LOCUS       c00042_JAJGTF0..       12151 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJGTF010000162.1 Limosilactobacillus reuteri strain M_81
            scaffold162, whole genome shotgun sequence.
ACCESSION   JAJGTF010000162
VERSION     JAJGTF010000162
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 10:44:44
            Original ID  :: JAJGTF010000162.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 61948
            Orig. end    :: 74099
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12151
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[66948:69099](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7151
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12151
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12151
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             401..1795
                     /locus_tag="ctg42_57"
                     /transl_table=11
                     /translation="MQKLSIKQLIIITLGLLVLVMGLMTIHQRRHFNKNVKIDNVAVGG
                     LTAKQALKKLQDNPQTPKVYVNNDLVYTGKQPVAKFTQADEEKVANALHRQYTFFPSNK
                     DKNLLIKPQKFNQSVVPQVDQAVSQKVMELNNGRKAPINAYAVYENGQVQVRPAVGGTQ
                     YSLDGLHNQVEKELVQGEVKLKPIYKAPLSAKSKTVQNEKTKLEQIAKRDVTYQVQGKK
                     YHLTSADIITRATYQDGKYHFNTKVLGTKIDEINNQQATLGKPFEFKTHSGSVIKTTAA
                     GSYGWKISKKQAGKTLTNALIENKQTVNAKNDIYGKGYNQQGTGYNTTSNNGIGDTYAE
                     VSLADQHAWFYKNGKCVLSTDIVSGTNNKDNETPKGVWYIMYQQTPSVLRGLNDDGSKY
                     ASKVQYWSPFTDSGCGFHDASWRHDWSKQAYLAKGGGSHGCINMHPDVAGQAFSDLHKN
                     EPVVIY"
     CDS             1919..2083
                     /locus_tag="ctg42_58"
                     /transl_table=11
                     /translation="MVDLDLETKKNLVIINLFYIGLIALYCILHAGPLNFLVFLGMLVL
                     ANIAEFVVK"
     CDS             2238..3551
                     /locus_tag="ctg42_59"
                     /transl_table=11
                     /translation="MIHLTVGQGLTSSILNIIEIILIYQLVTSDFSLGLVIIDFLAVLM
                     IIFFSIVFFMLGSLYPVLIVFYFWLVDRIKSNSYIVINSILAMCISIVMASLFDLVDHY
                     TYTFFLQGKTDIALLGWLIPINDLIITIVVAILAVKVVRPKLRWIRINFPRPIGLWQIT
                     AILFMLYVWLTAIAEKDGVANKYASLLLIMYLIIIVVCATGFINFVKSSQQTQRQQQII
                     DKYQAQIASANQLNQQYNEIRRERHDTRNMLLSVQGYIRDHKDKEAEKLLATFLQNDTL
                     EKHYDEIDNALDKIKISGLHNLIKEKAYKIVEKGIPFSFEVNAEIDELPGSEIKTARII
                     GILMDNAIEATFKQAKPYIQFALLKHSPEVYELVIANSIEQKLNINTALKFEHSTKEGH
                     QGIGLSNVTQLVENDDHYSFSAEVKDKVIMMTCFIQGK"
     CDS             3559..4326
                     /locus_tag="ctg42_60"
                     /transl_table=11
                     /translation="MLKVIILENDDYQADYTERLVSQRKLINATPNSYDIELYLRTNDP
                     QEVIDSIKDEVYLAILDIELENQLSGIDVAEQIRKKAEFAEIIFITAYQEYLPYTVSHR
                     IEPFDYISKGEQIESIADRLRTDIDEAYARYQNYVSSNQKHHEKITYEPIRGVKRQVDL
                     ENLYYIESVKNTNRRLRIVGKDIRIEYHGELNQVDSNHLLKVNQSTLINPKAIQEFNRK
                     ERVVYFDANREIKVTVSYRKIKSLVDFLEKEDY"
     CDS             4567..4725
                     /locus_tag="ctg42_61"
                     /transl_table=11
                     /translation="MTYRKLNFDELSKVSGGWSLSSQVNELVKDVVNSLNKWAQSCYAG
                     YKDSPFH"
     CDS             5001..7151
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 330.7; E-value:
                     3e-100)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_62"
                     /sec_met_domain="TIGR01193 (E-value: 3e-274, bitscore:
                     903.9, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.2e-39, bitscore:
                     125.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKINYPHYVAQVDEADCGVAALAMILHNFGSVYPIAKLRDLARTT
                     KQGTTALGLLKAAKHLGLDVIPIQADLSLFDDPEITYPLIAHVIKDDLLHYCVVFKADQ
                     DYIYVADPDPATKVQKMTRDEFGRLWSGVSLLFSPAKGYTPQKEPLAGLMTMFRQLTNY
                     KKDISGIVIAALLITFISIVGSYYLQLIIDRFIPSKSINGLAILAGSLLVVYVFNSLFN
                     YLRDVLLTRLDQKLTSQISLRYIHHVYRLPMRFFSTRKTGEITSRFNDINKIIDALSST
                     IISMFLDVGVMVIIGHVLFLYDRSLFLTTISTIPIYVIIIYAFNKRFAKLDQEQMESNA
                     QLSSDIIEDLKGVETLKVLQLENIRYKNVEKQFADFLRKNLTYVKTKSFQDAIKMWIQY
                     GLVTIILFQGAVLVIQGRLSIGILMAFNALLAFFISPLQNIINLQPKLQEAKVANNRLN
                     EVLQVDTEKSDTNSQDQADLVGPINIQHVDYSYEYSRPILQDINLQIGCNDKLAIVGLS
                     GSGKSTLAKLLVGFYLPTQGQIEFNQHKTTKINLCDIRQYVHYLPQSPQLFSGTIKDNL
                     LMGLDHEVSAEEIDNACKLALIYNDIQEMPLKYETKLDEEATALSGGQKQRLTIARALL
                     TSAHVLIFDESTSSLDPITEKRIVENLLEIEDRTMIFIAHRLSIAKKVNKVVVMRDGKI
                     IEQGTHQELLNHHQEYYNLWNA"
     CDS             complement(7489..7674)
                     /locus_tag="ctg42_63"
                     /transl_table=11
                     /translation="MKIHFNKDFWRDGFFYIYLLLLFLWIAPFSDGSLPLDESLLCIFF
                     IIFTIGSMLAIMFNKD"
     CDS             complement(7952..8380)
                     /locus_tag="ctg42_64"
                     /transl_table=11
                     /translation="MSKYKVTATKTTTGMQVSAGTRGFEITFDEPESTNTGMNPVEILL
                     ASFGACQAITAQALAKKRNFDLQAFWVTIEGDLGREDVADGKNVRKFTEIRYQPHLRSN
                     ESDEDIKKFLADVAAKCPVENTLTYGTKFVQDGFVKVD"
     CDS             complement(8448..9443)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 298.6; E-value: 6.1e-91)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_65"
                     /transl_table=11
                     /translation="MTKILMTSVRDDEQTAINEYAKEHNIEIITTPKLIDDAVELTADV
                     DGLVIQQRSKVPADIYEKLHTNGLKQIATRTAGFDMVDIKKANENDLVVTNVPAYSPRS
                     VAEFALMQIFRLLRKTYRFDHQVAENDFRWFSDEQSTEIHTATIGIIGVGRIGGTLAKL
                     LHALGATVLGYDTNPRTDLDRIVQFVSKEELLKQADVVSLHVDLNPASKGLLTANDFAM
                     MKPTAGLVNASRGPVVNTADLVTALKAGEIAAAALDTFEGEETVAAADRREKGLDDQPL
                     VKELHEMDNVILTPHIAFFTNLAVKNMVDISLDDVMTILNGGKSPHEITL"
     CDS             complement(9445..10632)
                     /NRPS_PKS="Domain: Aminotran_1_2 (36-387). E-value:
                     1.8e-72. Score: 236.2. Matches aSDomain:
                     nrpspksdomains_ctg42_66_Aminotran_1_2.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 270.9; E-value: 3e-82)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_66"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.3e-07,
                     bitscore: 22.5, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTTKKEILNRLNNNFAKLTPGGIREFDYQVSAIPGIIKLTLGEP
                     DFNVPAAMKQAAIDSINANDSHYAPGNGTLALRQAIAHFMQDRYELEYDPENEIAVTVG
                     ATEGIFASLSTIINPGDEIIIPTPTFPFYMAVTKILGGIPIEVDTSSDDFVLTPARLQS
                     VLEEHPNAKGLVLNYPSNPTGVTYTQDQIKALADTVKSTNLIVIADEIYSELVYGATHT
                     SIANYIPEQTLILNGASKSHAMTGYRIGFIAGPQELMKSVSAIHAMLVTAASNPAMAAA
                     VAAFGTDEGKTATQEMKDAYEQRRDFVVNNLQKLGFELINPQGAFYVFAKIPEQYGNDD
                     LKFATDLANEGKIAVIPGSFFGAGGQGYVRISYATSMENLTGALDNIASFINKEN"
     aSDomain        complement(9472..10524)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg42_66_Aminotran_1_2.1"
                     /evalue="1.80E-72"
                     /label="ctg42_66_Aminotran_1_2.1"
                     /locus_tag="ctg42_66"
                     /protein_end="387"
                     /protein_start="36"
                     /score="236.2"
                     /tool="antismash"
                     /translation="IIKLTLGEPDFNVPAAMKQAAIDSINANDSHYAPGNGTLALRQAI
                     AHFMQDRYELEYDPENEIAVTVGATEGIFASLSTIINPGDEIIIPTPTFPFYMAVTKIL
                     GGIPIEVDTSSDDFVLTPARLQSVLEEHPNAKGLVLNYPSNPTGVTYTQDQIKALADTV
                     KSTNLIVIADEIYSELVYGATHTSIANYIPEQTLILNGASKSHAMTGYRIGFIAGPQEL
                     MKSVSAIHAMLVTAASNPAMAAAVAAFGTDEGKTATQEMKDAYEQRRDFVVNNLQKLGF
                     ELINPQGAFYVFAKIPEQYGNDDLKFATDLANEGKIAVIPGSFFGAGGQGYVRISYATS
                     MENLTGALDNI"
ORIGIN
        1 tatacggggc aacgggtcct aattcatttg attgctctgg attggttcaa tacgtttatc
       61 gtcaggcagg agttaactta ccacggacag ctgcccaaca atctaaccaa gggtacagcg
      121 tcagcatgaa taacttacaa ccaggggatc tcttattctg gggtaatcca ggaagtgcat
      181 accatgttgg aatttacact ggaaatggta agactttatt tgcaccacaa cctggtcaaa
      241 cagtaaaaga acaaccaatg agttactgga tgccaaactt tgctcgtcgt gttttgtaat
      301 aaaaatatta tttttttgtt taatatagaa aaccctactg ctataattat tagcgtgtag
      361 ggcatttcta ttatttaact tattaagttg gagtactttt atgcaaaaat tatctattaa
      421 acaactgata ataatcacat taggtttgct agtactggta atgggtttga tgacgattca
      481 tcagcgccgg cactttaata aaaatgtcaa aattgataat gtagcggtcg gtggtttaac
      541 ggctaagcaa gcactaaaaa aattgcaaga taacccgcaa acacccaaag tatacgtgaa
      601 caacgaccta gtttatacag gaaaacaacc agttgctaaa tttacccaag ctgatgaaga
      661 aaaggtggct aacgccttgc atcgtcaata tacctttttt ccatctaata aggataaaaa
      721 tttgctgatt aagccacaaa agtttaatca aagtgttgtt ccacaggttg atcaggccgt
      781 tagtcaaaag gtaatggaac taaataatgg gcgcaaagca ccaattaatg cttatgcggt
      841 atacgaaaat ggtcaagtac aggttagacc agcagttggc ggtactcagt acagtttaga
      901 tggtttgcat aatcaagtcg aaaaagaact tgtgcaggga gaggttaaac taaagccaat
      961 ttacaaggct ccgctttctg ccaagagtaa gacagtacaa aatgaaaaaa cgaagctaga
     1021 acagatagct aagcgggacg tgacctatca agtccaaggt aagaagtacc atttgaccag
     1081 tgcggatatc attactcgag ctacttatca agatggcaag tatcatttta ataccaaagt
     1141 attaggtaca aaaattgatg aaatcaataa tcagcaagct actttgggaa agccatttga
     1201 gttcaaaact cacagtggat cagtgattaa aacaacggct gctggttcat atggttggaa
     1261 gatcagtaag aaacaagctg gaaagactct tacgaatgca ttgattgaaa ataagcaaac
     1321 agtaaatgca aaaaatgata tttatggtaa gggttataat caacaaggaa ctgggtataa
     1381 taccacaagt aacaacggca taggggacac ttacgccgaa gtttcattag ccgaccaaca
     1441 tgcgtggttc tataagaatg gtaaatgtgt tcttagcact gacattgtta gtgggaccaa
     1501 taacaaagat aacgagacgc cgaagggtgt ctggtatatc atgtaccagc aaacaccgtc
     1561 tgttcttcgg ggccttaacg atgacggttc gaaatacgct agcaaagttc aatattggtc
     1621 accatttact gatagtggat gtggatttca tgatgcaagt tggcgtcacg attggtcaaa
     1681 acaggcttat cttgctaaag gcggtggatc gcacggttgt attaacatgc atccagatgt
     1741 agctggtcaa gcttttagtg acttacataa aaatgagcct gtggttatct actaaaggag
     1801 gagatgttgt gcgcccgagt gctgaacgcg caattatgat tgcaatagct tgctttgttt
     1861 taacaattat tatttctttt gcattatcag agggatggat aaagtaggag ttagttatat
     1921 ggtggatttg gatttagaaa cgaagaaaaa tttggtaatc attaaccttt tttatatcgg
     1981 attgattgcc ttgtattgta ttttgcatgc agggccactg aattttttag tgtttttggg
     2041 aatgttagtt ttggctaata ttgctgaatt tgtagttaaa taggtaattg ttatttattg
     2101 gaggtaatta tgttaaaaaa atcatataaa tttttatcaa ggaaagaatt atctaaagta
     2161 ttaggtggtt ggggatattc acttgccttt aaaagtcctc gttcatggga aagagcagtt
     2221 ttaaattgga ttaaaagatg attcatttaa ctgtaggaca aggattaacg tcatctatat
     2281 taaatattat tgaaataata ttaatatatc aattggtaac tagcgacttt tcattaggat
     2341 tagtaataat tgatttttta gcagtcttga tgattatatt tttttcaata gtatttttta
     2401 tgttaggatc gctataccca gtacttatag tattttattt ttggttagtt gacagaataa
     2461 aatctaattc ttatatagtt ataaatagta ttcttgcgat gtgtattagt attgtaatgg
     2521 catctttatt cgatttagta gatcactata cttatacgtt ttttttacaa ggaaagacag
     2581 atatagcact tttaggatgg cttattccaa ttaatgattt aatcataact attgtagttg
     2641 caatcttagc agttaaagta gttcgtccca aactgagatg gattaggatt aattttcctc
     2701 gaccgatagg gttatggcaa attacggcaa ttttgttcat gctttatgtg tggttaactg
     2761 ctattgccga aaaggacggg gtagcaaata agtatgcctc gctgttgtta ataatgtatt
     2821 tgataattat cgtagtgtgt gcaaccggat ttattaattt cgttaaaagt agtcagcaaa
     2881 cacaacgaca gcaacaaatc atcgataaat atcaagcgca aattgccagt gccaatcagc
     2941 tgaaccaaca atacaatgaa attcggcgtg aacgtcacga tacacgcaat atgcttctca
     3001 gtgttcaagg atatattcgt gatcacaaag ataaggaagc agaaaaattg ctagcaacgt
     3061 ttcttcaaaa tgatacactt gaaaagcatt atgatgaaat tgataatgct ttagataaga
     3121 ttaaaatttc agggttgcat aatcttatta aggaaaaggc ttataaaata gtcgaaaaag
     3181 gtattccatt ttcgtttgaa gttaatgctg agattgacga gttaccgggt tcagaaataa
     3241 aaactgctag aattattgga attttaatgg acaatgcaat tgaagcaacc ttcaaacaag
     3301 ccaaaccata tattcagttt gcattgctta agcacagtcc agaagtttat gaattggtaa
     3361 ttgctaattc gattgaacaa aaacttaata ttaatactgc actgaaattt gagcattcga
     3421 ccaaggaagg acatcaaggg attgggcttt caaatgtgac ccagttagta gaaaatgatg
     3481 accattattc tttttcagcg gaagttaaag ataaggtaat tatgatgact tgttttattc
     3541 agggaaagtg agaataaaat gttaaaagta attattttgg aaaatgatga ttatcaagct
     3601 gattatactg agcgtctagt ttctcagcga aaattgatta acgctactcc aaatagttat
     3661 gacatagaat tatatttgcg gacaaatgat ccgcaagaag tgattgatag catcaaagat
     3721 gaggtttatt tagcgatttt agacattgag ctagagaatc aacttagtgg gatcgatgtt
     3781 gctgagcaga tccgcaaaaa agctgaattt gcggaaatta tctttataac tgcatatcaa
     3841 gaatacttac cttatactgt ttcgcaccgg attgaaccat tcgactatat atcaaaggga
     3901 gagcagattg agtcgattgc ggatcggctc cgaacagata ttgatgaagc atatgctcgc
     3961 tatcagaatt atgtaagtag taaccaaaaa caccatgaaa aaattaccta tgaacctatt
     4021 cgtggtgtaa aacgacaagt tgatttggaa aatctttact atattgaatc agtaaaaaat
     4081 acaaatcgac ggttacggat tgttggaaag gatattcgaa ttgaatacca tggtgagcta
     4141 aatcaagtcg atagtaacca tctattgaaa gttaatcaga gtactctgat taatcctaaa
     4201 gcaatccaag aatttaatcg taaggaacgt gtagtttact ttgatgcgaa tcgagaaatt
     4261 aaagtgactg ttagttatcg aaaaataaaa tcattagttg attttctcga aaaggaagat
     4321 tactaactac tttattttta aagaaactgt gacaaaaagc tgtcgtggtt tcttttttat
     4381 tgtcaaataa tttcagtaaa cgttttcata acttttacta cgaattctgc agaaaggctt
     4441 acgaattttg caaaatgaca cagagaaaat ttatacttat atactaaggg tgggatcaag
     4501 gtaaagtatt atacattgga acataatgtt aaaatcctaa ctttatcgta tcaggaggca
     4561 attaaaatga cctatcgtaa attaaacttc gatgaattaa gcaaggtttc tggtggatgg
     4621 agtctatctt cacaggttaa tgaactagtt aaagatgttg ttaattcctt gaacaaatgg
     4681 gctcaatctt gctacgcagg ctataaagat agtccatttc actaatagtt tataacttaa
     4741 tgattatgaa atttaaccac gatttttaca ccaatcttga tttttatatc tatattatag
     4801 ttacattctt ctgggtctta gcaattccca aagcaggtaa catttatgaa acaattatat
     4861 gtatagcttg cacaatcatt ggtatttttg cggctctacg aattttattt aaaaataaat
     4921 agtatcttat aagaatatga agcccagaat cattattaat tttggacttt atttctttgt
     4981 ctaattagaa agcaaggtga atgaaaatca attatcctca ttatgtagct caagttgatg
     5041 aagcagattg tggagtcgcc gcgttagcaa tgattttgca caattttggg tctgtttacc
     5101 caatcgcaaa attacgtgat ctagcccgaa caactaagca aggaactact gccttaggat
     5161 tattaaaagc agcaaagcat cttggattag acgttattcc cattcaagca gatctatcat
     5221 tgtttgatga tcctgaaatt acttacccat tgattgcgca tgtgattaag gatgatttac
     5281 ttcattactg tgtcgttttt aaggctgatc aagattacat ctatgtagct gatccagatc
     5341 ctgctacgaa agtacaaaaa atgactcggg atgaatttgg tcgtttatgg tcaggtgtaa
     5401 gtttactttt ttcgcctgct aagggatata cgccacaaaa agaaccttta gctggattaa
     5461 tgacgatgtt tcgacaatta actaattata aaaaagatat atcaggaatt gtcattgcgg
     5521 cattattaat taccttcatc agcatcgtcg gttcatacta tctccaatta attattgatc
     5581 ggtttattcc ctcgaaaagt attaatggct tagcgattct tgctggtagt ttattagtag
     5641 tttatgtgtt taattctctt tttaattatc tgcgagatgt tctcttgact aggctggatc
     5701 aaaaactaac gtcacaaata agtcttagat atattcacca tgtttatcgt ttaccgatga
     5761 gatttttctc cacaagaaaa acgggggaaa taacttcgcg gtttaatgac attaataaga
     5821 ttattgatgc tttatcaagc actattattt caatgttctt agatgttggc gtgatggtga
     5881 ttattggcca tgttctcttc ttgtatgatc ggtcattatt tttaactaca attagtacca
     5941 ttccgattta tgtcattatc atttatgcct ttaataagcg ctttgctaaa cttgatcagg
     6001 aacagatgga aagtaatgct caattaagtt ctgacattat tgaggattta aaaggcgtag
     6061 agacattgaa agtgctgcaa cttgaaaata tccgttataa aaatgttgaa aaacaatttg
     6121 cggatttctt acgaaagaat ctaacatatg tcaaaactaa atcttttcag gatgcgatta
     6181 aaatgtggat tcaatacggt ttagtaacaa tcattctttt tcaaggagca gttttagtaa
     6241 ttcagggtcg cttaagtatt ggaatattga tggcctttaa tgcattattg gcctttttta
     6301 tcagtccatt acaaaatatt attaatcttc aacctaaact ccaagaagct aaagtagcga
     6361 ataatcgatt aaatgaagtg ctgcaagttg acactgaaaa gtctgataca aattctcagg
     6421 atcaagcaga tttggtaggt ccgataaaca ttcaacatgt tgattattca tatgaatata
     6481 gtcgcccaat tttacaagat atcaatcttc aaattggttg taatgacaaa ttggcaattg
     6541 tagggttgag cggttctggt aaatcgacct tggcaaagtt gttagttggt ttttatttac
     6601 ccactcaagg gcagatagaa tttaatcagc ataaaacaac aaagattaat ctttgcgata
     6661 ttagacaata tgtacattac ttacctcaat cgccacaatt attttcggga acaatcaaag
     6721 ataacttgct aatgggacta gaccatgaag tatccgctga agaaatcgat aatgcatgta
     6781 aattggcatt aatctataat gatattcaag agatgccttt aaaatatgaa acaaaactag
     6841 atgaagaagc aactgcatta tctggtggtc aaaaacaacg cttaacgatt gcacgagcac
     6901 tcctaacttc tgcgcatgtt ttaattttcg atgaatcaac aagtagctta gatccaatta
     6961 ctgaaaaaag aatcgttgag aatttgcttg aaattgaaga ccgcacaatg atttttattg
     7021 cccaccgtct ttcgattgct aagaaagtca ataaagtggt agtaatgcgc gacggaaaaa
     7081 tcattgaaca gggtactcac caggaacttt tgaatcatca tcaagaatac tataatttgt
     7141 ggaatgcata aaagaggctg ggagaaaact tttgttttct ctcagcccca actacttgtt
     7201 atgaacaata gaaagataac gtggaaaata accacaaggc tcgagtctaa gtacgaacga
     7261 taatcagccc gtgccgtgct aatcatcgtc ctagcttagc caaccgcctt gtcgagnnnn
     7321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnaacg tggaaaataa
     7381 ccacaaggct cgagtctaag tacgaacgat aatcagcccg tgccgtgcta atcatcgtcc
     7441 tagcttagcc aaccgccttg tcgaggaggt tatttcccac tctctttttc agtctttatt
     7501 aaacataatt gcgagcatcg aaccgatagt aaaaattata aagaagatac atagtagtga
     7561 ctcatctaat ggcagcgaac catctgaaaa tggtgcaatc cagagaaaca aaagtaataa
     7621 gtatatataa aagaaaccat cccgccaaaa gtccttattg aaatgaattt tcattagttc
     7681 tccccctaag acagtatgtg taccttatta taatgaaaga tctaatttaa aggacacttt
     7741 gcaaaattcg ttaagtttct tgcagaattc gtataggtta actatttaga aagggactgt
     7801 gacataagcg aagttacttt cataaaaaac aaatggcgca gtacaccaat ggcctccaac
     7861 gcccggtaaa accgaatgtt ggaggcctat tgttgcttgc gggggctcga aaacgaagtc
     7921 acgagtgact tctgtctcgc tcccttttca actaatcaac ttttacaaat ccatcttgaa
     7981 caaatttcgt tccgtaggtc agagtgtttt ccacgggaca ctttgcggca acgtcagcga
     8041 gaaacttctt aatgtcttca tcagactcgt tgctgcgtag gtgtggttgg taacggatct
     8101 cagtaaactt acgaacattc ttgccatcag caacgtcttc acgaccaaga tcaccctcga
     8161 ttgttaccca aaaagcttgt aaatcaaagt tacgcttttt agctaatgct tgggcagtga
     8221 ttgcctggca ggcaccaaat gatgcaagga gaatttctac tggattcatc cccgtattag
     8281 tactttctgg ttcatcaaag gtaatttcaa aaccacgggt acctgctgaa acttgcatcc
     8341 ccgttgttgt cttagttgct gttactttat atttactcat aaccgtgccc tcctttaata
     8401 cccatagtgt aatcgagacg atacttttgg tcaatgaggg tgctcaatta taaggtgatt
     8461 tcatgtggtg attttcctcc attaaggatt gtcatcacat catcaagtga aatatccacc
     8521 atatttttga ctgctaaatt agtaaagaag gcaatgtggg gagtaagaat gacattatcc
     8581 atttcgtgta attctttaac aaggggctga tcatcaagtc ctttttctcg gcggtccgca
     8641 gctgcaactg tttcttcacc ttcaaaggta tcaagggcgg ccgcggcgat ttcaccagct
     8701 tttaatgctg tgacgaggtc agctgtatta acgactggac cacgactagc attgaccaaa
     8761 ccagcagttg gtttcatcat tgcaaagtcg ttagcagtca acaatccttt ggaagctggg
     8821 tttaaatcga cgtggagact aacaacatcg gcttgcttta gtaattcttc tttagaaacg
     8881 aactggacaa ttctatcgag gtcagtgcgc ggattcgtgt catatcctag aacggtagca
     8941 cctaatgcat gaagaagttt tgccagggtt ccgccaatgc gtccaacacc aataatccca
     9001 atcgtggcag tatgaatttc cgttgattgt tcgtcgctaa accagcggaa gtcattttcg
     9061 gcgacttggt ggtcaaagcg gtaagttttc cgaagcaacc ggaaaatctg cattaatgca
     9121 aactcggcga cactccgcgg cgaatatgct ggtacattgg tcacgactag gtcattttcg
     9181 ttagcctttt tgatgtcgac catgtcaaat ccagctgtcc gcgttgcaat ttgtttgagc
     9241 ccattggtat ggagcttttc ataaatatcg gctggaactt tactgcgttg ctgaattacg
     9301 agtccatcaa catcggcagt taattcaaca gcatcgtcaa tcaatttcgg cgttgtgatg
     9361 atttcgatat tgtgttcttt tgcgtattcg ttaatggcgg tttgttcatc gtcccgcaca
     9421 ctagtcatca agatttttgt catgttaatt ctccttatta atgaaggatg caatgttatc
     9481 aagagctccg gttaaatttt ccatactggt ggcgtaacta attcgaacat atccttggcc
     9541 cccagctcca aagaaggaac caggaatcac agcaattttt ccttcattag caagatccgt
     9601 cgcaaattta aggtcatcat taccatattg ttcaggaatc ttggcaaaaa cgtagaaggc
     9661 tccttgagga ttaatcagct cgaaccctaa tttttggagg ttattaacaa caaagtctcg
     9721 tcgttgctca taggcatctt tcatttcttg agtagctgtt tttccttcgt cagtaccaaa
     9781 tgcagctact gcagcggcca ttgctggatt agaagcagca gttactaaca ttgcgtgaat
     9841 agcactgact gatttcatca attcttgcgg cccagcgata aaaccaatgc ggtaaccagt
     9901 cattgcatgt gattttgagg caccatttaa aattagcgtt tgttcgggga tgtaattagc
     9961 gattgaagta tgagtagccc cgtaaacaag ttcagagtaa atctcatcgg caattacaat
    10021 caggttagtt gatttaactg tatcggctag tgctttaatt tgatcttggg tgtaagtaac
    10081 accagttggg ttggaggggt agttaagaac tagtcccttt gcgttaggat gttcttctag
    10141 tacgctctgg agtcttgcgg gtgtgagaac aaaatcatcg ctgcttgtat caacttcgat
    10201 cggaatccca cccagaatct ttgtgacagc catgtagaag gggaaagttg gagttggaat
    10261 gataatttcg tcgccaggat taataatagt agaaagagaa gcgaaaattc cctctgttgc
    10321 accaactgta acagcaattt cgttttccgg atcgtattcc agctcgtaac gatcttgcat
    10381 gaagtgagcg attgcttggc gtagtgctaa ggtcccattt cccggagcat agtgtgaatc
    10441 attggcattg atgctatcga ttgcggcctg cttcattgcg gctggcacat taaagtctgg
    10501 ttcacctaat gttagtttaa tgatgccagg gattgcgctg acttggtagt caaattcgcg
    10561 gatcccgcca ggagtgagtt tagcgaaatt attgttaaga cgattgagaa tttctttttt
    10621 agtagttggc atgataaatc cctcctatat aatatgtaga tttagaaata aaagaagccc
    10681 tgaatgctat aggaaaaaca tccagggctt cttgatcaga ttggaatgag tataaaagag
    10741 gctctcggat gtttgggggt catccgggaa catcacaatg ataaaatcac tgctggttag
    10801 cggacggtaa tcacgctaaa ccagaagaca tacgcttgat tcaagtgaat tgtcgcagtg
    10861 ctcatcattg tgtcctcctt ttgattaact gattattaat tattctaatt attttttaat
    10921 ttttgtcaag agttgattga gaaaaattat taattacaaa attatttatt gatgacaaat
    10981 gtaaatataa taaagtgtga aaatgtttgt gattattatt tcgcctttaa tttaatatta
    11041 gatttatatt ctacaatttt ttttattttt ttcgcgtctt ttttgttgtc ttactccaca
    11101 aatgtgatat aatattaatt gtaaaggaag tgggtagcaa tgcggatcga catcaaacat
    11161 tatttggaag ttaaccactt gaccatttat caagtttcca agcgttccgg ttacggctac
    11221 acgactttac acaaatcgtt taacaaacca cagtctagtt cgacctcgct taacctgcgt
    11281 gatcttgatg ccttggctcg tgctcaggac aagagcatgt ggaaggtcct taaagaacta
    11341 gaagagcatt acctcgaatg agattgtggc tttgctgtag ccacaggaag ttaaatgcgt
    11401 taacttttga cttctagaat acttagacta cgaaacttag aaaacaaaat attatattta
    11461 attgaggagg gattgcatat ggctcaaaac ccaatgaatc catttgacaa cgacatgaat
    11521 gacatcttta atcaattaat gggtggcatg aatggtttca attctgataa tcggcgttac
    11581 ctaatcaatg gtcgtgaagt aacaccagaa gaatttgctg aatatcgtag aactggtcaa
    11641 ttgccaggcg gtgcaaatcc tcaacaaggt gggcaacctg gccctcaacc taacgcaggt
    11701 aaggacagta tcttacacaa gttaggtcga aacttaactc aagaagctcg tgaacatgaa
    11761 cttgaccctg ttattggtcg gaacaaggaa atccaagaaa cagctgaaat tttaagccgg
    11821 cggacaaaga acaaccctgt attagttggg gacgctggtg ttggtaagac tgctgttgtt
    11881 gaaggattag cacaagcaat tgtttccggc gatgtaccag ctgctatcaa ggacaaggaa
    11941 attatcagta tcgatatttc tggccttgaa gcaggtactc aataccgtgg tagctttgaa
    12001 gaaaacatgc aaaagttggt tgatgaagtc aagaaggctg gaaatatcat cctcttcttc
    12061 gatgaaattc accaaattat cggtgccggt tcaactggtg attctagtgg ttccaagggt
    12121 atgtctgaca ttattaagcc agcattatcc c
//
