LOCUS       c00025_JAIQWT0..        6777 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIQWT010000032.1 Streptococcus salivarius strain DS85_40B
            NODE_32_length_6777_cov_27.770753, whole genome shotgun sequence.
ACCESSION   JAIQWT010000032
VERSION     JAIQWT010000032
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 20:16:19
            Original ID  :: JAIQWT010000032.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6777
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6777
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2847:5649](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2848..5649
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..6777
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6777
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             complement(252..1622)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 118.9; E-value: 5.6e-36)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg25_1"
                     /transl_table=11
                     /translation="MIMNQTKILRYSLKKFIFFSIIIFITNIILIASFVFYIREKQTAT
                     KTVKIISEHITITKNNVHIPKNDISSLKEQKLWLMVLDKQTGKQVYEQYKPTEVPSQFD
                     YGDILQFSRYYLSDYPVFSQIKGGYIIVVGFPKDKIARYSYNYLDIDSIRLIPLIAFGV
                     LLFNCLYFAFLYYYGVTHINRKIAPLVTAIQNLPDGLKNPINSISELEYLTTAINQTDT
                     LLKENEVFKEQWISGIAHDIKTPLSVIISNASLLNDSELDTQSEKHIRPILTESYYIQN
                     ILNDLNIVARLSSGHLQLNQTETKIIPFFKDILIHILNQEVWNDFELEFDYDYSLVNQS
                     IMIEQFLITRVIHNIIYNSVLHNEKGCTIRIHLFKKDTNVIVEIKDNGQGASPEKIAEL
                     NELSFKNIDISKIRTTGIGLKISKQIVDLHQGSISFASVQNEFFESIISLPIFNITN"
     CDS             complement(1619..2317)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 175.4; E-value: 2.1e-53)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg25_2"
                     /transl_table=11
                     /translation="MNFEQQLLNKHILIIDDDKILNSSIRDILTAYGFSNLTSAYDIES
                     SLDMIETEQFDLFLLDIMLPDGDGYTLAKHIRKKGDTPILFLTAKNNPEDEVAGFNAGG
                     DDYVMKPFIPKNLIYRIMALLRRSYKSEQEAIQIGQTLVSFRNATVQKNGAEISITPIE
                     IQILKKLYDNKNYIVSTESLCDTIWGVDSFGYENTLTVHIRKIREKIEENPSKPQYLKT
                     AKGLGYKLLS"
     CDS             complement(2502..2639)
                     /locus_tag="ctg25_3"
                     /transl_table=11
                     /translation="MSSCDIRVKWFGLLHHQHQERYQVLQESILEENSLLQSQRDSFVV
                     "
     CDS             2848..5649
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     641.9; E-value: 3e-194)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_4"
                     /sec_met_domain="LANC_like (E-value: 1.2e-53, bitscore:
                     170.5, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 8.4e-82, bitscore:
                     263.6, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENTEKNKLFNKFTRNFIQTNFSEYDMQNCEIEFLEDKVLDIYMN
                     TLILLINEKRLLGILKGSTSEERYEYFNDVLCGKYIIDEIAKRFPKLVSRSLTQLKNYL
                     LLYRKVEQLFLKDVPKLIQNRFISNQCENFKMEDLQITVSGDFHNGSGVCILFYKGERV
                     IYKGKNNFANQLLIEIFSKLGDEFEESLEFLPRYIDCGDYYWEEYIEHTSIRNSNISAS
                     EYYKRFGYLLAVAYLLNISDLHFENILASGDIPKLVDVETIFNLQPYEILSETIADKDL
                     LKRNAESVLLTGLLPLAGSNEVFGGDTSGILGGKFVGEVRVIQNQMRDDISVKRQVVRK
                     TNKSHLPFYISEGEEQYFEVKDYLRELLFGFKKVTSYVENQKNTFLSIIEKYSEKIDVR
                     ILFRNTKDYSIVRTLLLSPKYSENDNIIFEKFKNKLVNYQSDELCESEIKQLEQMDIPY
                     FSMKSNSCDVYDLYGNAVWSTYYSPIELIRKKIQNLSVHIIEEQYKLIEFSISSTLRLY
                     NQEALPRINDVEDKSYSDSILYKGVQNIVDRLLGAIYLSNSDQTCNWLTLSINNVDCLE
                     LSPMDCTLYGGLSGVALALIESMTLLEEDYRKKVRSVLPYLYNSILKKYEYLTNDSFYM
                     GRMGVLYTLKKLSKEVGKDLDNWVNIEIDNVISRLNIGDTDFLTGISSVIPAIRLENLN
                     KVTFEELSDIYIKQAKEKDNFVFWGNEQSNNVSLAHGNLGIELALVRLIKVLDNSNNKE
                     TISTLLKKAINFDNLQRREHGWVDNRNFSHSANWCHGATGVLLSRIDLYNQLKNDKTAT
                     ISSTDLQQDVIHSLQDIKEVGLNLANFSLCHGVSGNLLTLVHTQNFFDENNIVNNYNLK
                     KFVRENFYKIHLYGLQNGWMCNFNTKYDSYALFTGISGILYATTLYLKNDIKSDVLLPN
                     IVS"
     CDS             5662..6777
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_5"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.7e-39, bitscore:
                     121.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIILQNNESDCLLACYAMLLNNLGLEIPLYEIYKEDMIPADGLN
                     VSYLIKLNKRFKVGIKAYRILLKDIAVCLEKNIPVILHWNDNHFVVLLKIRNKKYTIID
                     PAIGKITYSEEEVLKHYSGICVTVFKGVEFKRIKYSNLFVEQLRQTIRLKPAMYFILAL
                     GLTQAGVFLFSITIRNILDVKYSFIASLLMLMSVVVVQLISVLIKNETISEFNNDFDEN
                     YVNKLFKMLLNKPLLYFRNMSNGVLGEKINLKSTIRDSITLKLLPSIVGFISLFVVILY
                     LLTISTKLTFILLILLIFYGIVSSVLYKKQNELNHAYLQYLIDFNSVLQTDLENIDFIK
                     IARKEEQIFKSWKSSNNLVGKMFTDRLIKLRQ"
ORIGIN
        1 tgtagaacct tgtgcagacg gtttttagct cgaacaagat cttcattcat attttcgtgg
       61 agggctatgg aatatatttg ttctttacag agactgaact ttacacggaa gttttggcgc
      121 agaatggatt atttggtttt acgactttct ttatcatctt taaccttgct ttgcttgtct
      181 tggcaggctg ggcagggtat aagatgaaaa aaatggagaa aactctaatg gttcttctcc
      241 atttttttta tctaattggt aatgttgaaa atcggaagtg aaatgatact ttcaaagaat
      301 tcattttgga cacttgcaaa tgaaatagag ccctgatgca aatcaacaat ttgttttgaa
      361 atttttagcc caattccagt cgttctaatt ttagaaatat caatgttttt aaaagataat
      421 tcattaagtt cagcaatttt ttctggtgaa gctccctgtc cattatcttt gatttcgaca
      481 ataacatttg tatctttttt gaacaagtgg attcttattg tgcaaccctt ttcgttatgt
      541 aaaacagagt tgtagatgat attatggata actcttgtga ttaaaaactg ctcaatcatg
      601 atagattgat taacaagtga ataatcgtaa tcaaattcaa gttcaaaatc attccagact
      661 tcttgattta aaatatggat gagaatgtct ttgaagaagg ggataatttt tgtttcagtc
      721 tgatttaatt gaagatgacc ggatgaaagg cgagctacta tatttaagtc atttaaaata
      781 ttttggatgt aataggattc cgtcaatatt gggcgaatat gtttttcaga ctgtgtatct
      841 agttcagaat catttaacaa ggacgcatta gaaatgatga cagaaagagg tgttttgata
      901 tcgtgtgcaa tacctgaaat ccattgctct ttaaagactt cattctcttt gagtagagta
      961 tcggtttgat taattgcagt tgtaagatat tctagttctg atatagaatt tattggattt
     1021 ttcaaaccat ctgggagatt ctgaatagca gttacaagag gcgcaatttt acgattgata
     1081 tgcgtcacac catagtagta aagaaaagcg aaataaaggc agttgaaaag caatactcca
     1141 aatgctatta gtggaatcaa gcgaatacta tctatatcta agtaattata actataacga
     1201 gcaattttat cttttggaaa accaacaaca atgatgtagc caccttttat ctgactaaaa
     1261 acaggataat ctgaaagata atagcgagaa aactgtaaaa tgtctccata gtcaaattgc
     1321 gaaggaactt ctgtaggttt atactgttcg tacacttgtt ttccagtctg cttatccaat
     1381 accatgagcc ataacttttg ttcttttaga ctagaaatat catttttagg tatgtggacg
     1441 ttattttttg tgatggtaat gtgttcagaa attattttca cagtcttagt agcagtttgc
     1501 ttttccctaa tgtagaaaac aaaactggca attagaataa tattggtaat aaagataatg
     1561 atggaaaaaa agataaattt ctttagtgaa taccttaaaa ttttggtttg gttcataatc
     1621 atgataacaa tttatatccc agccctttag ctgtctttaa atattgaggt tttgaaggat
     1681 tttcttctat tttttctcga attttccgaa tatgtacagt taaagtgttt tcataaccaa
     1741 agctatccac tccccaaatc gtatcacaga gagattcggt tgaaacgatg taatttttat
     1801 tatcgtaaag ttttttcaaa atctgaattt caattggcgt aatagaaatt tctgctccat
     1861 ttttttgtac tgttgcattc cgaaaactca ccaaagtctg tccaatctgt attgcttcct
     1921 gttctgattt atagcttctc cggagcagag ccataatacg atagataaga ttttttggaa
     1981 tgaagggttt catgacataa tcatcaccac cagcattgaa accagctacc tcatcttcag
     2041 gattattttt ggcagtcaaa aagaggatag gtgtatcgcc tttttttcgg atatgttttg
     2101 ctaatgtgta gccatcacca tcggggagca taatgtccaa aaggaaaagg tcgaactgct
     2161 ctgtttcaat catgtccaaa ctagattcta tatcataggc tgatgttagg ttggaaaatc
     2221 cgtaggcagt gagaatatct cttatggaag agtttaaaat tttatcgtca tcaatgataa
     2281 ggatgtgctt attcaggagt tgttgttcga aattcataat cttacctcgc ttatcaatat
     2341 tataccattt aaaagagtga aaaaaggcaa aacactttca tcttaatgta aaattaaggt
     2401 tagcttagtt taaaattaat ctagcatgtc tataataaag acataaccta gatagagata
     2461 cttctcaaat aaattttaat cagtgaggta tttccaaatg gctaaacaac aaatgaatct
     2521 cgttgagatt gaagcaatga attctcttca agaattgact cttgaagaac ttgataacgt
     2581 tcttggtgct ggtggtggag taatccaaac catttcacac gaatgtcgca tgaactcatg
     2641 gcagttcttg tttacttgtt gctcttaatt acgttctata agcctaaatt ttagcacgta
     2701 atttgacttt taagaatttt aagggagata tatttaaaat aatatcttct agaaattcta
     2761 atagtatcac aatctaacaa tgagaggtgt ctctactctt ggttttattt atagaaatct
     2821 tgttcatcat gaaaataggt ggtcaaaatg gaaaataccg agaaaaataa attatttaac
     2881 aaatttacta gaaattttat ccaaacaaac ttctcagagt atgatatgca aaactgtgag
     2941 atagaatttt tagaagataa agttttagat atttatatga atacactaat ccttttgata
     3001 aacgaaaaaa gattattagg aattttaaag ggttcaactt cggaagagcg gtatgaatat
     3061 tttaatgatg ttttgtgtgg aaaatatatc attgatgaaa tcgctaaacg ctttcctaaa
     3121 cttgttagta gaagtttaac acaattaaaa aactatctat tactgtatcg aaaagttgaa
     3181 cagctttttt tgaaggatgt tcctaaattg attcaaaaca gatttatttc aaaccaatgt
     3241 gaaaatttta aaatggaaga tttacaaatt actgtatcgg gagattttca taatggttca
     3301 ggcgtgtgta ttttgtttta caagggagag cgagttatct ataaaggaaa aaataatttc
     3361 gctaatcaat tgttgattga aatattttcc aaacttggag atgaatttga agagtcatta
     3421 gagtttttac cacgatatat tgattgtggt gattattatt gggaagaata tatagagcat
     3481 acttcgataa gaaactcgaa catatcagca agtgaatact acaaaagatt tgggtattta
     3541 ttggcagtag cttatttatt gaatatttct gatcttcact ttgaaaatat attagctagt
     3601 ggtgatattc caaaattagt agatgtagag actattttca atttacaacc ctatgagatt
     3661 ctctcagaaa caattgcgga taaagattta ttaaagagaa atgcagaatc agtattgctg
     3721 acagggttgt tacctttagc tggttctaat gaagtattcg gtggagatac tagtggtatc
     3781 ctaggaggaa aatttgtagg agaagttaga gttatccaaa atcaaatgag agatgacatc
     3841 agtgtgaaga ggcaagttgt tagaaaaaca aataagtcgc atcttccttt ttatatctct
     3901 gagggcgaag aacagtattt tgaggtcaaa gactatctta gggaactttt attcggtttt
     3961 aaaaaagtta cgagttatgt tgaaaatcaa aaaaatacat tcttatcaat tatcgaaaaa
     4021 tattccgaaa aaattgatgt tcgtatatta tttaggaata caaaagatta tagtattgtc
     4081 agaacgctat tactctctcc aaagtattca gaaaacgata atataatatt tgagaaattt
     4141 aaaaataaac ttgttaatta tcagtccgat gagttgtgtg aatcggaaat caaacaatta
     4201 gaacaaatgg atataccata cttcagtatg aaatcaaatt cctgtgatgt atatgattta
     4261 tatgggaatg ctgtatggag tacatattac agtccgattg aactaataag aaagaaaata
     4321 caaaatttga gtgttcatat aattgaggag cagtataaac ttattgaatt ttctatttca
     4381 tcaactctta ggctatacaa tcaggaagct ttacctagaa taaatgatgt agaagataaa
     4441 agttattcag atagtatttt atataaaggt gtgcaaaata tagttgatcg tttgttgggt
     4501 gctatttatc tttctaacag tgatcagaca tgtaattggt taactctttc aattaataat
     4561 gtagattgtt tggaattaag tccaatggac tgtacattgt atggcggact ttctggagtg
     4621 gcattggctt taatagaatc aatgactcta ttagaagagg actatcgtaa aaaagtcaga
     4681 agcgttctac catatttgta taattcaatt ctaaaaaaat atgaatattt aactaatgat
     4741 tctttttata tgggtaggat gggtgtgcta tatacactaa aaaaactttc gaaagaggtt
     4801 gggaaagatt tagataattg ggtaaacata gagattgata atgttatttc aaggttaaat
     4861 atcggggata ctgatttttt aactggtata agtagcgtga ttcctgctat taggttagaa
     4921 aatttaaata aggtaacatt tgaagaatta tcggatattt acataaaaca agcaaaagag
     4981 aaagataatt ttgttttttg gggcaatgaa caatcaaata atgtcagcct tgcacatggg
     5041 aatttaggaa ttgaacttgc tttagttaga cttataaagg tgttggacaa ctcaaacaat
     5101 aaagagacta tttcaactct tcttaaaaaa gctataaatt ttgacaatct tcaaaggaga
     5161 gagcatggct gggtggataa tagaaatttt tctcatagcg cgaattggtg tcatggagca
     5221 acaggagtgt tactctctag gatagattta tataatcaac ttaaaaatga caaaacagca
     5281 actataagta gcactgattt gcaacaggat gttattcact ctctacaaga tattaaagaa
     5341 gtgggattga atcttgctaa tttctccctt tgtcacggag taagtgggaa tctactaacc
     5401 ttagtgcata cacagaactt cttcgatgag aataatattg tcaataacta caatttgaaa
     5461 aaatttgtta gagaaaattt ttataaaata catctttatg gtttgcaaaa tggttggatg
     5521 tgtaatttta atacaaagta tgattcttac gcccttttta ctggaatatc aggtatttta
     5581 tatgctacca ctctttacct taaaaatgat ataaaatcag atgtgttact tccgaatatt
     5641 gtatcttaag ggagtttact tatgaagatc atattgcaaa ataatgaatc agattgtttg
     5701 ttggcatgct atgctatgtt attaaataat ctaggtttgg agataccatt gtatgagata
     5761 tacaaggaag atatgatacc agcagatgga ttaaatgttt cctatttgat aaagttgaat
     5821 aaacgtttca aagttggtat caaggcttac agaatactgt tgaaggatat tgctgtttgc
     5881 ttagaaaaaa acattccagt tattttacat tggaatgata atcattttgt tgtcttactg
     5941 aaaataagaa ataaaaaata tacaataatt gatcctgcta taggtaagat tacttactca
     6001 gaggaagaag ttttaaaaca ttattctggt atttgcgtaa cagtttttaa aggagtagaa
     6061 tttaaaagaa ttaaatactc caatctattt gtggaacaat taaggcaaac tattagactg
     6121 aaaccagcaa tgtattttat attagcattg ggacttacac aagccggagt attcttgttt
     6181 tccataacga ttagaaatat tctagatgtg aaatattctt tcattgcttc tttgttaatg
     6241 ctcatgagtg tagtggttgt acaattaatt tctgtcttaa taaaaaacga gactatttca
     6301 gaatttaata atgattttga tgaaaattat gtcaataaat tattcaaaat gttattaaat
     6361 aaacctttac tatattttag aaatatgtcc aatggagtat taggagaaaa aattaattta
     6421 aaatcaacaa taagggatag catcacgtta aaacttctcc cctctattgt aggatttata
     6481 tcgttatttg ttgtgatatt atatctacta actatctcaa ctaaattaac ctttatactt
     6541 ttaatcttat tgatttttta tggtattgtt tcatctgtat tatataaaaa gcaaaacgaa
     6601 ctgaatcatg cttatttaca atatttgatt gattttaatt ctgtgctcca aacagattta
     6661 gagaatatag attttatcaa gattgctaga aaggaagaac aaatctttaa gtcatggaaa
     6721 tctagtaata atttagtggg gaaaatgttt actgaccgat taattaaact ccgacaa
//
