LOCUS       c00009_JAIZBV0..       12812 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIZBV010000017.1 Streptococcus thermophilus strain ST10 17, whole
            genome shotgun sequence.
ACCESSION   JAIZBV010000017
VERSION     JAIZBV010000017
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:42:41
            Original ID  :: JAIZBV010000017.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12812
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12812
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:2812]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3..2812
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..12812
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12812
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             complement(3..803)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_1"
                     /sec_met_domain="PF04055 (E-value: 3.1e-22, bitscore: 71.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-10, bitscore: 33.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 8.9e-17, bitscore:
                     53.4, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSNVYSIFFNWYNKQGILRNNRNNKLFSLNLATFLALKFMYQFS
                     LKKFSDSKSQVIKNVIDFLNNNEISLSKTNTKIVEFSTKIPLKVIQIEVTNKCNLRCMH
                     CYLPDYSKELDRKKISSIVYEAKQLGVMDVDFTGGEPLLLQGLSEIIEEVLKEGMCTTI
                     FTNAVYIPEDFKILIQRYDGIRLKVSLDGWNETIHDSIRGRGTFKRTIKNIEYFRSLGV
                     PVTVNVVLNNKNISGVKYFLELFDRLDVKYAFDRFLPFERNNRLS"
     CDS             complement(886..1035)
                     /locus_tag="ctg9_2"
                     /transl_table=11
                     /translation="MQVSDAIAQIELAEEEVVSSGLSIDIMEIKPSVATELIDGLKGRC
                     PPSV"
     CDS             complement(1095..1895)
                     /locus_tag="ctg9_3"
                     /transl_table=11
                     /translation="MRIIKFPEQISEDIIHYTFLDDIISYNCEKCRGSCCHVNNSLLLD
                     AKTASFLKRTYLKDFIVSDDSVSLLSCGKKCWFHSELGCTINDLGLNKPLTCELYPFHI
                     KKIQNFYIVSFTPCPTFQLNLGEGQRYKDIEDVVLRYIKTGVPVFSPSLHVSEERLKYE
                     IEYQNNFKNTLSEYYRTKTADGTTEFKEYEKWYIYYLDFRWGSIPLSYTSSQANQFWNL
                     YKRVCEDVYKKISYIRTDNIYFIIANQFNKTISKHFQLNFIDKE"
     CDS             complement(1955..2812)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_4"
                     /sec_met_domain="TIGR01716 (E-value: 1.3e-46, bitscore:
                     150.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYGKLFKKFRESRGLVLKDIAKLGVSVSHISRFERENTDLTIS
                     KFMSALNAINMPIDEFMYAANDFQRDEFNEILEKISLFVSARNVSGMEKLLISQVEKIE
                     KRETFYTLNTILIKIRLQDLSDKSYYDESDIQYLSDYLFSVEYWGCYELLLFANTVDVL
                     NHQTMMLLSREMCKRSEFYKDLPNYRRLHSTMLLNCYIISIERDEYIDALYFEKQLNHS
                     CFTETEIYEKLVFHYSKNLYELKKNRSNKAILEMKKCIAAMKLANSENLAIKFENHLSG
                     VLKM"
     CDS             complement(3335..5167)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 550.4; E-value:
                     9.1e-167)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_5"
                     /transl_table=11
                     /translation="MPNIEELKQRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMDLERERGITIKLNAIELNYKAKDGETYIFHLIDTPGHVDFTYEVSRSLAA
                     CEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRTEIEDVIGL
                     DASEAVLASAKAGIGIEEILEQIVEKVPAPQGDVEAPLQALIFDSVYDAYRGVILQVRV
                     VNGMVKTGDKIQMMSNGKTFDVTEVGIFTPKAVGRDYLATGDVGYVAASIKTVADTRVG
                     DTVTLADNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPET
                     SQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSE
                     FPDPTRIDAIEEPYVKAQIMVPQEYVGAVMELAQRKRGDFETMEYIDDNRVNVIYQIPL
                     AEIVFDFFDKLKSSTRGYASFDYELSEYRRSQLVKMDILLNGDKVDALSFIVHREFAYE
                     RGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARTDIKALRKNVLAKCYGGDVSRKRKLL
                     EKQKAGKKRMKAIGSVEVPQEAFLSVLSMDEDEK"
     CDS             complement(5381..5536)
                     /locus_tag="ctg9_6"
                     /transl_table=11
                     /translation="MALFFCLIKHNVSDNIVINNYVFKGGFPYQTSYTILLSTHFLVLF
                     YWELLY"
     CDS             complement(5555..5701)
                     /locus_tag="ctg9_7"
                     /transl_table=11
                     /translation="MQTFAKDITLKRLSEPEDVAAAVSFLAGPDSNYITGQTIIVDGGM
                     QFH"
     CDS             complement(5977..6318)
                     /NRPS_PKS="Domain: PKS_KR (3-112). E-value: 3.7e-11. Score:
                     35.0. Matches aSDomain: nrpspksdomains_ctg9_8_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     111.9; E-value: 5.8e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MSKVAIVTGAGQGIGFAISKRLVEDGFKVGVLDYDAETAEKAVVE
                     LSEDKAFSVVADVSKQAEVAAAFQKVVDHFGDLNVVVNNAGVHQQNPLETITEEQFQRT
                     FNINVGGVI"
     aSDomain        complement(5983..6309)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg9_8_PKS_KR.1"
                     /evalue="3.70E-11"
                     /label="ctg9_8_PKS_KR.1"
                     /locus_tag="ctg9_8"
                     /protein_end="112"
                     /protein_start="3"
                     /score="35.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAIVTGAGQGIGFAISKRLVEDGFKVGVLDYDAETAEKAVVELSE
                     DKAFSVVADVSKQAEVAAAFQKVVDHFGDLNVVVNNAGVHQQNPLETITEEQFQRTFNI
                     NVGGV"
     aSModule        5983..6309
                     /domains="nrpspksdomains_ctg9_8_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg9_8"
                     /tool="antismash"
                     /type="pks"
     CDS             complement(6529..6822)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163:rhodanese domain-containing protein (Score: 59.2;
                     E-value: 5.6e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="MDIAQIQSELAQDGLLIDVRTPEEYAEGHVKDALLIPHTQFFTAD
                     IPAKKDDSIYLYCKMGSRAEFAAGVLKERGYTKVTTLGGLGDMEALGFKFEK"
     CDS             complement(6824..7252)
                     /locus_tag="ctg9_10"
                     /transl_table=11
                     /translation="MKVGNMQKTFFIIKPDAVKRHLIGQVLDRIERRGFVIERMEMLML
                     DEERLKEHYAQLADKPFFPSISEFMMSGPAVIGIMSGPGVIKSWRDMMGATNPGDAAPG
                     TIRGDFATAPDGDMIPNIVHGSDSEESAAREIKIWFGE"
     CDS             7405..7560
                     /locus_tag="ctg9_11"
                     /transl_table=11
                     /translation="MTKSKFQLVGSLLRPADLRKYKDEIEHRDDIQYPFYDALPGYQET
                     ETASIK"
     CDS             7557..8354
                     /locus_tag="ctg9_12"
                     /transl_table=11
                     /translation="VNVADQKANGIDILTDGEFGRSMWHLDFVWGLKGIERYIAEHGYT
                     FKDHDGGQYETRKDIGIRVTEPLSGKNHHYLDIYKLVKAEAGDEDTKQTIWGPAHTYTE
                     LAIFDQLAVPGQVYETNEELKKGLINVYKEFLDEYKAVGGKIVQFDDCLWELFDPSNPA
                     SFYSDGNGDLAELADEFVAINNEVVDYTHELGLTVWTHNCRGNYEIRSASEGTYEDIAK
                     KFLAEQHYDRFFLEWDSDTAGDIKALEALKDSKAEVVFGLLSS"
     CDS             complement(8619..9962)
                     /locus_tag="ctg9_13"
                     /transl_table=11
                     /translation="MSQSKADYINVIGAGLAGSEAAYQIAKRGIPVKLYEMRGVKATPQ
                     HKTTNFAELVCSNSFRGDSLTNAVGLLKEEMRRLDSIIMRNGEAHRVPAGGAMAVDREG
                     YAEAVTAEIESHPLIEVIRKEITEIPDDAITVIASGPLTSDALAEKIHELNGGDGFYFY
                     DAAAPIVDKATIDMNKVYLKSRYDKGEAAYLNCPMTKEEFMAFYEALTTAEEAPLNSFE
                     KEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPEDYMGPRDGDFKTPYAVVQLRQDN
                     AAGSLYNIVGFQTHLKWGEQKRVFQMIPGLENAEFVRYGVMHRNSYMDSPNLLKQTFQS
                     KSNPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKGEDEVIFPHTTAIGSLPYYVTH
                     AESKHFQPMNVNFGIIKELEGPRIRDKKERYEKIAERALKDLQTFIDA"
     CDS             complement(10063..11457)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 126.7; E-value: 2.4e-38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg9_14"
                     /transl_table=11
                     /translation="VALIKKREHSLRTILLSYVVSLTVLSVISSLLILYLFSLSFRFGV
                     LIPANQVESDLSAVRSDIETSKVFNPEILPDGTSYVFLTRDFKLKKSNMPVNLQEESLL
                     NYQFKNAHGEKYGYFQSFERSDGIVIVNYQLSPRYRNEWMNQHFPNADLMMIGSMFVSI
                     LIIFIILTFYYANKLSQQLKPILRVTEKISQQDLDFQTSQSTIKEFNQVLSGLDHMRIA
                     LRESLMENWKAEQDKQNQISALTHDLKTPLTVARGNAELLAMTSLDENQTDLLEHFQKG
                     IAQVDAYVKELSELNKMSLKKTLTLEEVPVKEFVEDIYDQTLSLAQTKQINVVFDKKEI
                     AKESIGNWDKSLLNRAIMNIVSNAVEHTPSGSQLLLTARVEEDEFKFICLDSGPGFSLE
                     SLENATQLFYQEDKSRHSRNHSGLGLTIANDIIRLHYGSLSLANDNGTGGAKVTIILPL
                     LNTDDS"
     CDS             complement(11448..12107)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 180.3; E-value: 6.9e-55)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg9_15"
                     /transl_table=11
                     /translation="MARILVIDDQKDIVQLVVKALELQNHNVTGLTSVLDLDKNSLPRF
                     DLILLDIMMPDVDGLQFCHEIRNQVDCPILFITAKTQEADIVQGLSYGADDYICKPFGV
                     KELQARVAAHLRREHRERHHKLSLGEFQFDLSAQELYIENQLLDLTKSEYGICQFLAEN
                     KGQVFSKEQIYTHLYGYEDKGSPAAVAEHIKNIRAKLKEVGQNPIETVWGIGYKWH"
ORIGIN
        1 attgatagtc gattattcct ttcaaaaggt aaaaacctat caaaagcata tttcacatct
       61 aatcgatcaa acaactccaa aaaatacttc actccactaa tattcttgtt attcaaaaca
      121 acattaacag taacaggtac tcctaaactc ctaaaatatt caatattctt aattgttctc
      181 ttaaatgtac ctcttcctct aattgaatca tgtattgttt cattccaacc atctaaacta
      241 acttttagtc ttataccatc atatctttga atcaatattt taaaatcttc aggaatatat
      301 acagcatttg taaaaattgt tgtacacatt ccctctttta atacttcctc gataatttca
      361 cttaatccct gtaataataa tggttcgcct ccagtgaaat caacatccat tactcctagc
      421 tgcttagctt catatactat acttgaaatt ttctttctat cgagctcctt tgaataatca
      481 ggtaaataac aatgcataca tcttaggtta catttgttcg tgacctcaat ctgtatcact
      541 tttaatggta ttttcgttga aaattcaaca attttagtgt tggtcttaga gagtgatatt
      601 tcattgttat ttagaaaatc tataacattt tttattacct gactctttga atcagaaaac
      661 tttttcaatg aaaattggta cataaatttt aaagctaaaa atgtagctaa atttaatgaa
      721 aatagtttat tattcctatt attcctgagt attccttgct tattgtacca attaaaaaaa
      781 atcgagtaaa cattgctcgt catattaatt ccctgcaatc ttccaaaaat attaatataa
      841 aaaccaaagg attagagata gactctaatc ctacaatcag ttctattaga cagacggtgg
      901 gcaacgacct ttgagtccat caatcaactc tgtagcaaca gaaggtttaa tttccataat
      961 gtcaatagat agaccgctag aaacaacttc ttcttctgct aattcaattt gtgcaatagc
     1021 atcactaact tgcatcgtaa tatcctccat tatttattta agaatcaata agtacccata
     1081 acaaatcata gaaatcattc tttatctata aaatttagct gaaaatgctt tgaaattgtc
     1141 ttattaaact gatttgcaat aataaagtat atgttatctg ttcgtatata tgatattttt
     1201 ttataaacat cttcacaaac tctcttgtaa agattccaaa attgatttgc ttgtgaactt
     1261 gtataagata agggtatact tccccatcta aaatctaaat aatatatata ccatttttca
     1321 tattctttaa actctgtagt gccatcggca gtctttgttc gataatactc tgataaagtg
     1381 tttttaaaat tgttttgata ctcaatctca tatttcagcc tttcctctga aacatgcaaa
     1441 gacggactaa aaactggcac cccagtttta atatatcgta aaactacatc ctctatatcc
     1501 ttgtacctct gcccctcacc aaggttcagt tgaaatgtcg gacaaggagt aaaagaaaca
     1561 atatagaagt tctgaatttt cttaatatga aaaggatata attcacaagt taatggcttg
     1621 ttcaagccta aatcatttat cgtacaaccc aattcagaat gaaaccagca ctttttacca
     1681 caactcaaca atgaaacact atcatcacta acaataaaat ctttaagata cgtgcgtttt
     1741 agaaaacttg ctgtctttgc atcaagtaat aaagaattat tcacatgaca acaagatcct
     1801 ctacactttt cacaattata agagataata tcatctagaa acgtataatg aatgatatct
     1861 tctgaaatct gttcaggaaa tttaataatt ctcatatcaa taatatatca tttaattttg
     1921 acactgataa tttataccat atacacaaat ccaactacat ttttaacact ccagataaat
     1981 gattttcaaa ttttatagct aaattctcac tattagccag cttcattgca gcaatacact
     2041 tcttcatttc tagaatagct ttattgctcc tattcttctt taattcatat aaattttttg
     2101 aataatgaaa cactaatttc tcgtaaatct cagtttccgt aaaacaacta tgatttaact
     2161 gtttttcaaa atacaacgca tcaatatact catctctttc aatacttatg atataacaat
     2221 ttaatagcat tgttgagtgt aaccttcggt agtttggtaa atccttgtaa aattctgaac
     2281 gtttacacat ttctcttgat aaaagcatca ttgtttgatg attcaataca tctacagtat
     2341 tcgcaaataa cagtagttcg taacaacccc aatattctac agagaatagg tagtctgata
     2401 aatattggat atcagattca tcatagtaac ttttgtctga taagtcctgt aaacgaattt
     2461 ttattaaaat agtatttaga gtataaaaag tctcacgctt ttcgattttt tctacttgag
     2521 agattaataa cttttccata cctgacacgt tccttgctga aacaaataaa ctaatctttt
     2581 ctaagatttc attaaactca tctctctgaa agtcgtttgc tgcatacata aactcatcaa
     2641 taggcatatt tatcgcattt aaagctgaca taaacttact aattgtcaaa tctgtatttt
     2701 cacgttcaaa gcgggaaata tgagatactg atacgcctaa ctttgcgata tcttttaaga
     2761 ctaatcccct agactctcta aatttcttaa ataattttcc ataatctttc ataaaaagca
     2821 cctcttttgc atatacgaga atttcccaga taaacttaaa agtattatat catatagtga
     2881 gataggaggt taatttctat gaataaagaa agttttttag ctatcttact tctaattttt
     2941 gaaagcatta ttgtaattgc tgttggctaa acaaatagaa aataaagaca ccacaaaagt
     3001 tagactttcg atgtctaact tttgtggtgt agttaaggta tgatgttgtt ctctaataag
     3061 ggtataatat aaaaaagact ctatgatttc tgtagtaggt aaaaccacta tagagattat
     3121 agagcttttt gagtgtatac aaaaactagt tctttattgg aacaaagtca acaactaatc
     3181 tagtattggt tgcagcggca atttcttcca atgttttata tgttggatta gtggtgccat
     3241 tctctatacg tcactttgag aaggtaaatt ttaaaatcct ctttatcata actttttact
     3301 aaaatagcca gaacatcaca ttctactatc attcttattt ctcatcttcg tccattgaaa
     3361 gcacagacaa gaaggcttct tgtggtacct ccaccgaacc aatggctttc atacgtttct
     3421 taccagcttt ttgtttttcg aggagtttac gtttacgtga aacgtcacca ccgtaacatt
     3481 tagccaagac gtttttacga agagctttga tatctgtacg ggcaacaatt ttttgaccaa
     3541 tagccgcttg gataggaact tcaaattgtt gacgtggaat aattttctta agtttatcaa
     3601 cgataagttt tccacgttcg taggcaaatt ctctatggac aataaagcta agggcatcga
     3661 ccttatcacc attaaggaga atatccattt tcaccaattg tgaacgacgg tactctgaca
     3721 attcatagtc aaaacttgca taaccacgag ttgatgactt caatttatca aagaagtcaa
     3781 agacgatttc agcaagtgga atttgataga taacgttaac acgattatca tcaatatatt
     3841 ccatggtttc aaaatcacca cgtttacgtt gcgccaactc cataacagca ccaacatact
     3901 cttgaggaac cataatttga gctttgacat aaggctcttc aatggcatca atacgtgtag
     3961 gatctggaaa ttcagatggg ttggacactt caagcatttc accgtcagta gtgttaacat
     4021 ggtaaactac tgatggtgca gtcatgatga gatcgatgtt aaactcacgt tccaaacgct
     4081 cttggataac atccatgtga agaaggccca agaaaccaca acggaaacca aaaccaaggg
     4141 cttgagacgt ttcaggctca aattgaagac tggcatcatt caattggagc ttttcaagag
     4201 cctcacgcaa gtcgttatat ttatttgact caattggata aagaccagca aagaccattg
     4261 ggttcatttg cttataacca tgaagtggtt ctgcggctgg attatccgca agtgtcactg
     4321 tatcaccgac acgagtatcc gcaactgtct taattgaagc tgctacataa ccaacatctc
     4381 cagtcgcaag gtagtcacgg ccaacagctt taggagtgaa aataccaacc tcagtaacgt
     4441 caaaggtctt gccattagac atcatttgaa tcttatcgcc cgttttaacc attccgttaa
     4501 ccacacgcac ttggagtatg acgccacgat acgcatcata aacagagtca aagataaggg
     4561 cttggagagg tgcttccaca tcaccttggg gcgcaggaac tttctcaaca atttgttcga
     4621 gaatctcttc gataccaatg ccagccttag ctgatgcaag cacagcttcc gaggcatcta
     4681 atccgataac atcttcaatc tctgtacgta cacgctcagg atctgccgct ggaaggtcga
     4741 ttttattgat aactggtaag atttccaagt cattatcaag tgccaagtaa acattggcaa
     4801 gtgtttgtgc ttcaatccct tgagctgcat ctaccaccaa gatagcaccc tcacaggcgg
     4861 caagggaacg tgacacctca taagtaaagt ccacatgtcc cggtgtgtcg ataaggtgga
     4921 aaatataagt ctcgccgtct ttagctttgt agttaagctc aatggcattc agtttgatag
     4981 tgataccacg ttcgcgctca agatccatac tatcaaggag ttgtgcctgc atctcacgac
     5041 ttgatacagt ctcagtcttt tccaagatac ggtcagcaag cgttgattta ccatggtcaa
     5101 tatgagcaat aatcgagaag ttgcgaatct tctcctgtct ttgttttaat tcttcaatat
     5161 ttggcatttt attctttcct aattcttact tgtgattgtt aaaaaacgaa ccgtcacctc
     5221 ctattataca aaaaagacag gcatttgcct atctctaata tctgctttat gactgcattt
     5281 agtccttctt atttcttaaa attatcattg tagtgcttat taataatagc tgaacgcttg
     5341 ttctctattg aactacttga aaatggagct aaaccaaagg ctagtacaat aattcccaat
     5401 agaataagac taaaaaatgg gtgctcagca atatagtgta agatgtctga tatgggaatc
     5461 cacctttaaa aacataatta tttataacta tattatcaga aacattatgt tttatcaagc
     5521 aaaaaaagag agccattcgc tctccctttt aaccttaatg gaattgcata ccaccatcaa
     5581 cgatgattgt ttgacctgtg atgtagtttg agtcaggtcc agctaggaag ctaactgctg
     5641 ctgcaacatc ttcaggttct gacaaacgtt tgagggtaat atctttagca aaagtttgca
     5701 taccctactc atcatcttta ccagcatttt accaacttcg tgggaaatgt caaacatcat
     5761 tggagtctta acgatacctg gtgcgtaagc atttacagtt atacctgaat cagctaagtc
     5821 acgcgccaaa gtttgagtaa taccacgaac tacgaattta gttccaccat atacagttaa
     5881 gttagagttc cctacaacac ctgcttgtaa agttgcattg ataattttac caccatgacc
     5941 aagtgattta aattgtgctt gggcagcttg tgcacctcag ataactccac caacattaat
     6001 gttaaatgta cgttgaaact gttcttcagt aatagtttca agggggtttt gttggtgcac
     6061 accagcatta ttaacaacaa cattcaagtc gccaaagtga tcaactactt tttggaaagc
     6121 tgctgctacc tcagcttgtt tagacacatc tgctacaacg gaaaatgcct tgtcttctga
     6181 caactcaaca actgcttttt cagcagtttc agcgtcatag tccaataccc cgactttaaa
     6241 accatcttca accaagcgtt ttgaaatcgc aaaaccaata ccttgacctg cacctgtaac
     6301 aatagcaact tttgacatac gaaatcctcc tctaccaatt gtagtcacaa gcttaaccac
     6361 aagccctatc tcaattggaa tatgctaagt taatcaagtt ctggcaaagt cattttcata
     6421 ggctttgtct taactcaatt aagattctac ccctttataa aagcgttgtt aataatttgt
     6481 catgcttttt gaaagcaaat aagatcacca ctagtgacct tatgtgtatt atttttcaaa
     6541 cttaaaccct agtgcttcca tatcacctag gccacctaag gtggtaacct tagtatatcc
     6601 tcgttctttc agtacacctg cagcaaattc agcacgagat cccattttac aataaagata
     6661 aattgaatcg tcttttttag ctggaatgtc agctgtgaaa aactgcgtgt gaggtattaa
     6721 taaagcatcc ttaacatgac cttctgcgta ctcttctgga gtcctgacat caattaatag
     6781 tccatcctga gctaattctg attgaatctg tgctatatcc atcctactca ccaaaccaaa
     6841 tcttaatttc tcgagccgca gattcttctg aatcagagcc atgaacgata tttggaatca
     6901 tgtcaccatc tggtgctgtt gcaaagtctc cacgaatcgt tccaggagca gcatccccag
     6961 gattagttgc tcccatcata tcacgccatg acttaataac acctgggccg gacataatac
     7021 caataactgc tggaccactc atcatgaatt cagaaatact agggaaaaaa ggtttatcag
     7081 ccaattgggc ataatgttct ttaagacgtt cttcgtcaag catcagcatc tccatacgct
     7141 caataacgaa gccacgtcgc tcaattcgat caagcacttg accaattaga tggcgtttaa
     7201 cagcatctgg tttaataata aagaatgttt tttgcatatt cccaaccttc atcgttttct
     7261 ttccatttta tcataagaag tatcattttg cagagctaaa ccttgtatag tctaaaacta
     7321 tatccacagc aagaaattaa ctatttttca ttagttccca taagagataa tatagatgta
     7381 aatagacatt tcgaggtaaa tttaatgaca aaatctaaat tccaattagt cggttctctt
     7441 cttcgtcctg cggatctccg taaatacaag gacgaaatcg agcatcgtga cgacatccag
     7501 tatcctttct atgatgccct tcctggttat caagaaactg aaactgcatc tattaagtga
     7561 atgtggctga ccaaaaagct aacggaattg acatccttac cgatggggag tttggacgtt
     7621 ctatgtggca cttggacttt gtctggggac tcaaaggtat tgaacgctac attgctgagc
     7681 atggttatac ttttaaagac catgatggtg gtcaatatga aacacgtaaa gatatcggta
     7741 ttcgtgtcac tgagcctctc tcaggtaaaa accaccacta cctagatatt tacaaattgg
     7801 ttaaggctga agctggtgat gaagatacca aacaaactat ctggggacct gctcatacct
     7861 acactgaact tgctatcttt gatcaattgg ctgttcctgg acaagtctat gaaacaaacg
     7921 aagaactcaa aaaaggtttg attaatgtct ataaagaatt cttagatgaa tacaaggctg
     7981 ttggtggtaa aatcgttcaa tttgatgact gcctctggga actttttgac ccatcaaacc
     8041 ctgcaagttt ctactcagac ggcaatggtg atttggcaga attggccgat gaatttgttg
     8101 ctatcaataa tgaggttgtt gactatactc acgaacttgg tttaacggtt tggacacaca
     8161 actgtcgtgg taattatgaa atccgttctg cttctgaagg aacttacgaa gacatcgcta
     8221 agaaattctt ggcagagcaa cactatgacc gcttcttcct tgaatgggat agcgatacag
     8281 ctggtgatat caaagctctg gaagccctta aagacagtaa agctgaagtt gtatttgggc
     8341 tattgtcttc ttaaacgact gacctagatg acgaagaacg tgttctcgat ttgcttgaaa
     8401 aagcgagtca aatccttcca aaaaaacgtc tcttcccctt tcaccaatgt ggtttcgcct
     8461 catgtgactc aggtaatgag ctggcaacac ctcaacaatg ggctaaaatc aaacaaggtc
     8521 aagaaatcgc taagaaattc tttggctaat cgatatttct attcgctcct ctctaaaacg
     8581 aaaagccttc actcttgtga gggcttttta tgttagcatc aagcatctat aaaagtttgc
     8641 aaatccttaa gagctctttc tgcgattttt tcataacgct ctttcttgtc acgaatacgt
     8701 gggccttcta attctttgat aataccaaag ttaacattca ttggttgaaa atgtttgctt
     8761 tcagcatgtg tcacataata tggaaggcta ccgattgctg ttgtatgagg gaaaataact
     8821 tcatcttcac ccttaaagag acgggctgca ttgattccag caaccaaacc tgaggcagct
     8881 gattcaacat aaccttcaac accagtcatt tgtccagcaa agaacagatt agggtttgat
     8941 tttgattgga aggtctgttt aagcaagttt ggcgaatcca tgtaagagtt acggtgcatt
     9001 accccataac gaacaaattc tgcattttca agacctggaa tcatttggaa gacacgtttt
     9061 tgctctcccc atttgaggtg ggtttggaaa ccaacgatat tgtagaggct accagccgca
     9121 ttgtcctgac gaagctgaac aaccgcataa ggtgtcttga agtcaccatc acgtggaccc
     9181 atataatctt caggatactc caaaccaact ggtttcatag gaccgtagag cattgtttta
     9241 ataccacgtt tagccataac ctcgataggc atacaccctt cgaaatactt ttctttttca
     9301 aaagaattca aaggagcttc ttcagctgta gtcaaggcct catagaaggc catgaactct
     9361 tccttggtca ttggacagtt tagataagct gcttcaccct tatcatagcg tgacttaagg
     9421 taaaccttgt tcatgtcgat agttgcttta tcaacgattg gtgcagcggc atcatagaaa
     9481 tagaacccgt ctccaccgtt aagctcatga atcttttcag ctaaagcatc agaagttagg
     9541 ggacctgaag caataactgt aatagcatca tcaggaattt ctgtgatttc tttacggata
     9601 acttcaatta agggatgact ttcaatttca gctgtcactg cttctgcata gccctcacgg
     9661 tccaccgcca tggcaccacc tgctggcaca cggtgagctt ctccattacg cataatgata
     9721 gagtccaaac gacgcatttc ttcttttaga agccctacag cattggtcaa gctatctcca
     9781 cggaaagagt tagagcaaac caattctgca aaatttgttg tcttatgctg tggtgttgct
     9841 ttgaccccac gcatttcata aagttttact ggaataccac gtttggcaat ctgataagcc
     9901 gcctcggatc cggccaaacc agctccaatc acgttaatat aatctgcttt tgattgagac
     9961 atgacactaa tacctcttcg gaaacaagat gaaatcctgc tcccacaaat ctttcttcat
    10021 ttttactctt agtagtatag caaaaaactc ctcatctggc gactaggagt catctgtatt
    10081 taaaaggggt aaaatgatag tcactttagc accacccgtg ccattgtcat ttgcaagaga
    10141 aagactacca tagtgtaaac gaataatatc attggcaata gtcagaccaa ggccactatg
    10201 attgcgacta tgtctgcttt tatcctcttg ataaaatagc tgagtagcgt tttcaagaga
    10261 ttcaagggaa aatccaggac cagaatcaag gcatataaac ttgaattcat cttcttctac
    10321 cctagcggtc aggagcaact gactgccact gggtgtatgc tctacggcat ttgaaacaat
    10381 attcataata gctcgattca acaaggactt atcccaattg cctatgcttt ctttcgcaat
    10441 ttccttcttg tcaaatacca cattgatttg tttcgtttga gctaatgaca aggtttgatc
    10501 gtaaatgtct tcaacaaatt ccttaactgg aacttcttca agcgtcaggg tcttcttcaa
    10561 actcattttg ttgagttctg acaactcttt tacataagca tcaacctgtg caataccttt
    10621 ttgaaaatgc tctaacaagt ccgtttgatt ttcatccaag gacgtcatag ctaagagttc
    10681 cgcatttcca cgagcaactg ttaggggcgt ctttaagtca tgtgttaggg cagaaatctg
    10741 attttgttta tcttgctctg ccttccaatt ttccatcaaa gactcacgaa gtgctatacg
    10801 catatgatcc aaaccactta aaacctgatt aaattcctta attgtagact gagaagtttg
    10861 aaaatccaaa tcttgttggg aaattttttc agtaaccctt aatataggtt taagttgctg
    10921 actcaattta tttgcataat aaaaagttaa aataataaat attattaaga tagatacaaa
    10981 cattgaacca atcatcataa gatcagcatt gggaaaatgt tggttcatcc actcattacg
    11041 gtaccgaggt gatagttgat aattgacaat gactatgcca tctgatcgtt caaaagactg
    11101 aaaatagccg tatttctcac cgtgagcatt cttgaattgg taatttagta aggattcttc
    11161 ttgcaagtta acaggcatgt tagacttttt aagcttaaaa tctctagtta aaaagacata
    11221 actcgtgcca tcaggtaaaa tctcgggatt aaagacctta gaagtttcaa tatcacttct
    11281 cacagcagac aaatcactct caacttgatt tgctggaatc aaaactccaa aacgaaaaga
    11341 caagctgaac aaatacaaaa taagaagact gctgattaca gagagaactg taagactgac
    11401 gacataagat aacaagattg ttcttagaga gtgttctcgt ttttttatta gtgccacttg
    11461 taaccaatcc cccaaactgt ttcaatagga ttttgcccaa cttctttaag ctttgcacgg
    11521 atattcttga tatgttcagc cactgctgcc ggactgcctt tatcctcata gccgtacaaa
    11581 tgcgtgtaga tttgttcttt tgaaaagact tggcccttat tttcagctaa aaactggcaa
    11641 ataccatatt ccgactttgt caaatctaac aactgattct caatataaag ctcttgagca
    11701 gacaagtcaa actgaaactc cccaagtgaa agcttatggt gacgctcacg atgttcacgt
    11761 ctcaagtgag ctgcaacacg cgcttggagt tctttaactc caaatggttt gcaaatgtaa
    11821 tcatccgcac cataactcaa cccttggaca atgtctgctt cttgcgtttt agctgtaata
    11881 aagaggattg ggcaatccac ctgatttcga atctcatggc aaaactgtag accgtcaaca
    11941 tcaggcatca taatatccag taaaatcagg tcaaatcgag gtaaagagtt cttatccaaa
    12001 tctaaaacac ttgtaagccc tgtcacatta tggttttgga gctctaaagc ctttacaacc
    12061 aattgaacaa tatctttttg atcatcaata acaagtattc gagccatagc ctttcctttc
    12121 cttcaaagtt atccttatca tatcatctat agaagataac tgacaaggcg taaagtagat
    12181 aaatatgggt tgggtaaaaa acatagaaca aatattttga ccctttccct ctttgaccat
    12241 tataagaaag cattaaaggt gctgaaaata tttccatcca ttcaaagtat ttgaatatta
    12301 aatcgtaaaa agaaggtcta cttaaaacaa tcgccattag cagccaaacg agactaacac
    12361 tcataaaagc aaacacttct ttcataagat tcctatgaca aagatacata gcgataccgg
    12421 tcaaaagcaa ccacgttcct ccatcactga taaatgtatg gactggcaat actgtgaaat
    12481 tgagtaaatt tagtagaaaa ccaaacatag gtttgttcac acttagcata taaaaaggca
    12541 tcattaacca tggaagcaac aatggaaaaa gtaaagttgg tatcccttta aggtatttct
    12601 tttcttgaat ccatgcaatc ccttgaagag caacgagcaa aattgcgaat gacgacagca
    12661 tcatattttg tggaaagaaa ccatctggtc taactagagg atgtagaaaa ttatagaatc
    12721 caacttgaat cagtcccatc acaattgcta aagaataaat ctttaggaag tatttcttcc
    12781 ggttatgggt atgaataaaa ccctcaatca ca
//
