LOCUS       c00022_JAJGUR0..       15167 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJGUR010000121.1 Limosilactobacillus reuteri strain LTM_Jesus_5_1
            scaffold121, whole genome shotgun sequence.
ACCESSION   JAJGUR010000121
VERSION     JAJGUR010000121
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 15:40:27
            Original ID  :: JAJGUR010000121.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 13167
            Orig. end    :: 28334
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15167
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[18167:23334]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..10167
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..15167
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15167
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(377..1021)
                     /locus_tag="ctg22_18"
                     /transl_table=11
                     /translation="MAALCGGIIGFERKSKAKMAGIRTHALIAVGAAMVMIISKYGFFD
                     LLKVTHSNWNVDPSRIAAQVVSGIGFLGAGTIINRHDEIIDGLTTAAGIWVTGAIGLAY
                     GSGLYSIGIIGTCCVLLAEVIGKYLDQFALRQGKGFSCFIQLEGNTDDLHALITQLNKK
                     YFEVPLKYSIYDYGDGKISCQLYGELRSGFKSENVFTDLTELGNIKKVELE"
     CDS             complement(1185..1721)
                     /locus_tag="ctg22_19"
                     /transl_table=11
                     /translation="MNNDVEKVLYTQDQVNQRLDELANTLTEKYQDEFPVLVSVMTGAM
                     IFTSEMMKRLNFKLNVDYVDVSSYEESSESTGKVKLIQDLSHDIKDRPVIIMEDIIDTG
                     HTLKYLADLFADRGAKSIEICSLLDKPDRREVDVEADYVGFKVPNEFIVGYGLDFNGLY
                     RNLPFVGVLKRSVYE"
     CDS             1862..2956
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 116.3; E-value: 2.7e-35)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_20"
                     /transl_table=11
                     /translation="MRHKICIIQVDIFLNGCLEGILIIMKKVNLYIFLTLCSFAIFLLT
                     TPSKVKAEVVDKQTQHQLQDYMKDHHINGVMLVNGKDGKPVAIENNETTNKDQIVKADR
                     LFPTASLQKIVTGTAVYQLKQKKQLDWDTSLSKYYPQIDGSKDITIRELMNHTSGLINN
                     DRPFEPLRGQKAQIAYMLKHLKYDHTHTWDYQDVDYEILAAIVSKQAHLSYNAYIQKNF
                     AKPLHLHQIKDFSEVSKKEIPQPMDPTVDWHRVTVTTSSDFGAGNLFISPNDYWKFVYN
                     EVLKDPKMINEYYQQAQHQEVAYFGGVYFDGDVIRANGSIPGYNSCFVADYKTKRMIML
                     FSNNIDYLKLKATSDDILHNYMEH"
     CDS             complement(3025..3351)
                     /locus_tag="ctg22_21"
                     /transl_table=11
                     /translation="MSFTMNLYYTGEGDNAKKFAQEMEERGIADQIRQQPGNLKYEYFQ
                     PLDDPHTILLIDTWESQEALDADHDSPMMAELAKLREKYNLHMRAERFIPEKLPDKDNK
                     FLRK"
     CDS             complement(3375..3869)
                     /locus_tag="ctg22_22"
                     /transl_table=11
                     /translation="MTLGTYQQVKDALKKFGITDYTVIDHPAAHTTEEADAYIAGHEGV
                     RTKTMFLKGKKKNFYMVIMDDKKPMDFHEFMALTGAKRVSMARPEYLQEQLGLAPGIVS
                     PFGLLNNEAHNVKVYFDKDIVNEPIQTFHPNENTHTIFIKTDDLFKFLKQIDFEPEIID
                     L"
     CDS             4113..4373
                     /locus_tag="ctg22_23"
                     /transl_table=11
                     /translation="MSSKVQVNIDPELKQSAENIIKEIGLTPTAVINGMYKQIVATGKI
                     PLSFSLTSRQRAELELREVSKKIPVREVKTKEELEEFFNED"
     CDS             4363..4683
                     /locus_tag="ctg22_24"
                     /transl_table=11
                     /translation="MRTNQIYTAYVSWGSDGKRRPVLIVENKNVFCYRITSKYKNKSER
                     IKKNYFPLMDWKIEGLDKQSYIDVGDIIKLSKEHVSFRLVGELSIRDIEALVEFIRNRY
                     EI"
     CDS             complement(5001..7160)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 279.6; E-value:
                     8.5e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_25"
                     /sec_met_domain="TIGR01193 (E-value: 1.6e-289, bitscore:
                     954.2, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 7e-39, bitscore:
                     124.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYNFRRHYINQVDEADCGVAALAMILHNYGSKISLATLRKFTKTT
                     TDGTTALGIVKAAEKLKMDVEAYQADASLFDSKDVIYPFIAHLIKKDSGLLHYCVVFKS
                     SKKHIFIADPDPNIQVKRIPKVNFFEEWTGIAIFAKPGKNYKPIQEKIPTFKRLCRPLF
                     QQKALLFGIITAAFIVTFLNILNSYYLQTLLDILIPNKLQDPLAIISIGLLFAYLFNSL
                     FTFSRDYLLAILGQKLSKIIILNYIKHVLRLPMAFFSTRKTGDILSRFTDANKVIDALV
                     SAIISIFLDATILIIIGTVLALQDIRLFGITMLIIPIYSLIIFSFTSNFRKLNQKEMES
                     NATVSASIIEDIRGIETIKSLNCEEVRSDKITNEFNDFLHKSLVHTRLNNIQQGLKTFV
                     QLSLNLIILWVGANQVIKNELSIGQLMTYNALLVYFTTSLQNIINLQPKIQSAQVANNR
                     LNEIYMVKDEFKNTTKHNHSLKNGTIELKNVSYSYEYNSPILQNINLKIKSGEKLTIVG
                     LSGSGKSTLMKLLVNYFDVSNGEILINNLNILNISKKQLRSFINYVPQIPYTFSGTIKE
                     NLLLGNRTTITEKDIVTACKTAMIHDDIMHLPLGYNSKLDENATTFSGGQKQRLTIARA
                     LLSSAKVLIFDESTSGLDVLTEEKLIKNLMALSSKTIIFIAHRLSIARITNNITVIDNG
                     KIVEQGSHKELLKNKSLYFKLMQTQ"
     CDS             complement(7172..7945)
                     /locus_tag="ctg22_26"
                     /transl_table=11
                     /translation="MDYHLLVCDDDRTQAKNIATLLKMSSIILEEQDIHPTIDLIATDA
                     ESVLDYLEFNSDLNNIIAFLDIQLDENSSSKGGLDLAQKIKTLNEKAQIIFITTHEELA
                     FLTFQRRINPLDYITKTTNQRDLQRRLTETLELAIRKLNEFNYIKKNTFSYKVGTRIIN
                     VNFSNILYISTTKFPHKLKIVTSNGQGEFSGDIKTIEQNYPLFFKASQSSLINLQNVET
                     INTKKRLIKFSNNDCLNYSRSRAKELNNLYKNLTC"
     CDS             complement(7958..9220)
                     /locus_tag="ctg22_27"
                     /transl_table=11
                     /translation="MNILIQIISVIQALTFELLIFLYLIKIKVTKRDTFRLTIIFTILF
                     LMIGLGYIGAYLSTILEGGFLYFYFKNRTPKPKLIGAILLTLTTSILTDFSTFTIDKVL
                     SLPTSYILFIDPIFYLFIFILFYHYHPLDKIEDKNATINLWILFYLFITLNIAGFIIFT
                     TPRVTPAFIVIFCLLVLQCSFTVFIYRISRQIQQKKLQLQEKKDLLFLIQNLEENQSKL
                     RRFKHDYQNLLNSLKLSAIHGDNQALLDKLENYSRDNLGKDSLWQFQDTKNIKDDVLRS
                     IFISKLNSIYQKDIKYHFECLTEINDLPNIDLFDLIRIIGIAYDNALEECETLKKLGAR
                     TVEINSMLYQSAPNKLEFEIKNTCRKQLSTNKLHQEGITNKANHEGLGLATVKKIANKY
                     HNVYIAYSSDNGYFTFTISIE"
     CDS             complement(9233..9370)
                     /locus_tag="ctg22_28"
                     /transl_table=11
                     /translation="MKKLSTQQLSLIKGGYGYALTFKSVNNNTYTYTNKIISSLRHIFH
                     "
     CDS             9739..9945
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_29"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.5e-16,
                     bitscore: 51.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLEDFQLKQILGGKNSWQQNVYGSVGAAAAGAGLGAAICGPAC
                     GFVGAHYGAIAWAGVTGATHGFH"
     CDS             9979..10167
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_30"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2e-11, bitscore:
                     36.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQQLKNEQLEFILGGNRWGNATIGAMSGAARGVKWCRPAGAWGMA
                     GCAVVGAGVGGYFGYHS"
     CDS             10187..10489
                     /locus_tag="ctg22_31"
                     /transl_table=11
                     /translation="MKKIIKNNKWNIIAILIFFGLCIYYVYDKNIVMASDSLLGAIIWL
                     ISCLNKKYSYLAGIALISYAVFILIIRADLWPGAVACIVIGLFILFFYLKKLKKQ"
     CDS             complement(10703..11380)
                     /locus_tag="ctg22_32"
                     /transl_table=11
                     /translation="MNKPYIIVHMMTSVDGRIDCGMTAQLAGEPEYYSTLDSLNVPTRI
                     SGRVTAETELTRDGKFNPQNKEILGKTDFAKNATADNYNIVVDTKGTLQWGTENGNNFP
                     HLIITSEQVTKDYLDYLNRQNISWIATGKDQIDLAKAMEILADKFNIDRLAIVGGGKIN
                     GGFLEAGLIDEISILIGTGVDGRTGQPSLFDGRPESSRPIALQLKDVASFDDGAVWLRY
                     LVK"
     CDS             complement(11482..12411)
                     /locus_tag="ctg22_33"
                     /transl_table=11
                     /translation="MSIGQIFNQVVIIFLLMLLGAVIRKLGFLHPQSINDLTNITLYFL
                     SPIVIIKAFEQPFSRSRFYQLLLLIAGVFLTYFVSILIAKLLFHKVKDQNIRQIATYGS
                     IYSNNGFMGVPLAQGLFGSVGVFYAVASMIGFNVMSWTQGIGIFQKRQPHDWGTQLKKI
                     ILNPNIIAIIIGLFLFISSFRLPKLISGFIDYTSPAFTPLSMIVIGSNLANLSIKNIKL
                     PTTLWGSLFVRNIFFPILGTIILLLLGITGVPLFTTVILSACPVAGLVVLFTLQSNGDA
                     RPATVLMSISTILSLVTIPLVYWFASLW"
     CDS             12553..13239
                     /locus_tag="ctg22_34"
                     /transl_table=11
                     /translation="MSTLLVIQAHPHIENSLSLTVGKQFVDTYKETHPNDQVIIRDLYT
                     KEGVPPLNDVTMEAWRKQKFDEPMTEEEKDLLKRHEEWLDEFISADKYVFINPMYNHFL
                     PAEMKQYLDLTAVAHKTFKYTSNGPVGLLTGKKAIHIQAAGSEYHKSGKWGTVKFLIKK
                     AFGIKSKESSALMDLGDMYLTNMLKFYGITDVEKLFIEGADAHRDQRQKILNDALAEAK
                     SMAKVF"
     CDS             13276..13770
                     /locus_tag="ctg22_35"
                     /transl_table=11
                     /translation="MNKVNEKTINKIRHTIELLRVQHSNIHGSQEQQWIQEHLTDKKLK
                     QEVLNLSIVAFHILSVLESGEQTGIEIAEKINVTRGGVTRAAKKLLQYDLILATKHSDD
                     KKKIYYSLTDEGKKLAKVHDQMHETIKRELVDKLTAKYSMDDLKIVANFLNDLYRLEQK
                     F"
     CDS             13867..14547
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 210.6; E-value: 3.7e-64)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg22_36"
                     /transl_table=11
                     /translation="MKKAVIMLVEDEESLASFLITELELEGYEVIWTKDGREALDIFKE
                     KDITLILLDWMLPIYDGLTVLRRIRQSSNVPIIMITARSQTSDISMALDQGLDDYITKP
                     FEIEELLARIRVVLRRLGQEKAEKYDYKFGPFEINLLKHQFMVDGKQVHLTPKEFSLMV
                     ALIKEPGVVQTRDDLLNEIWGYDFDGQTNTVDVYIRALRNKLGKYCDLIKTVRGIGYVL
                     GDEQ"
ORIGIN
        1 ccagtcgaaa acgtcttgag taacaaagtt aggaagccga atcatcgcaa tgaaattgaa
       61 catttctttg tgagcatagt caattcccac aatgccatct tgccaccata gtccttctag
      121 tgggggaaca acaaaatcaa aataatctgg aatttggtag gtgccttttt tgctcatttt
      181 tatggtataa gcaacagcgt aaagcttttc aattgctttt ttatactcac tattttcctg
      241 attaggatcc ccatgtcccc gtacagcaag atacttcatc actggtacat tgattaagct
      301 aggactcttt ccggggacat acaattcttt ctgctctttt ctaaaattat aagccatctt
      361 gtcacttcct atgtttttat tctagctcaa cttttttaat gttgcctagc tcagtaagat
      421 cagtaaagac gttttctgat ttgaagccag atcttaattc accataaagt tgacaggaaa
      481 tttttccgtc tccataatca tagatcgagt atttgagcgg aacttcaaaa tattttttgt
      541 ttaactgagt aataagcgca tgcaaatcat cagtatttcc ttctaattga ataaaacagg
      601 agaatccttt accttgtctg agtgcaaact gatctagata ttttccgata acttctgcta
      661 aaagaacgca acaggtgccg ataatcccaa tgctgtataa accactacca taggcaagac
      721 cgattgcgcc ggtaacccaa attccagctg ccgtagttaa accatcgatt atttcatcgt
      781 ggcgattaat gattgtccca gcgcctaaaa aaccaatccc gctaacaact tgagcggcaa
      841 tccgtgatgg gtcgacgttc caattgctat gggtaacttt cagtaaatca aaaaagccat
      901 acttagaaat aatcatgacc attgctgccc ccaccgcaat caaggcatgg gtccgaattc
      961 ccgccatttt agccttactt tttcgctcaa acccaatgat tccaccgcac aaggcagcca
     1021 tgagcatccg taaacaccag tcaagcctaa gcaacgatta cccctccttt accaaaaatc
     1081 aattattatc aattttatta gcctaactgt actatatcgc gtttagatgt ttaaagccaa
     1141 aaagaaagct gaaagaaata acattttctc tcagctttta actattattc atatacggaa
     1201 cgctttagca cacccacgaa tggaagatta cggtaaagtc cattaaagtc taagccgtat
     1261 ccgacaataa attcatttgg tactttaaag ccaacgtaat cggcttcaac atcaacttca
     1321 cgacggtccg gcttatcgag taaggaacaa atctcaatac tcttagcgcc acgatcagcg
     1381 aaaagatcag cgagatactt taatgtatgg ccagtatcaa taatgtcttc cataataata
     1441 actggtcgat ccttaatatc gtgggaaaga tcttgaatta atttaacttt tccagtggat
     1501 tctgaacttt cttcataact agagacatcg acataatcaa cgtttagctt gaaattaagg
     1561 cgcttcatca tttcactagt gaaaatcatt gctcctgtca ttacagaaac taaaactgga
     1621 aattcatctt ggtatttttc agtaagggta ttggcaagtt catctaagcg ttggttgact
     1681 tgatcttgag tatataaaac tttttcgacg tcgttattca ttctagctct cccttgataa
     1741 tgttcgttat ttacgaacta tttttgcggt ttttatttat tgacgttaga attttaacat
     1801 aaatcgaatg aatttaaagt gttttagcaa gaaaaatcag atttttgttc tgctttgtaa
     1861 gatgaggcat aaaatttgta taatacaggt agatattttt ttaaacggat gcctggaagg
     1921 gatacttata attatgaaaa aagttaattt atatattttt ttgacgctct gttcctttgc
     1981 catcttctta ttgaccacgc catcaaaggt aaaggcagaa gtggttgaca agcaaacgca
     2041 acatcaactt caagattata tgaaggacca tcatatcaat ggggtgatgc tagttaatgg
     2101 caaagatggg aagccggttg ctattgagaa taatgaaacc acgaataagg atcaaatcgt
     2161 aaaggcagac cgactatttc ccacggcatc gcttcaaaag attgtaacgg gaaccgctgt
     2221 ctatcaatta aagcaaaaga agcaattaga ttgggacact tcgctaagta agtattatcc
     2281 gcagattgat ggtagtaaag atattacgat tcgggaatta atgaaccata ccagtggctt
     2341 gattaataat gatcgtccat ttgaaccact tagaggccaa aaagcccaaa ttgcttatat
     2401 gcttaaacat ctcaagtatg atcatacgca cacatgggat tatcaagatg ttgattatga
     2461 aatattggca gccattgtta gtaagcaagc acatttaagc tataatgcct atattcaaaa
     2521 aaactttgct aaaccgctcc atcttcacca aattaaagac ttttctgaag tttcaaaaaa
     2581 ggaaattcca caacctatgg atccaacagt tgattggcac cgggtaactg taacgacctc
     2641 ctcagacttt ggagcaggga acctatttat atcgccaaat gattactgga agtttgtata
     2701 taatgaggtg ctgaaagatc caaaaatgat taatgaatac taccaacagg cgcagcatca
     2761 agaagttgcc tattttggtg gagtctactt tgatggggac gttattcgcg caaatgggag
     2821 tattcctgga tataacagtt gctttgtcgc tgattacaag acgaaacgaa tgattatgct
     2881 attctctaat aatatcgatt atctaaaatt aaaggcaact tcggacgata ttcttcataa
     2941 ttatatggaa cactaaatcg ctaaataaaa attctctaag tttttactaa aggacttaga
     3001 gaattttttt gatgttatag ctgcttattt tcgcaagaat ttattatcct tatccggtaa
     3061 tttttctggg ataaagcgtt ctgcgcgcat gtgtaaatta tatttttcac gtaatttagc
     3121 taattccgcc atcatcggtg aatcatgatc agcgtctaat gcttcttgac tttcccaggt
     3181 gtcaattaaa agaatcgtat ggggatcatc aagtggttga aagtattcgt attttagatt
     3241 accaggttgt tgacgaattt gatccgcaat tccccgctct tccatttcct gggcaaactt
     3301 tttagcatta tcaccctcac cagtgtagta aagattcatt gtaaagctca taatgtcacc
     3361 tccttggtct ccaactatag gtcaataatt tctggttcaa aatcaatctg cttaagaaat
     3421 ttgaacaagt catctgtctt aataaaaatt gtatgagtat tttcgttagg atggaaagtc
     3481 tgaattggtt cattgacaat atccttgtca aaatatacct ttacattatg agcttcatta
     3541 ttcaggaggc caaatggtga aacaattcct ggtgctaagc caagctgttc ttgcagatat
     3601 tccggtcgag ccattgaaac ccttttagct ccagttaggg ccataaattc atgaaagtcc
     3661 attggttttt tatcatccat aataaccatg tagaaattct ttttcttccc tttcagaaac
     3721 atggttttag tgcgaacacc ttcatgacca gcgatatatg catcagcttc ttcggtggtg
     3781 tgagcagcag ggtgatcaat cacagtatag tcagttattc caaatttttt taatgcatcc
     3841 ttgacttgct gataggttcc taatgtcata attttgctcc ttaattaaat cttttgttgt
     3901 gaaacgctta cattaattat aaagcaaatt aagcaattag atgagccaat attttttctg
     3961 taaaacttgt ttcaattaat actagggatc gaacttaata tttttatgga agaaatttta
     4021 atcgaagctc ttgttactta gtaggaaatg tcataataac cattattatt tataattaca
     4081 acatgttatt atatgattat gaggtgatta taatgagttc gaaagttcaa gtaaacattg
     4141 atccagaatt aaaacagtca gcggagaata ttataaaaga aattggttta accccaacag
     4201 ctgtaataaa tggaatgtat aaacaaatag ttgccacagg gaaaatacct cttagttttt
     4261 ctttgacatc aagacaaagg gcggagttgg agttaagaga agtatccaag aaaattccag
     4321 ttcgtgaagt taagacaaaa gaggaacttg aggaattttt taatgaggac taatcaaatt
     4381 tatactgctt atgtatcttg gggttcagat gggaaaaggc gtccagtttt gatcgtagaa
     4441 aataaaaatg tcttttgcta tagaataaca agcaaataca aaaacaagtc tgagagaatt
     4501 aagaaaaatt attttcctct tatggattgg aaaatagagg gacttgataa gcagtcatat
     4561 attgatgtgg gagatattat taagctttca aaagaacatg tgtcttttag gcttgttgga
     4621 gaattgtcaa tacgtgatat tgaagcgctg gtagaattta ttcgcaatcg atatgagata
     4681 taaaaataaa aacgtcgcag aaaaattctg tggcgtttta ttaatgtctt tagacctagt
     4741 tgagtgcgtg agcagagcga atgcacgaaa caaaaaacca cctgctatgc gggtgggcga
     4801 taaaattaga tacaaaagcc tcttttgcct taagatgtag gtgttcaagc caaagtcaat
     4861 aagggaaaag aggtaataag aatatggtta ataattaaac aagttagcca tataaaaagt
     4921 atagatggaa aattatatga ctattgtata agctaagaat gcttaatcgt tatgcaaaat
     4981 tgaataaaga cagcctctat ttattgtgtt tgcataagtt taaaatataa cgatttattt
     5041 ttgagaagtt ctttatgaga accctgttca acaattttgc cattatcaat aactgtaata
     5101 ttatttgtaa ttcgagctat tgaaagacga tgggcaataa agatgatcgt ttttgaagat
     5161 aatgccatga gatttttgat tagtttctct tctgttaaaa catcaagtcc actagtagat
     5221 tcatcgaaaa tgagtacttt tgctgatgag agtaatgctc tcgctattgt aagccgctgc
     5281 ttctgccctc cagaaaaagt tgttgcattt tcatctaatt tactattata tcccaacggt
     5341 aaatgcatta tatcatcatg tatcatagcg gttttacatg cagttacaat atctttttca
     5401 gtaatcgtag tgcggtttcc taataataag ttttctttaa tcgttcctga aaatgtataa
     5461 ggaatttgtg gcacataatt aataaaagaa cgtaactgct ttttagagat atttaaaata
     5521 tttagattat taataagaat ttcaccattt gaaacatcaa aataatttac taataatttc
     5581 attaaggttg atttaccaga gccacttaga cccacgattg tcagtttttc gccagactta
     5641 atttttaagt taatattttg taatatagga gaattgtact cgtagctata agaaacattt
     5701 tttaactcga ttgttccatt ttttaatgaa tgattatgtt tagttgtatt tttaaattcg
     5761 tctttaacca tgtatatctc atttaaacga ttattagcaa cttgcgcact ttggattttg
     5821 ggttgtaggt taatgatgtt ttgaagggaa gttgtaaagt aaactagtaa tgcattatag
     5881 gtcattaatt gtccaattga taattcattt ttaataacct ggttagctcc aacccataaa
     5941 atgataaggt taagcgaaag ttgaacaaaa gttttgagtc cttgttgtat attatttaat
     6001 ctagtgtgga ctaatgactt atgtaagaaa tcattaaatt cgttagtaat cttgtcagaa
     6061 cgaacttctt cgcaattaag agatttaata gtttcgattc ctctaatatc ttctataatt
     6121 gatgcactta ctgttgcgtt actttccatt tctttttggt ttagtttcct aaaattacta
     6181 gtaaatgaaa aaattatcag agaataaata ggaataataa gcatagtaat tccgaataat
     6241 ctaatatcct gtaaagcaag aactgtgcct ataattatta aaatagtggc atctaaaaag
     6301 atagatataa ttgcactgac aagagcatca attactttat tcgcgtcagt aaaacgagat
     6361 agaatatcac cagtctttct agtagagaaa aatgccattg gaagtcttaa aacatgcttt
     6421 atatagttta ggataataat tttagatagt ttctgcccta gaattgctaa taagtaatcc
     6481 cgagaaaaag taaatagaga gttaaaaaga taggcgaaca atagtccaat actaataatt
     6541 gctaaaggat cttgaagttt attaggaatt aatatgtcaa gtaaagtttg tagataataa
     6601 gaatttaaaa tattaagaaa cgttacaata aaagctgctg taataattcc aaaaagtagg
     6661 gctttttgtt gaaaaagtgg tcgacataat cttttaaaag tggggatttt ttcctgaata
     6721 ggtttatagt tcttacctgg ttttgcaaaa atagcaattc cggtccattc ttcaaaaaaa
     6781 ttgaccttag gaatacgttt aacttgtata ttaggatcag gatcagcaat aaaaatatgt
     6841 tttttggaac ttttaaaaac aacacaatag tgaagtaggc cactgtcttt ttttatgaga
     6901 tgagcaataa aaggataaat tacatctttt gaatcaaata aactagcatc tgcttgatat
     6961 gcttcaacat ccatttttaa cttttctgct gcttttacaa tcccaagtgc agtagttcca
     7021 tcagtagtgg tttttgtaaa ttttcgcaga gttgctaatg aaattttaga gccgtaatta
     7081 tgaagaatca ttgctagtgc tgctactcca caatcagctt catccacttg atttatatag
     7141 tgtcttctaa agttatacat aaagtgcctc gttaacaagt tagattttta tatagattat
     7201 ttaattcttt agctctgctt ctagaataat ttaaacaatc attgttggaa aacttaataa
     7261 gccgtttttt ggtattaatt gtttcaacat tttgtaagtt aattaagcta gactgcgaag
     7321 ctttgaaaaa tagaggatag ttttgttcaa ttgttttaat atcacctgag aattcccctt
     7381 gaccattaga tgtaacaatc tttaatttat gagggaattt tgtagtagag atataaagga
     7441 tattactgaa gtttacattt ataatccttg taccaacttt ataactgaac gtattttttt
     7501 taatatagtt aaattcattc agttttctta tagctagttc tagggtttcg gttagccgtc
     7561 tttgtaaatc tcgttggttt gtagttttag ttatatagtc caacggatta attcgacgtt
     7621 gaaaggtgag aaaagctagt tcttcatgcg ttgtaataaa gattatttgt gctttttcgt
     7681 taagtgtttt tatcttttga gctaaatcta gaccgccttt tgaactggaa ttttcatcta
     7741 actgaatatc taaaaaggca ataatgttat ttaaatcact attaaattca agataatcta
     7801 atacactttc tgcatcggtt gcaatcaaat caatggtcgg atgaatatct tgttcttcaa
     7861 gaataattga tgacatttta agtagtgtag cgatattttt tgcttgagtc ctgtcatcat
     7921 cgcagacaag taaatggtag tccataagta ttcctttcta ttcaattgaa attgtaaatg
     7981 taaagtaacc attatcagag gagtaagcaa tatatacgtt gtggtatttg ttagctattt
     8041 tttttacagt tgctaatcct agcccttcat gattagcttt atttgtaatt ccttcttggt
     8101 ggagtttatt agtgctaagc tgctttcgac aagtattctt aatttcaaat tctaacttgt
     8161 taggagcact ttgatacagc attgaattga tttctacagt acgtgctcct aactttttta
     8221 aggtttcgca ttcttcaagg gcattatcat aagcgattcc aattattcga attaaatcaa
     8281 ataaatcgat atttgggaga tcattaattt cagttaaaca ttcaaaatga tatttaatat
     8341 ctttttgata aattgaattt aatttactaa taaagatact tcgcaagaca tcatctttaa
     8401 tgtttttagt gtcttggaat tgccaaagag aatctttacc aaggttatct cgagaatagt
     8461 tttctaattt atcgagtaag gcttgattat caccatggat ggcacttagt ttgagactat
     8521 ttagtaagtt ttgataatca tgtttaaatc gtcttaactt cgattgattt tcttctagat
     8581 tttgaataag aaataacaag tctttctttt cctgaagttg aagtttcttt tgctgaattt
     8641 gtctgctaat tcggtatata aagaccgtaa aactacattg aagaactagt aagcaaaaga
     8701 taacaatgaa ggctggtgtt acccgtggag ttgtaaaaat aataaatccc gcgatattta
     8761 aagtaataaa aagataaaat aagatccata aattaatagt tgcatttttg tcttcaattt
     8821 tgtctagggg atggtaatgg tagaaaagaa tgaagataaa taagtaaaag attggatcaa
     8881 taaatagaat ataactagtt ggtagtgaga gtactttatc aatagtaaat gttgagaaat
     8941 cagttaaaat tgatgtggtt aaagttaata ggatagcacc aattaattta ggcttagggg
     9001 ttctattttt aaaatagaaa tataagaagc caccctctaa tatcgttgac agatacgcac
     9061 ctatataacc taagccaatc ataagaaata agatagtgaa aatgatagtc aaacgaaatg
     9121 tatctcgctt agtaactttg atttttatca gatataagaa tattaaaagt tcgaaagtaa
     9181 gagcttggat tactgatata atttgaatca aaatattcat acttaaaatt aattaatgga
     9241 aaatatgtcg taagctgctt atgattttat tggtgtaagt atatgtatta ttatttacag
     9301 atttaaatgt gagtgcataa ccgtaaccac ctttaattaa agatagttgc tgagttgata
     9361 gttttttcat aaataaatct ctcctattgt tttatcagtg atttatttta acaggatata
     9421 tcgataaaat cataaatgat caaaagtggt tgtttagcat tcaaattttg taagaaataa
     9481 atcggattgt ttcaattaat aaagtctttt atttaataag tattaaattt ttatttactt
     9541 tgtttttcta aaagggaaat tgttattata gcatatttaa gtttaactaa attagtgatt
     9601 cagatttaag agttatttca gcatatttag gggaagtgct tgaatttgaa taaaaatcgt
     9661 tgaaattaga agattctata gaactttgtg aaagaattgt atgattaaat tgaaaaaatt
     9721 ataaggagat tattttctat gaagaaatta gaagattttc aattaaaaca aattttaggt
     9781 ggtaagaact catggcaaca gaatgtttat ggttctgttg gtgcggctgc tgcaggtgcg
     9841 ggattaggcg cagctatttg tggcccagcc tgtggattcg ttggtgccca ttatggtgct
     9901 attgcatggg caggagtaac tggcgctaca cacggatttc attaaaaatt tagaaataaa
     9961 agggaaggag aaataataat gcaacaatta aaaaatgaac aattagaatt tattcttggc
    10021 ggaaatcgtt ggggaaatgc aactattggt gcaatgtcag gagcggcgag gggtgtaaaa
    10081 tggtgtcgtc ctgctggagc ttggggtatg gctggttgtg cagtagttgg cgctggagta
    10141 ggtggctatt ttggttatca tagttagtat cttattatag aattaaatga aaaaaattat
    10201 taagaacaat aagtggaata taattgcaat attaatattt tttggccttt gtatatatta
    10261 tgtttatgat aaaaacattg ttatggctag cgattcctta ctgggtgcaa taatctggct
    10321 gattagttgc ttaaataaaa aatatagcta cttagcagga atagcactaa tctcatatgc
    10381 cgtgtttatt ttaattattc gggcagattt atggccggga gcagtcgcat gtatagtaat
    10441 aggattgttt atcttatttt tctatctaaa gaaacttaaa aagcaataat ctagagaata
    10501 aaaggtatga tcccggttaa atattggagt catacctttt tatcctgcac ttcaacttta
    10561 taattttcat tacgcaagac tcttcgttac tttagtttaa atactcaaag tatatgcgat
    10621 agttcttgcg ttttcttgtt tttaaagcac aaacgcatag aatcacagta atttaccacg
    10681 accccatgca tttaaatttc agttacttaa ccaaataccg taaccagacc gctccatcgt
    10741 caaaacttgc aacatctttt aattgcagag cgattggacg actgctttct ggacggccat
    10801 caaaaaggct tggttgaccg gttcgcccat cgacaccagt cccaattaaa atactgattt
    10861 catcaattaa tcccgcttca aggaaaccgc cattgatttt tccaccgcca acaattgcta
    10921 aacggtcaat attaaatttg tcggcaagaa tttccatcgc tttagccagg tcgatttgat
    10981 ctttcccagt tgcgatccat gaaatatttt gccgattgag gtaatcaagg taatctttcg
    11041 taacttgttc actcgtaata atgaggtgag ggaagttatt accattttcc gtgccccatt
    11101 gtaaagttcc tttagtatca acaacgatat tataattatc agcagttgca tttttagcaa
    11161 agtcagtctt accaaggatt tctttgtttt gcggattaaa tttaccatca cgcgtcaatt
    11221 cggtttctgc agtaacacgt ccactaatcc ttgtaggaac atttaaactg tccaatgtag
    11281 aatagtattc gggttcaccg gctaattggg ccgtcattcc acaatcaatt cgtccatcaa
    11341 ctgatgtcat catatggacg ataatatatg gtttattcat ttataaagcc tccttaatat
    11401 ctaattccat catagattaa ggagactatt atttgaaatg cttattatat ttaatacttt
    11461 attcaaagat tgtatatatc attaccacaa actagcaaac caatagacta atggaatagt
    11521 tactaaactc aaaatggttg aaatactcat taagacggtt gctggccgtg catctccatt
    11581 tgattgtaag gtaaaaagaa cgactaatcc tgctactgga catgcactaa gaattactgt
    11641 ggtgaagagt ggaacaccgg tgattcctaa taataataag ataattgtcc ctagaattgg
    11701 gaagaaaata ttccttacga agaggcttcc ccagagcgta gttggtaatt tgatattttt
    11761 aatacttagg ttggcaagat tacttccgat gacaatcatt gatagtggag taaacgctgg
    11821 actggtgtaa tcaataaaac cagaaattaa ttttggcaac cgaaaagaac taatgaatag
    11881 gaaaagacca ataataatag caataatatt aggatttaaa ataattttct ttaactgtgt
    11941 tccccaatca tgaggctgcc gtttttgaaa aattccaatt ccctgggtcc acgacatgac
    12001 attaaaacca atcattgagg cgacagcata gaagacgccc acgcttccaa aaagtccttg
    12061 tgctaatgga acgcccataa agccattatt agaatagata cttccataag ttgcaatttg
    12121 acgaatattt tggtccttta ctttatgaaa aagtagtttt gcaatcaaaa ttgaaacaaa
    12181 ataggtcaga aagacaccag caatcaatag taataattga taaaatcgtg atcgcgaaaa
    12241 cggctgttca aaggccttaa taattacgat tggcgataaa aagtagagtg taatatttgt
    12301 taggtcatta attgattgtg gatggagaaa tccgagcttt ctaataactg cccctaaaag
    12361 cattaataag aaaataatga cgacttggtt aaaaatttgc ccaattgaca ttgcaccact
    12421 tccttcagtt aaaaatcaca attactattt tataacaaaa atctcccctt tttgttgaca
    12481 agcaacataa aacgagtaaa atatatcaaa aagatgttga taagcaacaa agatagaaaa
    12541 gggaatgatt ttatgagtac attattagta atccaagcac atccacatat tgaaaatagt
    12601 ctttctttaa cggtcgggaa gcaattcgtt gatacctata aggaaacgca tcctaacgat
    12661 caagttatta tccgtgacct ttataccaaa gagggcgtcc caccgttaaa tgatgtgacg
    12721 atggaagcat ggcgaaaaca aaaatttgat gaaccaatga cagaagaaga gaaagatctt
    12781 ctaaagcgtc atgaagaatg gttagatgaa tttattagcg ccgataaata tgtatttatc
    12841 aatccaatgt ataaccattt cttaccagca gaaatgaaac aatatttaga ccttacagca
    12901 gttgctcaca aaacatttaa atatacttcc aatgggccag ttggtttatt gacaggcaaa
    12961 aaggcaattc acattcaggc agccggtagc gaatatcata aaagtggaaa gtggggaacc
    13021 gttaaattct taattaaaaa ggcattcgga attaagagca aagaaagttc tgcattaatg
    13081 gatcttggtg atatgtattt gacgaatatg ctaaagttct acggaattac tgatgttgaa
    13141 aaattattta ttgagggtgc cgacgctcat cgcgatcaac ggcaaaagat tcttaatgat
    13201 gcattagcag aagcaaaatc gatggcgaaa gtattttgat ataatggcct taataataga
    13261 tagtgaggcc aagtaatgaa taaagtaaac gaaaaaacaa taaataagat tcgccatacg
    13321 attgaactat tacgcgtaca acacagtaat attcatggct cacaagaaca gcagtggatt
    13381 caagaacact taaccgataa aaaattaaag caagaagtac ttaatttgtc gattgtcgca
    13441 tttcatatcc tatcagtact tgaatcaggt gaacagacag gaatagaaat cgctgaaaag
    13501 ataaatgtta cacgaggggg agttacgcga gccgccaaaa aacttcttca atacgattta
    13561 attttggcga ctaaacattc tgacgataaa aagaaaatat attattcact aacggatgaa
    13621 ggaaagaaac tagcaaaagt ccatgatcag atgcatgaaa caataaagag agaattggtt
    13681 gataaattaa ccgcaaaata ttcaatggat gatttaaaaa ttgttgctaa tttcttgaat
    13741 gatttatatc ggcttgaaca aaaattctaa ttaccagtaa aaaagtttca tatgaaactt
    13801 tttttatttt ccttcaatca aaacagctaa aatagtatat aggacaaaat aattggaggc
    13861 aaaataatga aaaaagctgt aattatgtta gttgaggatg aggaaagtct tgctagtttc
    13921 ttaataaccg aactagaact tgaaggctat gaagtcatct ggaccaaaga tgggcgtgag
    13981 gcactcgata tttttaaaga gaaagatata accttaatct tattagattg gatgctccca
    14041 atttatgatg gtctcacagt tctacgccga attcggcaat caagtaatgt gccgattatt
    14101 atgattacgg ctcgtagtca aacttctgat attagtatgg cacttgatca aggattagat
    14161 gattatatta ctaaaccgtt tgagattgag gaacttttag cacgaattag ggttgtatta
    14221 cgacgattgg gtcaagaaaa agcagagaaa tatgattata aatttggacc atttgaaatt
    14281 aatttactga aacatcaatt tatggttgat ggcaagcagg ttcatttaac gcctaaagaa
    14341 ttttccctca tggttgccct aattaaagaa ccaggagtcg ttcaaacccg tgatgatctt
    14401 cttaatgaaa tatgggggta tgattttgat ggtcagacca atactgttga tgtctatatt
    14461 cgtgctttgc gcaacaagtt aggcaaatac tgcgacttaa ttaaaacggt gcgagggatt
    14521 ggttatgtat taggtgatga gcaatgagta acacacatcc agtaactgca tcgcggcaat
    14581 taactcgtct tttcttaatg ttgtttgcag tgattttagt agttattaat cttctttttg
    14641 tggttaccgc cactaattta atctatcgtt atgctgatga tcaggcagaa gaagtgattg
    14701 agacaattga ggaagattgg cccgaaaatc aaaatcgcga aacttttttg aatgcttatg
    14761 ttgctcgtca agacgatgac gcaatcgaga tcactgatgg taaacgagaa tatacctcac
    14821 ccaaagcccg taaaattttt aaacgaattg accagcgaaa tttagcgatc aagaatctac
    14881 agttaacccg gcatggggtc tattatttac ggcagcaaaa agtccatcat cagcgaattg
    14941 taaaagtagc gattaatgtt gatgatttaa tcaaattaac aggctggctc ttgatagtga
    15001 ctttgttaat taaccttgca ataagcatca ttactctccc aatcattcat cggttggcta
    15061 aacgatggac ccgaccattg actagtttag atagtgaaat cgatgcaatc acaccccaaa
    15121 gtgatcgatt acagacattg acagtccccc aacagccgtt agaagta
//
