LOCUS       c00012_JAIZBT0..       16537 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIZBT010000002.1 Streptococcus thermophilus strain ST13 2, whole
            genome shotgun sequence.
ACCESSION   JAIZBT010000002
VERSION     JAIZBT010000002
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:38:20
            Original ID  :: JAIZBT010000002.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 104089
            Orig. end    :: 120626
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16537
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[109089:115626]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..11537
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..16537
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16537
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1725..2105)
                     /locus_tag="ctg12_116"
                     /transl_table=11
                     /translation="MSKNLRALTAIVLSQLLIECMGFFLGIPLSKILVLTVLSSIAEVL
                     MHLVLGKKSKVTLSDKEIWHQYFLFVKKTLWLSILFVGIFLFYTLTKSDSFMLYFYWHI
                     FVLFHCLGYIICLNNIKMNRKN"
     CDS             complement(2118..2228)
                     /locus_tag="ctg12_117"
                     /transl_table=11
                     /translation="MAVYDRHAYKNSEAVSAYLCFGNFVGVVKTFCLREV"
     CDS             complement(2230..2400)
                     /locus_tag="ctg12_118"
                     /transl_table=11
                     /translation="MGLAHLAIILTGVYRLLTVRGAEWRLIIIVVIVLDICLLAFLTPR
                     VLKIIKQSERG"
     CDS             complement(2815..3111)
                     /locus_tag="ctg12_119"
                     /transl_table=11
                     /translation="MKGLKWFAGGKERQEQAVAIIDEVIETIGDKPDYADLKQVLHSYR
                     TELADSRSATPYILSRMSLEISKVVRKDQLTLSPCIEERMAELRKLLAIRYGY"
     CDS             complement(3276..4202)
                     /locus_tag="ctg12_120"
                     /transl_table=11
                     /translation="MKKRTLTLWLMSSALLLNLSVGTALADEVVETGADNSPKVEATES
                     TPVEQPSDSQEQSLPEDKEAPAATESVTLAESEEETANDIPAVSREEYDANVADLPKIS
                     LDDVRNAFTEDGQAHTIYFGRGTCYYCRQFSPELKVLNQLMDGRLEYYDIDREDFDRNY
                     VFGEIGIPGTPTLLYLENGQLLSGWVGGGPAQTVYDHLASSSPRFMTLNQEQTTISEPQ
                     TKTVRPTRVTEESTKEKSLPTVQPQPMSTVQKELNAQTGQMAPMTDKVADTKEFPKTND
                     GEQSLVSFVGALAILASLMLALRYYIK"
     CDS             complement(4389..4568)
                     /locus_tag="ctg12_121"
                     /transl_table=11
                     /translation="MFTKLTHNDLEVIQGGAVCLMPNVNNKEGDPLKDGWVSPPRYRSG
                     EAYPMVYLPVCAIM"
     CDS             complement(4597..4989)
                     /locus_tag="ctg12_122"
                     /transl_table=11
                     /translation="MTHRVSKRDIVLFVIAQVVSISLLVLFFSQLLHNLSSVFQLVYIV
                     AALLVVVVDILLIRKIMTRREEPTVLNQLKASLACFLLLTLSCLRFLTTDFYYQKVIAI
                     FVGFFSLLGFVLFLWGIKYINHNIEK"
     CDS             complement(5001..5240)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_123"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.1e-13,
                     bitscore: 42.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGRVNWERWGMCGASVAVGASEGF
                     SAAAGGTAFFIGPYAIGTGAVGAAIGGGVALLGC"
     CDS             complement(5437..5625)
                     /locus_tag="ctg12_124"
                     /transl_table=11
                     /translation="MITELTYNDLETIQGGVSCIMPRTNNKAGGSYDPFIDGRVSPPRY
                     RSGEAYPMVYLPICVLM"
     CDS             complement(5826..6080)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_125"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 6.5e-15,
                     bitscore: 48.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGGCSWRGAGGAAAQGAIGGAIAG
                     AFGGNVVLPVVGSVPGWVGGGALGGVGGTVAYGATCWWS"
     CDS             6336..7067
                     /locus_tag="ctg12_126"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEEAVAHELKSFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIIRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGETIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNKTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGR"
     CDS             7064..8407
                     /locus_tag="ctg12_127"
                     /transl_table=11
                     /translation="MMLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLA
                     FNFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLIT
                     FFIFPFFNISITDYQSSLLISIPSSIAPLCLSFLFIKLFKGSFTILQKQKSNSPIQHII
                     IVANFFMFGYTLLLQILMYLENTTHSSTLELRKLCVVISLVLFFIMIVFLDRNIREMIQ
                     GQLDFQKNLQLENLYTYNKHIEGLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEAYD
                     SVLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGM
                     ETLDFIIVTSIFLDNAIEGAIQTQNPKITISFWEDHCSQLLSISNTISEEKTETKTIFE
                     RGVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     CDS             complement(8425..8586)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_128"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.9e-08,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQA"
     CDS             complement(8601..9968)
                     /locus_tag="ctg12_129"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEWLQK
                     QLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKTNTE
                     VNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQ
                     YATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQF
                     LQNAGQQLSSVETQINDTESKINQADVLLTNTLIQSPEDGILHLSQADKKATMAATGTE
                     LAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSA
                     TETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ"
     CDS             complement(9984..11537)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 293.5; E-value:
                     5.6e-89)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_130"
                     /sec_met_domain="TIGR01193 (E-value: 7.5e-245, bitscore:
                     808.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSTLGIISIGLVVTYVLQQMMTFARDYLLTILSQRLTIDVILSY
                     IRHIFELPMSFFATRRTGEVISRFSDANSIIDALASTILSLFLDFSIVIIVGGVLLIQN
                     SNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSNAMVNSAIIEDINGIETIKSLTSE
                     KVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQLILNVLILWTGAQLVMGNTISIG
                     QLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEFGQSDDTYQEGIAD
                     GDITVTDLSYKYGFGRDTLTDVCLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGH
                     IDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLENLTLGAARGITQADILKACEIAE
                     IRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSSVLILDEATSGLDVLTEKQ
                     VIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGRVVETGSHQDLMSYPGFYYQLFRK
                     "
     CDS             complement(11534..12136)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_131"
                     /sec_met_domain="Peptidase_C39 (E-value: 6.3e-46, bitscore:
                     149.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVLIK"
     CDS             complement(12733..12843)
                     /locus_tag="ctg12_132"
                     /transl_table=11
                     /translation="MTQFTTELLNFGSIISVVGKTTVEIIELFEMVPPQG"
     CDS             complement(13150..14895)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     287.7; E-value: 1.1e-87)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 313.2; E-value: 6e-95)"
                     /gene_kind="transport"
                     /locus_tag="ctg12_133"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGTLSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVAIIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNI
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLI
                     DGVDIRDYSQAELRKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     AMEGE"
ORIGIN
        1 cccttatcaa caagggacta atgaaccttc ctctgataaa ctgacccaca agatggaggg
       61 agacttgctc gtcaaaccag ctggtaagat ttctcttagc cgtccagaaa ttaaagcacc
      121 agaggcagac cttacgccta tcaaccctgt cacaaaggct gaggagcgtt ttgctcacac
      181 tgatacctat acacttaacg attatatgtt ggctcgtggt gtggcttcta tctatgtatc
      241 tggtgtcggt actttcaact cggaaggttt catgacctct ggagactatc aacaagtttt
      301 ggcctataaa gctgtcattg actggctcaa tggtcgtgca cgcgccttta ctagtcgtag
      361 cagacagcat acaatcactg ctgattgggc ttctggtaag gtgactacta ctggactttc
      421 atatttgggt accatgtcca acgcccttgc tacaactggt gttgacggtt tggagatggt
      481 tattgctgaa gcgggtattt cttcttggta cgactattat cgtgaaaatg gactcctcgt
      541 tagccctgga gggtaccctg gtgaggatct cgataccttg actgaattca cctattctcg
      601 tgccctatta gctggagaat acctacgcca ccaaaaagac tacgaggcct acctcaatga
      661 gctaagcaca gctattgatc gtaagcatgg ggattataac cagttctggc atgaccgcaa
      721 ctatgtgcaa ttcgcagacc gtgtcaaagc tactgtagtc tttacacacg gtagccagga
      781 ttggaatgtc aaaccaatta atgtctatca aatgttcaga gcccttccta aatctctcga
      841 aaaacacctc ttcttccata atggtgccca cgtttacatg aatgcctggc agtctattga
      901 cttccgagaa agcatgaacg ccttgatttg tcagaaactc cttgatttag ataatggtta
      961 cacactgcct acagtcatct ggcaaaacaa ccagtctgaa cagacctggg aagttctcga
     1021 taactttggt catgataatg gtaaacacat tcagcttggt aaggcagaag ctagtatcgc
     1081 taaccattac gaagaggaaa tctttgctaa gtacggtaag gcttatcaaa gctttaagga
     1141 tgacctcttt atggataaag ccaatgccat cactctagac tttgaactgg accaagacat
     1201 ccaaatcaat ggtcgtgtcc acctagagct cagggtcaag tctagcacaa accgtggtct
     1261 catttcggcc caagttctgg aaatgggaga taaaaaatac ctagctccaa tacctgaatt
     1321 aaaacgcatg aatgtagata acggccgtct cttcaaggag gaagccttac gtgaattgcc
     1381 attcaagcag gcaaaatacc gtgtcattac caaaggacac cttaacctgc aaaatcgcaa
     1441 agatctcctt agcattgaga atgtcactcc aaatgaatgg atgactatcg gtttggactt
     1501 acaaccaacc atctacaaac tcaacaaggg cgacaaactc cgactcgttc tctataccac
     1561 agactttgag cacactattc gtgacaatag tgactatgaa gtgactgtgg acctaagcca
     1621 aagtaagatg acattgcctt attaatcttt atcgcaaaaa atcccatagg atgagaactc
     1681 ccatgggatt tttttattgt gtgagaataa acaagatttg atcttcaatt tttacgattc
     1741 attttgatgt tatttaaaca aatgatatag ccaagacagt ggaacaacac aaagatatgc
     1801 cagtaaaaat aaagcataaa gctgtcagat ttagtcaacg tataaaaaag aaaaattcca
     1861 acaaacaaaa tggaaagcca gagtgtcttc ttaacgaata aaaagtattg atgccatatc
     1921 tctttatcac tcaaagtgac tttagatttt ttgcctagga caagatgcat cagaacctct
     1981 gctatactgc taagtactgt taaaaccaga atcttactaa gaggaattcc taaaaagaat
     2041 cccatacact caataagcaa ttgggacaaa acaatggccg taagggcacg tagatttttt
     2101 gacataaaac ttaaacctca cacttctctc aaacagaaag ttttcacaac gcctacaaag
     2161 ttaccaaagc atagataagc acttacagcc tcgctatttt tataggcgtg tctatcataa
     2221 actgccattc taacctcgtt cactttgttt aatgatttta agcactctag gtgtcagaaa
     2281 agctagtaaa caaatatcca aaacaatcac aacaataatg attaggcgcc attcggcacc
     2341 tctcaccgtc agcaaacgat aaacaccagt taaaataata gccaaatgtg ccaagcccat
     2401 accagcgtaa atttgtttag gagtaaactg tcgttcccaa gtggacgatt gttcagctct
     2461 cgtccgatga acactggtag gtaggtcaga cacagtaagg aaaccaaacc caggggtaac
     2521 taaaataaga aggaagaacc attatataat aattctaaac caatattgcc atctatcaaa
     2581 ccttaggcaa caaccatgag ttgtaaataa agtaactttc ctgaacgaag tcggttaaga
     2641 taaggcatcg cactcacctt ttatcacaat cacttgtccg cttgtcataa tcataactag
     2701 gacttaaggt tctttctctg ctcctcaaca gattggaaaa gaaccttttt gctccatctt
     2761 ccttttctca atggacaact caaccttaaa accaagaaat cctccctaat gacatcaata
     2821 gccataacga atcgctagca attttcgcaa ctctgccatt cgctcctcga tacagggaga
     2881 caaggttagc tggtcttttc tgaccacttt ggatatttcc agtgacatcc tgcttaagat
     2941 atagggagtg gctgaacgag agtctgcaag ttccgttcgg taggagtgca ggacctgctt
     3001 caaatcagca taatctggct tatctccaat agtttcaatt acctcatcga tgatagctac
     3061 tgcttgttct tgtctctctt tgcctcctgc aaaccattta agtcctttca ttaagaaaac
     3121 ctccttattt ctttcaacta atttttcaat cacatcttta gtatagcaca ctgatagtca
     3181 tttaaaagcc agcgtcacaa aaagtggcta tacgtcctga atggtcattc atatacaaaa
     3241 tgaaaaaaat tgagtgagat actcaatctt ttaacctatt taatataata tctcagtgct
     3301 aacatgagtg aagctaagat tgctaatgcc cccacaaaag agacaagtga ttgctcaccg
     3361 tcatttgttt tagggaattc ttttgtgtct gctactttat cagtcattgg tgccatttgc
     3421 cctgtttgag cgttcagttc cttctgaacc gttgacatcg gctgtggttg aacagttggc
     3481 aaagatttct ctttcgtact ctcttcggtt actcgtgtag gacgaacagt tttagtttga
     3541 ggttcagaga tggttgtttg ttcctgattc aaagtcataa aacgtggact agagctggct
     3601 aaatggtcat aaactgtttg agcaggtcca ccaccaaccc atcctgataa tagctgacca
     3661 ttttccagat aaagtagtgt aggtgtacct ggaataccaa tctcaccaaa cacatagttt
     3721 cggtcaaaat cctcacgatc tatatcgtaa tactctaaac gaccatccat cagttggttc
     3781 aagaccttca actctggtga aaattgacga caatagtaac aggttccacg tccaaaataa
     3841 atcgtatgtg cctgaccatc ctcggtaaag gcattacgca catcatctaa acttatttta
     3901 ggtaaatcag caacattagc gtcgtattcc tcacgagata ctgctgggat atcatttgca
     3961 gtctcctcct cagactcagc caaggttact gattcagtcg ctgctggtgc ctctttatct
     4021 tcaggaagcg actgctcctg actatctgat ggttgttcta ctggagtaga ttcggttgct
     4081 tcaacctttg gagaattatc agctcccgtt tctaccacct catccgctaa agcagttcct
     4141 accgatagat tcagtaacaa ggctgaactc atcagccata gcgttaatgt cctttttttc
     4201 atcataaact cctttcgatt acttagtcta gtttaacaat ttacaactct catagaagct
     4261 aacgtcccaa aaagtgacta tacgtcccga atggtaagaa tataaaaaat cccactatca
     4321 ccagaaggtt cgggtaataa gggggacttt tatattctta tcaaataaga gcctttaaat
     4381 taaagttctt acataatagc acagacaggt aaatatacca tgggataggc ttcaccgctt
     4441 cgatatctag gtggtgatac ccaaccgtct ttaagggggt caccctcctt gttattcaca
     4501 tttggcataa gacaaacagc accaccttga attacttcaa ggtcgttatg agttaatttt
     4561 gtaaacattg cttatactcc ttattttgtc aattacttac ttctctatat tatggttgat
     4621 atacttgatg ccccataaaa atagtacgaa acccaataat gaaaaaaaac ctacaaatat
     4681 agcgataact ttttgataat agaaatctgt tgtcaaaaaa cgaaggcaac taagtgtcag
     4741 taacaagaaa caagctaggg aagcttttaa ttgatttaac acagttggtt cttctcttct
     4801 tgtcattatt tttcgaatga gcaatatatc aaccacaacc actaagagag ctgctacgat
     4861 gtagaccaat tggaatacgg atgataagtt atgaagtaat tgactaaaaa aaagtaccag
     4921 taaggatatg ctaactactt gggcaatgac aaatagcact atatcccttt ttgaaactct
     4981 atgtgtcatt gttgttctcc ttaacagcca agtaaggcta ctccacctcc aatagctgca
     5041 cctactgcac cagttccaat tgcatacggt ccaatgaaga aagccgttcc acctgcagct
     5101 gcagagaatc cttctgaagc acctacggcg acagaggccc cacacattcc ccatcgttcc
     5161 caattgactc gtcctccttc aacactagca agtgtttcaa ggtcgagggt gttaaagttt
     5221 tcaattgttt gagttgccat ggcaactacc tcctaaaatt tttatcgtgt gatctctcaa
     5281 tcacatcttt agtatagcat tcaagtgtct ctatcagagc tagcgtccca aaaagtggct
     5341 atatgtcccg aacggtaaaa aaatataaaa gaccacttta agatgataaa gtgatcttaa
     5401 tagtcattat cgaataagaa ccttgatttc aacttcctac ataagaacac agataggaag
     5461 atataccatc ggataggctt cgccacttcg atatctaggt ggcgataccc taccgtctat
     5521 aaaggggtcg tagctaccac cagctttatt atttgttcta ggcataatac aagatactcc
     5581 accttggatg gtttcaaggt cgttatatgt tagttctgta atcattagtt aactccccat
     5641 ctacataaaa ataaactatt tgttcaaaga aaataacact atcttataaa caaattatta
     5701 aaaattgtta tgaaaatacc cgtatatgtt caagatgatt atttatgttt atttttattg
     5761 accttgttga aaaagatatt acctaacaaa gcaacaacaa aacctataat aaaatatacc
     5821 atagattagc tccaccagca ggttgctcca taggcaacag taccacctac accacctaga
     5881 gcaccaccac cgacccaacc aggaactgag cctacaactg gtaaaactac attacctcca
     5941 aacgctcctg cgatagctcc tccgatagct ccttgagcag ccgctccacc tgcgcctctc
     6001 caactacatc cacctccttc aacactagca agtgtttcga ggtcaagggt gttaaagttt
     6061 tcaattgttt gagttgccat ggcaactacc tcctaaaatt tttatcgtgt gatctctcaa
     6121 tcacatcttt agtatagcat tcaagtgtct ctatcagagc tagcgtccca aaaagtggct
     6181 atatgtcccg aatggtaatt cctaatgtat attatttcta aaattcagaa aaaaaaaaaa
     6241 atctcatttt atactcataa aaaattgaaa aaccgttttc tttatgttac aatttttcaa
     6301 taaacagtat tcatcataaa agagaggact agaccttgaa gatttaccta ttagaagata
     6361 attctattca gatgggtcgc ttggaagagg ctgtggcaca tgaacttaaa tccttcggaa
     6421 aagatctatc ttgtgtccag tcttttgaca aacctgacca gttgttatca gctatcactt
     6481 ctaatacaag cgatcagatt ttctttcttg atattgaaat taaaggtgaa gataagaagg
     6541 gacttgatat cgctaaaatc atacgtcaaa ataaccctta tgctatcatt gcctttgtca
     6601 ctacacatat agagttcatg cctcaagctt ttggcgttac agcctataaa tacatcaata
     6661 aaaccttaga tgaagctagc tttagaaaag aaatagggga aaccattgct caagtcttcc
     6721 ctattaacgc aactaccacg gatgagtttt ttctctacaa aacagagtct caattaataa
     6781 accttcctat ggatcaaatt ctatacctat ccacatcaga tatcaaacac catgttcacc
     6841 tccagactat ccataccctc atggatatcc gagcaaatct ggcagacttt aaaaagatac
     6901 acaaaaagct ctacccatgc catcggtcct atatcgtcaa tacagatatg atcatctctg
     6961 tcaacaagac caattatgaa gctaccttaa ttaatggtca agttctacca gtatcccgta
     7021 tgaagatagg aaagattgca cagattgttg aggaaagagg cagatgatgt taacaacgtt
     7081 atggctactt tttctcaccc ttttaagtgc aggcctagaa attattcttt tcctttattt
     7141 aatgggacag aagattcgtc tgaggtattt tttcctactc cttattttta atttagcctt
     7201 taattttatt tataaccact cttcttggtt tatcattaaa ttctggggtg aggatatcta
     7261 ttatcttctt ctctccttcc ttttatccac taagactaaa aaaccattaa aaataaagat
     7321 tttcaatggt ctcttccctg atatcctcaa caaccttagt ttaagattga ttactttctt
     7381 tatcttccct ttttttaata ttagtatcac cgattatcaa agctctctat taatatccat
     7441 cccttcatct attgcacctc tttgtctatc atttctcttt attaaattat tcaaggggag
     7501 ttttaccata cttcaaaagc agaaatcaaa ttctccgatt caacatatta ttatagttgc
     7561 taactttttt atgtttgggt acaccctact gttacagatc ctcatgtatc ttgaaaacac
     7621 tactcattct tcaactttgg agcttcgaaa actctgtgtt gttatttcac ttgtcctctt
     7681 cttcattatg attgtctttt tagacagaaa cattcgtgaa atgattcaag gacaattgga
     7741 cttccaaaaa aatctccagc tagaaaatct ctacacctac aataaacata ttgaaggtct
     7801 ctacaattct gttcgtagtt ttagacacga ttatagtaat ctcttagtca cattacgatt
     7861 ggggatagat aaagacgata tggatattgt caaagaagcc tatgatagtg tgcttcaaga
     7921 atccgataaa cgattaaata caagaaactt tgacttagct agactcgtta atattcagga
     7981 taacactttg aaaagccttc tgtccgcaaa agttctacaa gcagaagaag aaggcattga
     8041 agctcagatt agcatcccag aacccatcca cttgattggg atggagactc tggacttcat
     8101 tatcgtcact tctatttttt tagataacgc tattgaaggt gccattcaaa ctcaaaaccc
     8161 taaaattact attagctttt gggaagatca ttgttcacag ctattatcta ttagcaatac
     8221 cataagtgaa gaaaaaacag aaaccaaaac catatttgaa agaggtgtct ccaacaaggg
     8281 acgagagcga ggcattggcc ttgctaatgt cacagaaatc ttagataact atatcaatgt
     8341 aaacttagaa acacagagta acaatttctc attcacacaa caattaacaa taactaaaaa
     8401 ggcctaacag ccttttttct atacctaagc ttgaggaatg ttatagtctt ttgttggaag
     8461 cgttctttgc cctccgaatc cttttaggaa accatttata taatccatcc acccacttcc
     8521 acctacgact tgttcaagag cgtggttatc aagtgtttca aagttattaa tcgtattgtt
     8581 agccatcagt aattctcctc ctattggtct tgcaagttta gtaacttgtc tttaaagtaa
     8641 ttgaagtagg tcttttggtc aataacgctt gtcacacgac cttctagacc gtaacgtaga
     8701 ttttgggctt ctttttctga aatacttgcc ctagcagtta ctctaaacac attccccctt
     8761 tctgtttccg tggcagaatt atcaatactc tcaagttttc caataattgt ggtaccgtga
     8821 ttaccaacct tatccaaggt cagtcgaact gactggcctt tttgcagttt tggcacataa
     8881 tccgaattca cataataagt aatggcaact tcctgggttt gagtcatatc gggataaagc
     8941 tgggccaact cagttcctgt cgcagccatg gttgcttttt tatcagcttg actcaagtgt
     9001 aagattccat cttctggtga ctggatgagg gtattagtca gaaggacatc tgcctgattg
     9061 attttactct cggtatcgtt aatttgtgtt tccactgagc tcaattgctg tcctgcattt
     9121 tgcaagaatt gattttttag agcttctttt ttagtgctat cactattgtc ataagttaca
     9181 actgtgcctg tcccagcctt ttggatttct agattaccta tggaagcatt caagctcgaa
     9241 atattggtat taacttgaga taggtattgg tctgttacac tggcatccgg tgttgtagca
     9301 tactgactgt tataggcatt taaggttgcc tgatgaggat tgccttcagg taaagtcgtt
     9361 tcatgattgg taatagcttg agagagcgcc tcatactctg agacctgagt ctgcaattga
     9421 ctaatctggt tatcaatagc agaaccggta ttactcgcaa ttgctgcttg gttattaacc
     9481 tctgtatttg ttttagccac acccaagtca atatcctgtg cctgacttag gtaggtgtta
     9541 aaagtactct gataaccaaa ctcgtcttcc tgttcttgga aaagattggt tccctgcgtt
     9601 aggctagatt gcaaggtctt caaacctgat tcctgtcttt ttaaaagttc tagttgcttt
     9661 tgaagccact ctttttgcga tgcctccatg gtctctgaat actgaactaa ggtgtcccct
     9721 tttttaacaa ccttattagc aaccagttga ttatctatga tggtattgtc actggttgat
     9781 tggattactg cgataacctt ggttggctct atacttcctc tagacgtgac tgtaacttcc
     9841 ttcttagcaa aaaaagcgaa aagaaaaagg aaaataacta acaaaatcaa gggagtaatc
     9901 aaaacagtag acatattgtg gtagcgacga tggtaaaact ctgtgctttt aaacaactgt
     9961 ggattcatcg tgtttccttt tcctcacttt ctaaataatt gataatagaa acctggataa
    10021 gacattaggt cttgatgaga acctgtctcc actacgcgtc cgtgatcaat gactacgata
    10081 cggtcggtcc gctcagcgat actaagcctg tgtgctacaa agatgatcgt tttatctttt
    10141 agtgctagga ggttatcaat aacctgcttt tctgtcaaaa catccaatcc gctagttgct
    10201 tcatctaaga ttagtacaga agatttcgtt agtagtgcac gcgccaaagc gatacgttgc
    10261 ttttgccctc cagacagacc tgctccatca gacagctctg tctgaaaccc cataggcatg
    10321 ttttcaatat cttgacgaat ttctgctatt tcacaagctt tcaaaatatc agcttgcgta
    10381 ataccccgtg ctgcacctaa agtaagattt tctaaaacac taccactaaa tatataggat
    10441 tgctgaggga gatagttaat atgttgacga agagttttct tgtctatgcg actaatattt
    10501 tgaccattaa aatctatgtg ccccttatat ggttgataaa aattgaccaa cattttagct
    10561 agagtagtct taccagatcc actgacacca acaaaactga ttttttctcc ttgtctaatc
    10621 gtcaaacaga catcagtcaa agtatcacga ccaaaaccat atttataaga taaatccgta
    10681 acagtgatat ctccatccgc aatgccttct tgataggtat catcactttg tccaaactct
    10741 gattcaatca gatagacctc attgagccta gtattagcta ccttagcaga ctgtaacttg
    10801 gtttgcaggt taatgatatt ttccaaagga ttcgtgaagt aagaaagcaa catattaaaa
    10861 gtaatcaatt gtcctatcga aatggtattt cccatcacca actgagcacc tgtccagagg
    10921 ataagtacat ttaaaataag ttgagcacct tgtttcaatg atgtttgtag tatagataac
    10981 ttagaaaggc gaaaagaatt gtctagatag tcaataaact caccatcaat cttttgatag
    11041 catacttttt cgctggttag tgactttatg gtttcaatcc cattaatgtc ctcaatgatg
    11101 gctgaattaa ccatagcatt actctgcatg acgtcatgat tcattcgctc aaaaggtttc
    11161 ataaaggcaa agacgataag ggtataaatt ggaaccgaac aaagaactag cttgaagaga
    11221 ttgctatttt gtatcaataa cacgcctcct acgataatca caatagagaa atcaaggaaa
    11281 agtgataata tcgtcgaagc cagagcatcg ataatagagt tagcatcact aaaacgtgag
    11341 ataacctccc ctgtacgtct tgtggcaaaa aaagacattg ggagttcaaa gatatgtcgt
    11401 atgtaggaca agataacgtc aatggtcaat cgctgactca gtatggttaa gagataatct
    11461 cttgcaaaag tcatcatttg ttgtaaaaca taggtcacaa ctaatccaat tgagataatt
    11521 cctaaggtag acttcatttg attaggacat attcgtctag aataccttgt aaataatagg
    11581 aacctaaaat atttattaaa gtaaccaaga gactggcaaa gacaatatta gctatcaagg
    11641 acctttgttt aaagatcaaa gggagaaagt cccagagtcc atttttctta tccttatgtg
    11701 gtttataact gggttccggt cccataaaaa gagtaacacc tgtccactct ttctcaaaac
    11761 gctctttagt cattttagtt acttttacac ttggatcagg gtctccaatt atcagataat
    11821 ccttggtgct tttataaata acataataat gttgaagctt cccatcttta ttaacatgag
    11881 caataaaagg ataaggaaca tcttccatct caaagagcga catttcagcc tttatagctc
    11941 tcgtttcaaa gccaattttt ttagcagcct ctacaagacc taaggcagtt gtcccttctt
    12001 tattggtctt cgccaactca cgcagatgtg ctaatgaata atctgaacca tagtacttgg
    12061 ccactgatgc caaggcagca actccacaat ccctcatatc tatttgaggg acaaaagtcc
    12121 tacgaaaacg aaacatacca aaccctttca tcacaaatta tcatatgatt agtatgtcat
    12181 attttcagga taaaaagagc cagcgtccca aaaagttgcc atacgtccca aacggtaaga
    12241 aaaatcttaa agtcatctcc actattacca tttaagccgt atttggggtc atttaggaca
    12301 agttcattga aatcgatttc aaagttatac aatagttatt agaaggaaac attctaaaat
    12361 agtcctacaa gcatacgtat ttgatctaac cattattact gtgccagccc tggtatttcc
    12421 aaaggaaacc atgactgctg atagcctcgg agcctatctc tatcgtatga tgtcataatt
    12481 tgattatttt tattccgaaa agggataaca ttatgaaaaa cgtcaatcca tatctcaaaa
    12541 aatcctatca aaaaaggcta aatcagcctc ttgagattcg attactcaat tatcggttta
    12601 attttcctta gctttgtaag tgtatttgtt atcactgtca atgctatttt tagcgtcact
    12661 agaggggttc ccttccttaa tgcccacctt atttccacct tgagtaattg tgccttctat
    12721 cttttgattt actcaacctt gaggtggcac catctcaaaa agctctataa tctctacagt
    12781 ggtttttccc actacagaaa ttatagagcc gaagttaagt agttctgtgg taaactgagt
    12841 cataggaata aatctctttc tagtaatgtt ttgcaactct actataacgg atttattcct
    12901 ttttgtgttt acacaactta ttttacacta cctcaacgtt tgcaagtacc tcgagatcga
    12961 gtgtttcaaa tgtattattt gtttgccttg tcattctaac aacctcctaa attattttta
    13021 gctttttctc tcaagctatg attttattat agggtggtag ccaacaaaaa agtagtgaca
    13081 taaatgtcac tactcgattt tgatttttaa gaaatctttt cgaatataga agctatggtc
    13141 tagattagct tactctcctt ccatggcgcc tgcttgtagg ctgtacatct tgtgataggt
    13201 gccgccgagg gctaggagct cttcgtggct accatgttca atgatgcggc ccttgtctaa
    13261 gacatagatg cagttagcat cttggattgt tgataggcgg tgggcaatgg caatggttgt
    13321 acggccttga cgcatttttg caagagagtt ttgaacaata gcctctgtct ccgaatcaat
    13381 attggctgtc gcttcatcca aaatcaagat tttaggctgg ctagcaacgg ttctagcaaa
    13441 ggctagaagc tggcgttgac cggttgagaa acttgaacca cgttcggaaa ctggggaatc
    13501 atagccttca ggaagtttat caataaagtg attggcatcg acaaactcag cagcagcttt
    13561 aatctcttca tcagttaaat cttgatacat ggcaatattg gatttgattg tgccatgata
    13621 gaggaagggg tcctgaagga caagaccaat attcttgcgc agctctgcct gactataatc
    13681 acgaatatcc acaccgtcta tgagaactcg tcctgattgg aattcataga atcgcatgag
    13741 cacgttgata atagaggatt ttccagagcc tgtagatccc acaaaggcga tggtttcacc
    13801 tttattgaca gagaaggaaa tattatccaa aatctggtgc ttgccatcat aggagaagga
    13861 gacattctca aagcgaatat tcccctcagt aaccttggca gctgtgtctc tctgttcagg
    13921 ctcataggta cgctcgtcaa tcaaggcaaa gacccgacct gctgagacca tagaggtttg
    13981 tagagtcgag aagttttgtg tcacttcaat caagggatca aagaggcgat taatatactg
    14041 gataaaggca tacatggtac ctgctgtgat acccagatag atacctcggt agccaaaata
    14101 ggccatgaga acagcataag ccaggagctt cagtagactc atggctgggc gtagaaagag
    14161 agaatccagt gatatagaac ggctggcata aatcaggtgt tcctcattaa tggcatcaaa
    14221 ctctttttta agacgcttct cctggttaaa ggcctgaatg atgtgaatcc cttcgatact
    14281 ctctgacagt ttggcattta tatctgaaag caaggctctg gtcttttcaa tgatggccac
    14341 tgattttttg cgataaaggt taaccaaaag gacaatcaga ggaagaaaga ggacaataag
    14401 cccggtcaga cgaatgtcca agatcatcat ggtgtaaagg gtggtaacaa agataaagat
    14461 agccgaaata aaactagaca gagttcctga gaacatctcg ctaatggtct cagtatcatt
    14521 ggtcaagcgg gaaacgatgg aacctgctgg ggtcttgtca aagtaagaca tacccagttt
    14581 ttccatattg gcaaaggcat ctcgacgaat atctctgaca atgctatagg acacacgcgc
    14641 aaagaagaga tttcccagat actggactag tgtctgcaag aggtagagac catagtagcc
    14701 aatcagaatc atacttgccg cctgattcat atcatgaaga tagtgatcaa taaaataaga
    14761 ggccaccaag ggaatgatac tcttgataac cgttgtggac aagaggaagg tcaaagctag
    14821 aaaggtcaag aacttgtaag gcttgagata ggtcaagaga cgcttaaaca cagaccattg
    14881 gttttgatta ggcatgagct tctcctcctt ccatttctaa ctgttgagac tcataggtct
    14941 tggcatacca accaccttga gctagtaagt cgtcatgacg cccacgttca atgatacgac
    15001 catcttgcat gaccaggatg aggtcagcgt gcaccaccgc actgagacgg tgggcggtaa
    15061 taatagttgt tttgtccttg cgagtatgct taagattatc aataatggca tgttctgtct
    15121 tagcatcaac cgcagataag gagtcatcca aaatcaaaat ttctggattc aaaatcatgg
    15181 cccggctcat agccagacgt tgtttttgac cacctgatag gctgacaccc ttttcaccaa
    15241 tgattgtttc aaagccttca ggcatatcct tgatatcatc ataaacttga gctaacttag
    15301 tcgcttcttc caccttatca atggagaaat ctggattacc aaagcggata ttgtctaaaa
    15361 tagaactggc aaagagaaac tggtcttgag gaacataacc aatcaagcta cgcaagtctg
    15421 ataggcgata gtctcggatg tcatgtccat tcaaatagat ggctccttga ttgacatcgt
    15481 gctcccgcaa gagcaacttg acaagagccg tctttcctga gccagtcggt ccaaccaaac
    15541 caagggtttg ccccttgtcc aaggtgaaat gaatatctcg caaagtatcc tcatcctcaa
    15601 aagcaaagcg gtcaatcgca aagtctaaac gaccattttc aatgcttgga agaggataag
    15661 cgggatcttg aacatctgat tcctgctcta aaagagtctc gatacgttgg taggacacat
    15721 ttcccctctg cgtgatatta aagaggaagc caatggccat taggggccaa accagcatgt
    15781 ccaaataggt aataaaggtt accaaatttc cgaccgttat ctgaccggcc tgaatcataa
    15841 aggccccgac aaggagggtc aaaacataag atgagccaac aaagagcaag accaaaggat
    15901 caaaaaggct gtcatacttc atggtatgca tattcttttc aaaagtcatc ttattggtct
    15961 cttggaagga ctggagctca gcctcctgat agccaaaaga cttggttacc ttgatacctg
    16021 acaccgattc ttgtacctta ttattaagtt cagaaaaagc tgcctgggat tctccaaaag
    16081 ctttgtgggt cttacgtccc aaacgactag tcgcaaaagc catgaaaggt agaggtaaga
    16141 ctgccatcag ggtcatctgc caggaaatgc tgaagaacat ggtgattaaa gtcaccaagg
    16201 ctgtgataga cgcatccacg gctgacatga cacccccacc agccaaacgg gttagagagt
    16261 tgatatcatt ggtggcatgg gccatgagat caccagttcg gtacttttgg taaaaagaag
    16321 gcgacatctt ggtaaaatgc tcaaaaagcc gcgaacgcat aatctgtccc aagcgataag
    16381 acgttgccaa gatatacatc cgccaaacat agcgcaaata gtacattcct aaagccgcca
    16441 aaagcaaata aacgagattc aaaagcaaga tctgattggt caattttccc gatgtgatag
    16501 catcaatgac ccgacccata accataggag gaatcag
//
