LOCUS       c00025_JAJGTX0..       12151 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJGTX010000060.1 Limosilactobacillus reuteri strain CC-AA2-2
            scaffold60, whole genome shotgun sequence.
ACCESSION   JAJGTX010000060
VERSION     JAJGTX010000060
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 11:16:21
            Original ID  :: JAJGTX010000060.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 127493
            Orig. end    :: 139644
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12151
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[132493:134644](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7151
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12151
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12151
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             430..1824
                     /locus_tag="ctg25_121"
                     /transl_table=11
                     /translation="MQKLSIKQLIIITLCLLVLVVGCMTIHQRRHFNKNVKIDNVSVGG
                     LTAKQALKKLQDNPQSPKIYVNNELVFTDKQSVAKFSSADEQKIENALHSQYTFFPSSK
                     AKNIAIKPQNVNQDEVSKIDQAVSQKVTELNNGRKAPVDAYAVYENGRVQVKPAVGGTQ
                     YSLDGLHNKLEKEVAGGTVRLKPKYTAPLSANSKTVQNEKAKLEELSKRTVTYQVQNKK
                     YQLNCGEIITRATYQNGKYHFDTGAANSKIDEINNTQATLGKSFEFKTHDGSVIKTTAA
                     GSYGWKISKKQAGKTLTNALVANKQTVNAKNDIYGKGYNQQGTGYNTTSNNGIGDTYAE
                     VSLADQHAWFYKNGKCVLSTDIVSGTNNKDNETPKGVWYIMYQQTPSVLRGLNDDGSKY
                     ASKVQYWSPFTDSGCGFHDASWRHDWSKQAYLAKGGGSHGCINMHPDVAGQAFSDLHKN
                     EPVVIY"
     CDS             1948..2112
                     /locus_tag="ctg25_122"
                     /transl_table=11
                     /translation="MVDLDLETKKNLVIINLFYIGLIALYCILHAGPLNFLVFLGMLVI
                     ANVAEILIG"
     CDS             2245..3552
                     /locus_tag="ctg25_123"
                     /transl_table=11
                     /translation="MIKLTIFQAFINSFSNIFEIIIIYRLMISSPVGKSILHDILWSLI
                     IISIPLITIGSINLVFLVIYLFLFDQIRSNKNKVMDSILAMFTAVIMSSLFDLVDHYTH
                     TLLLQKKSDLSLWGWLIPLNDFLTTLLIGILVVKIIRPRISWLMTSLSRPTWLWRITAI
                     LFMLYIWLTAIMEKNGIANRYASMLLIVYFIIIIVSAIGFIDFMRTSKRAQQQQQIIDK
                     YQAQITNANQMNQQYNEIRRERHDLRNMLLSIQGYIRDHKDKEAEKLLSTFLQNDTTEK
                     HYDEVDLALDKIKISGLHNLIKEKAYKIVEKGIPFSFEVNAEIDKLPGSEIKTARIIGI
                     LMDNAIEATFKQTKPYIQFALLKHSPKVYELVIANSIEQKLNINTALKFEHSTKEGHQG
                     IGLSNVTQLVENDDHYSFSAEVKDKVVMMTCFIQRK"
     CDS             3560..4327
                     /locus_tag="ctg25_124"
                     /transl_table=11
                     /translation="MLKVIILENDDYQADYTERLVSQRKLINATPNSYDIELYLRTNDP
                     QKVIDSIKDEAYLAILDIELDNQLSGIDVAEQIRKKAEFAEIIFVTAYQEYLPYTVSRR
                     IEPFDYISKGKQIESIADRLRIDIDEAYARYQNYMNSNQKHQEKFTYEPTHGVKRQVDF
                     ENLYYIESVKNTNRRLRIVGKDIRIEYRGELGQINNKHLLKVNQSTLINPKAIQEFNRK
                     ERVVYFDENQEIKITVSYRKIKSLINFLEKENH"
     CDS             4566..4724
                     /locus_tag="ctg25_125"
                     /transl_table=11
                     /translation="MTYRKLNFDELSKVSGGWSLSSQVNELVKDVVNSLNKWAQSCYAG
                     YKDSPFH"
     CDS             4737..4922
                     /locus_tag="ctg25_126"
                     /transl_table=11
                     /translation="MVKVRINKQFYKDFNFYFYMLFIVLWIKPLIDAENGYELTYCLVF
                     LVGAIIATLLTIFKNK"
     CDS             5001..7151
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 330.6; E-value:
                     3.1e-100)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_127"
                     /sec_met_domain="TIGR01193 (E-value: 3.2e-276, bitscore:
                     911.6, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.3e-39, bitscore:
                     126.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKINYPHYVAQVDEADCGVAALAMILHNFGSVYPIAKLRDLARTT
                     KQGTTALGLVKAAKHLGLDVTPIQADISLFNDPEITYPLIAHVIKDDLLHYCVVFKADQ
                     DYIYVADPDPATKVQKMTRDEFGRLWSGVSLLFSPAKGYTPQKEPLAGLMTMFRQLTNY
                     KKDISGIIIAALLITLISIVGSYYLQLIIDRFIPSKNIDGLAILAGSLLVVYVFNSLFN
                     YLRDVLLTRLDQKLTSQISLRYIHHVYRLPMRFFSTRKTGEITSRFNDINKIIDALSST
                     IISMFLDVGVMVIIGIVLSLYDRSLFLTTISTIPIYVIIIYAFNKRFAKLDQEQMESNA
                     QLSSAIIEDLKGVETLKVLQLENIRYKNVEKQFADFLRKNLTYVKTKSFQDAIKMWIQY
                     GLVTIILFQGAVLVIQGRLSIGTLMAFNALLAFFISPLQNIINLQPKLQEAKVANNRLN
                     EVLQVDTEKADTNSQDQVDLVGPINIHHVDYSYEYSRPILQDINLQIGCNDKLTIVGLS
                     GSGKSTLAKLLVGFYLPTQGQIEFNQHKTTEINLCDIRQYVHYLPQLPQLFSGTIKDNL
                     LMGLDREVSAEEIDNACKLALIYNDIQEMPLKYETKLDEEATALSGGQKQRLTIARALL
                     TSARVLIFDESTSSLDPITEKRIVENLLEIEDRTMIFIAHRLSIAKKVNKVVVMRDGKI
                     IEQGTHQELLNYHQEYYNLWNA"
     CDS             complement(7327..7512)
                     /locus_tag="ctg25_128"
                     /transl_table=11
                     /translation="MKIHFNKDFWRDGFFYVYLLLLFLWIAPFSDGSLPLDESLLCIFF
                     IIFTIGSMLAIMFNKD"
     CDS             complement(7665..8093)
                     /locus_tag="ctg25_129"
                     /transl_table=11
                     /translation="MSKYKVTATKTTTGMQVSAGTRGFEITFDEPESTNTGMNPVEILL
                     ASFGACQAITAQALAKKRNFDLRAFWVTIEGDLGREDVADGKNVRKFTEIRYQPHLRSS
                     ESDEDIKKFLADVAAKCPVENTLTYGTKFVQDGFVKVD"
     CDS             complement(8161..9156)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 300.4; E-value: 1.8e-91)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_130"
                     /transl_table=11
                     /translation="MTKILMTSVRDDEQTAINEYAKEHNIEIITTPKLIDDAVELTAGV
                     DGLVIQQRSKVPATIYEKLHANGLKQIATRTAGFDMVDVKKANENGLVVTNVPAYSPRS
                     VAEFALMQIFRLLRKTYRFDHQVAENDFRWFSDEQSTEIHTATVGIIGVGRIGGTLAKL
                     LHALGATVLGYDTNPRTDLDGIVQFVSKEELLKQADVVSLHVDLNPTSKGLLTANDFAM
                     MKPTAGLVNASRGPVVNTADLVAALKKGTIAAAALDTFEGEETVAATDRREKGLDDQPL
                     VKELHEMDNVILTPHIAFFTNLAVKNMVDISLNDVMTILNEGKSPHEITL"
     CDS             complement(9158..10345)
                     /NRPS_PKS="Domain: Aminotran_1_2 (36-387). E-value:
                     3.6e-72. Score: 235.2. Matches aSDomain:
                     nrpspksdomains_ctg25_131_Aminotran_1_2.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 273.1; E-value:
                     6.2e-83)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_131"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.2e-07,
                     bitscore: 22.3, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPATKKEILSRLNNNFAKLTPGGIREFDYQVSTIPGIIKLTLGEP
                     DFNVPNTMKQAAIDSINANDSHYAPGNGTLALRQAIAHFMQDRYQLDYDPENEIAVTVG
                     ATEGIFASLSTTINPGDEIIIPTPTFPFYIAVTKILGGIPIEVDTSSDDFVLTPARLQS
                     ILEEHPNAKGLILNYPSNPTGVTYTQDQIKALADTVKSTSLIVIADEIYSELVYGATHT
                     SIANYIPEQTLILNGASKSHAMTGYRIGFIAGPQELMKSVSAIHAMLVTAASNPAMAAA
                     GAAFGTDEGKTATQEMKEAYKQRRDFVVNSLQKLGFELINPQGAFYVFAKIPEQYGNDD
                     LKFATNLANEGKVAVIPGSFFGAGGQGYVRISYATSMENLTGALDNIAAFINKED"
     aSDomain        complement(9185..10237)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg25_131_Aminotran_1_2.1"
                     /evalue="3.60E-72"
                     /label="ctg25_131_Aminotran_1_2.1"
                     /locus_tag="ctg25_131"
                     /protein_end="387"
                     /protein_start="36"
                     /score="235.2"
                     /tool="antismash"
                     /translation="IIKLTLGEPDFNVPNTMKQAAIDSINANDSHYAPGNGTLALRQAI
                     AHFMQDRYQLDYDPENEIAVTVGATEGIFASLSTTINPGDEIIIPTPTFPFYIAVTKIL
                     GGIPIEVDTSSDDFVLTPARLQSILEEHPNAKGLILNYPSNPTGVTYTQDQIKALADTV
                     KSTSLIVIADEIYSELVYGATHTSIANYIPEQTLILNGASKSHAMTGYRIGFIAGPQEL
                     MKSVSAIHAMLVTAASNPAMAAAGAAFGTDEGKTATQEMKEAYKQRRDFVVNSLQKLGF
                     ELINPQGAFYVFAKIPEQYGNDDLKFATNLANEGKVAVIPGSFFGAGGQGYVRISYATS
                     MENLTGALDNI"
     CDS             10849..11070
                     /locus_tag="ctg25_132"
                     /transl_table=11
                     /translation="MRIDIKHYLEVNHLTIYQVSKRSGYGYTTLHKSFNKPQSSSTSLN
                     LRDLDALARAQDKSMWEVLKELEEHYLE"
ORIGIN
        1 ggcggacagt aagccgaaag acaacccaag ctgcatcaac tcaacaacct gtaacagtgg
       61 aagatgggat gaactttagc taccgggctg cgcaaaaagc gggcgtgatt gataataata
      121 catctgttga agagttttac aaaaatgcca aggaaggtaa tggttctgta acctacaagg
      181 gtcaaactgt ttactataaa gcaaatggta atggtcaata tcaagttaca accgctaaat
      241 agtttggtta ttaaaaagtg tccggtattt ttgccagacg cttttttagt aaaatactat
      301 gaaaaatgta aaatatacta attgtttacg ctttagtata taatgaatga gcgtaatgaa
      361 tatgtttaca aaatgatcat taagtataga aattatactt aactatttgg atgttattgg
      421 agtactttta tgcaaaaact atctattaaa caactaataa taatcacatt gtgcttatta
      481 gtgctggtgg ttggctgcat gactattcac cagcgtcgtc attttaataa gaacgttaag
      541 attgataatg tgtcggttgg tggattgact gctaagcaag cattaaagaa gttacaagat
      601 aatccacaat cgccaaaaat ttatgttaac aatgagttag tatttacgga taagcaatca
      661 gtagcaaagt ttagtagtgc tgacgaacaa aaaattgaaa atgcattaca tagtcagtat
      721 actttcttcc catcatctaa ggcaaagaac attgcgatta agcctcaaaa tgttaatcaa
      781 gatgaagtat caaagattga tcaagcagtc agtcaaaagg taacagaatt aaataatggt
      841 cgaaaagctc ctgttgatgc ttacgctgta tacgaaaatg gccgagtaca agtaaaacca
      901 gcagttggtg ggactcaata tagtttggat ggtttgcata ataagcttga aaaagaagtt
      961 gctggtggaa cagttcgtct gaagccaaaa tatacggctc cgctttctgc aaatagtaaa
     1021 actgttcaga atgaaaaagc aaagctcgaa gaattatcaa aacgaactgt aacataccaa
     1081 gtacaaaaca aaaagtatca gttaaattgt ggtgagatta ttaccagagc aacatatcaa
     1141 aatggaaaat atcactttga cactggagca gctaattcaa agattgatga aattaataat
     1201 acccaagcaa cccttggcaa atcatttgaa ttcaaaacac atgatggatc agtgatcaaa
     1261 acaacggctg ctggctcgta tggttggaag atcagtaaaa aacaagctgg aaagactctt
     1321 acgaatgcat tggttgcaaa taagcaaaca gtaaacgcca aaaatgatat ttatggtaag
     1381 ggttataatc aacaaggaac tgggtataat actacaagca acaatggtat aggggacact
     1441 tacgccgaag tttcactagc cgaccaacat gcgtggttct ataagaatgg taaatgtgtt
     1501 cttagcactg acattgttag tgggaccaat aacaaagata atgagacgcc aaaaggcgtc
     1561 tggtatatca tgtaccagca aacaccgtct gttcttcggg gccttaatga tgatggttcg
     1621 aaatacgcta gcaaagttca atattggtca ccatttactg atagtggatg tggatttcat
     1681 gatgcaagtt ggcgtcacga ttggtcaaaa caggcttatc ttgctaaagg cggtggatcg
     1741 cacggttgta ttaacatgca tccagacgta gctggtcaag cttttagtga cttacataaa
     1801 aatgagcctg tggttatcta ctaaaggagg agatgttgtg cgcccgagtg ctgaacgcgc
     1861 aattatgatt gcaatagctt gctttgtttt aacgattatt atttcttttg cattatcaga
     1921 gggatggata aagtaggagt tagttatatg gtggatttgg atttagaaac gaagaaaaat
     1981 ttggtaatca ttaacctttt ttatatcgga ttgattgcct tgtattgtat tttgcatgca
     2041 gggccactga attttttagt gtttttggga atgttagtga ttgcaaatgt agcagagatt
     2101 cttattggat agaggaggga caggcaatat ggtgcgtagt aagtataaaa tactgtcaaa
     2161 aactttttta gtaaaaattt atggtggacg tagccataga tttaatagag attggagata
     2221 tcttttcccc tattggaata aaagatgatc aaattaacta tatttcaagc ttttatcaat
     2281 agtttttcta acatctttga aataataatt atttatcgtt taatgataag tagtccagtt
     2341 ggaaaatcta tattacatga tatattatgg agtttaatta taattagtat tccattaata
     2401 acaattggat ctattaactt agtatttttg gtaatttact tatttttatt cgatcaaata
     2461 agatcaaata aaaataaggt tatggatagt attctagcaa tgtttacggc agttataatg
     2521 tcatcattgt ttgatctagt tgatcactat actcatactt tgcttttgca aaaaaaatca
     2581 gacttatcat tatggggatg gttaattccc cttaatgact ttttgacgac ccttctaatc
     2641 ggaatccttg ttgtaaaaat aattcgtcct cgtattagtt ggttaatgac tagtctttca
     2701 aggccaactt ggttatggag gataacagca atattattta tgttatatat ctggttgacg
     2761 gcaattatgg aaaaaaatgg aattgctaat agatacgctt ctatgttact aatagtatat
     2821 ttcatcatta ttattgtgag tgcgattggc tttattgact ttatgcgtac aagcaagcga
     2881 gctcagcagc aacaacaaat cattgataaa taccaagcac agattaccaa tgccaatcag
     2941 atgaaccaac aatacaatga aattcgacgg gaacgacatg atctacgaaa tatgctcctc
     3001 agtattcaag gttatattcg tgaccataag gataaagaag ccgaaaagtt gctgtcaaca
     3061 tttttgcaaa acgatacaac cgaaaagcac tatgatgaag tcgacttggc cttagataaa
     3121 atcaaaatct ctggcttaca taatcttatt aaggaaaagg cttataaaat agtagaaaaa
     3181 ggtattccat tttcgtttga agttaatgct gagatcgaca agttaccagg ttccgaaata
     3241 aaaactgcta gaatcatcgg aattttaatg gataatgcaa ttgaagcaac ctttaagcaa
     3301 actaaacctt atattcagtt tgcattgctt aagcacagcc caaaagttta tgaattggta
     3361 attgctaatt caattgagca aaaacttaat attaatactg cactaaaatt tgaacattcg
     3421 actaaagaag ggcatcaagg aattggcctt tcaaatgtga cacagttggt agaaaatgat
     3481 gaccattatt ctttttcagc ggaagttaaa gataaggtag ttatgatgac ttgttttatt
     3541 cagagaaagt gagaataaaa tgttaaaagt aattattttg gaaaatgatg attatcaagc
     3601 tgattatact gagcgcctag tttctcagcg aaaattgatt aatgctactc caaatagtta
     3661 tgacatcgaa ttatatttgc ggacaaatga tccgcaaaaa gtgattgata gtatcaaaga
     3721 tgaggcttat ttagcgattt tagatattga actagataat caacttagtg ggattgatgt
     3781 tgcggagcag atccgcaaaa aagctgaatt tgccgaaatt atctttgtaa ctgcttatca
     3841 agaatattta ccttatactg tttcgcgccg aattgagcca tttgattata tatcaaaggg
     3901 taagcagatt gagtcaattg cggatcgtct ccggattgat attgatgaag catatgctcg
     3961 ctatcagaat tacatgaata gtaatcaaaa acatcaagaa aagtttactt atgaaccgac
     4021 tcatggagta aaaaggcaag ttgattttga aaatctctat tatattgaat cagtaaaaaa
     4081 cacaaatcga cggttacgga ttgtgggaaa agatattcgg attgaatatc gtggcgagtt
     4141 aggtcaaatt aataacaagc atttattgaa agtgaatcaa agtacgctga ttaatcccaa
     4201 agcaatccaa gaatttaatc gtaaagaacg tgtggtttac tttgatgaaa atcaggaaat
     4261 taagataact gttagttacc gaaaaataaa atcattaatc aattttcttg aaaaggaaaa
     4321 tcactaacta ttttattttc aaagaaactg tgacaaaaag ctgtcgtggt ttcttttttt
     4381 gtcaaacaat tttagtaaac gttttcaaga attttactac gaattctgca gaaaggctta
     4441 cgaattttgc aaaatgacac agagaaaatt tttacttata tactaagggt gggatcaagg
     4501 taaagtatta tgcattggaa cataatgtta aaatcctaac tttatcgtat caggaggtaa
     4561 ttaaaatgac ttatcgtaaa ttaaacttcg atgaattaag caaggtttct ggtggatgga
     4621 gtctctcttc acaggttaat gaactagtta aagatgttgt taattccttg aacaaatggg
     4681 ctcaatcttg ctacgcaggc tataaagata gtccatttca ctaataagag gagaagatgg
     4741 taaaagtgag aattaataaa caattttaca aagattttaa tttttatttt tacatgttat
     4801 ttattgttct ttggattaaa ccgttaatag atgcagaaaa tggttatgaa cttacttact
     4861 gcttagtttt cttagttgga gcaataattg ctactttatt aaccatattt aaaaataaat
     4921 agtatcttat gagaatataa agcccagaat aattattaat tttggacttt atttctttgt
     4981 ctaattagaa agcgaggtga atgaaaatca attatcctca ttatgtagct caagttgatg
     5041 aggcagattg cggagtcgcc gctttagcaa tgattttgca caattttggg tctgtttatc
     5101 caatcgcaaa attacgtgac ttagcacgga caactaagca aggaactacc gccttaggac
     5161 ttgtaaaagc agcaaaacat cttggattag acgttacccc cattcaagca gatatatcat
     5221 tgtttaatga tcctgaaatt acttacccgt taatcgcaca tgtgattaag gatgatttac
     5281 ttcattactg tgtcgttttt aaggctgacc aagattacat ctatgtagct gatccagatc
     5341 ctgctacgaa agtacaaaaa atgactcggg atgagtttgg tcgtttatgg tcaggtgtaa
     5401 gtttactttt ttcgcctgct aaggggtata caccgcaaaa agaaccttta gctgggttaa
     5461 tgacgatgtt tcgacaatta actaattata aaaaagatat atcaggaatt atcattgcgg
     5521 cattattaat taccctcatc agcatcgttg gatcatacta tctccaatta attattgatc
     5581 gttttattcc ctcgaaaaat attgatggct tagcgatcct tgctggtagt ttattggtag
     5641 tctatgtgtt caactctctt tttaactatt tacgagatgt tctcttgact aggttggatc
     5701 aaaaactaac atcacaaata agtcttagat atattcacca tgtttatcgt ttaccgatga
     5761 gatttttctc tacaagaaaa acgggggaaa ttacttcacg gttcaatgac attaataaga
     5821 ttattgatgc cttatcaagc actattattt caatgttctt agacgttggc gtgatggtga
     5881 ttataggaat tgttctttct ttgtacgatc ggtcattatt tttaactaca attagtacca
     5941 ttccgattta tgtcattatc atttatgcct ttaataagcg ctttgctaaa ctggatcaag
     6001 aacaaatgga gagtaacgct caattaagtt cagcaattat tgaggattta aaaggcgtag
     6061 agacgttgaa agtgctgcaa cttgaaaata tccgttataa aaatgttgaa aaacaatttg
     6121 cggatttctt acgaaagaat ctaacatatg ttaaaactaa atcttttcag gatgcaatta
     6181 aaatgtggat tcaatacggc ttagtaacaa tcattctttt tcaaggagca gttttagtaa
     6241 ttcagggtcg cttaagtatc gggacattga tggcctttaa tgcgttatta gcctttttta
     6301 tcagtccatt acaaaatatt attaatcttc aacctaaact ccaagaagct aaagtggcga
     6361 ataatcgatt aaatgaagtg ctgcaagttg acaccgaaaa ggcagatacg aattctcagg
     6421 atcaagtaga tttggtaggt ccgataaaca ttcaccatgt tgactattca tatgaatata
     6481 gtcgtccaat tttacaggat atcaatcttc aaattggttg taatgataaa ttgacaattg
     6541 taggattgag cggttctggt aaatcgacct tggcaaagtt attagttggc ttttatttac
     6601 ctactcaagg acagatagaa tttaatcagc ataaaacaac tgagattaat ctttgcgata
     6661 ttagacaata tgtacattac ttaccccaat tgccacaatt attttcggga acaatcaaag
     6721 ataacttgct aatgggatta gaccgggaag tatcagctga agaaatcgat aatgcatgta
     6781 aattggcatt aatctataat gatattcaag aaatgcccct aaaatatgaa acaaaactag
     6841 atgaagaagc aactgcatta tctggtggtc aaaaacaacg cttgacgatt gcacgggcac
     6901 tcctaacttc tgcgcgtgtt ttaatttttg atgaatcaac aagtagtttg gatccaatta
     6961 ctgaaaaaag aatcgttgag aatttgcttg agattgaaga ccgcacaatg atttttattg
     7021 cccaccgtct ttcaattgct aaaaaggtca acaaagtagt agtaatgcgc gacggaaaaa
     7081 tcattgaaca gggtactcac caagaacttt tgaattatca tcaagaatac tataatttgt
     7141 ggaatgcata agggagcgag acagaagtca cttgtgactt cgtttttcga cgcgaagcta
     7201 gcctctggga gcccccgcaa gcaacaatag gcctctaacg ttcggttttg ccggatgtta
     7261 gaggccattg ttgtactgcg tatttgcttt ttatgaaagt aacttaactt atgtcacagt
     7321 cctttctcag tctttattaa acataattgc gagcatggaa ccgatagtaa aaattataaa
     7381 gaagatacat agtagcgact catctaatgg aagcgaacca tctgaaaatg gagcaatcca
     7441 gagaaacaaa agtaataagt acacataaaa gaaaccatcc cgccaaaagt ccttattgaa
     7501 gtgaattttc attagttctc cccctaagac agtatgtgta ccttaattat aaggaaagat
     7561 ctaatttaaa ggacactttg caaaattcgt taagtttctt gcagaattcg tataggttga
     7621 ctatttagaa aaacgccctg gaaaattcca aggcgttttt tcaactaatc aacttttaca
     7681 aatccatctt gaacaaattt cgttccgtag gtcagagtgt tttccacggg acactttgcg
     7741 gcaacgtcag cgaggaactt cttgatgtct tcatcagact cgctgctgcg aaggtgtggt
     7801 tggtaacgga tctcagtaaa tttacgaaca ttcttaccat cagcaacatc ttcacgacca
     7861 agatcaccct cgattgttac ccaaaaagct cgtaggtcaa agttgcgttt tttagctaat
     7921 gcttgggcag tgattgcctg gcaggcacca aatgatgcga ggagaatttc tactgggttc
     7981 atccccgtat ttgtactttc aggttcatca aaggtgattt caaaaccgcg ggtacctgct
     8041 gaaacctgca ttcccgttgt tgtcttagtc gctgttactt tatatttact catacccgtt
     8101 ccctccttta atacccatag tgtaatcgag acgatacttt tggtcaatga gggtgctcaa
     8161 ttataaggtg atttcatgtg gtgattttcc ttcattaagg attgtcatta catcattaag
     8221 agaaatatct accatgtttt tgacagctaa attagtaaag aaagcgatat gaggagtaag
     8281 aataacatta tccatttcgt gaagttcttt aacaagtggc tggtcatcaa gccctttttc
     8341 tcgacgatct gtagctgcca ccgtttcttc accctcaaaa gtatcaaggg cagccgctgc
     8401 aattgttcct tttttaaggg ccgcaactaa atcagctgta ttaacgactg gaccacggct
     8461 agcattaacc aaaccggcag ttggtttcat cattgcaaag tcgttagcag tcagtaaccc
     8521 tttggaagtc ggatttaaat cgacatggag gctgacaaca tcggcttgtt ttagtagctc
     8581 ttctttagaa acaaactgga caatgccatc gaggtcagtg cgcggattcg tatcatatcc
     8641 taaaacggta gcacctaatg catgaaggag ttttgctaga gttccgccaa tgcgtccaac
     8701 accaataatc ccaacggtag cagtatgaat ttccgttgat tgttcatcgc taaaccagcg
     8761 gaagtcattt tcggcgactt gatggtcaaa gcggtaagtt ttccgaagta accggaatat
     8821 ctgcattaat gcaaactcag cgacacttcg cggtgaatat gctgggacat tggtcacgac
     8881 tagaccattt tcattagcct ttttgacgtc gaccatgtca aaaccagctg tccgggtcgc
     8941 aatctgtttg agaccattag catgtagttt ttcataaata gtagccggaa ctttactacg
     9001 ttgctgaatc acgagtccat caacaccggc agttaattca acagcatcgt caatcaattt
     9061 cggcgttgtg atgatttcga tattatgttc ttttgcgtat tcgttaatgg cggtttgttc
     9121 atcgtcccgc acacttgtca ttaagatttt tgtcatgtta atcctcctta ttaatgaagg
     9181 ccgcaatgtt atcaagagct ccggttagat tttccatact ggttgcgtaa ctaattcgaa
     9241 catatccttg gccaccagct ccaaagaaag aaccaggaat cacagcaact tttccttcat
     9301 tggcaagatt tgtcgcaaat ttaaggtcat cattaccata ttgttcagga atcttggcaa
     9361 aaacgtagaa ggctccttga ggattaatca gctcgaaccc taatttttgg aggctattaa
     9421 caacgaaatc tcgtcgttgc ttataggctt ctttcatttc ttgagtagct gtttttcctt
     9481 cgtcagtacc aaatgcggct cctgcagcgg ccattgctgg attagaagca gccgttacta
     9541 acatcgcgtg aatggcactg actgatttca tcaattcttg tggcccagcg ataaaaccaa
     9601 tccggtaacc agtcattgca tgtgactttg aggcaccatt taaaattagc gtttgttcgg
     9661 ggatgtaatt agcgattgaa gtatgagtag ctccgtaaac aagttcagag taaatttcat
     9721 ctgcaattac aatcaagcta gttgatttaa ccgtatcggc gagtgcttta atttgatctt
     9781 gggtataagt aacaccagtt gggttagaag ggtagttaag aattagtccc tttgcgttag
     9841 gatgttcttc tagtatgctt tggagtcttg cgggtgtgag aacaaaatca tcgctgcttg
     9901 tatcaacttc aattgggatc ccaccaagaa tctttgtgac agctatatag aaggggaaag
     9961 ttggggttgg aatgataatt tcgtcgccag gattaatagt agtagaaaga gaagcgaaaa
    10021 tcccttctgt tgcgccaact gtaaccgcaa tttcattttc cggatcgtag tccagctggt
    10081 aacgatcttg catgaagtgg gcgattgctt ggcgtagtgc taaggttcca tttcccggag
    10141 catagtgtga atcattggca ttgatactat cgattgcggc ctgcttcatt gtgtttggca
    10201 cattaaagtc tggttcacct aatgttagct taatgatgcc agggattgta ctgacttggt
    10261 agtcaaattc gcggatcccg ccaggagtga gtttagcgaa attattgtta agacgactaa
    10321 gaatttcttt tttagtagct ggcatgataa tttcctccta tataatatgt aaatttagaa
    10381 aaagaagccc taaatgctat cggaataaca tccagggctt cttgatcaga ttggaatgag
    10441 tataaaagag gctctcggat gtttgggggt catccgagaa cgccacaatg acaaaatcac
    10501 tgctggttag cggacggtaa tcgcgctaaa ccagaagaca tacgcttgat tcaagtgaat
    10561 tgtcgcagtg atcatcattg tgtcctcctt ttgattaact gattattaat aattctaatt
    10621 gttttttaat ttttgtcaag cggtgtttga aaaaaactat taattacaaa attatttatt
    10681 ggttacaaat gtaaatataa caaagagcga aaatgtttgt gattattagt tcgcctttaa
    10741 tttaatatta aatttatatc ctacaatttt tttaattttt ttgtgtcttt tttgttgtct
    10801 tactacacaa atgtgatata atattaatcg taaaggaagt gggtagcaat gcggatcgac
    10861 atcaaacatt atttggaagt taaccacttg accatttatc aagtttccaa gcgttccggt
    10921 tacggctaca cgactttaca caaatcgttt aacaaaccac agtctagttc gacgtcgctt
    10981 aacctgcgtg atcttgacgc cttggctcgc gctcaggaca agagcatgtg ggaggtcctt
    11041 aaagaactag aagagcatta cctcgaatga gattgtggtt ttgctgtagc cacaggaagt
    11101 caagtgtgtt aacttttggc tttcagaata cttagactac gaaacttaga aaataaaata
    11161 ttatatttaa ttgaggaggg attgcatatg gctcaaaacc caatgaatcc atttgacaac
    11221 gacatgaatg acatctttaa tcaattaatg ggtggcatga atggtttcaa ttctgataat
    11281 cggcgttacc taatcaatgg tcgtgaagta acaccagaag aatttgctga atatcgtaga
    11341 actggtcaat tgccaggcgg tgcaaatcct caacaaggtg gtcaacctgg ccctcaacct
    11401 aacgcaggta aggacagtat cttacacaag ttaggtcgga atttaactca agaagctcgt
    11461 gaacatgaac ttgaccctgt tattggtcgt aacaaggaaa tccaagaaac agctgaaatt
    11521 ttaagccggc ggacaaagaa caaccctgta ttagttgggg acgctggtgt tggtaagact
    11581 gctgttgttg aaggattagc acaagcaatt gtttccggcg atgtgccagc tgctatcaag
    11641 gacaaggaaa ttatcagtat tgatatttct ggtcttgaag caggtaccca ataccgtggt
    11701 agctttgaag aaaacatgca aaagttggtt gatgaagtca agaaggctgg aaacattatt
    11761 ctcttcttcg atgaaattca ccaaattatc ggtgccggtt caactggtga ttctagtggt
    11821 tctaaaggta tgtctgacat tattaagcca gcattatccc gtggtgaact aacagttatc
    11881 ggtgcaacta ctcaagatga ataccgaaac actattatga aggatgctgc attagcacgg
    11941 cggttcaatt ctgttactgt taatgctcca agtaaggctg atacagtggc catccttaaa
    12001 ggtattcgtg acttgtacga acgtcaccac aatgtaaagt taccagatga cgttctccaa
    12061 gctgctgttg attactctgt tcaatacatg ccacaacgcg cattacctga caaggctatc
    12121 gacttaatcg atatgaccgc tgctcactta g
//
