LOCUS       c00015_JAJTJS0..       12866 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJTJS010000023.1 Lacticaseibacillus rhamnosus strain ICIS-627
            NODE_23_length_47998_cov_260.710409, whole genome shotgun sequence.
ACCESSION   JAJTJS010000023
VERSION     JAJTJS010000023
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 11:44:06
            Original ID  :: JAJTJS010000023.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12866
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12866
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[808:2866]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Flavoprotein,
                     Semialdhyde_dh]) and gallic_acid)"
                     /neighbourhood="10000"
                     /product="gallic_acid_met"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      809..2866
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Flavoprotein,
                     Semialdhyde_dh]) and gallic_acid)"
                     /neighbourhood="10000"
                     /product="gallic_acid_met"
                     /protocluster_number="1"
     cand_cluster    1..12866
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [Flavoprotein,
                     Semialdhyde_dh]) and gallic_acid)"
                     /kind="single"
                     /product="gallic_acid_met"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12866
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="gallic_acid_met"
                     /region_number="1"
                     /rules="(minimum(1, [Flavoprotein, Semialdhyde_dh]) and
                     gallic_acid)"
                     /tool="gutsmash"
     CDS             3..89
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="YVTWFNHDRISLNKNGLTPIEYRNQAAV"
     CDS             809..2284
                     /gene_functions="biosynthetic (rule-based-clusters)
                     gallic_acid_met: gallic_acid"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_2"
                     /sec_met_domain="gallic_acid (E-value: 6.5e-229, bitscore:
                     751.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTASPWDLRKVLDELKQDPQQYHETDVQVDPDAELAGVYRYIGAG
                     GTVERPTQEGPARMFNNVVGFPTTRVLIGLMASRKRVGKMFHQDYHTLGRFLNKAVLNP
                     IQPVTVEESAAPAHEVVAKASDPDFDIRKLVAAPTNTPQDAGPYITCGVVLGSNMAKTM
                     TDVTIHRMVLEDKDTLGIYIMPGGRHIGHFAEEYEKANKPMPVTINIGLDPAITIGATF
                     EPPTTPLGYDELGVAGAIRQEPVQLVQAVTVDEKAIARSEFTLEGYIMPNTRIQEDINT
                     HTGKAMPEFPGYDGDANPALQVIKVTAVTHRRDHPIMQSVIGPSEEHVSMAGIPTEASI
                     LQLVDRAIPGKVKNVYNPPAGGGKLMTIMQIHKDNPADEGIQRQAALLAFSAFKELKTV
                     WLVDDDVDIFDMNDVVWTMNTRFQGDQDIMVLPGMRNHPLDPSERPQYDPKSIRVRGMS
                     SKTVIDGTVPFDMRDQFKRAAFKKVSDWQKYLK"
     CDS             2294..2866
                     /gene_functions="biosynthetic (rule-based-clusters)
                     gallic_acid_met: Flavoprotein"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_3"
                     /sec_met_domain="Flavoprotein (E-value: 1.5e-30, bitscore:
                     97.7, seeds: 91, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKRIIVGITGASGTIYAVNLLQHLHRLPDVEVHLVMSAWAKQNLS
                     LETDMKQSELEALADYVYPVQNQGATIASGSFLTDAMVIVPASMKTIAGIAMGFDDNLI
                     GRAADVTIKEQRQLIIVPRETPLSPIHLDNLAKLAHIGVQIIPPIPAFYQHPQTIQDLI
                     EHHTMKLLDALHIKTETASRWNGASLR"
     CDS             2863..4254
                     /locus_tag="ctg15_4"
                     /transl_table=11
                     /translation="MKKILNKQNIGFLIGIAVGLIVYLAPLSGINEKAQMDLTLSLMTV
                     VWWAFQIAQPAYIGGIYLMLLILTNVATPTQVFAGSWTKSIMWLVMGAYLIAGAVRESG
                     LGERIAYAFIIKFVRSWTGIIVSIFALTFILALLIPHPWPRAFLIMSVMDVVATSAKMP
                     QQDRAKLGLAVFAASCPLSGAFLTGDTSLNPLAIADSGKSVNFVQYFIYMGVPMIIAAI
                     ITMLLFLFLFKPTKKVTIDLDVLKAKQADQGAMTHKEIRVIVWLVIAIGLWLTSGITGI
                     DVGWLTLIVALLMSLPVIGEVLTAKSWSGVPVNVLVFLTSAIAIGQVGDFTGMNKWIAQ
                     TILPSALPHNLYLLALVITVFAMIIHMFMGSVIAVMGITIPAIIAATSSLGVNPLAISL
                     IVFSVVNLHYILPFHNLAILVGSDPETGGGYTQKDVMKLGIPLTAVMFIVALVEVFWFQ
                     LTGLL"
     CDS             complement(4400..5299)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     61.9; E-value: 1.4e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg15_5"
                     /sec_met_domain="LysR_substrate (E-value: 9.7e-33,
                     bitscore: 104.9, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.1e-19, bitscore: 61.9,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNFEDLKIFVALYELKSFSKAAVVLHLSQSALSKRIQHIEAILGS
                     KLVDTSNHRRMLVTEAGERFFFHASKILHQVELMNTDLNSLKSLSNGVLTIGAVPILGQ
                     FGISRLINDFAAQFPKLALHVVEQEGISILKQLLTGDLDMALLRDTQAEVLSTREYVKL
                     DLAKDELQVILAKTNPLAKRPSLSANDLAATTIVSLLSGSGVFEPMQAFFADRHIAPKI
                     IFSSPHIETLLGMVEGSRHVTFLFRQSYQPFANSNFVAKSLTPNICSHLQLVYRRTSNP
                     AILKFADYLSQQVTAEKG"
     CDS             5329..5760
                     /locus_tag="ctg15_6"
                     /transl_table=11
                     /translation="MSDYPVPTYTTTVTQSDVTLIATVTVIGRDLLITITGGDHPHIGD
                     VLTLTKDQPIQTIRYPSHDNRFHKDDLLALPSAKALQPLLPGSCTILAGLHIDHISKVQ
                     IQAALDLSHKLAPKLTTWLKHQTFATSRPHYYGPDESPA"
     CDS             complement(5823..6260)
                     /locus_tag="ctg15_7"
                     /transl_table=11
                     /translation="VTVSLGILVKKLNNDLQRYADREAKQLGLTQVQMSIIDFLARQGT
                     KRPLYQTDVEHEFNIQKSSATALLQLMERKELIVRVPSKQDGRYKAIQLTEKSQKVAAY
                     IRHFFDQNDAFLRNALGEDAEVVVNALEKLQTTMAAKLADH"
     CDS             6393..7775
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 143.3; E-value: 2.9e-44)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_8"
                     /sec_met_domain="MFS_1 (E-value: 2.2e-44, bitscore: 143.3,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRKVTPKLYLSILATGLMAFCGVLIETAMNVTFPTLMRQFNVDT
                     GTIQWLTTGYLLIVAIIVPISGFLKRRFTTKQLFLTASAFFILGLALCSVANSFAILLV
                     GRLIQGCGTGIALPLMFNIILEQAPLEKIGFLMGIGTLVTAIAPALGPTYGGVLVDINW
                     HLIFIFLLFVMIAALIMGLFSIQQVSETVHLHLDFLAWLFIAIFFATAILGLNSIEHQP
                     GRALIFAVIAILSLGAYTMRSLHVKEPLINLRLFKNLPFDLHMTTFLIIQIVNVGFAFV
                     LPNYLQLVNHTSSLTAGLLLLPGAALGACMAPMSGKLYDKLGPGRPIFIGLCLQLIGII
                     WLLLEALTAAPVIVLIGYAFIMLGTGFSMGNIMTSGQAQLHQEQTTDGNAIFNTLQQFA
                     GALGTAVVSLIMALAQAGSTSAHNTAIGSQHAFGFLLLLTLIGDVAIFFGLRRRHGETT
                     GK"
     CDS             complement(8008..8736)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldolase_II"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_9"
                     /sec_met_domain="Aldolase_II (E-value: 2.3e-31, bitscore:
                     100.8, seeds: 389, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQYVFENERKDLAEVAREMFVRKNTNVAGGNISVRITADKDID
                     YGSIHIKAGKDYLIMTPTMMSEAWYAKLQPTQILVVDLETGKQIDGVGRLTREINMHEE
                     AYRANDKIRCVYHSHAEESMFWATAGLDMPNVTEVTEEVGPIRVLPYAPACSKELADTV
                     YNGLKAVGDAAKEHIFLLNSHGVLITSEDLHHATEILETVEWNAKIAYQQTVFMKLGLL
                     DSYQSCGKASDGMLKEQVQA"
     CDS             complement(8733..8969)
                     /locus_tag="ctg15_10"
                     /transl_table=11
                     /translation="VSKTLASFLVFIDTIGVSIALLGGSVGLCLLMGLVTIVLYSKVNP
                     VLFGDYDRKRRERINQRRKELLAQRVKNGGFSK"
     CDS             complement(8962..10530)
                     /locus_tag="ctg15_11"
                     /transl_table=11
                     /translation="VTILKDVVNYILNLGGPVFVPLIMLILGLVAGLKFKKSIVAALTL
                     GVAFSGMTLVVNYMMDAISPAAKAMSKLFHLSLNAIDAGWTGVAAITWSYKSAFLFFPL
                     LLAINFVMLTFNWTKTLNVDMWNVWNKIFTYVVVLYFTHNAFFGFLVAGIQIVFELKAG
                     DMWHRHIEDLTGMPGVTVPHFITLFAVILQPLNKLLDFIPIMNKPFDADALQKRIGVWG
                     DNTVMGALIGVLLGFGAGYSVSGSLNLAIKAATAMTLFPMISKLFMTALSPIADAMSGF
                     MQKHFKGREVYIGLDWPILAGRNELWVTVIILVPIMLVFAMILPHNTVLPFAGIINLSF
                     VNAALLLTGANLLRMITLGIITTPIFLYGATYFAPVITNLAKSTGTVKVQAGQQLSWST
                     FEGPDFRLFFAQAFNGKWWAIALAVLWTLGFIWLYRDQNKIKLPSQRYGTLTTPALATT
                     SSTSAADSADADIDLDNLSGLDFSDAKASNESQQSDAKNDDDLDDLGGLDFSQTSHKKK
                     GDQGE"
     CDS             complement(10603..10923)
                     /locus_tag="ctg15_12"
                     /transl_table=11
                     /translation="MAKIVVACGSGVASSEATASRIKDFFESHNVKGVSVDATDFKQLP
                     EVLHNYDVYVWIAKPNQQLEELAKENNIAVVNGMPIFMNMNPEKSYKQIIQALKNMQAA
                     GK"
     CDS             complement(10945..11424)
                     /locus_tag="ctg15_13"
                     /transl_table=11
                     /translation="MDYSTMIHKQLIFLNENQPDRQHLFRAVAEKLQAAGYVKKTYEAA
                     LNRREDEFPTGIVFPEISVMLPHADPEHVIKPFMAIVKNAQPVRVLQMGYNEPEDATAM
                     FFLGITDSSQQVGLLQIFMDLLQNQDFVAKFKATNDRDAMYQLFVDTFEAQTTGK"
     CDS             11630..12424
                     /locus_tag="ctg15_14"
                     /transl_table=11
                     /translation="MSQSPAKFERLNEIIQILRETPEISIAQLSKRMFTSKSTLRRDLI
                     ELENSNIIRRHYGTVQLLQGNNLEFTYEKRRNENARLKRVISRQIAAKIPSNAAFFIDG
                     SSTFFSLPELLHEQVGLHVITNNVNMGMQFNSLNNVETIILGGKMAPRTASTLGATTIN
                     EIQSFRPDFALLSIGSIDADGIYVADPEQAAVKEAMIAAAKCVILGIDSTKFNQSDYIR
                     ITNMDQISEIITDTQPAPEYGNLFDDHHIQLTYPKAHHHLAD"
ORIGIN
        1 gttacgtcac gtggtttaat catgaccgta tttcactcaa taaaaatggc ctgaccccga
       61 ttgaataccg gaatcaagcc gctgtgtaac taaatttcaa actgtctaac ttttttgttg
      121 cacttcagat tagcgacggt ctttttgatt gtcttgtatt atcagcataa tggtgatgat
      181 cagcgcaatc aacgataata tgaaatcacc gaagaccagc atcagcatca acgcatcagc
      241 aacagacaac taggcacttc cttccgtata gattttgatc atcgcgcata ggcgaccacc
      301 tcacaatacg ttggatttgc caaccatcat tcactttctt gtcttgttca tgatgccata
      361 caaaacgtca aaacgcctgc tatctcaatg atttcaggcg ttttttaaat gaactgaacg
      421 tgactcaccg ttttaggctt aattcttgga gcgcttagca ttatcggtaa gtcattgcac
      481 atctcaataa ctgtttgcaa acctgcatga ctatctgtgc gggttttttg ttttggggga
      541 gagagccaaa atatatcaag ccagctttta gttttttcct attgtcatct cattcatttc
      601 gaccagcctc gagttacata tattgactat ttacaagtcg actgtcatta acaaccacat
      661 cttttaagaa atgtcattgc ccttttctta ttccattcag gcataacagc attcaaaact
      721 cgaattgaaa aggtttccaa gccagactag cctagatttt gaaatcaatt cggctggttc
      781 gctgttccgg cctttaggag tgattaatat gacagcatca ccttgggact taagaaaagt
      841 attggatgaa ctaaaacagg atccgcagca atatcatgaa acagatgtgc aagttgatcc
      901 cgatgcagag cttgctggcg tttatcgtta catcggtgcc ggtggaacgg ttgaacgccc
      961 gacacaggaa ggtccggcaa ggatgtttaa caatgttgtc ggcttcccaa cgacaagggt
     1021 tttgatcggt ttaatggcca gtcgcaagcg ggttggcaag atgtttcacc aagactatca
     1081 cacgcttggt cgattcttga acaaagcggt tttaaatcct attcaacccg ttacagtcga
     1141 agaatcagca gcgcctgcgc atgaagtcgt tgccaaggcc agtgacccgg actttgacat
     1201 tagaaaactc gttgcagcac caactaatac gccacaagat gccggccctt acatcacatg
     1261 cggcgtagtt ttgggttcca atatggccaa aacaatgact gatgtgacga ttcatcgcat
     1321 ggttttggaa gataaggaca cgcttggtat ttatatcatg cccggtggtc gccacattgg
     1381 tcattttgct gaagaatatg aaaaagccaa taagccgatg ccggtgacca tcaacatcgg
     1441 cttggatccg gccattacca ttggtgccac ttttgaaccg cctaccacgc cgcttggcta
     1501 cgatgaacta ggagttgccg gagccattcg tcaagaaccc gtgcaactgg ttcaggctgt
     1561 gaccgtcgat gaaaaagcca ttgcccgttc agaatttaca ctggaaggct atatcatgcc
     1621 taacacgcgt atccaagaag acatcaatac ccataccggc aaagccatgc cagaatttcc
     1681 cggctatgac ggtgatgcca atccggcttt acaggtaatt aaagtgacgg ctgtaaccca
     1741 tcggcgcgac catcccatta tgcaaagtgt catcggacct agtgaagaac atgtctccat
     1801 ggccggtatt ccaaccgaag ccagcatttt gcaacttgtt gatcgtgcca tccccggcaa
     1861 ggtcaagaat gtgtacaatc ccccagctgg tggcggcaaa ctcatgacca tcatgcaaat
     1921 tcacaaagat aatccagctg atgaagggat tcaacgtcaa gctgcattac tcgctttttc
     1981 ggcattcaaa gaactaaaaa ctgtttggct ggtcgatgat gatgtcgaca tttttgacat
     2041 gaatgatgtt gtctggacaa tgaatacgcg ttttcaaggt gatcaggaca tcatggtatt
     2101 acctggcatg cgcaaccatc cgcttgatcc atcagaacga ccgcaatatg atcccaagtc
     2161 tattcgggta cgcggaatga gttcaaaaac cgtcattgat ggtaccgtcc catttgatat
     2221 gcgcgatcaa ttcaaacgag cagcctttaa aaaagtttcc gactggcaaa aatatttgaa
     2281 ataggtgatt gaattgaaac gtattatcgt agggattacc ggggcatccg gaactattta
     2341 cgctgttaac ctgctccagc atttacatcg cctgcctgat gtcgaagttc atttggtgat
     2401 gagtgcctgg gcaaagcaaa acctgtcact tgagaccgac atgaaacaaa gcgaactcga
     2461 agctttggca gattatgttt atcctgttca aaaccaaggg gcaaccattg caagcggcag
     2521 ttttttaacc gatgcaatgg tcattgtccc ggcaagtatg aaaaccattg cgggcattgc
     2581 gatgggcttt gatgataatc tcattggacg agcagccgat gtcacgatta aagaacagcg
     2641 gcaattgatt attgtgccgc gggaaacacc gcttagtcca attcatctgg ataacctcgc
     2701 taaactagcc cacattggcg ttcaaatcat tccgcctatt ccggctttct atcagcatcc
     2761 ccaaaccatc caggatttaa tcgagcatca caccatgaaa ttattagatg ccttgcatat
     2821 taaaaccgaa accgctagtc gctggaatgg agcgtcgtta agatgaaaaa aattctcaat
     2881 aaacagaaca tcggttttct catcggcatt gcggtgggcc tcattgttta cctggcccca
     2941 ttaagcggca tcaatgaaaa agcacaaatg gatcttactt tgagtttaat gaccgttgtt
     3001 tggtgggcat tccagattgc acagccggct tatattggcg gtatttatct gatgttgctg
     3061 atcttgacga atgttgcaac cccgacacag gtatttgcgg gatcgtggac caagtcaatt
     3121 atgtggttag tgatgggcgc ttatttaatt gccggtgctg tccgcgaatc aggcctaggt
     3181 gaacgtattg cctatgcttt cattatcaaa tttgttcgca gttggaccgg tattatcgtc
     3241 tcaatctttg ccttaacctt catccttgct ttactgattc cgcatccctg gccccgtgcc
     3301 ttcttgatca tgtccgtgat ggatgtggtg gcaaccagcg ccaaaatgcc acaacaggat
     3361 cgagctaaac ttggactagc cgtttttgcc gcttcctgtc ctctttccgg tgcttttcta
     3421 accggggata catcgctcaa ccccttagca attgccgatt ctggcaaaag cgtcaacttt
     3481 gtccaatatt ttatttacat gggggttccg atgatcattg ccgcgatcat cacgatgctg
     3541 ctctttcttt tcctcttcaa accaaccaaa aaagtcacga ttgaccttga tgttctgaaa
     3601 gccaagcagg ccgatcaagg ggcaatgacg cataaagaaa ttcgagtgat cgtctggctt
     3661 gtcattgcca tcggtttatg gttaaccagt ggcatcactg gtattgacgt tggctggtta
     3721 actttgattg tcgccttgct gatgagtctg ccggttatcg gtgaggtctt gacggcaaaa
     3781 tcatggtcag gtgttcccgt caatgtcttg gtcttcctga cttcggcaat tgcaattggc
     3841 caagtgggtg attttaccgg catgaataaa tggattgccc aaacgatcct gccttcagcc
     3901 ttaccacata atctctactt actggcactg gtcattaccg tttttgcgat gatcattcac
     3961 atgttcatgg gttcggttat tgccgtcatg ggtattacaa tccctgccat tatcgcggca
     4021 acctcgtcac ttggggttaa tccgctggca atttcattaa tcgtcttttc tgtggttaat
     4081 ttgcactaca tcttgccgtt ccataacctt gctatccttg tcggttccga tccagaaact
     4141 ggcggtggct atacgcaaaa agatgtcatg aagttaggca ttccgctaac tgccgtcatg
     4201 tttattgttg cgctggtaga agtcttttgg ttccagctga ctggactttt ataacagcgg
     4261 tgcccttgtt aaaagtcaat atcaatgcaa cgtagctcct aaatgatttt tctttagggg
     4321 ctactgctgt atcgttaaaa tcctgactgc tacacaacag tcgaaatatc gtcttgggat
     4381 tttgcaatca cggttaccat taaccttttt cggcggtaac ttgctggctc aagtagtcag
     4441 caaatttaag aattgccgga ttgctagtgc ggcgataaac cagttgcaaa tgactacaaa
     4501 tattcggcgt caatgactta gcaacaaagt tcgaattggc aaacggctgg taagattgac
     4561 ggaacaaaaa ggtaacgtgg cggctgcctt cgaccatccc caaaagtgtc tcgatatgcg
     4621 gactgctaaa gatgattttg ggtgcgatat gacgatccgc aaaaaacgcc tgcattggct
     4681 caaagacacc agagccgctt agcaagctga caatcgttgt ggcggctaaa tcgtttgcag
     4741 acagtgatgg acgttttgct aatggattgg tcttagcgag aataacttgc aactcatctt
     4801 tagccagatc aagtttgaca tattcccgcg tcgataagac ctctgcttgt gtatcacgta
     4861 gcaatgccat atctaaatca ccggtcaaaa gctgcttgag gatgctaatg ccttcctgtt
     4921 cgaccacatg aagtgccagc ttcggaaatt gagcggcaaa atcgtttatt aatcgactga
     4981 tgccaaactg accaagaatt ggaacggcac cgatcgttaa aacaccgttg ctcaaggact
     5041 tcaaactatt taaatccgtg ttcatgagct cgacttggtg caagatctta ctggcgtgaa
     5101 agaaaaaccg ttcaccagcc tccgtgacaa gcatgcggcg atgattgcta gtatccacca
     5161 acttacttcc cagaatagcc tcaatatgct gaatacgctt agacaaggct gattgactaa
     5221 gatgtaaaac caccgctgct ttggaaaaac tcttaagctc atacagtgct acaaatattt
     5281 ttaaatcctc aaaattcaac ttattcacca ccgaaaggaa gctataaaat gtccgactac
     5341 cctgtcccga cttatacgac aaccgtgaca caatctgacg tcactctcat cgccaccgtt
     5401 actgtgatcg gacgtgacct actcattacc attactggcg gcgaccaccc gcatattggc
     5461 gatgttctca cgttaaccaa agatcaaccc attcaaacaa tccgctaccc cagtcatgat
     5521 aacagatttc ataaagatga tttacttgcg cttccaagtg ccaaagcgct gcaaccatta
     5581 ctgcccggaa gctgcaccat tttagcagga ttgcacatcg atcacatcag caaagtacaa
     5641 atccaggctg cattagatct cagccataaa ctagcgccta agttaacaac ttggctaaaa
     5701 catcaaacat ttgcaacgtc aagaccacac tattacggtc ccgatgaatc acctgcttaa
     5761 tcgctcaacc agatccggga attcgttaat ggacgctaat tgttgacttc aaagatgttc
     5821 cctcaatgat ctgctaattt agccgccatc gttgtttgca gtttctcaag cgcattgacg
     5881 actacttccg catcttctcc caaagcgttg cgcaaaaaag catcgttttg gtcaaagaaa
     5941 tgccgaatat atgccgctac tttttgagat ttttccgtta gctgaatcgc tttataccgc
     6001 ccatcttgct tggagggcac acgaacaatc aattccttgc gctccatcag ttgtaacagt
     6061 gccgttgctg aagatttctg gatgttgaat tcatgttcaa cgtccgtctg atacaacggc
     6121 cgtttggttc cttgccgtgc caaaaaatcg atgatgctca tttgtacctg tgttagaccc
     6181 agttgcttag cttcacgatc agcataacgt tgcaggtcat tgtttaattt tttaaccaaa
     6241 atacccagcg atactgtcac gatgtctatc ccctttcagt ttcaatgaaa tctcaggtca
     6301 gcgtttacat taaaattaag ccttgatttc agaaaataag accgctatag tagctatagt
     6361 tcgatataga actatacacg atggaggttt ttatgacaag aaaagtaaca cctaaattat
     6421 acctttcgat tctcgccact ggtctgatgg cgttttgcgg ggtactcatt gaaactgcca
     6481 tgaatgtcac ttttccgact ttaatgcggc agtttaatgt cgatacggga accattcaat
     6541 ggctgacaac cggctatttg ttgatcgttg ccatcatcgt cccgatttcc gggttcttaa
     6601 aacgacgctt cacgactaaa cagctttttc ttaccgccag tgccttcttc atcctcggct
     6661 tagcactgtg cagcgttgca aacagttttg caatcttgct ggtgggacga ctaatccaag
     6721 gctgcgggac ggggattgca ctccccttaa tgtttaacat cattttggaa caggcaccgt
     6781 tagaaaaaat tggttttctc atgggcatcg ggacgttggt aaccgccatt gcgccggctt
     6841 taggcccgac ttatggtggc gtgctggttg acattaactg gcatctgatc tttattttcc
     6901 tgctattcgt catgattgcc gctttgatta tgggactatt ttccatccag caagtctctg
     6961 aaacggttca tcttcatctc gactttttgg cttggttatt cattgcgatt ttctttgcga
     7021 ccgcgattct tggtcttaat agcattgagc accaacccgg ccgcgccttg atctttgccg
     7081 tcattgcaat tttaagcctc ggcgcctaca ccatgcgctc actgcatgtt aaagaaccac
     7141 tgattaattt acggttattc aaaaatcttc cgtttgatct gcacatgacg accttcctca
     7201 tcattcaaat cgtcaatgtc gggtttgcct ttgtcttacc caactacttg cagctcgtga
     7261 accacacaag ttcactaact gccggcctac tcctattacc tggagcggca ctgggcgcat
     7321 gcatggcacc catgagtggg aaattgtacg ataaattagg tcctggacgc cctatcttta
     7381 tcggactatg cttacagctt atcggaatta tctggctact ccttgaagcc ttaaccgcag
     7441 ccccggtcat cgtcttaatc ggctatgcct tcatcatgct aggtaccggc ttttcaatgg
     7501 gcaacattat gacaagcgga caagctcagt tacaccaaga acaaaccact gacggcaatg
     7561 ccatcttcaa caccctacaa caattcgccg gtgcacttgg tactgcggtc gtctcactca
     7621 tcatggcgct ggcccaagcc ggttcaacct ctgctcacaa cactgccatc ggttcccaac
     7681 atgcgtttgg tttcttgctg ctattaaccc tcattggtga tgtcgcgatt ttctttggtt
     7741 tgcggcgacg tcatggtgaa accacaggta aataagcaaa aaatttaacg cttttacaaa
     7801 aagaacgcaa cgaaaaatgc ccacaagcac aatgtttgtg ggcattttag gttggcataa
     7861 atgatgggga ttaccacata acaagagttt tttgacaaaa cgcttacata ccgaaacttt
     7921 gattttttaa gttctgctca gttcttttgc aatcttttag cacaagcagt tatcgtaagc
     7981 gaatggcatg ccaacaaatc gttagcttca ggcctgtacc tgttctttca acatcccatc
     8041 actcgcttta ccgcaagact gataactatc gagcagcccc agcttcatga agaccgtttg
     8101 ctgataggca atttttgcat tccactcaac cgtctccaaa atctcggttg catgatgcaa
     8161 atcttccgac gtaatcaaaa cgccgtggct atttaacaag aaaatgtgtt cctttgcagc
     8221 atcgcccacc gctttgagcc cattatagac agtgtcggca agttcttttg agcaagccgg
     8281 tgcatagggt aatacgcgaa tcggtccgac ttcttcagtg acctcggtaa catttggcat
     8341 atcaaggcca gcagttgccc aaaacattga ttcttcggca tgtgaatggt aaacgcaacg
     8401 gatcttatca ttggcgcgat aagcctcttc atgcatatta atttcccggg tcaaacggcc
     8461 gaccccatca atctgcttgc cagtctcaag atcgactacc aaaatttgag ttggttgtaa
     8521 cttcgcatac caagcttctg acatcatggt aggcgtcata ataagataat ctttgccggc
     8581 cttaatatga atgctgccat aatcaatatc tttatccgcg gtaatacgaa cgctgatatt
     8641 gccaccagcg acattcgtat tctttcgcac aaacatttcg cgcgctactt ctgccaaatc
     8701 cttacgctca ttttcaaata catactgttc agtcattttg aaaatcctcc attttttaca
     8761 cgctgagcca acaactcttt acgacgttgg ttaattcgtt cgcgtcgctt gcggtcataa
     8821 tcaccgaaca aaacgggatt aactttgcta tacaatacga tggtaacgag gcccatcagg
     8881 aggcaaagcc cgacactacc gccaagcaac gcaattgaaa cgccgatggt atcaatgaaa
     8941 accagaaaag atgctaaggt cttactcacc ttgatcaccc ttcttcttat gacttgtctg
     9001 actaaaatcc aacccgccaa gatcgtctaa atcatcatca tttttagcat ctgactgctg
     9061 gctctcattt gaagcctttg catcgctgaa gtctaaaccg ctaagattgt ctaaatcgat
     9121 atctgcatca gcgctatctg ctgctgacgt tgagcttgtc gttgctagag caggtgtcgt
     9181 caaggtgccg taacgttgac ttggtaattt gattttattc tgatcacggt atagccaaat
     9241 gaatcccaac gtccataaaa ctgctaaagc aatcgcccac cacttgccat taaatgcttg
     9301 agcaaagaag agtcggaaat cgggtccttc aaaagttgac cacgaaagct gttgccctgc
     9361 ttgaactttg acggttccgg ttgactttgc caggttcgta atgaccggcg caaaataagt
     9421 cgcaccatag aggaaaatcg gtgttgtgat aatgcccaag gtgatcattc gcaataagtt
     9481 tgcccctgtc agcaacagcg cagcattcac aaacgatagg ttaataatgc cggcaaaagg
     9541 caaaaccgta ttatgcggca aaatcattgc gaagacgagc atgattggaa ccaagataat
     9601 aacagtcacc cataattcgt tccggccagc gagtattggc caatcaagtc cgatataaac
     9661 ttcacgaccc ttgaagtgtt tctgcataaa tccactcatc gcatcggcaa tcggtgacag
     9721 tgccgtcata aacagtttag aaatcatcgg gaacaacgtc atggcagtcg cggctttgat
     9781 tgccagattc aatgaaccgg agacggaata accagcgcca aatcctaaca gtaccccgat
     9841 caacgcaccc atcactgtgt tgtcacccca aacaccgata cgtttttgta aggcatccgc
     9901 gtcaaacggt ttattcataa tcgggatgaa atcaagtaac ttatttaacg gttgaagaat
     9961 caccgcaaac aaagtaataa aatgtggcac tgttacccca ggcatacccg tcagatcctc
    10021 aatatgtcga tgccacatat cacctgcctt gagctcaaac acaatctgaa tccctgcaac
    10081 caagaatcca aagaaagcgt tatgcgtgaa gtaaagcacc acgacataag tgaaaatctt
    10141 gttccaaacg ttccacatat ccacgtttaa tgttttcgtc caattaaacg tcaacatcac
    10201 aaagttaatc gctaataata acgggaaaaa cagaaatgcc gatttatatg accatgtgat
    10261 agccgcaaca ccggtccagc cagcatcaat cgcgtttaaa cttaggtgga acaactttga
    10321 catagctttg gcagccggtg aaattgcatc catcatgtag ttaacaacca aggtcatccc
    10381 cgaaaaggca acccctaaag ttaacgctgc cacaatcgat tttttaaact tcaacccggc
    10441 aaccaggcct agaatcagca tgattaacgg aacaaacacc ggtcccccaa gattcaaaat
    10501 ataattaacg acatctttta agatcgtcac agttttctac ctcctcaaaa agtgagcacg
    10561 agccgccata tgctgacaca tctagcgtcc ccgtttaccc aactactttc cggcagcctg
    10621 catgtttttt aatgcctgaa taatttgttt atatgacttt tcaggattca tattcataaa
    10681 aattggcata ccatttacaa ccgcgatatt attttccttg gctagttcct ctaattgttg
    10741 attcggtttt gcaatccaaa catagacatc gtaattatgc agaacttccg gtaactgctt
    10801 aaaatcagta gcatcaaccg atacgccttt aacattgtga ctttcgaaaa aatccttaat
    10861 tcgactggca gttgcttcac ttgatgcaac gcctgatcca catgcaacaa caatttttgc
    10921 catgatcttt acgctccttt ttaattattt tcctgtggtt tgtgcttcaa atgtatcgac
    10981 aaaaagttga tacatcgcat cacggtcatt tgtcgcttta aacttggcga caaaatcctg
    11041 attttgtagt aaatccatga aaatctgtaa gaggcctacc tgctgactcg aatctgtaat
    11101 acccaagaaa aacatggcag tcgcatcttc cggctcgttg tagcccatct gcagcacccg
    11161 aaccggctga gcgttcttta caatcgccat aaacggttta atgacatgct caggatcagc
    11221 atgcggcaac atgacggata tctcaggaaa gacaatgccg gttggaaatt cgtcttcgcg
    11281 gcgattcaaa gctgcctcgt aggttttctt tacatatccg gcagcttgaa gcttctctgc
    11341 aaccgctcga aataaatgct gacggtctgg ctgattttca tttaagaaaa tcagctgttt
    11401 gtgaatcatt gtgctataat ccataactag ctcacctcaa tcgaatattt aaaccaaaag
    11461 ttttgaacct ttttgaatct tttaacttat ttcactttca atgctaaagc gctttcatgt
    11521 gcgtgtctat agtatttgta aggtttcatc aaggttgaga agtgttcaca aaatgccgct
    11581 catcctgttc aaatcggttc aataaaattc aattgaggga gcgtttgtaa tgtcacaaag
    11641 tccagcaaaa ttcgagcgtc tgaatgaaat cattcagatt ctacgcgaaa caccagagat
    11701 cagtattgcg caactaagca agcgaatgtt caccagtaag tccactctga gacgtgacct
    11761 tatcgagctt gaaaacagca atatcatccg gcggcactat ggtacggtgc agttactgca
    11821 aggaaacaat ctggaattta cgtatgaaaa aagacgtaac gaaaacgcac gtcttaaacg
    11881 cgtcattagt cgccaaattg ccgcgaagat tcccagcaat gcagctttct ttatcgatgg
    11941 tagttccacc tttttcagtc tgcccgagct tctacacgaa caagtcggct tgcacgtcat
    12001 taccaataac gtaaacatgg ggatgcaatt taattcatta aacaatgtcg aaacgattat
    12061 tcttggtggc aaaatggctc caagaactgc ttcaactttg ggcgcaacga cgataaacga
    12121 aattcaaagc tttcgtcccg actttgccct gctttcaata ggctcgattg atgctgacgg
    12181 tatctatgta gctgacccag agcaagcagc cgttaaagaa gccatgatag ctgctgcaaa
    12241 atgcgtcatt cttggcatcg attcaaccaa attcaatcaa agtgactaca ttcgtatcac
    12301 aaatatggat caaatcagtg agattatcac tgatacgcaa cccgcgccag aatacggaaa
    12361 tttgtttgat gatcatcata ttcaactcac ttatccgaaa gcgcatcatc atttggccga
    12421 ctgaaataac tcgctgtctt attcatacct gatagctgta aacaaaatag acgctagtaa
    12481 aaccaacttg ggcttactaa cgtctatttg ttatcgttaa aagatgatgt tcccgcggtt
    12541 ccccatccct aagtatcgcg ctgaaattgc agtcagaaaa tccgctcact tttaacaagc
    12601 acctttcctc caactttcat ccacaacccc aaaagcccac caattgcctt caacaatcag
    12661 tgggctcttt agagtgtgtt taggaggtat cctaccatga gcagataacg ttacactttt
    12721 agcgttacct gactgatgag tgaatcaccg tgaagaaagg ctgggttagg cgttaagtca
    12781 aaccgtttgg ccagttgttc cagattttca tccgtgattt cgttgatgat gcggccgcct
    12841 tgagcctgaa tggcggtgta gattgt
//
