LOCUS       c00017_JAGSSZ0..       14186 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAGSSZ010000024.1 Streptococcus thermophilus strain B9 Contig_24,
            whole genome shotgun sequence.
ACCESSION   JAGSSZ010000024
VERSION     JAGSSZ010000024
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:52:20
            Original ID  :: JAGSSZ010000024.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14186
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14186
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[236:9186]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      237..9186
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14186
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14186
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(237..491)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_1"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4.5e-14,
                     bitscore: 46.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENLNTLDLETLASVEGGGCSWGGAGGATVQGAIGGAIGG
                     AFGGNVVLPVVGSVPGYLAGGVLGGAGGTVAYGATCWWS"
     CDS             complement(742..1143)
                     /locus_tag="ctg17_2"
                     /transl_table=11
                     /translation="MKLKNISSSVLRSFRTITAALAVFLISISLSLYKSKISPGTWLTV
                     GALAFVVIFVNGLLYRMLKKRPDSVNLLTIRQSFIVFPVITFLVLSVEFYTLLTFSDTT
                     DRIVLAVLMLLLILCDFLSYLQVKKYFKQ"
     CDS             complement(1473..1640)
                     /locus_tag="ctg17_3"
                     /transl_table=11
                     /translation="MFKNSKPYLLATILIVMGLANLFRSLDAVHHTINLLGLTVLLYSL
                     LFKKWVQFQK"
     CDS             complement(2148..2378)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_4"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.1e-18,
                     bitscore: 60.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGVCSWGGFAKQGVATGVGNGLRL
                     GIKTRTWQGAVAGAAGGAIVGGVGYGATCWW"
     CDS             complement(2734..2934)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_5"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.2e-08,
                     bitscore: 28.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNKQLERFKKLDTNALSNVSGQGYGAQCVIGTTGMTIVGAAFFG
                     IAGAGAGFAGGSTAFCYDTAK"
     CDS             complement(2953..3129)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_6"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.2e-11,
                     bitscore: 37.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTIENFNTLDLETLASVEGGLSCDEGMLAVGGLGAVGGPWGA
                     VGGVLVGAALYCF"
     CDS             3385..4116
                     /locus_tag="ctg17_7"
                     /transl_table=11
                     /translation="LKIYLLEDNSIQMGRLEEAVAHELKSFGKDLSCVQSFDKPDQLLS
                     AITSNTSDQIFFLDIEIKGEDKKGLDIAKIIRQNNPYAIIAFVTTHIEFMPQAFGVTAY
                     KYINKTLDEASFRKEIGETIAQVFPINATTTDEFFLYKTESQLINLPMDQILYLSTSDI
                     KHHVHLQTIHTLMDIRANLADFKKIHKKLYPCHRSYIVNTDMIISVNKTNYEATLINGQ
                     VLPVSRMKIGKIAQIVEERGR"
     CDS             4113..5456
                     /locus_tag="ctg17_8"
                     /transl_table=11
                     /translation="MMLTTLWLLFLTLLSAGLEIILFLYLMGQKIRLRYFFLLLIFNLA
                     FNFIYNHSSWFIIKFWGEDIYYLLLSFLLSTKTKKPLKIKIFNGLFPDILNNLSLRLIT
                     FFIFPFFNISITDYKSSLLISIPSSIAPLCLSFLFIKLFKESFTILQKQKSNSPIQHII
                     IVANFFMFGYTLLLQSLMYLENTTHSSTLELRKLCIVISLVLFFIMIVFLERNIREMIQ
                     GQLDFQKNLQLENLYTYNKHIECLYNSVRSFRHDYSNLLVTLRLGIDKDDMDIVKEVYD
                     SVLQESDKRLNTRNFDLARLVNIQDNTLKSLLSAKVLQAEEEGIEAQISIPEPIHLIGM
                     ETLDFIIVTSIFLDNAIEGAIQTQNPKITISFWEDHCSQLLSISNTISEEKTETKTIFE
                     RGVSNKGRERGIGLANVTEILDNYINVNLETQSNNFSFTQQLTITKKA"
     CDS             complement(5474..5635)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_9"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.6e-08,
                     bitscore: 27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANNTINNFETLDNHALEQVVGGSGWMDYINGFLKGFGGQRTLPT
                     KDYNIPQA"
     CDS             complement(5650..7017)
                     /locus_tag="ctg17_10"
                     /transl_table=11
                     /translation="MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEV
                     TVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKVVKKGDTLVQYSETMEASQKEGLQK
                     QLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKTNTE
                     VNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQ
                     YATTPDASVTDQYLSQVNTNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQF
                     LQNAGQQLSSVETQINDTESKINQADVLLTNTLIQSPEDGILHLSQADKKATMAATGTE
                     LAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSA
                     TETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ"
     CDS             complement(7033..9186)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 306.8; E-value: 5e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_11"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1103.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.3e-44, bitscore:
                     145.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRFRRTFVPQIDMRDCGVAALASVAKYYGSDYSLAHLRELAKTN
                     KEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDVPYPFIAHVNKDGKLQHYYVIYKST
                     KDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPLIFK
                     QRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMM
                     TFARDYLLTILSQRFTIDVILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALAS
                     TILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTLIVFAFMKPFERMNHDVMQSN
                     AMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFIDYLDNSFRLSKLSILQTSLKQGAQ
                     LILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRL
                     NEVYLIESEFGQSDDTYQEGIADGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVG
                     VSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHINYLPQQSYIFSGSVLE
                     NLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARAL
                     LTKSPVLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDHGR
                     VVETGSHQDLMSYPGFYYQLFRK"
     CDS             complement(10200..11945)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     284.6; E-value: 9.7e-87)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 309.1; E-value: 1e-93)"
                     /gene_kind="transport"
                     /locus_tag="ctg17_12"
                     /transl_table=11
                     /translation="MPNQNQWSVFKRLLTYLKPYKFLTFLALTFLLSTTVIKSIIPLVA
                     SYFIDHYLHDMNQAASMILIGYYGLYLLQTLVQYLGNLFFARVSYSIVRDIRRDAFANM
                     EKLGMSYFDKTPAGSIVSRLTNDTETISEMFSGTLSSFISAIFIFVTTLYTMMILDIRL
                     TGLIVLFLPLIVLLVNLYRKKSVAIIEKTRALLSDINAKLSESIEGIHIIQAFNQEKRL
                     KKEFDAINEEHLIYASRSISLDSLFLRPAMSLLKLLAYAVLMAYFGYRGIYLGITAGTM
                     YAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPEQRDTAAKVTEGNI
                     RFENVSFSYDGKHQILDNISFSVNKGETIAFVGSTGSGKSSIINVLMRFYEFQSGRVLI
                     DGVDIRDYSQAELCKNIGLVLQDPFLYHGTIKSNIAMYQDLTDEEIKAAAEFVDANHFI
                     DKLPEGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETEAIVQNS
                     LAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIEHGSHEELLALGGTYHKMYSLQAG
                     AMEGE"
     CDS             complement(11938..13695)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 389; E-value:
                     6.4e-118)"
                     /gene_kind="transport"
                     /locus_tag="ctg17_13"
                     /transl_table=11
                     /translation="LFFKESIIAKLWWFFKLEKRRYIVGILALSLVSVLNLIPPMVMGR
                     VIDAITSGKLTNQILLLNLVYLLLAALGMYYLRYVWRMYILATSYRLGQIMRSRLFEHF
                     TKMSPSFYQKYRTGDLMAHATNDINSLTRLAGGGVMSAVDASITALVTLITMFFSISWQ
                     MTLMAVLPLPFMAFATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQEA
                     ELQSFQETNKMTFEKNMHTMKYDSLFDPLVLLFVGSSYVLTLLVGAFMIQAGQITVGNL
                     VTFITYLDMLVWPLMAIGFLFNITQRGNVSYQRIETLLEQESDVQDPAYPLPSIENGRL
                     DFAIDRFAFEDEDTLRDIHFTLDKGQTLGLVGPTGSGKTALVKLLLREHDVNQGAIYLN
                     GHDIRDYRLSDLRSLIGYVPQDQFLFASSILDNIRFGNPDFSIDKVEEATKLAQVYDDI
                     KDMPEGFETIIGEKGVSLSGGQKQRLAMSRAMILNPEILILDDSLSAVDAKTEHAIIDN
                     LKHTRKDKTTIITAHRLSAVVHADLILVMQDGRIIERGRHDDLLAQGGWYAKTYESQQL
                     EMEGGEAHA"
     CDS             complement(13883..14089)
                     /locus_tag="ctg17_14"
                     /transl_table=11
                     /translation="MRERGQVWSYSEVKRESQLANYNTDGRYLSETTNFELYNFVREYK
                     TSDEIRRIWNPKKDESVIHDKDN"
ORIGIN
        1 tgcctacatc tatttttaca atcatcaacg ttttcaagag cgcaataacg gccttgcccc
       61 tcttgaaatg aggaacaagg ccgtcgccta atattttatt atttcattgt ccacttgaca
      121 gggagctatt caatatatgt tcaagattat tttttatgtt tatttttatt gacctttttg
      181 aaaaagatat tacctaacaa agcaacaaca aaacctataa taaaatatac catagattag
      241 ctccaccagc aggttgctcc ataggcaaca gtaccacctg caccacctag aacaccacca
      301 gctagataac caggaactga gcctacaact ggtaaaacta cattacctcc aaacgctcct
      361 ccgatagctc ctccgatagc tccttgaaca gtcgctccac ctgcgcctcc ccagctacat
      421 ccaccacctt caacactagc aagtgtttcg aggtcaaggg tgttaaggtt ttcaattgtt
      481 tgagttgcca tggcaactac cccctaaaat ttttatcgtg tgatctctca atcacatctt
      541 tagtatagca ttcaagtgtc tctatcagag ctagcgtccc aaaaagtggc tatatgtccc
      601 gaatggtaat tcctaaagaa catccttcaa tcattggaaa tcttcctcta attttcacat
      661 atttacttaa tcactttctt attataacac ttttatgcaa atatcttata gattgcttac
      721 agaataatca agcaaatgcg tttattgttt aaaatatttt ttgacttgaa ggtaagatag
      781 aaaatcacag aggattaaca aaagcattaa tacggctagt actatacggt ctgtggtatc
      841 actgaatgtt agtaatgtgt aaaactctac actaagcact agaaatgtga tgacaggaaa
      901 gacaatgaag gactgccgta ttgttaacag atttactgaa tctggacgct tcttaagcat
      961 acggtagagc agtccattaa caaaaatgac tacgaaagct agtgctccga ctgttagcca
     1021 agttcctggc gagatcttgc ttttgtagag agaaaggctg atacttataa ggaaaactgc
     1081 caacgcagca gtgatggttc taaaagatcg caatacactc gaactaatat tctttaactt
     1141 catgataaaa cacctaaact atgaataacc tcagtcagtc ttgcaaacct aataagctat
     1201 tacatttaac tctattcctc tctgtatttt attatacagc tgtaagattt caagtaagcc
     1261 cttagcgatt aaattctact ggagatgtaa tacagtagtg tcattagtac tgatacttta
     1321 aataggcgaa tatacatatc tttgttttct ctattacaaa gatatgcaat caaatataat
     1381 ataatctccg ctatcattag caagaataat tttacttcgg gaacatcaaa aataagcatt
     1441 tgcaagcatc ttacgttcaa agtgaccaaa ggttactttt gaaactgtac ccacttttta
     1501 aaaagtaagc tataaagaag caccgttagc cctagcaagt taatggtatg gtgaactgca
     1561 tccaagcttc taaatagatt agcgaggccc attacgatga gaatggtagc cagtaaatac
     1621 ggttttgagt ttttaaacat acttttctcc ttaaagtgtt tttagctagt ctgtgcataa
     1681 tctatgaatt ttattataga ttggaagccg ataaaaaagt agtgacataa atgtcactac
     1741 ttgtctgacc ttatatcctt gataaccgta cacataagaa agagaaataa acataacccg
     1801 ataagattta ggcattgaag tccaaaattc agtttttctc caaagttatg taaggcaaca
     1861 aggacgaagc ccatagacat cattagagac actaggcgtt ttttggtcat gattacaaat
     1921 aactcttctc ttatatcgaa attttcaatc ataattcaca tgctattcac agaccagcaa
     1981 ttgacaagac atttcagtta ggatttcttc ttaacggaag atttcttctt aacggaattg
     2041 gtagccttgt gtttttcaag aaatgacata attggcttat ctaaaaaact cataacagcc
     2101 atggaaacca tccctaaaat ataacttttc aaatcaaaca taatccatca ccaccagcat
     2161 gttgctccat aaccaacacc acctacgata gcacctccag ctgctcctgc gacagcacct
     2221 tgccaagtac gtgttttgat acctagtcgt aaaccattac caactcctgt agctactcct
     2281 tgtttagcaa aacctcccca gctacataca ccaccttcaa cactagcaag tgtttcgagg
     2341 tcaagggtgt taaagttttc aattgtttga gttgccatgg caactacctc ctaaaatttt
     2401 tatcgtgtga tctctcaatc acatctttag tatagcatac aagtgtctct atcagagcta
     2461 gcgtcccaaa aagtggctat atgtcccgag tagtaaaaaa aagactgaat atcatttttg
     2521 attcagtcca tgtcttattg aaaaagcttt aactaattct ttctatactg cctatagact
     2581 ccaaataaaa agaaaaagaa tcctattgat gctaacaaaa gttgatagat atttcctgat
     2641 gacaatagta ctttgctata taaatatatc atcgcaatag tcgaaaaaat gattaggtat
     2701 ttcttcattt gtatcaccta tctcaaatga agattattta gctgtatcat aacaaaatgc
     2761 tgtgctaccg cctgcaaatc cagctcctgc acctgcgatg ccaaagaaag ctgcaccgac
     2821 aatcgtcatt ccggtagtac caataacaca ttgagcacca tagccttgac cacttacatt
     2881 agacaatgca tttgtatcca gttttttaaa tctttcaagt tgtttattat tcataaattc
     2941 ctcccataca aattagaaac agtataaggc tgcacctact aacaccccac cgacagctcc
     3001 ccacgggcca cctactgcac caagtcctcc tactgccagc atcccctcat cacaggacaa
     3061 cccaccctca acactagcaa gtgtttcgag gtcgagggtg ttaaagtttt caattgtttg
     3121 agttgccatg gcaactacct cctaaaattt ttatcgtgtg atctctcaat cacatcttta
     3181 gtatagcatt caagtgtctc tatcagagct agcgtcccaa aaagtggcta tatgtcccga
     3241 atggtaattc ctaatgtata ttatttctaa aattcagaaa aaaaaaaaaa tctcatttta
     3301 tactcataaa aaattgaaaa accgttttct ttatgttaca atttttcaat aaacagtatt
     3361 cgtcataaaa gagaggacta gaccttgaag atttacctat tagaagataa ttctattcag
     3421 atgggtcgct tggaagaggc tgtggcacat gaacttaaat ccttcggaaa agatctatct
     3481 tgtgtccagt cttttgacaa acctgaccag ttgttatcag ctatcacttc taatacaagc
     3541 gatcagattt tctttcttga tattgaaatt aaaggtgaag ataagaaggg acttgatatc
     3601 gctaaaatca tacgtcaaaa taacccttat gctatcattg cctttgtcac tacacatata
     3661 gagttcatgc ctcaagcttt tggcgttaca gcctataaat acatcaataa aaccttagat
     3721 gaagctagct ttagaaaaga aataggggaa accattgctc aagtcttccc tattaacgca
     3781 actaccacgg atgagttttt tctctacaaa acagagtctc aattaataaa ccttcctatg
     3841 gatcaaattc tatacctatc cacatcagat atcaaacacc atgttcacct ccagactatc
     3901 cataccctca tggatatccg agcaaatctg gcagacttta aaaagataca caaaaagctc
     3961 tacccatgcc atcggtccta tatcgtcaat acagatatga tcatctctgt caacaagacc
     4021 aattatgaag ctaccttaat taatggtcaa gttctaccag tatcccgtat gaagatagga
     4081 aagattgcac agattgttga ggaaagaggc agatgatgtt aacaacgtta tggctacttt
     4141 ttctcaccct tttaagtgca ggcctagaaa ttattctttt cctttattta atgggacaga
     4201 agattcgtct gaggtatttt ttcctactcc ttatttttaa tttagccttt aattttattt
     4261 ataaccactc ttcttggttt atcattaaat tctggggtga ggatatctac tatcttctgc
     4321 tctccttcct tttatccact aagactaaaa aaccattaaa aataaagatt ttcaatggtc
     4381 tcttccctga tatcctcaac aaccttagtt taagactgat tacttttttt atctttcctt
     4441 tttttaatat tagtatcacc gattataaaa gctctctatt aatatccatc ccttcatcta
     4501 tcgcacctct ttgtctatca tttctcttta ttaaattatt caaggagagt tttaccatac
     4561 ttcaaaagca gaaatcaaat tctccgattc aacatattat tatagttgct aactttttta
     4621 tgtttgggta caccctactg ttacagtccc tcatgtatct tgaaaacact actcactctt
     4681 caactttgga gcttcgaaaa ctctgtattg ttatttcact tgtcctcttc ttcattatga
     4741 ttgtcttttt agaaagaaac attcgtgaaa tgattcaagg acaattggac ttccagaaaa
     4801 atctccagct agagaatctc tacacctaca ataaacatat tgaatgtctc tacaattctg
     4861 ttcgtagttt tagacacgat tatagtaatc tcttagtcac attacgattg gggatagata
     4921 aagacgatat ggatattgtc aaagaagtct atgatagtgt gcttcaagaa tccgataaac
     4981 gattaaatac aagaaacttt gacttagcta gactcgttaa tattcaggat aatactttga
     5041 aaagccttct gtccgcaaaa gttttacaag cagaagaaga aggtattgaa gctcagatta
     5101 gcatcccaga acccatccac ttgattggga tggagactct ggacttcatt atcgtcactt
     5161 ctattttttt agataacgct attgaaggtg ccattcaaac tcaaaaccct aaaattacta
     5221 ttagcttttg ggaagatcat tgttcacagc tattatctat tagcaatacc ataagtgaag
     5281 aaaaaacaga aaccaaaacc atatttgaaa gaggtgtctc caacaaggga cgagagcgag
     5341 gcattggcct tgctaatgtc acagaaatct tagataacta tatcaatgta aacttagaaa
     5401 cacagagtaa caatttctca ttcacacaac aattaacaat aactaaaaag gcctaacagc
     5461 cttttttcta tacctaagct tgaggaatgt tatagtcttt tgttggaagc gttctttgcc
     5521 ctccgaatcc ttttaggaaa ccatttatat aatccatcca cccacttcca cctacgactt
     5581 gttcaagagc gtggttatca agtgtttcaa agttattaat cgtattgtta gccatcagta
     5641 attctcctcc tattggtctt gcaagtttag taacttgtct ttaaagtaat tgaagtaggt
     5701 cttttggtca ataacgcttg tcacacgacc ttctagaccg taacgtagat tttgggcttc
     5761 tttttctgaa atacttgccc tagcagttac tctaaacaca ttcccccttt ctgtttccgt
     5821 ggcagaatta tcaatactct caagttttcc aataattgtg gtaccgtgat taccaacctt
     5881 atccaaggtc agtcgaactg actggccttt ttgcagtttt ggcacataat ccgaattcac
     5941 ataataagta atggcaactt cctgggtttg agtcatatcg ggataaagct gggccaactc
     6001 agttcctgtc gcagccatgg ttgctttttt atcagcttga ctcaagtgta agattccatc
     6061 ttctggtgac tggatgaggg tattagtcag aaggacatct gcctgattga ttttactctc
     6121 ggtatcgtta atttgtgttt ccactgagct caattgctgt cctgcatttt gcaagaattg
     6181 attttttaga gcttcttttt tagtgctatc actattgtca taagttacaa ctgtgcctgt
     6241 cccagccttt tggatttcta gattacctat ggaagcattc aagctcgaaa tattggtatt
     6301 aacttgagat aggtattggt ctgttacact ggcatccggt gtcgtagcat actgactgtt
     6361 ataggcattt aaggttgcct gatgaggatt gccttcaggt aaagtcgttt catgattggt
     6421 aatagcttga gagagcgcct catactctga gacctgagtc tgcaattgac taatctggtt
     6481 atcaatagca gaaccggtat tactcgcaat tgctgcttgg ttattaacct ctgtatttgt
     6541 tttagccaca cccaagtcaa tatcctgtgc ctgacttagg taggtgttaa aagtactctg
     6601 ataaccaaac tcgtcttcct gttcttggaa aagattggtt ccctgcgtta ggctagattg
     6661 caaggtcttc aaacctgatt cctgtctttt taaaagttct agttgctttt gaagcccctc
     6721 tttttgcgat gcctccatgg tctctgaata ctgaactaag gtgtcccctt ttttaacaac
     6781 cttattagca accagttgat tatctatgat ggtattgtca ctggttgatt ggattactgc
     6841 gataaccttg gttggctcta tacttcctct agacgtgact gtaacttcct tcttagcaaa
     6901 aaaagcgaaa agaaaaagga aaataactaa caaaatcaag ggagtaatca aaacagtaga
     6961 catattgtgg tagcgacgat ggtaaaactc tgtgctttta aacaactgtg gattcatcgt
     7021 gtttcctttt cctcactttc taaataattg ataatagaaa cctggataag acattaggtc
     7081 ttgatgagaa cctgtctcca ctacgcgtcc gtgatcaatg actacgatac ggtcggtccg
     7141 ctcagcgata ctaagcctgt gtgctacaaa gatgatcgtt ttatctttta gtgctaggag
     7201 gttatcaata acctgctttt ctgtcaaaac atccaatccg ctagttgctt catctaagat
     7261 tagtacagga gatttcgtta gtagtgcacg cgccaaagcg atacgttgct tttgccctcc
     7321 agacagacct gctccatcag acagctctgt ctgaaacccc ataggcatgt tttcaatatc
     7381 ttgacgaatt tctgctattt cacaagcttt caaaatatca gcttgcgtaa taccccgtgc
     7441 tgcacctaaa gtaagatttt ctaaaacact accactaaat atataggatt gctgagggag
     7501 atagttaata tgttgacgaa gagttttctt gtctatgcga ctaatatttt gaccattaaa
     7561 atctatgtgc cccttatatg gttgataaaa attgaccaac attttagcta gagtagtctt
     7621 accagatcca ctgacaccaa caaaactgat tttttctcct tgtctaatcg tcaaactgac
     7681 atcagtcaaa gtatcacgac caaaaccata tttataagat aaatccgtaa cagtgatatc
     7741 tccatccgca atgccttctt gataggtatc atcactttgt ccaaactctg attcaatcag
     7801 atagacctca ttgagcctag tattagctac cttagcagac tgtaacttgg tttgcaggtt
     7861 aatgatattt tccaaaggat tcgtgaagta agaaagcaac atattaaaag taatcaattg
     7921 tcctatcgaa atggtatttc ccatcaccaa ctgagcacct gtccagagga taagtacatt
     7981 taaaataagt tgagcacctt gtttcaatga tgtttgtagt atagataact tagaaaggcg
     8041 aaaagaattg tctagatagt caataaactc accatcaatc ttttgatagc atacttcttc
     8101 gctggttagt gactttatgg tttcaatccc attaatgtcc tcaatgatgg ctgaattaac
     8161 catagcatta ctctgcatga cgtcatgatt cattcgctca aaaggtttca taaaggcaaa
     8221 gacgataagg gtataaattg gaaccgaaca aagaactagc ttgaagagat tgctattttg
     8281 tatcaataac acgcctccta cgataatcac aatagagaaa tcaaggaaaa gtgataatat
     8341 cgtcgaagcc agagcatcga taatagagtt agcatcacta aaacgtgaga taacctcccc
     8401 tgtacgtctt gtggcaaaaa aagacattgg gagttcaaag atatgtcgta tgtaggacaa
     8461 gataacgtca atggtaaatc gctgactcag tatggttaag agataatctc ttgcaaaagt
     8521 catcatttgt tgtaaaacat aggtcacaac taatccaatt gagataattc ctaaggtaga
     8581 cttcatttga ttagggacat attcgtctag aataccttgt aaataatagg aacctaaaat
     8641 atttattaaa gtaaccaaga gactggcaaa gacaatatta gctatcaagg acctttgttt
     8701 aaagatcaaa gggagaaagt cccagagtcc atttttctta tccttatgtg gtttataact
     8761 gggttccggt cccataaaaa gagtaacacc tgtccactct ttctcaaaac gctctttagt
     8821 cattttagtt acttttacac ttggatcagg gtctccaatt atcagataat ccttggtgct
     8881 tttataaata acataataat gttgaagctt cccatcttta ttaacatgag caataaaagg
     8941 ataaggaaca tcttccatct caaagagcga catttcagcc tttatagctc tcgtttcaaa
     9001 gccaattttt ttagcagcct ctacaagacc taaggcagtt gtcccttctt tattggtctt
     9061 cgccaactca cgcagatgtg ctaatgaata atctgaacca tagtacttgg ccactgatgc
     9121 caaggcagca actccacaat ccctcatatc tatttgaggg acaaaagtcc tacgaaaacg
     9181 aaacatacca aaccctttca tcacaaatta tcatatgatt agtatgtcat attttcagga
     9241 taaaaagagc cagcgtccca aaaagttgcc atacgtccca aacggtaaga aaaatcttaa
     9301 agtcatctcc actattacca tttaagccgt atttggggtc atttaggaca agttcattga
     9361 aatcgatttc aaagttatac aatagttatt agaaggaaac attctaaaat agtcctacaa
     9421 gcatacgtat ttgatctaac cattattact gtgccagccc tggtatttcc aaaggaaacc
     9481 atgactgctg atagcctcgg agcctatctc tatcgtatga tgtcataatt tgattatttt
     9541 tattccgaaa agggataaca ttatgaaaaa cgtcaatcca tatctcaaaa aatcctatca
     9601 aaaaaggcta aatcagcctc ttgagattcg attactcaat tatcggttta attttcctta
     9661 gctttgtaag tgtatttgtt atcactgtca atgctatttt tagcgtcact agaggggttc
     9721 ccttccttaa tgcccacctt atttccacct tgagtaattg tgccttctat cttttgattt
     9781 actcaacctt gaggtggcac catctcaaaa agctctataa tctctacagt ggtttttccc
     9841 actacagaaa ttatagagcc gaagttaagt agttctgtgg taaactgagt cataggaata
     9901 aatctctttc tagtaatgtt ttgcaactct actataacgg atttattcct ttttgtgttt
     9961 acacaactta ttttacacta cctcaacgtt tgcaagtacc tcgagatcga gtgtttcaaa
    10021 tgtattattt gtttgccttg tcattctaac aacctcctaa attattttta gctttttctc
    10081 tcaagctatg attttattat agggtggtag ccaacaaaaa agtagtgaca taaatgtcac
    10141 tactcgattt tgatttttaa gaaatctttt cgaatataga agctatggtc tagattagct
    10201 tactctcctt ccatggcgcc tgcttgtagg ctgtacatct tgtgataggt gccgccgagg
    10261 gctaggagct cttcgtggct accatgttca atgatgcggc ccttgtctaa gacatagatg
    10321 cagttagcat cttggattgt tgataggcgg tgggcaatgg caatggttgt acggccttga
    10381 cgcatttttg caagagagtt ttgaacaata gcctctgtct ccgaatcaat attggctgtc
    10441 gcttcatcca aaatcaagat tttaggctgg ctagcaacgg ttctagcaaa ggctagaagc
    10501 tggcgttgac cggttgagaa acttgaacca cgttcggaaa ctggggaatc atagccttct
    10561 ggaagtttat caataaagtg attggcatcg acaaactcag cagcagcttt aatctcttca
    10621 tcagttaaat cttgatacat ggcaatattg gatttgattg tgccatgata gaggaagggg
    10681 tcctgaagga caagaccaat attcttgcac agctctgcct gactataatc acgaatatcc
    10741 acaccgtcta tgagaactcg tcctgattgg aattcataga atcgcatgag cacgttgata
    10801 atagaggatt ttccagagcc tgtagatccc acaaaggcga tggtttcacc tttattgaca
    10861 gagaaggaaa tattatccaa aatctggtgc ttgccatcat aggagaagga gacattctca
    10921 aagcgaatat tcccctcagt aaccttggca gctgtgtctc tctgttcagg ctcataggta
    10981 cgctcgtcaa tcaaggcaaa gacccgacct gctgagacca tagaggtttg tagagtcgag
    11041 aagttttgtg tcacttcaat caagggatca aagaggcgat taatatactg gataaaggca
    11101 tacatggtac ctgctgtgat acccagatag atacctcggt agccaaaata ggccatgaga
    11161 acagcataag ccaggagctt cagtagactc atggctgggc gtagaaagag agaatccagt
    11221 gatatagaac ggctggcata aatcaggtgt tcctcattaa tggcatcaaa ctctttttta
    11281 agacgcttct cctggttaaa ggcctgaatg atgtgaatcc cttcgatact ctctgacagt
    11341 ttggcattta tatctgaaag caaggctctg gtcttttcaa tgatggccac tgattttttg
    11401 cgataaaggt taaccaaaag gacaatcaga ggaagaaaga ggacaataag cccggtcaga
    11461 cgaatgtcca agatcatcat ggtgtaaagg gtggtaacaa agataaagat agccgaaata
    11521 aaactagaca gagttcctga gaacatctcg ctaatggtct cagtatcatt ggtcaagcgg
    11581 gaaacgatgg aacctgctgg ggtcttgtca aagtaagaca tacccagttt ttccatattg
    11641 gcaaaggcat ctcgacgaat atctctgaca atgctatagg acacacgcgc aaagaagaga
    11701 tttcccagat actggactag tgtctgcaag aggtagagac catagtagcc aatcagaatc
    11761 atacttgccg cctgattcat atcatgaaga tagtgatcaa taaaataaga ggccaccaag
    11821 ggaatgatac tcttgataac cgttgtggac aagaggaagg tcaaagctag aaaggtcaag
    11881 aacttgtaag gcttgagata ggtcaagaga cgcttaaaca cagaccattg gttttgatta
    11941 ggcatgagct tctcctcctt ccatttctaa ctgttgagac tcataggtct tggcatacca
    12001 accaccttga gctagtaagt cgtcatgacg cccacgttca atgatacgac catcttgcat
    12061 gaccaggatg aggtcagcgt gcaccaccgc actgagacgg tgggcggtaa taatagttgt
    12121 tttgtccttg cgagtatgct taagattatc aataatggca tgttctgtct tagcatcaac
    12181 cgcagataag gagtcatcca aaatcaaaat ttctggattc aaaatcatgg cccggctcat
    12241 agccagacgt tgtttttgac cacctgatag gctgacaccc ttttcaccaa tgattgtttc
    12301 aaagccttca ggcatatcct tgatatcatc ataaacttga gctaacttag tcgcttcttc
    12361 caccttatca atggagaaat ctggattacc aaagcggata ttgtctaaaa tagaactggc
    12421 aaagagaaac tggtcttgag gaacataacc aatcaagcta cgcaagtctg ataggcgata
    12481 gtctcggatg tcatgtccat tcaaatagat ggctccttga ttgacatcgt gctcccgcaa
    12541 gagcaacttg acaagagccg tctttcctga gccagtcggt ccaaccaaac caagggtttg
    12601 ccccttgtcc aaggtgaaat gaatatctcg caaagtatcc tcatcctcaa aagcaaagcg
    12661 gtcaatcgca aagtctaaac gaccattttc aatgcttgga agaggataag cgggatcttg
    12721 aacatctgat tcctgctcta aaagagtctc gatacgttgg taggacacat ttcccctctg
    12781 cgtgatatta aagaggaagc caatggccat taggggccaa accagcatgt ccaaataggt
    12841 aataaaggtt accaaatttc cgaccgttat ctgaccggcc tgaatcataa aggccccgac
    12901 aaggagggtc aaaacataag atgagccaac aaagagcaag accaaaggat caaaaaggct
    12961 gtcatacttc atggtatgca tattcttttc aaaagtcatc ttattggtct cttggaagga
    13021 ctggagctca gcctcctgat agccaaaaga cttggttacc ttgatacctg acaccgattc
    13081 ttgtacctta ttattaagtt cagaaaaagc tgcctgggat tctccaaaag ctttgtgggt
    13141 cttacgtccc aaacgactag tcgcaaaagc catgaaaggt agaggtaaga ctgccatcag
    13201 ggtcatctgc caggaaatgc tgaagaacat ggtgattaaa gtcaccaagg ctgtgataga
    13261 cgcatccacg gctgacatga cacccccacc agccaaacgg gttagagagt tgatatcatt
    13321 ggtggcatgg gccatgagat caccagttcg gtacttttgg taaaaagaag gcgacatctt
    13381 ggtaaaatgc tcaaaaagcc gcgaacgcat aatctgtccc aagcgataag acgttgccaa
    13441 gatatacatc cgccaaacat agcgcaaata gtacattcct aaagccgcca aaagcaaata
    13501 aacgagattc aaaagcaaga tctgattggt caattttccc gatgtgatag catcaatgac
    13561 ccgacccata accataggag gaatcagatt gagaaccgaa accaaactca gtgccagtat
    13621 cccgacaata taacggcgtt tttctaactt gaaaaaccac caaagttttg caatgattga
    13681 ttctttaaaa aacaagttat tccccctatc cctacaaaag gatgattata agtctaatga
    13741 aagttatttc caatagcgat aaattgtacc atcttctaac tgaaagtgac caatataagt
    13801 caattttcca aaatcagtag actctggcaa ttgataagca aaggagtcaa aattatagac
    13861 cttgtgccca tcatcaatag aatcagttat ccttatcgtg gataactgat tcgtccttct
    13921 tagggttcca aatacgtctg atttcatcag atgtcttata ctctctgaca aaattgtaca
    13981 attcgaagtt agttgtctca ctgagatagc gaccatcagt gttgtagtta gctaattgag
    14041 actctctttt aacctcagaa tagctccaaa cctgacctct ttctcgcata atatcggcat
    14101 cacggccact tttgataagt atctgcttta accgctgtca ttgttgctcc tagtgtcaat
    14161 acagtgacta ctgtcacatt aagtgt
//
