LOCUS       c00007_JAJQWR0..       17331 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJQWR010000016.1 Streptococcus thermophilus strain 8253 (205)
            NODE_16_length_41697_cov_368.063398, whole genome shotgun sequence.
ACCESSION   JAJQWR010000016
VERSION     JAJQWR010000016
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:57:07
            Original ID  :: JAJQWR010000016.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 12149
            Orig. end    :: 29480
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17331
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[17149:24480]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..12331
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..17331
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17331
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(661..1275)
                     /locus_tag="ctg7_14"
                     /transl_table=11
                     /translation="MWKWFKRLLILVIVLFLAVVALLIPDNIDSQDQLKNVSTQTSLVD
                     LAQAGIGGASLSSGGLSTEINLDSNQFRQVLKASIAESNDETLQNSTVELNDSYLTAKV
                     PVSLGPIESTFSLDFTVSTNKEVILLDLAGAHLGRLPVPKSLVLPYLKKSIAQSSSGVR
                     MVNNQIQIKLPEIGYEIDQATVTNGKMKVRLNIPMSLPTSW"
     CDS             1547..1702
                     /locus_tag="ctg7_15"
                     /transl_table=11
                     /translation="MLDKFIRIQTTDASIIDDIVDTSTPSKFTKGKKLHERGDNEEHLP
                     LDDDLI"
     CDS             complement(1869..2330)
                     /locus_tag="ctg7_16"
                     /transl_table=11
                     /translation="MMRYLGNKTKLLTFIEKVIDKYKIEGETFADLFAGTGSVGDYFKG
                     KYTVYSNDYMYFSKVISEAKLSNFKTPDFKEFHKKYGVSPFEWLNKKQYKTEKSYFTYN
                     NYTPLADRMYFTEDNALNIDGMRLDIEELFHEGYISKAEYSYLLASLLD"
     CDS             complement(2327..2548)
                     /locus_tag="ctg7_17"
                     /transl_table=11
                     /translation="MGFSYERLWELTLKRRINKTSLRDMVGITNSTLSRLSKDETVSME
                     ALARLCEALQCQLEEIIEYKLENKDRVE"
     CDS             complement(2716..3546)
                     /locus_tag="ctg7_18"
                     /transl_table=11
                     /translation="MKQIFIFSDSQKDNISYFEREPAMLVSMNRSDLPYLKEQDFASHT
                     AIYVLIGGNKRYVGQAAGQTIYQRLYQHFSKEDKKWVESVLFFSRTDGKLSKADTDYLE
                     KRLIQDFTEKSDYQMMNSTIGNKSYIGKLPKAQSDQLYETVFEIIDDIANIDLFGVSEG
                     ELTNEVSPSDMFEIQYDGHTLQSKSARGLFVDFVKSMLVDDKYKQQIEELIAPNAPTAG
                     VVLGRKVSTYNGRPISAEVAPGVWLFTNFSRKDTKNKLEKLTKQLGISAKINWK"
     CDS             complement(3751..4380)
                     /locus_tag="ctg7_19"
                     /transl_table=11
                     /translation="MEAYRQLYHSNENLMTDLLETIESELNDNSLNKELKRITNKLRTL
                     LKKEENLVNLRLEGKISDTIYNEKYNEISSEKEFLAEEKVNIETTLKSEIDVKKRLTEF
                     KHLLSSQKMLTEFDRAVFESIVEKIIVGGVNSDGEIDPAMLTIIFKTGETQNKDGKQFK
                     SKRKNAKLETDKLCPQNSDEDKKLYSQGTDYTHRVCRSAHSCGTVI"
     CDS             complement(5001..5195)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_20"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.9e-12,
                     bitscore: 39.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQYNGFEVLHELDLANVTGGQINWGSVVGHCIGGAIIGGAFSGG
                     AAAGVGCLVGSGKAIINGL"
     CDS             complement(5212..5469)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_21"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.7e-21,
                     bitscore: 68.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTITICKFDVLDAELLSTVEGGYSGKDCLKDMGGYALAGAGSGA
                     LWGAPAGGVGALPGAFVGAHVGAIAGGFACMGGMIGNKFN"
     CDS             complement(5677..5853)
                     /locus_tag="ctg7_22"
                     /transl_table=11
                     /translation="MKRVLKLTLYGSLELYLNVYLLDKYGLESWVYWLSLVLSLLLMYW
                     LDKLFWSDKTWCF"
     CDS             6355..6678
                     /locus_tag="ctg7_23"
                     /transl_table=11
                     /translation="MYNTFLINSSLLVSNINVYLQAIIAPAAAPTAVPIAPANRPPASP
                     LLPPQNAPPAIVATQRVETPPSTVARESVLSTLNCSIDFVFITNTSLYNIFICPVATST
                     SLA"
     CDS             7305..7595
                     /gene_functions="other (smcogs) SMCOG1164:transposase
                     IS3/IS911 family protein (Score: 60.5; E-value: 2e-18)"
                     /gene_kind="other"
                     /locus_tag="ctg7_24"
                     /transl_table=11
                     /translation="MSRKIRRHFTDDFKQQIVDLHTASMKRSALIKEYDLTPSTFDKWV
                     RQAKTMGSFKSIDNITDEQRELIALRKRNKELEMQIDILKQAAVIMAQKGN"
     CDS             7631..8164
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 124.6; E-value: 7.1e-38)"
                     /gene_kind="other"
                     /locus_tag="ctg7_25"
                     /transl_table=11
                     /translation="MCRWLNLPRSSYYYKTSEPVSEADLEEKVKQIFLESQSRYGARKF
                     KQCLATDGIILSRRRIRRIMKRLNLVSVYQQASFKPYAKGKNEAPIPNLLDRQFHQEKP
                     LEVIVTDLTYVRVGQRWAYVCLIIDLFNREIIGVSVGWQKTAELVKQAIQSIPYALTKS
                     IFSILTVARSLTIN"
     CDS             complement(9188..9406)
                     /locus_tag="ctg7_26"
                     /transl_table=11
                     /translation="MKLLFFITVIFVQLYSVYTDWKSKHLIEKSIDLSVINVFIILFLI
                     YKKLVFIWIVYLLIVINFFLRINEKRN"
     CDS             complement(9409..9612)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_27"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.4e-13,
                     bitscore: 41.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNYKILDEGILQKIEGGNPAGAAVVAGMGCAATGIKYGSKLGVW
                     GAAIGGVGGAVVCGYLAYTAVG"
     CDS             complement(9627..9881)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_28"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 5.9e-21,
                     bitscore: 66.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKSMEQFKQMDVEMLASVDGGKNNWQNNVLEGVGAATAGWGLG
                     TTICTVTGVGAPLAPACGYIGAKFGVALWAGVTGATGGF"
     CDS             10178..12331
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     253.2; E-value: 3.1e-77)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 316.7; E-value:
                     5.2e-96)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_29"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1135.5,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.2e-45, bitscore:
                     145.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSYKRTFVPQIDARDCGVAALASIAKFYGSDYSLAHLRELAKTN
                     KEGTTALGIVKAAQEIGFETRAIQADMSLFDMNDVPYPFIVHVNKEGKLQHYYVVYQTK
                     KDHLIIGDPDPTVKVTKMSKERFSSEWTGVAIFLAPEPSYKPHKDKKNGLMSFLPLIFR
                     QRALIFYIVLASLLVTLINIGGSYYLQGILDEYIPNQMKSTLGIISIGLIITYILQQMM
                     SFSRDYLLTVLSQRLSIDVILSYIRHIFELPMSFFATRRTGEVISRFTDANSIIDALAS
                     TILSLFLDVSILTIVGGVLLVQNTNLFLLSLISVPIYIIIIFAFMKPFEKMNNDVMQSN
                     SMVSSAIIEDINGIETIKSLTSEESRYQKIDSEFVDYLDKSFKLSKYSILQTTLKQGAQ
                     LILNIVILWFGAQLVMNGHISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRL
                     NEVYLVESEFSNSQTLTDSQFLTGDIRFEDLSYKYGFGRDTLSDINLTIKQGDKVSLVG
                     ISGSGKTTLAKMIVNFFEPYKGRITINNNDLKLIDKKTLRQHINYLPQQAYIFSGSILE
                     NLTLGANQLISQEDIIRACEIAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARAL
                     LTKAPVLILDEATSGLDVLTEKKVIDNLMAMADKTIIFVAHRLSISERTNQVIVIDQGK
                     VIETGSHHELMTKQGFYHHLFSK"
     CDS             12343..13704
                     /locus_tag="ctg7_30"
                     /transl_table=11
                     /translation="MNPNLFKSAEFYQRRYHNFATHLIVPLILLVGFLLTFSLFAQKEV
                     TVTSRGEITPTTIIASIQSTSNNPITTNNLANNKLVKKNELIIQYAETMESSQKQALET
                     QLATLNRQKTGLETLKESLSQGTNLFTGEDEFGYINTFNNFITQSQDIELGISKTNAEV
                     SNQAALAGNTIAAIDTQINQIYHQIAEYEELRQAITNRQTSLSADNPHQATLNNFLAQS
                     QQDSQTGLTDQYLFQINQSISGLESSIASLNIQRAGTGSVATYDNSFVTKVEVLRTQFL
                     QSASQQLTTLETQITELVAQLEQASVRLENNTITAPETGVIHLNSEFEGKSLIPSGSEI
                     AQIYPNINQTKEFLITYYVTSEHVALLKEKQDVRLSLEKVGNQSITVVGKIKSIDKTAT
                     KTEEGNLFKVTALAQLSDKHSDVIQYGLQGRVTSIIAKKTYFDYYKDKILSNHD"
     CDS             13803..13958
                     /locus_tag="ctg7_31"
                     /transl_table=11
                     /translation="MTKHRTSLTAFTELSPSELHRISGGDWWSDWMKYFPKSKQAIDSN
                     NKHKLG"
     CDS             complement(14006..15346)
                     /locus_tag="ctg7_32"
                     /transl_table=11
                     /translation="MSVLNYIIEAIVSLGSLIVLFFSVNRLKYSIRSILLVILLRVSVA
                     ALFATLSQLFSSQFFSYFDTPLYGLLLAIVFLRPLSKTLLIFCGLFPFILENLFYRMVL
                     YFIFPLFGQTPGIIEDTPTFVFVNLLSTLSVLFFLGWLRYDFVKLRTDNLVAEDKRILY
                     MTNWVMLAYYLLMQTLTYLEYDIGLPTMAYRQFILVTYLVIFMGIIKQLDLHLREKIQE
                     QFDFQQALQLKNLEDYSNQIEELYREVRGFRHDYSNLLTTLRLGIEENDMVQIKDVYQS
                     VLKDSHKQLRASKYDIGRLVNIDNSALKSLLASKFLQANDNHVAVSLEVPEAIKPQGMK
                     LVDFITIVSILCDNAIDATKGTFGKITIAFLSVDNKQMFIIENNTKEEKVDLSELYAFG
                     HSSKGEGRGIGLYNVMKILERYPHVSLNTTSASYLFGQSLEIDLSSK"
     CDS             complement(15357..16097)
                     /locus_tag="ctg7_33"
                     /transl_table=11
                     /translation="MNIFVMEDDFMQQARIEKIITKLLEKHNIVPKKFEISGKPHQLLQ
                     AIEEKGVHQLFFLDIEIKEDELKGLQVAKQIREIDPYASIVFVTTHSEFMPLSFRYQVS
                     ALDYIDKELGVTEFESRIEAALLHTHNKDNSAVSDDSFYFKSKYAQVQYPFNEVYYIET
                     SPRPHRVILYTKTDRMEFTASLSDILKQDKRLVQCHRSFAINPRNVVKVDRNEKQIYFP
                     NGATCFISRQKLESTLAVIDRLHR"
     CDS             complement(16099..16440)
                     /locus_tag="ctg7_34"
                     /transl_table=11
                     /translation="MNFMIIKVKDETKKVLLSDILYIISHPSKPHYIQIVTEKEIYDCL
                     QKLQSIEELYPECFIRCHRSSLVNRSKIKVINSREKRIFLGEKGEHCLTFSRRRYQDIL
                     HQWINKGGM"
     CDS             16639..17034
                     /locus_tag="ctg7_35"
                     /transl_table=11
                     /translation="MIEIFPYSPLSIFIAIVIKGYLISHQIYSKIKLSFSYYPYKYDSP
                     TTYFIIKSKFLTSEKMNNYLKNVRDYSELATIIIIGKNIDYEELFKNHYRVFGVIDTTE
                     NKSLTFIRDQIHFYLDGLYGLKKKESD"
ORIGIN
        1 gcatagtctc ctactgatga atttccgtca tcactagcat catcgaggta actaatccca
       61 cggtgtttca ccatattttt aagagcgata aacagttctt cattagacaa ttcatcggtc
      121 aagcccttaa ctcgtaattg atatgggtta agattaattg aaatcttcgt aaaatcggtg
      181 attaatccac tttcctcaaa tagacgattt aaacgaacta tacgatgttt tttacgtcgt
      241 gtcaagcgtc ttccttgacg attcgttcta cgtactaggt tattttccgc ttgagctgct
      301 gggaagatgc gtgagttttt atggataatt tctcctgtca ctttgttaag gatacctaca
      361 ccaacagaac ctataccgat atcaagtcct aaaactaagt cactcattta ataatctcct
      421 tatgcttttt tctaatatta taaactaata tctgaaaatt cacaactttt tttgtaaacg
      481 ctataatata tgttttaaaa aatcaattta atatcatttt tatctaaaca acgttattca
      541 cttcattccg aaacctagaa aaaatataag tagtcctccc tctaacgact ttgctcatgt
      601 aaaaaaccaa gtcagcttag acttggtttt ggattttatt tttgaacaaa tgattttaaa
      661 ctaccaactt gttggcaagg acatcggaat attaagcctc accttcatct taccgttggt
      721 aactgtggct tggtcaatct cgtatcctat ttcaggaagc ttgatctgga tctggttgtt
      781 aaccatacga acaccactgc tagactgggc aatactcttc ttgagataag gcagaaccag
      841 tgattttgga actggaaggc gacccaggtg ggcacctgcc aaatctagta ggatgacttc
      901 tttgttagtg ctgaccgtaa aatcaaggct aaatgttgat tcgatagggc caagagatac
      961 gggaacctta gctgttagat aggaatcatt caactctacg gtactgtttt gcagggtctc
     1021 atcattagat tcagctatgc ttgcttttag gacttgacga aactgattac tatcaagatt
     1081 aatctcggtt gaaaggccac ctgatgatag ggatgcccca ccgataccag cctgggctaa
     1141 atcaacaaga gatgtttgtg ttgatacatt ttttaattgg tcttgactgt cgatattgtc
     1201 cggaataagt agagccacca ctgccaaaaa gagcacaatg acgaggataa ggagtcgctt
     1261 aaaccatttc cacataggga tacctcattt caatttttca cttttgacgt ctattgtact
     1321 gtaatcaagg gaaaaaagcg agtaagaact ggaaattctc tcatattttt ttaatccaat
     1381 aggtagggtt caagagcttc atagactttt aagtagatat tggcatatag gtgaacgccg
     1441 tcatatggtg gaaccactgg tttccataag gtctcctcgg ttatatcatt agtaccgata
     1501 ttgctgaaaa ccttagtcgg tctcaaatcc aaaagcaggg atggatatgc tggacaaatt
     1561 catccgtatt caaaccactg atgcctcgat tatagatgat atcgtcgata cctctactcc
     1621 tagcaagttc acaaagggga aaaagctcca tgagagagga gacaatgaag agcatctccc
     1681 ccttgatgac gacctcattt aagtactgat agtttttcag tttggtttct tatgtgggaa
     1741 tatatccact taacctttta acgatagtat aaagttatcg ttaaaggtat tacctcgaca
     1801 aacttagggt tatctatctc actctttttt caaatcttaa gaagaaatct ataagagcat
     1861 ctagcaattc aatctaataa tgatgctaac aaatacgaat actctgcttt tgaaatatag
     1921 ccttcatgga acaactcttc tatatcaagt ctcattccat caatattcaa tgcgttatct
     1981 tccgtaaaat acattctatc agcgagaggt gtgtagttat tataggtaaa ataacttttt
     2041 tccgttttat actgtttttt attcagccat tcaaatgggc ttactccata cttcttgtga
     2101 aactctttaa aatctggtgt cttaaaattc gaaagctttg cttcacttat tactttagaa
     2161 aaatacatat agtcatttga ataaaccgta tatttccctt taaagtaatc tcctaccgaa
     2221 ccagttcctg caaataagtc tgcaaaggtt tctccctcaa ttttatattt gtcaataact
     2281 ttctcaataa aagttaacaa ttttgtctta tttcccaaat agcgcatcat tcaaccctat
     2341 ccttattttc aagtttatat tcaataatct cttctagttg acattgaagt gcttcacata
     2401 gccttgcaag tgcctccata gaaactgtct catctttaga taatctagat aatgtcgaat
     2461 ttgtaatccc aaccatatct ctcaaagatg ttttgttaat tctccttttc aacgttaact
     2521 cccacagtcg ttcataacta aaacccatgt agttcctccg tccacaaaag tggaatatta
     2581 ttctataaat atagaattgt tatatcacag aatgccactt tataattaac cgttttaaac
     2641 ttattatgta cttttttgga gttttgagtg ataaaaaggc actctaggga attattcacc
     2701 agagtgcacc cgtcattatt tccaattaat tttagctgaa attcctagct gcttagttaa
     2761 cttttcaagc ttatttttag tatcttttct tgaaaaattt gtgaatagcc atacacctgg
     2821 agccacttct gctgaaattg gtctgccatt ataagttgaa acttttctac ctaaaacgac
     2881 tccagcagtt ggtgcatttg gcgctattaa ctcttctatc tgttgtttgt atttatcgtc
     2941 gacaagcatt gattttacga aatcaacaaa cagccctctt gcagactttg attgtagtgt
     3001 atgaccatca tattgaattt caaacatatc tgatggacta acctcattcg ttaattcacc
     3061 ctctgaaaca ccaaacagat caatatttgc aatatcatca atgatctcaa aaacagtctc
     3121 atacaattga tctgactggg cttttggaag cttcccaata taagatttgt ttccaatagt
     3181 tgaattcatc atttggtaat ctgatttctc agtgaaatct tgaatgagtc gcttctccaa
     3241 ataatcggta tcagcttttg ataatttccc atctgttctg gagaaaaata aaactgactc
     3301 aacccatttc ttatcttctt tagaaaagtg ttgatataac cgttgataaa tggtttgacc
     3361 tgcagcttgc cccacgtagc gtttatttcc accaattaaa acatagatag ctgtatgact
     3421 cgcaaagtct tgttctttta gataaggcaa gtcactgcga ttcatggaaa ctagcattgc
     3481 cggctcacgt tcaaaatatg aaatattatc tttttgtgaa tctgagaata taaaaatctg
     3541 cttcataacc ttatctccca tggaatttcg ataatatatt atatcacgta accgttacca
     3601 aaatcatcta agctatcaac tctacggtgt aaaacccgtc aactcaagga tccataacat
     3661 ttctgtcaac tctacggttc gccatgaaaa agtcattttt acacggaaaa agggcaatcc
     3721 gagaattccc ccgagctgct caaaacctta ttatatcacc gttccacacg agtgagcaga
     3781 cctacacact cgatgtgtgt agtctgttcc ttgagaatac aattttttat cctcgtcact
     3841 gttttgagga cacaatttat ctgtttctag tttagcattt ttacgtttac ttttaaattg
     3901 tttaccatcc ttgttttgag tttcacctgt tttgaatatt atggttaaca ttgcaggatc
     3961 aatttctccg tcgctattaa ctccacccac aataattttc tcaacaatac tttcaaaaac
     4021 tgcacgatca aactccgtaa gcattttctg cgaagatagc aagtgcttaa actcagttag
     4081 tcttttcttt acatcgattt ctgattttaa ggttgtttca atatttacct tctcttctgc
     4141 tagaaactct ttctctgagg aaatttcgtt atacttttca ttgtatatgg tatcgctaat
     4201 tttcccttcg agccttagat ttacaagatt ttcctctttt tttagtaatg ttcgaagttt
     4261 gtttgtaatc ctttttagtt ccttgttaag gctattgtca ttcaattcag attcaatcgt
     4321 ttcaagtaag tctgtcatta agttttcatt tgaatgataa agttgtctgt aagcttccat
     4381 gaaagccccc tcaatagcga gcttttctaa tcctttcact aatatttttt gtctaacttt
     4441 ttggggtcag tacactatta tagtcagtat ttttaaataa tggtatgttt tagagtctac
     4501 tttaacaata aactttaaga atattaaaga gagaattgca atgcttagaa gcagaaaaat
     4561 cttatttcta atctccaaca taatgagcaa atactgaacc cccaatttgg gtttcctcct
     4621 tgaatttctt ccaagacgaa ggtatttaat tcaatatgtt tatcaaaatt tcatatcaat
     4681 atcagcctcc aaatttattt cctatgtctg ttttttatca tgagatatct tttgtataac
     4741 tattcaaccg ttcaagatga atactttgct gtacttgact tgataatttt tggggaggtt
     4801 aaaaacattt agcatacttt gaaaatctac aaatagacca aaatcgaatt tctcaatcaa
     4861 aaatccagtc taaaagataa ctgcataata gatagataag aggagctacc ccagcaatga
     4921 ttagtttctg attattcttt cgaagaccga ttagtataac tacaagggga attatgaata
     4981 ataaaaacga taaaagactt ttataatcca tttatgattg cctttccgct cccaacaagg
     5041 catcctactc cagccgctgc acctcctgaa aatgcacctc cgataatagc tccacctata
     5101 cagtgtccta caactgatcc ccaattaatt tgaccgccag ttacatttgc taagtcaagt
     5161 tcatgtagaa cctcaaaacc attatactgc ttcatgatat aaactccttc cttagttaaa
     5221 cttattacca atcattccac ccatacatgc aaagcctcct gcaattgccc caacatgagc
     5281 tccgacaaat gcacctggaa gtgctccaac acctcctgct ggagctcccc aaagagctcc
     5341 acttccagct cctgccaatg catatcctcc catgtctttt aaacaatcct taccagagta
     5401 tccaccctca actgtcgaaa gaagttcagc atctaaaaca tcaaatttac aaatagttat
     5461 tgtattcatt gtaaatatct cctacctaat atttttattt tgtcgggttg caaccttgac
     5521 aagtctagta tagcactact tcaaaaaata atttccccat ttcttgaaca gtcatttaac
     5581 tttcctaaat gggaaaattt accgttactt atttatatta ataaaccaaa tcaaaagtca
     5641 caccaataat ttatattagt gtgacgacaa acaatattag aaacaccaag ttttatcgga
     5701 ccagaaaagc ttatctagcc aatacattag taacaatgat aaaaccaaac tcaaccagta
     5761 tacccaactt tctaagccat acttatccaa taaatagaca ttcagataga gctctaaact
     5821 tccataaaga gtcaatttaa gaactcgctt cattcgcacc ctttcctcta gattttttaa
     5881 tttattatga gttaaattaa caagctggta aaactttcct tggataggct gggatataat
     5941 ctacacaatt agattgtgga ggatgaacaa ttgtcatccg actttttata tatctcttaa
     6001 atgctatctt ttgttttttc tatacggaat aagaagtatc aaacaaaaag ttagtaacga
     6061 tcctaataac aagacgtagt ctttgaatgt ttttggaaaa attggaaaaa taattactat
     6121 caaaaagcca aatgccatta taaaagcagc taaattaaac tttctcactt ttatgaacct
     6181 atttgcataa agcaactgca gcacctactc ctgccattgc cccgccaaat acacctaagg
     6241 ggccagtaag tgctgcccct gcgagaaatc ctcctcccgc tgctgccata actccccaaa
     6301 cacaattatt ttttgaagct cctgcagaaa tatttactag ttctacctct tttaatgtat
     6361 aatacatttt taattaattc ctctctttta gtcagcaata ttaatgttta tctacaagca
     6421 ataattgcac cagccgctgc cccgactgct gtaccaatag caccggccaa tagacctcct
     6481 gctagtcctc tactaccacc ccaaaatgct cctccagcta ttgtagcaac acaacgcgtt
     6541 gaaactccac cttcaacagt agcaagagaa tcagtattaa gcacgttgaa ttgttccatt
     6601 gattttgtat tcataacgaa tacctcctta tataatattt ttatttgtcc agttgcaacc
     6661 tcgacaagtc tagcatagca cttcctcaaa aaatagttcc cccatttcct gaacagtcat
     6721 ttaactttcc taaatggcaa aattttgtcg ttgaagatga tgtaatgacc attcgagaat
     6781 tatttttagt ttgagtcaat atctcttttt ttccatcctg gacgtttcca tgaccattta
     6841 agatttggac gcttttttct ttattttgga ttgaaagaaa ttatctatct tcttcgcaca
     6901 taaaataagc attaaaaata taccgaatag taatagatca attattgttg tattgggaaa
     6961 aaaataacta gaaaaatctt tacactaaaa atataacaat aatataaatt tatgttttca
     7021 gaaaaacttc atgattactt ttcttactaa atcttttata gggtaattcc ccctaaaccc
     7081 gatccaacaa ttccacacca ggaaccacac acttaaacct gatgctgctc catgtctcgc
     7141 accttcaaca gatccagtcc ttgctaacgc ccaaaattcc gtcatgactt tatccgaaat
     7201 agctcaaatc cacttcgctc tcttgattca gactttgaat cggttacact aaactagaca
     7261 gaatttataa agtgttctac actaaagaaa acaggagaaa caatatgtct agaaaaatac
     7321 gccgtcattt tacagatgac tttaaacaac aaatcgttga ccttcacact gcaagtatga
     7381 aacgaagtgc gctgatcaaa gaatatgatt taaccccttc tacctttgat aagtgggtga
     7441 gacaagctaa aacaatgggc tccttcaaat caattgataa tattaccgat gaacagcggg
     7501 agctgatagc tcttagaaag cgaaacaaag aacttgaaat gcagatagac atcctaaagc
     7561 aagcggcggt gattatggca caaaaaggga actaatcact gctaacaagg ataaatacag
     7621 catttcagcc atgtgtcgtt ggttgaatct cccgcgctct agctactact ataaaacctc
     7681 agaaccagta tctgaagctg atcttgaaga aaaggtgaaa caaatttttc tcgagagcca
     7741 atcgagatac ggtgccagaa agttcaagca atgtctggct acagatggga ttatcttatc
     7801 tcgtcgccgc attcgtcgaa tcatgaagcg gttaaatcta gtatctgttt accagcaggc
     7861 tagcttcaag ccatatgcta aagggaaaaa cgaagcccct attccaaatc tcttagacag
     7921 acagttccac caagaaaaac cactggaagt gattgtgaca gatttgacct atgtccgtgt
     7981 tggtcagcgt tgggcttatg tttgcttgat tattgacctc tttaatcgtg aaattattgg
     8041 cgtatctgtt ggctggcaga agactgcaga gctcgtcaaa caagccattc agagtatccc
     8101 ttatgcttta accaagtcaa tcttttccat tctgaccgtg gcaaggagtt tgacaatcaa
     8161 ttaattgatg aggtcttaga atcctttggt atcacccgtt cgctaagtca agctggctgt
     8221 ccttatgaca atgcagtagc tgagagtacc taccgttcct tcaaactgga gtttattcat
     8281 caagaaacct ttcattcact taaagaacta acccttaaaa ccaagaacta tgtccactgg
     8341 tggaatcatc atcgcattca cggtagtctc aattatcaaa cacccatcgc taagcgagtg
     8401 accgcttaac aaaaaacact ttataaaaat tgtacagaaa agtgttacct tttcaaatta
     8461 ttattcaaat cctaaacagt caccgaaacg tcttgaatgg tttatcatag acacaaaaaa
     8521 gagcagttca ttctactact gctctttcca tcttttttcg ctgcaatcgc atttgtaatt
     8581 ttagatcatt ttagacatcc ttatttcgta acttattatc taggcaagag cgtacctgaa
     8641 ggatgatctc accatacgat tcgtcacgcc tttcgtaata agccattgac agagagaaac
     8701 attaataaac atatggcaaa ggttcgttat cgtattgaac atgtttttgg ttctattgaa
     8761 aataacttga aaggaagtaa ttttaaaggc attgggttag caggagctag aacaaatgtg
     8821 accttaacta atttgctata taacatctgc cgttttgaac aaattaaacg gctatcttta
     8881 aactctaggg cgtagtgcgt ccaaaaaagg ggtaaagctg agtaatcacc caaatatgaa
     8941 ggaaccccta gagcaacatc attttttaac taaattctct taagggagaa gttgttagag
     9001 gtgccctaaa gaaagtccat atacaatgaa tttgtcatcc gatacaatct atattccttt
     9061 ttgagaattg atataggatg acactcagcg gctagactgg gactggttgg agatcaaaat
     9121 taacccattc cccttgatga cattgattag actaccgcta ccagttattt gctataaagc
     9181 taggatatca attccttttt tcatttattc ttaaaaagaa attaataaca ataagtaaat
     9241 atactatcca gataaatact aactttttat aaataagaaa taaaatgata aacacgttga
     9301 taactgacaa gtctatcgat ttttctatta ggtgtttact tttccaatct gtatatacac
     9361 tgtacaattg tacaaaaatg actgtaataa aaaatagtaa cttcatggtt atccaacagc
     9421 agtataggct aaatagccgc atactactgc acctccgaca cctccgatag cagcgcccca
     9481 aactcccaat ttggaaccat atttaatccc agttgctgca catcccattc ctgcaactac
     9541 ggcagcgcct gcagggttcc caccttcgat tttttgaagg ataccttcat caagtatttt
     9601 ataatttgac ataacttcat tctcctttaa aatccaccag ttgcaccagt tacacctgcc
     9661 catagagcca caccaaattt agctcctata tagccacagg ctggtgctag cggtgcccct
     9721 acaccagtaa cagtacagat agtagtccct agcccccacc cagcagtagc cgcaccaaca
     9781 ccttctaaca cattattttg ccaattattt tttccaccat caacactcgc aagcatttct
     9841 acgtccattt gtttaaattg ttccattgat tttgtattca taacgaatac ctccttatat
     9901 aatattttta tttttccagt tgcaaccttg acaagtctag tatagcattt cctcaaaaaa
     9961 tatttctccc atttcctgaa cagtcatcga aacgtcctaa acagtaaaat tttaccgttt
    10021 aagacgataa tagaaccatt caggagttct ttttaactcc aagatttttc tgtgctttgc
    10081 cattcaggac gtttcgatga ccatttaaga ttgagacgtt tttttcttta aatttttgtc
    10141 ataatagtct tgtcactaac aagaaaggat ttgacaaatg acctcttata aacgaacctt
    10201 tgttcctcaa attgatgcca gagactgtgg tgtagctgct ttagcttcta ttgccaagtt
    10261 ttacggttct gactattctc tagctcattt gagagaatta gccaaaacta acaaggaagg
    10321 aacaaccgca cttggtatcg ttaaagctgc ccaagaaata ggctttgaga caagagccat
    10381 ccaagctgat atgagccttt ttgatatgaa tgatgtccct taccctttca tcgttcacgt
    10441 caataaagaa ggaaagctcc aacactacta tgtagtgtat caaaccaaaa aagatcatct
    10501 tatcattggt gatcctgacc ctacagtcaa ggtgacaaag atgtccaagg agcgattttc
    10561 ttctgaatgg actggtgtag ccatttttct agctccagag cctagctaca aacctcataa
    10621 ggataaaaag aacggcctga tgagttttct ccctctgatt ttcaggcaac gtgcgcttat
    10681 cttttatatc gtcttggcta gccttttggt gacgcttatc aatattggtg gttcttacta
    10741 cctgcaaggg attttggatg aatacattcc taatcaaatg aagtcaacct tggggattat
    10801 ctccatcggc ttgattatca cctacatcct ccagcagatg atgagtttct cacgagatta
    10861 ccttttgact gtgctcagcc agcggctaag tattgatgtg attctttcct atatccgtca
    10921 tatctttgaa ctgcccatgt ccttctttgc gacgcggcgg actggtgagg ttatctctcg
    10981 ctttacagat gccaattcaa tcattgatgc cctggcatcg accattttgt cactcttcct
    11041 tgatgtctct attttgacca tcgtcggtgg tgtgcttttg gtacaaaaca ccaacctctt
    11101 cctgctctcc ttaatttcag ttcccattta catcatcatt atttttgctt ttatgaagcc
    11161 gtttgagaag atgaataacg atgttatgca gagcaattcc atggtcagct ctgccattat
    11221 cgaagacatc aacggcattg aaaccatcaa atccttgacc agcgaagaaa gccgctacca
    11281 gaagattgat agcgagttcg tagattacct ggacaaatcc ttcaaactca gtaaatactc
    11341 tatcctgcaa actaccctta aacagggagc tcagctcatt ctaaatatcg tcatcttgtg
    11401 gtttggggct caactagtca tgaacggaca catttcagtt ggacaactga tcaccttcaa
    11461 cacccttcta tcttatttta ccaatccttt agaaaatatt ataaacctcc aaaccaagct
    11521 ccagtctgcc aaggtggcta acaatcgcct gaatgaagtc tacctggttg aatctgaatt
    11581 cagtaacagt cagaccttaa cagattcaca gttcctgact ggcgatattc gctttgaaga
    11641 cctttcctat aagtacggtt tcggacgtga caccctatcg gatatcaatc tgaccatcaa
    11701 acaaggcgat aaggtcagtc tagtgggaat tagcggctca ggaaagacaa ccttggccaa
    11761 gatgattgtc aatttctttg agccttacaa gggtcgaatc accatcaaca acaatgacct
    11821 taaactaatt gataaaaaga cgcttcggca acacattaac tacctcccac aacaagctta
    11881 tatcttcagt ggttcaatct tagaaaactt gactttaggg gctaatcaac tgattagtca
    11941 ggaagatatt atcagagctt gtgagatcgc tgaaattcga caagatatcg agcagatgcc
    12001 tatgggctat caaacagaat tgtctgacgg agctggctta tcgggtggtc aaaagcaacg
    12061 gattgctttg gctagggctc tactgactaa agcccctgtt cttattcttg atgaagccac
    12121 tagcggcctt gatgtgctaa cggagaaaaa ggtcattgat aatttaatgg ccatggcaga
    12181 caagaccatt atctttgtcg cacaccgcct cagtatttct gagcgaacca accaagttat
    12241 cgttattgac caagggaagg tcattgagac tggttcacat cacgaattga tgaccaaaca
    12301 aggtttctac catcatctat ttagcaagta aggagactaa gcatgaaccc taatttgttc
    12361 aaaagtgctg aattttacca gcggcgctac cataattttg cgacacactt aattgtcccc
    12421 ttgatattat tagtcggctt tcttctaacc ttctcccttt ttgcccaaaa ggaggttacc
    12481 gtcacatcaa gaggtgaaat tactccgacg acaatcatcg cttccatcca atccaccagc
    12541 aataacccta tcacaaccaa taatctagcc aataacaagc tggttaaaaa gaatgagctc
    12601 atcatccaat acgctgaaac tatggagagt tcccaaaaac aagcccttga aacccagcta
    12661 gccactctaa atagacagaa aactggactt gaaaccctca aagaaagcct gtcacaggga
    12721 acgaacctct ttacagggga ggacgaattt ggctatatca atacttttaa caactttatc
    12781 acccagtcac aggacatcga actaggaatt tccaaaacca atgcagaggt gagtaaccag
    12841 gccgccctag caggtaatac cattgctgcg attgacacgc aaatcaatca aatctatcac
    12901 caaatagcag aatacgagga gcttcgtcaa gccattacca atagacagac cagtttatca
    12961 gctgacaatc cacaccaagc caccttaaac aatttcttag cccaatccca acaagactcc
    13021 cagacaggat taactgatca ataccttttt caaatcaacc aaagtatctc agggctagaa
    13081 tcatccatag ctagtctgaa catccaacga gctggaactg gctctgttgc aacctatgat
    13141 aacagctttg taacaaaggt tgaggtccta agaacacagt ttttacaatc ggcctctcag
    13201 cagctgacca cccttgaaac gcaaatcaca gagctagtgg cacagctaga gcaagcatcc
    13261 gtccgactag aaaacaatac cattacagct cctgaaacag gggtaatcca tctcaatagt
    13321 gagtttgaag gaaagtcttt gattccaagc ggtagtgaaa tcgctcagat ttaccccaat
    13381 atcaatcaaa ccaaagaatt cctcattact tactacgtga cttcagaaca tgtcgcctta
    13441 ctcaaagaaa aacaagacgt acgcctgagc ttagaaaaag ttggcaacca aagcatcact
    13501 gttgttggaa aaattaagtc tatcgataaa actgctacta aaactgagga ggggaatctt
    13561 ttcaaagtta ctgccttggc tcaactatcc gacaagcata gcgacgtcat ccagtacggt
    13621 ctccagggtc gagtcacaag tatcattgcc aagaagactt actttgatta ctacaaggat
    13681 aaaattttat ccaaccatga ttaaccattt aggaaagtta aatgactgtt caggatttga
    13741 atgtcaaaaa ccgccatatt ttgtgtataa taaattaaaa cttatataaa ggaggtcctt
    13801 atatgaccaa gcatcgaact tctctcactg cattcacaga gctttctcct tcagaacttc
    13861 accgcatctc tggtggagat tggtggagtg attggatgaa atattttcct aagtcaaagc
    13921 aagccataga cagcaataat aaacataaac tgggctaaca tcaaaaaatc tggaccgagg
    13981 gattaaatcc catggtccaa cttttttatt tcgatgacaa gtcaatttct agagattggc
    14041 caaacagata agatgcacta gtcgtgttaa gtgatacgtg tgggtaacgc tctagaattt
    14101 tcatgacatt atatagacca atacctctgc cctcgccttt agaactatga ccaaaggcat
    14161 aaagctctga aaggtcaact ttttcttcct tggtgttatt ttcaataata aacatttgct
    14221 tattatctac agataagaaa gcaatggtaa tctttccaaa ggttcctttg gtagcatcta
    14281 tggcattatc acatagaatc gaaacaatcg tgataaagtc cactaacttc attccttgcg
    14341 gtttaatcgc ttctggcacc tccaagctaa cggctacatg attatcatta gcctgtaaaa
    14401 atttggatgc caataaactt tttaaggcag aattatcaat attgaccaaa cgcccaatat
    14461 catatttact agctcgcaac tgtttatgcg aatcctttaa cacagattgg taaacatcct
    14521 ttatctgcac catgtcattt tcttcaattc ccaaacgtaa ggttgttaat aaatttgaat
    14581 aatcatgccg gaagccccta acctctcgat aaagctcctc aatttggtta ctatagtcct
    14641 ccaagttttt tagttgcagg gcttgttgaa aatcaaactg ctcttgtatt ttttctcgca
    14701 aatgtaaatc cagttgtttg ataattccca tgaagataac aagataagtc actagaataa
    14761 attgacgata agccattgtc ggcaatccga tgtcatactc taaataagtc aatgtttgca
    14821 ttaaaagata gtatgcaagc attacccaat tagtcatata gaggatccgt ttatcttcag
    14881 ctacaagatt gtccgttctt aacttgacaa aatcatatct taaccaacct aagaaaaata
    14941 gaacagacaa tgtagacagg agattaacga aaacaaaagt tggagtgtct tctatgatac
    15001 ctggggtctg accaaataag gggaaaataa aataaaggac catacgatag aaaagatttt
    15061 ccagaataaa aggaaataaa ccacagaaaa tcaataaggt tttagacagt ggtctcaaaa
    15121 acacaatagc caacagtaaa ccatacaaag gggtgtcaaa ataagagaag aattgacttg
    15181 aaaataactg acttaaagtc gcgaaaaggg ctgcaacgga tactctgagc agaatgacca
    15241 agaggattga acggatagaa tactttaagc ggttaacact aaaaaagaga acaatgagtg
    15301 aacccaatga aacaatggct tcaataatat agtttaaaac agacatcctt tctcctttat
    15361 ctatgcagtc tatcaataac agctaaagtt gattctagct tttgccttga aataaaacag
    15421 gtggctccat taggaaagta gatctgtttt tcatttctat ccactttaac aacattcctc
    15481 ggattgattg caaacgaacg atgacattgt acaagtcgtt tatcttgttt caaaatgtct
    15541 gacaaacttg ctgtgaactc cattcggtct gtcttggtat aaaggataac acgatgaggg
    15601 cggggagaag tctcgatgta gtacacttca ttgaatgggt attgtacttg agcatatttg
    15661 gacttaaaat agaatgaatc atccgatacg gcgctattgt ccttattgtg agtatgaagt
    15721 aaagctgctt ctattcgcga ttcaaattcg gtaactccaa gctctttgtc aatatagtcc
    15781 aaggcagata cctggtacct gaaagataag ggcataaact cggagtgtgt tgtcacaaaa
    15841 acaatactag cataagggtc aatctctcta atttgtttag cgacttgaag tccttttagt
    15901 tcgtcttcct taatctcaat atctaaaaag aagagctgat gtactccttt ttcttctatt
    15961 gcttgaagta gctgatgagg ttttcctgaa atttcaaatt ttttcggaac gatgttgtgc
    16021 ttttctaaca gcttagtaat aatcttctca attctcgctt gttgcataaa atcatcttcc
    16081 attacaaaga tattcatgct acatccctcc tttgttaatc cactgatgca gtatgtcctg
    16141 ataacgacgt cttgaaaaag taaggcaatg ttctcctttt tctccaagaa aaatacgttt
    16201 ttctcgagaa ttgataacct taatttttga acggttaact agactagacc gatggcatct
    16261 aataaaacat tccggataca attcctctat actttgtagc ttttgtaagc aatcataaat
    16321 ctctttctca gtcacaattt gaatataatg tggtttagat ggatgcgata tgatatatag
    16381 aatatctgac agcagcactt tctttgtttc atctttgact ttgataatca taaagttcat
    16441 aggtatatcc tcctatgaac actatagcat aggaacaaca tcatatttcc ttcaaatcct
    16501 aaatggttat ccaaacgtct tgaatggtaa gattttacca tttaggaaag ttagaggtct
    16561 attcaggaaa ttaagctcac taaaccaaca ataactgata taattaaatt cctaaatcat
    16621 tgagaaagaa aggatactat gattgaaatc tttccttatt ccccattaag tatttttatc
    16681 gcaatcgtca ttaaaggtta cttaatcagt catcagattt attcaaaaat caaactatct
    16741 ttctcttatt atccgtataa gtacgatagt cctactacct attttatcat aaaatctaag
    16801 tttttaacat cagagaagat gaacaattac ttaaagaatg tacgagatta ttcagaacta
    16861 gcgactatca ttattattgg caaaaatatc gattatgaag aactcttcaa aaatcattat
    16921 cgagtctttg gggtcataga tacaactgaa aacaaatcat taacttttat tcgagatcaa
    16981 attcattttt acttggacgg tctctatggt ctgaagaaga aggagagtga ctaagtgttt
    17041 ggattaaaat ctccagtctc ctaaccttat attcgtaatc atctatccat ttcgtcatgg
    17101 tgtcttgatt ttctgagatt tctttctcca cctcctccag tttaatggcc ggtgtcagat
    17161 tcatcttagc ataatcatac ctagctaacc gtctgttttc tgggtctgag ttgttgagat
    17221 tgagcaggac ttctgcgacc ttattcagat aagcaacctt atcctgcaaa tctgtaatgg
    17281 tcaaatccac ctgggcaatt tcgttgataa gttcgtcttt gacttcttgg t
//
