LOCUS       c00016_JAJBOP0..       21749 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJBOP010000023.1 Bifidobacterium breve strain MSK.23.143
            NJBAFHED_23, whole genome shotgun sequence.
ACCESSION   JAJBOP010000023
VERSION     JAJBOP010000023
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 03:46:16
            Original ID  :: JAJBOP010000023.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 21749
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     cand_cluster    1..21749
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-i"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..21749
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03882))"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     protocluster    1..16772
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3782:6772]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3783..6772
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..16772
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     CDS             complement(3..227)
                     /locus_tag="ctg16_1"
                     /transl_table=11
                     /translation="MAGMIRAQARRIGMGLLTMPVACGIAVAAAGIMVSGVWSRTQTLT
                     VVNWLAQLMVIGAGVCVAVALTGDPLVEAS"
     CDS             complement(360..1187)
                     /locus_tag="ctg16_2"
                     /transl_table=11
                     /translation="MTDHIDETTDRLTDGTPDGHLLAALDAVERSHSEDAPPAAAVMAR
                     IRSSRSPLDGPAWSWARSLRLFMLLLGRQSRVVPWQVVPATLALMAFAGLGARFFAVGW
                     GATVVSRAFCSMVLAGVLLSVTMAFGDSRADMISSATPLGTGAVTLVRLVFILACDVVF
                     GLMVTAVMGAQGYGTFGVLLVGWLSPLLLVAGVGAMLAIRFSTGVGFGVGLLLVAVIRT
                     DLLGLTGLPAAGWIDMTRPFGQPLLAVTGLMACAAAVAFSGRLSEARMAAAAV"
     CDS             complement(1194..1772)
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 118.9;
                     E-value: 3.1e-36)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg16_3"
                     /transl_table=11
                     /translation="MTSPGGAATRDGDLLARVASGDERAFETLYGRYAAAVRAFVRVRV
                     PDAGTAEEVCADVWLGCWRSARAFRGDAKVLSWLLGIAKRQIYMRVRRVRPNVTALDDA
                     PEPRDDGPSPETAVLSEAGVDDLTALLRRLPVELVETATLAWLHGLSYRQIADLSDVPE
                     GTVKSRISRARRLLRAQLDRQNDADGKER"
     protocluster    1477..21749
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[11476:11749](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(11477..11749)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
     cand_cluster    1477..21749
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="2"
                     /tool="antismash"
     CDS             complement(1890..2903)
                     /locus_tag="ctg16_4"
                     /transl_table=11
                     /translation="MLYLSAFTVPFLFALALWPVVSVALTVPVLAMLYHRDNRLGLPAI
                     LSAYGTVLYAIGLLCLTLYPLPADPVAFCAVHHLKPQLDLFRFVADIRTDGLDAVLQIV
                     MNVVFFLPLGFIVRRVFHRGLPTATVAGFLVSLLVETMQLTGTLGVFPCAYRLFDVDDL
                     VWNTSGALAGYGCALAFDRLLPMRESDAATVTHPGLVRRLVAFLVDMGLVMSAALPLAV
                     AANVIHALVSGVRPGAAADRVLGGLGFSGLMFLLMLFVFEVLVPWLRDGRTLGGGYTHM
                     TCETVPRSGVRRILFYMARFVVFACLALAGIPWQPVIALALLTFWMAFRRMPYDLI"
     CDS             complement(2905..3774)
                     /locus_tag="ctg16_5"
                     /transl_table=11
                     /translation="LISINVEIFKKELLKNLNAQIDYFSPLFWINDSERKQFPWGPLVE
                     LLQIINTLTEEDILKYFDLDKLAIIGRELWNHRFPFNPYILLGRSILSDLCIRNNKTRI
                     LWADIRNNDTIRATEEPLLWCQIPQLERDYLAECLQKKDSSLLYKSSLISYLKARSEGR
                     LNDRVSAYYLTHLIIYCTNYGKRNFFPLHVRDILFQDAQAVAKESFSKKNYDLLAEAEA
                     SKCALGLHDQHTLKYAMYLFGLFSRYRCIPCFEIEDFTSLSKKDKFRLSYHTMLASSLL
                     VSILSRQE"
     CDS             complement(3783..5141)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     288.9; E-value: 1e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_6"
                     /sec_met_domain="LANC_like (E-value: 1.2e-41, bitscore:
                     134.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKQDQSKFLPPEIEKQFFYIIDELCHRLIDPKQLKSIVDQPGNH
                     EPLFDTSVWAPCTISHGLCGTSIFYSILANKYESFRAVAHNHLLLATSTINWCINGGVM
                     GGPSGLLAAAQIASRSPMDYSKLREQLTAWICRCQLYLINRYRSSLGNGVPWLAYDIMN
                     GICGNLRILLDENSTNARETINLSVKYLCDLVLTSNSQGMPGWWVPGNLQPTKQDENEY
                     PDGDLNVGVAHGAAGILGTLVSVFNYGYTDTRVMDSIKRIMEWTFHWTQHADDFDYWPA
                     RIPTNCQIQDDVLSPLPTRAGWCYGTPGIAVEMLRASTLLDDVDTTGHIIDILSSHLSS
                     PTNQWHIAGPTFCHGYAGVLYSVFKAWTLCGSEVLRNIGSNMANNLLAMADECSPFVYQ
                     HWMYSNTPSHKINLKKLDNVGLLEGSSGIGLVLYSICNQGDSSANWDRVFALS"
     CDS             complement(5147..6772)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     316.3; E-value: 6e-96)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_7"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.7e-40, bitscore:
                     130.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.9e-18, bitscore:
                     56.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLPKYVEKQFLNPIFEPDEYSAVINYPTRSDAAANLIDTPIAG
                     ERIISVNIPEENNEHCISLSQIGIRANKEGLYAVDLYTGQKIRIRAHNTVYPPAQAPNE
                     VRLLIEIMNEGARLWNPWSWNSLDSFPYRPRVRYGHIILSSRSWRLDELRESELASCKH
                     WREKWNVPRYCLAVSQDMRLLLDLDNPLHQTLLINESRKDKQLLVQEIPAGGNNPDAVW
                     GWMRKDGQSICSEIVFNFHKIDHKFSNSSTSMIPYRKIISRNNHIFLPGNENWLSCRIY
                     MPPENMVNYLKNNLTDILDCFNSSTVKHSFFVRYADRQGTHLRIRINGNDTDFNRLTSI
                     LVKSIVDGDARTYDFNEYIPEVNRYGGIQMMELTHQCFTTDSMNALQQIDKKGMEYDLD
                     SLAALCVMLTGFGNGYAKSKSFDLQEGKRWADYLNLSTSHDKEYQKNRKIWIESIKSVI
                     LHESKQVSKLDDLYKAYRDLGYMMKKSCNNYTATSSPTRVIGSHLHMCLNRRYGPNPEI
                     EDRLLRIAQSVLTSINQSIKYGEF"
     CDS             complement(7006..7251)
                     /locus_tag="ctg16_8"
                     /transl_table=11
                     /translation="MLNWQFIYRKYSRKIVKACPHCNIIIMNLLNNMGLMKRFQFSILQ
                     IPQKELVCQMTINIPNIQIRLALAQIIISMRSMNIT"
     CDS             complement(8324..8500)
                     /gene="allorf_08324_08500"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_08324_08500"
                     /protein_id="allorf_08324_08500"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MNTAILEKPTVDVMDIDLDIDVEDLPVEQIDQIRLTSISLCTPGC
                     TSPNGGSGCSFCC"
     CDS_motif       complement(8405..8500)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MNTAILEKPTVDVMDIDLDIDVEDLPVEQIDQ"
                     /locus_tag="allorf_08324_08500"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8324..8404)
                     /prepeptide="core"
                     /locus_tag="allorf_08324_08500"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-10.80"
                     /molecular_weight="2420.8"
                     /monoisotopic_mass="2419.1"
                     /core_sequence="IRLTSISLCTPGCTSPNGGSGCSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNTAILEKPTVDVMDIDLDIDVEDLPVEQIDQ"
                     /leader_location="[8404:8500](-)"
                     /alternative_weights="2438.8"
                     /alternative_weights="2456.8"
                     /alternative_weights="2474.9"
     CDS             complement(9283..10926)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 286.4; E-value:
                     7.9e-87)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_9"
                     /transl_table=11
                     /translation="MTLLLPKYMTNFFQNGVFQVPQWPVIAGMLLLVTASGAISALQNY
                     QLQSTGEDIVRDARLALSKHLLRLPIREYDQRDSGDLLSRVSNDTSQLRNAFMQCTSAL
                     ASGFITVIGSAAFMAMLDPILFGTAITLLLTVFTLMLLSAKFIERASYDSQYTLGDLTS
                     TLNRDLAGIRTIRASNGFENENKVIAALINHVRLSGLKIARIQSIVNPLATIALQLAAI
                     IVFGLGLWRVTTGLLSVEKLTQFIMLLFISISPLSQIIYAGSQIGNSMAAMNRIREILD
                     IPEEKDPDTVVTTINEHMPLAHSSPCPPAVEFQHVYFSYESKPILHDLNLSISQGSVTA
                     LVGPSGAGKSTILQLIERFYDPSSGNINVLGKDITTCDRDDLRSHIAYVEQDSPALSGS
                     IRENLLLGSNDCSDDECRRALKSVNLSHLLDRSDKGLDMQIGENGIMLSGGERQRLAIA
                     RALLSTAKIILLDEATANLDADNERLITRLLAQVEGRTFIIVAHRLATIIDSDLIYVIN
                     HGRVIGSGTHKQLFENIPLYHNLATKQHIA"
     CDS             10955..11089
                     /locus_tag="ctg16_10"
                     /transl_table=11
                     /translation="MSASRPRYFRRGEIRLYMEAGFMCMVSSWSLTVIAYLSVRNWFW"
     CDS             complement(11477..11749)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_11"
                     /sec_met_domain="PF05402 (E-value: 2.8e-11, bitscore: 35.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.9e-16,
                     bitscore: 50.9, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQADDTQTSISLRNQISLYPKEGGAIVFVNDTGEYLQVNEIGRII
                     LDGLMCGKTVEDCTNKIAEEYQADRQIIARDADRFLADMGKHVRL"
     CDS             complement(11736..12704)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_12"
                     /sec_met_domain="Asn_synthase (E-value: 2.5e-21, bitscore:
                     68.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLIKIGRVVDGNRSFEPAAGYPNREIPEEPVYWSDIEGYLSRIS
                     EMEADASRIHVTGFGGDELFASMPSSSWSCLREHPLRLQDIRRQYSADYRVPPYQAILD
                     LTDGTDLHEELRSSFLDAEQGHDHRSSPCGWHDAIRIPEFLTAKARNILYGAVESQLKH
                     ADIRPLNPDRSRHQALYSLSMQARMLNQVNRTFASNDITFRSPYLDHGIADYALCAPIS
                     ARTEGNLHKAVLYRALKGIIPETIFRRPVKGDHSYSLYLAWQRSKDALLDSIAGGVLDE
                     EGLIDMPAIRRRASMPMPDITFLFEMQRVAAVERWLRYASR"
     CDS             12817..13431
                     /locus_tag="ctg16_13"
                     /transl_table=11
                     /translation="MAAESTPPDTSADSGASLRHSSAIVRKRLLSDAKISLLGTCFAGE
                     GSALVYRGLLDLSRCSMVAAGMECMFLHGDLSPRRLSGSEGSKSMTMRSRSRSAFVMLA
                     SREALSDRSTSSSETVQNTRSPLSRGTWTHVPSSLMLMEAGSFEQFVGFPPRTITVRFG
                     FLCVNGITFPYPDTARDHQYMQGFGQFDPQGNGALAPPTST"
     CDS             complement(13380..13559)
                     /locus_tag="ctg16_14"
                     /transl_table=11
                     /translation="MHRHAIRSHIQSMRRTKMKDYVPPAVEVIASFKEATNGVWFGNYV
                     DVGGAKAPFPWGSN"
     CDS             complement(13680..13997)
                     /locus_tag="ctg16_15"
                     /transl_table=11
                     /translation="MTELQNLLTVKLHALAPIGVLKMRFAIALLPNPKALIMDEPLQTL
                     DRSGTNWICEQIRKQANRGVAVLIASEPDSRLRPITDDVVVLDKGTVVKEGSRGQLWKE
                     D"
     CDS             complement(14023..14169)
                     /locus_tag="ctg16_16"
                     /transl_table=11
                     /translation="MHIHLWQTLWHIPYTKKRCECNARSHFTVPVLLGRNLSSLEGALG
                     RNA"
     CDS             complement(14609..15316)
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 168.2; E-value:
                     2.4e-51)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg16_17"
                     /transl_table=11
                     /translation="MKDARDDIIKVMLVDDMRGARTGFMMMLNNDPNIIVSSQAADGAQ
                     AIEFLRQSPQQLPDVILMDVRMPVMDGIEATGIIKEQFPQIQILILTTYDEDDYAFDGL
                     ARGASGFLLKDATPKQLRDAVHAVHNGDAVLTPRITGEVLNRGVRPISDNTRIKLLRSL
                     FDGLSKREYEVAELVAAGLSNQEIAEHLFIETASVRRTVSRILARMHMRDRVQIAIAWY
                     QSGLDQITGGKPA"
     CDS             complement(15333..16265)
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 102.9; E-value: 3.3e-31)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg16_18"
                     /transl_table=11
                     /translation="VLYLCIRLPLYAQAMCDLAMICMIAMQYMHPASLQPQYLALLYSV
                     ALAGIASSLLSIARDRRTANRLLSEARRKAAILAEEKNRTERRLRMANELHDSVGHGLT
                     SIIALSQGGEDCIRNGGYSDSQLADALAEITSIAKDSLGDTRRILKVFNEEESQPSLEQ
                     VGLEPVNQDDILRLRDWDDIRPVLEHIRSTGIIVVFTETGRRVEDPRRSDLCFAVTREA
                     LTNALRHGAGLTRIAVSWNHYRDGGTAITIRNDGHVSGHGTTGEASGQSGKPTGGTGLQ
                     RLSQRLAKMGGTLSYGPYGNGWAVKALIP"
     CDS             16333..16494
                     /locus_tag="ctg16_19"
                     /transl_table=11
                     /translation="MNSKASNATGLLNLNVTFMAPKTSSMRKYHIPAPSLRNRINEYPV
                     PIAIRSST"
     CDS             16782..17795
                     /locus_tag="ctg16_20"
                     /transl_table=11
                     /translation="MTVAYRGLPAPLAERMLQAGLFDILSAIGAGTRPRAMRYAHDHVV
                     WPLACSRRWAARNLTRGLRPPPACHALRLRSLRRVPRRSRACAATANQHAVFATARIVA
                     VHASGLSAYAHGRRVVSEMETTRKGPMDMNDMVDTRTTGTGLAKRVRDGFLQDRRELGP
                     AQAADKWFAPLMDRWNGLLSRDEGGFSHEERVTLAVLMTEYLSMRDALILASLHEMGGG
                     ELHMLYAKPHSMESAAVVMRELSRAFKDADYQPDTRRGERATALLESVTADAPDGYEAQ
                     PMASCAYLLWMADRSTAAAVRALKALALDDDCSLASLVLAASEHGIRPAWTERRRH"
     CDS             17885..19444
                     /locus_tag="ctg16_21"
                     /transl_table=11
                     /translation="METAIIERPVMADEGMDESNIVMLDVGLIDPNPANPRRDVGDVSE
                     LADSIRAQGIRQNLLVTPTLQGRYLLVIGHRRLAAAKLAGLSRVPAVVADLSEREQREL
                     MLVENSQRADLTVIEEADGYQGLLDLGVGVDEAAQRTGRSVSLVRRRLKIAAIGENARS
                     KAGTAQLSIDDWETIADFDRYPDLQERLAEAAGGKNWNMAVKHARQERTWREWLDTARA
                     ELERMGIDAADEQPNTDNWYDSPKGLRRTTMLTTGDIAKAIDAWRDSHDGATPVVGVRA
                     EGASWARGIVLYETVDEEAETAAREAREARWREEREREERETAPAKEFARASRDLRIAF
                     VTHLMELKSQPKGIGRAVALLSARFALDALTEGFDQWDGHAEDVWEQITGIDTTGDDAD
                     AEEPEGETEDPLRASVTAMIAGDPQRAAFGLLYALAEERVSWETWRGAATIAEHAAPLY
                     EALETLGYRTSDTETEALNGSLAPIDDNDNGGDAGIRQDGEPDDDGTSQTDDASGKPED
                     AE"
     CDS             complement(19560..19982)
                     /locus_tag="ctg16_22"
                     /transl_table=11
                     /translation="LDWTRRGCDSVSRVLAATLDDIGDIREVTAMPMLLVMLGLSLATG
                     VIRMLMRGVASCLALLAHPLRLVVFLANSVFTAFAMLSGLLMLAFLLMHFLAGSDAPAL
                     DGSFALIVAAFLTAVLASMLMDWCDARLRRRSARHG"
     CDS             complement(19921..20427)
                     /locus_tag="ctg16_23"
                     /transl_table=11
                     /translation="MAKPRERNRAMRAIADNALDAELEALRRKRGELSRLGILLDDMRW
                     AAERFRDAAQSFCDDHHMPRAQLVRTLRMEPRETGMAFHAVTPDYGQANPADSHGEIHD
                     GEDSAVESGGRPASAADAPETALTEDNAATENAADAVDAGTSGSIGLDPEGLRFGFPRP
                     GGYAG"
     CDS             20716..21120
                     /locus_tag="ctg16_24"
                     /transl_table=11
                     /translation="MGWKGNRSRTIRKAVTFSEEEWRWVADSLKVENRQRIQAGLRPVG
                     WMTFARNRIRCAHRVNITVPANLHDVSAQLARIGNNVNQIARHANTTRETDLAMLSRVF
                     DELRQAERLVAGLSIRVETDVDPKGVPEWL"
ORIGIN
        1 tcgctcgcct cgaccagcgg gtcgccggtc aacgcgaccg ccacgcacac gcccgcgccg
       61 atcaccatca gctgggcgag ccagttcacc accgtcagcg tctgcgtgcg cgaccacacg
      121 ccggatacca tgatgccggc ggccgccacc gcgatcccgc aggccacggg cattgtcagc
      181 aatcccatgc cgatgcgtct ggcctgcgcg cgaatcattc ccgccatgcc gtccctcctt
      241 gaagtgcgaa gctcgacggc cgttccttat cgtccgtcac ctgataggta gcggacggca
      301 gccgcatggt tcacgcgaca cgccgaacgg ccgccggagg cccgtcggct tcaatccggt
      361 cagacggccg cggccgccat gcgcgcctcg gacaatcgtc cggagaacgc caccgccgcc
      421 gcgcacgcca tcagacccgt gacggccagc agcggctgcc cgaatggccg ggtcatatcg
      481 atccagcccg cggccggcag gcccgtcagc ccgagcaggt ccgtacggat cacggcgacc
      541 agcagcaggc cgacgccgaa gccgacgccc gtggagaaac ggatcgcgag catcgcgccc
      601 acgccggcga ccagcagcag gggcgacagc catccgacca gcagcacgcc gaacgtccca
      661 tacccctgcg cgcccatcac ggcggtcacc atcaggccga acacgacgtc gcaggcgagt
      721 atgaacacca gccggaccag cgtgaccgcc cccgtaccca acggggtggc cgacgagatc
      781 atgtccgcgc gggaatcccc gaacgccatc gtcacgctca acaacacgcc ggccagcacc
      841 atcgagcaga acgcgcggga cacgaccgtc gcaccccagc cgaccgcgaa gaaccgcgcc
      901 cccaatccgg cgaacgccat caacgccagc gtggccggca ccacctgcca cggcaccacc
      961 cgcgactgcc ggcccagcag cagcatgaac aaccgcaggc tgcgcgccca cgaccatgcc
     1021 ggtccgtcca acggggaacg cgacgatcgg atgcgcgcca tcaccgccgc agcgggaggc
     1081 gcgtcttccg aatgggatcg ttccacggcg tccaatgccg caagcagatg cccgtcgggc
     1141 gtcccgtccg tcaagcggtc ggtcgtttcg tcgatatgat cggtcatcgg gattcaccgt
     1201 tcctttccat ccgcatcgtt ttggcggtcg agttgcgcgc gcagcagacg gcgcgcacgc
     1261 gagatacggg atttgaccgt gccttccggc acgtccgaca aatcggcgat ctgccggtac
     1321 gacaggccgt gcagccacgc caacgtggcc gtctccacca gttcgacggg cagccggcgc
     1381 agcaacgccg tcagatcatc cacgcccgct tcggacagca cggccgtctc cggactcggt
     1441 ccatcgtcac gcggttcggg cgcatcgtcc aacgcggtca cattcgggcg tacgcgccgc
     1501 acgcgcatgt agatctgccg tttcgcgatg cccagcagcc aggacagcac cttcgcgtca
     1561 ccgcggaacg ccctcgccga ccgccagcaa cccaaccaca cgtcggcgca cacctcctcg
     1621 gccgtgccgg catccggcac gcgcacgcgc acgaacgccc gcaccgccgc agcgtaccgc
     1681 ccatacaggg tctcgaaggc acgctcgtcc ccggaggcga cccgcgcgag cagatccccg
     1741 tcacgcgtcg ccgccccacc gggcgaggtc atgtcatcct gcgtatgcgg ctccttccac
     1801 agcacatcgt agacggatgt tcatcggtat atgtagcggg gaacgcgccg gcggttcatg
     1861 gcacgtgcat cgacatgccc ggaggggcgt cagatcaggt cgtagggcat gcgcctgaac
     1921 gccatccaga acgtcaggag cgcaagggcg atcacgggct gccaaggtat gccggcaagc
     1981 gccaaacagg cgaacaccac gaaccgtgcc atatagaaca ggatccgacg tacgcccgag
     2041 cgcggaaccg tctcacaggt catatgcgtg tagccgcctc ccaacgtgcg cccatcccgc
     2101 agccagggca ccaacacctc gaagacgaac agcatgagca ggaacatcag ccccgagaac
     2161 cctaacccgc ccaacacgcg gtcggcagcc gcaccgggcc ggacgcctga gaccaatgcg
     2221 tggatgacat tcgccgcgac ggccaacggc agtgccgccg acatcacgag gcccatgtcc
     2281 acgaggaacg cgaccagacg ccggaccagg ccgggatggg tcaccgtcgc cgcatccgac
     2341 tcacgcatgg gcaggagccg gtcgaatgcc agcgcgcacc cgtacccggc cagcgcgccc
     2401 gacgtgttcc acaccagatc atccacgtcg aacaggcgat acgcgcacgg gaacacgccc
     2461 aacgttcccg tcaactgcat cgtctccacc agcagcgaga ccaggaaccc ggcgacggtg
     2521 gccgtgggaa gcccgcgatg gaacacacgc ctgacgatga acccgagcgg cagaaagaac
     2581 acgacgttca tcacgatctg caacacagca tccaacccgt cggtacgtat gtcggcgacg
     2641 aaccggaaca ggtccaactg cggcttcaga tggtggacgg cgcagaacgc gacgggatcg
     2701 gccggcaacg ggtacaaagt gaggcacaac aagccgattg catacagcac cgtgccatac
     2761 gcggacagga tcgccggcaa tccaagccgg ttatcgcggt gatacagcat cgccagcacc
     2821 ggaacggtca acgccacgga caccaccggc cacaacgcca acgcaaacag gaacggaacc
     2881 gtaaacgccg ataaataaag catatcattc ctgtcttgat agtattgaga ccaataagga
     2941 cgacgcaagc attgtgtgat atgacaagcg gaatttatcc tttttagaaa gagaagtaaa
     3001 atcttcgatt tcgaaacatg gaatgcacct ataccgactg aataatccaa ataagtacat
     3061 agcgtatttc aaggtgtgtt ggtcatgtaa tcccaaggcg cattttgatg cctctgcttc
     3121 cgcaagcaga tcgtaatttt ttttggaaaa agattctttt gccactgctt gggcatcctg
     3181 gaaaaggata tcccttacgt gcaatgggaa aaaattcctt ttcccgtaat ttgtgcagta
     3241 tattattaaa tgtgtcaaat agtatgcact gactctgtcg tttaatctac cttccgatct
     3301 tgctttcaga tatgaaatca gtgacgattt gtataataaa gatgaatcct tcttttgcaa
     3361 acattccgcg aggtaatcac gctcaagctg aggaatttgg caccataaca agggttcttc
     3421 cgtagctctg atggtgtcat tgttccggat gtcagcccag agaatgcggg ttttattgtt
     3481 acggatgcac agatcggaaa gaatgcttct tcccagtagg atgtaaggat tgaaggggaa
     3541 tcggtgattc caaagctcac gtcctataat ggctaattta tctaaatcga aatattttaa
     3601 tatgtcttcc tctgtaagag tgttaatgat ttggagtaat tcgaccagag gtccccatgg
     3661 gaactgtttc ctttctgaat catttatcca gaacagcggt gaaaaataat caatttgtgc
     3721 attaagattt ttgagtaatt cttttttgaa aatctcgaca tttatgctaa tcaatattgg
     3781 tcctaagata aagcgaaaac gcgatcccag tttgcagatg aatcaccttg attgcatatt
     3841 gaatacaaaa ccaagccaat tcctgaagaa ccctctaata aaccaacatt atctagtttt
     3901 ttcaaattaa ttttatgcga gggtgtattg gaatacatcc agtgttggta tacgaaagga
     3961 gaacattcat cagccatggc taataaatta ttagccatgt tcgaccctat attccgtagt
     4021 acttcacttc cgcaaagtgt ccaagcctta aatacggaat aaagaacacc cgcataacca
     4081 tgacaaaagg tagggccggc tatatgccat tgatttgttg gcgatgaaag gtgactagaa
     4141 agaatgtcta tgatatgtcc ggttgtatca acgtcatcca gtaaagttga agctcttaac
     4201 atttcgaccg caattcctgg agtaccgtag caccatccgg ctctagtagg tagaggtgat
     4261 aaaacatcat cttgtatctg gcaattggtc ggtattcgtg caggccaata gtcaaagtca
     4321 tctgcatgct gcgtccaatg aaatgtccat tccataatgc gtttaatgga gtccataact
     4381 cgtgtgtccg tgtaaccata gttaaagacg cttactagtg ttcccaaaat tcctgcagcg
     4441 ccatgtgcga cgcctacatt taaatcgccg tcgggatatt cgttttcatc ctgcttcgtt
     4501 ggttgtaagt tccctggcac ccaccatccg ggcatgcctt gcgagtttga agtaagtacc
     4561 aaatcgcata aatattttac agacaaatta atagtttctc tagcatttgt actattctca
     4621 tccaataaaa tgcggagatt gccacaaatt ccattcatga tgtcataagc aagccatggg
     4681 acaccattcc ccaaagatga acgatatctg ttaattaaat acaactggca cctacaaatc
     4741 caagcggtta gttgctcacg tagttttgaa taatccatag gagatctcga tgcgatctgt
     4801 gctgctgcta gtaggcctga ggggcctccc ataaccccgc cattgataca ccagttaata
     4861 gtggaggttg caagtaaaag atgattgtgt gcaacagcgc ggaatgattc atacttattc
     4921 gctaatatgg aatagaatat agaggtgcca cataaaccat gactgatggt gcagggcgcc
     4981 catactgatg tgtcaaaaag cggctcgtga ttgccgggtt gatccacaat agatttcaac
     5041 tgttttggat caattaatct atgacatagt tcgtcaatta tataaaaaaa ttgtttctca
     5101 atttccggcg gaagaaattt tgattgatct tgtttagaca taattattaa aattctccat
     5161 atttaatcga ttgattgatg cttgtcagga cagattgcgc aattcttagc agcctatcct
     5221 ctatttccgg gtttggacca taccttcggt tcaagcacat atgtagatga ctgcctataa
     5281 cacgggtcgg agaggaggtt gcggtataat tattgcagct ttttttcatc atatatccca
     5341 aatctctata tgctttatac aaatcatcca atttcgatac ctgttttgat tcatgaagga
     5401 ttacggattt tatggattca atccatattt tccgattttt ctgatattcc ttatcgtgag
     5461 aagtcgaaag atttaaataa tctgcccaac gttttccctc ttgcaaatca aatgatttcg
     5521 atttggcata tccattccca aatccggtca gcatgacgca cagcgcagcc aatgaatcaa
     5581 gatcatattc catccccttc ttgtcaatct gctgtagagc attcatagaa tccgtagtaa
     5641 agcactgatg tgttaactcc atcatttgaa tgccgccata tctattgact tcgggtatgt
     5701 attcgttaaa gtcatatgtg cgcgcgtcgc catctacaat tgattttaca agtattgaag
     5761 tgagtctatt gaaatccgta tcatttccat taatccttat tcttaggtga gtcccttggc
     5821 ggtctgcata cctaacaaag aaggaatgct tgacggtaga actattgaaa caatctaaaa
     5881 tatcggtcag gttatttttt agataattaa ccatattttc cggcggcata tagatacggc
     5941 atgataacca gttttcattt cctggcaaaa aaatatggtt attccgtgaa ataatcttcc
     6001 tgtatggaat catactcgta gaggaattag agaatttatg atctatttta tggaaattga
     6061 atacgatttc gctgcaaata gattgcccat cttttctcat ccatccccat actgcatccg
     6121 gattattgcc gccggctgga atctcttgaa ctaggagctg cttatcttta cgcgactcat
     6181 tgattaaaag agtttgatgt aatggattgt ccaagtctaa aagtaatcgc atatcctgac
     6241 ttaccgctag acaataacgt ggaacattcc acttttccct ccagtgtttg catgaagcta
     6301 attcactttc gcgaagttca tcaaggcgcc aacttcttga agataaaata atatggccat
     6361 atcgtacgcg aggtctataa gggaaactat ccaggctgtt ccatgaccag ggattccata
     6421 aacgggctcc ctcattcatt atctctatta atagtcttac ttcattagga gcttgtgcgg
     6481 gcgggtaaac ggtattatgg gctcgtatac ggattttttg tccagtatat aaatctacgg
     6541 cgtacagccc ttctttgttt gcgcgtattc cgatttggga aagggaaata cagtgttcgt
     6601 tgttttcttc tggaatattt actgatataa tcctttcccc ggctatcgga gtatctatga
     6661 gatttgccgc cgcgtcggag cgtgttggat agtttataac tgcactatac tcatctggct
     6721 caaatatagg atttaggaat tgcttctcaa catatttagg taataaagac ataaatcggc
     6781 cagtagtgct accggatgca tgtgatccgg ggtttgggcc aataaccaat aaatagtctc
     6841 cttccgataa ggcggacatg tcctttgacg caatggtgca atacagttcg gcgctttctt
     6901 gcgaatcttc cttatcgaat ttctcgtatt gaagtttatt tatgtcttca tccgtcagta
     6961 taacttcggt tttgttcttt gttatggcat catagaatag tgatgctagg taatgttcat
     7021 gctcctcata gatattatta tttgcgctaa agctagtcgt atttgaatat tggggatatt
     7081 tatagtcatt tggcacacca attccttttg cgggatctgt aagatcgaga attggaaccg
     7141 tttcatcaaa cccatattgt tcaacaaatt cattataata atattgcagt gaggacatgc
     7201 ctttacgatt tttcgagagt atttgcgata tatgaattgc caattcagca tctttttgca
     7261 cgcttttcgg aagacctatg gatattccgt ttccgacctg aaaatgaaca taagagtcgg
     7321 atttctgtat ctttcccatg gcttttatgg tgtcttgata cgattgcata cttggataag
     7381 tgtatcctga gatggaatgg agcttattat ttatttccac taattgctcc actatgtctt
     7441 tatcttcttc ctgaattgcg atgtgagata gtttctcaag cagttctgaa atacgttcct
     7501 caccattatg ggctggtctc aaatttgagt aaaatatatc cgaattgaca agacgcttaa
     7561 tcaagctcag agaggtgtct tcatccacgt tgaattgtct tgatagtcga tcaagaatgg
     7621 ttttgacact gatgtcctta tcatttaata ggtcgtcgat aatgggcgtg catctgatgt
     7681 ccacacgctt attgcacata ctctctttgt taaccgtata tagtatgtaa tgattatgtt
     7741 gcttccttat taggtcattg cgatgcagca ttagttgcct gagaatagac gagtgctgtt
     7801 ccagttttct aattaatgga tttagccatt tgtaatcagc gtctgcatga atgatctttt
     7861 cctcttgtgt tatggttagt atgtcttttc gattaaatgt tcctatacca acttcggcga
     7921 ataaaccgaa gggagttggg cgactcaaag ctcgatttac gtatttactc gttgctaaca
     7981 ctattttttt cagctttcgt gctgatggta tgttctggga accagtaata gcgtcatgcg
     8041 cggattgata taaagaaggt gccgcatgaa tgattgcaag ggatatatac tcatttgagt
     8101 atatatccct taaatatgct agaagttcag ttttttgaga ttctaaagga ttgatttgtt
     8161 gcgttattga gaggtatggc agcgctgccg tgcgaattgt tatgttggga attgcgtcca
     8221 tggctttttt ctcttgtctc attgcaacac ctcttttgaa taaaaacagg tgggagatgg
     8281 aaacagggtt ttatcatctc ccacccgaac cttatctatt gcattagcag cagaaggaac
     8341 atccgctgcc tccgttcggg ctagtgcaac ccggtgtaca aagacttatg ctggtcaaac
     8401 gaatctggtc aatctgttct acaggcaaat cttcaacgtc gatgtcaaga tcgatatcca
     8461 taacatctac agttggcttt tcaagaattg cggtattcat gattcacctc ctttcttttc
     8521 ctgactatgc aattgtttgg caagaggaca taaaaatagt cctttaaaat gtttaactaa
     8581 ttgcatgctc ttggttagtt ggagttttcc ctccaccact atgctcgttc ttttgtgttg
     8641 gatattcaat cattcatcag tcatttgtca tcttgcgatg acagcttgaa ttgttctggc
     8701 tgtttccatt gggcttgtct tttgacgatg catgaccgga gtgtgtattc cgggcttttt
     8761 ctgtgtggga ggctgaatca gcgacctcat cgggctggga gtcatgtctt ctgttttgtg
     8821 gggttatcgt gtcatgatga tgaacatgtc ccgagatttt aaattcacga tatattgaaa
     8881 tgtgcgattt acgtgttttg ataggcgacg tcgaaggatt tggattacgg gccatgctga
     8941 agcgagagat tgaccgaatt gtagtacaag tgctgctttt ggtgcatgtt gtaatgatgc
     9001 tgaaatatgt gagtatgtcc cgtaattaaa ttagggaata ggagctagtt gttttggttt
     9061 ctgccagcgt atatatatat ggctttgtct ctctgaatag ctttcccgta taacgccttt
     9121 caagaaagct gtgcacagac cactgttctt atcgggcact ctttcagaca gtgtgtaagc
     9181 atcgtaatct catggtccgc ggtgttatgc aattattcga catggtcgat gacgttccat
     9241 aatttcgcgt tgcatataat ttggatgatt ctcagtccgt gatcatgcga tatgctgttt
     9301 tgttgcaagg ttatggtaga gtggtatatt ttcgaaaagc tgtttatggg ttcctgatcc
     9361 gataacccgt ccgtggttaa ttacatatat gagatcggaa tcaattattg tggcgagtcg
     9421 atgcgcaacg ataataaaag tgcggccttc tacctgagcc aatagccgag tgataaggcg
     9481 ttcgttatcg gcgtccaggt ttgcggtggc ttcgtcgagc aggatgattt ttgccgtgga
     9541 aagaagggcg cgggctatgg cgagtctttg gcgttctccg cctgatagca tgattccgtt
     9601 ttcccctatc tgcatatcga gacctttgtc ggatcgatct agcagatggg agagattcac
     9661 ggatttcaat gcccgtcggc attcatcatc gctacaatcg tttgatccga gaagtaggtt
     9721 ctctcgtatg ctgccggaca gtgccggtga atcttgttcc acgtatgcga tgtggctgcg
     9781 taaatcgtct cgatcacagg ttgttatgtc cttgccgagt acattgatgt ttccgctgga
     9841 aggatcatag aaacgttcga taagttgcag gatcgtgctt ttccctgcgc ctgagggccc
     9901 gacgagtgcc gtgacgcttc cctgggatat ggagagattc aggtcgtgca gaattggttt
     9961 ggattcatat gagaagtaga cgtgttggaa ttccactgct ggcggacagg ggctgctgtg
    10021 tgccagcggc atatgttcat tgattgttgt gacgacggtg tcagggtcct tttcttcggg
    10081 aatatccaat atttcccgta tacggttcat tgcggccatt gaattgccga tttgtgagcc
    10141 tgcgtaaatg atctggctga gcggtgagat gctgatgaac agcaacatga tgaactgagt
    10201 aagtttctct acggatagca accctgtggt tacgcgccat aatcccagac cgaacacgat
    10261 gatagctgcg agctgcaggg ctatcgtggc cagtggattg acgatcgact ggattctggc
    10321 gatcttgagt ccggacaggc ggacatggtt gatcaaggcg gcaatgacct tattctcgtt
    10381 ctcgaagccg tttgaagcac gtatggtgcg gatgccggcg agatcacgat tgagcgtgga
    10441 ggtaaggtcg ccgagcgtgt attggctgtc atagcttgct cgttcgatga atttagcgga
    10501 cagcagcatg agcgtgaata cggtaaggag cagggtgatc gctgtgccga ataggattgg
    10561 gtcaagcatt gccataaacg cagcggaacc gatgacggtg atgaagcctg atgcaagggc
    10621 tgatgtgcac tgcatgaatg cattacgcag ttgtgaggtg tcgttgctga cacggctgag
    10681 caggtcgccg gagtcgcgtt gatcgtattc gcgtatgggc agacgtagca ggtgtttgct
    10741 tagtgcgaga cgagcatccc ttacgatatc ctcccccgtg ctctgaagtt ggtagttctg
    10801 tagggctgat attgctcctg aggcggtgac gagtagcagc attccggcaa tgacgggcca
    10861 ctggggaacc tggaatacac cattctggaa gaagttggtc atgtacttag gcaggagcag
    10921 cgtcatagcg gctcctatgg ctccaaggca taggatgagt gccagccgtc ctcggtattt
    10981 tcggagggga gaaatcagat tgtacatgga ggcaggtttc atgtgcatgg tgtcgtcctg
    11041 gtcgttgacg gtcattgcgt atctttccgt tcggaactgg ttctggtgat ggtgtaccgt
    11101 ctgacggcat caggttcgcc gatgggtgtg ccgttggctt cgacccaggc gtgtgcgcgg
    11161 aagggacgat cggtgaaccc ggtgcaccat gtgacggatc ggcgagatat gcggcatgcc
    11221 gccgctgtgg agagcgaccg aagcagacaa ccctgctggc ttcggcatct gcggcttacc
    11281 gcgcatacgg cattgcggta acgttccgcc atgctggtgt cggccggcgg atatcgttcg
    11341 gaccacgttt caagccggcg gcagaactct ccgatttgct gtcgttccat ccgtctgccg
    11401 atgatgatgg caatcagcgc tatcaggcgg tcgtgaaagt tggctcgtgt gatcgcttcc
    11461 ggctgtagtg ggatgctcat agacgcacgt gcttccccat atcggcgagg aaacgatccg
    11521 cgtcccgggc gatgatttgt ctgtcggcct gatattcttc ggcgatttta ttcgtgcaat
    11581 cctcgacggt tttgccgcac atcagaccgt caaggataat ccggcctatt tcgttgacct
    11641 gcaggtattc accggtgtcg ttgacgaaga cgatcgcccc gccctccttg ggatacaggg
    11701 atatctgatt cctcagactg atgcttgtct gtgtgtcatc ggcttgcata tctcagccac
    11761 ctttccactg ctgctactcg ttgcatttca aacaggaatg tgatgtcagg catcggcatg
    11821 gaagctcgac gccgtatggc tggcatatcg atcagtccct cctcgtccag cactccgccg
    11881 gcgattgagt cgagcagtgc gtccttcgag cgttgccatg ccagatacag tgaatatgag
    11941 tgatcgcctt tgacgggacg ccggaatatc gtttcgggga ttatgccctt gagcgcccgg
    12001 tataacacgg ctttgtgtag atttccctcg gtgcgtgcac tgattggggc gcatagcgca
    12061 tagtccgcga ttccgtggtc cagatagggg gagcggaacg ttatgtcgtt ggaggcgaac
    12121 gtccgattaa cctgattgag cattcgtgcc tgcattgaca gagagtagag cgcctgatga
    12181 cggcttcggt cggggttcaa tggccgaatg tcggcgtgtt tcaattgtga ttcaacggcg
    12241 ccatatagga tattcctggc tttcgcggtc aggaattcgg gaatgcgtat ggcatcatgc
    12301 catccacaag gcgaagagcg atggtcatga ccttgttccg cgtccaggaa cgatgaccgt
    12361 aattcctcat gcagatcggt gccatcggtg agatcgagaa ttgcctgata gggtgggacc
    12421 cggtaatcgg cgctgtattg tcttcggatg tcctgtagcc gtagcgggtg ttcccgcagg
    12481 cagctccatg atgaggatgg catggatgcg aacagctcgt ctcctccgaa acccgtgaca
    12541 tggatacggc ttgcgtctgc ttccatttcg gagattcggc tgagatagcc ttcgatatcg
    12601 ctccagtaga ccggttcttc aggtatctct ctgttgggat atccggctgc gggttcgaat
    12661 gatctgtttc catccacgac ccggccgatt ttgatgagtg gcatccgaac gtcctcggag
    12721 attcgctcgg cccatcggga atcctgattc attggatcgt cgggtgtttc atgatacagg
    12781 ggcatacgaa ccccctcgct ggcgaagacg tatgtgatgg cggcggaatc cactcctccg
    12841 gacacatcgg cggatagtgg tgcctcattg cgccactcat ccgcgatcgt caggaaacgg
    12901 cttcttagtg atgccaagat ctcgttgctc ggaacatgtt ttgcgggtga aggttccgct
    12961 ctcgtatatc gcggcctatt ggatttgtcg aggtgcagta tggttgcggc gggtatggaa
    13021 tgtatgttcc tccatgggga tttgtcccct cgaaggctgt cagggagcga aggcagcaaa
    13081 tccatgacaa tgcgttccag gtcaagatcg gcgttcgtga tgcttgcaag tcgggaggcg
    13141 ctgtccgaca ggagcacttc atcttcggag acggtccaga acacgcgatc gccactcagc
    13201 agaggaactt ggacgcatgt tccctcgtca ttgatgctga tggaggcggg aagcttcgaa
    13261 cagttcgtcg gcttcccgcc gcggacaatc acggtacggt ttgggttctt atgcgtaaac
    13321 ggcatcacgt ttccctatcc tgatacagct agggatcatc aatatatgca gggtttcggt
    13381 cagttcgatc cccaagggaa cggggccttg gcgccgccaa catcgacata gttgccgaac
    13441 catacgccat tggttgcttc cttgaatgat gcgatgacct caacggccgg gggtacataa
    13501 tccttcatct tcgttctcct catgctctgt atatgggacc ggattgcatg ccggtgcatg
    13561 ccattccagt taacctgatt tggatggtac atccaagaat gtgtttggtg tttgtcatct
    13621 tcggatgaca aacaccaaac acatggacct tagggaagcg ggtgatccgc tggcgttttt
    13681 cagtcttcct tccaaagctg gccgcgggag ccctctttta ccacggtgcc tttatccagt
    13741 accacaacgt catcggtaat cggcctcagc ctgctgtccg gttcggatgc gatgagcacc
    13801 gcaacgccac gattcgcctg cttccgtatc tgctcgcaga tccaattcgt gcccgatcga
    13861 tcgagtgtct ggagcggttc gtccatgatc agggccttgg ggttgggaag cagagctatg
    13921 gcgaatcgca ttttgaggac accgatcgga gcgagagcgt ggagcttgac ggtgagaaga
    13981 ttctgcagtt cggtcatgtg aatgatcccg tcaagaagcg gatcaggcgt tccggcccag
    14041 agcgccttcc aacgaagata ggttccggcc gagtaatacg gggaccgtga aatggcttcg
    14101 ggcattgcac tcacaacgtt ttttggtata cgggatgtgc catagggttt gccacaggtg
    14161 gatatgcatc cggaatccgg gatatccagt cccaacagca tccggagaac agttgttttg
    14221 ccagcgtcat gcgctcccat cagaacggtg actcgacctg cataggcggc aaatgagatc
    14281 ccatgcaatt cgcgaccggc atgattgaat gagacgttct caaatgcgat gatgggtgaa
    14341 gccgaatcgg gcagctggca catcgttttc ctttcttcga ttgacccgag ccgcaataat
    14401 cgaagtcccc cccccctaac ggtttttgga tactgcccta tcttagggga tggcagaagt
    14461 gacgtgatat atgctaggtt tgttccgttc gcttgagcga tggacataga cagttaacca
    14521 gttcgctcta ttctccaata aaaggattgt ggtgtttgtc atctgaagat gacaaacacc
    14581 acaatccttg agatgaatat cgtgattttt atgctggttt gccgcctgtt atttggtcca
    14641 gccccgattg ataccaggct atggcgattt ggactcggtc ccgcatgtgc attctggcca
    14701 atatgcggct taccgtgcgt cgtaccgatg ccgtttcgat gaacaagtgt tcggcgattt
    14761 cctgattgga caagcctgcc gccacgagtt ccgcgacttc atattcccgc ttggaaagtc
    14821 cgtcgaatag gcttcgcagc agcttgatgc gggtgttgtc cgatatgggc cgaaccccgc
    14881 gattgagcac ttcaccggtg attctcggtg tcaataccgc atctccgtta tgcacggcgt
    14941 gtacggcgtc acgtagctgt ttgggggtcg catccttgag caggaatccg gatgcccctc
    15001 gcgccaatcc gtcgaaggcg taatcgtcct catcgtatgt ggtcaggatc agtatctgga
    15061 tttgggggaa ttgctccttg atgatgcccg tcgcctctat gccgtccatg acgggcatgc
    15121 gcacgtccat cagaatcacg tcaggcagtt gctgcggtga ttgccgtagg aattcgattg
    15181 cttgggcgcc gtccgcggcc tgtgagctga cgatgatgtt cggatcgttg ttcagcatca
    15241 tcatgaagcc ggtgcgcgcc cctcgcatgt catcgaccag catgaccttg atgatgtcgt
    15301 ctcttgcatc cttcatggtt cttccgtttc tttcagggga ttagtgcctt gaccgcccag
    15361 ccattgccgt atggcccata ggacagggtg ccgcccattt tcgcaaggcg ttgggagagt
    15421 cgttgcagtc cggttccacc tgtcggcttc ccgctttgac cggatgcctc gccggtggtg
    15481 ccgtgtccgg agacgtgtcc atcgttgcgg atcgtgattg ctgttccgcc atcacggtaa
    15541 tgattccagg agacggcaat gcgggtcagt cccgcgccgt gccgaagggc attggtcagt
    15601 gcctcgcgag tgacggcgaa gcataaatcc gaacggcggg gatcctcgac gcgtcttccc
    15661 gtttcggtga acacgacgat gattccggtt gagcgtatgt gttccagtac gggtctgata
    15721 tcgtcccaat cccgtaaacg aaggatgtca tcctgattca ctggttcaag accgacctgt
    15781 tccaaagatg gctgcgattc ctcttcattg aagaccttta agatgcggcg cgtatcaccc
    15841 agactgtcct tcgcaatcga tgtgatctcc gctaaggcat cggccagttg cgagtcggaa
    15901 tagccgccgt tccttatgca gtcctcacct ccctgcgata acgcgatgat cgaggtcaat
    15961 ccatgaccga cgctgtcatg cagttcgttg gccatgcgaa ggcgccgttc cgtacgattc
    16021 ttctcctccg ccagtattgc ggcctttcgc cgtgcctcgg acagtagcct attcgccgtt
    16081 cgacggtccc gcgctatgga caacagtgag gatgcgatgc cggccaaagc gacggaatac
    16141 agtaacgcca aatactgagg ctgcagagag gcgggatgca tgtattgcat tgcgatcatg
    16201 cagatcatgg ccagatcgca catggcctga gcatacaggg gaagccgaat gcacagataa
    16261 agcaccagga taagagcgac ctgcgtgtat gagtgcaggc caacgccgaa caggacgccc
    16321 agggagagct caatgaattc caaggccagc aacgccacgg ggcttctgaa ccttaacgtc
    16381 acgtttatgg ctcctaaaac cagcagtatg aggaagtacc atatccccgc tccctcgttg
    16441 aggaaccgga taaacgaata tcctgtgccg attgccatcc gctcttccac ataatcgcgg
    16501 atcagcacgc ccatcgtgcc gacgatgcag atcagagttg tcgtgaaacg aagcaggcgt
    16561 tcccctttga gctgacgaag ccatagaatc aatcgatccc gcggggtgac ggccagcgtt
    16621 tgtccctcat ctgatgactt accccggcgt gagcccataa tgaggcggtt cctcgcaacc
    16681 tgcaccttac gccttcttcg ttgtccgaga atacagctct cccattatct acgattcgag
    16741 gctcgcatgt ccatgacctg gctcctgttt gacatctacg gatgacagta gcttatcgcg
    16801 gacttcccgc tccgcttgcg gagagaatgc tccaggcggg gctgttcgac atactctccg
    16861 caatcggcgc gggaacgcgg ccccgggcca tgcgctacgc gcatgaccat gttgtctggc
    16921 cgcttgcatg ctcgcggcgg tgggccgcgc ggaatctgac gagggggttg cggccaccac
    16981 cagcatgcca tgcgctccgt ctgcgttccc tgcgccgtgt cccgcgccgc tcccgtgcct
    17041 gcgctgcgac ggcgaaccag catgccgtct tcgctacggc ccggatcgtc gcggtccacg
    17101 cctccggtct ctccgcctac gcgcatggca ggcgggtggt gtccgaaatg gaaaccacac
    17161 ggaaaggacc gatggacatg aacgacatgg tggacacccg cacgacggga accgggctgg
    17221 cgaagcgcgt acgcgacggg ttccttcagg accggcgtga acttggaccg gcgcaagcgg
    17281 ccgacaagtg gttcgcgccc ctgatggaca ggtggaacgg cctgctgtcg cgcgacgagg
    17341 gcggcttctc ccatgaggag cgcgtcacgc tggcggtgct gatgaccgag tacctgagca
    17401 tgcgggacgc gctgatactc gcatcgctgc acgaaatggg cggcggcgaa ctgcacatgc
    17461 tgtacgccaa gccgcattcg atggaatcgg cggccgtggt catgcgcgaa ctgtcacggg
    17521 cgttcaagga cgccgactac cagccggaca cgcgacgcgg ggaacgcgcg acggcgttgc
    17581 tggaatcggt gacggccgac gccccggacg gatacgaggc acagccgatg gcgtcgtgcg
    17641 cgtacctgct gtggatggcc gaccgttcga ccgccgccgc ggtgcgcgcg ctcaaggcct
    17701 tggccttgga cgacgactgt tcgctggcgt ccctcgtgct cgcggccagc gaacacggca
    17761 tccgccccgc atggacggaa cgccgccgcc actgagcgtc ggccgcggat tcaatccggt
    17821 cggggcttcc gacgccggaa gccccgacca atcccaatca tccgattttt tcaaggagac
    17881 aaacatggaa accgcaatca tcgaacgtcc cgtaatggcc gacgaaggca tggacgaatc
    17941 gaacatcgtc atgctggatg tggggcttat cgacccgaac cccgcgaacc cgcgccgtga
    18001 cgtgggcgac gtgtcggaac tcgcggattc gatacgcgcg cagggcatcc ggcagaactt
    18061 gctcgtcact cccacgttgc agggacgcta cctgctcgtc atcgggcatc gtcgcctcgc
    18121 cgccgccaaa ctcgccggat tgagccgggt gcccgccgtg gtggccgatt tgtcggaacg
    18181 ggagcaacgc gaactcatgc tcgtggagaa cagccagcgc gccgacctga ccgtcatcga
    18241 agaggccgac ggctatcagg ggcttctcga tttgggcgtg ggcgtggatg aggcggcgca
    18301 acgcaccggc cgttccgtgt cattggtgcg ccgacgcctg aagatagccg ccatcggcga
    18361 gaacgctcga agcaaggccg gaaccgccca gctgagcatc gacgactggg agaccatagc
    18421 cgacttcgac cggtatccag accttcagga acggctcgcc gaggcggcgg gcggcaagaa
    18481 ctggaacatg gccgtcaagc acgcccggca ggagcggaca tggcgcgaat ggctcgacac
    18541 ggcgcgagcc gaattggaac gcatgggcat cgacgcggcc gacgaacagc cgaacacgga
    18601 caactggtat gactcgccga agggattgcg gcgcaccacg atgctgacca cgggcgacat
    18661 cgccaaggcc atcgacgcat ggcgcgactc ccatgacggt gccacgcccg tcgtgggggt
    18721 gcgggccgaa ggcgcgtcat gggcgcgcgg catcgtcctg tacgagaccg tggacgagga
    18781 ggcggagacc gcggcccgcg aggcgcggga ggcgcgttgg cgagaggaac gggaacgcga
    18841 ggaacgcgag acggcaccgg ccaaggagtt cgcgcgggca agccgtgatt tgcgcatcgc
    18901 gttcgtgacg catctcatgg aactgaaatc ccagccgaaa ggcatcggca gggccgtcgc
    18961 cctgctgtcc gcgagattcg cgctcgatgc gctcaccgag ggattcgacc aatgggacgg
    19021 tcacgccgag gacgtctggg agcaaatcac cggcatcgac acgacgggcg acgacgccga
    19081 tgccgaggaa ccggagggcg agaccgaaga cccgttacgc gcgtccgtca ccgcgatgat
    19141 tgccggcgac ccgcaacggg ccgcgttcgg actgctctac gcgttggccg aggaacgcgt
    19201 cagctgggaa acgtggcgcg gcgcggcgac catcgcggaa cacgccgcac cgctgtacga
    19261 ggctttggaa acgctcggtt accgcacctc ggacacggag accgaagccc tcaacggctc
    19321 cctcgcgcca atcgatgaca acgacaatgg cggggatgcc ggcataaggc aggacggcga
    19381 accggacgac gacgggacgt cgcagaccga cgacgcatcc ggcaagccgg aagacgccga
    19441 ataggcgacg aactgggcgg aaccggaata agggttccgc ccagtccggg cgcggacggc
    19501 gaaacgtgac ggcgcatgcg cgcccgcacc tgccggagcc aagcggcggc aggtgacgct
    19561 cagccgtggc gggcggagcg tcgtcggagc cgcgcgtcgc accaatccat gagcatgctc
    19621 gcaagcacgg ccgtgaggaa cgcggcgacg atcaacgcga acgagccatc caatgccgga
    19681 gcgtccgaac cggcgaggaa atgcatgagc aggaacgcca gcatgagcaa tcccgacagc
    19741 atggcgaacg ccgtgaacac ggagttcgca aggaacacca cgagccgcaa cgggtgcgcg
    19801 agcagggcaa ggcacgaggc cacgccccgc atcagcatgc gtatcacgcc cgtcgccagc
    19861 gacaggccaa gcatcaccag cagcatcggc atcgccgtca cctcccgtat gtcgccaatg
    19921 tcatccagcg tagccgccag gacgcgggaa accgaatcgc aacccctccg ggtccaatcc
    19981 aatcgaaccg gacgtgccag catccacggc atcagccgca ttctccgttg cggcgttgtc
    20041 ctccgtcagg gcagtctccg gcgcatcggc ggcggatgcc ggtcggccgc cggattcgac
    20101 ggccgaatcc tcgccatcat ggatttcgcc gtggctatcg gcgggattgg cctgcccgta
    20161 gtcgggagtg acggcatgga acgccatgcc cgtctccctc ggctccattc tgagcgtgcg
    20221 cacaagctgg gcgcgcggca tgtgatggtc gtcgcagaac gactgggcgg cgtcgcggaa
    20281 tcgttccgcg gcccagcgca tgtcgtccag caggatgccc aaacgcgaca gttcgccgcg
    20341 tttgcgccga agcgcctcca actcggcatc caatgcgttg tctgcgatgg cgcgcatcgc
    20401 ccggttgcgt tccctcggct tcgccatgac ggtctcctca cggtgattgt tcttcgttgc
    20461 cccgcatcgt agaatgacgc cggccatgat gccggcggac acgaaacgga accggcgccg
    20521 gcatgcgaaa cgtgacatgg agtccgccgc gcatggcgtg gcgcgaaggt gaaactgacc
    20581 ggtgcgcaac catcccctcc ccggaggggc ggttggtgtg cagcaagcat cgcccgtgta
    20641 cgtacaccgg cgcggccccg cgaggctcgg ggccgattac gggacacccg tggaacccga
    20701 tacgaggagg caccgatggg ctggaaaggc aaccgttcca gaacgatccg caaggcggtc
    20761 acgttcagcg aggaggaatg gcggtgggtg gcggactcgc tcaaagtgga gaaccgtcag
    20821 cgcatccagg ccgggctcag gccagtggga tggatgacgt tcgcccgcaa ccggatcaga
    20881 tgcgcccacc gcgtcaacat caccgtgccc gcgaacctgc atgacgtgag cgcccaacta
    20941 gcgaggatcg gcaacaacgt caaccagatc gcccgtcacg cgaacaccac gcgggagacg
    21001 gacctggcca tgctctcgcg cgtgttcgac gagctgcgcc aggcggaacg gctggtcgcg
    21061 ggcctgagca tccgggtgga gaccgatgtt gaccccaagg gggtgcccga atggctgtag
    21121 tcaagattgg caagatcaaa agcacgctcg cccgcagcat cgcctacgtg acgaacccgg
    21181 ccaaaaccga cggctaccgg tgggcctcga ccaccgtcgg cgatgacatc acggacgccg
    21241 agtccatcgc ccgcggcttc gaacgtgcgt tggacgccac gaaaggtggc tcacgccggc
    21301 agggggccgt gttggcgctg cacgtgatcc aatcgttcga tcccaccgat caagtcacgc
    21361 cccgattggc gcatctgatc ggggaacggt tcgtccggga gatcaccgga ggcacgcacg
    21421 actacgtgat cgccacccac accgacaggt cccacatgca caaccacatc ctcatctgcc
    21481 cggcagaccg gatcacgggc aaggccctgc gtctgcggaa agggaccttg ggcgaatggc
    21541 ggaagatcag cgaccggctg tgccgcgaat acgggctgca caccctcatg ccggaacagt
    21601 ccgggcgcgt ggccccgtcg atcggggaac tccacctgag cgccagaggc ggcaacctca
    21661 aggaccggct gcgcaccagc atcgacacgg cctgcatgaa cgcccatgac ttcgcgggat
    21721 tccgccgcga actcgcgacg ctcggcgtc
//
