LOCUS       c00036_JAIQWO0..        6708 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWO010000042.1 Streptococcus thermophilus strain CF8_14
            NODE_42_length_6708_cov_25.463099, whole genome shotgun sequence.
ACCESSION   JAIQWO010000042
VERSION     JAIQWO010000042
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:24:38
            Original ID  :: JAIQWO010000042.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6708
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6708
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[303:3195](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      304..3195
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..6708
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6708
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             2..115
                     /locus_tag="ctg36_1"
                     /transl_table=11
                     /translation="RLEELQKDGTLAKLAEKFFGNKDYIPTKDALKVPSKK"
     CDS             304..3195
                     /NRPS_PKS="Domain: AMP-binding (6-388). E-value: 5.1e-65.
                     Score: 211.4. Matches aSDomain:
                     nrpspksdomains_ctg36_2_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     173.2; E-value: 1.2e-52)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_2"
                     /sec_met_domain="AMP-binding (E-value: 3.8e-64, bitscore:
                     204.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.5e-07, bitscore:
                     20.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILKTFSDTVKQYPSKVAVMYSGGEFTFQEVDVMSNFIAKQLLL
                     NSDEETVPFYIEKNKYVLPVVLGIMKSGKIPLPITNSLEVKISLERISEVVFDVLISDR
                     DVKLENHSVTLLVLPKKLESYSEYQEVATTKENEIAHIICTSGTTGVPKKVFLTDDNID
                     WLVKEFYKIVKFTSESKFLFTTPYTFDVSLTEILAPVYTGGTLVCYDGGIQNIIRLGET
                     IEQKKITHLSLSPSFAETIIDISGPEVFQNLRALCLAGETFPSSLANRLRGLIQQGCRV
                     FNLYGPSETTIYATYYELKDRKYNTVPIGKPLPGVQLKIASQKENSKMAELLIGGNGVT
                     EGYRLQPELNKAKFKLIGSNRYYVTGDYVYYQGDNLVFSSRIDSQVQVNGIRIELDEVK
                     SIVDKLKTVKSSRVVFYKKKLVVFYEADLNIKEDIIRSLPSYLNPTVVKVESYYLNQNR
                     KLDVPKMLEIYYYKKQSQQGDDVRKNILDVLSKFERVDITDLDSLELVRFYLEIEDIFD
                     IEIKENDFYRLKSVDSIVDYIRNKSFFQERSTEPNDSFTKEHDLVNLEYNLTKMNYRYL
                     KNIITPSPTQKRLYKNNQNRVIGFNLALEEVTYLELNKLHHIIKYLSYKIDIFRLVVEK
                     EQTRFSIGIVNEGDYSPNIIVLNNLPTELELQGILDNIEVIPIPIIVVGTRDKKVRFYF
                     PYHSIDASSLNKLGDTVYQLYEKKIVIDEVPSSSLVAFSQFKREVLQNDVSGDVLARLP
                     KIKPAIEFEKLNDEVQCFQVSLPEDIKGDDVYLFTIYAISQCILSDYNLSAISGGLSLD
                     FRDYEQFDAYDLIGDIHKKIPFQVNRTETFEEFKNSHFKILEIYRTGIDYYEIAMLGND
                     MSAKEVQERLNNLSLSINFIGEAFRLKDTINNIIDVDFDKNFINVFVHERFAYAVIKSE
                     LLSNSVYDLMHKDSKFELKVIDKKRLENEETNR"
     aSDomain        322..1467
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg36_2_AMP-binding.1"
                     /evalue="5.10E-65"
                     /label="ctg36_2_AMP-binding.1"
                     /locus_tag="ctg36_2"
                     /protein_end="388"
                     /protein_start="6"
                     /score="211.4"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FSDTVKQYPSKVAVMYSGGEFTFQEVDVMSNFIAKQLLLNSDEET
                     VPFYIEKNKYVLPVVLGIMKSGKIPLPITNSLEVKISLERISEVVFDVLISDRDVKLEN
                     HSVTLLVLPKKLESYSEYQEVATTKENEIAHIICTSGTTGVPKKVFLTDDNIDWLVKEF
                     YKIVKFTSESKFLFTTPYTFDVSLTEILAPVYTGGTLVCYDGGIQNIIRLGETIEQKKI
                     THLSLSPSFAETIIDISGPEVFQNLRALCLAGETFPSSLANRLRGLIQQGCRVFNLYGP
                     SETTIYATYYELKDRKYNTVPIGKPLPGVQLKIASQKENSKMAELLIGGNGVTEGYRLQ
                     PELNKAKFKLIGSNRYYVTGDYVYYQGDNLVFSSRIDSQVQV"
     aSModule        322..1467
                     /domains="nrpspksdomains_ctg36_2_AMP-binding.1"
                     /incomplete
                     /locus_tags="ctg36_2"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       721..777
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg36_2_0001"
                     /evalue="1.00E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg36_2"
                     /protein_end="158"
                     /protein_start="139"
                     /score="15.1"
                     /tool="antismash"
                     /translation="AHIICTSGTTGVPKKVFLT"
     CDS_motif       1294..1365
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg36_2_0002"
                     /evalue="2.80E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg36_2"
                     /protein_end="354"
                     /protein_start="330"
                     /score="19.7"
                     /tool="antismash"
                     /translation="ELLIGGNGVTEGYRLQPELNKAKF"
     CDS_motif       1441..1497
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg36_2_0003"
                     /evalue="2.60E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg36_2"
                     /protein_end="398"
                     /protein_start="379"
                     /score="20.0"
                     /tool="antismash"
                     /translation="SRIDSQVQVNGIRIELDEV"
     CDS_motif       2077..2124
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg36_2_0004"
                     /evalue="1.30E+01"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg36_2"
                     /protein_end="607"
                     /protein_start="591"
                     /score="-0.8"
                     /tool="antismash"
                     /translation="NNQNRVIGFNLALEEV"
     CDS             3192..4838
                     /locus_tag="ctg36_3"
                     /transl_table=11
                     /translation="MSIYKDIVEGYQLNNIQEKDKLNNVLVQLNEKDDQEMINRKNFIG
                     HFTASAFVISKDNRRLLMVHHNILKRYLQPGGHIDKNDRNPLDAAKRELFEETGIDSEI
                     LTYQCAEPLNSLIPFNVSVHKIPENKLKNERSHYHYDLQYLFYIENEVDVKIDSNESSS
                     YEWIQLDNVKDMDGYKEIIKKIEKLEAASQERFLSNMLKGASFEDISCITVQHIIPSTI
                     PIIMTLQKIFGHRLLVCAKPNSVDKMVWHKLENMGVRLTLASRDEYFNVDYLGIKSKTI
                     LLDIGGYFASIAQIPNLPIECIIEDTENGIQKYENVIDQIEYPLFSVARNPLKKNEDYL
                     VGADIVFGTDYILHQKNLLMQYMQVVCIGYGKIGYGICTKLRELGIRPKVLEKDSMRTI
                     QAVRDGCDILLEKDFKNIDLIFCATGSKSLDILDFRSIKDGTFLVSATSSDDEFNYSYL
                     LDEYEEIVETSLITRYESEDNYFYLLNQGTPTNFVVNSALGNYILLVQAAILYTAKKFI
                     EDREMAIAKQVNTLSDEDNYNIAKQWLEEFC"
     CDS             4864..6072
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 278.7; E-value: 1.3e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg36_4"
                     /transl_table=11
                     /translation="LNKKEQQNTYLLVGSRIISRVGDIMFDFANNTFLSSVNVKSLMLV
                     GIYQTLENIISVIFNLFGGVLSDNFQRKRIIILTDILSGVLCLALSFISNQQWLIYAVV
                     ITNIILAFFSSFSGPAYKAFTKEVVEADNISKLNSLLESFITVVKVVVPLVSVSLYGLL
                     GLYGILRLDGITFIASGLLILFIRPILEESTGKQVFSLSKIFSDLFEGGRYLASQKEIL
                     YLVILSAIVNFFLAAYNLLLPYSNQMFPRVTVGLYGVFLGAEAVGGLIGASLSSILNKV
                     LKIKTMILYLGVSGVFLSLTPMVYCVFPSAYMLALYPALFNLFLTMFNLQFFSYIQKNV
                     DNVFLGRVFGIIFTVAILFMPIGTMTFTFLLSPKNIFNFVIVGLSIGGISLLFYRIFSK
                     RLR"
ORIGIN
        1 acgtttggaa gaactccaaa aagatggtac tttggctaag ttggctgaaa aattctttgg
       61 aaataaagat tatattccaa ctaaagacgc tttgaaagtt ccaagtaaaa aataagaaag
      121 gctctttgtc aactgtagtg ggtgacgaaa agcctttgtt tatcatatga taaacaaaag
      181 agggaaatga tgaaaaaggt aaaatttttg ccaactttga aaattgcttt tgaaattctt
      241 attgttgtgt gtggataaat tatgaatgac agtgcataat caatcaaatt aaggagaaga
      301 gaaatgacca tattaaaaac ttttagtgat acggtgaaac aatatccttc taaagttgct
      361 gttatgtata gcggaggaga gtttactttt caagaagtag atgtgatgtc taattttatt
      421 gctaagcagc tactactcaa tagcgatgaa gagactgtac ctttttatat agaaaaaaat
      481 aagtatgttt taccagttgt tttggggata atgaaatcgg gtaaaattcc gttacctata
      541 acaaatagtc ttgaggtcaa aatatcatta gaacgtatta gcgaagttgt ctttgacgtg
      601 ttgataagtg atagggatgt taaacttgaa aatcattcag taactctttt ggtcttaccc
      661 aaaaaattag aaagttacag tgagtatcaa gaagtagcta caactaaaga gaatgaaatt
      721 gcacatatta tctgtacttc tggaactact ggggttccta aaaaagtatt tttaactgat
      781 gataacatag attggcttgt aaaagaattt tataaaattg tgaagtttac ttccgaatca
      841 aaatttttat ttacaactcc ctatactttt gatgtttcat taacagagat tttggcacct
      901 gtatatacgg gtggtacttt ggtttgttac gatggtggga ttcagaatat tattcgacta
      961 ggagaaacaa ttgagcaaaa gaagataact catttatcat tatctccgtc ttttgctgaa
     1021 actattattg atattagtgg gccagaagta ttccagaatt taagagcgtt gtgtctagca
     1081 ggtgagacat ttcctagttc attagcgaat aggttgagag ggcttattca gcaagggtgt
     1141 cgagtattta atttatatgg gccttcagaa acaacaattt atgcaaccta ctatgagttg
     1201 aaagatagaa aatataatac tgttccaatt ggtaagcctt tgcctggggt tcaactaaag
     1261 atagcttctc aaaaagagaa ttctaagatg gcagaacttc taattggtgg taatggagta
     1321 acggaagggt atagactaca acccgaatta aataaagcta agtttaagtt gataggttca
     1381 aataggtact atgtaacggg ggactacgtt tattaccaag gagataactt ggtatttagt
     1441 tcaagaatag atagccaagt ccaagtaaat ggtattcgta ttgaattaga tgaggtaaaa
     1501 tctattgtag ataaacttaa aacagttaaa tcatcacgag ttgtttttta taagaagaaa
     1561 cttgtcgtat tttatgaagc cgatttgaat attaaagaag atattattag aagtttacct
     1621 agttacttaa atccgacggt agttaaagtt gagagttatt atctcaatca gaatagaaag
     1681 ttggatgttc caaaaatgct tgagatatat tattataaaa aacaaagtca acaaggagat
     1741 gatgttagaa aaaatatttt agatgtacta tctaaatttg aaagagttga tatcacagat
     1801 ttggattcgt tagaattggt tagattttat ttagagattg aggatatctt tgatattgaa
     1861 attaaagaaa atgattttta taggctaaag agtgtagatt cgattgtgga ctatattaga
     1921 aataaatcat tttttcaaga acgttcaact gagccaaacg atagttttac taaagaacat
     1981 gacttggtta atttagagta taatctcaca aaaatgaatt atcgttattt gaaaaatatt
     2041 attactccta gcccgacaca aaagagactt tataaaaaca atcaaaatcg tgttattggt
     2101 tttaatttag cactggaaga agtgacttat ttagaattga ataagctgca ccatattatt
     2161 aaatatttaa gctataaaat tgatatattt agacttgttg tcgaaaagga gcaaactcga
     2221 tttagcatag gtattgtgaa tgaaggagat tactcaccta atattattgt actaaataat
     2281 ttaccaacag agttagaatt acaaggaata ttagataata tagaagtgat tcctattcca
     2341 attattgtgg tgggaacaag agataaaaaa gtaagatttt attttccata tcattctatt
     2401 gatgcatcat cattaaataa acttggagat acagtatatc aactgtacga aaaaaagata
     2461 gttattgatg aagtacctag tagttcactg gttgcttttt cgcagtttaa aagggaggtg
     2521 ttacagaatg atgtctctgg ggatgttctt gctagattgc caaagataaa gcctgctatt
     2581 gagtttgaga aattaaatga tgaagttcaa tgttttcaag tttctttacc agaagatatt
     2641 aaaggagacg atgtatatct ttttacaatt tatgctatct cacagtgtat tttaagcgac
     2701 tataatctgt ctgctatatc tgggggtcta tctttggatt ttagagatta tgaacagttt
     2761 gatgcgtatg acttaatagg agacattcac aagaaaattc cattccaagt aaatcgaact
     2821 gaaacttttg aggagtttaa aaactctcat ttcaaaattt tggagatcta tcgtacaggt
     2881 attgattact atgaaattgc aatgttagga aatgatatga gtgctaaaga agtgcaagaa
     2941 cgattaaata atctgtctct atcaataaat ttcattggcg aagcatttag gttaaaagat
     3001 actattaata atataattga tgttgatttt gataaaaatt ttattaatgt atttgtacat
     3061 gagcgatttg catacgcagt tataaaatct gagttattga gtaatagtgt ttatgactta
     3121 atgcataaag atagcaaatt cgagctaaaa gtaattgata aaaaacgact ggaaaatgag
     3181 gagacaaacc gatgagtatt tataaagata tagtagaggg gtaccaactg aataatattc
     3241 aggaaaagga taaattgaat aacgttttgg tacagcttaa tgaaaaagat gatcaagaga
     3301 tgataaatag aaagaatttc attgggcatt ttacagcatc agcatttgtt atttcaaaag
     3361 ataacaggcg tttattgatg gttcaccata atattttaaa aagataccta cagcctgggg
     3421 ggcatattga taaaaatgat agaaacccgc tagatgcagc gaaacgtgag ctgtttgagg
     3481 agactgggat agattctgaa atattgacgt atcaatgtgc agaaccattg aatagcttga
     3541 taccttttaa tgtttctgtg cataagatac cagaaaataa attgaagaat gagcgttccc
     3601 actaccatta tgacttgcaa tatttatttt atattgaaaa tgaggttgat gtgaaaattg
     3661 acagcaacga atcgagttcc tatgagtgga ttcagctaga taatgtaaag gacatggacg
     3721 gctataagga aatcattaag aagattgaaa aacttgaagc agcttctcaa gaacgttttt
     3781 tatctaatat gctgaaaggt gcatcgtttg aagacatatc atgtattact gtacaacata
     3841 ttattccaag tacaataccg attatcatga cattgcaaaa aatatttggg catcgtttgt
     3901 tagtgtgtgc taaaccaaac tctgttgata agatggtatg gcacaagcta gaaaatatgg
     3961 gggtaagatt aacattagct tcaagggatg aatattttaa tgtagattat ctggggataa
     4021 agagtaaaac aattttatta gacattggtg ggtattttgc ctcaattgct cagattccaa
     4081 acttacctat cgagtgtatc attgaagata cagaaaatgg gattcaaaaa tatgagaatg
     4141 ttattgatca aatagaatat ccgttatttt ctgtcgctag aaatcccctg aagaagaatg
     4201 aggattactt agttggtgcg gatattgttt ttgggacaga ttatatatta catcaaaaaa
     4261 atttattaat gcaatatatg caagtggttt gtattggata tgggaaaatc ggttacggca
     4321 tctgtaccaa attaagagaa cttggtatta gaccgaaggt gctggaaaaa gatagcatga
     4381 gaactattca agcggtacgt gatggttgcg acattttgct agaaaaagat ttcaagaata
     4441 ttgatttgat tttttgtgcg accggttcaa aaagtctaga tattttagat tttcgctcta
     4501 tcaaagatgg aaccttccta gtctctgcaa catctagtga tgatgaattt aattatagct
     4561 atttattgga tgaatatgaa gaaatagtcg aaacttcatt aatcactaga tatgaaagtg
     4621 aagacaacta tttctatctg ttaaatcaag gaacaccaac taattttgta gtaaactccg
     4681 ctttgggaaa ttatatttta ttagtccagg cagccattct atatacagct aagaagttta
     4741 ttgaagatag agaaatggct atagctaagc aagtaaacac tctttcggat gaggataact
     4801 ataatattgc gaagcaatgg ttagaagagt tctgctaatg aacaaatatc tgaggagttt
     4861 attttgaata aaaaagaaca acaaaataca tatttacttg tagggagccg tattatttct
     4921 cgtgttggag atattatgtt tgactttgcg aataacactt ttttatcgag tgtaaatgtt
     4981 aagtcactta tgttagttgg tatttatcag acattagaaa acatcatcag tgtgattttt
     5041 aatctttttg gtggtgttct gtctgataac tttcaaagaa aacggattat cattttaaca
     5101 gatattttaa gcggagtatt gtgtcttgcc ttatctttta tttctaatca gcagtggttg
     5161 atttatgctg tggttatcac aaacattata ttagcttttt tctcatcatt ttcaggccct
     5221 gcttataagg cttttactaa agaagtggtg gaagcagata atatttcaaa actaaactca
     5281 ttactagaat cgtttataac ggtagttaaa gtcgttgttc ccctggtatc ggtatctcta
     5341 tacggtttac taggattata tggtatttta cgtctagatg ggataacatt tattgcatct
     5401 gggttgctta ttctctttat tcgtcccata cttgaagaaa gtactgggaa acaggtgttt
     5461 tcattatcga aaatcttttc agatcttttt gaaggaggaa ggtatctagc tagtcaaaag
     5521 gaaattttgt acttggttat tttatctgcg attgttaatt tctttttagc agcttataat
     5581 ctgttgttac catatagcaa tcagatgttc ccaagagtta ccgttggctt atacggtgtt
     5641 ttcctaggag cagaagcagt aggtggtctt attggagcgt ctttaagcag tattctcaat
     5701 aaagttttga aaataaaaac aatgatttta tatcttggag tatcaggtgt ttttctatct
     5761 ttgacaccta tggtatactg tgtttttcca agtgcttata tgcttgcgtt atatcctgct
     5821 ttattcaact tgtttttgac tatgttcaac ttacagtttt tttcatatat ccaaaagaat
     5881 gtggataatg tctttcttgg tagagttttt gggattattt ttactgttgc aattttattt
     5941 atgcccattg ggacaatgac atttactttt cttttaagcc ctaaaaatat ctttaatttt
     6001 gttatcgttg gtttatctat aggaggtatt tcgcttctct tttataggat ttttagcaaa
     6061 agattgaggt aaattttcag agtaatttta gctccgatgg cgtagtaaaa ttgcttagta
     6121 aagtcacaat ttatatactt gttagggcaa ccattacaca cataaggtaa tcgttttaga
     6181 agtgggcggg cctcacattt tgagtgttga ttgattcctt gatggtaagg tgtttacata
     6241 cttttttaga gacagtagat gggtcgccga ttagtttaga aatagctcta aatgtcttgt
     6301 tcgtttctca taaaagtcag cgatattgca gggattggta tgactagctg aagcgatgtt
     6361 gtgaatgtac ttgaacaaga ttttactggc atagggattc cctcgtttag tgatgtgttc
     6421 cttagcgaga aagttcccag attcatagtg tctcaggtca atgccaataa aagcgttgat
     6481 ttgattggta tactgcgacg aatatctccc aattcgccaa tgatagatgt cgctgtggtt
     6541 tctgcgatgc caggaattga ccgtaagatg tcatactctg gtaaaggctg agctagagct
     6601 accatgtcgt ttaagacaac ccgtctgcgt tcagaaagac gaagcaattc ggctctttgt
     6661 caaacaattg atatttttag gtgatagtat tttcttatca ctttgatt
//
