LOCUS       c00043_JAJGVW0..       12075 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJGVW010000150.1 Limosilactobacillus reuteri strain Cor124_1_1
            scaffold150, whole genome shotgun sequence.
ACCESSION   JAJGVW010000150
VERSION     JAJGVW010000150
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 16:48:32
            Original ID  :: JAJGVW010000150.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12075
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12075
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[10178:11336](+)"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10179..11336
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     cand_cluster    1..12075
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /kind="single"
                     /product="T3PKS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12075
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T3PKS"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /tool="antismash"
     CDS             complement(92..229)
                     /locus_tag="ctg43_1"
                     /transl_table=11
                     /translation="MGLVTRRSEQLDKLFDQFAVDPKKPKATKKNDDKKEKDNKDKEKK
                     "
     CDS             393..2204
                     /locus_tag="ctg43_2"
                     /transl_table=11
                     /translation="MASEHIEHKLALLPDKPGCYLMKNINDQIIYVGKAKNLKNRVRSY
                     FKSSHTGKVAKMVSEVADFETIVTSTNKESFLLEITLIQKHQPYFNIKLKKGTGYPYIK
                     ITNERDPQIKIVSKIKKDGGYYFGPYPNVYAAEETMHFIQKVYPLRRCNGYQGRPCLYY
                     HMGQCLGACFKEVPKSDYEEQIKKIKSFLSGNTATVKRQLTKKMQLAAENMEFERAAEI
                     RDQLHYIEVTVEKQKIISNDKTPRDLFNFYMDKGWLSIQIFFIRQARLMKREKRLFPIV
                     DTAVEEMTSFILQFYNRRNNILPREILLPKGLPNKEISEILGVPVRTPVRGEKRNLLAM
                     AHENAQLSLDEKFRLLEMDQSKTTGAMKEITDALGLPEGHRIEAFDHSHIQGADPVSAM
                     VVFINGEPAKNFYRKYKLKTVINHADEAASTREVIRRRYSRLLKENKPMPDMIFMDGGE
                     IQMDAAKDILENELGLDIPVVGMVKNDKHQTADLLFGDDDHHINLNPRSQGFYLVQRIQ
                     DEVHRFAITFHRRVHTKHSLSSRLDEIKGVGPRTRTKLLKKYGSITKIAQASVDEIHSL
                     GINRPTAQLIKVSLQKNAEVAKGSSHD"
     CDS             2269..3585
                     /locus_tag="ctg43_3"
                     /transl_table=11
                     /translation="MNMFVDQIKIEVHAGKGGDGMVAFRREKYVPNGGPAGGDGGRGGS
                     IILKVDEGLRTLMDFRYHRIFKAKNGGNGMSKQMTGPSAEDTIIAVPQGTTVRDLDTGE
                     IIGDLVEKDQELVVAKGGRGGRGNIHFASAKNPAPEIAENGEPGEDHYLELELKMLADV
                     GLIGFPSVGKSTLLSVVTGAKPKIAAYEFTTLTPNLGMVMLPDGRDFAMADMPGLIEGA
                     SKGIGLGLKFLRHIERTRVLLHLVDMSSEDPHQAIERYRQINKELANYDPELLKRPQIV
                     VATKMDLPNSADNLATFKADLAADKTLEKQPEIFPISAVTHQGVQQLMQLTADLLDKTP
                     AFDSESHDKELVAEYRAAAPDKKDEADFTITKDEDGIWVLGGEKLIRLFKMTDLTHEES
                     QLRFARQLRHMGVDDALRAKGVQDGDLVRIEKFVFEFIQ"
     CDS             3618..4547
                     /locus_tag="ctg43_4"
                     /transl_table=11
                     /translation="MQLEFLGTGAGSPSKQRNVASVALRLLEERNAIWLFDVGEATQHQ
                     ILNTTIRPRKIEKIFITHLHGDHIFGLPGLLSSRSFQGGTEPLTIYGPVGIKRYVQTSL
                     QVSESRLSYPLHFVEITDDGELFNDHGFRVIARKLDHKIACFGYRIEEADHPGELQVEK
                     LREQKVPSGPIYGQLKAGKKVTLPDGRVLDGHDFIGTPQPGRIVAILGDTRQTKNAILL
                     AQNADVLVHESTFAKDETKMAHNYYHSTSKQAAEIAKKAGVKKLLLNHISARYTGKAAY
                     QLAYQVRNIIPDTRVVNDFDVIDIPFKK"
     CDS             4564..5397
                     /NRPS_PKS="Domain: PKS_KR (14-168). E-value: 6.7e-11.
                     Score: 34.2. Matches aSDomain:
                     nrpspksdomains_ctg43_5_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     190; E-value: 8.4e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_5"
                     /sec_met_domain="adh_short (E-value: 3.1e-33, bitscore:
                     104.8, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRRVKTLRFLRNEVVLITGGSSGIGKELAFEAARRGAIVVVASR
                     NLEKLQEVAKKCLILSGRPAFAYQLDVTDPDQIDDVLSKVQHEVGGIDVLINSAGLGDF
                     IPVVKESYSSMEKMVHTNLLALMYISRCVAKQMMDQGYGAIINMGSLAGKLPTPNSAVY
                     SATKAGVIQFDNVLRMEVADYGVQVLTVNPGPIDTPFFDKADNDYTYRAHLPKWMFISP
                     EDLARQIWNNVGYKTREINVPGYVAYLGWAYQVIPGLGDWAIKKFFDFQQDKKNL"
     CDS_motif       4606..4752
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_5_0001"
                     /evalue="2.10E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg43_5"
                     /protein_end="63"
                     /protein_start="14"
                     /score="17.2"
                     /tool="antismash"
                     /translation="VVLITGGSSGIGKELAFEAARRGAIVVVASRNLEKLQEVAKKCLI
                     LSGR"
     aSDomain        4606..5067
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_5_PKS_KR.1"
                     /evalue="6.70E-11"
                     /label="ctg43_5_PKS_KR.1"
                     /locus_tag="ctg43_5"
                     /protein_end="168"
                     /protein_start="14"
                     /score="34.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVLITGGSSGIGKELAFEAARRGAIVVVASRNLEKLQEVAKKCLI
                     LSGRPAFAYQLDVTDPDQIDDVLSKVQHEVGGIDVLINSAGLGDFIPVVKESYSSMEKM
                     VHTNLLALMYISRCVAKQMMDQGYGAIINMGSLAGKLPTPNSAVYSATKA"
     aSModule        4606..5067
                     /domains="nrpspksdomains_ctg43_5_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg43_5"
                     /tool="antismash"
                     /type="pks"
     CDS             5531..7858
                     /locus_tag="ctg43_6"
                     /transl_table=11
                     /translation="MIDAKFKWKLADNASSATVDNLEKELGISRILATLLAQQGIDSTE
                     QAKKFFEPSMEEIHDPTLLHDMDKAVERIEQAVEKQEQITIYGDYDADGITSTSLMYET
                     LLSVGANVNYYVPNRFTDGYGPNMDAYQRLIDNGTQLFITVDNGVSGKNVIDKVMAAGV
                     DVVITDHHELPADLPNAVAIVHPRYPGSNYPFPDLSGVGVAFKVAWALTGEFPIEELDL
                     VAIGEIADVVNVTDENHALISYGIQQLRQGMRPGLAALMELADIKANNLTDQDIGFGIA
                     PRLNALGRIADANDGVKLLTSLDENESQKLAKEVDQANKERQNLVAEIMKEAEKQANSS
                     ANQQKKTLLIVGKGWHQGVLGIVASRIMNETGKPTIVASTDQNNPTLIKGSGRSVDSFN
                     LFNALEAHRELFTTFGGHPAACGLSFDQGNIAPLQIALEEEANQQKFDPTVKQTLPIAM
                     QLEPADVTQQLYNDIQRVAPFGPGNMEPVFELNNVKVVDVKTMGQEHQHLKFSIVSGKE
                     NLTVVAFGQGNLATLLSAPTGQVNLAVKVSLNEWRGKKSVQLMLEDLQINGTVIIDERT
                     NKLTPQLFSSSDYYIVREPRLRDNIAPHVAPGYTLSIEEAIKTDFSGQRVTLVDCPSSE
                     EMLKQIFTEDEGEPATIRLLLYQRKSAYLAGLPTRNDFAQLYRFIYKQKELKWPMQVKA
                     VSNHLKINMDRLNLMIQVFSEAGFVTIKDDVLKFNEPTNKTDLTQTKRYQKQLAQYKVE
                     QQLLFNDAATVAKWLLEYLNLE"
     CDS             7875..8393
                     /locus_tag="ctg43_7"
                     /transl_table=11
                     /translation="MALDLYKYVASVPDYPEKGVIFRDILPLMADGAAFKQATDELVDY
                     AKDKKVDMVVGPEARGFIVGCPIARELGVGFAPARKKGKLPRKAISASYDLEYGTATLQ
                     MEADAIKPGQRVLVVDDLLATGGTISATIDMVEQMGGIVVGCAFLIELKDLHGRDKLKD
                     YDMKALMEF"
     CDS             8504..9118
                     /locus_tag="ctg43_8"
                     /transl_table=11
                     /translation="MIFLVIMGALFLILGGFYLANSWQQYREWKSGTIIVVLSIIAIVY
                     GVINLPYFHHNNSASSSQSASSSQVARSSSFSSFSNGLTIGNSSANEAQQESKTMAVLR
                     QMQKGYSKLGSVDYNEDSKTFQITPTDDNTVEALKALAQDPSQAEQMGWPNLTKSIKSN
                     SGQVEKALGDGYSISIMNPSDSSKALYTAKDGKTTYDIANQ"
     CDS             9485..10153
                     /locus_tag="ctg43_9"
                     /transl_table=11
                     /translation="MVKKYYAVKKGRHPGIYKTWAECQKEVNGYPNAKFKSFLTLKGAN
                     EWLQATGNTVPSTKAVNYSDDILVYTDGGSRNHGNKLGQHVKADDKAAWAYFIQTKDQA
                     YTGTAGEFGATNNKMEITALIKALTKLLELGFQAQPITAILDSHYVLDPIMKGWLTNWQ
                     RRGWLTAGGKPVANKELWEEIVALLPQFPNLHFDWTKGHATNAGNNKVDELLNKTMDQL
                     "
     CDS             10179..11336
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:hydroxymethylglutaryl-CoA synthase (Score: 533;
                     E-value: 6.7e-162)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_10"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 3.8e-09,
                     bitscore: 25.8, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGIDKMAFATTNDYLDLVELAKERGVDPNKFTIGIGQDLQAVV
                     PPTQDIVTLGATAAKKLLTPELEKNISTVIVATESGIDNSKASAIYIKHLLGLSDFIRT
                     VEMKEACYSATAAIQFAKGVVALNPQETVLVIAADIARYGLNTPGEVTQGAGAVAMLIS
                     RNPHILTLEDTTVAYSKDIMDFWRPLYATEALVDGKYSTNVYIEFFLQTFTRYQQLTGR
                     ELADFAALTFHMPFTKMGKKGLEGLLKDRNDEVAQRLRTQLTASQLFSRQVGNLYTGSL
                     YLSLMSLLQNSDLRAESRIGLFSYGSGAEGEFYTGILEDGYEHYMNNIQEELKHRHQVS
                     VAEYEKLFSSQLGMNDRDIEFDVTTDPLPFVLKGQKDHQRIYEAK"
     CDS             complement(11487..11945)
                     /locus_tag="ctg43_11"
                     /transl_table=11
                     /translation="MANKLNSLAHTKWLCKYHIVFIPKYRRKAIFNQYRRDLRDYIRLL
                     CKYKGVEIIEGHMMPDHVHLLVSIPPKLSVSQFMGYLKGKSALMMFDRHANLKYKYGNR
                     HFWAEGYYVSTVGLNESTIKKYIRDQEKHDIAMDKLTSVEYSDPFKGK"
ORIGIN
        1 gtgattaagt tgtcgaaccg ccgtatacgg aaccgtacgt acggtggtgt gagaggtcga
       61 taattgaact aatcaattat ctcctactcg attatttctt ttctttatcc ttgttatctt
      121 tttctttttt gtcgtcgttt tttttagttg cttttggctt tttagggtca accgcaaatt
      181 gatcaaataa tttatcaagc tgttcgcttc ttctagtaac taatcccatt tttttagctc
      241 cttttttata tttgacaaaa tgctagcata aattttacta aatgtacaat tatttctaaa
      301 cactttcttt tatttctaaa cactttcttt gccttaatga tgatttttca gatataatat
      361 attgttagat aatttttcgg agggattttg cgatggccag tgaacatata gaacataaac
      421 tagcattgtt acctgacaag ccaggttgct acctgatgaa aaacattaat gatcagataa
      481 tttatgttgg taaagctaaa aatttaaaga atcgagtgcg ctcttacttt aagagtagtc
      541 ataccggtaa agtagctaaa atggtttcgg aagttgcaga ctttgaaacc attgtgactt
      601 cgactaataa ggagtcgttc ttacttgaaa taacgctgat tcaaaaacat caaccttatt
      661 tcaacattaa attaaaaaag ggaactggtt atccctacat aaaaataaca aatgagcggg
      721 atcctcaaat taagatcgtt agtaaaataa aaaaagatgg gggatattat tttggcccct
      781 atcctaatgt ctatgctgcc gaagagacaa tgcatttcat tcaaaaggtc tacccattgc
      841 gccgttgtaa tgggtatcaa ggccgtccat gtttgtatta ccatatggga caatgtttag
      901 gagcttgttt taaagaagtt cctaagagtg attacgaaga gcaaattaag aaaattaagt
      961 catttttgag tggaaacaca gcgacagtta agcgacagtt aaccaaaaag atgcaactag
     1021 cagcagaaaa tatggagttt gaacgagctg ctgaaattcg agaccagctt cactatattg
     1081 aagtgacggt tgaaaaacaa aagattattt caaatgataa gacccctcgt gatttattta
     1141 atttctatat ggataaaggg tggctttcta ttcaaatttt ctttatccgg caagcgcggt
     1201 taatgaaacg agaaaaacgc ctatttccaa tcgtggatac ggcagtcgaa gaaatgacca
     1261 gctttattct ccagttttat aatcgtcgta ataatatttt gcctcgtgaa attctccttc
     1321 ccaagggcct ccctaataag gaaataagtg aaatactagg agtaccggtt cggacccctg
     1381 ttcgtggtga aaaacggaat cttttagcaa tggcacatga aaatgctcag ttgtctttag
     1441 atgaaaaatt tcggctgctt gagatggacc aaagtaaaac tactggtgcg atgaaagaga
     1501 ttacggatgc tcttggactt cctgaaggtc accggattga agcatttgat cattctcata
     1561 ttcaaggagc tgatcctgtt agtgcaatgg ttgtatttat taatggagag ccagctaaaa
     1621 acttttaccg gaagtataaa ttgaaaacgg tgattaatca tgctgacgaa gctgccagta
     1681 cccgggaagt tattcggcgg aggtattcgc gtctcttaaa agaaaacaag ccaatgcctg
     1741 atatgatttt tatggatggt ggggaaattc agatggacgc ggctaaagat attttagaga
     1801 atgaacttgg tctcgatatt ccggtagtag ggatggtaaa gaatgataaa caccaaaccg
     1861 ctgacttatt gttcggggat gatgatcacc atattaattt gaatccacgt agccaaggct
     1921 tttacttagt tcaacgcatt caagatgagg ttcaccggtt tgcgattact ttccaccggc
     1981 gcgttcatac caagcattcg ttgagctcgc gtttggatga aattaaggga gtgggacccc
     2041 gaactcgaac aaaattgctt aaaaaatatg gatcaattac caaaatcgct caggcatcgg
     2101 ttgatgaaat tcattcacta ggaattaatc gacctaccgc ccagctaatc aaggtttcat
     2161 tgcagaaaaa tgctgaggtg gcgaagggta gtagtcatga ttgagttttg acaggcttgt
     2221 aaattttaaa tatactaaat aatagactaa agaacggaga caatcattat gaatatgttt
     2281 gttgatcaaa taaaaattga agtacatgca ggtaagggtg gcgatggaat ggtagcattt
     2341 cgtcgtgaaa aatatgttcc taacggtggc ccagccggtg gggatggtgg ccgtggtggc
     2401 agcatcattt taaaagttga tgaaggatta cggactttaa tggatttccg ttatcaccga
     2461 atttttaaag ctaaaaatgg tggcaatggg atgagtaaac agatgactgg tccaagtgca
     2521 gaagatacaa ttattgctgt tcctcaaggt actactgtta gggatcttga tacaggggag
     2581 attattggtg atcttgttga aaaagatcaa gaattagtag ttgctaaagg tggtcgtggt
     2641 ggccgcggca acattcactt tgccagtgct aaaaatcctg ctcctgaaat tgcggaaaat
     2701 ggtgaaccag gagaagacca ttacttagaa ttagaattaa agatgcttgc tgatgtcgga
     2761 ttaattggtt ttccttctgt tggaaagtca actttattat cagtagtaac tggcgctaaa
     2821 cctaaaattg ctgcatatga atttacgact ttaactccta atctggggat ggtaatgtta
     2881 ccagatggtc gtgattttgc aatggctgat atgcctggtt taattgaagg agcatcgaag
     2941 ggtattggcc ttggattgaa gttcttacgg cacattgaac gtacgcgcgt tcttcttcac
     3001 ctagtggata tgagtagtga agatcctcat caagcgattg aacgttaccg gcaaattaat
     3061 aaggaacttg ctaattacga tcctgagtta ttaaagcgac cacaaattgt agttgcgaca
     3121 aagatggatt tgccaaattc tgccgataac ttagctactt ttaaagctga tttggcagca
     3181 gataagactt tagaaaagca gccagagatt ttccctattt cagcggttac tcatcaaggt
     3241 gttcaacaat taatgcaatt aactgctgat ctcttagata agacgcccgc atttgatagt
     3301 gagagtcatg ataaagaatt ggtcgctgaa tatcgtgctg ctgctcctga caagaaagat
     3361 gaagcggact ttaccattac caaggatgaa gacggcatct gggtattggg cggtgaaaaa
     3421 cttattcggt tatttaagat gactgattta actcatgaag aaagtcaatt acgctttgct
     3481 cgtcaactcc gccatatggg ggttgatgac gcgttaagag ctaaaggtgt acaagatggc
     3541 gatcttgtaa gaattgaaaa atttgttttt gaatttattc aataaaatta tacgtagcaa
     3601 aggtaggaaa aatataaatg caacttgaat ttttaggaac aggcgctggt tccccaagta
     3661 agcaacgtaa tgtagcaagt gttgcattgc ggttgttaga agaacgaaac gcaatttggc
     3721 tatttgatgt gggagaagct actcaacatc aaattctcaa tacgacaatt aggccacgaa
     3781 agatagaaaa aatctttatt actcacttgc atggtgatca tatctttggt ttacctggtt
     3841 tactaagttc ccgctctttt caaggaggaa ccgaaccatt gacgatctat ggaccagtag
     3901 gaataaagcg gtatgttcag acttctttgc aagtaagtga gtcacgcctc agttatcctt
     3961 tgcactttgt tgaaataaca gatgacgggg aactatttaa tgatcatggt tttagagtga
     4021 ttgcacgaaa gttggatcat aaaatcgctt gttttggata ccggattgaa gaagcggatc
     4081 atccaggaga attacaagtt gagaaattac gagaacaaaa agtaccatcg ggaccaattt
     4141 acggccaatt aaaagctgga aaaaaggtta cccttcccga tggtcgcgta ttagatggtc
     4201 atgactttat tggtaccccc caacctggac gtattgttgc aattctaggt gatactagac
     4261 aaacgaagaa tgcaattctg ttggcgcaaa atgcagatgt attagtgcat gaaagtactt
     4321 ttgctaaaga tgagacaaag atggcacaca attattacca ttcaaccagt aaacaagcag
     4381 ctgaaattgc gaaaaaagct ggtgttaaaa aattgttgtt aaatcatatt tcagcacgat
     4441 acactggtaa agcagcttat caattggcat atcaagttcg taatattatt cctgatactc
     4501 gagttgttaa tgattttgat gtaattgata ttccgttcaa aaaatgaaaa gagatggcaa
     4561 aagatgctga gaagagtaaa gacgttacgt tttctgcgaa atgaagttgt actaattact
     4621 ggtggttcaa gtggaatcgg caaagagttg gcttttgagg cagctcgtcg cggcgcaatt
     4681 gttgttgttg cttctcgtaa tcttgagaag ttgcaagagg tagctaaaaa atgtctgatt
     4741 ttatcaggtc ggccagcatt tgcttatcaa ttagatgtca ccgaccctga tcagattgat
     4801 gatgtgcttt cgaaggttca acatgaagta ggaggaatcg atgtattaat taattctgct
     4861 gggcttggtg actttattcc cgtagttaag gaatcttaca gctcaatgga aaaaatggta
     4921 catacgaacc tcttagcctt aatgtatatt agtcgatgtg tggctaaaca aatgatggat
     4981 caagggtatg gggccattat taatatgggt tcattagctg gtaaattacc tacaccaaat
     5041 agcgctgtat attcagcaac gaaggccggg gtaatccaat ttgataacgt tttacgaatg
     5101 gaagttgctg attatggtgt ccaagtgttg acagttaatc ctggtccaat tgatacgcct
     5161 ttctttgata aagcggataa tgattatacg tatcgggccc atttaccaaa atggatgttt
     5221 atctctcctg aagacttagc tcgacaaatt tggaataatg ttgggtataa gacgagggaa
     5281 attaatgttc caggatatgt ggcttatctt gggtgggctt accaagttat tcccggttta
     5341 ggtgactggg caattaagaa attttttgat ttccaacagg ataagaagaa cttataatat
     5401 gctcccttat tttcgtgaaa ttgcagaatt tagcagtttc tttcaaaaaa tgaaagggac
     5461 aaaacaaaag agactgagtt tatcccagcc tcttgtttaa ttttggcgtt gaaatggtgg
     5521 ttaattttaa atgattgatg caaaatttaa gtggaaactt gccgataatg cttcctcagc
     5581 aactgttgat aatctcgaaa aagagttagg catttctaga atattagcaa ccttattagc
     5641 tcagcaagga atcgattcaa ccgaacaagc aaaaaaattc tttgaaccat cgatggaaga
     5701 gatccatgat ccaaccttat tgcatgatat ggataaagca gttgagcgaa ttgagcaggc
     5761 agttgaaaag caagaacaaa ttactattta tggtgattat gatgcagatg gaattactag
     5821 cacatcctta atgtatgaaa cgttattatc tgtcggtgct aatgttaatt actatgtgcc
     5881 aaatcgtttt acagatggat atgggcctaa catggatgct taccaacggc ttattgataa
     5941 tggtacccag ctttttatta cggtggataa tggcgttagc ggaaaaaatg ttatcgataa
     6001 ggtaatggca gcaggagtag atgttgtaat tactgatcac catgagttgc cagctgatct
     6061 gcctaatgca gttgcgattg ttcaccctcg ttatcctggt agtaattatc cttttcctga
     6121 tttgtcaggc gttggggttg catttaaggt ggcctgggct ttaaccggtg aattccctat
     6181 tgaagaactg gatttagttg caattggtga aatagctgat gtagtaaacg ttacggacga
     6241 aaatcatgcg ttaatttcct atggcattca gcaattacga caggggatgc gtccaggatt
     6301 agcggcttta atggaattag ctgatattaa ggctaacaat ctaactgatc aggatattgg
     6361 ctttggaatt gcaccacggc taaatgcact tggccgaatt gctgatgcta atgatggagt
     6421 taagctgctg acgagtttgg atgagaatga atcacaaaaa ttagctaaag aagtagatca
     6481 ggcgaataaa gaacgtcaga atctagttgc tgagattatg aaagaggcag aaaaacaggc
     6541 taatagctca gctaaccagc agaaaaagac cttattaatt gttggaaaag gttggcatca
     6601 aggcgtatta ggaattgttg ccagtcggat tatgaatgag accggaaagc caacaattgt
     6661 cgcatcaact gatcaaaata atccgacctt aataaaaggg tctggtagaa gcgttgacag
     6721 ttttaatttg ttcaatgcct tggaggctca tcgtgaacta tttacaacat ttggtgggca
     6781 ccctgctgct tgtggtctat cttttgacca gggaaatatt gcgcccttgc aaatagcctt
     6841 ggaagaagaa gcaaatcaac aaaaatttga tccaacggta aagcaaactc ttccgatcgc
     6901 aatgcaactt gaaccagctg atgttaccca gcagttatat aacgatattc aacgagttgc
     6961 tccatttggc ccaggaaata tggaaccagt ttttgaatta aataatgtta aagttgtcga
     7021 tgtcaaaaca atggggcaag aacaccagca cttaaaattt tcgattgtaa gtggtaaaga
     7081 aaatctaacg gtcgttgctt ttggtcaagg aaacttggca acactattat ccgcgccgac
     7141 cggacaagtt aatttagctg ttaaagttag cctcaatgag tggcgtggta aaaaaagcgt
     7201 ccaactgatg ctagaagacc tgcaaatcaa tggaacagta attattgatg agcgaacgaa
     7261 taagttaact cctcagcttt ttagttcttc agattattac attgtaagag aaccaagatt
     7321 acgagacaac attgctcctc atgtggcccc cggctatact ttatcgatcg aagaagcaat
     7381 taagactgat ttttctggtc aacgagttac gttagttgac tgtccatcta gtgaagagat
     7441 gctaaaacag atttttacag aggatgaagg agaaccggca actattcgct tattgctata
     7501 tcagcgaaaa agtgcctatt tagctggact tccaacacga aatgattttg cacagcttta
     7561 tcgatttatt tataagcaaa aagaattaaa atggccaatg caagttaaag cagttagcaa
     7621 tcatttaaag attaatatgg atcgattaaa tctaatgatt caagtgtttt ctgaagcagg
     7681 atttgttaca ataaaagatg acgtgttaaa gtttaatgag ccaactaata agactgattt
     7741 aacgcaaact aaacgttatc aaaaacaatt agcacaatac aaagttgaac aacagttgct
     7801 ttttaatgat gcggcaacgg ttgctaaatg gctattggaa tatctaaatt tagagtaagg
     7861 agactattta tctcatggct ttagaccttt ataaatacgt agctagtgtt cctgattatc
     7921 cagaaaaggg tgttattttt cgggatattt tacccttaat ggctgacgga gctgcattta
     7981 agcaagctac tgacgaatta gttgattatg ctaaggataa aaaggtagat atggtagtag
     8041 gaccagaagc gcgaggcttt attgttggat gtcctattgc tcgtgaattg ggtgttggat
     8101 ttgctccagc acggaaaaaa ggtaagttgc caagaaaagc aattagtgca tcttatgact
     8161 tagaatatgg aacagctacc ttgcaaatgg aagccgatgc aattaaacca ggacaacgag
     8221 ttcttgttgt ggatgatctt ttagctacag gtggaacaat ctccgcaacg attgatatgg
     8281 ttgaacaaat gggtggtatt gttgttggct gtgcgttctt aatcgaatta aaagatcttc
     8341 atggtcgtga taaacttaaa gattacgata tgaaggcatt aatggaattt taattaggag
     8401 gaggctgggg atactagcct tttttctttt taaattatag ttgtatatat acaatgaatg
     8461 cgggacaata acattacgtt gataaaaagg agccagttaa tttatgattt tcttagtaat
     8521 aatgggagcc ctatttttaa ttttgggtgg tttttatctt gctaattcat ggcaacagta
     8581 ccgtgaatgg aaaagtggga caatcattgt tgtattgagt attatcgcaa ttgtttatgg
     8641 tgtgattaat ttaccttatt ttcatcataa taattctgct agctcaagcc aaagtgcttc
     8701 atcttcacag gttgcgcggt ccagtagctt ttcatcattt tcaaatggat tgacaattgg
     8761 caattcaagt gcaaatgaag cacaacaaga aagtaagaca atggctgttt tgcgtcaaat
     8821 gcaaaagggt tattcaaaat taggttcagt tgactataac gaagatagta agacattcca
     8881 gatcacgcca actgatgata atacggttga agcgttgaaa gctttagcgc aagatccaag
     8941 tcaggctgaa caaatgggct ggcctaactt aactaagtcg attaaaagca attcagggca
     9001 agtagaaaaa gcattaggtg atggatattc aattagtatt atgaatccaa gtgattctag
     9061 taaggcgttg tatacggcca aagatggcaa aactacatac gatattgcta atcaataaaa
     9121 ctaaataact taagattagt tcaagaaaga ttggggcact taataggtgt ccttttttgt
     9181 gtaataaaaa agctgatata ccaacgtttt aataacgatt gaatatcagc aaaactttag
     9241 ataaaggaga caaggggatt tgaacccctg cacgctttta cacgcctaac ggttttcgaa
     9301 accgtcctct tcagccactt gagtatgtct ccatttcaac tctattattg taacaaaaaa
     9361 gttgtaaagc gtaaagagaa tatcaattaa ggaaatagct atttaataat tttgcagaaa
     9421 tgatttcttg ctgatatgat attctaatat atgatgtaat ttgaaattta attaggggat
     9481 ttttatggta aaaaaatatt atgcagtcaa aaaaggtcgt catccaggaa tatataaaac
     9541 ttgggctgaa tgtcagaaag aagttaatgg atatccaaat gctaagttta aaagcttttt
     9601 aacgcttaaa ggtgctaatg agtggcttca ggctacggga aataccgtgc cctcgactaa
     9661 agcagttaat tattctgatg atatccttgt ttatactgat ggaggctccc gcaatcatgg
     9721 taataagtta ggacagcacg ttaaggcaga tgataaagcg gcctgggctt attttattca
     9781 aactaaggat caagcttata caggaactgc tggcgaattt ggagctacta ataataaaat
     9841 ggagattaca gctttaatta aagcactaac taaactatta gaactcggct ttcaagctca
     9901 accaattaca gcgattttgg attcacatta cgtactagac ccaattatga aaggctggtt
     9961 aactaattgg cagcggcggg gatggttaac cgctggtggc aagccagtag caaataaaga
    10021 actatgggaa gaaattgttg cccttttacc tcagttccct aatttacatt ttgattggac
    10081 taagggtcat gcaacgaatg ctggaaataa taaggtcgat gaattactaa ataaaacgat
    10141 ggatcagtta taattattta acaagaggat gataagaaat gagaattggt attgataaaa
    10201 tggcttttgc aacaacaaat gattatttag atcttgttga attagcaaaa gaacgcggcg
    10261 tagatcccaa taaatttacc attggaattg gacaggatct acaggcagtt gtgccaccta
    10321 cgcaagatat tgtaacttta ggagctacgg cagcgaaaaa attgcttact ccggaattag
    10381 aaaaaaatat ttcgacagta attgtggcaa ctgagtcagg gattgacaat tcaaaagcaa
    10441 gcgcgatcta cattaaacac ttattagggc ttagcgactt tatccgaacg gtagaaatga
    10501 aagaggcttg ttattctgca acagctgcta tccaatttgc aaagggagta gtggcactta
    10561 atccccaaga aactgtatta gtgatcgctg ctgatattgc tcgttatgga ttaaatactc
    10621 caggagaggt gactcaagga gctggagcag ttgcaatgct gatttcgcgg aatcctcaca
    10681 ttctaaccct tgaagataca actgttgctt acagtaagga tataatggat ttttggcgac
    10741 cgctatatgc aacagaagca ctagtagatg gaaaatactc tactaatgtt tatattgaat
    10801 ttttcctgca aacttttacc cgttaccagc aattaactgg gcgagaatta gcggattttg
    10861 ctgctcttac atttcatatg ccatttacta aaatggggaa gaaaggatta gaagggttgc
    10921 tcaaagatcg taatgatgag gtagctcaac gattacgaac acaattaacc gcaagtcagc
    10981 tattttcgcg ccaagttggt aacctgtaca ctggctccct atatttatca ttaatgtcat
    11041 tgttgcaaaa tagtgacttg agagctgaaa gccgaattgg gttatttagc tatggctctg
    11101 gtgcagaagg ggagttctac acaggaatcc tagaagatgg ctacgagcat tatatgaata
    11161 atattcaaga agaattaaaa catcgtcacc aggtttcagt ggcagaatac gaaaaactat
    11221 ttagtagtca attaggaatg aatgatcggg atatcgagtt tgatgttact actgatccat
    11281 tgcctttcgt tcttaaagga caaaaggatc atcaacggat ttatgaagct aaataaccta
    11341 atcataacca cccgtcaaac gggtggtttg cacatcggct ataagccgat aataaaagcc
    11401 ggcgtctcaa ggcgctggct ttcgctttgc tcaagccaaa atgctctgac tactttgcca
    11461 ccgctttaag cggtgtttgt actacctcac ttacccttaa aagggtccga atattccaca
    11521 cttgttagct tatccattgc tatatcatgt ttctcttgat ctcggatata cttctttatc
    11581 gtggattcat tcaatccaac tgtactcaca tagtagcctt cagcccaaaa atgtcggttc
    11641 ccatatttgt attttaagtt tgcatgtcga tcaaacatca ttaatgcact tttccctttt
    11701 aagtatccca taaactgtga tacgcttagt ttcggcggaa tacttactaa caagtgcaca
    11761 tgatctggca tcatatgacc ttcaattatt tctactccct tatatttgca caacaaacga
    11821 atataatctc ttaggtctct tcggtattga ttgaaaatcg ctttacgtct atactttggt
    11881 atgaatacga tgtgatactt acataaccac ttcgtatggg ctaagctatt taatttatta
    11941 gccatattta tataacctct tttcccttat tgactttggc ttgaacacct acatcttaag
    12001 gcaaaagagg ccttttttat ataattttta tcgcccaccc gcatagcagg tggttttttg
    12061 tttcgtgcat tcgct
//
