LOCUS       c00027_JAJGTL0..       15365 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJGTL010000049.1 Limosilactobacillus reuteri strain R.n.3-A
            scaffold49, whole genome shotgun sequence.
ACCESSION   JAJGTL010000049
VERSION     JAJGTL010000049
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 18:02:54
            Original ID  :: JAJGTL010000049.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15365
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15365
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5411:11879]"
                     /cutoff="10000"
                     /detection_rule="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /neighbourhood="10000"
                     /product="Nitrate_reductase"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5412..11879
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /neighbourhood="10000"
                     /product="Nitrate_reductase"
                     /protocluster_number="1"
     cand_cluster    1..15365
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /kind="single"
                     /product="Nitrate_reductase"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15365
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Nitrate_reductase"
                     /region_number="1"
                     /rules="(Nitr_red_bet_C and Nitrate_red_del and
                     Nitrate_red_gam and Molybdopterin and minimum(2, [Fer4_11,
                     Molybdopterin, Molydop_binding, Nitr_red_alph_N]))"
                     /tool="gutsmash"
     CDS             complement(98..1048)
                     /locus_tag="ctg27_1"
                     /transl_table=11
                     /translation="VLETANWIQKYFNQSPDAIFLFKNDDLLVSNEPAQRLVTMLNLDV
                     NYLLQIGKNAWSQLENDDCASCLIKKRLKEAAVPITFHSNATHPFHFSMVYRPLDDKEN
                     VFALTLENREQQQRLSQVEEHRILNQYVNEAHEKERQKISQDLHDSVAQGIYAAIMGIQ
                     RLATVQNQRNTEQFQSMSAAIEKQLQTTLKEIKGLALDIRPSVLDNFGLIPAIKALAKR
                     LQNSTGITIDVIALTSAEKLQKNIQNVLYRITQEAINNAIKHAHSTEISIIVTDHSSYL
                     QLEILDNGIGFDIDQHSGFNGHSLGLMNMNRVGDN"
     CDS             complement(1199..1483)
                     /locus_tag="ctg27_2"
                     /transl_table=11
                     /translation="MKSKDSMTNPDFQKLISLVLNDLTIRRTMLENREQEVSQQMSSLE
                     KDAELEQLDDQIQQIQADFDHYREFQDPEFDFSATKYFQGPSMGLPRHP"
     CDS             complement(1473..2045)
                     /locus_tag="ctg27_3"
                     /transl_table=11
                     /translation="MIGLVYAGGKSTRFGKDKATYHVPGLPATNIELAVEKLTPLCQQI
                     VVCANEINRAHILKLVGQEPAVQIICDIPPYDHHGPLSAIIACTNQFSIVQDYLTLAVD
                     YPYITKNSLAVLARTPNSYIATSQHNHYSLAHFSVSNEQVTTWVDNNDDWRLRSFITNK
                     CVCHPLTYRSSNEFSNLNYREVDLNEK"
     CDS             complement(2042..2533)
                     /locus_tag="ctg27_4"
                     /transl_table=11
                     /translation="MAITLQIIGHKKSGKTLITTTLIERLSKEGYRVAALKHDAHNAAM
                     DVPTTDSARMSSAGAKQVILQSATEFFFHQKSNVPSLTEMVELLSTDNDFILIEGHKEA
                     TQYPQILLLKPGEDSTNVAHTPPLKTGSIFNGTTADLLGKDAIVNWCYDYLKQVKGDAE
                     "
     CDS             complement(2512..3105)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MoCF_biosynth"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MoeA_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_5"
                     /sec_met_domain="MoCF_biosynth (E-value: 4e-17, bitscore:
                     52.3, seeds: 114, tool: rule-based-clusters)"
                     /sec_met_domain="MoeA_C (E-value: 4.4e-14, bitscore: 42.7,
                     seeds: 41, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKNLVEETGGIVDFETQLPDDADLIKQTLEEQIATHEIVITDGG
                     VSVGDFDFIGDEARKADELLFNKIKQRPGSVTTAFVQNSTLIMALSGNPGACFTGFYLY
                     MEPLIRRYQHQVSRIKQVRAILTAPYNKTNGFDRYLRCTYKFKDNQFYVYPNGINRSGS
                     LANLQTTTCLALIPHSTTPMKVGTETDAWLLPFK"
     CDS             complement(3297..3764)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MoeA_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_6"
                     /sec_met_domain="MoeA_N (E-value: 1.3e-32, bitscore: 102.8,
                     seeds: 1302, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTRRIPISVAEAQKKINEISLKTATETIPLSEANHRVLAKDVHA
                     HYDYPHFRRAGMDGYAILASDDHDFPREFNVRGEIQAGATWDQPLQSGDAVRIMTGAYV
                     PSDVGKVIRIEKTRPAKDENKVQIITTESKTNITEAGTDVTRLTLRKLVLM"
     CDS             complement(3754..4251)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MoCF_biosynth"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_7"
                     /sec_met_domain="MoCF_biosynth (E-value: 6.1e-34, bitscore:
                     106.9, seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIAILTVSDSRTLDSDTSGKLIAMKMANAGLSVVDRVIVNDDI
                     VNIQTAYLQLEQQALDIIITNGGTGIAQRDVTIPAIRPLLKRLIPGFGEAFRQISFEEI
                     GTRALASQALAGFNFRNQLTYCLPGSQNACQTAINKLILPEYEHLLFESSSQRKEVHHH
                     AH"
     CDS             complement(4248..5267)
                     /locus_tag="ctg27_8"
                     /transl_table=11
                     /translation="MNRYDRQERVHQIGSIGQQKISHATIMIVGVGALGSYTAEQLVRA
                     GVKRLVLIDPDTVDVTNLQRQSLFTEEDASKQRLKVEAAKEHLHKINSACQITAIPAPI
                     TADLIDEYQFTLCLDCLDNYQARDLLNKLAIIKNFDYLFASCAGTYGNVMAISPQNHPC
                     LNCLFPNINELKQNDCDLIGVNTALIPIVAGLQVSLALHYLVDKTQVNFNELITVDNWS
                     MQFSKFAINKNHHCPACAKPSSISLEEESGPELHMLCGENAYYTVKEKPINFGRLKEFL
                     AKKELLINANRLFLHFKWENRPVSIFKNGKIVMYDLPTSAIAQKQFKSLNILMKEDLL"
     CDS             5412..9077
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitr_red_alph_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Molybdopterin"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Molydop_binding"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_9"
                     /sec_met_domain="Molybdopterin (E-value: 5.4e-142,
                     bitscore: 463.7, seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Molydop_binding (E-value: 1.2e-23,
                     bitscore: 73.4, seeds: 74, tool: rule-based-clusters)"
                     /sec_met_domain="Nitr_red_alph_N (E-value: 1.1e-08,
                     bitscore: 25.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSRFFNKVDKFNGTFTQLEENSRRWEKLYRQRWAHDKVVRTTHG
                     VNCTGSCSWNVYVKQGIITWEHQATDYPSCGPNIPGYEPRGCPRGASFSWYEYSPVRIK
                     YPYIRGKLWELWTAAKEEHENPLDAWASIVEDPEKSKKYKKVRGHGGLIRVHRYEALEM
                     ISAACLYTIKKYGPDRIGGFTPIPAMSMMSFSAGARFIALMGGEQMSFYDWYADLPPAS
                     PQVWGEQTDVPESAEWYNSSYIIMWGSNVPLTRTPDAHFMTEVRYKGTKIVAVSPDYAE
                     NVKFADDWLAPEPGSDSAVAQAMTYVILDEFYQKHPVKRFIDYSKRFTDLPFMVELEPS
                     TANGDHYTPGRFVRISDLVDDDTIVNPAWKTVVYDQNNHKIVVPNGTMGQEYNAKEKWN
                     LELLDQNGNKIDPALSINDQDGETEQIVADFPAFSNDGNSVVQRHLPVKKLKFTDGKEH
                     LVTNVYDLMMAQMGINRTGNDELAAKDAMDAKSYFTPAWQESRSGVKAEQVIQIAREFA
                     QNAAENEGRSMVIMGGGVNHWFNADMNYRNIINMLMLCGCVGMTGGGWAHYVGQEKLRP
                     QEGWANITFANDWEKGGARQMQGTTWYYFATDQWRYEEIDNQAQKSPVWKSKHSYLHNA
                     DYNQMAIRLGWLPSYPQFDRNPLSFAKDYNTTDINEISKKVVDELKKGSLHFAAEDPDA
                     NQNQPKAFFLWRSNLFASSGKGAEYFMKHLLGAENGLLAKPNDRVKPQDMIWRDKGAIG
                     KLDLVVDMDFRMVSTPMYSDVVLPAATWYEKKDLSSTDMHPFIHPFNAAVSPMWESKSD
                     WQQFKLLAKTVSEMAKKYMPGTFYDLKSAPLGHNTQGEIAQPYGEIKDWKNGETEPIPG
                     KTMPSLKLVTRDYTKIYDKYITLGPNIVNNYNYKVDDQYDYLKDMNGIASEGIGAGCPL
                     LDEDEKVCDAILRMSTASNGKLADRAWEKKQERTGEHLTDIGRGHADDSMSFKQITAQP
                     QEAYPTPIGTSAKHGGARYTPFSLMTERNVPTFTLTGRQHYYLDHEIFREFGENMATYK
                     PSLPPVVMAPGDVDVPPVKDEVTLKYMTPHGKWNIHTMYYDNLEMLTLFRGGPTIWISP
                     QDADKIKVKDNDWIEVYNRNGVVTARAVVSVRMPEGSMYMYHAQDNEIYEPLSTITGNR
                     GGSHNAPTQIHVKPTHMVGGYGQLSYGWNYYGPTGNQRDLYANVRKLKKVNWSED"
     CDS             9067..10626
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Fer4_11"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitr_red_bet_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_10"
                     /sec_met_domain="Fer4_11 (E-value: 3.3e-39, bitscore:
                     123.3, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00052, bitscore: 10.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="Nitr_red_bet_C (E-value: 4.1e-28,
                     bitscore: 87.1, seeds: 110, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKIKAQISMVLNLDKCIGCHTCSVTCKNTWTNRPGAEYMWFNNVE
                     TKPGVGYPKRWEDEDQYHGGWTLNSKGKLKLRAGSKLNKIALGKIFYNNDMPELDNYYE
                     PWTYDYKTLFGPEQKHQPVSRPKSQITGEGMELTTGPNWDDDLAGSTEYVQQDPNMQKI
                     EGDIKNNFEQAFMMYLPRLCEHCLNAPCVASCPSGAMYKRDEDGIVLVDQERCRGWRFC
                     MTGCPYKKVYFNWKTHKAEKCTFCYPRIEEGQPTVCAETCVGRIRYIGAILYDADRVEE
                     AASTPDESKLYEAQLGLFLDPNDPEVVKQALKDGISEEMIEAAQKSPIYKMAVKEKIAF
                     PLHPEYRTMPMVWYIPPLSPVMSYFEGRDSIKNPEMILPGIDQMRVPVQYLASLLTAGN
                     VPVIKKALYKLAMMRLYMRAKTSGRDFDSSKLERVDLTEERATSLYRLLAIAKYEDRFV
                     IPSSQKAEMEDAQTEQGSLGYDECEGCALAPQHKSMFKKAEAGKSTNQIYADSFYGGIW
                     RD"
     CDS             10619..11197
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitrate_red_del"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_11"
                     /sec_met_domain="Nitrate_red_del (E-value: 1.6e-09,
                     bitscore: 28.0, seeds: 108, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIDFRRLTDLKDTFAVLSRLIDYPDTETFSPEIRQLLLADNALST
                     ATRGELLSLFDELAALSSIEVQEMYAHLFEMNRRYTLYMSYYKMTDSRERGTILARLKM
                     LYEMFGISEATSELSDYLPLLLEFLAYGDYTNDPRRQDIQLALSVIEDGTYTLLKNAVT
                     DSDSPYIQLIRLTRSLIGSCIKMEVQEDA"
     CDS             11190..11879
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Nitrate_reductase: Nitrate_red_gam"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_12"
                     /sec_met_domain="Nitrate_red_gam (E-value: 1.2e-77,
                     bitscore: 250.4, seeds: 140, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHNGWSIFLWVIYPYIMLASFFIGTFVRFKYFHPSITAKSSELFE
                     KKWLMIGSVTFHIGIILAFFGHCLGMFIPASWTAYFGITEHMYHIFGSLMMGIPAGILA
                     FVGIAILTYRRMTCSRVYKTSDINDIIVDWALLITIALGLACTITGAFIDYNYRTTISP
                     WARSLFVLNPQWQLMRSVPLIYKIHVLCGLAIFGYFPYTRLVHALTLPWQYIFRRFIVY
                     RRRARVY"
     CDS             complement(11950..12840)
                     /locus_tag="ctg27_13"
                     /transl_table=11
                     /translation="MNIKSVPKKQLWGIELNLISLLFSSISPVLNKFSLTSLSPVVGGI
                     FTSAFAAIFTFATILITHQHVSLTNLKSLWLWLLGGTNAIGIILQYIALSTLSPITVTL
                     IARMYLVYVFFLSYIFLKEKITKWDYLAIILCILGSFFISGSRLQFSDNLLGLICAFIY
                     PLMYAANNIVAKYLVSDEEPNNVLFFNHFTSALLLFCYALIIGTSFSHISSQAVAFNFG
                     GAFFNGFMSLLLFYTSLQFITAGKANIVRAFGPVIVIIYSSFFFPVQVTPSLVLGAILV
                     ILASTIVTFTRTNYE"
     CDS             complement(12949..13596)
                     /locus_tag="ctg27_14"
                     /transl_table=11
                     /translation="MSTKKRVYIPKNKTNGQIKGKRKIWVENVKFLTLEEYDQLRETIK
                     LHSRPELVNRNLLLIAIALNNGLRASDVVTLRVGHVLNKTKTRVIEQKTGKAKTLFWNN
                     CLAEIIDYLNDLDYKDENDYLFPGKQEGHFSVHGFYEMLQRMARKTENNKIVAKIGTHS
                     FRKTFGRQLYKKGVNVEIISQLFNHSSERNTRHYLGIEQEDLDKVVQNFKFE"
     CDS             complement(13613..14467)
                     /locus_tag="ctg27_15"
                     /transl_table=11
                     /translation="MLYNAALVLEGGAFRGQYTAGIVDTFLAHHIEFRSVIGVSAGSLC
                     GVNFVSKQYGRAANININHRHDRQYISMARVFKKQIINLDYLFEDHGYSWQNFNEAAYR
                     RSASHFTAVATSVKTGKTVLFTDPVGEELTNALKASSSMPFLSDPQETSQGPCLDGGVT
                     DSIPFDIAQQQGYDKIVVVRTRDVNYRKKPSSSAVKKLYDMVYKDYPEFAKAGINRPLL
                     YNQQIAEINRLSREGKIFNIAPSKPIKIKRIEGNIKKIRALYETGRKEGEEIVPALVDY
                     LAN"
     CDS             14904..15278
                     /locus_tag="ctg27_16"
                     /transl_table=11
                     /translation="MLERKEHKKMYKSGKNWAVVTLSTAALVFGATTVNASADTNTKNN
                     DSSTIQVTIGDNDIAVKSVTLGSGQVSAASDATIKNSANANSASSAANTQNSNSQVASS
                     AATTSSTSSAASCAPGMGIS"
ORIGIN
        1 tccaagacgc tccagtcaat tcaatgtgat taagttgtcg aaccgccgta tacggaaccg
       61 tacgtacggt ggtgtgagag gtcgataatt gaactaatca attatctcct actcgattca
      121 tattcattaa tccaagtgaa tgcccattaa atccactatg ctgatcaata tcaaatccaa
      181 ttccattatc aagaatctct aactgaaggt aactgctgtg atccgtaaca ataatactta
      241 tttctgttga atgagcatgt ttaattgcgt tattaattgc ctcttgtgta atgcggtaaa
      301 gaacgttttg aatgtttttt tgtaattttt cagcagaggt aagggctata acatcaattg
      361 tgattcctgt actattttga agacgtttcg ccaaagcttt gattgccgga attaagccaa
      421 aattgtcaag aactgagggg cgaatatcaa gtgcgagccc tttaatctct ttaagggtcg
      481 tttgtaactg cttttcgatt gcagcactca ttgattgaaa ttgctcagta tttctttgat
      541 tttgcaccgt tgctaatctt tgaatgccca ttattgctgc atagattccc tgtgcaacac
      601 tatcgtgaag atcttgtgaa attttttgcc gttctttttc gtgcgcttca tttacgtatt
      661 gattaagaat tcggtgctct tcaacctgag aaagacgctg ctgttgctca cgattttcaa
      721 gagttagggc aaagacattt tctttatcat caagaggacg gtaaaccatc gaaaagtgaa
      781 agggatgagt agcattggaa tgaaatgtta tcggaactgc agcttccttt aaccgctttt
      841 taatcagaca tgacgcacag tcatcatttt ccagttgtga ccaagcgttc tttccaattt
      901 gtaataggta attgacatct aaattaagca tagtaactaa ccgttgtgcc ggctcattac
      961 tgactaaaag atcatcattt ttaaataaga agattgcatc tggtgattga ttaaaatatt
     1021 tttgtatcca attagctgtt tcaagcacga tctgcttcct ccccaataaa attccccaat
     1081 tgtccttaca atattcctat tttatataat aacgctttct cgagttagaa gcaacgctgg
     1141 cccacttaaa aggcagggct aagaaaagct ctgcttcttt agccctgccg tctgagtttt
     1201 aaggatgtcg tggtaatccc atcgatggtc cctggaaata cttagttgca ctaaaatcaa
     1261 attccggatc ctgaaattcg cggtaatgat caaaatcagc ttgaatctgt tgaatttggt
     1321 cgtccaattg ttctaactcc gcatcttttt ccagcgaact catttgttgg ctcacttctt
     1381 gttcccgatt ttctagcatt gttcgtctaa ttgttaagtc atttaaaaca agggaaatga
     1441 gcttctgaaa atcaggattt gtcattgaat ctttactttt catttaaatc gacctcacga
     1501 tagtttaaat ttgaaaattc gttacttgag cgatacgtaa gggggtggca gacgcactta
     1561 ttagtgatga aactacgtaa tcgccagtca tcattattat caacccaagt agtaacttgt
     1621 tcattgctaa ctgaaaaatg agctaatgaa tagtgattgt gctgacttgt tgcaatataa
     1681 gaattaggtg tacgggcaag aacggcaagt gaatttttgg tgatatatgg ataatcaaca
     1741 gccaaggtta aataatcctg aacaatggaa aattggttag tacaagcaat aattgctgag
     1801 aggggaccat gatgatcata agggggaata tcacagataa tctgcacagc cggttcttga
     1861 ccaaccaact ttaatatatg cgctcgattt atttcattag cacaaacaac gatctgctga
     1921 caaaggggtg ttaatttctc gacagctagc tctatattgg tagctggtaa tcctggaaca
     1981 tgataagtag ctttatcttt cccaaaacgg gtagatttac caccagcata tactaatcca
     2041 atcattctgc atcccccttt acttgtttta agtagtcata gcaccaattt acaattgcat
     2101 cttttcctaa taagtcagcg gttgttccat taaagatact acctgtttta agagggggag
     2161 tatgagcaac attggtagaa tcttcgccag gctttaataa taaaatttgc ggatattgag
     2221 tggcttcctt atggccttca atcaagataa aatcattgtc ggtacttaat aattcaacca
     2281 tttccgttaa agacggcaca ttactttttt gatgaaagaa aaattcagtc gcagattgta
     2341 aaataacctg tttagctcca gcactactca ttctagcact atcagtagtt ggcacatcca
     2401 ttgcggcatt atgggcatca tgtttaagag cagctactcg atacccttct tttgagagcc
     2461 tttcgattaa agtcgtagtg ataagagtct tgccgctttt tttatgaccg attatttgaa
     2521 gggtaatagc catgcgtctg tctccgttcc gaccttcatt ggagtagtac tatgcggaat
     2581 cagtgctaaa caggttgtcg tctggaggtt agctaatgag ccagatctgt tgattccatt
     2641 tggataaaca taaaattgat tatctttgaa tttataagta caacgaagat accgatcaaa
     2701 cccatttgtt ttattatatg gggccgttaa tattgcccgt acttgcttaa ttcggctgac
     2761 ttggtgttga taacggcgaa tcagcggttc catataaagg taaaaaccag taaaacaagc
     2821 tcctggattc ccagaaaggg ccattattaa cgtactattt tgaacaaagg cagtcgtaac
     2881 gcttcctggt cgttgtttaa tcttattaaa aagcaattca tcagctttac gtgcttcatc
     2941 tccaataaaa tcaaaatcac caactgaaac accaccatca gtaattacaa tttcatgcgt
     3001 tgctatttgt tcttcaagag tctgcttgat aagatcagca tcatctggta attgggtttc
     3061 aaaatcaaca atcccaccag tttcttctac aagatttttt aacataatac cattactatt
     3121 aaagatcttt cccggttcaa tcgtggcatt aggtcctaat aattcagttc cagtggcgat
     3181 aattgcaatc cgtggttttt tataaactgt tacttcttga acaccaaaag ccgttaaaac
     3241 tgctaggcca ccgggattta tttcctggtc ttttgctaaa acgatatcac cgctttttac
     3301 atcagtacca gcttccgtaa tgttagtctt gttacatcag taccagcttc cgtaatgtta
     3361 gtcttgcttt cagtcgtaat aatttgaacc ttattttcat ctttagcagg ccgcgttttt
     3421 tcaattcgaa ttacttttcc tacatcagaa gggacatatg caccagtcat aattcggacc
     3481 gcatcccctg attgtaatgg ttgatcccaa gttgctccag cttgaatctc tcctcggacg
     3541 ttaaattcgc gagggaaatc atgatcatcg ctggctaaaa tggcataacc atccattcca
     3601 gcccgtcgaa aatgaggata atcataatgg gcatgaacat ctttagctaa aacacggtgg
     3661 ttagcttctg ataacgggat tgtctctgta gctgttttaa gggaaatttc gttaatcttt
     3721 ttctgtgcct cggcaacaga gattggaatt cttctagtga gcatggtgat gaacttcctt
     3781 tcgttgagaa ctgctttcaa ataataaatg ttcatattct ggcaaaatta gtttgtttat
     3841 agccgtttga caggcattct gggaaccagg taaacaatag gtaagctgat tgcggaaatt
     3901 aaatccggct agggcttgtg atgcaagcgc acgagtacca atttcctcaa aggatatctg
     3961 gcgaaacgct tccccaaaac ccggaattag gcgtttgagg agtggacgaa tagccggaat
     4021 agtaacatca cgctgagcaa ttcctgttcc accattagta atgatgatat caagagcttg
     4081 ttgttctagt tgaaggtagg cagtttgaat attgacaata tcatcattaa cgattacccg
     4141 atcaactact gataagcccg cgttagccat cttcatagca attaattttc cagaagtatc
     4201 gctatctaat gttcggctat cgctaaccgt taaaattgcg atttttttca taataggtct
     4261 tctttcatca aaatatttaa cgacttaaac tgtttctggg caatcgccga agtaggtaag
     4321 tcatacataa caatcttacc attcttgaat atacttactg gacgattttc ccatttaaaa
     4381 tgaagaaata atcgatttgc gttaattaag agctcttttt tagccaaaaa ttctttaagt
     4441 ctgccaaaat taataggttt ctctttgact gtataatatg cattttcccc acataacata
     4501 tgtaattctg gtcctgattc ttcttctaaa gaaatactgc taggcttagc acaggcggga
     4561 caatggtgat ttttattaat agcaaactta ctaaattgca ttgaccaatt gtcaaccgtg
     4621 atcaattcat taaaattaac ctgtgttttg tcaaccagat aatgaagcgc taaagatacc
     4681 tgtagtcccg ctacaatcgg aattaaagca gtattaaccc caattaaatc acaatcgttt
     4741 tgttttaatt cattaatatt aggaaaaaga cagttcaagc agggatgatt ttgtggcgaa
     4801 atcgccatta cgttcccata ggttcctgca cagctggcaa acagataatc aaagtttttg
     4861 atgattgcta atttgtttaa tagatcccgt gcttgataat tatcaagaca gtctaaacaa
     4921 agggtaaact gatattcgtc aataaggtca gcagtaatcg gcgctgggat cgcagtaatt
     4981 tgacatgctg aattaatttt atgtaaatgt tctttagctg cttcgacctt aagccgttgt
     5041 ttgctagcat cttcttcggt gaaaagtgat tgacgttgaa gattagttac gtcaacagtg
     5101 tcaggatcaa tcaagacaag tcttttaact ccagcacgga caagttgctc ggctgtataa
     5161 cttcccaatg cccctacacc gacaatcata atagttgcat ggctaatttt ttgctgacca
     5221 atactaccaa tttgatgtac cctttcttga cgatcgtaac gattcatgga tattagcacc
     5281 tcatttagtt caaaatatag gtatttccct agtcgtagta tagcagttat ggtgctaatc
     5341 tttacattag ggaaaagact tactttattt ttaatattgg taagccattc aataaaggag
     5401 gtcaatcaac gatgaagtca cggttcttta acaaggttga taagtttaat ggaaccttta
     5461 cacaacttga agaaaatagt cgtcgttggg aaaagcttta tcgccagcga tgggcgcatg
     5521 acaaagttgt ccgaacaact catggagtta actgtacagg ctcatgttct tggaatgttt
     5581 acgtcaagca aggaattatt acttgggaac accaagccac agattatcca tcatgcggcc
     5641 ctaatattcc aggatatgaa ccacggggat gtcctcgggg agctagtttc tcttggtatg
     5701 aatacagtcc cgttcgaatt aagtatccat atattcgtgg caaattatgg gagctttgga
     5761 ctgctgccaa ggaagaacat gaaaatccct tagatgcgtg ggcaagtatt gtcgaagatc
     5821 cagaaaagtc taaaaaatat aagaaggtcc gaggacacgg tggcttaatt cgtgttcatc
     5881 gttatgaagc attagaaatg atttcagctg cttgcttata cacaattaag aagtatgggc
     5941 ctgaccgcat tggtggtttt accccaattc ctgcaatgtc aatgatgagt tttagtgccg
     6001 gagcacggtt cattgcctta atgggtgggg aacaaatgag tttctatgat tggtatgctg
     6061 atctaccacc tgcatctccc caagtttggg gtgaacaaac tgatgttcca gaatctgcag
     6121 aatggtataa cagttcctac attattatgt ggggatcaaa cgtcccatta acacggacgc
     6181 cggatgcaca cttcatgaca gaagttaggt acaaaggaac aaagattgtg gcagttagcc
     6241 ctgattatgc tgaaaatgtg aaatttgctg atgactggct tgcaccagaa ccaggtagtg
     6301 attctgctgt tgctcaagcc atgacctatg taattttaga tgaattctac caaaagcacc
     6361 cagttaaacg tttcattgat tattccaagc gatttactga tttaccattc atggttgaat
     6421 tggaaccaag tacagcaaat ggtgatcact atacaccagg tcgcttcgtc cggattagtg
     6481 acttagttga tgatgatacg atagtcaatc cagcatggaa gacagttgtt tatgaccaaa
     6541 acaaccacaa gattgttgtt ccaaatggaa cgatgggaca agaatataat gctaaggaaa
     6601 aatggaatct tgaattatta gaccaaaatg gtaataagat tgatccggca ctctctatta
     6661 atgatcaaga tggcgaaact gaacaaattg ttgctgattt tccagcattt agtaatgacg
     6721 gaaacagcgt tgtgcaacgt catttaccag ttaaaaagct caaattcaca gatggcaaag
     6781 aacacttggt aactaatgtt tatgatctga tgatggctca aatgggaatt aatcggactg
     6841 gtaatgatga acttgctgct aaagatgcaa tggatgctaa gagctacttt actcctgctt
     6901 ggcaggaaag ccgttcggga gtaaaagcag agcaagttat tcaaattgct cgtgaatttg
     6961 cccaaaacgc ggccgaaaac gaaggtcgga gtatggtaat catgggtggt ggggtcaacc
     7021 actggttcaa tgccgatatg aactatcgaa acattattaa tatgctgatg ttgtgtggtt
     7081 gtgttggtat gactggtggt ggttgggctc actacgttgg tcaagaaaag ctccgtccac
     7141 aagaaggttg ggcaaatatt acttttgcta atgactggga aaaaggtggt gcccgtcaaa
     7201 tgcaaggtac tacttggtat tactttgcaa ctgatcaatg gcgttatgaa gaaattgata
     7261 accaagctca aaaatcacct gtttggaaga gtaaacattc ctacttacat aatgctgatt
     7321 ataatcaaat ggcaattcgt ttaggatggt taccatcata tccacaattt gatcgtaatc
     7381 cgttatcttt tgcaaaagat tacaatacaa ctgatattaa tgaaatttca aagaaagttg
     7441 tcgatgaatt gaagaagggc tctttacatt ttgctgctga agatcctgat gctaaccaaa
     7501 atcaacccaa agcgttcttc ttatggcgtt caaacttatt tgcttcttct ggcaaaggtg
     7561 ccgaatactt tatgaaacat ttattaggcg ctgaaaatgg attacttgct aaacccaatg
     7621 atcgggttaa gcctcaggat atgatttggc gtgacaaggg agcaattggt aagttagatc
     7681 ttgttgttga tatggacttc cgaatggttt caacaccaat gtactccgat gttgtcctac
     7741 cagctgctac ttggtatgaa aagaaggacc tttcatcaac tgatatgcat ccatttattc
     7801 acccatttaa tgcagcagtt agtccaatgt gggaatcaaa gtctgactgg caacaattca
     7861 agctcttggc taagactgtt tctgaaatgg caaagaaata catgccggga actttctatg
     7921 atcttaagag cgcaccacta ggacataata ctcaagggga aatcgctcaa ccatacgggg
     7981 aaattaaaga ttggaagaac ggtgaaacag aaccaatccc tgggaaaacc atgccttctt
     8041 taaaattagt tacccgtgat tatactaaga tctatgacaa atacatcact cttggcccta
     8101 atatagtaaa taattataac tataaagttg atgatcaata tgattatctc aaagacatga
     8161 atggaattgc tagtgaaggc attggtgcag gctgtccatt acttgatgaa gacgaaaaag
     8221 tatgtgatgc aatcttacgg atgtcaactg cttccaatgg taaactcgct gatcgagctt
     8281 gggaaaagaa gcaagaacgg actggtgaac atttgacaga tattggtcgt ggtcatgctg
     8341 atgattcaat gtcgtttaag caaatcactg ctcaaccaca agaagcctat ccaacaccaa
     8401 tcggaacttc tgctaaacat ggtggagctc gctacacacc attttcatta atgactgaac
     8461 gaaatgttcc tacatttact cttacaggac gtcaacatta ctaccttgat catgaaattt
     8521 tccgggaatt tggtgaaaat atggcaactt ataaaccatc tttaccacca gttgtaatgg
     8581 ctccaggaga tgttgatgtt ccgccagtaa aagatgaagt tacacttaaa tatatgactc
     8641 ctcatggtaa atggaatatt catacgatgt actacgataa ccttgaaatg ttgacattat
     8701 tccggggtgg tccaactatt tggattagtc cccaagatgc cgataagatc aaggtaaaag
     8761 ataatgactg gattgaggtt tataaccgta atggggttgt tactgcgcga gcggttgttt
     8821 ctgttcggat gcctgagggg tcaatgtaca tgtaccacgc ccaagataac gaaatttacg
     8881 aacctctttc taccattacc ggtaatcgtg ggggatcgca taatgcacca acgcaaatcc
     8941 atgttaagcc aacgcatatg gttggtggat atggacaatt gagttacggt tggaattact
     9001 atggaccaac tggaaaccaa cgtgatcttt atgcaaatgt aagaaaactg aagaaggtga
     9061 actggagtga agattaaagc acaaatcagc atggtcttaa acctcgataa gtgtattggt
     9121 tgtcatacct gttcagtaac ttgtaagaat acatggacta atcgcccagg cgctgaatac
     9181 atgtggttta ataatgttga aactaagcca ggtgtcggtt atccaaagcg ctgggaagat
     9241 gaagatcaat accatggagg atggaccctt aattcaaaag gcaaattaaa attacgtgct
     9301 ggaagcaaat taaataaaat tgctcttggc aagatttttt acaataatga tatgccagag
     9361 ttagataact actacgaacc atggacctat gactataaga cattatttgg tcctgaacaa
     9421 aagcaccaac ccgtttctcg tcctaagtcg caaattactg gcgaagggat ggaattaacc
     9481 accggtccta actgggatga tgacttagca ggatcaactg agtatgtcca acaggatcct
     9541 aacatgcaaa aaattgaagg ggatattaaa aataactttg agcaggcatt tatgatgtat
     9601 cttccccgat tatgtgagca ctgtttgaat gcgccttgtg tagcctcttg tccatcaggt
     9661 gcaatgtaca aacgagatga agatgggatt gttttagtag accaagaacg ctgtcgagga
     9721 tggcgatttt gcatgactgg atgcccatat aagaaggtct actttaactg gaagactcat
     9781 aaggctgaaa aatgtacttt ttgttatccg cgaattgaag aaggccaacc aacagtttgc
     9841 gccgaaacct gtgtcggtcg aattcgatat attggtgcta ttctatacga tgctgatcga
     9901 gtagaagagg cagcatcaac tcctgatgag agtaagctgt atgaagcaca acttggctta
     9961 ttcctcgatc ccaacgatcc tgaagttgtc aagcaagcac tcaaggatgg catttctgaa
    10021 gagatgattg aggctgcaca aaagtcaccg atctataaaa tggcagtaaa agaaaagatt
    10081 gccttcccac ttcacccaga ataccggaca atgccaatgg tttggtacat tccgccgcta
    10141 tcaccagtta tgagttactt tgaaggacga gactcaataa agaatcctga aatgatcctc
    10201 ccaggaattg atcaaatgcg ggtgcctgtt caatacttgg caagtctatt aactgctgga
    10261 aacgttcctg tcatcaagaa agccttatat aaacttgcaa tgatgcggct atacatgcgt
    10321 gctaagacta gtggtcggga ttttgatagc agtaaactag aacgagttga tttaacagaa
    10381 gaacgggcaa catcacttta tcgtttactg gcaattgcta aatatgaaga ccgctttgtt
    10441 attccaagta gccaaaaggc agaaatggaa gatgcacaaa ccgaacaagg tagtcttggc
    10501 tatgatgaat gtgaaggctg tgcattagct ccccaacaca agagtatgtt taagaaggca
    10561 gaagctggca aatcaactaa tcagatttat gctgatagtt tctatggagg gatttggcgt
    10621 gattgatttt agacgattga cagatttaaa ggatacattt gccgttcttt cccgtttgat
    10681 tgactatcct gatacagaaa cgttttcacc agagattcgt caattattac ttgcggataa
    10741 cgcattatca actgcaacgc ggggagaatt attaagcctt tttgatgaat tagccgcact
    10801 atcttcaatc gaagtccaag agatgtacgc tcaccttttt gaaatgaacc gacgttatac
    10861 tctttatatg tcatactata agatgaccga ttcccgtgaa cgagggacca ttttagcacg
    10921 gttgaaaatg ctatatgaga tgtttggtat atcagaagcg accagtgaac tttctgatta
    10981 tttgcctcta ttgttagaat ttctagcata tggcgattat actaatgatc cgcgtcgtca
    11041 ggatatccaa ttagcattaa gtgtgattga agatggaact tatacccttt taaaaaatgc
    11101 agtgacagat agtgatagtc cctatattca gttaatcagg cttacacgtt cattaattgg
    11161 ttcgtgtatt aaaatggagg tgcaagaaga tgcataatgg ctggtcaatt ttcttatggg
    11221 ttatttatcc atatataatg ttggcatcat ttttcattgg aacatttgtt agatttaaat
    11281 atttccatcc ctcaattact gccaaatcaa gcgaactttt tgaaaagaaa tggctaatga
    11341 tcggaagcgt tactttccac attggaatta ttttagcttt ctttggtcac tgcttaggaa
    11401 tgtttatccc agcaagttgg accgcttatt ttgggatcac tgaacatatg taccacatct
    11461 ttgggtcatt gatgatggga attccagcag ggatccttgc atttgtggga attgcgattc
    11521 tgacttatcg acgaatgact tgttctcgtg tttataaaac aagtgatatc aatgatatta
    11581 ttgtcgactg ggctttactg attacaattg cattaggtct agcatgtact attacgggtg
    11641 catttatcga ttacaactat cgaacaacga ttagtccatg ggcaagaagc ctatttgttc
    11701 ttaatcctca atggcaattg atgcgttcag tgccattaat ttataaaatt catgttcttt
    11761 gtggattagc aatttttggt tacttcccat acacccggtt ggtccacgct ttaacactac
    11821 cttggcaata tattttccgt cgttttattg tctatcgtcg gcgcgcaaga gtttattaat
    11881 atataggaga agatataata aaagcatcag atttctttac agggaaattc tgatgctttt
    11941 atattgcgat tattcgtaat ttgttcttgt aaaggtaaca attgtactag ctaaaattac
    12001 taaaatagct cctaaaacta gggaaggagt tacctgaaca ggaaagaaaa atgaagagta
    12061 aataataaca attactggcc caaatgcacg aacaatattt gctttaccag cggtaataaa
    12121 ctgcaagcta gtatagaaaa gaagtagtga catgaaacca ttaaagaagg ccccaccaaa
    12181 gttaaatgca actgcttgac tagaaatatg gctaaatgac gttcctatta taagagcata
    12241 gcagaaaagt aaaagagccg aagtaaaatg gttaaagaat aagacattat ttggctcttc
    12301 atcactgact agatacttag ccacgatatt gttggcggca tacattagtg ggtagatgaa
    12361 tgcacaaatc aatccaagaa ggttatcact aaattgaagt cggcttcctg aaataaagaa
    12421 agaaccgaga atacaaagaa taattgctaa gtaatcccac tttgtaatct tttcctttaa
    12481 gaagatataa gataggaaga aaacataaac taaatacatc cgagcgataa gggtaactgt
    12541 gattggactt aaggttgaga gagcaatata ttgaagaata attccgattg catttgttcc
    12601 acccaaaagc cataaccaca ggctcttaag attagtcaaa gaaacatgct gatgagtaat
    12661 gaggattgtt gcaaaagtaa aaattgcagc aaacgcacta gtgaaaattc ctccaacaac
    12721 cggactcaag ctagtaagtg aaaatttatt aagaaccgga ctaatgctac taaataggag
    12781 agaaatcaga tttaattcaa ttccccatag ttgcttcttt ggtacacttt ttatattcat
    12841 ttagtcacat ccaatacttt ttattacttt aattctaatg aattatattc ctaagtctat
    12901 taggaaaatg actaaatatt ttagtttaca taatattcag aataataact attcaaattt
    12961 gaaattttga acaactttat caaggtcttc ttgttcaatc cctaggtagt ggcgcgtatt
    13021 tcgttcagag gagtgattaa ataactgcga aatgatttca acgttaacac ctttcttata
    13081 gagttgtcga ccaaaagttt ttctaaaaga gtgtgttcca atcttagcaa cgattttatt
    13141 gttttccgtt tttctagcca ttcgttgaag catctcataa aagccgtgta cagaaaaatg
    13201 gccttcttgt tttccaggga aaaggtaatc attttcatct ttataatcta agtcattaag
    13261 gtaatcaata atctcggcaa ggcaattatt ccaaaagagc gttttagctt taccagtttt
    13321 ttgttcaata acacgggttt tagttttatt tagaacatga ccaactctta acgttacaac
    13381 gtctgatgct cgtaatccat tattgagggc aattgcaatt agtaataggt tacgattaac
    13441 caattcagga cgagaatgca atttaattgt ctcacgtaac tgatcatatt cttcaagggt
    13501 caaaaactta acattttcta cccatatttt ccgtttaccc ttaatttgac cattcgtctt
    13561 atttttggga atataaacgc gttttttagt tgacataata tttcttcctt tgttaatttg
    13621 cgaggtaatc aactaaagca gggacgattt cctctccttc tttccgccca gtttcataaa
    13681 gtgctcgaat cttcttaata tttccttcaa tccgcttaat cttaattggt ttagagggag
    13741 caatattaaa gatctttcct tcacgagata aacgattgat ttcagcaatc tgttggttgt
    13801 agagaagggg acgattaatc cctgctttag caaattcggg ataatcttta tataccatgt
    13861 cgtataactt ctttacagca gaactggagg gtttctttcg gtagttaaca tccctagtcc
    13921 ggacaacaac aatcttgtca tatccttgtt gttgtgcaat atcaaatgga attgaatctg
    13981 tgaccccacc atcaaggcaa ggtccctggg atgtttcctg tggatctgaa agaaatggca
    14041 ttgatgagga agctttgagg gcattggtta actcctcacc gacaggatcc gtaaataaaa
    14101 ctgtttttcc tgtttttact gaagtagcga ctgctgtgaa atgagatgct gaccgtcgat
    14161 aggctgcttc attaaaattc tgccaagaat atccgtgatc ctcaaaaagg taatcaagat
    14221 taattatttg ctttttaaat acacgagcca tcgagatata ttggcgatcg tgccgatgat
    14281 taatattgat attagcagcg cgtccatatt gcttagagac gaaattaact ccacaaagcg
    14341 aaccagcaga aacgccaatt acacttcgaa attcaatatg gtgagcgaga aatgtatcaa
    14401 caattccggc agtgtattgg ccacggaatg cgccaccttc taaaactaaa gctgcattat
    14461 ataacataaa atgaaataac tcctttttgt ctgccaaaaa tagcaaaaat gacctaattt
    14521 ttagtgagac actttttcaa taaaattata caacagtctt acgcgaaaat ataggatttt
    14581 aaaagcttgt tatatcaacg tttattctcg gttaatgtaa gactctttta tcaaaagagt
    14641 cttactaatt ttaaaataat acaaaaatag gggtaaaaac agcttttgcc tctcagacga
    14701 actgaaatta attttgatga gtagtagatc gttacacttc gtctcagaag aaaaacgcat
    14761 attgctatca aaaaaatgag taaatattta aatatgaact ttttatgaag aaactattga
    14821 taatttaaga taatcataat aaaatagtgc acagttaatt gttaaacgtt tagcaaaaaa
    14881 ggtaaagaaa cggggttatt tctatgctag aacgcaagga acataagaaa atgtataaaa
    14941 gcggtaaaaa ttgggcagtc gttacactct ctactgctgc gttggtgttt ggtgcaacaa
    15001 ctgtaaacgc atccgcggac acgaatacta aaaataatga ttcttctact atacaagtta
    15061 caataggcga taatgatatt gctgttaaaa gtgtgacact tggtagtggt caagttagtg
    15121 cagctagtga tgcgactatt aaaaattctg ctaatgcaaa tagtgcttct tctgccgcta
    15181 atacacaaaa ttctaacagt caagtagcaa gttctgctgc aacaacatca tctacaagtt
    15241 ccgcagcttc atgtgcgccc ggcatgggta ttagctaggc ggtgagagtc cgctatggac
    15301 cgtagtagtc ggaaccatga gctgaggaca agggtgtcca ctgtgaggtg gaatctgaag
    15361 gaagt
//
