LOCUS       c00026_JAIQWS0..       16384 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWS010000033.1 Streptococcus salivarius strain DS85_40A
            NODE_33_length_19128_cov_37.303623, whole genome shotgun sequence.
ACCESSION   JAIQWS010000033
VERSION     JAIQWS010000033
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 20:14:09
            Original ID  :: JAIQWS010000033.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2744
            Orig. end    :: 19128
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16384
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[12744:15528](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12784)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..16384
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16384
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             1599..2573
                     /locus_tag="ctg26_5"
                     /transl_table=11
                     /translation="MEKGKSTNGLMKHIRDKHNIQIKGSKHKTDLLNMGYYHGYKRFRF
                     IKDVSSNQNFTNFDQIKAIHKFDTAVKALIYPLITQVETGLKNRTIDYLVTNSNPDIEA
                     IFRDRLNGYKDYHKINDYKKYRQRLKERLDLRKNIDETIAYYYGKNDSLSHFIHNSRPI
                     PLWGFFEAISFGQYGHFLSALNKDDRLNLCDFIGLTHSGLNADGRLLEQIVFALTGLRN
                     ATMHNAPVYDANFNKETPPKKLKTFLNGKLQITISFDTIIDYIILLLYMMRLQSYSKRE
                     LNIYISNFRKIKDVLYQSVPKSTFDKIVGANSIQKLEKLENIL"
     CDS             4558..4947
                     /locus_tag="ctg26_6"
                     /transl_table=11
                     /translation="VVGKKADNIIQHQYYRQFLEAKRIQPTMSSIGSSPDNAMMEFFFD
                     ILKSEMFYGYDKTSKSLNQLEQAIVDYIDYYNNKRIKVKLKQKRQSQETSTKPHTIASI
                     HRLIRTMYYLITHNKLYDYTSTQNR"
     CDS             complement(5455..6189)
                     /locus_tag="ctg26_7"
                     /transl_table=11
                     /translation="MRHYISAEWKKLNKIQLLIVGVVFVALSSFIGLGTYFANQSVLID
                     GTQDKVMWGQLTFYYSQILYPPMLAIFIAISLIQEFERKNLEMLCSNAISIKKLLISKL
                     FTVTALVIPIQFLVLIVYIVALNVANVELSSFVLLTLKWTLLSILSSFSILCIQAFVYA
                     KTRSFGQSIGISAIGAMGGFVLLFLNENLNKFYPYSQPMIALRSRALDDFSLLELTIFV
                     FVNLLFSVIFYRLTCYELEKRG"
     CDS             complement(6186..6941)
                     /locus_tag="ctg26_8"
                     /transl_table=11
                     /translation="MVNALQIELLKSRRTKSFIITIFLMLIGFLWNTVSTGSEINSVSY
                     DGVSVLFNNQTMNSFFLPIAISIFTSRIVSNELEGQTFKLQESNGTTLTQIFYSKLILS
                     TVFFLILAILETVATNVFAMVNGVSVPLTITILQILGQLLSSFSLICLYLTFAMFTDKQ
                     GLLLSSGFIGGFIGLILASKSTILWTFAIPWVGCSYLSPYKFTLINNSSYLYKFDQSIY
                     FRLLIYLIYCLLLYLLVRSIFLKKERQRK"
     CDS             complement(6943..7851)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 172.5; E-value:
                     1.9e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg26_9"
                     /transl_table=11
                     /translation="MTEVIQLKELKKNFKGVTSVDLERLTVRKGEIYGFLGPNGAGKTT
                     TMKLILSLIVPTSGSIEVMNTPINKSNDYLKYIGSMIEEPSYYPNLTGYENLLVFQKML
                     GFKEENILKTLELVGLSEEKNRKKLVKAYSLGMKQRLALAFALVKEPQILLLDEPTNGL
                     DPSGIHEIRELIIRLAKEEGLTIFISSHILSEIEQIADRVGIINHGRLVYEGEIEKINA
                     NNWVEIEGKFDIEKLKNLFGDSFSNRKVEYTAKLIKIWNANNEQIANIVRSLVELDFPI
                     FRVEHRKENLEDIFLELTKEL"
     CDS             complement(7906..9984)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 125; E-value:
                     6.4e-38)"
                     /gene_kind="transport"
                     /locus_tag="ctg26_10"
                     /sec_met_domain="Peptidase_C39 (E-value: 3e-40, bitscore:
                     127.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILQNNEEDCLLACYTMLLNDLGYKVPLYEVYERDSLPADGLS
                     VSYLLTLNKKFNVDMKAYKANFDEVVSLIRARGNNRMIVHWNNDHFVVLEKITKNYIKI
                     VDPAIGRIKFSKEEFLEHYSGTVITVFPTVDFHRQKVKTLFFKYFKNTLDVRVIFSFLI
                     SLLLIEISILLFSIVIRNMMAGDLKFISSLLLLFTIMLLQVVGYYIKNFALEKYNSNFD
                     KSYTTILFKRLLNKPLLYFRNHTNGSISEKISFRTTLRDSVASKLIPSIISLVSSFVIF
                     IYLAIISFRLTIILVSMIVLYSLISSVLYHKQNEYNQSYLQYLIDFNSDFQSDLEDIDY
                     IKVMRNERGTEDRWIKNNDRLTSKYSQILKVENFVQLFGSIFSYFSLSVIILAVIYNNK
                     FFNVSIADLVLYQTSISLLISSIEQVKTSIFEIARLAIYAEKQGDILKENLPINVNFDL
                     DSNYIIQTENLNFGYGNESLYKPVNLKISQGEKIAIIGKSGSGKSTLLLLLTGMLRYSG
                     KITYNSEHLENYMGVVLQNMTLKKGSVLENFEYDSPDLTKLSKILVDTAADEVIAKLPN
                     KLQSKLLKQGKNLSGGQIQKLLIAKSLLKGEKIIFWDEAFSNLDEVSKDKIYENVLLGD
                     FYKDKTMLIVSHHLDIVNYVGSVIFINDETGEVIKSTHADLQKNNLDYKRFICNKGV"
     CDS             complement(10001..12784)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     717.8; E-value: 3.6e-217)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_11"
                     /sec_met_domain="LANC_like (E-value: 5.2e-63, bitscore:
                     202.8, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 5.6e-74, bitscore:
                     239.5, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHNQLYEQFDKFPLFIIKQKFNYKSLENSNNRKVLEKIILDYYR
                     PTLIYLINEKRVNGELKGNTPEERYDYFNQELCGSGKIFGEIEIRFPEINDRIELIVKK
                     YLDLHERVKSTFVKDFRFLCDNKFLHSDKLKPDLDKLEIEVTGDIHDGAGVCIITYNNQ
                     KVVYKRKSSIANRFLQKIDLMVSEFFNKEIRFIPNILDRDGYFWEQYIDNQKLKNANEA
                     REYYTNMGFLLFYAYIFNISDLHFENILSSGKSPILVDVETLFSTSPFEIIADNFATKE
                     ITQRSRSSVLSSGLLPISEAEKIFGGDLSGILGGTLVNEFKTVINNYRDDIRIEKVVQA
                     TKYQSHLPFFEYLGQKEYLVATNYVNDIIAGFKLVSDFFLNHKEEILEVYQQYSDLKTR
                     ILFRNTHEYDVVSQLLISPIYSQKQDLLFKKMSEKLSHYDSSKLCESEVRQLLSMDIPS
                     FYIAANSTIVTDGYSDVWKIRKTPLYSVTEKLNKLTEDKISEQVELIRFSLQADRDSES
                     TEMQELYKKYDDFRNEENILTNALNNLVDEILAKMYLDPDDESINWMTLKVNDHNNFEL
                     VPMDNSIYDGISGVALSLIECYSLLDENRKRKVYRCLCYLFKTLVNVYSNVLDMTYYVG
                     KLGILSTLVRISQITKQEIPQKILNSKVTLIKQALQNTPADFLTGFSSSILACEDDEYS
                     EEFLRAMIKRFEELKQDDSNNNYIYWGKEESNNVSLAHGNAGIEISLLYLAGKLNSRDA
                     KKMYEDAKKFDDKQKLDQGWVDKRFSDSNAQWCHGSTGVLISRLAQLKLNQEFKILSIQ
                     EESLLVDDIQHAIKQIISIGFDMNNFTLCHGVGGNLLALTYYNNLYGGENSSELEKIIN
                     SEYRKMLSFGIKYGWMCSFNTNFDSYGLMTGLAGIVYSVAKYLKSDSSLEILTPVF"
     CDS             complement(12950..13120)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_12"
                     /sec_met_domain="L_biotic_A (E-value: 5.9e-26, bitscore:
                     80.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 9.3e-08, bitscore:
                     22.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSTNNQSIAEIAAVNSLQEVSMEELDQIIGAGNGVVLTLTHECN
                     LATWTKKLKCC"
     CDS_motif       complement(13025..13120)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKSTNNQSIAEIAAVNSLQEVSMEELDQIIGA"
                     /locus_tag="ctg26_12"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12950..13024)
                     /prepeptide="core"
                     /locus_tag="ctg26_12"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2561.0"
                     /monoisotopic_mass="2559.3"
                     /core_sequence="GNGVVLTLTHECNLATWTKKLKCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKSTNNQSIAEIAAVNSLQEVSMEELDQIIGA"
                     /leader_location="[13024:13120](-)"
                     /alternative_weights="2579.1"
     CDS             13317..14015
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 164.5; E-value: 4.5e-50)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg26_13"
                     /transl_table=11
                     /translation="MDIEAPFLARKILVVDDDVALNHSIREILSVSGFSKIYSAYSISE
                     GIESFVKNSIDLIILDVMLPDGEGYLLSKYVRKKSDIPILFLTAKNEPEDEIQGLQSGG
                     DDFITKPFLPKILIYRTISLLRRSYKEDSSTIKLDHCIINLGNAIVEKDNEKLSLTPIE
                     IQIIRKLYDNKNYIVSTEAICDTVWGIDSFGYEKSLMVHIRNIREKIELNPSKPQYLVT
                     VKGLGYKLMV"
     CDS             14027..15394
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 159.9; E-value: 2.1e-48)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg26_14"
                     /transl_table=11
                     /translation="MFKLRVVTQFIRRFIVSVIVMSIINIFIIVFFVFSQANQTNVMDT
                     VSSLVEQLDISSNSAKLSNLGKKLANSKEVWIMVLDSDSGKEIYEYKKPSEVPTQYSLT
                     DVAKFTRYYLNDYPVFVQIINNKILVFGFSKDNVFRFPFDYYEKSDLHNLFILAFFLLG
                     INCLYLLIIYTYSTRVVQRKITPLVSAIQKLPEGLSGSVETQDELKQLTEAINIADNKL
                     KEGELFKENWISGIAHDIKTPLSVIISNASLIKSDTADKNQLRRLRSILNESYYIQNTI
                     NDLNIFARLTNNQFSLKLESVKIISFFRQIIIQIINQEVWENSDFAFEFDDKLQNSTIS
                     IEKNLISRVLHNIIYNSILHNPEGCNVNIRLHRDKEFLIITIEDNGIGITNDKLLSIHN
                     SNKIIEEFDISGIRRHGMGLKISKQIIEVHEGSFKVESKEKQFFRVIITLPLEGEV"
     CDS             complement(16004..16384)
                     /locus_tag="ctg26_15"
                     /transl_table=11
                     /translation="RYYAQELLRLSERRQVVLNNMVALVQPLPEYDILWSIPGIAETTA
                     TSIIGELEDIRRFQSTNQINAFIGIDLRHYESGNFSPRNTSLNEEIPMSEKSCSSAFTT
                     SLQLVILILAISMTFMRNEKEQ"
ORIGIN
        1 gaggttggac taaaaaggaa tttagtgcca gaatagggaa aacacaacaa actgttggaa
       61 agtgggaaaa tggaagtaat gcccctacat ttaaagatct tgtgaagtta gttggattat
      121 ttggggtgac gtcagactac ttactaggat tatcggactc accaagcaag tacgcttacc
      181 caccaattaa cgacaatagg caagagcaag tagaggaaat gtttaaggaa cttgatgaag
      241 gaaaccaaga cgcgactgtt gatttcatag aaaatcgatt agataatcag cacatctcta
      301 aagaaatcaa agaaaacgac cttaaaaaac aaataggcat taacgaggaa cgaccaacaa
      361 aaagggtcag tatttatgct agagtcgatg cacaaggctt tgaattatca gaagtcccag
      421 ttgactgtct tgactaccct gtgcctattc cagtacatga tatagcactt aagattgtcg
      481 gtaattccat ggaacctatt tttttcgatg atgaagtgat atttgttatg aagaactcta
      541 tcctccgaac aggtgatatc gctattgtac ggttagataa tcggtactgc gtaatgaagg
      601 tatgtaaaaa tagtgaaaat ggtgacatta ttcttaactc gctaaatact gatgagtccg
      661 ctatcactct taccaaggag aatagctgca ctatctttgg taaagttgtc ctaatgtaag
      721 tttggtcttt aaatagtaaa gaagtataag taaaacctta taatccaata atagtgaata
      781 caagataaaa cggcaacccc aatggagttg ccgtttactg cagtacataa cttacagaaa
      841 taaaagaaag taacttcatt atactttctt tctgctaaaa tctcaatagt ttcaaaatat
      901 atcttaactt aactttcagc tatttttctt aaggaatatg attctcaaaa taagaagaaa
      961 cgtaatttga cttaaatcag ttattttgat aaaattttat tcaaaaaaag gaagctgtgt
     1021 agtcactcaa cttccatgta aatccgttta aaaaacgata gctagtttta aacgaaaata
     1081 atccgtctta cttcgccaaa agtggggacg gattattttt ttgtcatcgt ttttaaagag
     1141 tttgtggcat aatccaatta aagcgatggt aaaactaccg atgcctagaa tggtttacac
     1201 aacctcaaac gctgccaaaa ctactttcct ttctaccgga ttttaaatgc ttgcccatag
     1261 caatcacttg tagtattgac ttcctttatt tgagtgtaaa atgggctctt ctttgtttga
     1321 ataagtgctt aaaccatctt aaagtgtttc agatcgtgga gtgaaagttt ttcaagatcg
     1381 gatcgcctat acttaccata tagtataacc catttataga ccgtttcgtg atgattgaac
     1441 acttcctttg gttagataat actctaacca aaacatgtcc atgaaatcat atgctaacaa
     1501 caatgttttt ataggcatct ataaagaact tgataaatga agacagtcta gtataatgaa
     1561 atgtataata agattgtagt cacctatagg gagagaacat ggaaaaggga aaatctacaa
     1621 atggtttaat gaaacatatt cgtgataaac ataatataca aatcaaaggt tcaaagcaca
     1681 aaacagacct tttaaacatg ggatattatc atggttacaa acgatttaga ttcataaagg
     1741 atgtatcatc aaatcaaaat tttacaaatt tcgatcagat aaaagcaatt cataagtttg
     1801 atacagctgt aaaagctcta atttatccat tgattacaca ggttgaaact ggtctaaaaa
     1861 atagaacaat tgattatctc gtaacaaatt ccaaccctga tattgaagct atttttagag
     1921 accgactaaa tggttacaaa gattatcata aaataaatga ttataaaaaa tatcgccaac
     1981 gtttaaaaga aagattagat cttaggaaga atatagatga aactatagct tattactatg
     2041 ggaaaaatga ttctttaagc cattttattc acaatagtcg gcctatccct ttatggggct
     2101 tttttgaagc tatttcattc ggacagtatg gccatttttt aagtgcatta aataaggatg
     2161 atcgactaaa cctttgtgac ttcattggtt taacccactc tgggttaaac gctgacggac
     2221 ggttactaga acaaattgtt tttgccttaa caggactaag aaatgctaca atgcataatg
     2281 cccctgttta cgatgcgaat ttcaataagg aaacaccacc taaaaagctc aaaacttttc
     2341 ttaatggaaa acttcaaatt actattagtt ttgacactat aattgactat attatcttac
     2401 ttttatatat gatgcggtta cagagttata gtaagcgtga attaaatata tatatatcaa
     2461 actttaggaa aattaaggat gtactatatc agtctgtccc taaatcaaca tttgacaaga
     2521 tagtgggagc taactctatt caaaaacttg aaaagttgga gaatatttta taaaatcaaa
     2581 agccttgatt tgcttatatg tttttgttat aattacaata tcgaataggg gtgtagtact
     2641 gcggtctata ctcaaaaggg tggatgcttc caccctttta tttggctctt tttactatat
     2701 cacaagttta tcaagtcttt aagaataaat gagacaagac agtgctattc tgaggttgca
     2761 gcattatttt caaaacttat tgaaccataa aagggtatac gaaaataaca cctcatctgg
     2821 tatgttttaa actaaaatat atcaaatcca tatgataaaa tctatctata aaagtctggc
     2881 tccttccatt gcgaaaaagt tacttttcat cttttaagaa tttattctaa aaatatcagt
     2941 atcacgctag ccacaacctt ctcactaaaa ttgttcacca aataacaatt gccattaccc
     3001 ctcaactcaa gcaaaaacgc aagagtagct cctgcgtttt tctgcattaa tattccacag
     3061 tttacctagc taccttggga gatgatgata catagataaa ctatctagga agtaatatag
     3121 cacaatataa tctaaatcgc aatcgtcata caatctaatt ctattatttt ctagtttata
     3181 aagtaattat ttagccctat aaatgtaatt atcaattcgt tatcaaactc taaaatgtta
     3241 ttagattatt aactatggat atctttgagg tacccttaat tacaatttaa ctagtctcag
     3301 aaaaaatttt ttagcttaat ctgaaatgtt atcttacctt aattgagaat ttgactttca
     3361 gtaaaatttg ttgcgaaatt ctaattgcac tgttataatc tcattagtag gcacatacct
     3421 caaacaatga ataaatcttt ccctcgtctc taattaactt ctattatgga gacttcacac
     3481 taacattctt attttcataa tactcctgta tgaacgtcta ctactaacta gggttccccc
     3541 tagtttttat tttgccctaa ataactttct tgtctataag atgtgttact agccttaaaa
     3601 catctcactt gaaatatggg gagacagttt caattttcgg ttaagacgaa aataccccaa
     3661 atatataagt aattctatta tttgttttta agtgaaataa acttacagaa ataccttcct
     3721 cttcaatgga agaaagaata tctagtctaa gagattatat aatcttgaac tcataattga
     3781 tggaaattct ttgcatatat ttactatttt taatacttta aagataagga ttttaaaaag
     3841 gagaaagatt attatattaa tagatgaaat ctccaagact atctcttagt actaaggtaa
     3901 aggggctata tataagtaaa atcaagtatt tattttcatc gtagattgaa gcaaaataaa
     3961 tgataaagtt ctgcttgaag gtcgttcaca aagaattgta tctttggatt atgctttacc
     4021 agatccttcg ctgttgaaaa aatagatatc tcaatacaag tagattgaat atactattgt
     4081 tgggaaaata agagggagac taattaagaa gggatgtaaa cataagaaga cttggaaagg
     4141 aaagacagaa ccatatcggc ttcaagagaa gaatgaaaga ttacgttcct gggtagacta
     4201 tctaaaagag ctataagaca gtgacaaaac cttaaagcga gaaagacaga gacaattaga
     4261 gaaatgtctt cagcaggatt tcgagtagat ttacttcttg aaacagctcg tttaccgcga
     4321 tcaacttact atcatcattt taagcagcta tgagggctag acaaagataa aaagtttaaa
     4381 gctgaaattc aagctatttt ttctgagcaa aaaagaaatt acggctatca tcgaatgagt
     4441 cttgaatggc gaaatcatgg ttttgtagtg aaccataaaa aggtgcaaca tcttatgaaa
     4501 gcacttagtt taaccaccag gattattcgt aaacgtaagt aatcttcata tcaaggagtg
     4561 gttggcaaga aagcagataa cattattcaa caccagtatt atcgtcagtt tttagaggct
     4621 aaaaggatcc aaccaactat gtcaagtata gggagtagtc cagataacgc catgatggaa
     4681 ttcttctttg acatccttaa gtctgagatg ttttatggtt atgataagac gtctaagtcg
     4741 cttaaccaat tggaacaagc tattgtagac tacattgatt attacaacaa caaacgtatt
     4801 aaggtaaaac taaaacaaaa aagacaatcg caagagactt caaccaaacc acacacaatt
     4861 gcctctatac atcgtctcat tagaacaatg tattacctca taacccataa caaactttac
     4921 gattatactt ctacccaaaa tcgctaaaat tgtttatgcc atattatagt aacgccttat
     4981 caaaaaaatc accagataag gtgttggttt agtgtacact ttttacactg aattatagtt
     5041 aaaaaagaca atttccttag tttgactatg gaactcaaac tatttttcat cagatacctt
     5101 gatatacctg acaaaaggta gaaaaggact tagtcctata cagtacagaa ctaaatcctt
     5161 tgcttaaata aattgtctaa ctttctagag tcagtaaata tcttatcata aattgataca
     5221 acgtaaacaa ttcttgttta tactgatagt aagatagaga attagtaaag cttgtatcgt
     5281 ttggaacatt atgtcataaa ggatgctctt tcagctaaca ctagcgacca tgataatcgt
     5341 atcaatatgt atttagataa acttgcaaca caaatctaac tatagtagca gatcaattca
     5401 gttgttagat aacgacaatt aaccaaatca attaaggcag ttaaataaat tatattatcc
     5461 tcttttttct agttcataac atgttaatct gtaaaaaatc acactaaaca gaagattaac
     5521 aaagacaaaa atagtaagtt ctaataatga aaaatcatct aaagccctac ttctcaatgc
     5581 tatcataggt tgagaatacg gataaaattt attcaagttt tcattcaaaa acaatagaac
     5641 gaacccgccc atggcaccga tagctgaaat accaattgat tgaccaaagc ttctagtttt
     5701 agcatagaca aatgcttgta tgcataaaat agaaaaagag ctcaaaatag ataaaagtgt
     5761 ccattttaaa gttaatagga caaaagaaga gagttcaaca ttagctacgt ttaaagctac
     5821 aatataaaca attagtacga ggaattgaat tggaatgact aatgcagtaa ctgtaaatag
     5881 cttgcttatc agtaattttt tgatggatat tgcatttgaa cataacattt ccaaattttt
     5941 tctttcaaac tcttgaatta aagatattgc tataaaaatt gcgagcattg gaggataaag
     6001 aatctgacta taatagaaag ttaattgtcc ccacatcact ttatcctgtg taccatcaat
     6061 taaaactgat tgattagcaa aataggtacc taagccaata aaacttgata atgctacaaa
     6121 aacaacaccg actattaaaa gctgaatttt attcagcttt ttccattcag ctgaaatata
     6181 atgtctcatt ttctttgtct ctctttcttc aaaaatatac ttcttacaag aagatataac
     6241 agtaaacaat aaattagata tattaaaagt ctaaagtata ttgattggtc aaatttataa
     6301 agatagcttg aattatttat tagagtaaat ttgtaaggag acaaataaga acagccaacc
     6361 cacggtatag cgaatgtcca caatattgta gatttggatg ctaatattaa acctataaag
     6421 ccacctataa aacctgatga taacaataag ccttgtttat cagtaaacat tgcgaaagtt
     6481 aaataaaggc aaatgagact gaaacttgac aatagttgtc ctaaaatttg aagaatagtg
     6541 attgttagag ggacacttac tccgttaacc attgcaaata cattcgttgc aactgtttct
     6601 aaaatagcca atatcaaaaa gaaaacagtt gataaaatta atttactgta aaaaatttga
     6661 gttaatgtag ttccgtttga ttcctgtagc ttaaatgtct gtccttcaag ttcattagaa
     6721 actatacggc tagtgaaaat actaatagct atgggtagaa aaaagctatt cattgtttga
     6781 ttattaaata gcacactaac tccgtcataa cttactgaat taatttcact accagtacta
     6841 actgtattcc acaagaatcc aattaacatg aggaatattg taataataaa cgattttgtc
     6901 ctacgacttt ttaataattc tatttgtaaa gcattaacca ttttataact ccttagttaa
     6961 ttctaaaaat atatcttcga gattttcttt tctatgttct acacgaaaaa ttggaaagtc
     7021 tagttcaacc aaggaacgga ctatattagc gatttgctcg ttattagcat tccagatttt
     7081 aataagtttt gcagtatatt ctacttttct attactaaaa ctatcaccaa aaagattttt
     7141 taatttttca atgtcaaatt ttccttcaat ctctacccaa ttattagcat ttattttttc
     7201 aatttctccc tcgtatacta atctcccatg atttataatt ccaactctat cagcaatctg
     7261 ctcaatttca gatagaatat gactagaaat gaaaattgtt agtccttcct ctttagccaa
     7321 acgaataatc aattcacgta tctcatgaat accagaggga tctaatccat ttgttggttc
     7381 atccaataat agtatctgag gttcttttac taaagcaaat gctagggcta aacgctgttt
     7441 catacccaaa gaatatgctt ttactaattt ttttctgttt ttttcttctg ataaccccac
     7501 aagttcaagt gtttttaaaa tattctcttc tttaaaacct aacatttttt gaaaaaccaa
     7561 tagattttca taacctgtta aattcggata gtaagaaggt tcttcaatca ttgatcctat
     7621 atattttagg taatcgtttg atttgttaat tggagtgttc attacttcaa ttgaaccaga
     7681 agtaggaaca attaatgata ggatcagctt cattgtcgtg gtttttcccg caccattagg
     7741 tccaaggaaa ccataaattt ccccttttct aactgtaagt ctttctaaat caactgatgt
     7801 tactccttta aaatttttct tcaattcttt tagttgtatt acttctgtca ttgtataatc
     7861 catacctttc gttttaaaat ttttgttaat gccaataata aagtattaga cacctttatt
     7921 acaaataaac ctcttgtaat ccaagttatt cttttgtaaa tctgcgtgag ttgatttgat
     7981 gacttctcct gtttcatcat ttataaagat aacactacca acatagttca caatatccaa
     8041 gtggtgactt acaattaaca tagttttatc cttatagaaa tctcccaata aaacattttc
     8101 ataaatcttg tctttgctca cttcgtccaa attactaaaa gcttcatccc aaaaaataat
     8161 tttttcacct ttcaataatg atttggcaat tagtaatttc tggatttgtc ctcccgaaag
     8221 attctttccc tgttttaaca acttcgattg taatttattt ggaagtttag caatgacctc
     8281 atctgctgcg gtatcaacaa gtattttgga tagcttagtt aaatcaggag agtcatattc
     8341 aaagttttct aatacacttc cttttttcaa tgtcatattt tgcaaaacaa ctcccatata
     8401 gttttctaga tgttcactat tatatgtaat cttgccagaa tatcttaaca tgccagttaa
     8461 taataatagc aatgtagatt taccgctacc tgatttacct ataattgcta tcttttcacc
     8521 ttgactaatt tttaaattaa ctggtttata tagcgattca tttccataac cgaagtttaa
     8581 attttcggtc tgaattatat agtttgaatc taaatcaaaa ttaacattta ttggtaaatt
     8641 ttcttttagt atatccccct gcttttcggc atatatagct aatcgtgcta tttcaaaaat
     8701 tgaggttttc acctgttcaa tagatgaaat caataatgat atacttgttt gatataatac
     8761 taaatctgct attgaaacat taaaaaattt attattataa attactgcta aaataataac
     8821 tgataaacta aaatagctaa atatacttcc aaaaagttga acaaaatttt caacttttaa
     8881 aatttgggaa tatttgcttg tcaaacgatc attatttttt atccatctat cttccgttcc
     8941 cctctcattt ctcattactt taatgtaatc tatatcttct agatcagatt gaaaatctga
     9001 gttaaaatca attaggtatt gtaaatagga ttgattatat tcgttctgct tatgatataa
     9061 aacagatgat attaaagaat ataatacaat catagaaacc aaaataatag ttagtctaaa
     9121 agatattatg gccaaatata taaaaattac aaatgatgaa actagactta ttattgaagg
     9181 gattaatttt gatgctacac tatctctcaa tgtcgttctg aaactgattt tttcagaaat
     9241 acttccattg gtatgatttc taaaatataa taatggttta tttagtaatc tcttaaataa
     9301 gatagttgta taagatttat caaaattact attatatttt tctagcgcaa aattcttaat
     9361 ataatatcca acaacttgta gtaacataat agtaaacaat aagagaaggc ttgatataaa
     9421 ttttaaatct ccagccatca tatttcttat cacaatcgaa aatagtaaaa tgctaatttc
     9481 aatcaaaagt agcgaaatca aaaaagagaa aattactctt acatcaagtg tgtttttaaa
     9541 atatttaaaa aatagcgtct tcactttttg acgatgaaaa tcaacagtcg ggaagacggt
     9601 aataaccgtt ccagaatagt gctctaaaaa ttcctcctta ctaaatttaa ttcttcctat
     9661 tgcaggatcc acaattttta tataattttt ggttattttt tctaggacga caaaatgatc
     9721 attattccaa tgaacaatca tcctgttatt gcctctagca cgtattagac ttacaacttc
     9781 gtcaaaatta gctttatacg ccttcatatc tacattaaat tttttattta gagtcagtaa
     9841 ataggaaaca ctcaagccat cagctggaag cgaatctctt tcataaacct cgtacaaagg
     9901 tactttgtat cctaaatcat tcaatagcat tgtgtaacag gctagtaaac agtcctcttc
     9961 attattttgt agaattactt tcattactct tcctcattta tcaaaagacc ggagttaaaa
    10021 tttcaagtga agaatcactt ttcaaatatt ttgccactga gtaaactatt cctgcaagtc
    10081 ctgtcattaa accataagaa tcgaagttag tattaaaact gcacatccaa ccatatttaa
    10141 ttccaaatga aagcattttt ctatactccg aattaatgat tttttctaat tccgagctat
    10201 tttcaccccc atacaaatta ttatagtaag ttaatgctaa aaggtttcca ccgactccgt
    10261 gacataaagt aaaattattc atatcaaatc ctattgagat aatttgcttt attgcgtgct
    10321 gaatatcatc tacaagtaag gattcttctt gtatacttaa aattttaaat tcctgattta
    10381 actttaactg agctaaccta gatattaata ctcctgttga cccatgacac cattgagcat
    10441 ttgaatccga aaacctctta tctacccatc cttggtctaa tttttgctta tcatcaaatt
    10501 ttttagcatc ctcatacatt ttcttagcat ctctactgtt gagttttcct gctaaatata
    10561 ataatgatat ttcaatacct gcatttccat gtgctaagct aacattatta ctttcttctt
    10621 ttccccaata aatgtagtta ttgttactat catcttgttt aagttcttcg aagcgtttta
    10681 tcatagctcg aagaaactct tctgagtatt cgtcatcttc gcaagccagt attgaactcg
    10741 aaaatccagt taaaaaatcc gctggtgtat tttgcaaagc ttgtttaatt aaagtaactt
    10801 tactatttaa tattttttgt ggaatttctt gttttgtaat ttgagatatt cttactaagg
    10861 ttgatagtat ccctaatttc ccaacatagt atgtcatatc taaaacatta gaatacacat
    10921 ttacaagtgt cttaaacaaa taacacaaac atctataaac ttttcttttc ctattttcat
    10981 ctaacaaaga ataacattct attaaactta atgctacccc cgagatacca tcatagattg
    11041 aattatccat tggaaccaat tcaaaattgt tatgatcatt aacttttaaa gtcatccaat
    11101 taatactttc atcatctgga tctaggtaca ttttagcaag tatctcatct acaaggttat
    11161 tcaaagcatt agtcaagata ttctcttcat ttctaaaatc atcatatttt ttatacagtt
    11221 cttgcatttc tgtactctca gaatcacgat cagcttgaag tgaaaatctt attaattcaa
    11281 cttgttcaga tatcttatct tcagttagtt tgttaagttt ctctgtaaca gaatacaagg
    11341 gagttttcct tattttccaa acatccgaat atccatcggt aactattgta gaattagctg
    11401 caatatagaa agatggtata tccatactga gtaattgtct aacttctgat tcacacaatt
    11461 tactactatc atagtgactt agcttctctg acattttttt aaaaagtaaa tcttgttttt
    11521 gggaatatat tggagaaata agcaactgac taactacgtc atattcatga gtatttctaa
    11581 acaatattcg tgtttttaaa tctgaatatt gctgatacac ttccagaatt tcttccttat
    11641 gattaagaaa aaaatcactc actaacttaa aaccagctat tatgtcattt acataattag
    11701 tagctaccaa atattccttc tgaccaagat attcaaagaa tggcagatga gattgatatt
    11761 ttgttgcctg aacaactttt tcaatcctaa tatcatctct gtagttatta atgactgttt
    11821 taaattcatt aactagtgtt ccaccaagga tcccacttaa atctcctcca aatatttttt
    11881 ctgcttcaga aataggaagt aatcctgatg aaagtaccga ggatcggctt ctttgagtaa
    11941 tctccttggt tgcaaagtta tcagctatta tttcaaatgg tgatgtacta aagagagttt
    12001 ctacgtcaac taaaattggc gatttcccag aagaaagaat attttcaaaa tgtaaatctg
    12061 aaatattaaa aatatacgca taaaacaata ggaaacccat attcgtgtag tattccctgg
    12121 cctcattagc attttttaat ttttgattat ctatatattg ttcccaaaaa tatccatctc
    12181 tatctaaaat gtttggaata aaacgaatct ctttgttaaa aaattcactt accattaaat
    12241 ctatcttttg aagaaatcta tttgctatag aactttttct tttatatact accttttgat
    12301 tattataagt gataatacac actcccgctc cgtcatgtat atcacccgta acttcaattt
    12361 caagcttatc caaatcaggt ttcaatttat cagaatgtaa aaatttatta tcacacaaaa
    12421 accgaaagtc ttttacaaaa gtagatttca ctcgctcgtg caagtctaag tattttttta
    12481 ctattaattc gattctatca ttaatttctg gaaatcttat ttcaatttct ccaaaaattt
    12541 taccactacc acatagttct tgattaaaat aatcatagcg ttcctcagga gtgttacctt
    12601 ttagctcgcc attgaccctt ttttcattaa ttaagtaaat caatgttggc ctatagtaat
    12661 ctaatataat tttttctagt acttttctat tatttgaatt ctccaatgat ttgtaattaa
    12721 atttctgttt aattataaat aaaggaaact tatcaaattg ttcatatagt tggttatgct
    12781 tcatacatca aatatccatt ccttgtaaaa atatctatct tatcgcaaaa aataaaagtt
    12841 tgagatatct ttacctcaaa cttttaagtc cattaagtta attaacacaa cttaatatgt
    12901 aacagataaa aatacttgaa tgcttaagta aaattttctt gttaaataat tagcaacatt
    12961 ttagtttttt tgtccaagtt gctaggttac attcatgagt aagagtaaga accactccgt
    13021 ttccagcacc aataatttgg tctagttcct ccatacttac ttcttgtagt gagtttactg
    13081 ctgcaatttc tgcgatactt tgattatttg ttgatttcat agatattctc cttgtttaat
    13141 ttaaatcaat atttagtatc tttatctagc tacaattaca ttttataagt acaagataaa
    13201 gaaatgtcaa aatttacctt aagaaaacct aaagaattta gtgagcttac tttttacttg
    13261 atatttttga tatactataa atatggaaaa ttcaaattat ttcactagga gagctcatgg
    13321 atatagaagc gccttttttg gctaggaaaa tattggttgt tgatgatgat gttgcgttaa
    13381 atcattcaat aagggagata ctgtcagttt ctggtttctc aaaaatatat agtgcataca
    13441 gcatcagtga aggaatagag tcttttgtta aaaattctat tgatttgatt atattagatg
    13501 tcatgcttcc tgacggggaa gggtatttat tatcaaaata tgttagaaaa aaatctgata
    13561 ttccaattct ttttctaaca gcaaaaaatg aacctgaaga tgaaattcaa ggtctacaat
    13621 ctggaggaga tgattttata actaagcctt tcctacctaa aattctcatt tatcgtacga
    13681 tttcgcttct tcggcgatcg tacaaagaag acagtagtac tattaaatta gatcattgta
    13741 ttattaattt agggaatgca attgttgaaa aagataatga aaaattatct ttaaccccaa
    13801 tagaaattca aatcattcga aaattgtatg ataataaaaa ctatattgta tctacagagg
    13861 cgatttgtga tacagtatgg ggtattgata gctttggata tgaaaaatct ttaatggttc
    13921 atattagaaa tatcagagaa aaaatcgaac ttaatccttc aaagccacaa tacttggtta
    13981 ctgttaaagg acttggctac aaactaatgg tgtagggagc ttatacatgt ttaaactacg
    14041 tgtagtaaca caatttatta gacgttttat tgtttcagtc atagtaatgt ccataataaa
    14101 catttttatt atagtttttt ttgtttttag ccaagcaaat caaactaatg tgatggatac
    14161 agtgagtagc ctagtcgaac aacttgatat cagttctaat tctgccaaat tatctaactt
    14221 gggtaaaaaa ttagctaatt ctaaagaggt atggattatg gttttagact ctgatagtgg
    14281 aaaggaaatt tatgaatata aaaagccaag tgaagtccca acacagtata gtctaactga
    14341 cgtcgctaag tttacacgtt attatttaaa tgattaccct gtattcgtac aaattatcaa
    14401 caataagatt cttgtttttg gattttcaaa agataatgtg tttagatttc ctttcgatta
    14461 ttatgagaaa tccgaccttc acaacctctt tattttagct ttttttctac ttggaataaa
    14521 ttgcctgtat ctattaatca tttataccta cagtactaga gtagtccaac gtaaaattac
    14581 ccctttagtt tcagcaattc aaaaactacc ggaaggccta agtggctctg ttgaaactca
    14641 agatgagcta aaacaattaa cggaggctat aaatattgct gacaataaac ttaaagaagg
    14701 ggaacttttt aaagaaaatt ggatttctgg tatagcacat gatataaaga cacctctgtc
    14761 cgttattatt tcaaatgctt ctcttattaa gtctgataca gcagataaaa atcaattaag
    14821 acgtttacga tccattctta atgagagcta ttatattcaa aacactataa atgacttaaa
    14881 tatttttgcc agactaacta ataaccagtt tagtctaaaa ctagaatcag tcaaaataat
    14941 ttctttcttc aggcaaatca ttatacaaat aataaatcaa gaagtctggg aaaattcaga
    15001 ttttgcattt gaatttgatg ataaacttca aaatagtaca atatcaattg agaaaaactt
    15061 aatttcacgc gtacttcata atattatata taactcaatt ctccataatc ccgaaggctg
    15121 caatgtgaat attcgtctac acagagataa agaattttta ataattacaa ttgaggataa
    15181 tggcataggc ataacaaatg ataagctatt atcaattcat aatagtaata aaatcattga
    15241 agaatttgac atctcaggaa ttagacgaca cggtatggga ttaaaaatct caaaacaaat
    15301 tatcgaagtt catgagggaa gctttaaagt ggaaagtaaa gagaaacaat tctttagagt
    15361 tataattact ttacctttag aaggtgaagt ataattattg atagtcattg cagatagagt
    15421 tctattttat atgtggtaaa aattgcactc gtcctggcag attacttaac aaacttgttt
    15481 actcaatagg aactcttcca ttcttcttgc tattccctca tactcattaa gtaatgacct
    15541 agctcctctt gcaatactcc tatttcctca tttacctgtt ctaatgaaat tgattctgtt
    15601 aagattattt tttaaaattc atatcttgct agtttttcat tgctcctttt ggcactcttc
    15661 aaattgataa gtactttcgc tatcttattt aaggttataa ttttttactc ttttctacca
    15721 tttatcaagt ctatcgaggt tttaaataaa aatgagataa gacagtagct attctgaggt
    15781 tactgtctta tttttaacac ttttcgagct ataaaagggc atgcttaaaa aaactcatct
    15841 ggtatttttt gaaacaaggt gtcacaataa taaggtatag atagatttat cgattttagg
    15901 tcaaagaata atcgtaaagt ttgttatgct taataaggta atccattgtc cgaatgagac
    15961 ggtgtataga ggcaatcgta tgtggcttag ttgaagttat tgtctattgt tctttttcgt
    16021 ttctcataaa agtcatcgat atggcaagga ttagtatgac tagctgaagc gatgttgtga
    16081 atgcacttga acaagatttt tctgacatag ggatttcctc gtttagtgat gtgttccttg
    16141 gcgagaagtt cccagattca tagtgtctca ggtcaatacc aataaaagcg ttgatttgat
    16201 tggtagactg aaagcgacga atatcttcca attcgccaat aatagatgtc gctgtggttt
    16261 ctgcgatgcc aggaattgac cataagatgt catactctgg taaaggctga actagagcta
    16321 ccatgttgtt taagacaact tgtctgcgtt cagaaagacg aagcaattct tgagcatagt
    16381 aacg
//
