttg ttgaggaatt cattgatgga caaagattgg atattttaaa
     1501 gcctgaatat aatttgttga taaaacgaaa ttctagcgag ttaggaagat ataataaaaa
     1561 agtaaaaaaa ataatttcta atctattttt aagtttatat aaaatccatc aggagggaat
     1621 aatattagag gatatatctt caagtaatat tcttttaaca aatgatgata gagtattttt
     1681 tattgatctc gaaaccgcat ataataagaa tgatggaatt attgttgaga cgacaaatga
     1741 atgctatccc aaaaacattt ctcaaaaaaa tgaacagcga gatattgtta aaatgtggta
     1801 ttgtataatt gatttattaa ctaattctac tagtctttta aaatatgata atacaggagt
     1861 gagtacctta aatttatttt ataaaatgag tttagagaat aatttaccta aatctttaag
     1921 aaaaaaattt attaatgatt ttagtatagt ggactttaag aatacattta taataaaatt
     1981 tattgaaatg ggtttaaata tagaaaaaat agttagaatg caacaagatt taacagaaac
     2041 tatactttcc cataatactt ttgaaattca tggaaaaaca atattagagt caattgataa
     2101 ttataaacat attagtaata tggatttaaa attttctagc gatcccagtt tctcttctct
     2161 ttatgataat tgtaataaaa gtatagatga cttaatcgga atcgctatac ttgataataa
     2221 ttttgaactt tttttaaatt ataatttaga tgaactacta catgatatga gctactatca
     2281 aaaatattat ctactcagac ttttcaatga cactaaaata tgtgatagag tctactttat
     2341 aaaggtccta aattcaatca tcaaaaatga tattaagtgt attgatggag tgaaatatat
     2401 aaaatccaat gagtatttta gcccatattt aataactggt aactctgggt taatcattga
     2461 acttattaag ttcagtaaaa ataacaatac aatgaagttc gatgaatgga ttagaagttt
     2521 atcagaagga attagttata catatgctaa gggaacctca ttgtattatg gattagcagg
     2581 attgggtttg gcaaatgctt ggctttatta ttattttaaa gaaacttcat ttcttaaaac
     2641 gagtattaag atttgcgaac atatttttga tttttctatt aaacaaaata caaaaactat
     2701 attgatagac ccgatgtccg aagaaattga ttatacatat tcaaaaggaa tgttggggca
     2761 gttgtacttt attaatgagt tgctaaatat aattaaggaa taacataatg aaaaaatata
     2821 tactaaaata taaactgcta aatcttatac atataatatt aataggattt agttctgcat
     2881 ttttagttgg agcatcagtc acactctcaa tcatgttaaa taaattggtt gaaagtgatt
     2941 ttaaaggctt cctcatatgg ttaggcattg aatttggagt ttatttgtta tttttggcag
     3001 atacatactt aattagagta aatcagacta aattaattca aaaaatgact ctttctctca
     3061 gagatgatta tattaacagt ctaactagaa aatcgtttag tgaatttaaa aataagactg
     3121 ttggagaaca cttgtcaatt ttaaataacg atataaaaat tatcgaagaa agcggatttg
     3181 aaagctttta ttcattagtt tcaacagttt tcacaacttt tttttcaatt attgctctgt
     3241 ttagttatga ttatagaata gtgcttttat ctatactact tactttgatc ctaacttacc
     3301 ttccacgaag ttttgcccat aagatggaaa aagctatgaa aagattttct ataggtaatg
     3361 aaacatttat ttcatcacta acagatcaat tactgggata tgatacgcta tattattcaa
     3421 ataaaaaaga gatgttatca attaaatgtg gagaggtaat aaaaaaattt atttttgaaa
     3481 aaatagtatt tattaaaact agtagcttaa ttgaaataat aatgagttta ttttcaatta
     3541 tttctcaaat gttagtacta cttttaacag gttatcttat cattttaaaa caagtttcaa
     3601 ttggttcaat atcatcagtc ggacaaattt ccggaaatat atttaactca ttaactacgt
     3661 ttaatcaatt acaggtatca atatcatcag taaatattat atttgaaaaa tttggagctt
     3721 ttgagaagag ttcccattat agatatattg ataaagatat tgaagaaatc aagttaacta
     3781 atgtcgggta ttccttcaaa gataaggaaa ttttcaaaaa tataaattgt agttttgaaa
     3841 aaggaaaaaa ttatgccata gttggagagt caggtagtgg aaaatcaact ttaataaata
     3901 taattttagg aaataataag caatatagtg gaagtgtaaa atacaatgat gtagagatat
     3961 ctgatattga agaatctcaa ttgtttaaaa gcgtttcata tataggaaat attactcata
     4021 tttatcatga ctctcttaga aataatttaa cactttggga taataaaata aatgaatcag
     4081 aaattatcaa tatccttaaa caagttaatt taatagattt aattccacga ttagatgatg
     4141 aagtaagtat gtctttttta tcagaagggc aaaagcaaag attaggtatt gcacgtgcct
     4201 atcttactaa aactaacgta ataataatgg atgaatctat ggcaaattta gatagagata
     4261 acgcttttct aattgagaac cagctattaa acgatcctac aaggatgtac attactgtct
     4321 ctcatcactt acaggaaaaa ctactagata gatttcatag tattattaca ctttaaattg
     4381 agaattcaat gttactatac acaacaaaaa ttaatttata caaaaataat atttatcaaa
     4441 agtttggaaa ttatttcgtg gacaaatgat gggacatttc ctcttgagac aagtaaaaaa
     4501 gcctttattt aaaggctttt tttatgtata gtatgatgcc ccctacatga atttgtatga
     4561 atttttcata ttgaaaataa tcaaaaatgt tgaaatataa gttattttta gaagatactt
     4621 ggagcatttt taaatataat tatttcaaaa tggggcaaaa gtggggcaaa aacgaatgac
     4681 tcataaaggt ttccaacttg ctttgaaaac caggcttgaa aaaggctcgt aaagcatcga
     4741 aatttagtaa acgttaaaac tgatttacac ttattgaaag catttcgtat ccaaaatacg
     4801 ggattctttt tccataaaat caagagaggt tgggcaaaaa ctacaagttt acccttctga
     4861 ttaaaatttt aataaccaaa aatagcttgg aatcaacgtt tataatgacg caattctaag
     4921 ctatttttta tttttaaggt ttcttgccta atctctttat catttggcta acctactccg
     4981 ataacgataa taccttcaag tattacaaac aacaaactaa acaatgcttt tttattcatg
     5041 gtaaatacct cttttcgttt tcttatatga tataatattt ttaatatttg tgaagaaatt
     5101 tcccttataa gtaatttagg aggtgactag aatgaaatat ggaaaaattt ttaaaaaatt
     5161 tagagaatct cgaggtttat ctttaaaaaa tgttgcaaaa tcaggtcttt caagttccca
     5221 tctctcaaga tttgaaaatg atgaggctga tttaaccatc agcaaatttt tttagcgtta
     5281 gatgcaatac atatgcctat cgaagaattt gtttacgctg tacgtgattt ccgcagagat
     5341 gactttaatg aacttttaga aaagattcgg tatttagtat caaatcgtga tatagacgga
     5401 atgaaaaagc tattaattaa ccaaatggaa aagaaggata aaaaggaacc ttttgcttca
     5461 tttaacacaa ttttgattaa aataagatta caggatttat caggagaaac ttatgtaaca
     5521 gaccaagaga ttgttactat cagtgattac ttgttttctg cggaatactg gggttattat
     5581 gaattgctac tgtttatgaa tacaatagac gcttttaatc ataacacaat gatgatttta
     5641 gccaaagaaa tgtgtcatcg ttcggatttt tatagagata ttccaaataa tagacgttta
     5701 ttggcaacta tgttgctcaa tgcttatatc acctgtattg aacgcaatga atggatggac
     5761 gctctttatt ttgaaaaaca gctaaaatat tgtaactttt cagagactga aatgtatgaa
     5821 aaactagtgc tccattatgc taataattta tatgatctaa agaaaaataa taatcgacat
     5881 gctgttttgg aaatgagaaa atgtattgct gccacgaaat tggtagatag caatcaaata
     5941 gctataaaat ttgaaaatta tttacaaaaa gtattagatg acatgaggtg aattgcgtat
     6001 aagggaaaat attatcctct tctgataagg ttatataatg aaactatcaa ataaaggagg
     6061 taaaaaccat ggaaaaactt caggtgattg accttgaaga acttttagag tttgatcaag
     6121 ggtatgtaat taatgctagc tgtggtccaa gtcattcttg tggcggtggt cgatagcttc
     6181 ttccgagatg aggagtgatt cctcatctca gtttttagtc tggaggataa ttatgataaa
     6241 gacaatagaa acagatatag gaacatatta ttttgattct gttaatttta ctttatcttt
     6301 gtcacctatt tcaaaacaaa gttcaccaac tctagattct gttgaagatg gtgtattaaa
     6361 aaaagtagtt ataaatattt ctaatagttg taatttatct tgttcgtatt gttatgcaga
     6421 tggtggtaac tatggtatgg ataatcgtat tatggattta actactgctg ataatattat
     6481 ccaagagata gcaagtaaag gagttacaca aatcaaccgt ctcatacttt tcgggggaga
     6541 acctttttta aatatagaat tatttatata ttttatagaa aaattatcta cattattaaa
     6601 tgtagtgaaa attgaaacag ttactaatgg tactgtttta aataagcgtg ttaaagaaat
     6661 gcttgttaaa tttcatcctt atttaaccat aagtttagat ggaccagaaa ttgttcatga
     6721 tagactcaga ggaagaggga gccatcgaaa aacattacgt tttattaatt atttaaagaa
     6781 tattgattat gaaaattttg aaatagcctc gacatatact agacttcatc aaaaaatggt
     6841 ctaagtagag aagatatctt tcaatatttt actgatatgg atgtgcattt taatataaat
     6901 gatgttttta ctaaaaataa agtgctaatt gtgaaagaaa tggaaaaaag tttggctgaa
     6961 agaaaacagt tcatagataa atccattcaa catgtaatca acaacaatga gaaggcattt
     7021 atcagtccta ttttatatga tgtattaata tcaatgatat acaagagtac gaatcgtaca
     7081 ttttgtgatg atattgaccc ttcgaataca ttaacttatg atgtagatgg tagtaagaaa
     7141 ctatgtttca gattttgggg aactcacaac agtcctaaag cggaatcatt taacaacaaa
     7201 gataactttg aaaagtgtaa aaactgctgg tgtagaggta tgtgcttgga atgcgttgcc
     7261 aatgttattg atggatattc ttctgtaatt agtgaagatg gggaatttct tgaatgctct
     7321 aaaccagaac tgatggaata ctgtattaaa cagattatat atttatccaa ggacagagaa
     7381 aaattatcta ggttggtaaa taattttagg gggtatatac gctatgctta ggagttatgt
     7441 aacgaaaaaa catctcacct tctattttct agccatcgtc atcacttggt tagaggccat
     7501 tatcacccct gcccttatcc agtatatcgt cgctagtttt accaaccgcc agttgcatct
     7561 cctctggcag attttgctct gggggattgg gggcaatctg gtgcttgtcc tgggcttggc
     7621 tgggaagcgc tattactatg ctcgtttgat gactgacttt aaggttggga taaaacgcgc
     7681 tatttttcgg acttttttat acagccgtca gattcctgat gaggaggtgc tgtctgatct
     7741 ggaaaatgat gtccaacagt tggaaaatag ctatatagag ccgaccgtca ttatcgtatc
     7801 ctcgctaggt tttacagtcg tttccatcgc atatgccctc tggaccaatt tctatctggg
     7861 gttattgttt atcatctttt actcggtacc agttttgtgt agcggactgg gttcgaagcg
     7921 tttggatagg attgcggagc aaaaatccct ggcaaatcag aattatatcg ctcgtgtcaa
     7981 caatatgatt gcaggtgttg ctcctattcg tcattatcag ggccagaatt tgtttttcaa
     8041 gagattttct aaagacctag aacaggcgtt gcaagaagaa gtgtcctacg aaaagcaacg
     8101 gtcactgaac agtttattta tcaacagtat agatgcattt tgctctgtgg cgcccattgt
     8161 gattggcgga ttcatgacct accagaacta cctttctgcg gctagttttg tcggcattta
     8221 tctggtctcc cacaacatcg gctaccagtt tcaagaactg tcctacttta tcaatacccg
     8281 caagtctgcc aagtccctct gcgataagta tcaagacttg tttggaaata agttggctac
     8341 tgacagcata tttgaccaat ctgtctttcc tatccagttg gagcaggtca gtgtggagaa
     8401 ggatggggag accattctag ctccttgtga tctgactatc cacgctgggg aaaagattgc
     8461 tatcatcgga gaaagcggag cgggcaaaac caccctgctc aacatcctat acggggaaat
     8521 ccatcctagt caggggcaaa ttcgttatca aggacgggaa ctaaccagct gtcaactcta
     8581 tcaggctggt gcctatatct tgcaatctag tcatgttttt gacgatttat ctgtggagga
     8641 aaacatcgct ctgggacagg aaattgacca gcaaagaatg gataacatct tgcaagaaac
     8701 agggctcctc agcctaaaag gcaaggtacc cagcaaccaa actttatcag gcggtgaaaa
     8761 acagcgcctt gaaatcgccc gtgctctcta tcacaagcga cagtttatcc tagcagatga
     8821 ggtcaaggct aacctggacg ccaaaaatca agaaaaaatc aaccagctgc tcttttcact
     8881 tcctcaagct gtggtggagg tcattcacca ctacaccaag gaagacttga agcgctatga
     8941 taaagtgatt catttgaaaa agtagttatg ccaatagtgt ctatagacaa attgtatatc
     9001 tgaaaggctc tttgtcaact gtcttgagtt gatgaaaagc taacatcgag agaggacaca
     9061 attcgttctc tcttttctta tcttcaaagt gataagaatg cgttttttaa agttttcaaa
     9121 gttcctaaaa tctcatttag aaattgtgtg gacaagggca agggacgagc ctgacgtgaa
     9181 gtcaggcgaa gtcctgcagg ctgccgtcca gacaatttct agccaagcaa aagctggcta
     9241 ttctaacagc cagcaaaaag gtacacttag gacaacgtcc aaagaacgac ggaacgagca
     9301 aacgttgatt tgacggtgtt tctaaaagaa ggggggacaa ttttgttggt ttctatacaa
     9361 gatttaagaa gcattcaaga acgatgtgaa ataggagaat tagtacagag gttagatgtc
     9421 agtattgata gattaacggt tatctgggat acagacactg gttccctaag acgaattttc
     9481 aaaaatctga aacaggcaat aagtacaaga gttgactcat ttgaaataca tgataacgtg
     9541 cgagatgatg tctttacttt agctaaggat tttaatgagt atgattcaat caatattata
     9601 tttttccaat tatccactta tggaggtgaa caattgattc ggattgattt caatcctaac
     9661 actttaaaag aatttgatgg aatgaaagta tggaggcaat taatgtactt tgccagattg
     9721 aattcattga cggtacgttt gtctcgtttt gatttggcat ttgacatttt caacaggcct
     9781 aaaatcgtta atttgcaaca tattaaaggt ggtgttaccc ataaggtctt ctatggtaga
     9841 gggggcgaat tagagacgaa atattggggt tctagcggta gtaatgtaca agttaggtta
     9901 tatgataaga ataaagaaat cattgctcat aagcgcgaag agaagctaga tttgggtgta
     9961 aatccgtttt ggtggagact agagttccaa ctcagaacta aagcgattgg ggaggatatg
    10021 gtgcaagata ttatgaatcg acttgataat ttcggatttt ataagctaga acatattcga
    10081 gtggatcaaa gagcctttac aattatcttt ctaagcaatc ctgaactgtt atcattagct
    10141 tttccaaatt taaaatcaga cagcatcaaa aagaaaaaaa caagagtccg caaactattg
    10201 agagaagaaa cgaatcaatt tgcggaagaa ttaaaagaag tattaataca gaatctccct
    10261 aaattaaata cagaattaca actacttgta ggtgagtttc tgactttaga aaatcaataa
    10321 ggaggataac tatggataat aatttaatta gcaacaaaga attaattgaa atgggctatc
    10381 gccctcacac tgcaaatgat atcatccatc aggcaagaga attacttgta tcacgaggct
    10441 atacatttta taatcgcaaa cgtttgatgg ttgttccaaa aagtgttgta aatgagattc
    10501 taggaacaga ggtggcgtaa tatggcaagt gttcgttacc gaaagcgagg agatagtaat
    10561 ttatggacct atgaaattcg taacgaagga aaaactgttg ctcataatag cggttttaaa
    10621 acaaaaaaac ttgcagagtc agaagctgaa ccgattctgc aagaacttcg tttaggaaaa
    10681 agaatttcta gagatatttc tcttgccgat ctatatcaag aatggattga actaaaaatt
    10741 ttaccaagta gtaggtcgga agaaacaaag aaaaaatatc ttctccgtaa aaacacaatt
    10801 gaaagattat ttggaaataa aaaagtcact caaattcgtg cgagtgaata ccaaagaatt
    10861 atgaataagt atgggcaaac agttggtaga aattttcttg gtagattgaa tacggagatt
    10921 catcagagca tccaaatggc aattgctgac aaagttctaa tagatgattt tacacaacat
    10981 gtcgagttgt tttcatccaa agaacaacag atgacagaag agaaatattt acatacagaa
    11041 aaggactatc tggatttact tttagcagta aagagaaaat tcgattacca acgttcaatt
    11101 gttccttata tcgtctattt tctattaaaa acaggcatga ggtttggaga gttagtagcg
    11161 ttaacttgga atgaggttga ttttgacaga ggattgttaa aaacatacag gaggtataat
    11221 actctctctc ataagtttgt tccaccaaaa aataaaacgt ctattcggat ggttccaata
    11281 gacgaagagt gtatcaaaat tttgcgcctt ttacaaacgg agcaagaaag agcaaacatg
    11341 gagttaggaa tcaaaaatcg atatcgaatg atctttcaac attttggata tattcattca
    11401 gttccagata ttgcaagcgt caataaagct ttgagtgttc tcttaaatga gttggacatt
    11461 tatccaatta tcacgacaaa aggagcacgt cacacctatg gaagctacct ctggcacaaa
    11521 gggtttgacc ttggagttat tgcaaaaatt ctagggcata gagatatttc aatgttggta
    11581 gaagtatatg gacacacttt agaagagaaa atttttgagg aatttaatca aatcagagat
    11641 atctggaaag attgctcata aaaaaatgtg gggcaaacga tggggcaaat gctcttaaga
    11701 caagcaaaaa agccttggtt atcaaggctt ttactgttga agtttgatgc cccctacagg
    11761 gctcgaacct gtgacccatg gattaagagt ccactgctct accaactgag ctaaggaggc
    11821 tggatgctgt attggtaccg atgatccaca gtttgtattg aacccgcgac gtaaaaaagc
    11881 aggtgggcga ctcgctacta acttcagttg cttctgggtg ggccagcctg cacactgtta
    11941 atagacctct gtctcccgat aatacaaaaa ttagtcggtc aacacttata tgtggattcg
    12001 tataccacag caatttctat gtttttataa taccactttt gaaaattatt gcaagaggaa
    12061 aaatcatttt ttttgcaatc gttttcgttg attcttctcg tattatctag ataacttatc
    12121 gattcgttct ttattagctc caagagctct ttcgtatttc ccagtttcat taggttggaa
    12181 ataattgact cctcttaatt tatctggaag gtattgttgc ttaacccact tttcaggata
    12241 ggcatgtgga tacttataat cttgtgcatt acccagtgcc ttacttccag catagtgtcc
    12301 atctctcaga tgacgcggaa taggtaaatt cccagacttt ctaagatccg ccagggcagc
    12361 atccattgcc ttataagccg aattcgactt aggtgataat gctaagtcaa taactacgtt
    12421 ggcaatcaaa atacgtgcct ccggaaaacc tattttctgt gcagcttcca aggctgtgac
    12481 cgtgtgaact tgtgcatctg gattagctaa accaatatcc tcataggcaa tcacagtcaa
    12541 gcgacgtgct agactaggca aatcccctgc ctcaaccaaa cgtgccgcat agtgaagact
    12601 ggcattaaca tcagatcctc gaatagattt ttgcaaggca gaaaggacat catagtgccc
    12661 atcaccgtct ttatccatag taatataact gcgttgtaag ctattttcca ctatgtctaa
    12721 ggtaatatga tgctgaccat ttcctgaagc tggtgtcgac atgacagcca gatccaaaga
    12781 attatatgcc gatcgtaaat caccattagt agctgtcgca ataaaatcta gagcatcatc
    12841 atctaagtga acctcaaagg cgaagccacg ctccttgtcc cctagaacat tcaaaatagc
    12901 ttccttgata tcttcattag agagtggttc caactcaaat atttgtacac ggctacggat
    12961 ggctggtgtc acagaaaaaa acggattctc ggttgtggca ccaatcatga taatatttcc
    13021 gttctctaat aatggtaaca aaaaatcttg tttcgcttta tccaaacgat ggatctcatc
    13081 tagaagtaga actaaaccac ctgaaaattt agcctcttct gcaatttcct gtagacgttt
    13141 tttgctatcg acagtggcat taaaagttct aaaagcaaat tttgttgttc ctgcaatagc
    13201 actggctatc gaggttttcc cgattcctgg aggtccgtag agaatcattg acgacagcat
    13261 attcgcctct accatacggc gaataatttt accttcacca actaaatgct tctgaccaat
    13321 cacctctgaa attgaacgtg gacgcatgcg taaagcaaga ttatctggca tcttctctcc
    13381 ttttttttaa ctatttattc ttcttataat aagaatatac tatttttctg taaaaagaaa
    13441 ttataaatag ttcttgtcaa acctaaattc ttatgataga atattttggt atgtggtgct
    13501 agcacatccg taataaattc tacctaggag gaaaacacga aatggctaaa gtatgttact
    13561 ttacaggacg taaaactgtt tctggaaaca accgttcaca cgctatgaac aaaactaaac
    13621 gtgtcgttaa gcctaacctt caaaaagtta ctgttcttat cgatggtaaa cctaaaaaag
    13681 tttgggcttc agctcgtgca cttaaatctg gtaaagttga acgcgtttaa tcttattaga
    13741 tattaaaaga gatgacatca gtcatctctt ttaatattca tcgtctttca cttttgggta
    13801 tacttatgtt ataataagaa actaatagat aatccttata gaaagaaggt gtcagtatgg
    13861 gatttacaga tgaaactgtt cgtttcaacc taaacgacgg tgataaagat gaaatcagta
    13921 atactttgac aaatgtctac cgttcgttgg ctgagaaagg ttataatcct atcaaccaaa
    13981 tcgttggtta tgttctgagc ggtgaccctg cttatgttcc gcgttacaat gatgcccgta
    14041 accaaattcg caaatacgaa cgtgatgaaa tcgttgaaga actcgttcgc tattatctta
    14101 aaggaaatgg aactgacctc taatgcgagt aatgggactt gatgttggct caaaaacagt
    14161 gggtgttgct attagtgacc cacttggttt tacggcccaa ggcgttgaaa ttatcaaaat
    14221 taacgaggaa gctaaagagt ttggcttcga ccgtctaggt gaactcgtta aagaatatca
    14281 ggtagataaa tttgtcgttg gtctccctaa aaatatgaat aacactgaag gaccacgtgt
    14341 tgaggctagc aaagcttatg gtgataaaat taaggaaatc tttaaccttc ctgtagatta
    14401 ccaagacgag cgattgacaa ctgttcaggc agaacgtatg ttagttgaac aagcagatgt
    14461 cagccgtggt aagcgtaaaa aagttattga taaattggct gctcaactta ttctgcaaaa
    14521 ctacctcgat cgaatgtttt aataaactgt aaatagagac caattagtcg agcgacaatc
    14581 tagtgaactc ccagtcagaa cttctagatt cacctcacta ttgaatactc tcaccaaaaa
    14641 ggagaacaat atgtcacaca atcacgatta caaccatgac catgaagtca tcactttagt
    14701 agacgaacaa gggaatgaaa cactttttga aatcttatta acgattgatg gacgtgaaga
    14761 attcggtaag aactatgttc ttttggttcc agctggtgct gaagaagatg cagatggaga
    14821 aatcgaaatc caggcatact cattcactga aaatgaggac ggcactgaag gcgaccttca
    14881 accaattcct gaagattcag atgctgaatg ggatatgatt gaagaagttt tcaatagctt
    14941 tatcgatgaa aactaaaaaa taatattggg cgtaactaag cctaatcatt tacttctaaa
    15001 aaagagactg aaatagttta tttcagtctc ttttttagac ggtcttttct taaatgtaag
    15061 aaataagaga gaaattgact aaatggtatt atctgatata ctttaaataa gatattttgg
    15121 ttttttccct tatttgtaac tttcaaaatg acagcaaagg agtttaattt gagtccatat
    15181 aacaaagaca atatcctagg atcaggtagc tatcaaggtt atcatcgaag cccccatcaa
    15241 tctcatacac atgataagca atctgaaaag ggtgaagtaa caattcaagg gcatacaaaa
    15301 gaatcaactt cttatcagat agagaaaaaa actaaaattt cacttccttg taagcataaa
    15361 gcacatatcc ttatcctcag tctgattttg agtgcatgta gtatatcagt cccttgcttt
    15421 acagactttt ccaataatat acaatcccaa aacctttaca ttgcaaaaat gtttgccaac
    15481 ggtagtttac cctattctga cttttttgcg acaggtgggt tcttctatta tttcctaatt
    15541 tctctggctt ttcgtctggg gtctactctt tggttaattc caatacagtt tctaacctac
    15601 tatctttctg gcagctacct ttacaaggtt gtcatgcata tgacaaataa gaaggaaatt
    15661 gcaactctaa ttagtattat tttcttttta attaatggga cacttggttt tggtggactc
    15721 tatcctatcc aatttgccat gccttttgtc ctcggtgcta ttttcttctt aacccggtac
    15781 tttgctggtc acagtcgtga tgaagccttt attctttacg gttttgctgg tgctgctgga
    15841 gcactctttg aagctcgaac tcttattttc tgggtattgt cacttgtgac aatattcgtt
    15901 tacaatattg tcaacaagca ctttgctcgt ggtttttatc aagtcctttg tattattttt
    15961 ggtaatattt tagtactgta cctatgcctt tatttcatcc taaacttgca aatcacttcg
    16021 gactatatta atcaagttct agtttacaac tttacacaac tcactgtaga aaaaaataac
    16081 ttcctactga cattggctta ccaaagtttt gctgttatag gttctggact ccttattggt
    16141 gtagttacta taggtaacca tctccttggt gatgctaaag ataaaatcat taaatgggta
    16201 ttaatcctta gctttatctt tacactagtt tacagtctat tctctcaaag ttttggactt
    16261 tacagcattc ttaccatcgt cccatatggt ttagtcttga ctgcactttc tctggatgat
    16321 gctattaaaa agagagcgga gcgaacctct caccgacgtc gtaatgataa ccaaatccgc
    16381 acgctaaaag tttttggtat cttccttagc cgtaattatt tcttacctat agtcgttttt
    16441 gcatttgcct ttgctatacc aatcatcatg ttcctatttg atttaggaaa taatgctgaa
    16501 cgtagcagtg tcgcaaatta cctcgctaaa aataccaaga aagatgaaac tatttacgtt
    16561 tatgattcat ccgcaaaaat ttatttgaaa agtaatcgta aatcagcttc accatttgtt
    16621 cttcctgatc ttaacacagc taaatcaagt catcaaaagg ctcttttaga cactcttgtt
    16681 caagattctg cacaatatct tgttgtccaa caagatacgc aattgccttc tgagtttaaa
    16741 tcgacacttt caaaaaacta taaaaaagta cctgtaaaag gcgttgaacg atatactatc
    16801 tatgtcctaa aataggtcga aaatcaatat atagtggttg agat
//
