LOCUS       c00016_JAJQWR0..       16300 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJQWR010000024.1 Streptococcus thermophilus strain 8253 (205)
            NODE_24_length_30432_cov_427.828982, whole genome shotgun sequence.
ACCESSION   JAJQWR010000024
VERSION     JAJQWR010000024
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 02:57:07
            Original ID  :: JAJQWR010000024.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16300
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16300
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2352:6300]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2353..6300
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..16300
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16300
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03882))"
                     /tool="antismash"
     CDS             complement(274..372)
                     /locus_tag="ctg16_1"
                     /transl_table=11
                     /translation="MAQVSKIEISTILWQNSGSIYNWSAEECSSSE"
     CDS             complement(323..832)
                     /locus_tag="ctg16_2"
                     /transl_table=11
                     /translation="MFDDRLEIHSPGKLPNIVTVENIKHERFSRNPRIARTLTEFGWVR
                     EMNEGVKRIYSEMESYFLHEPKYTEPGNKVVLTLENNILSRHLRVNDKMMKKYDEFNDL
                     NDDEKAILHIMYNTGEKMTTALAARITNRGRNFASKLLKSLVNKEILEWHGTSKQDRNQ
                     YYTLAE"
     CDS             complement(1064..2329)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 94.4; E-value: 1.2e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_3"
                     /transl_table=11
                     /translation="MRKILKNKLYLKVLVSDLISNFGDTLYFIALMTYVTEIKDSNLAI
                     SIVNISETLPILFTIFFGIIADKTLNKVKMIIKTLWLRVLLYLLVAVAMNFKPSIMIVI
                     IASLVNLVADTLGQFENGLFYPISNRIVKKSDREETMAFRQTVVSVMNIINQSLGAFLI
                     TFFSFSHLAFINALTFAISLLIMLAIKNQINSYYDETISTSKISQFDFKASFSEITSNL
                     KLSINHLFSIGNMKEALLVIPILNGSLAILTPLVVVDLSKDSNLTIINSAITISLLGIS
                     TVSGGILGGTLILISKKFKSLSIGTLLKMNLTTVLLSFVAFYFQNIYLIILSSFLSSVL
                     VSALNPKMWTIIFNNIDETKLATIFGGMVTYFQIGDIVSRLLFSTLVIYLPYGYIALIY
                     IAVVFVAILYTLKSSNHIEREF"
     CDS             complement(2353..3630)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     308.6; E-value: 1e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_4"
                     /sec_met_domain="LANC_like (E-value: 7.3e-52, bitscore:
                     167.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNLLKKYEEIICKVDKLVLDSDIIDRLQRAYYTENRSYLSEYPS
                     IIIYLSYRLINCDNKEYSKLLYNRVNYYLQELLKSIKLNSTNNISLCYGFTGYVYALEF
                     LSKNCKGYDKLLDTLETILLALTKDRLREIKSSNIVKEEYFDVIQGVSSVARYLLSKEE
                     STSEQELLVKEILNYFADLIINEPTIYVEYMPNEKLRKRFPSGYINLGVAHGILGPLYV
                     LALGFEKFNITKHIPSIEKGLSYYENTFFTNTIGKIIGWNGRVSDYEENEEFRFNISWC
                     YGSLGMARVLYNIAKIIDSQKLREMAMDVFTSSIDYLNSSEILNNGICHGRSGIMLLFN
                     LMYLDTGKTQFKAISDNLFKEIINDASNSEYIFVERDIYFRGVTFDEVIDYINFGLLNG
                     VSGIVITLMAQRTGNAYPLDRMLFMQ"
     CDS             complement(3637..5745)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     490.9; E-value: 1.1e-148)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_5"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.4e-47, bitscore:
                     153.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.4e-18, bitscore:
                     57.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LGEGISQYTEICKKMSYIFNDEKQHYLKVDLVNCCDSVLPKNLKK
                     KMEDFVNFISKINLTKGYRNRELESFTEKFVEKYGEYVEIPIKELLDGNLGLGLPKQTL
                     GTHVKSSSSVEEQNFLSYLSKEVFKAVKNCKKEIDISNIPLGLLYPNSDRFVANQLELY
                     CEIKNFESQPVISVVPNTGSDMIGKSIGRFASYFPNSYISLDSQLDNVELIEFPRDSKN
                     LNVMSAQNAHSKKLLLSYDDNDNISIELDSVVVGVIKTEYRYKLYFRDLRTGSIVNFVT
                     TSMLNHKSNGVFSDLARFLLTVSLEWQDNPFSVFRIIENFDFLPYIPKIKYGDIILSEE
                     KWVLSDIDKSDLSSINQWKKDFDVPRLLYFHKADERLLVDLENDLDIQWLLKQNVDKLY
                     FTHFEKCDGKNCEFIFGFENYQNSINHYSMQEKSVRRLTNNFYKNYVKTFSSDWIYFRL
                     YGINSSILPELRERLLLFTDELLVEKLISDFHFVNYRDKDNGSLRLRFKINNDNNFEDL
                     RFRITHWIDFLLESGFCNDVSFNLYEREIERYGGDSFTTVCERMFSIDSFLTLKLFSKK
                     LLNDKDLLSVLHSTFLYVRLLGIPLKRLLELLKGNLTQNRYRKSFKKLFPNNTIVVKEF
                     KECFDCKNQFEIFNEVFREFPPIDGYFEGKNDIVYSLLHMHMNRVGIFPYRIEKRNIFI
                     LSCILQRR"
     CDS             complement(5839..6300)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_6"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.5e-19, bitscore:
                     60.6, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.3e-09,
                     bitscore: 29.1, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LFSSIGVGTFSDISYPQKIGENYTKKISVSGEWLSSICMMLENED
                     SVLLQLHIQWNQKVLELSDKYQLSNVNYWGISEINKDLFVKETGLLEFIQKLTYKSEVS
                     VLELVHTIQSKSPDLEKQKILDYIRNLITNEFLFTNLRKVAISHKDLDD"
     CDS             complement(6394..6534)
                     /locus_tag="ctg16_7"
                     /transl_table=11
                     /translation="MFKIKDNYIYRQCVNDSRLIDKLSENNLEIFFDSKVFKEMLLVAN
                     P"
     CDS             complement(6596..6700)
                     /locus_tag="ctg16_8"
                     /transl_table=11
                     /translation="MENTEFSLELDVTEVSTEQGYVFSGVTSTGCCKD"
     CDS             complement(6950..7213)
                     /locus_tag="ctg16_9"
                     /transl_table=11
                     /translation="LAHDFASWVSGDSMEPKYHNGSVTLIRETGFDYDGAVYAVVCNSQ
                     TYIKRVYLEAEGLRLKYKDIFISYDEDPRVVRIIIGNFIPLK"
     CDS             complement(7687..8079)
                     /locus_tag="ctg16_10"
                     /transl_table=11
                     /translation="MAQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDLEEYIPHADLR
                     LVINQPFAVTSTEGSYDVHVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAGLL
                     TRDARMVERKKPGLKKARKASQFSKR"
     CDS             complement(8107..8553)
                     /locus_tag="ctg16_11"
                     /transl_table=11
                     /translation="MNKTTFMAKPGQVERKWYVVDATDVPLGRLSAVVASVLRGKNKPT
                     FTPHTDTGDFVIVINAEKVKLTGKKATDKIYYTHSMYPGGLKQISAGELRSKNAVRLIE
                     KSVKGMLPHNTLGRAQGMKLKVFVGGEHTHAAQQPEVLDISGLI"
     CDS             complement(8762..9718)
                     /locus_tag="ctg16_12"
                     /transl_table=11
                     /translation="MALTYAVLGSGAMGLRFGLLLKEHLGAQVDFIDTWEEQIDTVRKQ
                     GGVYQSRDGKNRHLIPISIQTPEEYQGKPDVFIIFDKQMHLSQLLERSKHFFHENQYVF
                     TGMNGMGHIEKINRYFAPEKVLAGTCLIGTVLKDAGDVDFIGKAGAGSINLAAQSGTVD
                     DVQKQIITEFEASNLNPNLTDNFLGTLYTKVVFNSVINTICTLFEIRMGQFIDYEGAEK
                     LGRQLIDEAYNVAELAGITPLNSRDEEWETIRYVSAETSPLHYPSMYQDMNKGRQTEVD
                     YINGYIYDLGRTYNYQAKTHDFLRHLVHLAENTRKFR"
     CDS             complement(9866..10369)
                     /locus_tag="ctg16_13"
                     /transl_table=11
                     /translation="MLIKISQHFGISVDDLVKNEMQLTTNNKSKTNSRLWLIALPIFVL
                     ICVIAVGIWNKHNSQSVNFSMKDDKTYKSNDAAQTSLTVAKGYFTVPKAGKLEVKVNAT
                     TDNGNLHLTIVDNNHHHYYQIDGDDLKDSQKLYFKSGDYCIRITADAYTEKVVSLDYNI
                     KVNS"
     CDS             complement(10670..11530)
                     /locus_tag="ctg16_14"
                     /transl_table=11
                     /translation="MTFKILTDSTADLDEKWAQENDVELIGLTITLDDITYETVGPNRL
                     TSDRLLEAMQEGGQPTTSQVNVGQFEEVFRRHAQNGDDLLYLAFSSVLSGTYQSAVMAR
                     DMILDEHPEAVIEIVDTLAAAGGEGYLSILAAEARDQGKSLAKTKAMIEDILPRLRTYF
                     LVDDLYHLMRGGRLSKSSAIIGSLINVKPLLWLDDSGKLVPLAKIRGRKKAIKELVLYA
                     TQDIGHSTAVIAYANDLEAAENLKEQLLTVNGIEQVLIMPLGPVISTHVGPGTLAVFTI
                     GEKAR"
     CDS             complement(11539..12054)
                     /locus_tag="ctg16_15"
                     /transl_table=11
                     /translation="MKKRILLVDGYNMIAFWKETRQLFKTNQLDEARETLLRKLNHYAN
                     FEHIDIICVFDAQFVPGNRQRYDQYRVSVIFTEEDETADSYIERSAAEMNTIQNLVEVA
                     TSDLNEQWGIFSQGALRVSARELEERVNTVKSDLDKMSAHIDLTTPKLRPWDETQLGKL
                     QNLLNEIK"
     CDS             complement(12057..12800)
                     /locus_tag="ctg16_16"
                     /transl_table=11
                     /translation="MKTTKESILDIVYGVHAVTESLEANTGNKLYIQDDLRGKNVDAIK
                     ALAAEKKVSISWTPKKTLSDMTGGAVHQGFVLRVSEFAYSDLSVIMDKAEQEENPLILI
                     LDGLNDPHNFGSILRTADATQVTGVIIPKHRAVGVTPVVAKTSTGAVEHIPIARVTNLS
                     QTLDKLKEAGFWVFGTDMDGTASHKWNTAGKLALIIGNEGKGISANIKKQVDEMITIPM
                     GGHVQSLNASVAAAVLMYEVYRNRL"
     CDS             complement(12848..13090)
                     /locus_tag="ctg16_17"
                     /transl_table=11
                     /translation="LIYSSEVTFTDELISEIFGNSSTSVGSIDILQAAGKTVTQAARKI
                     AESIADLDTIGKQTLAAARVVLFLLVFYLAEITFI"
     CDS             complement(13161..13349)
                     /locus_tag="ctg16_18"
                     /transl_table=11
                     /translation="MVFSSSETDEALLEVHSQVDIIETSVSMAKPHSEEARVQALGEDR
                     SVAGSERGDSSPISEVA"
     CDS             complement(13863..14264)
                     /locus_tag="ctg16_19"
                     /transl_table=11
                     /translation="VTKHIDVNLINGIALAFEGDAVYSLYIRRHLIFQGQTKPNQLHRL
                     ATCYVSAKAQASLIEKMLERELLTEKELDIYKRGRNAKSHTKAKNTDVITYKMSTGFEA
                     VMGYLHMTEDIDRLEELVAWCIDEVEKEI"
     CDS             complement(14257..15600)
                     /locus_tag="ctg16_20"
                     /transl_table=11
                     /translation="VIKIYDTMTRSLRDFVPLTENTVNMYVCGPTVYNYIHIGNARSTV
                     AFDTIRRYFEYRGYTVNYISNFTDVDDKIIKAANEVGISTKELSDKFITAFMEDTAQLG
                     IKPATQNPRVINYMDEIIAFVSILIDKGFAYVSEGDVYFRVTKSNNYAKLANKTLEDLE
                     IGASGRTDAETDRKEDPLDFALWKAAKEGEISWESPWGPGRPGWHIECSVMATEILGDT
                     IDIHGGGADLEFPHHTNEIAQSEAKTGKTFANYWMHNGFVNVDNEKMSKSLGNFVTVHD
                     MLKTVDGQVLRFFLATQQYRKPINFTEKAIHDAEVNLKYLKNTHSLPLTEEVSQAELQA
                     YLDAFQAAMDDDFNTANGVTVLFDMAKWINSGNYDETVKDAFEKILQVFGIVFEEETLD
                     EDIEKLIEERQAARANKDFATADRIRDELAAQGIKLLDTKEGVRWTRD"
     CDS             complement(15628..15729)
                     /locus_tag="ctg16_21"
                     /transl_table=11
                     /translation="MFLLAQGLLVAAMGIIILVILLCLYLNHFRDKK"
ORIGIN
        1 aaatagcacc ccaaaagtta gattttttct gtctaacttt tggggtgcgg ttcataactc
       61 ttgaatgtct tgaaacattg atataatcgt attgattaac gttttgagaa ttgtgaagct
      121 ttacgagctt tcttaagacc tggttttaaa ccaatgaatt tcaatataac ttaataggta
      181 gaaactacag gcaactaggc cttttctttt gtccagaatt tcaaaaagtt tgagattttt
      241 tgaggaaaac aggggaaatt cacttactgc gttttactcc gaactactgc actcttctgc
      301 actccagtta taaatagatc cgctattctg ccaaagtata gtactgattt ctatcttgct
      361 tacttgtgcc atgccattcc aggatctctt tatttacaag actctttaat aatttacttg
      421 caaaatttct acccctattt gttattctag cggccaaagc agtagtcatt ttttctccgg
      481 tattatacat gatatgtaaa attgctttct catcatcatt taaatcattg aattcgtcat
      541 attttttcat catcttatca ttaactctca aatgtcggct caaaatatta ttttcaagag
      601 ttaaaacaac tttatttcct ggctctgtgt atttaggttc atgcaagaaa taagattcca
      661 tctcagaata gattcgcttc actccctcat tcatttctcg tacccatcca aattctgtta
      721 aagttctagc aatacgagga ttacgagaaa aacgttcgtg cttaatattt tcaaccgtta
      781 cgatattagg aagcttacct ggactatgaa tttctaatcg atcatcaaac atcataattc
      841 ggatataatc gccaaaaatg gagcaatttc tatgagttac cgcatttaca tcccttcaaa
      901 ccaagcaaat tctggatact ctggtaatgt tttaaattgc ccatcatcca aatattgaaa
      961 ttctctaagc tgagtacgaa caaaatctcg aactttagta ctcaatcttg aaaataggtt
     1021 ttcaatagta gaaaatttgg aaaactataa tcatttaact aatttaaaat tccctttcta
     1081 tgtgatttga actttttaat gtatataaaa ttgccacaaa aacaactgct atatatatta
     1141 atgcgatata accatacggt aagtaaatca ctaaggtaga aaacaataac cttgacacaa
     1201 tatctcctat ttggaaatat gttaccattc ctccaaatat tgtagccaac ttcgtctcat
     1261 caatattatt aaatatgata gtccacattt taggatttaa tgcactaact aatacactcg
     1321 aaagaaatga tgataatata attaaataaa tattttggaa gtaaaaagca acgaatgata
     1381 gtaaaacagt cgttaaattc atttttagca aagtgcctat ggaaaggctt ttaaattttt
     1441 tactaattag aattaaagtg cccccaagta ttcctcctga aacagtgcta attcctaaaa
     1501 gcgagatcgt aatcgctgaa ttaataattg tcaaattaga atctttagaa agatcaacaa
     1561 caactaatgg cgtgagaatt gccaaactcc cattaagaat tggtataaca agtaaagctt
     1621 ccttcatgtt gccgatacta aatagatggt taatcgagag ctttaaattt gaagtaatct
     1681 cagaaaatga agctttaaag tcaaattgtg atatcttact tgtcgagatc gtctcgtcat
     1741 aatagctatt aatttgattt ttgattgcta acataattaa cagactaata gcaaaagtta
     1801 gagcatttat aaatgctaag tgagaaaaac taaaaaaagt aattaaaaac gcacccaatg
     1861 attgatttat aatattcatc acagaaacaa cagtttgcct aaacgccata gtttcttctc
     1921 tatctgactt tttcactatt cgattagaaa ttggataaaa aagaccattt tcaaattgtc
     1981 ccaatgtatc tgcaacaaga ttaacgagac tagcaattat gactatcata atagaaggtt
     2041 taaaattcat agccacagca accaataaat atagcagtac ccgtagccat aacgttttaa
     2101 taatcatttt cactttatta agcgttttat ctgcaatgat accaaaaaat attgtaaata
     2161 aaataggtag agtttccgat atattgacga ttgaaatagc taaattacta tccttaatct
     2221 ccgtaacata ggtcatgaga gctataaagt ataatgtatc tccaaaattt gatatcaaat
     2281 ccgaaaccag aacttttaga tatagtttgt tttttaagat ttttctcata cttctccttt
     2341 aacttaaaaa cttcactgca taaacagcat tctatccaat gggtaggcat ttccagtcct
     2401 ttgtgccatt agagttataa ctatccctga aacaccattt agcaatccaa agttaatata
     2461 atcaataacc tcatcaaagg ttacgcctct aaaatatatg tcacgctcca caaatatata
     2521 ctcagaatta gaagcatcat ttataatttc tttaaataaa ttatcagaaa ttgctttaaa
     2581 ttgtgtcttt cctgtatcta aatacatcaa attgaacaaa agcattattc cagaccgtcc
     2641 atgacaaatt ccattattta aaatctcact gctattaagg taatcaatag atgaagtaaa
     2701 tacatccatc gccatttctc gtaatttctg actatcaatg attttcgcta tattatatag
     2761 tactcttgcc attccaagac tgccatagca ccaacttata ttaaatctaa attcctcatt
     2821 ctcctcataa tcactgactc taccattcca accaattatt tttccaattg tattggtaaa
     2881 aaaggtgttc tcatagtaac tcaagccctt ttctattgaa ggtatgtgtt ttgttatatt
     2941 aaatttttca aatcctaacg ccaacacgta tagtggtccc aatataccgt gagctacacc
     3001 tagattaata tagccactag gaaatctttt ccttaatttt tcatttggca tatattccac
     3061 ataaatagtt ggctcgttaa ttattaggtc tgcaaagtaa tttaatattt cttttactaa
     3121 taactcttgt tcagaagttg attcctcttt gctaagcaaa tatctagcta cactagagac
     3181 accttgaatt acatcaaagt attcttcttt aacaatatta gagcttttta tttcacgtag
     3241 cctatctttt gttaaagcta ataaaattgt ctcaagtgta tctagtaatt tatcatatcc
     3301 tttacaattt ttagataaaa attccaaggc atatacatag cccgtaaatc catagcaaag
     3361 tgaaatatta ttagtgctat tcaatttaat agactttagc aattcttgta gataataatt
     3421 tactctatta tagagaagct tagaatactc cttattatca caatttatca acctatagga
     3481 taaatatata attatacttg gatattctga taagtaactt ctattttctg tataatatgc
     3541 tctctgcaat ctgtcaataa tatcactatc caacacgagt ttatctactt tacagataat
     3601 ttcttcatac tttttaagta aattcctcat aattattcaa cgcctctgca atatacatga
     3661 taaaataaag atattccttt tctctattct atatggaaat atgcctactc tattcatatg
     3721 catatgaagt aaactataaa ctatatcatt tttaccttca aaatatccat caataggcgg
     3781 gaactctcta aatacttcat taaaaatttc aaactgattt ttgcaatcaa aacattcttt
     3841 gaattccttt actactattg tgttatttgg gaataacttt ttaaaacttt tacgatatct
     3901 attttgagtc aaattcccct tcagcaactc aagtaatcgc tttaatggga tccctaataa
     3961 tcgaacatat aaaaatgtcg aatgcaaaac agataataaa tctttatcat ttaataattt
     4021 cttcgaaaat aactttaagg taagaaaact gtcaatagaa aacatcctct cacaaactgt
     4081 tgtaaagcta tctccaccat atctctcaat ttccctctcg tataaattaa aactaacatc
     4141 attacaaaaa ccactttcaa gtaggaaatc tatccaatgt gtaattcgaa atcttaaatc
     4201 ttcaaaatta ttatcattat ttattttaaa acgtaatcga agcgacccat tatccttatc
     4261 tctataattt acaaaatgaa aatcactaat tagcttttca accaatagtt catctgtaaa
     4321 taaaagaagc ctctctctta gttcaggtag aattgaagaa ttaattccat ataacctaaa
     4381 atagatccaa tcactcgaaa atgttttaac atagttcttg taaaagttat ttgtcaatct
     4441 tctaacagat ttttcctgca tagaataatg atttatacta ttttgataat tttcaaatcc
     4501 aaatataaac tcacaatttt taccatcaca tttttcaaaa tgcgtaaaat acagtttatc
     4561 aacattttgt tttaaaagcc actggatatc taaatcattc tctaaatcaa ccaatagacg
     4621 ctcatcagct ttatgaaaat acagtagtct aggtacatca aaatcttttt tccattgatt
     4681 aatagaggat aaatcacttt tatctatatc tgataaaacc cacttctctt cacttaaaat
     4741 tatatctcca tatttaattt taggaatata gggaagaaaa tcaaaatttt caattatcct
     4801 aaacactgaa aacggattat cttgccattc taaagaaacc gttagtaaaa atctcgctaa
     4861 atcgctaaat actccatttg atttatgatt tagcattgat gttgttacaa aattaacaat
     4921 tgagcctgtt cgtaaatccc taaaatataa tttatatcga tattctgttt ttataacccc
     4981 caccaccaca gaatctaatt caatcgatat gttatcattg tcatcataag ataataataa
     5041 ctttttagaa tgagcattct gtgccgacat aacatttaaa ttcttactat ctcttggaaa
     5101 ttctattaat tctacattat ccaactgtga atctaacgag atataagaat taggaaaata
     5161 ggaggcaaac cttccaatag acttccctat catgtcactc cctgtatttg ggacaactga
     5221 tataacaggt tgagattcaa aattcttaat ttcacaatat aactctaact gatttgcaac
     5281 aaatctatcc gaatttgggt ataacaatcc taaaggtata tttgatatat ctatctcttt
     5341 tttacaattt ttaacagctt tgaagacttc tttactcaga taagacaaaa aattttgctc
     5401 ttctacacta cttgatgact ttacatgagt tcccaaagtt tgttttggta aacccagtcc
     5461 taaattacca tctaataatt ctttaattgg aatttcgacg tattccccat atttttcaac
     5521 aaatttttct gtaaatgatt ctaattctct gtttcgataa cctttagtca gattaatttt
     5581 tgaaataaaa ttaacaaaat cctccatttt ctttttcaaa tttttgggca acaccgaatc
     5641 gcaacaattt actaaatcaa ccttcaggta atgctgcttt tcatcattaa aaatatacga
     5701 cattttttta caaatttcag tatattgaga aatgccttct cccaactcta attttgcata
     5761 ctgctcaata ctatttttta tttgtaataa atcctcggtt aattttcttt ggttatcaat
     5821 atcctttaaa atgttggttt aatcatctaa atctttatgg cttattgcaa cttttcgcaa
     5881 gtttgtaaac aaaaattcat tagtaatcaa attacgtata taatctaaaa ttttctgctt
     5941 ctctaaatca ggagatttac tttgaattgt gtgtaccagt tctaacacac tgacttccga
     6001 tttatacgtt aatttttgta tgaattctaa aagtccagtt tccttgacaa ataaatcctt
     6061 atttatctca gagattcccc agtaattgac attacttaat tgatacttat ctgataattc
     6121 aagtactttt tggttccact gtatatgtag ttgtaataag acagaatctt cattttctaa
     6181 catcatacaa atcgaactta gccactctcc actaaccgag atttttttcg tataattttc
     6241 tccaatcttt tgaggatatg agatatcaga aaaagttcct acaccaattg aactaaacaa
     6301 tccaaacggc gttgctcttg taattgatct ttttacatag tttctaaagg tggaattttt
     6361 atatattttt tctttagtta aattattgaa aaattaaggg ttcgccacta gcaacatttc
     6421 tttaaaaact ttgctatcaa aaaatatttc aagattattt tcactaagtt tgtctataag
     6481 tcttgaatca ttaacacatt gcctataaat gtaattatct tttatcttaa acataattct
     6541 cttctaaaaa aaggcaagta ctacttatac ctgccttatt agatcaatta taaaactagt
     6601 ctttacaaca acctgtagat gttacaccac taaaaacata accttgctca gttgaaacct
     6661 cagttacatc aagttccaat gaaaattctg tattttccat gataactctc ccccttcttt
     6721 aagttgtgtt tataatacta aaagcaaatt tatttgtcaa taatttttag aaaattcatt
     6781 ctttttgttt cggagtatta taaaataaaa tccgtctgta ctatcaaaca agctctgtta
     6841 tcagaagata tttcataaga aatccttaac agatgtcatt acatttttga aaactataat
     6901 cattatcaaa aaagcaaaca agttgacaat tcaggactag aaaaacgtat tatttgagag
     6961 gtataaaatt tccaataata attctcacta ctcgtggatc ctcgtcataa gaaataaaga
     7021 tatccttata ctttagacgt agaccctctg cttcaagata tactcgctta atgtatgttt
     7081 gactattaca taccacagca tatacggcac catcatagtc aaaacctgtt tcacgaatga
     7141 gagtaactga accattgtga tactttggct ccatagaatc tccagacacc catgaggcaa
     7201 agtcatgcgc caactcctcc gtaaagtaaa ccgtatcata ataaggaatt aaaactattt
     7261 ggtttacgcc agactcaaaa gcagtttgtg tttacctata atgaccgatc caataatatc
     7321 aaccttccac ttcatacaga ttacctcaac tatagaatga attctgtcat acgtaggcat
     7381 ccagaactat cccctgcttc accacataag ttaagacaca caggtgccac tcttgcaaga
     7441 aaatctggcg ttcccctaga gattatttcc gaggcattaa ctcatagtga taaacaaatt
     7501 acaaagacct atgttaacac aaaaatatag taaatcaaac tgctggagat attgcatata
     7561 gaagcttaaa aaaataatag ggtgaacatg gggtgaattt tggggtgaac tttataaatt
     7621 tcaacaaaaa aagacaccca agagataact cttgaatgtc ttgaaacgtt gatataatcg
     7681 tattgattaa cgttttgaga attgtgaagc tttacgagct ttcttaagac ctggtttctt
     7741 acgttcaacc atacgtgcat cacgagtaag aagtccagcg cgtttcaatg aatcgcggaa
     7801 gtctgggtct acttgaagaa gtgcacgagc gataccgtga cggatcgcac ctgattgacc
     7861 ggcgtatcca ccacctacaa cgttaacgtg tacgtcgtac gaaccttcag ttgaagtaac
     7921 tgcgaaaggt tggttgataa cgagacgaag gtctgcgtgt gggatgtatt cttctagatc
     7981 ttttttgtta acagtgattt taccagtacc tggaaccaaa cgtacgcgtg caacagcgtt
     8041 tttacggcgt cctgtacctg catattgtgc ttgtgccatt atattagtgc tcctttcctc
     8101 ttagaattag ataagtcctg agatatcaag tacttctggt tgttgtgcag cgtgagtgtg
     8161 ctcaccgcca acgaagactt tcaatttcat accttgtgcg cgtccaagag tattgtgtgg
     8221 aagcatacct ttaactgatt tttcgatcaa acgaacagcg tttttagaac gaagttcacc
     8281 tgctgagatt tgtttcaaac cacctgggta cattgagtga gtgtagtaga tcttatcagt
     8341 tgctttttta ccagtcaatt taactttttc agcattgata acgattacga aatcacctgt
     8401 atcagtgtgt ggtgtgaaag ttggtttgtt ttttccgcga agtacgctag caactactgc
     8461 agaaagacgc ccaagtggca catcagttgc gtcaacgaca taccatttac gttcaacttg
     8521 gcctggttta gccataaatg ttgttttgtt catgatttct cctatatata gttcgatttt
     8581 tgtttacgag tgatgggtgt cccttcccat cgaaaagtat atttggaagg ttccggggcc
     8641 tttcaaatgg ggtaaacaat accgtttaac ataatatcaa aaaaacaagt ccaaggcaac
     8701 acttacctac catcttttct aagtttttta gcgatttttt cttctttttc atagaaaatg
     8761 cttagcggaa tttacgggta ttttctgcta agtgaactaa gtggcgtaaa aagtcatgcg
     8821 tttttgcttg gtaattataa gtcctgccta aatcatagat ataaccattg atataatcaa
     8881 cttctgtctg acgtcctttg ttcatatctt ggtacattga cggataatgc agagggcttg
     8941 tttccgcgct aacataccga atagtctccc attcttcatc acgactattc agaggagtaa
     9001 tgcccgctaa ttcggcaacg ttataagctt catcaattaa ttgacgtcct agtttttcgg
     9061 caccttcata atcaatgaat tgtcccatac gaatttcaaa aagggtgcaa atggtattga
     9121 tgacagaatt gaacacaact tttgtgtaaa gtgttcctaa aaaattatca gtcagatttg
     9181 gattgaggtt tgaggcttca aattcagtta ttatctgctt ttgaacatca tcaaccgtcc
     9241 ctgattgagc ggcaagatta atagaaccag cacctgcttt tccaataaaa tcaacatctc
     9301 ctgcgtcttt caagaccgtt ccaatcagac aagttcctgc taaaactttt tcaggcgcaa
     9361 aatagcgatt gattttctcg atatgtccca tgccattcat tcctgtgaaa acatattgat
     9421 tttcgtggaa gaaatgctta cttcgttcga gcaactgtga caaatgcatt tgtttatcaa
     9481 aaatgataaa aacatctggt ttcccttggt attcttctgg tgtctgaatg ctaattggaa
     9541 tcagatgacg atttttacca tcacgtgatt gataaacacc accttgtttt ctaaccgtgt
     9601 cgatttgctc ttcccacgta tcaataaaat ccacttgagc accgaggtgt tcttttaata
     9661 gcagcccaaa acgtagtccc attgcaccac ttccaagtac agcataagtc aaagccatgt
     9721 cttttcctcc tttgatttca aaaattatat cacttcatca gtcgaatatg gaggaaatca
     9781 ggtataaaat tttcttatgg ctagctataa ataaagccta taaataaagc aatgaaagat
     9841 ttcatgtgct ttttcaaaca agtcactaac tattaacttt aatattgtaa tccaaactaa
     9901 caactttttc tgtataagca tcggctgtaa tgcgaataca atagtctcca cttttaaaat
     9961 agagcttttg tgaatctttt aagtcatcac catctatttg ataatagtga tgatgattat
    10021 tatctacgat agttaggtga aggttgccat tatctgtcgt cgcattaacc ttgacctcta
    10081 atttaccagc ttttggaact gtaaaatatc ctttagccac tgtcagagag gtttgtgccg
    10141 catcattact tttataagtt ttatcatctt tcatggaaaa attaactgat tggctattgt
    10201 gtttattcca aataccaaca gctattacac aaatgaggac aaaaattggt agagcaatca
    10261 accataagcg agagttcgtc ttggatttgt tgttagtcgt caattgcatt tcatttttga
    10321 ctaagtcatc aactgagatt ccaaagtgtt gactaatttt aatgagcatt tcaacatcgg
    10381 gataactttt cccattttct caactagaaa ccgtttgtct agatacatgg aataaattag
    10441 caaacccatc ttgactaaga ttattctttt ttcttaattc attgatattc attataaagc
    10501 tctcctttcg ctactgacgt aacgagtaca ttatctcctt tttcgttttg aaacactatc
    10561 caatatcctt gacatattag ctaaggtgcc tttacatcgt gtcaaattca cttgacagtc
    10621 ccattttaca ataaaagagc agtattttac tactcttttt actttaactt tatctagctt
    10681 tctcaccaat cgtaaagacg gctaatgtcc ctggtccgac gtgggtagaa ataactggac
    10741 ctagtggcat aataagaact tgctcaatgc cgttaactgt taacaattgt tcttttagat
    10801 tctcagcagc ttctaaatca ttagcataag cgataaccgc tgtgctatgt ccaatatcct
    10861 gagtagcata caacaccaat tctttaatgg cttttttacg tccacggatt ttagccaaag
    10921 gaaccaactt acccgaatcg tctagccaaa gaaggggctt gacattaatc aaactaccaa
    10981 taattgctga gctcttagaa agacggcccc cacgcataag atgatagaga tcatcaacta
    11041 agaaataagt tcgtaaacgt ggcagaatgt cctcaatcat ggctttcgtt ttggctaaac
    11101 tcttaccttg gtcacgagct tctgccgcca agatagagag ataaccttct ccacctgctg
    11161 ccgccagggt atctacaatc tcaatgacag cttctggatg ctcatccaaa atcatgtcac
    11221 gcgccataac ggcactttga taagtacctg aaagcactga tgagaaggcc agataaagga
    11281 gatcatcacc attttgagcg tgacgacgaa aaacctcttc aaattgacca acattcacct
    11341 gacttgtggt cggttgacct ccttcttgca tagcttccaa cagacggtca ctcgttaatc
    11401 gattggggcc aactgtctca taagtaatat catcgagcgt aatggttaga ccaataagtt
    11461 caacatcatt ctcctgagcc catttttcat ctagatctgc tgttgaatct gtcaaaattt
    11521 taaatgtcat atatccctct attttatttc atttaaaagg ttctgtaatt ttcctaattg
    11581 tgtttcgtcc catggacgta acttgggggt tgttaagtca atatgtgctg acatcttgtc
    11641 taaatccgac ttaacggtat taacacgctc ctccaactca cgtgctgaaa cacgtaaagc
    11701 tccttgagaa aagatgcccc actgttcatt taagtcgcta gttgctactt caactagatt
    11761 ttgaatagta ttcatctcgg ctgctgagcg ctcaatatag ctatcagctg tctcgtcttc
    11821 ctcagtaaaa ataacactga cacggtactg atcatagcgc tgacgattcc ctggaacaaa
    11881 ctgggcatca aacacacaga tgatatcaat atgctcaaag ttggcataat gattaagctt
    11941 acgaagcagt gtttcacgag cttcgtcaag ctgattggtc ttaaagagtt gacgggtttc
    12001 tttccaaaag gcaatcatat tataaccatc aaccagaagt attctttttt tcatagttac
    12061 aatcgatttc gataaacttc atacataaga accgcagctg ccacactggc atttaggctc
    12121 tgcacatggc cacccatagg aatagtaatc atctcatcaa cttgtttctt gatgttagca
    12181 gagatcccct taccttcatt accaatgata agagcaagct tgccagctgt gttccattta
    12241 tgagatgctg taccatccat atctgtacca aatacccaaa aacctgcttc ttttagctta
    12301 tcaagggttt ggctaagatt agtcactctt gcaatcggaa tatgctccac cgcccctgtt
    12361 gatgtcttgg caacgacagg tgttacccct acagcacgat gcttgggaat aataactcct
    12421 gtcacctgag tagcatcagc cgttcgtagg atagaaccaa agttatgagg atcattaagt
    12481 ccatctaaaa tgagaatcag agggttctcc tcttgctcag ccttatccat aataactgag
    12541 agatcagagt aagcgaactc tgacacacga aggacgaaac cttgatgaac agccccacct
    12601 gtcatatcag acaaggtttt ctttggtgtc caagagatgg aaaccttctt ttcagctgcc
    12661 aaggccttaa tagcatccac atttttccct cgaagatcgt cttgaatata gagtttgttt
    12721 ccagtattag cttctagact ctccgttaca gcatgcacac cataaacaat atctaggatt
    12781 gattctttag ttgttttcat atgcccattc tatcataaaa aaagcactct tacgagggca
    12841 aagcgtatta aataaatgta atttccgcta ggtaaaaaac tagaagaaat aaaacaaccc
    12901 ttgcagcagc caaagtctgc ttaccaattg tatctagatc tgcaattgat tccgcaatct
    12961 ttctcgcagc ctgggtaacg gttttacctg ctgcttgtaa gatgtcaatt gagcctacac
    13021 ttgttgaact gtttccgaaa atctctgaga taagttcgtc tgtaaaggtt acttctgacg
    13081 aatagatcaa attctcaatc tatactttta tccaactgac ttatttctgc agttgtctat
    13141 acaagagatc tatcagtttc ttaagccact tcagatattg ggcttgaatc tcctcgctca
    13201 gatccagcta ctgatcggtc ctcaccaaga gcctggacac gagcctcttc tgaatgaggt
    13261 ttagccatag aaacactcgt ttctataata tcaacttgag aatgcacctc aagaagcgcc
    13321 tcatctgtct cacttgaaga gaaaaccatc agtgacgttg aggttaccac tgagcttact
    13381 tgactgagtg gttctgcctg ggcttcaact gaagaaaaat caacttacgg agctgatgcc
    13441 tcactattaa cataatctat tttagcttca tcagatttca cctgaacttc gtctgcttta
    13501 cctgtttgca acataaaact agacaaaatc aaaacaacaa aagttgtata gaaaactttt
    13561 tccttagcta tttcattcac ctcctcattt ttgatataga ctcatttact aacattatag
    13621 acttctttaa ctttctgtta aaagagtttt attaaaaaac attatagtat cgagattaca
    13681 cgtgtcagac actccttaat ttcctcattt taaagcctct aaatatcagt tttatcttat
    13741 tttttattgt taaaacactg aattactttg attctcaaac aatattgatt tttagacgtc
    13801 gtttattttt cacaatctag atgaatttta aacaacaaaa aatcctactc tcagcagaat
    13861 ttttagattt ctttttcaac ttcatcaatg caccaagcaa ccaactcttc tagacggtcg
    13921 atatcctcgg tcatatgaag ataacccatg actgcctcga agcctgttga cattttatag
    13981 gtaataacat ccgtattttt agctttggta tgactcttag cattacgacc tcgtttgtag
    14041 atgtccagct ctttttcagt caaaagctct cgctctagca ttttttcaat gaggctagct
    14101 tgagccttgg cggaaacata gcatgtagct agacgatgca attgatttgg cttagtctgt
    14161 ccttgaaaaa tcaggtgacg gcgaatgtat aaggaataaa cagcatctcc ctcaaaggcg
    14221 agtgcaatac cattaataag attgacatca atgtgtttag tcacgtgtcc acctcacgcc
    14281 ctccttggta tcaagaagtt tgataccttg agcagctaac tcatcacgaa tacgatctgc
    14341 tgtcgcaaag tccttgttgg cacgagctgc ttgacgctct tcaatgagtt tttcgatatc
    14401 ttcatcaaga gtttcttctt cgaaaacaat accgaagact tgtagaattt tttcaaaagc
    14461 atctttaaca gtttcatcat agttgcctga attaatccat ttagccatat caaacagaac
    14521 agtcacacca tttgccgtat taaagtcatc atccatagcc gcctggaaag catcaagata
    14581 agcttgcaat tcggcttggc ttacctcttc tgttagtggt agactgtgcg tatttttcaa
    14641 atacttgaga ttgacttcag catcatggat agctttctcg gtaaagttaa ttggtttacg
    14701 atactgttgt gtcgctagga agaagcgaag cacttgccca tcaaccgtct taagcatatc
    14761 atgaacagtc acaaagttac ccaaggattt tgacattttc tcattgtcca cattgacaaa
    14821 accgttatgc atccagtaat tagcaaaggt cttaccagtc ttggcttctg attgtgcgat
    14881 ttcattagta tggtgtggga actcaaggtc cgcacctcca ccatgtatat cgatagtatc
    14941 cccaaggatt tcagtcgcca taacagaaca ttcgatgtgc cagcctggac gtccaggtcc
    15001 ccaaggactt tcccaagaaa tctctccttc tttggcagct ttccaaaggg caaaatccag
    15061 aggatcttcc ttacgatctg tctcagcatc cgtacgtccg ctagcaccaa tttcaagatc
    15121 ttccaaggtc ttgttggcta atttagcata attgtttgac ttagttactc ggaagtatac
    15181 atcaccttca gaaacataag caaaaccttt atcaatcaag attgatacaa atgcaatgat
    15241 ttcatccatg tagttaataa cacgaggatt ttgtgttgct ggtttgattc caagttgtgc
    15301 ggtatcttcc ataaaggctg tgataaactt gtctgataat tctttggtcg aaataccaac
    15361 ttcattggcc gccttgataa tcttatcatc tacatctgta aagttagaaa tgtagttaac
    15421 agtgtaacca cgatactcaa aataacgacg aatggtatca aaagctactg ttgaacgggc
    15481 atttccgata tgaatataat tgtagacggt tggtccgcaa acatacatat tgacagtgtt
    15541 ctctgtcaaa ggtacgaaat cacggagcga acgtgtcatt gtatcataaa tttttatcac
    15601 tagagattcc tttcaattaa ttggagacta ttttttatcc ctaaaatggt ttaagtataa
    15661 acataagagt ataacgagaa tgataatccc catggccgca actagcagac cttgagccaa
    15721 aagaaacata gcagaaacaa agctcccaac tatataaaat aaaagaccaa aaaaggatta
    15781 cttttgaaca attttttcac aactcaagtc tcacttgtga cgttatttgt agacaatacc
    15841 agcccacaaa aaagagatac aaaaccataa agcagccctg ctataatccc ctctatgtaa
    15901 agcaatgtaa acaagagcga gtggacctac aatggtcagt cgagtcacct ttgaactaaa
    15961 gagtctcatc tttttctttc cttatagacg tgatgagtga aagctagctg cttttagaag
    16021 atcttctagc ttttcgctat agtattcacg accttcctca atgtcatgaa tcacttcttc
    16081 atccttttta ccgtgaacac gtacgacctt agcagggaca ccaactaccg taacatcttc
    16141 tgggacatcg gcaacaacca cagctcctgc acctaccttg gcattttttc caatctcaat
    16201 agggccaata atctgagcat gggctgaaac caatgcaccc tcacgaacgg ttgggtgacg
    16261 ttttccgaca tctttaccag taccacctaa agtaacaccg
//
