LOCUS       c00004_JAIQWO0..       15310 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWO010000013.1 Streptococcus thermophilus strain CF8_14
            NODE_13_length_53722_cov_21.344122, whole genome shotgun sequence.
ACCESSION   JAIQWO010000013
VERSION     JAIQWO010000013
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 04:35:14
            Original ID  :: JAIQWO010000013.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15310
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15310
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[199:5310]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      200..5310
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15310
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15310
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2..124)
                     /locus_tag="ctg4_1"
                     /transl_table=11
                     /translation="MNFRNISVIPKNDFLVSKLFKQKGSIISVVGKTTVEIIELF"
     CDS             200..1909
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2"
                     /sec_met_domain="ILVD_EDD (E-value: 2.3e-221, bitscore:
                     727.9, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKVGVDKAPARGLLYATGQVKSSKDMQKPFIAICNSYIDIVPGH
                     VHLRELADIAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSRELIADAAETVIN
                     AHWFDGVFYIPNCDKITPGMILAAMRTNVPAVFCSGGPMKGGVDMTGHQATLSSLFEAV
                     GTYQSGDMSKEELDYLEKNACPTCGSCSGMFTANSMNCLMEVLGLALPGNGTILAVSDE
                     RRELVRQAATKLMDNIKNNVRPRDIVTKEAIDDAFALDMAMGGSTNTVLHTLAIAREAG
                     IDYDLKDINDIAKKTPYLSKIAPSSIYTMHDVHEAGGVPAIINQLIKKGAIKGDRITVT
                     GKTLKENVAGAKIKNEEIIHPIEQPILPVGGLSILYGNIAQDGAVIKVGGVDPSVKTFR
                     GKAICCDSQAQALELIDNGTVKKGHVVVIRYEGPQGGPGMPEMLAPTSKIVGRGLGKDV
                     SLITDGRFSGATRGIAIGHVSPEAAEGGNIALIEDGDEIVIDLPNRTLDLLVDDVTLEA
                     RRKHLNPFKSKISSGWLRRYTAFAKSANIGGTLMSNEEFEERKAERQAQEKN"
     CDS             2043..3743
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.7e-47, bitscore:
                     150.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VEKIELEEARSGADLILDTLLELGISTIFGYPGGAVLPLYDAIYK
                     NEEINHILSRHEQGSLHEAEGYAKSTGKLGVALVTSGPGATNAITGIADAMSDSVPLLV
                     FTGQVATSGIGKDAFQEADIVGITIPITKYNYQIRDTADIPRIIREAVHIATTGRPGPV
                     VIDLPKDVVAKETTFINDPEINLPSYQPTLRPNEMQINKILKQLGKAKKPVIVAGGGVA
                     YSESAKELVAFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSYAANIAMTDADFMI
                     AIGCRFDDRLTGNPKTFAKNAKVVHIDVDPAEIGKIIAVDLPVVGDAKQALEMLLAEPV
                     VKNNTEKWIEKVKKDKERVRSYDKKERMVQPQAVIERIGELTDGDAVVVTDVGQHQMWT
                     AQYYPYQNERQLVTSGGLGTMGFGVPAAIGAKIANPDKEVILFVGDGGFQMTNQELAIL
                     NIYKVSIKVVMLNNHSLGMVRQWQESFYEGRTSESVFNALPDFQLMAQAYGIKSYKFDN
                     PETIDQDLEVIKEDVPMFIEVDISRKEHVLPIVPAGKSNHEMLGVKFNA"
     CDS             3736..4212
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_4"
                     /sec_met_domain="ALS_ss_C (E-value: 2.3e-28, bitscore:
                     90.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATENPDVSR
                     ITIIIDVNSHNEVEQIIKQLNRQIDVIRIRDITDVPHLEREVILVKVSAPTSKRAEILA
                     IIQPFRASVVDVAPSSITIQMTGDAEKSEALLRVIRPYGIKNIARTGATGFTRD"
     CDS             4288..5310
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_5"
                     /sec_met_domain="IlvN (E-value: 6.5e-77, bitscore: 248.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.8e-65, bitscore: 211.1,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQMEYEKDVKVPALDGKKIAVIGYGSQGHAHSQNLRDTGHDVI
                     IGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAV
                     GFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKD
                     IAMDWCKGIGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIETGFEVLTEAGYAPE
                     LAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEFGDYVSGPRVITEQVKENMKAVLAD
                     IQNGKFANDFVNDYKAGRPKLTAYREEAANLEIEKVGAELRKAMPFVGQNDDDAFKIYN
                     "
     CDS             complement(5436..6692)
                     /locus_tag="ctg4_6"
                     /transl_table=11
                     /translation="MTIFEELKARGLIFQTTDEEALVKAFEEGPVSFYTGYDPTADSLH
                     LGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFNDAERSLQTKETVEGWVEKIQGQ
                     LSRFLDFENGDNKAVMVNNYDWFGSVSFIDFLRDVGKYFTVNYMMSKESVKKRIETGIS
                     YTEFAYQIMQGYDFYELNAKYGVTLQIGGSDQWGNMTAGTELLRRKADKSGHVITVPLI
                     TDSTGKKFGKSEGNAVWLDATKTTPYEMYQFWLNVMDDDAVRFLKIFTFLSLEEIEEIG
                     KEFDQARHQRLAQKVLAREVVTLVHGKEAYEQAVHITEQLFAGNLKALSARDLKVALNG
                     VPTYEISADENLNIVELLVNAKISPSKRQAREDVQNGAIYINGERVQDLDYTLSDTDKI
                     DNEITVIRRGKKKNFVLTY"
     CDS             6961..9216
                     /locus_tag="ctg4_7"
                     /transl_table=11
                     /translation="MTLLDMGDVFLKTLKLLSDFFYVVIIVLTLFGAGIGLGYLGSQIQ
                     SVPLIKDKTLLNQIGEVSLVSSMSYSDSKKIADIDTDLLRTPIESDAISNNVKNAIIAT
                     EDENFNKHKGVVPKAVFRALVSSVLGVGSSSGGSTLTQQLIKQQVTGDTPTFKRKAAEI
                     IYALQLERHASKNEILTDYLNVSPFGRNNKGKNIAGIEEAAQGIFGVSAADLTVPQAAY
                     LAGLPQSPIVYSPYTADGQLKNEKDLSYGLARQKDVLYNLYRGGYLDKSQYESYKSYDV
                     TKDFKAGENPDAVSHDYLYYSVMSEAQDIMYDYLVKRDKVSSQDLKNDKTKEAYREMAL
                     RELQTGGYHVKTTIDNAVYHAMQDTANKYGDLLDQGGNNGVEVGNVLMDNATGAILGFV
                     GGRNYENNQNNHAFDTARSPGSSIKPIIAYGIAIDQGLMGSSSILSNYPTNFTGGTPIL
                     HDGDKGTAMMNLQEALNTSWNIPAFWTYQMLQHHDVDVEGYMTKMGYKIANYNIESLPL
                     GGGIETTVAQQVNAYQMLSNGGVYEKGYMIDSITDSTGEVIYQHKSKGVQVFTRATASI
                     MDNLLKEVVVKGATTQFYSELKNVNGAAASADWMGKTGTTDNFADAWLVVSTPGITLGG
                     WAGYDDNAPTNSKMGYTYNAQYMARLTSAIYNANPGIFKTGDKFNIDSSAIKASVLKST
                     GLKPATVSVNGRNVSVSGEMVDSYWAKNGPGDTIYKFAIGGTDSDYQKAWSSILGEH"
     CDS             9579..13160
                     /locus_tag="ctg4_8"
                     /transl_table=11
                     /translation="LAGHDVQYGKHRTRRSFSRIKEVLGLPNLIEIQTDSFKEFLDTGL
                     KEVFEDVLPISNFTDTMELEFVGYELKEPKYTLEEARIHDASYSAPIFVTFRLINKETG
                     EIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVI
                     PNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIVDIFGDSELVRNTIE
                     KDIHKNPADSRTDEALKEIYERLRPGEPKTADSSRSLLVARFFDPRRYDLAAVGRYKLN
                     KKLNIKTRLLGQTIAENLVDPETGEILVEAGTEMTRDVIDSIAEHLDGDLNKFVYTPND
                     YAVVTEPVVLQKFKVVAPNDPDRVVTIVGNANPDDKVRALTTADILAEMSYFLNLAEGI
                     GKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNEALTPQQIINIRPV
                     TAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGR
                     MCPIETPEGPNIGLINNLSTYGRLNKYGFIQTPYRKVDRATGKVTNEVVWLTADEEDEY
                     IVAQANSKLNEDGTFAEEIVMGRHQGVNQEYPSHLVDFVDVSPKQVVAVATACIPFLEN
                     DDSNRALMGANMQRQAVPLIDPKAPFVGTGMEYQAAHDSGAAVIAKHDGKVVYSDADKV
                     EVRREDGSLDVYTIQKFRRSNSGTAYNQRTLVKVGDIVEKGDFIADGPSMEGGEMALGQ
                     NPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEFESETRDTKLGPEEITRELPNV
                     SEEALKNLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDT
                     SLRVPHGGDGVVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGV
                     VSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIYIATPVFD
                     GASSEDLWDTVREAGMDSDAKTILYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARS
                     VGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNILQEILTYKSDDVNGRLKAYE
                     AITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDYEVELRDLDEGEDDDVMHVDD
                     LEKARVQQAKEAAELEKAKEEALDKTE"
ORIGIN
        1 caaaaagctc tataatctct acagtagttt tacccactac agaaattata gagccttttt
       61 gtttaaatag tttcgatact aaaaagtcat tttttggaat tacagaaata ttccgaaaat
      121 tcattgacat taccttccaa agtggtaaca tatgttgtaa gaaattttat agattgaagg
      181 taagatcatg agaagtgata tgatcaaagt tggtgttgat aaagcaccag cacgtggcct
      241 tttgtatgcg actggacagg ttaaatcttc taaggatatg caaaagccct ttattgctat
      301 ttgtaattct tatattgata ttgttccagg acatgtccac ctacgtgaat tagcggatat
      361 tgccaaggag gctatccgtg aagctggtgg tattcctttt gagtttaata ctattggtgt
      421 ggatgacggg attgccatgg gacatattgg gatgcgttac agcctccctt cacgagaatt
      481 aattgctgat gctgcagaaa ccgttattaa tgcccactgg tttgacggtg tgttctatat
      541 cccaaactgt gataagatta caccaggaat gattttggca gccatgcgta ctaatgtgcc
      601 ggcggtattc tgttcaggtg gacctatgaa gggtggcgtt gatatgactg gtcatcaggc
      661 tactttatca agcttgtttg aagctgtagg tacttaccag tctggagata tgagcaagga
      721 agagcttgat tatttagaga aaaatgcctg tccaacttgt ggttcatgtt caggaatgtt
      781 tactgctaac tcaatgaact gtttaatgga agttttgggt cttgcccttc caggtaacgg
      841 tactatccta gctgtttcag acgaacgtcg tgaattggtt cgtcaagcag ccacaaaatt
      901 aatggataac atcaaaaata atgttcgccc acgtgatatt gtgaccaaag aagccatcga
      961 tgatgctttt gctctagata tggctatggg tggttcaacc aataccgttc ttcataccct
     1021 tgctattgcg cgtgaggctg gtattgacta tgaccttaag gacattaatg atattgctaa
     1081 gaagacacct tatctctcta aaattgctcc ctccagcatc tataccatgc atgatgtaca
     1141 tgaagcaggt ggtgttccag ccattattaa tcagttgatc aagaaaggtg ccattaaggg
     1201 tgatcgtatt acggttactg gtaaaacctt aaaagaaaat gtagctggtg ctaaaatcaa
     1261 aaatgaagaa attatccatc caatcgagca acctatttta ccggttggcg gtttgtctat
     1321 cctttatgga aatattgctc aggatggggc tgttatcaag gttggtggtg tagatccatc
     1381 cgttaaaact ttccgtggta aggctatttg ttgcgattca caagctcaag ctcttgaatt
     1441 gattgataat ggaacagtta agaagggcca tgttgttgtc attcgttacg agggtcctca
     1501 gggtggtcct ggtatgccag agatgttagc gccaacctct aagattgtag gccgcggtct
     1561 tggcaaggat gtttctctga ttactgatgg tcgtttctca ggagcaactc gtggtattgc
     1621 tattggtcac gtatctccag aagctgcgga aggtggcaat atagctctga ttgaagatgg
     1681 ggatgaaatt gtgattgatc ttccgaatcg tacccttgat ttgctcgttg atgatgtgac
     1741 acttgaagca cgccgtaagc acttgaaccc tttcaaatct aagatctcaa gtggctggtt
     1801 acgccgttac actgcttttg ctaaatcagc taatatcgga ggaactctta tgagtaatga
     1861 agaatttgaa gaacgtaaag cagaacgtca ggcacaagaa aaaaactaag aatattattt
     1921 ccgaagagtt tgtgatattt ttctctgaaa cccttgcaaa tttagttaaa aatgttagta
     1981 tagtatacaa ggttttgaat ttttagataa tttgaaaaaa acaattgcta aaggaggtcc
     2041 atgtggagaa aattgaactt gaagaagcac gctctggtgc tgatttgatt cttgatacac
     2101 ttctcgaact tgggatttca accatttttg ggtatcctgg cggagcggtt cttcctttgt
     2161 atgatgctat ttacaaaaat gaagagatta atcatatttt gtctcgtcat gagcaaggaa
     2221 gcctgcatga agctgaaggt tatgctaaat caactgggaa acttggtgtt gctcttgtaa
     2281 cgagtggtcc cggtgcaacg aatgctatta ctgggattgc agatgctatg agtgatagtg
     2341 tacctcttct ggtctttacg ggtcaggtag caacatcagg tattggtaag gatgccttcc
     2401 aagaagctga cattgtcgga attaccattc caattaccaa atacaactac cagattcgtg
     2461 atacggctga tattcctcgt attattcgag aagcggttca tatcgcaacg acaggacgtc
     2521 ctggtccggt tgttatagac cttccaaaag atgttgtagc taaggaaact accttcatca
     2581 acgatcctga aatcaatctt ccaagttacc aaccgacgct aagaccaaac gagatgcaaa
     2641 ttaataaaat cttgaaacag ttgggtaaag ctaagaagcc ggttattgta gctggaggtg
     2701 gagtggctta ttctgaatct gctaaggagc tagttgcttt tgcagaacgc taccaaattc
     2761 ctgttgttac aagtcttcta ggtcagggaa caattgctac tagtcatccc ctctttttgg
     2821 gtatgggtgg tatgcacggt tcgtatgcag ctaatattgc tatgactgat gctgacttta
     2881 tgattgccat aggttgtcgt tttgatgacc gcttgacagg taatccaaaa acatttgcta
     2941 agaatgcaaa ggttgttcat attgatgtgg atccggctga gattggcaag attattgcgg
     3001 tagatttgcc agttgttggt gatgccaagc aagctcttga aatgctctta gcagaaccag
     3061 tggttaagaa taacactgaa aaatggattg aaaaagtcaa aaaagataaa gagcgtgtac
     3121 gttcttacga taagaaagaa cgtatggtac agcctcaggc ggttatcgag cgtatcggtg
     3181 aattgaccga tggtgatgca gttgttgtca ctgacgttgg gcaacatcaa atgtggacag
     3241 ctcagtatta tccatatcaa aatgagcgtc aattggtgac atcaggtggc cttggaacta
     3301 tgggatttgg tgttccagca gcaattggtg ctaaaattgc taatcctgat aaagaagtta
     3361 tcctctttgt tggtgatggt ggtttccaaa tgacgaacca agaattggct attttaaata
     3421 tttacaaggt gtcaatcaag gttgttatgt tgaataacca ctcacttggt atggtacgtc
     3481 aatggcaaga gtccttctac gaagggcgta catcagagtc tgtctttaat gctctccctg
     3541 attttcaact gatggctcaa gcttatggga ttaagtctta taagtttgat aatccagaaa
     3601 cgattgatca ggatttggaa gttatcaaag aggatgtgcc aatgttcatc gaggttgata
     3661 tttctcgtaa agagcatgtt ttgccaattg ttccagctgg taagagtaat catgaaatgt
     3721 tgggggtgaa gttcaatgcg tagaatgtta acagctaaac ttcagaaccg atcaggtgtt
     3781 cttaaccgtt tcactggagt gctttcacgc cgtcaggtca atattgagag tatttccgtt
     3841 ggagcaacgg aaaatcctga tgtttcacgt attacaatta tcattgatgt gaattctcat
     3901 aatgaggttg agcagattat taaacagctt aatcgtcaga ttgatgtgat tcgcattcgt
     3961 gacatcactg atgtacccca cttggaacgt gaggttatct tggttaaggt gtcggcacca
     4021 acttctaaac gtgctgaaat cttggcaatc attcaacctt tccgtgcttc ggtggtggat
     4081 gttgcaccaa gctctatcac tatccagatg actggagatg ctgaaaagag tgaggcgctt
     4141 ctacgagtta ttcgacctta cggtatcaag aatattgctc gtacgggtgc tactggattt
     4201 acccgtgatt aaaaaatcca ttataaattt gttaacctag ccttaaaaag gcaattaaat
     4261 attattttag aaaagagata tactactatg gcagttcaaa tggaatatga aaaagacgta
     4321 aaagtaccag cacttgatgg taaaaaaatc gccgttatcg gttacggttc acaaggtcac
     4381 gctcactcac aaaacttgcg tgatacaggt cacgatgtta tcatcggtgt tcgtccaggt
     4441 aaatcatttg ataaagctaa agaagatggt tttgatactt acacagtagc agaagcaact
     4501 aaattggctg atgttatcat gattttggct ccagacgaaa tccaacaaga actttacgaa
     4561 gcagaaatcg ctccaaatct tgaagctggt aacgctgttg gttttgctca cggtttcaac
     4621 atccactttg aatttattaa agtaccagca gatgttgatg tatttatgtg tgcacctaaa
     4681 ggaccaggtc acttggtacg tcgtacattt gaagaaggtt ttggtgtacc tgccctttac
     4741 gcagtatacc aagatgccac aggtaacgct aaagacatcg ctatggactg gtgtaaaggt
     4801 attggtgcag cacgtgtagg tcttcttgaa acaacataca aagaagaaac tgaagaagat
     4861 ttgtttggtg aacaagcagt tctttgtggt ggtttgactg cccttatcga aactggtttt
     4921 gaagtcttga ctgaagctgg atatgcacca gaattggctt actttgaagt acttcacgaa
     4981 atgaaattaa tcgttgactt gatttacgaa ggtggattca agaaaatgcg tcaatcaatt
     5041 tctaacactg ctgaattcgg tgactatgta tcaggtccac gtgttatcac tgaacaagtt
     5101 aaagaaaaca tgaaagcagt tcttgctgat atccaaaatg gtaaattcgc taatgacttc
     5161 gttaacgact acaaagctgg acgtccaaaa cttactgctt accgtgaaga agctgctaac
     5221 cttgaaatcg aaaaagttgg tgctgaattg cgtaaagcaa tgccattcgt tggtcaaaac
     5281 gacgatgatg cattcaaaat ctataactaa tgtgatagtc tcaaaaacca gcctagtgct
     5341 ggttttttgt gttcttaaga aagtgattag gtgttaagct tatggctttg tgtgtaaaaa
     5401 aaatcactcc actagggagt gagaatggtc ataaattagt aagttaaaac aaagtttttc
     5461 ttcttaccgc gacggataac agtgatttca ttgtcaatct tatcggtatc tgaaagagtg
     5521 taatccaagt cttgcacgcg ttcaccgttg atatagatag caccgttttg cacgtcttca
     5581 cgtgcttgac gtttagatgg tgaaatttta gcattgacga gaagttcaac aatgttaaga
     5641 ttttcatctg ctgaaatctc ataggttggg acaccattga gggcaacttt aaggtcacgt
     5701 gctgagaggg ctttaaggtt accagcgaag agttgttcgg tgatgtgaac agcttgttca
     5761 taggcttctt taccgtgaac caaagtaaca acttcgcgag ccagaacctt ttgtgctaaa
     5821 cgttggtgac gagcttggtc aaattcttta ccgatttctt cgatttcttc aagtgacaag
     5881 aaagtgaaaa ttttcaagaa acgaacggca tcatcgtcca taacgttaag ccagaattgg
     5941 tacatttcat aaggagttgt cttagtagcg tcaagccaga cagcgttgcc ttcagatttg
     6001 ccgaattttt taccagttga atctgtgata agtggaactg tgattacgtg tccagattta
     6061 tccgctttac gacgcaagag ctcagtacct gctgtcatgt taccccattg gtcagaacca
     6121 ccaatttgta gggttacgcc atatttagca ttgagttcat agaagtcata accttgcata
     6181 atttggtaag cgaactcagt gtaagagata cctgtttcga tacgtttctt aacagattcc
     6241 ttgctcatca tgtagttaac tgtgaagtat ttaccgacat cacgcaagaa atcgatgaag
     6301 ctgacagaac caaaccagtc ataattgttg accataacgg ctttgttgtc accattttca
     6361 aaatcaagga aacgagagag ttgtccttgg attttttcta cccaaccttc aacggtttct
     6421 ttggtttgga ggctacgctc agcatcatta aatgatgggt caccaatcaa acctgtcgca
     6481 cccccaacga gggcgtaagg tttgtggcca gccaattgaa ggcgacgact agtaaggata
     6541 gcgacgaggt gtccaaggtg gagactgtct gctgttggat cataaccagt gtagaatgag
     6601 actggccctt cttcaaaggc ttttacaagg gcttcttcat ctgtggtttg aaaaatcaag
     6661 ccacgtgctt ttagttcttc aaaaattgtc atgatattct ccagtaaagt atattctgca
     6721 ccattatacc aaaagaagca accctatgca agctttgtca aagtttgtta taataggctt
     6781 tgaggtattt ctatgaattt tgaaaaaata ataaattatt ttaggcgact agggcagact
     6841 attcgtacaa agtttgctgg ttctaggtct aaaagaggag ataaatcttt taaagaaagg
     6901 aaagctacga ctggattcaa gtggaatcgt aagcaagcac ggaagtcgcc tgaggatggg
     6961 atgacactct tagacatggg tgatgttttc ttaaaaacct taaagctctt gtctgatttc
     7021 ttttatgtgg ttattatcgt tcttacccta tttggtgcag gaattggttt gggttatctg
     7081 ggcagtcaga tacagtctgt tccattgatt aaggataaaa ccttgttgaa tcagattggc
     7141 gaggttagtt tggtgtcttc gatgagttat tctgattcta aaaagattgc tgatattgat
     7201 acggacctgc ttagaactcc tattgaaagt gatgcaattt ctaataatgt taaaaatgcc
     7261 attattgcta ctgaggatga aaatttcaat aagcataagg gggttgtacc aaaagctgtc
     7321 tttagagcct tggtatcctc agtcttgggg gtaggttcct ctagtggtgg ttcaacccta
     7381 acacagcagt tgataaaaca acaggttaca ggagatactc caacatttaa acgtaaagcg
     7441 gcagagatta tctatgcact acaactggaa cgtcatgctt cgaaaaatga aattttaact
     7501 gattatctga atgtttctcc ttttggtcgt aacaacaagg ggaaaaatat tgctggtatc
     7561 gaagaggctg cacaagggat ctttggggtc tctgctgcag atttgacagt tcctcaggca
     7621 gcttatctgg caggtttacc acagagcccg attgtctatt caccctatac tgcggatggt
     7681 caactaaaaa atgaaaaaga tctttcctat ggcttggcac gtcagaaaga tgtgctctac
     7741 aatctctatc gaggcggtta cctagataag tcacaatacg aaagttataa gagttatgac
     7801 gttactaaag atttcaaggc tggtgagaat ccagatgctg tcagtcatga ctatttgtac
     7861 tattcagtca tgtctgaagc tcaagatatc atgtatgatt atttggtgaa gcgtgacaag
     7921 gtatcaagtc aagatttgaa aaatgataag acaaaggaag cctaccgtga gatggctctc
     7981 cgagagctac aaacaggtgg ttatcatgtt aagacaacaa ttgacaatgc tgtctaccat
     8041 gcgatgcaag atactgcgaa caaatatgga gatctacttg atcagggtgg aaataacggg
     8101 gtcgaagttg gaaatgtact catggacaat gcgactggag cgattttagg atttgttggt
     8161 ggtcgtaatt atgagaataa ccagaataac catgcctttg atactgctcg ttctcctgga
     8221 tcttctatta agcctattat tgcttatgga attgccattg accaaggttt aatgggtagc
     8281 tcaagtatcc tttcaaatta tccaactaat tttacaggtg ggacaccgat tcttcatgat
     8341 ggcgataagg gaacggccat gatgaatttg caagaggcgc ttaatacgtc gtggaatatt
     8401 cctgcctttt ggacctatca aatgcttcaa catcatgatg ttgacgttga gggctatatg
     8461 accaagatgg gatataagat tgctaactac aatattgaga gtctgcccct tggtggtggg
     8521 attgaaacta ctgttgctca gcaggtaaac gcctatcaaa tgctttcaaa tggcggtgtt
     8581 tatgaaaaag gttatatgat tgatagtatt actgatagca ctggtgaggt tatttatcaa
     8641 cataaatcta aaggggttca ggtctttaca agggctacgg ctagcattat ggataactta
     8701 cttaaagaag ttgtggttaa gggagcgaca acccaatttt attcggagtt gaaaaatgtc
     8761 aatggtgcag cggcctcagc tgactggatg ggtaaaacag ggacaactga taactttgct
     8821 gatgcttggt tggttgtgtc gacgcctggc attacccttg ggggttgggc tggttatgat
     8881 gacaatgcac ctaccaattc taaaatgggt tacacttaca atgcccaata tatggctcgt
     8941 ttgacttcag ccatctataa tgctaatcca ggtattttca aaacgggaga taagtttaat
     9001 atagattcaa gcgccattaa ggcaagtgtg ctcaagtcga caggccttaa gccagcaacg
     9061 gtatcggtca atggccgtaa tgtctccgta agtggtgaaa tggttgatag ttattgggct
     9121 aaaaatggac ctggcgatac aatctacaag tttgccattg gtggaacgga tagtgactac
     9181 caaaaagctt ggtctagtat tcttggagaa cattaggctg tctcaaataa tacttgcaaa
     9241 atagttaaaa tttaggtaca atatagacaa aactatttgt cgtcttattt gattgaaata
     9301 ttgtccaatc aagagataca gcagttaaat caacgttttt tcggtcagat ttagctgcta
     9361 tttttgtgct tatttttagg gtttttggat tttgtaatga atatttaaaa gttctaaaaa
     9421 ttcacatatt aaagttatcg cttatcgtta atccgataag tcgatgttaa tatctaatca
     9481 cttgttatcg ggacaagcaa ccaaaaaagg caggagacaa atatttaaag tgcacgactt
     9541 gcaaagcagg tctcaaatgt agaaaaggag tagaagactt ggcaggacat gacgttcaat
     9601 acgggaagca tcgtacccgt cgtagttttt caagaatcaa agaagttctt ggtttaccaa
     9661 acttgattga aatccaaacg gattcattca aagaattctt agatactggt cttaaagagg
     9721 tttttgagga tgtacttcct atttcaaact tcacagacac catggaattg gaatttgttg
     9781 gttacgaatt gaaggaacct aagtatacac ttgaagaagc tcgtatccat gatgcatcat
     9841 actcagcacc aatctttgtg actttccgtc ttattaacaa agaaactggt gaaattaaaa
     9901 ctcaggaagt cttcttcgga gatttcccaa ttatgactga gatgggtact tttatcatca
     9961 atggtggtga acgtattatc gtttctcagt tggtgcgctc acctggtgtt tactttaacg
    10021 ataaggtcga taaaaacggt aaagtgggtt acggatcaac agttattcct aaccgtgggg
    10081 catggcttga gcttgaaact gattcaaaag acatcgccta cactcgtatc gaccgtacgc
    10141 gtaagattcc atttacaacg cttgtgcgtg cacttggatt ctcaggtgat gacgaaattg
    10201 ttgatatctt tggtgatagc gagttggttc gtaacactat tgaaaaagat atccacaaaa
    10261 atccagcaga ttcacgtact gatgaagcgc ttaaagaaat ttatgaaaga cttcgtccag
    10321 gtgaaccaaa aactgctgac agctcacgta gcttgcttgt agctcgtttc tttgatccac
    10381 gtcgttacga cttggctgct gttggtcgtt acaaacttaa caaaaaactt aacatcaaga
    10441 cacgtctttt gggacaaaca attgctgaaa acttggtaga tcctgaaaca ggtgaaatcc
    10501 ttgttgaagc tgggactgaa atgacacgtg atgtgattga ttcaatcgca gaacacttgg
    10561 acggtgattt gaacaaattt gtatacacac caaacgatta tgcagtggtt acagaacctg
    10621 ttgttcttca aaaattcaag gtcgttgcac caaatgatcc agatcgtgtg gttacaattg
    10681 ttggtaatgc caatccagat gataaagttc gtgctttgac aacagcggat atcttggctg
    10741 aaatgagcta cttcctcaac cttgctgaag gtatcggtaa agtagatgat atcgaccacc
    10801 ttggtaaccg tcgtatccgt gccgttggtg aattgcttgc taaccaattc cgtattggtt
    10861 tggctcgtat ggaacgaaac gtgcgtgaac gtatgtcagt tcaagataat gaagccttga
    10921 caccacaaca aatcatcaat attcgtcctg taactgcagc tgttaaagaa ttcttcggtt
    10981 cttcacagtt gtcacagttc atggaccagc acaacccatt gtcagagttg tcacacaaac
    11041 gtcgtttgtc agccttggga cctggtggtt tgacacgtga ccgtgccgga tatgaagttc
    11101 gtgacgtgca ttacacgcac tacggtcgta tgtgtccaat tgaaacacct gaaggaccta
    11161 acattggttt gatcaataac ttgtctacat acggacgcct taacaagtac ggtttcattc
    11221 aaacaccata tcgtaaggtt gaccgtgcaa ctggtaaagt aacaaacgaa gtggtttggt
    11281 tgactgccga cgaagaagat gagtacatag ttgctcaggc taactctaaa ttgaacgaag
    11341 atggaacatt tgcagaagaa attgtcatgg gtcgtcacca aggtgttaac caagagtacc
    11401 catcacacct tgtagatttc gtggatgttt ctcctaaaca ggtagttgcc gttgcgacag
    11461 catgtattcc tttcttggaa aacgatgact ctaaccgtgc cctcatgggt gccaacatgc
    11521 aacgtcaagc tgtgccattg attgatccaa aagcaccatt tgttggtact ggtatggaat
    11581 atcaagctgc ccacgattca ggtgctgcag ttatcgctaa acatgatggt aaagttgtct
    11641 attctgatgc cgataaggtt gaagttcgtc gtgaagatgg ttctcttgac gtctatacta
    11701 ttcaaaaatt ccgtcgttca aactcaggta ctgcgtataa ccaacgtact ttggttaagg
    11761 ttggtgatat tgtcgaaaaa ggagatttta tcgctgatgg tccatctatg gaaggtggag
    11821 aaatggccct cggtcaaaac cctattgtcg catacatgac atgggaaggt tacaacttcg
    11881 aggatgctgt tatcatgagt gaacgcctag tgaaagacga tgtttataca tctgttcact
    11941 tggaagaatt cgaatcagaa acacgtgata caaagcttgg acctgaagaa atcacacgtg
    12001 aattgccaaa cgttagtgaa gaagccctta aaaaccttga cgaaatgggt attatccgta
    12061 tcggtgctga ggttaaagaa ggtgatattc ttgttggtaa ggtaacacct aagggtgaaa
    12121 aagacctttc tgctgaagaa cgtcttctcc atgctatctt tggtgataaa tctcgtgaag
    12181 tacgtgatac atcactccgt gtacctcatg gtggtgatgg tgtcgttcgt gatgttaaaa
    12241 tctttacacg tgcaaacggt gatgaattgc aatcaggtgt taacatgctt gttcgtgttt
    12301 acatcgctca aaaacgtaaa atcaaggtcg gagataagat ggctggtcgt cacggtaaca
    12361 aaggggttgt ttctcgtatt gttcctgttg aagacatgcc ttaccttcca gacggtacac
    12421 cagttgacat catgttgaac cctcttgggg taccatcacg tatgaatatt ggtcaggtta
    12481 tggaacttca ccttggtatg gctgctcgta acttgggtat ctacatcgca acaccagtct
    12541 ttgatggggc aagctcagaa gatctctggg atactgttcg tgaagctggt atggatagtg
    12601 atgctaagac aatcctttac gatggacgta caggagagcc atttgataac cgtgtgtcag
    12661 ttggtgtcat gtacatgatc aaacttcacc acatggttga tgataaactt cacgctcgtt
    12721 cggtaggtcc ttactcactc gttacccaac aacctcttgg tggtaaagca caatttggtg
    12781 gacaacgttt cggtgagatg gaggtttggg ctcttgaagc ttacggtgct tcaaacattc
    12841 ttcaagaaat cttgacttac aagtcagatg acgttaacgg acgtttgaaa gcctatgaag
    12901 ctatcactaa aggaaaacca attccaaaac caggtgtacc agaatcattc cgagtgctcg
    12961 ttaaagaatt gcaatcactt ggtcttgata tgcgtgttct tgatgaggat gactatgaag
    13021 ttgaattgcg tgatcttgat gaaggtgaag atgatgacgt catgcacgtt gatgatcttg
    13081 aaaaagcacg tgtacaacaa gccaaagaag ctgctgaatt agaaaaagct aaagaagaag
    13141 ctttagataa aacagaataa aataagcttt agagagggag ttaaatttct ctgctaaggt
    13201 agctgataaa ggtgaaaata gcgctgctat tgtcaataga acaaaagaaa ggtaatacta
    13261 gtggttgacg taaatcgatt taaaagtatg caaattacac tagcttcacc aactaaggtc
    13321 cgttcatggt cttatggtga ggttaagaaa cctgaaacaa tcaactaccg tacgctcaaa
    13381 ccagaacgtg aaggtctgtt cgacgaagtg atctttggtc ctactaaaga ctgggaatgt
    13441 gcgtgtggga aatacaaacg tatccgttat aaagggatcg tttgtgaccg ctgtggtgtt
    13501 gaagtaacac gtgctaaggt tcgtcgcgaa cgtatgggtc acatcgagtt gaaagcacca
    13561 gtatcacata tctggtactt caagggaatc ccttctcgta tgggattgac tttggatatg
    13621 agtcctcgtg cacttgaaga agttatttac ttcgcagctt acgtggttat cgatccaaag
    13681 gaaacaccgc ttgagccaaa atctctcttg actgaacgtg aatatcgtga aaaattgcaa
    13741 gagtatggtc atggttcatt tgtcgctaaa atgggtgcag aagctatcca agatctcttg
    13801 aaacaagtag atttggaagc cgaaattgct gaactcaaag aagagttgaa gacagcaact
    13861 ggtcaaaaac gttttaaagc agttcgtcgt ttggacgttc ttgacgcctt ttacaagtct
    13921 ggtaataaac cagaatggat ggtgcttaac atattgccag tattgccacc agatcttcgt
    13981 ccgatggttc aattggacgg tggacgtttt gcagcatctg acttgaacga cctctaccgt
    14041 cgtgttatca accgtaacaa ccgtttggct cgtttgcttg agttgggtgc tccaggtatc
    14101 atcgtgcaaa acgaaaaacg tatgttgcaa gaagcggtag acgctcttat tgataatgga
    14161 cgtcgtggtc gtccaattac tggaccaggt agtcgtccac ttaaatcttt gagccacatg
    14221 cttaaaggta aacaaggtcg tttccgtcaa aacttgcttg gtaaacgtgt cgacttctct
    14281 ggccgttccg ttattgccgt tggtccaaca cttaaaatgt atcaatgtgg tgtgccccgt
    14341 ttgatggcca tcgaactttt caaaccattt gttatgcgtg aaatcgttgc gcgtgaatac
    14401 gcaggtaacg tgaaagctgc taaacgtatg gttgagcgtg gtgatgaacg tatttgggat
    14461 attcttgaag atgttatcaa ggaacaccca gtgcttctta accgcgcacc taccctccac
    14521 cgtttgggta tccaggcctt tgaacccgtc ttgattgatg gtaaggctct tcgtcttcac
    14581 ccattggtat gtgaggccta caatgccgac tttgacggtg accaaatggc catccacgtt
    14641 ccattgtctg aagaagctca agctgaagca cgtttgctcc ttcttgcggc agaacacatc
    14701 cttaacccta aagacggtaa accagtcgta acaccatctc aggatatggt tcttggtaac
    14761 tattacttga caatggaaga tgaaggccgt gaaggtgaag gtatgatctt caaggatatt
    14821 gatgaggcag ttatggctta tcataatggt tatgttcact tgcatagccg tgtaggtatt
    14881 gcagtcgata gcatgcctga taaaccttgg aaagaaaacc aacttcacaa aatcttagta
    14941 acaactgttg gtaagattct cttcaactca atcattccat cagaaattcc atatcttcaa
    15001 gaaacaacaa atgagaactt gacagatagt acaccagata aatacttcct tgaaccgggc
    15061 caagatatcc aaacagttat cgatagtttg gaaattaatg cgccattcaa gaagaaacat
    15121 cttggtaaca tcattgctga aatcttcaaa cgtcttcgta caactgaaac atcagctttc
    15181 cttgaccgtt tgaaagacct tggttactac tactcaacac ttgctggatt gacagtgggt
    15241 atcgccgata tcccagttat tgataacaaa caagaaatta tcgatgctgc tcaccaccgt
    15301 gttgaagaaa
//
