LOCUS       c00013_JAIQWM0..       16743 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWM010000021.1 Streptococcus thermophilus strain CF5_14
            NODE_21_length_34027_cov_161.406864, whole genome shotgun sequence.
ACCESSION   JAIQWM010000021
VERSION     JAIQWM010000021
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:22:34
            Original ID  :: JAIQWM010000021.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16743
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16743
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4318:6743]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4319..6743
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..16743
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16743
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             209..310
                     /locus_tag="ctg13_1"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             480..749
                     /locus_tag="ctg13_2"
                     /transl_table=11
                     /translation="VQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             909..1208
                     /locus_tag="ctg13_3"
                     /transl_table=11
                     /translation="LCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1308..2219)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg13_4"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2449..2538)
                     /locus_tag="ctg13_5"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2535..3146)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_6"
                     /sec_met_domain="TIGR04085 (E-value: 6.1e-16, bitscore:
                     49.7, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.8e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNDMLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERIS
                     KGEFKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGV
                     RACSINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCS
                     ECPLPWCGGGCRCSALKLDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3231..4322)
                     /locus_tag="ctg13_7"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4319..5638)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_8"
                     /sec_met_domain="PF04055 (E-value: 2.5e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.4e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7e-14, bitscore: 43.1,
                     seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 5e-25, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(5708..5851)
                     /locus_tag="ctg13_9"
                     /transl_table=11
                     /translation="VLKRNIITVSYSKGVPNMSKELEKVLESSSMAKGDGWKVMAKGDG
                     WE"
     CDS             complement(5883..6743)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_10"
                     /sec_met_domain="TIGR01716 (E-value: 2.5e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(6983..7819)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.7; E-value: 3.2e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg13_11"
                     /transl_table=11
                     /translation="LVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(7813..8379)
                     /locus_tag="ctg13_12"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(8558..8716)
                     /locus_tag="ctg13_13"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9037..9501)
                     /locus_tag="ctg13_14"
                     /transl_table=11
                     /translation="VKSLSISSSFFSISTSSTPQLTANSIGQHSTAKQSRKEIELAAAK
                     LVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQPYMTESAYSQELTSQNDAM
                     NQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSDLKNANQSKTN"
     CDS             complement(9781..12960)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 496.3; E-value: 3.2e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg13_15"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDRFQKSLEERLRQSNKDMDKRQAQIDSHFASQVWSE
                     EELTVLASTPASEKLARLEEFLSQRQESLTEQKSILKAAHEDLAQLQKSFQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELAIQSEDFLQKEEELETWKEDIIYSQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLESLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLMIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVTKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIRKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(12957..14183)
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.8; E-value: 6.2e-77)"
                     /gene_kind="other"
                     /locus_tag="ctg13_16"
                     /transl_table=11
                     /translation="MNEEVVMKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEK
                     VDGVIISGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFF
                     QHQGLHLSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYIL
                     EDMKKAFDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFD
                     YVALGHIHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLE
                     VKRPIVALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTD
                     IVEITFSRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESV
                     FEEIERSRQ"
ORIGIN
        1 aactattcat tagaatagga gacataacat gaaacactat ccagacgaaa cacgataaaa
       61 aattgttcga ctgcacattc aagacggatg aacattaaaa agcttagctg ctgaatatgg
      121 cgtatcccaa gcctcaatct ctaattgggt aagacattat cgcaaagaat gccaaactaa
      181 taataaagaa aaatcacagc ttgaactcat ggaggaggtt cgtaaattac gtcaagaaaa
      241 ggcagagctt gaaaaggaaa atgatttctt aaaaaaagca gcggcattct ttgcaaagga
      301 aatcgattag aggcatatcg ttttattgat aactataaag aagattttgg tttgcgttgg
      361 ttgttcttgc atatgaatat tcatcccaat gcttattata attatcttaa aaagacaagg
      421 actaactatc atcgtcaaaa gaaagctatt cttaatacta ttcgagatat ctaccatgag
      481 tgcaatggaa agaagtaaat caattcttcg aaacagaaag catcaaactt tctgatatag
      541 agccttcgaa agttagttat agggaggtac aaaggaatca aatcaatacc actatttata
      601 atgaaaaagg taatataaag gatattgata ctagcattat aagagatatg tacgataaaa
      661 gcaaacctac tttaaaacag ggagcctata tatccgctat agcagcttct ctagaagggg
      721 ggtactgcat ttataacagc aataattaaa aaaagcgctt agggaaaact attagtgagt
      781 ttacaaaaga cgattgtctt gaaatttcta aagatagtgg aattggagct ataaaaggaa
      841 gtactcgagg cattacgata tacgccctaa cgaattacac agctactcct gcagcagtag
      901 caagttcatt gtgcactgct tcatttggta tcgctaaaga agcatacaaa ttccgtaaaa
      961 acttaatcac aaaagaagaa tttttactaa attcgcaaat attatgtgtt gaagtatcag
     1021 ttagtgcatt atcctcaata ttaggacatg ctgtaattcc aatacctatt ttaggatccg
     1081 ttattggaaa taatatagga actttcctat atgaaatcgc taaagataat ctcacaatga
     1141 aagagaaatt actgatagca gattatttca aagagataca agaatataac tattttttag
     1201 ataattaatt tgaattatat aatcatcaac ttcagagaga ttaagaatta ctataaactt
     1261 ttagggaagg cattttctcc tgactataat atcgcttttc agggatctta tgaattttta
     1321 aatatgtttt ttaaaaatac gttaacctct cctattttct ctgcttcagg taaatagata
     1381 gaaacggttg tcgaataaac aaaagaaggt acactcacaa ttgaaagcaa ttgactaata
     1441 actgcataaa tagccaacaa ttctactcct aatctcgaca tcaaggcatc aaacaccata
     1501 ataaacaaaa cactctccag aatttcttga ccaaccaaag gaataccaaa tgttattaat
     1561 tcaaatttag ttgtagatgt aatggataaa gccttcaaaa tcattggata aaccataaac
     1621 aagtaactaa gcgatatgaa agctaaggat acaatcgttg atatggctgc tcccttaatt
     1681 ccgatttgtg gtaccagtac ataatttaac acaacatcta ttaatgaact gataagtcca
     1741 acccacataa ttggttttgt tttcttttga actcttaata aatttgtcag cgaaaagttt
     1801 aataatgtca atccgatata tggagacatg aagactaaat aaatggtgga taaggacaat
     1861 agttgccctt taaatccata gagctgcttc aagattacat ttccaaaaat aatgacaaaa
     1921 accgcaaagg caactccgat aattaaatct aaggttagat ttgatttcaa taaatcatca
     1981 aacctgttag tttgccgatt agagtacgcc ttagagcttt taatattaaa tgacaaactg
     2041 aatgctccta aaagtccacc aaaagcaaat aagagattct gaataatgga aattcctgac
     2101 agagcaattg aggaattgtt cacagcaaaa tgcaatgcta tctgcccaat aattacttga
     2161 ccaatatttg ttaaaactaa gggaaaggca aatttgttaa tttcttttga atctatcatt
     2221 tttcctctct aaaaggcttc aaatgtaagt aaagatcaga tttaactaaa tttgcataaa
     2281 taatatgcaa aataggagtt tcttctaaaa atgaaataat tgcctgctta caatcattag
     2341 cagatacctc ataatcttgc tgtaatagtt ctacaatctt gtctaaagaa aaatttttag
     2401 aaatgcaata aagtatttct gctcctattt catcaaatga atagtactct aatcaagtag
     2461 atcgtatcct atgtattcat ctgctacttt atttacaatg aaatctctct tacctcttat
     2521 cacaaaatgt tctttcatac gactactcca cctccttttt gttcataaaa gcaggctaaa
     2581 tcagagccca gtaacgttcc atctaatttc aaggcactgc atcgacatcc cccaccacac
     2641 catggtaggg gacattctga acatttccca gaaatatcat caaatgtaat tgatcttagt
     2701 ttattaaata cagcagaatg gtgccaaatt tcgctaaact tttgttcttt aacatttcca
     2761 gcaactaatt catctatacc attcatcaag tcacacccgt atacatctcc tttatgatta
     2821 attgaacatg ctctaactcc agcttgacaa gatatttccc ttggcttatc aaaatttata
     2881 tctacttttt gatgccaaac attttctaat aaatctgatc tattataaaa tgcaagcgga
     2941 aaataatgtg tcaaaaaaac atcactttca ttaggaggaa caattttaaa tttaactttg
     3001 aactctcctt tagaaatccg ctctgttaaa tcaagaaaaa caggatacca ttgtttttta
     3061 tctgctaaaa tactaccgtc attagcccta ccagtaggac aaataaccat aactgacata
     3121 tactcaatac caagcatatc attcaatctt atactctaaa gaaaatatct gctaaatttg
     3181 caaacaattg tgctatcaat aatttggcaa atgaattaga aatacaactt ttaagttctt
     3241 ttctctctgt tagaaaatga ataagatact aagcaacaaa gagctactat accaaatatt
     3301 aaataattgc tcctaatact aaagttatca gcaaaaatac cagctaggaa atcagctaac
     3361 ataaaactaa tcgaaataaa caaattatat actgaccatg atactgctct atttttttct
     3421 attgacatat taaatttata ataaaaatga ttattgtagt tggaattaag aacacgcatt
     3481 aataaaagga ttataatttg gatgattaga ttagtttgaa aaaacatgag tatagctaat
     3541 actggtaaca tcaagcttac ttcaaactta atttttagat aactccccaa agccatagat
     3601 atattaaaca taaatagtat aattcccagc atatctagtg aaagtccctg ttcatttaag
     3661 aatatccctg cataagaatt gctaatcata attagagttg agaatgctac tcctaatatt
     3721 attaataacc atggaatatt ttgaatatta tcgaggctaa aaaatttttg tttattattt
     3781 tgttcctttt taatctcggg taatcctatt aaatataata aactgaaaat tacaaataca
     3841 atggatataa taataggata aatataattc ctatgcaata aaggtggaga tataatcgta
     3901 ataatagcaa taaaaatata ttttaatgtg ttgagatttt tcaaaaatga tttatataca
     3961 acttcgtcat caattatttc aaaattataa gaaataagaa ctcctgaaga taatgattct
     4021 gacaatccaa aaaatatcgc tgaaatatat attatatttg attttccaaa caataggccc
     4081 cataatgcta aaattaataa taaatttgaa atagccaaaa ttttcttgta accaatctta
     4141 cttgaaatat aacttaaagg aatatcaaaa actgagccac atagctcagt aataactgat
     4201 aaagtagcta tttctgtgaa cgaaaaacct aagtgcttta atagtaaaat tcctacaaag
     4261 tagtacggta atccagatag aaacatattc attccgtata aattaaaaat cttcttactc
     4321 ataagttaca aactgggtct ctaaaatatt ttggactctt ctccttaatc aagttaacat
     4381 agcagccacc ctcgcaaatt tttaacaatc cacaagataa acacttagaa ttcttcgttc
     4441 taaaagaacg aatccctcca tacaacggat catcatacca aacatctaac aaatcttttt
     4501 caaaggcatt ctgcttagtt tgattaactc ctaaaaaagc aatgcaaggc aagatatccc
     4561 cattagacat tatttccatc ttagtatatt ttgcacgaca tccataatac atttcgccaa
     4621 actctgaaaa ttcaattgaa ttatttatca actccggata agcggtgaaa agatgacatc
     4681 cctcagtagc aaaatttaaa ttagcttccc gttgagttat ataatctgta acatactcat
     4741 tcaaccttct caaatcagct aaatcgtatt ttttctttat tttcgtatat cctgttacct
     4801 cagaataatt agctactgaa aatctatcta ttttattctc tatacaaaaa tcaaccaatt
     4861 ctataatctg ctcatagctt tgctttgtat acactgcatt aattctacat ttttttccaa
     4921 cctctttaaa gtacttcgct aatttaattt gtctatcagg tctcaccccc attaattcaa
     4981 aatttaattt aggatctaaa gtctgcaaag ataaaaccgg tgtaatatat ttagatttag
     5041 ctagaatttc cactgtactt ttctttatta attgggcatt agttgttata gtagtcttta
     5101 tcttcagttc ttcacaagct atcaacaaat tatcaatatc aaaatatcta gtcggttccc
     5161 ctcctaaaat tgaaacactt aacactccat tatcttttgc ttggcgcaaa attctttccc
     5221 aatctttagc aggtttggca tttctatctt cacgatttgc taaaaaacaa aaaccacatt
     5281 ttaaatcaca gtacatactg gggtatatta ctagttcaag cggaaaactc aatatgttat
     5341 gtttttttaa ttttgctaca tgctttctcg cattttgaag agtctcgtca ggatttttcg
     5401 atgatccctc aatattatta tcagaataga tatttaataa gagtactcgc tctagtttcc
     5461 ctgcttttat ttctttctta aaaaaggacg tagcaatttc aaaaccatga ttttgaacca
     5521 aataaagaaa ataagcttca ctctcatcta actcaattcg gtcaaaagtt actttattta
     5581 tcaaaattcc accaaacttt tctagtctaa ataaaaaatc ttctgaaatt gtcatcatat
     5641 tgaatacctt tctaaaaaag cagaggaaaa tatagcctct gcttaactta tgggataaat
     5701 tactttatca ctcccagccg tcaccttttg ccatcacctt ccagccgtca ccttttgcca
     5761 ttgaactaga ctcaaggact ttttcaagct ctttagacat atttggtact cctttcgaat
     5821 atgatactgt gattatattt cttttcaaca cttacaataa aatattccca tatttgcatt
     5881 ttctaactac tagctaaaat tttttctaaa tgtccttcat aagtctttgc taagtgatga
     5941 cttcctgcta atttcatcgc tccaacacac ttcttcattt caataattgc tttcacattt
     6001 ccatcctctt tatattgata aagattttgt gcatacttaa agactaaacg ttcatatact
     6061 tctgtctcaa taaaaaagca ttgatttagc tgcttttcaa aatataaagc atccataaat
     6121 ttttctcttt caacacatgt aatatatcca tttaaaagca tcgttgaaat taatcgtctg
     6181 ttatttggaa tttctttgta aaaatcagaa cgcctaaaca tttctcttgc taagaccatg
     6241 aaaacatcat gatttaatac atctaaagta ttcgagaaaa tcaataactc atagtacccc
     6301 cagtattcta cactaaagag ataatctgtt aaatatgtca aatcatcctt tgtatagtaa
     6361 gtttctcctg ataaatcctg tagacgaatt ttcaataaaa taatattgat ttgatgaaat
     6421 ttttctcgcc tatcttccag ttccatctga gaataaagta attttttcat accttctacg
     6481 tcacgtgttg acacaaaatg acgtactttc gataacagtt cgtttaactc atctctatga
     6541 aaatcatgga ccgcatacat aaattcatct attggcatat tgatttcatc taaaataaac
     6601 atgaactttg aaatcgttaa atctgtttct cctttctcaa atcgagagag ctgagacgtt
     6661 gatataccag cctttgcgac gtcttttaat cgtaatcctc tcgattctcg aaacttttta
     6721 aaaatttctc caaatttttt catactacac ctccatcacg catatatggg aataattttc
     6781 atttgctttc atcatatcat acaataaaga aaaacaaaag tgaggattat cacatgaaaa
     6841 agcaaatttt actaacactt cttcttgtcg tatttgaagg cattatcgtt atcgtcgtgg
     6901 gataaagagt ctgggacaaa agtcctttag ctccaaaaag caacggcata atgtactgac
     6961 cccaaaaagt tagacaaata atttaagtaa aggatttagt tctgtattgt acaggactga
     7021 gtccttttag ttttacctta atgcgtttgt tgttgtaata attaatatag tctgcaattg
     7081 cttgttccaa atgctcaatt gacttaaacg tcttctcata accataaaac atctcagact
     7141 taagaatgcc aaagaaggat tccatcatgc cgttgtctgg actattgcct ttacgtgaca
     7201 tggatggttg gattcctttc tcctctaaaa aatgatgata gaaatcatgt tgatattgcc
     7261 atccctggtc actatggaga attgtatttt tgtaatgttt ctctgtaaag gcttgttcta
     7321 acatagcttt cacttgtatc aagttcggtg acttagaaag attgtaggcg ataatttcac
     7381 tattgaagcc atctaaaatt ggcgacaaat agagtttttg gctgcttgct ggaatggcaa
     7441 attctgttac atctgtgtag catttttcca atggtttgga tgcttcgaac tggcgttgga
     7501 tgagattctc tgctttcata ccaacctctc cttgatatga agaatactta cgtttacggc
     7561 gaattctagc ggttaaacca agtactttca taagacgttg aactctctta tgattaatca
     7621 caattcctcg atttctcaat tcaagagtca ttcgacgata gccgtaattt cctttatgct
     7681 cagtaaaaat ggcttgaatt tcagctttaa tgtcataatc cttatcattt tgatccagct
     7741 gttttaagtg gtaataatag gttgaacgag caagcttaat aatctttaga agcatatcta
     7801 aagaaaactc agttaccaat cctcggacaa tttccgtttt tcttcttgct ctttttcttc
     7861 cctcaatcgg agttctctca actttttaag aactgcattc tccgctctaa ggtactcatt
     7921 ttctgcttga agacgttcca tttcttccag ttttttcttt ggcttacgtc ccattttaga
     7981 taaccttcct cttgttttct caacaatagt atacccgttt ttcttatagt gtgcgagcca
     8041 gttaggaagc gtcccacgat ttgggagagc atattcaaga gaaactctat cttgagaata
     8101 gcctttatat aggactttat caatcatttc ttgttttaat tcaggagagt agtaacgatt
     8161 ctttcctttt ttagcgattt ctattccgta tcgatcaatc aatttaatca tgtagctaag
     8221 attagaaatg tttatcccaa atttatttga aagctgatct aagctatatc cttggtttct
     8281 aagttcatag atttgaacct tatcttcata agtcaatttc ataataaaaa caccccgaaa
     8341 gttagatttt ttctgtctaa cttttggggt gcagttcata aaaccgttgc tttttgcatg
     8401 attgtgatag acttggtgaa atagaattga ccaaaaatct tctgaaatat aacaagagag
     8461 tgactcgaat ttaaaaagct agagttccac aattggaaat ctctagcttt tttgtgactg
     8521 agaacttttt gtcccagcct ctactttcta ctgactacta tcctgcatgc cctaagtcga
     8581 gatagagaat atctcgctta gtggcatact ctagcgcatg ttcaacagcc tcaaataaat
     8641 ctgaagctag aaaccttttc gtaaagacgg tttcgtcttt acgcttaaat ttcgcaacat
     8701 aactatgttt agtcattttt tctccttcta atattcatat tgtcctttaa caccactata
     8761 gatccagtaa actgctttat cataaacttg tttaaaggag atacctaatc gattggctac
     8821 atcaagaatt gaaatttgct tacattcctc tatattcata aaatatcatc attttgtcgt
     8881 agtattcggc aatgatggaa cagatgagga ttcttctaaa gttttaggag ttgccttatc
     8941 tagatcatct aacccagatt tccaaacctg tacttggttg accaataact taccaggtag
     9001 tttcgaatag ttcaaattaa ccgttctggt ttctgtttag tttgtctttg attggttggc
     9061 attctttaaa tcagatacat aagttacatt ataagagacc atggcaatgg cttgattcgt
     9121 agtctgattg acaaagatat ctgctttttc aaaatgataa tccaaaatat agtccttata
     9181 cacttggttc atggcatcat tttgacttgt caattcttga gaataggccg attcagtcat
     9241 ataaggttga atacgtgtat tattttcccc tagtttttct ttcgtatagt actgtgtcaa
     9301 aaattctttt acagtatctg atgataaaat acttgcttta tcttctgctt gtttgtcctc
     9361 tacaagttta gctgcagcca attcgatttc ttttcgactt tgtttggcag tagaatgttg
     9421 accaatagaa ttagcagtaa gttgtggtgt tgatgaggtg gatatactaa aaaatgagga
     9481 ggaaattgat aatgacttca cctagctaaa agttcaacga attagggaga cattaggtag
     9541 cctcatatta ccttgattag tttttgctat aacattgtca aatatgatga caaaaaaatc
     9601 cgtccgcact tttttacgag taggacgaat taaatatgtt atacaaacca tcagcttttt
     9661 aacaattcta cataaggtag ttgttaatgc aactaccttt tttctatgtt gattagaaca
     9721 aatttgacat ggctacaact gcgattatct gatatagagt attatataaa ctgattcctc
     9781 ctacccctta tccacaattt taatacggct actgccatcg tgcgacttga tgataactag
     9841 ttgctgagca ataccttctt tcatatcgtc cacgtggctg atgacaccga ccatgcgatt
     9901 ttcaccgatt tgttctagga cagagatagc cttagtgagg gcttccttat caagtgaacc
     9961 gaaaccttcg tcgatgaaga gtgcttcaac aacggcaccc ttgctggtat tttggacaac
    10021 ttctgagagg gatagggcaa tggccagtgc agcgataaag gtttcaccac cagacaagga
    10081 tttaacggag cgttcactac ctgtcagctg gtcatagacg ttgatatcca aaccgaagtg
    10141 atcacgcgcc ctgcgtcctt cctcacttag aacaaaggaa tagcggttat ccgttaatag
    10201 tccgatgtag ttagcattgg catagtccaa gatttgttgg aaatactgac ggataacgta
    10261 gacctcaaga ttaagacgac cagttagagc agtattttct cccttaacca ccttaaccaa
    10321 atcactgagt tcttggtggg ccttaaaggc ctcttggttg ctgtcttgaa gggttttagc
    10381 cgcttggtag gtagccgtcg catccttaag tcccttttcc atgacagaaa actgagcgag
    10441 ctgcctatca tagatttcct gacaattctg tactgcttgc gctagactat cgagatctgg
    10501 ttgttcttga ttttggagaa gctcttgccc cttacgaatc tgcgcctgta attcttgttt
    10561 gagcgttgca taggtcgtta atttggcctg aagcatagga atagcttgat tatttacctc
    10621 aataagccag agttcgacct gctctaagtc attggcgagg gctccttcag ccttgagact
    10681 ttgctctaat tcagcagata atcgcttaac atcttgattt accttatctt tagacttagt
    10741 tatactctca atctgcccct tgattccttt aatgtcggca tgaagttggt tgtaggcttc
    10801 gctattttcc ttgacttgct tattgtagag gttcagctcc tgatgagcaa gggaaatccg
    10861 ttcttgatat acctcaacag actcaagttc tggatgagct tcctgcaagt cctctaggcg
    10921 ttcttgagct tggtcaagca ctgccttggc ctcttgatag gttttagcca aatctgtcgc
    10981 ttttttttga gccttaccta gctcatcttg atatcggata taatctgtct cttccttatc
    11041 ataacgtttt tgtaactctt gataatactg ctcaaccttc aggagtaggg cttgcccacg
    11101 gtcagtttca tagtctatcg aaaaatcaaa atcaaaccgt cccttaacgt gctcttctaa
    11161 ttcttgatag tgcttttcaa gagttgcctt gactttagtc acttggtcaa gcaaatcctg
    11221 acgtttagat gcaacttcac tcaaggtagc ctgacgattt gataaagtag cgacttgctt
    11281 ttctttttga gcttgaagct tctccacctg atccatgaga tttttcaagg ccacttcatc
    11341 agcctgtgct ccaccaacat tagggtgttc cagagcacca caaaccatac aaggatgccc
    11401 ctcctctaac tctgcctgca gttggacaat catgagttga cggcgtgaaa ccaaagtcct
    11461 tcttaactcc tcttccaatt ctttgagaat ttcttgagct tgatcaatat caaaagataa
    11521 cgtttgatga cgtttttcgg tctttgtcaa ctcctgattc aagttctcta tctctttcag
    11581 gtcctgagca agttgattct ccacactgta gcccacaatc tggaagagtt tttcggcctc
    11641 atgtaaactc tctaaactaa gacgattagc ctccaagtca gacaaggact tgttaagcat
    11701 ctcaacctct tttctagcct gctgataggt ctcttccaac tgcttgtagt tagtcgttga
    11761 acgtttgatt ttctcctgtt cttgggcaag actctgggaa tagataatat cctctttcca
    11821 agtttcaagc tcctcttctt tttgaagaaa atcctcagat tgaattgcga gttcctcttt
    11881 tttagcctta acatcctcaa acgcctgttg cttttcactt aaggcttctt gagcaatttc
    11941 aaggtcctgc tctaattgca tcaactgttt ccgatactgc ttcaaggtcc gaatggtttc
    12001 ctgcagacct tgagcaaact gtaattcctc cagatgcact tttgcctctg cctgtccttg
    12061 agccccctcc tcaatttcca gacggtaacg ttccttggct tgctccaatt cttgaaaaat
    12121 ctttgccaaa tcttgggcag tttggaagct cttctgcagt tgtgccaaat cctcgtgggc
    12181 agccttcaag atactttttt gctccgtaag actttcttga cgctgagaca aaaactcttc
    12241 aagacgtgcc aatttttcag aggctggcgt tgacgccaag acagttaatt cttcctccga
    12301 ccaaacctga ctggcaaagt ggctatctat ctgagcctga cgcttatcca tatccttatt
    12361 gctctgacga agacgctctt ccaaactctt ttgaaaacgg tcaaagatac ctgtcccaaa
    12421 gattttcttt aaaatttgag tcttagtctt ggaatcttcc ttcaaaaaac ggctaaaatc
    12481 attttgcggt aagaggataa tctgtttgaa ctgctcagca ttgagcccca aaatctgctc
    12541 aatctggtca ctcacttcct tgatcttatc cccaagcttt tcaatttcct gaccaccaat
    12601 cttatccaca atgactagag aagccgtcgc cttttgcatg gtagtgcccc caccctgctt
    12661 ggccctctct tgctggagaa ctcggtcaat gcgataaagg tgattgcctt gttggaaata
    12721 gaaagtcacc ttggtcaaat catcctctgg accagcgaaa gttgaccgca tctcctcaac
    12781 attacgatca ccactggtcg tagcaaacaa ggctaccgtc atggcatcaa agagagtact
    12841 cttaccagcc cctgtatccc ctccaatcaa aaagagggga gcatggtcaa actgagtgaa
    12901 attaataact tccttacgat atggtccaaa attggtcaat tctaactgga ctggtctcat
    12961 tgtcgactcc tctcaatctc ctcaaaaaca ctttccacaa gggcagtctg tctctcagat
    13021 aagacatcgc ccccagttac tgtctggtaa aaatcaaata cgatttcctg gggcgactgc
    13081 atttccaaat cttttaagtg ctgatcaacg gtcaagtttt cttccctaac atcacccaga
    13141 cgactgaaag taatttctac aatgtctgtc ccataaatct cttccagtcg ggcacgcaca
    13201 ttgataccct ctaattcctt acgactagac agttgaatat caaaggcgaa ccaggctttt
    13261 tgacaaggtt gattcttata aaattcaggt gacatcaagg tttcaaaaga ttcctgtaaa
    13321 gccacaatcg gccgtttaac ctctagagta tggaaggtct gagacatatc accagacgca
    13381 tccaattcaa gaatatagac acccttttct tccttacgct tggcttcttt gacattaaag
    13441 gcgactggac tgcctgaata ttgcacgcgc ttggtaggac tagcaaaacg cgtatggata
    13501 tgccctaagg caacataatc gaaagacttg aaaaggtcac tggtcacatt ggtaagacca
    13561 cctaccgtat tactggtttc agacaacatc aattctcgaa gaccctgacc atcgctatca
    13621 tccttcttag aaaccgcaaa atgcgtcacc aagacatgag ctttgtcagg atcaaaagct
    13681 tttttcatat cctcaagaat gtaggtcaag gcatcaccaa tcccctgaat ttcctttccc
    13741 tcatcatcct tatagtaaat acgagcatca ataggatcga taaaaggcag cagaaaaatc
    13801 tggcaattct ccaactcaat gggctcaaaa gcctcctcca aacgtgtact taaatgaagg
    13861 ccctgatgtt gaaagaagtc acgcccaaaa tgtaaacgtt cagccccatc gtgattacca
    13921 ctaatcgcat agacaggaat ctgctcctcc agtaccaagc gggccaaggt cttattaaaa
    13981 agcttaatcg catccacagg gggcaccgca cggtcataga ggtccccaga aatgataacc
    14041 ccatccactt tttcgctaat agccaaatcc acaatttgtt gaaaagccca ctcctgctcc
    14101 tccaacaaag accagccatt gagggttcgt cctacatgcc aatctgacgt atgtaaaaac
    14161 ttcatgacaa cctcctcatt cattttgtct tacttctatt gtaccttatc aagctaaata
    14221 ctgcttaaaa gtttcacagg ctttgatagt tttcccgttt tttagctgta aagatcaaaa
    14281 aatctctccc aagctatcct gtactgaccc caaaaagtta gacaatttat gtaagcaaag
    14341 gatttagctc tgtattgcac aggattgagt ccttttagtt ttaccttaat gcatttgttg
    14401 ttgtagtaat caatatagtc tagattaccc tgcctcaatt ggttaagtaa tttaaatacc
    14461 tctaaccaag aaaatcaata ttatctattc ttttaattga cttttataga ttctaagcat
    14521 tatcatatag gttggtacta gtgcacatct tgtattttag gcaataatat ttactcactt
    14581 ttcgttattg tcagtaccga tcctttttaa atttttcacc atgaaaacct aaaaataatc
    14641 cgaaccctaa gggctcctga ctttttactt tattctaggc tttttttatc cgtagcttgt
    14701 tagctgactt ggaactaggc atgtagtatt tactatttcc ctacttgaga ttttttataa
    14761 gtcacatgca ttattccatc tgaacgaatg gtatgatttt tatttctttt agagaaacac
    14821 cggtaatagc taattcctat cttaaatcac ttgaaatata tttataatgt gttggagtgc
    14881 taatcagtac cgcttgtaga tttttggaag atactaacac actaatgatt taatctcctt
    14941 taaaacatga aaagagaagc ctccaaagct tctcttttat aattatcaaa taatgtacaa
    15001 ctagattctt aataactacc taatttagtg gttcaatcat gaagcttaat tgatagctat
    15061 ctgctgagct aagcaagaat tcgtcatgaa ctggagcacc ccatgtgtcg tcaccaccta
    15121 cacccatttg agcagcaaga actttaatcc atgtagcatc agattcttgc aactcatatt
    15181 ggtgacgagc attttcaatt tgttcagtac tgttacgcaa agcactgaat tcgaatgctt
    15241 tattaagtgc ggtgaattta agaccattat ggttatcatc agatactgtg aattcacgag
    15301 taccatagtg attaccagat tcttgtggca ttagatatgg agcaaatgtc ttttcaacag
    15361 atgtttcata tcgaccaaga taggcaccag gaagtttatc acggtagctt tcttctgcac
    15421 cgtatccata atagctaagg tttgtaaatt gtgaaccgat agcaaattct agaccaaatt
    15481 cagggaagtt tggcaaacct gctttaccat catagtttgc agtaacaaag attcgaccct
    15541 tgtaatcaac ttgataagtt accttaactt cgacatcaga caagcctggc aattcatgaa
    15601 cataagtcac tttaacagag tcgtcttcga tttgaatttg agtatctgta actttactat
    15661 agtttccagc aaccttccag cctgccattt cgaatggata tccagcacca cgatcgttgt
    15721 cagtgtaagc acgagtgaag ctaagtttag gacctttctc aatgaattca acaccattat
    15781 acttagcaga tactaaagta ttttgtgcac gtgaaagcaa gattgagaag ttttgtcctt
    15841 gaataccgat gttgaagtcg ccttcaacaa cattcaaagg tgctttaact ggtgtttcag
    15901 tgctaatctt ttcaacaaca tattgaccac gaacaatttc atgaccttta ggagcccatt
    15961 cagttgcttc cctcagaaca caagcaactt cgtaaatttg ttcagaattt gaagcctcga
    16021 ctacaaagtt aactgggaat gttgcttctt cgcctggttt aacatcaaag tgatattcac
    16081 tttcactaac ttttctacca tcttcgtaaa ctctagctag gaaagtataa gcagaaagat
    16141 cttcgaagag attatcattc ttgatagtta ctgatttttc atcaacagca atcttaatat
    16201 tagagtaaag atgtttaact gtttgaagtt ttggagttag ggtacgatct gcaaagacga
    16261 taccatttcc acaaaattcg tagtcagaag gtctatcatg ccagtcacca ccatatgata
    16321 ggaattcgct accatttgga agtgttttgt aaatagcttg gtcaatgaag tcccaaataa
    16381 atccaccttg gtattctgga tatttctcta agtcagtgta gagttgcaat ccaccaccag
    16441 agttacccat tgtgtgcatg tattcacatg aaatataagg tttttgaggt ttgttagtta
    16501 ggttacctga agcaaagtgt ttatcactaa cgcttgaaag atcaactagt ttaccagttg
    16561 tgaggtattc ttcgatatca gctggtttcg catacatacg actttcgatg tctgtaatgt
    16621 aatcaaactc acgacaccat gcaacacctt catagtgaac tggacgagta ttgtcaacac
    16681 tacggaagta atcagccatg tcagcaatat ctttaccagc atatgattca ttaccacaag
    16741 acc
//
