LOCUS       c00037_JAIQWN0..       14135 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWN010000008.1 Streptococcus thermophilus strain CF3_14
            NODE_8_length_90249_cov_253.292203, whole genome shotgun sequence.
ACCESSION   JAIQWN010000008
VERSION     JAIQWN010000008
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:26:28
            Original ID  :: JAIQWN010000008.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14135
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14135
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1975:4135](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1976..4135
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     cand_cluster    1..14135
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14135
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     CDS             3..635
                     /gene_functions="other (smcogs) SMCOG1130:transposase
                     (Score: 219.1; E-value: 1.2e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg37_1"
                     /transl_table=11
                     /translation="ALGITPEGQKAVLGYEIAPNENNASWSTLLDKLQNQGIQQVSLVV
                     TDGFKGLEEIINQAYPLAKQQRCLIHISRNLASKVKRADRAVILEQFKTIYRAESLEMA
                     VQALESFIAEWKPKYRKVMESLENTDNLLTFYQFPYQIWHSIYSTNLIESLNKEIKRQT
                     KKKVLFPNEEALERYLVTLFEDYNFKQNQRIHKGFGQYADTLESLFD"
     CDS             769..858
                     /locus_tag="ctg37_2"
                     /transl_table=11
                     /translation="MTTQNLNKLPGTIAVPMDKIRITIYCPSF"
     CDS             1019..1891
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_3"
                     /sec_met_domain="TIGR01716 (E-value: 6.1e-31, bitscore:
                     100.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDTIDIGSLTKKIRLSKKLSLKDVAGDYLSVSFLSKFERGESEI
                     SLSRFLCILENLDVSIEEIYGILSKDNPTRTEELLARVSKAFQQNNIPALKKYYYEEIE
                     KFNSTHKKIFLYNSILIDSFLISITGKKMNKKHIEVISDYLFDVDQWGKRELVILGNSM
                     SAVPTNTLNLLIKEIIYKTTLFGNNEENKKIKIDLILNGISIFLERKELNYAKFYIDLF
                     DTLTIPEVYLYERVEYNILIGTYWILIGKIEVGKKKIELALESLKNLGAENLLLMRENE
                     YEELLNSII"
     CDS             1976..4135
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_4"
                     /sec_met_domain="LANC_like (E-value: 5.1e-08, bitscore:
                     24.7, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.7e-14, bitscore: 45.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEELITPSEKRIINRKKGEIYDYISYSNAFVPYQGWKIHISANLI
                     DYQSILDNVYHVCSIFQTPFKYINKISELFRILSKHVSQLEIGKFITIYPKNKETFLLL
                     LEELYDKIPKYTGVQILTDRSYKDSEIIFYRYGVMNARLINNERPKLKFNGTFYEDITE
                     PYYTCPPFVEDIIFNKVVDDYNIESLFHDRYQMESIIHKSGAGNVYIAIDTINEEKVII
                     KEARKKVYITEKILAIDLLLNEKCILKKLKGKVDIPNYIECFTIEGNLYLVEEFIDGQR
                     LDILKPEYNLLIKRNSSELGRYNKKVKKIISNLFLSLYKIHQEGIILEDISSSNILLTN
                     DDRVFFIDLETAYNKNDGIIVETTNECYPKNISQKNEQRDIVKMWYCIIDLLTNSTSLL
                     KYDNTGVSTLNLFYKMSLENNLPKSLRKKFINDFSIVDFKNTFIIKFIEMGLNIEKIVR
                     MQQDLTETILSHNTFEIYGKTILESIDNYKHISNMDLKFSSDPSFSSLYDNCNKSIDDL
                     IGIAILDNNFELFLNCNLDELLHNMSYYQKYYLLRLFNDTKICDRVYFIKVLNSIIKND
                     IKCIDGVKYIKSNEYFSPYLITGNSGLIIELIKFSKNNNTMKFDEWIRSLSEGISYTYA
                     KGTSLYYGLAGLGLANAWLYYYFKETSFLKTSIKICEHIFDFSIKQNTKTILIDPMSEE
                     IDYTYSKGMLGQLYFINELLNIIKE"
     CDS             4140..5708
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 125; E-value: 6e-38)"
                     /gene_kind="transport"
                     /locus_tag="ctg37_5"
                     /transl_table=11
                     /translation="MKKYILKYKLLNLIHIILIGFSSAFLVGASVTLSIMLNKLVESDF
                     KGFLIWLGIEFGVYLLFLADTYLIRVNQTKLIQKMTLSLRDDYINSLTRKSFSEFKNKT
                     VGEHLSILNNDIKIIEESGFESFYSLVSTVFTTFFSIIALFSYDYRIVLLSILLTLILT
                     YLPRSFAHKMEKAMKRFSIGNETFISSLTDQLLGYDTLYYSNKKEMLSIKCGEVIKKFI
                     FEKIVFIKTSSLIEIIMSLFSIISQMLVLLLTGYLIILKQVSIGSISSVGQISGNIFNS
                     LTTFNQLQVSISSVNIIFEKFGAFEKSSHYRYIDKDIEEIKLTNVGYSFKDKEIFKNIN
                     CSFEKGKNYAIVGESGSGKSTLINIILGNNKQYSGSVKYNDVEISDIEESQLFKSVSYI
                     GNITHIYHDSLRNNLTLWDNKINESEIINILKQVNLIDLIPRLDDEVSMSFLSEGQKQR
                     LGIARAYLTKTNVIIMDESMANLDRDNAFLIENQLLNDPTRMYITVSHHLQEKLLDRFH
                     SIITL"
     CDS             6626..7324
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_6"
                     /sec_met_domain="TIGR01716 (E-value: 8.6e-48, bitscore:
                     155.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIEEFVYAVRDFRRDDFNELLEKIRYLVSNRDIDGMKKLLISQM
                     EKKDKKEPFASFNTILIKIRLQDLSGETYVTDQEIVTISDYLFSAEYWGYYELLLFMNT
                     IDALNHNTMMILAKEMCHRLDFYRDIPNNRRLLATMSLNAYITCIERNEWMDALYFEKQ
                     LKYCNFSETEMYEKLVLHYANNLYDLKKNNNRHAVLEMRKCIAATKLVDSNQISIKFEN
                     YLQKVLDDMR"
     CDS             7402..7509
                     /locus_tag="ctg37_7"
                     /transl_table=11
                     /translation="MEKLQVIDLEELLEFDQGYVINASCGPSHSCGGGR"
     CDS             7566..7949
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_8"
                     /sec_met_domain="Fer4_12 (E-value: 2.5e-10, bitscore: 33.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTIETDIGTYYFDSVNFTLSLSPISKQSSPTLDSVEDGVLKKV
                     VINISNSCNLSCSYCYADGGNYGMDNRIMDLTTADNIIQEIASKGVTQINRLILFGGEP
                     FFKYRIIYIFYRKIIYIIKCSEN"
     CDS             7939..8778
                     /locus_tag="ctg37_9"
                     /transl_table=11
                     /translation="VKIETVTNGTVLNKRVKEMLVKFHPYLTISLDGPEIVHDRLRGRG
                     SHRKTLRFINYLKNIDYENFEIASTYTRLHQKNGLSREDIFQYFTDMDVHFNINDVFTK
                     NKVLIVKEMEKSLAERKQFIDKSIQHVINNNEKAFISPILYDVLISMIYKSTNRTFCDD
                     IDPSNTLTYDVDGSKKLCFRFWGTHNSPKAESFNNKDNFEKCKNCWCRGMCLECVANVI
                     DGYSSVISEDGEFLECSKPELMEYCIKQIIYLSKDREKLSRLVNNFRGVYTLCLGVM"
     CDS             8760..10301
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 150.2; E-value:
                     1.4e-45)"
                     /gene_kind="transport"
                     /locus_tag="ctg37_10"
                     /transl_table=11
                     /translation="MLRSYVTKKHLTFYFLAIVITWLEAIITPALIQYIVASFTNRQLH
                     LLWQILLWGIGGNLVLVLGLAGKRYYYARLMTDFKVGIKRAIFRTFLYSRQIPDEEVLS
                     DLENDVQQLENSYIEPTVIIVSSLGFTVVSIAYALWTNFYLGLLFIIFYSVPVLCSGLG
                     SKRLDRIAEQKSLANQNYIARVNNMIAGVAPIRHYQGQNLFFKRFSKDLEQALQEEVSY
                     EKQRSLNSLFINSIDAFCSVAPIVIGGFMTYQNYLSAASFVGIYLVSHNIGYQFQELSY
                     FINTRKSAKSLCDKYQDLFGNKLATDSIFDQSVFPIQLEQVSVEKDGETILAPCDLTIH
                     AGEKIAIIGESGAGKTTLLNILYGEIHPSQGQIRYQGRELTSCQLYQAGAYILQSSHVF
                     DDLSVEENIALGQEIDQQRMDNILQETGLLSLKGKVPSNQTLSGGEKQRLEIARALYHK
                     RQFILADEVKANLDAKNQEKINQLLFSLPQAVVEVIHHYTKEDLKRYDKVIHLKK"
     CDS             complement(10705..11064)
                     /locus_tag="ctg37_11"
                     /transl_table=11
                     /translation="LDKIAEYFNATPTQLFGTSKEIELEKSVLESNEYSDKVSEILKAV
                     KYIENFLETDGQYLEDLLYLTRGKQLYTEDGDELYTDPTSQKRTFHNQYEPGFIVARDK
                     SPLELLIENKELFDK"
     CDS             complement(11095..11217)
                     /locus_tag="ctg37_12"
                     /transl_table=11
                     /translation="MTFIIQNFGPNLARLRIEKGVSQTQLAEDLGIGKQSISDY"
     CDS             11443..12237
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 81; E-value: 2.3e-24)"
                     /gene_kind="other"
                     /locus_tag="ctg37_13"
                     /transl_table=11
                     /translation="VKSGEVLQAAVQTISSQAKAGYSNSQQKGTLIDDFTQHVELFSSK
                     EQQMTEEKYLHTEKDYLDLLLAVKRKFDYQRSIVPYIVYFLLKTGMRFGELVALTWNEV
                     DFDRGLLKTYRRYNTLSHKFVPPKNKTSIRMVPIDEECIKILRLLQTEQERANMELGIK
                     NRYRMIFQHFGYIHSVPDIASVNKALSVLLNELDIYPIITTKGARHTYGSYLWHKGFDL
                     GVIAKILGHRDISMLVEVYGHTLEEKIFEEFNQIRDIWKDCS"
     CDS             complement(12679..13947)
                     /locus_tag="ctg37_14"
                     /transl_table=11
                     /translation="MPDNLALRMRPRSISEVIGQKHLVGEGKIIRRMVEANMLSSMILY
                     GPPGIGKTSIASAIAGTTKFAFRTFNATVDSKKRLQEIAEEAKFSGGLVLLLDEIHRLD
                     KAKQDFLLPLLENGNIIMIGATTENPFFSVTPAIRSRVQIFELEPLSNEDIKEAILNVL
                     GDKERGFAFEVHLDDDALDFIATATNGDLRSAYNSLDLAVMSTPASGNGQHHITLDIVE
                     NSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVNASLHYAARLVEAGDLPSLARRLTVI
                     AYEDIGLANPDAQVHTVTALEAAQKIGFPEARILIANVVIDLALSPKSNSAYKAMDAAL
                     ADLRKSGNLPIPRHLRDGHYAGSKALGNAQDYKYPHAYPEKWVKQQYLPDKLRGVNYFQ
                     PNETGKYERALGANKERIDKLSR"
ORIGIN
        1 tcgcacttgg cattacacca gaaggacaga aggctgttct tggatatgaa atcgctccaa
       61 atgaaaacaa tgcttcttgg tccaccctgt tagacaagct tcaaaaccaa ggaatccaac
      121 aggtttctct tgtagtgacc gatggcttca aggggcttga agagattatc aatcaggctt
      181 acccattagc taaacaacaa cgttgcttaa ttcatattag tcgaaatcta gctagtaaag
      241 tgaaacgagc agatagagcg gttattctgg agcaatttaa aacgatttat cgtgctgaaa
      301 gtttagaaat ggcagtgcaa gctttagaga gctttatcgc cgaatggaaa ccaaagtata
      361 ggaaagtcat ggaaagtctg gagaatacgg ataatctttt aactttttat cagtttccct
      421 accagatttg gcatagcatt tattcgacaa acctcattga gtctcttaac aaagaaatca
      481 aacgtcaaac gaaaaagaag gttctttttc ctaacgagga ggctctggaa cgttatttag
      541 ttaccctgtt tgaagattat aatttcaagc aaaatcaacg catccataaa gggtttggcc
      601 aatatgctga cacacttgaa agcttatttg attaacattc ttcaactcta cttgagtgtt
      661 tacacataat tattgacagt atcgggcaat tcctatatat gaaaatatta atacttaatt
      721 attgcaaaaa tatataatat gtctataaga tttagaaagg agaaaaaaat gactactcaa
      781 aacctaaata agttaccagg aacaattgca gttccaatgg ataaaattcg tattacgatt
      841 tactgtccaa gtttttaagg agaaaaatga ttattcaaat tttgaacagt ttaccaagtg
      901 attcttttga atttaaagat agacttcgta ttacaatata ctcctaatat tcaaaaggtt
      961 aacgcagact gcactatgtt tgcgtttttt gttataattg tataaaagga gttattttat
     1021 gattgatact attgacatag gttctttaac gaaaaaaatt agattatcaa aaaaactttc
     1081 attaaaagat gttgctggtg attatctttc ggtttcgttt ttatctaagt ttgaacgtgg
     1141 cgagtctgag atttcacttt ctcgttttct ttgtatattg gaaaatttgg atgtaagtat
     1201 cgaagaaatt tacggaattt tatcgaaaga taatcctaca agaactgagg aattactagc
     1261 aagggtcagt aaggcatttc aacaaaataa catacctgct ctaaaaaaat attattatga
     1321 agaaatagaa aagtttaatt caacacacaa aaaaatattt ttatataatt ctattttgat
     1381 tgattcattt ttaatatcga taacaggtaa aaaaatgaat aaaaaacata ttgaagttat
     1441 ttctgattat cttttcgatg tagatcaatg ggggaaaaga gagttagtaa tattaggtaa
     1501 tagtatgtca gcggtgccta caaatacatt aaatttatta ataaaagaaa ttatttataa
     1561 gactacttta tttggtaata atgaggaaaa taaaaaaata aaaattgatc ttattttaaa
     1621 cggaatctca atatttttag agaggaaaga actaaattat gccaagttct atattgatct
     1681 ttttgataca cttaccattc ctgaagttta tctctatgag cgagtggaat ataatatatt
     1741 aataggtaca tattggatac ttataggtaa aatagaagtc ggcaagaaga aaattgaact
     1801 agctttggaa tccctcaaaa atttaggtgc tgagaattta ctgctaatga gagaaaatga
     1861 atatgaagaa ttattgaatt ctattatatg acacttttta ctaaaaataa aatactgctg
     1921 ttacactagt tatatagtta tacagcagta ttttattttt aataggagat ttatcatgga
     1981 agaactaatt acaccaagtg aaaagagaat cattaataga aaaaaagggg aaatatatga
     2041 ttatatttca tattcaaatg cttttgttcc ttatcaaggt tggaaaattc atatatctgc
     2101 taatttaata gattatcagt ctattttaga taatgtttac catgtttgtt ctatttttca
     2161 aacgccattt aagtatatca ataaaatatc tgagttattc cgtattttat caaaacacgt
     2221 ttcgcaatta gagattggaa aatttataac tatatatcct aaaaacaaag aaactttttt
     2281 attattattg gaagaactat atgataagat acccaaatat actggagttc aaattttgac
     2341 agatagaagt tataaagact cagaaataat tttttataga tatggagtaa tgaatgcacg
     2401 tttaattaat aatgagcgac caaaacttaa atttaatgga accttttatg aagatataac
     2461 ggaaccatac tatacatgtc ccccatttgt tgaagatatc atatttaata aagttgtaga
     2521 tgactataat attgaatctt tattccatga tagatatcaa atggaatcta ttattcataa
     2581 atcaggagca ggtaatgtat atattgcgat tgatactatt aatgaagaaa aggttattat
     2641 aaaagaagct agaaaaaaag tatatattac agaaaagatt ttagcaatag atctcctttt
     2701 aaatgaaaaa tgtattctaa aaaaattgaa aggtaaagtc gatattccaa attacattga
     2761 gtgctttaca attgagggaa atttatatct tgttgaggaa ttcattgatg gacaaagatt
     2821 ggatatttta aagcctgaat ataatttgtt gataaaacga aattctagcg agttaggaag
     2881 atataataaa aaagtaaaaa aaataatttc taatctattt ttaagtttat ataaaatcca
     2941 tcaggaggga ataatattag aggatatatc ttcaagtaat attcttttaa caaatgatga
     3001 tagagtattt tttattgatc tcgaaaccgc atataataag aatgatggaa ttattgttga
     3061 gacgacaaat gaatgctatc ccaaaaacat ttctcaaaaa aatgaacagc gagatattgt
     3121 taaaatgtgg tattgtataa ttgatttatt aactaattct actagtcttt taaaatatga
     3181 taatacagga gtgagtacct taaatttatt ttataaaatg agtttagaga ataatttacc
     3241 taaatcttta agaaaaaaat ttattaatga ttttagtata gtggacttta agaatacatt
     3301 tataataaaa tttattgaaa tgggtttaaa tatagaaaaa atagttagaa tgcaacaaga
     3361 tttaacagaa actatacttt cccataatac ttttgaaatt tatggaaaaa caatattaga
     3421 gtcaattgat aattataaac atattagtaa tatggattta aaattttcta gcgatcccag
     3481 tttctcttct ctttatgata attgtaataa aagtatagat gacttaatcg gaatcgctat
     3541 acttgataat aattttgaac tttttttaaa ttgtaattta gatgaactac tacataatat
     3601 gagctactat caaaaatatt atctactcag acttttcaat gacactaaaa tatgtgatag
     3661 agtctacttt ataaaggtcc taaattcaat catcaaaaat gatattaagt gtattgatgg
     3721 agtgaaatat ataaaatcca atgagtattt tagcccatat ttaataactg gtaactctgg
     3781 gttaatcatt gaacttatta agttcagtaa aaataacaat acaatgaagt tcgatgaatg
     3841 gattagaagt ttatcagaag gaattagtta tacatatgct aagggaacct cattgtatta
     3901 tggattagca ggattgggtt tggcaaatgc ttggctttat tattatttta aagaaacttc
     3961 atttcttaaa acgagtatta agatttgcga acatattttt gatttttcta ttaaacaaaa
     4021 tacaaaaact atattgatag acccgatgtc cgaagaaatt gattatacat attcaaaagg
     4081 aatgttgggg cagttgtact ttattaatga gttgctaaat ataattaagg aataacataa
     4141 tgaaaaaata tatactaaaa tataaactgc taaatcttat acatataata ttaataggat
     4201 ttagttctgc atttttagtt ggagcatcag tcacactctc aatcatgtta aataaattgg
     4261 ttgaaagtga ttttaaaggc ttcctcatat ggttaggcat tgaatttgga gtttatttgt
     4321 tatttttggc agatacatac ttaattagag taaatcagac taaattaatt caaaaaatga
     4381 ctctttctct cagagatgat tatattaaca gtctaactag aaaatcgttt agtgaattta
     4441 aaaataagac tgttggagaa cacttgtcaa ttttaaataa cgatataaaa attatcgaag
     4501 aaagcggatt tgaaagtttt tattcattag tttcaacagt tttcacaact tttttttcaa
     4561 ttattgctct gtttagttat gattatagaa tagtgctttt atctatacta cttactttga
     4621 tcctaactta ccttccacga agttttgccc ataagatgga aaaagctatg aaaagatttt
     4681 ctataggtaa tgaaacattt atttcatcac taacagatca attactggga tatgatacgc
     4741 tatattattc aaataaaaaa gagatgttat caattaaatg tggagaggta ataaaaaaat
     4801 ttatttttga aaaaatagta tttattaaaa ctagtagctt aattgaaata ataatgagtt
     4861 tattttcaat tatttctcaa atgttagtac tacttttaac aggttatctt atcattttaa
     4921 aacaagtttc aattggttca atatcatcag tcggacaaat ttccggaaat atatttaact
     4981 cattaactac gtttaatcaa ttacaggtat caatatcatc agtaaatatt atatttgaaa
     5041 aatttggagc ttttgagaag agttcccatt atagatatat tgataaagat attgaagaaa
     5101 tcaagttaac taatgtcggg tattccttca aagataagga aattttcaaa aatataaatt
     5161 gtagttttga aaaaggaaaa aattatgcca tagttggaga gtcaggtagt ggaaaatcaa
     5221 ctttaataaa tataatttta ggaaataata agcaatatag tggaagtgta aaatacaatg
     5281 atgtagagat atctgatatt gaagaatctc aattgtttaa aagcgtttca tatataggaa
     5341 atattactca tatttatcat gattctctta gaaataattt aacactttgg gataataaaa
     5401 taaatgaatc agaaattatc aatatcctta aacaagttaa tttaatagat ttaattccac
     5461 gattagatga tgaagtaagt atgtcttttt tatcagaagg gcaaaagcaa agattaggta
     5521 ttgcacgtgc ctatcttact aaaactaacg taataataat ggatgaatct atggcaaatt
     5581 tagatagaga taacgctttt ctaattgaga accagctatt aaacgatcct acaaggatgt
     5641 acattactgt ctctcatcac ttacaggaaa aactactaga tagatttcat agtattatta
     5701 cactttaaat tgagaattca atgttactat acacaacaaa aattaattta tacaaaaata
     5761 atatttatca aaagtttgga aattatttcg gggacaaatg atgggacatt tcctctttag
     5821 acaagtaaga aagcctttat ttaaaggctt ttttatgtat agtatgatgc cccctacatg
     5881 aatttgtatg aatttttcat attgaaaata atcaaaaatg ttgaaatata agttattttt
     5941 agaagatact tggagcattt ttaaatataa ttatttcaaa atggggcaaa agtggggcaa
     6001 aaacgaatga ctcataaagg tttccaactt gctttgaaaa ccaggcttga aaaaggctcg
     6061 taaagcatcg aaatttagta aacgttaaaa ctgatttaca cttattgaaa gcatttcgta
     6121 tccaaaatac gggattcttt ttccataaaa tcaagagagg ttgggcaaaa actacaagtt
     6181 tacccttctg attaaaattt taataaccaa aaatagcttg gaatcaacgt ttataatgac
     6241 gcaattctaa gctatttttt atttttaagg tttcttgcct aatctcttta tcatttggct
     6301 aacctactcc gataacgata ataccttcaa gtattacaaa caacaaacta aacaatgctt
     6361 ttttattcat ggtaaatacc tcttttcgtt ttcttatatg atataatatt tttaatattt
     6421 gtgaagaaat ttcccttata agcaatttag gaggtgacta gaatgaaata tggaaaaatt
     6481 tttaaaaaat ttagagaatc tcgaggttta tctttaaaaa atgttgcaaa atcaggtctt
     6541 tcaagttccc atctctcaag atttgaaaat gatgaggctg atttaaccat cagcaaattt
     6601 ttttttagcg ttagatgcaa tacatatgcc tatcgaagaa tttgtttacg ctgtacgtga
     6661 tttccgcaga gatgacttta atgaactttt agaaaagatt cggtatttag tatcaaatcg
     6721 tgatatagac ggaatgaaaa agctattaat tagccaaatg gaaaagaagg ataaaaagga
     6781 acctttcgct tcatttaaca caattttgat taaaataaga ttacaggatt tatcaggaga
     6841 aacttatgta acagaccaag agattgttac tatcagtgat tacttgtttt ctgcggaata
     6901 ctggggttat tatgaattgc tactgtttat gaatacaata gacgctttaa atcataacac
     6961 aatgatgatt ttagccaaag aaatgtgtca tcgtttggat ttttatagag atattccaaa
     7021 taatagacgt ttattggcaa ctatgtcgct caatgcttat atcacctgta ttgaacgcaa
     7081 tgaatggatg gacgctcttt attttgaaaa acagctaaaa tattgtaact tttcagagac
     7141 tgaaatgtat gaaaaactag tgctccatta tgctaataat ttatatgatc taaagaaaaa
     7201 taataatcga catgctgttt tggaaatgag aaaatgtatt gctgccacga aattggtaga
     7261 tagcaatcaa atatctataa aatttgaaaa ttatttacaa aaagtattag atgacatgag
     7321 gtgaattgcg tataagggaa aatattatcc tcttctgata aggttatata atgaaactat
     7381 caaataaagg aggtgaaaac catggaaaaa cttcaggtga ttgaccttga agaactttta
     7441 gagtttgatc aagggtatgt aattaatgct agctgtggtc caagtcattc ttgtggcggt
     7501 ggtcgatagc ttcttccgag atgaggagtg attcctcatc tcagttttta gtctggagga
     7561 taattatgat aaagacaata gaaacagata taggaacata ttattttgat tctgttaatt
     7621 ttactttatc tttgtcacct atttcaaaac aaagttcacc aactctagat tctgttgaag
     7681 atggtgtatt aaaaaaagta gttataaata tttctaatag ttgtaattta tcttgttcgt
     7741 attgttatgc agatggtggt aactatggta tggataatcg tattatggat ttaactactg
     7801 ctgataatat tatccaagag atagcaagta aaggagttac acaaatcaac cgtctcatac
     7861 ttttcggggg agaacctttt tttaaatata gaattattta tatattttat agaaaaatta
     7921 tctacattat taaatgtagt gaaaattgaa acagttacta atggtactgt tttaaataag
     7981 cgtgttaaag aaatgcttgt taaatttcat ccttatttaa ccataagttt agatggacca
     8041 gaaattgttc atgatagact cagaggaaga gggagccatc gaaaaacatt acgttttatt
     8101 aattatttaa agaatattga ttatgaaaat tttgaaatag cctcgacata tactagactt
     8161 catcaaaaaa atggtctaag tagagaagat atctttcaat attttactga tatggatgtg
     8221 cattttaata taaatgatgt ttttactaaa aataaagtgc taattgtgaa agagatggaa
     8281 aaaagtttgg ctgaaagaaa acagttcata gataaatcca ttcaacatgt aatcaacaac
     8341 aatgagaagg catttatcag tcctatttta tatgatgtat taatatcaat gatatacaag
     8401 agtacgaatc gtacattttg tgatgatatt gacccttcga atacattaac ttatgatgta
     8461 gatggtagta agaaactatg tttcagattt tggggaactc acaacagtcc taaagcggaa
     8521 tcatttaaca acaaagataa ctttgaaaag tgtaaaaact gctggtgtag aggtatgtgc
     8581 ttggaatgcg ttgccaatgt tattgatgga tattcttctg taattagtga agatggggaa
     8641 tttcttgaat gctctaaacc agaactgatg gaatactgta ttaaacagat tatatattta
     8701 tccaaggaca gagaaaaatt atctaggttg gtaaataatt ttaggggggt ttatacgcta
     8761 tgcttaggag ttatgtaacg aaaaaacatc tcaccttcta ttttctagcc atcgtcatca
     8821 cttggttaga ggccattatc acccctgccc ttatccagta tatcgtcgct agttttacca
     8881 accgccagtt gcatctcctc tggcagattt tgctctgggg gattgggggc aatctggtgc
     8941 ttgtcctggg cttggctggg aagcgctatt actatgctcg tttgatgact gactttaagg
     9001 ttgggataaa acgcgctatt tttcggactt ttttatacag ccgtcagatt cctgatgagg
     9061 aggtgctgtc tgatctggaa aatgatgtcc aacagttgga aaatagctat atagagccga
     9121 ccgtcattat cgtatcctcg ctaggtttta cagtcgtttc catcgcatat gccctctgga
     9181 ccaatttcta tctggggtta ttgtttatca tcttttactc tgtaccagtt ttgtgtagcg
     9241 gactgggttc gaagcgtttg gataggattg cggagcaaaa atccctggca aatcagaatt
     9301 atatcgcccg tgtcaacaat atgattgcag gtgttgctcc tattcgtcat tatcagggcc
     9361 agaatttgtt tttcaagaga ttttctaaag acctagaaca ggcgttgcaa gaagaagtgt
     9421 cctacgaaaa gcaacggtca ctgaacagtt tatttatcaa cagtatagat gcattttgct
     9481 ctgtggcgcc cattgtgatt ggcggattca tgacctacca gaactacctt tctgcggcta
     9541 gttttgtcgg catttatctg gtctcccaca acatcggcta ccagtttcaa gaactgtcct
     9601 actttatcaa tacccgcaag tctgccaagt ccctctgcga taagtatcaa gacttgtttg
     9661 gaaataagtt ggctactgac agcatatttg accaatctgt ctttcctatc cagttggagc
     9721 aggtcagtgt ggagaaggat ggggagacca ttctagctcc ttgtgatctg actatccacg
     9781 ctggggaaaa gattgctatc atcggagaaa gcggagcggg caaaaccacc ctgctcaaca
     9841 tcctatacgg ggaaatccat cctagtcagg ggcaaattcg ttatcaagga cgggaactaa
     9901 ccagctgtca actctatcag gctggtgcct atatcttgca atctagtcat gtttttgacg
     9961 atttatctgt ggaggaaaac atcgctctgg gacaggaaat tgaccagcaa agaatggata
    10021 acatcttgca agaaacaggg ctcctcagcc taaaaggcaa ggtacccagc aaccaaactt
    10081 tatcaggcgg tgaaaaacag cgccttgaaa tcgcccgtgc tctctatcac aagcgacagt
    10141 ttatcctagc agatgaggtc aaggctaacc tggacgccaa aaatcaagaa aaaatcaacc
    10201 agctgctctt ttcacttcct caagctgtgg tggaggtcat tcaccactac accaaggaag
    10261 acttgaagcg ctatgataaa gtgattcatt tgaaaaagta gttatgccaa tagtgtctat
    10321 agacaaattg tatatctgaa aggctctttg tcaactgtct tgagttgatg aaaagctaac
    10381 atcgagagag gacacaattc gttctctctt ttcttatctt caaagtgata agaatgcgtt
    10441 ttttaaagtt ttcaaagttc ctaaaatctc atttagaact atttggaatt gtggatacaa
    10501 agcaaccatt gactaaataa ttaatgaatt gaatgagtat ttagagtatt tatttttaac
    10561 tcaaaattga ttaaaatctt gcgtaagccc aaagaactgg gaagaagcga ccgtgacgga
    10621 tatttggaga gaggatttat ctaaaaaact agaaaataag ttatttcttt cataacagaa
    10681 aaagcgagtt caaactcgct ttttctattt atcaaataat tccttatttt caatcaagag
    10741 ttctagtgga gatttgtctc ttgctacaat aaaaccaggt tcatattggt tatgaaatgt
    10801 tcttttctga gaagttggat cagtatacaa ctcgtctcca tcttctgtgt atagttgttt
    10861 gcctcttgtt aggtaaagta aatcctctaa gtactgtcca tcagtttcta gaaaattttc
    10921 gatgtatttg acagccttta agatctcact tactttatca gagtattcat tcgattcaag
    10981 aacactcttt tctaattcaa tctctttact agttccaaat agttgggttg gagttgcatt
    11041 aaaatattct gctatcttat ccaaatttgc aaaggtagga tagctttttt gtttttagta
    11101 gtcagagatg gattgtttac cgattcctaa atcttccgca agttgagttt gacttactcc
    11161 tttttctatg cgtagtcgtg ccaaattggg tccaaaattc tgaataataa aggtcatgat
    11221 aaactcctat gttgtatttt aaacttattc tatcacctat aaacttacaa atcaagtttt
    11281 tagttgactg ctcaaaatat tttttaaatg atacaaatag ctcatatgtt taggaatagt
    11341 gagtgaggag gaatttgagg atgagactat gactatgact gatgactatt cgaagccttg
    11401 gagctagaaa ttgtgtggac aagagcaagg gacgagcctg acgtgaagtc aggcgaagtc
    11461 ctgcaggctg ccgtccagac aatttctagc caagcaaaag ctggctattc taacagccag
    11521 caaaaaggta cactaataga tgattttaca caacatgtcg agttgttttc atccaaagaa
    11581 caacagatga cagaagagaa atatttacat acagaaaagg actatctgga tttactttta
    11641 gcagtaaaga gaaaattcga ttaccaacgt tcaattgttc cttatatcgt ctattttcta
    11701 ttaaaaacag gcatgaggtt tggagagtta gtagcgttaa cttggaatga ggttgatttt
    11761 gacagaggat tgttaaaaac atacaggagg tataatactc tctctcataa gtttgttcca
    11821 ccaaaaaata aaacgtctat tcggatggtt ccaatagacg aagagtgtat caaaattttg
    11881 cgccttttac aaacggagca agaaagagca aacatggagt taggaatcaa aaatcgatat
    11941 cgaatgatct ttcaacattt tggatatatt cattcagttc cagatattgc aagcgtcaat
    12001 aaagctttga gtgttctctt aaatgagttg gacatttatc caattatcac gacaaaagga
    12061 gcacgtcaca cctatggaag ctacctctgg cacaaagggt ttgaccttgg agttattgca
    12121 aaaattctag ggcatagaga tatttcaatg ttggtagaag tatatggaca cactttagaa
    12181 gagaaaattt ttgaggaatt taatcaaatc agagatatct ggaaagattg ctcataaaaa
    12241 aatgtggggc aaacgatggg gcaaatgctc ttaagacaag caaaaaagcc ttggttatca
    12301 aggcttttac tgttgaagtt tgatgccccc tacagggctc gaacctgtga cccatggatt
    12361 aagagtccac tgctctacca actgagctaa ggaggctgga tgctgtattg gtaccgatga
    12421 tccacagttt gtattgaacc cgcgacgtaa aaaagcaggt gggcgactcg ctactaactt
    12481 cagttgcttc tgggtgagcc agcctgcaca ctgttaatag acctctgtct cccgataata
    12541 caaaaattag tcggtcaaca cttatatgtg gattcgtata ccacagcaat ttctatgttt
    12601 ttataatacc acttttgaaa attattgcaa gaggaaaaat catttttttt gcaatcgttt
    12661 tcgttgattc ttctcgtatt atctagataa cttatcgatt cgttctttat tagctccaag
    12721 agctctttcg tatttcccag tttcattagg ttggaaataa ttgactcctc ttaatttatc
    12781 tggaaggtat tgttgcttaa cccacttttc aggataggca tgtggatact tataatcttg
    12841 tgcattaccc agtgccttac ttccagcata gtgtccatct ctcagatgac gcggaatagg
    12901 taaattccca gactttctaa gatccgccag ggcagcatcc attgccttat aagccgaatt
    12961 cgacttaggt gataatgcta agtcaataac tacgttggca atcaaaatac gtgcctccgg
    13021 aaaacctatt ttctgtgcag cttccaaggc tgtgaccgtg tgaacttgtg catctggatt
    13081 agctaaacca atatcctcat aggcaatcac agtcaagcga cgtgctagac taggcaaatc
    13141 ccctgcctca accaaacgtg ccgcatagtg aagactggca ttaacatcag atcctcgaat
    13201 agatttttgc aaggcagaaa ggacatcata gtgcccatca ccgtctttat ccatagtaat
    13261 ataactgcgt tgtaagctat tttccactat gtctagggta atatgatgct gaccatttcc
    13321 tgaagctggt gtcgacatga cagccagatc caaagaatta tatgccgatc gtaaatcacc
    13381 attagtagct gtcgcaataa aatctagagc atcatcatct aagtgaacct caaaggcgaa
    13441 gccacgctcc ttgtccccta gaacattcaa aatagcttcc ttgatatctt cattagagag
    13501 tggttccaac tcaaatattt gtacacggct acggatggct ggtgttacag aaaaaaacgg
    13561 attctcggtt gtggcaccaa tcatgataat atttccgttc tctaataatg gtaacaaaaa
    13621 atcttgtttt gctttatcca aacgatggat ctcatctaga agtagaacta aaccacctga
    13681 aaatttagcc tcttctgcaa tttcctgtag acgttttttg ctatcgacag tggcattaaa
    13741 agttctaaaa gcaaattttg ttgttcctgc aatagcactg gctatcgagg ttttcccgat
    13801 tcctggaggt ccgtagagaa tcattgacga cagcatattc gcctctacca tacggcgaat
    13861 aattttacct tcaccaacta aatgtttctg accaatcacc tctgaaattg aacgtggacg
    13921 catgcgtaag gcaagattat ctggcatctt ctctcctttt tttaactatt tattcttctt
    13981 ataataagaa tatactattt ttctgtaaaa agaaattata aatagttctt gtcaaaccta
    14041 aattcttatg atagaatatt ttggtatgtg gtgctagcac atccgtaata aattctacct
    14101 aggaggaaaa cacgaaatgg ctaaagtatg ttact
//
