LOCUS       c00360_JAIZVS0..       11138 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAIZVS010000350.1 Lacticaseibacillus paracasei strain CJNU 1877
            NODE_628_length_11108_cov_9.279168, whole genome shotgun sequence.
ACCESSION   JAIZVS010000350
VERSION     JAIZVS010000350
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 02:57:41
            Original ID  :: JAIZVS010000350.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11138
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11138
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[24:5725]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      25..5725
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..11138
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11138
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             25..1206
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: Thiolase_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: Thiolase_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg360_1"
                     /sec_met_domain="Thiolase_N (E-value: 8.1e-95, bitscore:
                     306.4, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 2.2e-44, bitscore:
                     139.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEVVILSAKRTPIGKLGGDLAGASAVDLGVAAAQAAIKAARIDP
                     ALLNQAIFGNVMQAGSGQNVARQIGLKSGMATSSTAMTVNEVCGSGLKAVRLGQAAIQL
                     GEADAVLVGGTESMSQVPYYAEAVRSGHKFGDTTLVDGLSRDGLNDAFSQQPMGITAEN
                     VATQFNVSRQEQDEFALRSHLRAAAAAAEGRFKSQIAPVTIAARHGDVIVDRDSAIRPD
                     TSLAKLAQLPPVFEVGGTVTAGNASGINDGAAALILMAKSKAEQLGLHYLATITGFAEV
                     GIDPAIMGYAPKLAIDKILQATGGSIAAIDQIELNEAFASQSVAVARDLGLKDEQFNIN
                     GGALALGHPLGASGARILISLLYDLAERNQRQGIAALCVGGGIGIAMQIAMHV"
     CDS             1218..2498
                     /locus_tag="ctg360_2"
                     /transl_table=11
                     /translation="MKFYELSPEKRRDQLVQEGWLTTQDAALLAGTHSLPEVTGARLIE
                     NAIGEFPLPLGVARNLLVNGQLHQVPIADEEPSVIAAASNGARLATANGGVRTHVAAHR
                     VVAEVVLTNLTDLVQARQTILAHQTDIQKVIAVAHPSMIQRGGGLDQLTVESLGAQFLK
                     IRLTLDPQQGMGANYANTVAEAVAAAVTSWVDGDVLVSILTNAPTELVTAEVSLEPVSL
                     ATKAVSGDVIAKKIVQLSELAFVDAERAVTHNKGILNGIIGAVLATGNDTRAVAASIDA
                     FACASGRYQPLSRWYMDQGHLVGHLQLPLPMGAVGGAIGALPMAQVVRRLGGYQNLAIM
                     QQVIAALGLVQNLAAMRALAGPGIQAGHMKLQANALAIAAGATETELPMLVNALRQGSM
                     DLKHAQQYLTTIRLNKKVGQSKDENRD"
     CDS             2482..3648
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ACP_syn_III"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg360_3"
                     /sec_met_domain="ACP_syn_III (E-value: 1.3e-09, bitscore:
                     27.4, seeds: 136, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIGIDAIAMDTPDFYVDLVKLAQVRGDDPDKYTIGIGQDEQAVP
                     PSSQDIVTMGANAATKLLTPAIRASLGMVLVGTESGVDASKSAALFIHDLLALPEWVRA
                     VELKEACYGGTAALMMARDYIAAHPDKTVLVIAADIARYGLATAGEVTQGAGAVAMLIK
                     AEPHIMTIEDDSVYRSESIDDFWRPVYQDTVIAQGKYSTEQYLAFFQAIWSRYQTQRHH
                     TASDFAAMTFHLPYTKMGKKALKLVLPDTDEATGERLQRRFEASTRYCRRVGNIYTGSL
                     YLGLLSLLDNDTSLKAGDRIGLFSYGSGAVAEFFSGILQPDFAAQLHAANHAKMLADRQ
                     ELTVPEYEAVFSDKVPYDPEDYRSDPTYYHGQFVLTGVIGQERQYQQR"
     CDS             3971..5725
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg360_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.6e-40, bitscore:
                     126.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEKINAADAMIKVLEDWGIHNIYGLPGGSFDSTMNALYNRRHTI
                     NYVQVRHEEVGALAAAGEAKVTGRIGATFGSAGPGAVHLLNGLYDAQYDNVPVLALVGQ
                     VPTAAMNTNYFQEMNENPMFADVSVYNRTAMTAEQLPHVVDEAIRQAYKHNGVAVVTIP
                     KDLGWTQIDDNYVSSANLYQKPLLPDPDPDQVAAAWDILKDAKKPILYVGNGARGARDE
                     IIAFSEKTHIPIITTALAKGIVPDDYKANMGSAGRVASKPGVEVARGADTVLFLGSDFP
                     FQPYFIAPNAKYIQVDIDGSKFGRRHTVDLAVLADAKKFIKALSEKADQLPESAWYRAA
                     LANKENWREWMTSFEDDGSTPLRVEPIFKLINEMAEKDAIFQVDVGNVTINGMRYLKTN
                     DDQVFTTSGWYATMGYALPAAIGAQAEFPDRQVWSISGDGGFAMVMQDILTQVKYHMPI
                     INVVLTNESLGFIEAEQDDTQQPHSGVDLIDADYGKAAEALGAQGFEVHNLDELKAAFA
                     KAKDRKGPVVIDVKISDLRPIPVEQLVLDKQTQDPAAVDAFVKKYHAESLIPFRQLLED
                     AEKPVANA"
     CDS             complement(5822..6304)
                     /locus_tag="ctg360_5"
                     /transl_table=11
                     /translation="MKIYFANALFSHADFNYNAQLAAQIRRALPDVDMYVPQENAAINN
                     KEAYADSKMIAEADTKRLLSADLMIAILDGPVIDNGVASEIGVAYAAKIPILGLYTDSR
                     RLGAANQQKLGALQQVAENQFHYLNLYTTGLIKLNGAILTDESALIEAIKASQNGE"
     CDS             complement(6590..7957)
                     /locus_tag="ctg360_6"
                     /transl_table=11
                     /translation="MAVTVKIGQRFPLTIKRLDINGAGIGYYQRKITFVTGALPQEVVV
                     AEVTGIHDRYLEAKVHKIRTASPNRVTPAEPLFGQIGGVELNHLAYPAQLRFKRDVVAQ
                     SLAKFKPTGWTHYDLRPTIGMAQPTHYRNKAQFPVRVIDGHVRAGLYAPNSHHLIPLTK
                     FLTQAPLTMKVVTTLCQILKQLQIPIYNEKKRSGIVKTLVVRESFATKEVQVTFITNSP
                     KLPHEGELLNAIATQLPMVVSIAQNINPGETSLIWGKESRLLAGLPYIQETLLGRTFQL
                     SPQAFLQLNPKQTETLYTLAAKALDLGPHDTLIDAYCGIGTVGISLAKGNQPIYGMDTI
                     AEGIADAKANAKANGLTNAHYSVGKAEDIFPKWVQEGMKPDAVIVDPPRAGLERAFIDA
                     LLELDPPKFVYISCNPSTLARDLVFLTKRYKVDWIQSIDMFPQTARCEAVVKFTRA"
     CDS             8071..8409
                     /locus_tag="ctg360_7"
                     /transl_table=11
                     /translation="MTATVWQNDTPHTIRVGETLDLKVQRGDKITYKVGRFNAIHTIDY
                     QSPDAQFEIQINRSLQNAYFVVMFAMVVFLWFNRNFSQTILIAAVILGLAGYEALVYFV
                     GYTAKPIH"
     CDS             complement(8403..9938)
                     /locus_tag="ctg360_8"
                     /transl_table=11
                     /translation="MFEASFFDRHSLINYQLFRAMKTLQQTTMSINTLSRNTGLSYSQT
                     YTAFQTVLAQLNQILPDKKIDESNFAAVLPDVSIDRYRFSLLKNSLPFEFFDGVFKNPH
                     SDFHAFKQHHQTSISTLRRRISPFRDYLADNGVTLNSTTWAIEGDELHIRLAMFTFFTL
                     AYRGAGWPFSSAEEREAKALLKVINQTKQAFLVSPIQPMSKEALLILAIQMLRINCGHA
                     LLPNRRMQLLFDGETELPDLIFTPDYFPNLSASELKAEKQYYYFSRMYFMTVTRQPHQI
                     DYQIMTHFQSKDNLVNRFVRHLVTSLNNQLKETKSQLIAENQVMIANLYRLSFTEYVLN
                     GHFSQRLDFASALHDEARTSQLTAKIRDCLKRIPKMAPESIYADFTSQFINGLYILVND
                     NYPELNRDMQMVVNVLIEHDSFVKRDLLNFLNDLGFIRVVPPTEAINPDLIITTLTKPK
                     RVIPCMGHPFDPTVPLITWSKEPSDQDYFHLFQRLKRLQREQRTAADTNQTRQ"
     CDS             10012..10806
                     /locus_tag="ctg360_9"
                     /transl_table=11
                     /translation="MSEITKITAQKRRGRYNIFIDGTYAFPVSETTLVDYRLAKGMVLT
                     AETIAQIKSSEVTAMGLEIGLTYISHQSRTSKEVSDRLAKEDLPADVIQKVLTRLTDLG
                     FLDDADYAHRYIEEHLKMGELGPRTLQHKLQQKGLKPDLLANELAAIPTTAWLDAAVRA
                     GQKNLRHHQHRAYKDQLQRLRVALMQKGFDDTTIQTAIATIDPQPDPEAESDLLKLEAA
                     KQWRLKAKYGDRERKQKVKTTLFRKGFDVEAIDEVLNDLAES"
     CDS             complement(10879..11136)
                     /locus_tag="ctg360_10"
                     /transl_table=11
                     /translation="VTPGAMQTTVMFITLNSERVAFFRDPHTKPAFLEISFFIIAEHGQ
                     ARLETSKRVKQPDKNPVYKPASCVIARLCSFVPEVDLLQQ"
ORIGIN
        1 gttcacgctc tttaggaggt catcatggaa gaagttgtga ttctaagtgc caaacggacg
       61 ccgattggta agttgggtgg tgatttggct ggcgccagtg ccgttgattt aggggttgcg
      121 gcagcgcagg cggcgattaa ggctgcacga attgacccag cgttactcaa ccaggcgatc
      181 tttggtaatg tcatgcaggc tggttctggg cagaatgttg cccgacaaat cggattaaaa
      241 agcggtatgg ccactagcag cacggcgatg actgtcaatg aagtctgtgg ctcaggcctg
      301 aaggcagtgc ggcttgggca agctgccatt caactcggcg aggctgacgc ggtgcttgtg
      361 ggcggtaccg aaagcatgag tcaagtacct tattacgccg aagcggttcg ttcaggccac
      421 aaatttggcg atacaacgct ggttgacggt ttgagtcgcg atggattaaa tgatgccttc
      481 agtcagcagc caatgggaat cacggcggaa aatgtggcga cacaatttaa cgtcagtcgt
      541 caggagcaag atgagtttgc tctccgttcg catttacgcg ccgcggccgc cgcagctgag
      601 ggtcggttta agagtcagat cgccccagtg acgattgctg cccgtcacgg ggatgtcatc
      661 gtagatcgtg attcagccat tcggcccgat acgtcattgg ctaaattagc ccaattaccg
      721 cctgtttttg aagtcggcgg tactgttaca gcaggtaacg caagcggcat taatgatggc
      781 gcagccgcct tgatcctgat ggcaaaatcg aaagccgaac aactggggct ccattattta
      841 gcgacgatca ctggttttgc cgaggtgggt attgatccgg caattatggg gtatgcgcca
      901 aaactggcga tcgataaaat actgcaggca accggcggct ctatcgcggc aattgatcaa
      961 attgaattga atgaagcatt tgcctcacaa agcgttgctg tggctcgtga ccttggttta
     1021 aaggatgaac aattcaatat caatggtggc gccttagcgt tggggcatcc attgggagct
     1081 tcaggcgctc gaattttaat ctcattattg tacgatctgg ctgaacgtaa tcaacgccaa
     1141 ggtattgccg cattgtgcgt tggcggtggc atcggtatcg ccatgcaaat cgcgatgcat
     1201 gtctgaggga gatcgtgatg aaattttacg agttgtctcc ggaaaaacgc cgtgatcaat
     1261 tggttcaaga agggtggtta acaacacagg atgctgcgtt gttagctggt acgcatagct
     1321 tgcctgaagt cacaggagcg cgtctgatcg aaaatgccat cggcgagttt cctttacccc
     1381 taggcgttgc tcgcaatttg ttggtcaatg gacagctaca tcaagtgcct atagcggatg
     1441 aggaaccttc tgtgattgca gctgccagta atggggccag gcttgcgact gcaaacggcg
     1501 gcgttaggac ccatgtagcg gcgcatcgag tggtcgctga agtagtcctg actaacttga
     1561 ccgacttagt gcaagcaagg caaacgattt tggctcatca gactgatatt cagaaagtca
     1621 ttgcggttgc gcatccttcg atgattcaac gtggcggtgg tcttgatcag ttaacggtcg
     1681 aatcactagg agcacagttc ttgaaaatcc gtttaacgct cgatccgcaa cagggaatgg
     1741 gggccaatta tgcgaataca gttgccgaag cggtcgcagc ggcggtgaca agctgggtag
     1801 acggtgatgt gcttgtcagt attttaacta acgcgccaac agaactcgtg acggctgagg
     1861 tttcacttga gccggtttct ttagcgacga aagctgtttc tggagatgtg attgctaaga
     1921 aaattgttca gcttagcgag ttagcctttg tcgatgctga gcgggcagtg acccacaaca
     1981 agggcattct taacggtatt attggtgctg tattggctac tggcaatgat acccgcgctg
     2041 tcgcagcaag tatcgatgca tttgcatgtg cgtctggcag gtatcagcct ttatcgcgct
     2101 ggtatatgga tcagggccat ttagttggtc acttacagct gcccttgccg atgggggcag
     2161 ttggcggggc gatcggtgct ttaccaatgg cgcaggttgt ccgtcggctc ggtgggtatc
     2221 agaatttagc tatcatgcag caagttattg ccgccctcgg gttggtgcaa aatcttgctg
     2281 cgatgcgagc attggctgga ccggggattc aagctggtca catgaagttg caggctaatg
     2341 ccctcgccat tgctgccggg gcaacagaaa cagaattgcc gatgcttgtg aacgcacttc
     2401 gtcaaggtag tatggattta aaacatgcgc aacaatattt aacaaccatt cgtttaaaca
     2461 agaaagtagg ccaatcaaaa gatgaaaatc gggattgatg caatcgctat ggacacccca
     2521 gatttctacg ttgatttagt aaaactcgcg caggttcgag gtgatgatcc ggacaaatat
     2581 acgattggca ttggccaaga cgagcaagcg gtaccacctt ctagccaaga cattgtcacg
     2641 atgggtgcga atgcagcgac aaagttgttg acgccagcga ttcgcgctag cttgggcatg
     2701 gtcttggttg gtactgaaag tggtgttgat gccagtaaat cggctgcatt gtttattcat
     2761 gatttattgg cactccctga gtgggtgcgg gccgttgagt taaaggaagc ttgttatggc
     2821 ggtactgccg cactaatgat ggcgcgtgac tacatcgccg ctcacccaga taaaaccgtt
     2881 ttagtcattg ctgcggatat cgcccggtac ggtttggcaa cagcaggaga agtcacacaa
     2941 ggtgcgggcg cggttgccat gttaatcaaa gcagagccgc acatcatgac cattgaagac
     3001 gattcggttt atcggtctga atctattgac gatttttggc ggccggttta tcaagacaca
     3061 gtaattgcac aaggaaagta ttcaacggaa caatatttag ctttttttca agcaatttgg
     3121 tcacgatacc agacccaacg ccatcacaca gcaagtgatt ttgctgcgat gacattccat
     3181 ttaccgtata ccaaaatggg caagaaagct ttaaagcttg ttctgccgga cacagatgaa
     3241 gccactggcg agcgactgca acggcgcttt gaggcaagca ctcggtactg ccggcgagtt
     3301 ggcaatattt ataccggttc tttgtatttg ggtctgctgt cgttgttgga caatgatact
     3361 agcttgaaag cgggtgaccg gatcggttta ttctcgtatg gctccggggc tgtggcagaa
     3421 ttttttagcg gcatcttgca accggatttt gccgcacaac tgcatgcagc caatcacgct
     3481 aaaatgttgg ctgatcgtca ggaattaacc gttcctgaat acgaagctgt tttcagcgat
     3541 aaggtgcctt atgatccaga agattatcgt agtgatccga cttattatca cggtcagttt
     3601 gttttgaccg gtgtgatcgg tcaagaacgt caatatcagc agcggtaatg cttgacagct
     3661 aataagatga tgaacaggac cgtccctcga cggtcctgtt tttgatccat gatcctgatc
     3721 atcattaagt taatttgtga aaaagattta ccaagcatgt tatggcgtgg tgatgctgta
     3781 ttagttcact tgtttgactg ttatggtgcc gtcacttgct agtttaagcg ctttatgcgc
     3841 taaggtccca atttgggcgt taaggttgct taaaccagat gaaagggctt gcattgttat
     3901 caataaattg ttatactcgt aatcgtaaag aacttacaaa atgtaagtaa taatattgga
     3961 ggcaagtgtc atgacagaaa aaataaacgc cgcagacgca atgatcaagg tgctcgaaga
     4021 ctggggtatc cataatattt atgggttacc gggcggttct tttgatagta ccatgaatgc
     4081 gctgtacaat cgccgtcaca ccattaatta tgttcaggtt cgccatgaag aagtaggcgc
     4141 attggctgct gcaggtgaag ctaaggtaac gggtcgaatc ggggcgacgt ttggttctgc
     4201 cggtcctggt gctgttcatc ttctgaatgg gttgtatgac gcacagtatg ataatgtgcc
     4261 agttttggca ttggtagggc aagtaccaac tgctgccatg aacaccaatt atttccaaga
     4321 aatgaacgag aacccaatgt ttgctgatgt gtctgtatac aaccgtacag ccatgactgc
     4381 tgagcaattg cctcatgttg ttgacgaggc gattcgtcag gcttataagc ataacggggt
     4441 tgccgttgtg acaattccaa aggatttagg ttggacccag attgatgaca attatgtatc
     4501 atcagccaat ctgtaccaga agccgctttt gcctgatcca gacccggatc aggttgccgc
     4561 agcttgggat atcttgaaag atgcgaagaa gccaatcttg tatgttggaa atggcgcgcg
     4621 gggtgcgcgc gacgagatca tcgctttctc agaaaaaacg catattccga tcatcacgac
     4681 tgccttggct aagggaatcg tgcctgatga ttataaggca aacatgggct cggccggccg
     4741 tgtggcttct aaacctggcg ttgaagttgc gcgcggtgct gacaccgtct tgttcttggg
     4801 atcggatttc ccattccagc catactttat agcaccaaat gctaaataca ttcaggttga
     4861 tattgacggt agcaagtttg gccgtcgtca cacggttgac ttagctgttt tggccgatgc
     4921 taagaagttc atcaaggcac tgagcgaaaa ggctgatcaa ttgccagaaa gcgcttggta
     4981 tcgggctgct ctggccaaca aggaaaattg gcgcgagtgg atgacttcat ttgaagatga
     5041 tggctccacg ccactgcgcg ttgaaccaat cttcaaattg atcaatgaga tggccgaaaa
     5101 agatgccatt ttccaagtag acgttggcaa tgttaccatc aatgggatgc gttatctgaa
     5161 gaccaatgat gatcaagtgt tcacgacgtc tggctggtat gcgacaatgg gttatgcctt
     5221 gccagcagcg attggtgcgc aagcggaatt ccctgatcgg caagtttggt caatttctgg
     5281 tgatggtgga tttgccatgg tcatgcagga tattctgaca caggtcaaat atcatatgcc
     5341 aatcatcaac gttgttttga cgaatgagag tttgggcttt attgaagctg aacaggatga
     5401 cacgcaacag ccgcactccg gggttgattt aattgatgcc gattatggta aggcagctga
     5461 agcgttaggt gctcaaggat ttgaagtgca caatctggac gaattgaaag ccgcatttgc
     5521 taaggcaaaa gatcgtaagg gtccggttgt cattgatgtg aagatttctg atcttcggcc
     5581 aattccggtt gaacaacttg ttttggacaa gcaaactcag gatcctgctg ctgtggatgc
     5641 ttttgtgaag aaatatcatg cagaaagtct gattccattc cgacagttac tggaagatgc
     5701 ggagaaaccg gttgctaatg cttaatgaca aaatgatcta aaaaacttcc tgtcaacgca
     5761 cgatcatgtg tgattggcag gaagtttttt aggtttgcga aaagaatgct tttgggttaa
     5821 atcattcgcc gttttgactt gctttaatgg cttcaatcag agcggattca tctgttaaaa
     5881 tagcgccgtt aagtttaatt aaaccagtgg tatacagatt gagatagtga aactggtttt
     5941 ctgcaacttg ttgcaaagca ccgagctttt gttgattggc ggcgcctaac cgtcgactgt
     6001 ccgtgtaaag acccaaaata ggaatcttag cagcataggc aacgccgatt tcactagcga
     6061 ccccgttatc aatcacgggg ccatcgagaa tggcaatcat caagtcagct gacagcagcc
     6121 gcttggtgtc ggcttcggca atcattttcg aatcggcgta tgcctctttg ttgttgatcg
     6181 cggcattttc ttgaggcacg tacatgtcaa catctggtaa ggcgcggcga atttgggcag
     6241 cgagttgcgc attgtaatta aaatcagcat gactgaacaa ggcgttagca aagtaaattt
     6301 tcatttttta agacctcgtc tgtagtttgc gggattgttg gtttgggtgg ggtgccgtga
     6361 agtggtggcc tgatgaaacg cgttcatagt cgcaaaatct gacacataca gaccttgaac
     6421 ctaaacggcc gctttatggt tcggcttcta aacgcggctg ttcacgccct ttttgaaacg
     6481 cgttcacagc cgcagaaacc tgcacataag gacctcaagc cgtaaccagc caaagcccgg
     6541 ctggttacag cttgaggccg cttatgttac ggttcctaaa cgcagctgtt cacgctcttg
     6601 taaattttac cactgcttcg catcgtgctg tttgtggaaa catgtcgatg ctttgaatcc
     6661 agtcgacttt gtagcgttta gtgaggaaaa cgagatcacg ggccaaggtg gaagggttgc
     6721 aggaaatgta gacaaatttg ggtggatcga gttcaaggag ggcgtcgatg aaggcacgct
     6781 ctagtccagc tcgtggcggg tcaacgatga ccgcgtctgg tttcatgcct tcctgaaccc
     6841 attttggaaa aatgtcttca gccttgccca ctgaataatg ggcattggtg aggccatttg
     6901 ctttagcatt tgccttggca tcggcaatgc cttccgcaat ggtgtccatt ccgtaaatag
     6961 gttgattgcc ttttgctaaa ctgatgccga ctgttccgat cccacagtac gcatcaatta
     7021 aggtgtcgtg cggccctaaa tcaagtgctt ttgcggccaa tgtataaagt gtctctgttt
     7081 gttttgggtt cagttggaga aatgcttgtg gtgagagttg aaaagtccgg cctaacagtg
     7141 tttcttggat ataagggaga cctgccagta ggcgactttc tttgccccaa attaaggatg
     7201 tttcgccagg attgatattc tgggcgatgc tgaccaccat gggaagctga gtggcgatgg
     7261 cattgagcaa ttcgccttcg tgcggtaatt ttggactgtt cgtgatgaac gtgacctgga
     7321 cttctttcgt tgcaaatgat tcgcgaacaa ccaatgtttt gacaattccg gagcgctttt
     7381 tctcgttata gatcgggatc tgaagctgtt tgagaatctg acacaaggtt gtcacgactt
     7441 tcattgtcag cggtgcttgg gtcagaaact tggttaaagg gatgagatga tgtgagtttg
     7501 gagcataaag acctgcgcgt acgtgaccat caatgacccg aacaggaaat tgggccttgt
     7561 ttcgatagtg cgttggttgt gccatgccaa tcgtcggccg caaatcataa tgagtccagc
     7621 cagtcggttt aaatttggca agcgattgtg cgacgacatc tcgcttaaat cgcaattgcg
     7681 ccggataagc gagatgattg agttcgaccc cgccgatttg tccaaatagc ggttctgccg
     7741 gggttacgcg atttggtgac gccgtccgaa ttttatgaac tttggcctca agataacggt
     7801 cgtgaatccc agtaacctct gcgacgacga cctcttgagg tagtgcaccg gtaacaaacg
     7861 taattttccg ttgataataa ccgatacctg cgccattaat gtctagacgc ttgatggtca
     7921 ggggaaaacg ctgaccgatt ttgacagtga ctgccatgaa atgctccttt gctttgagaa
     7981 atggtgacga ggcttaagaa tgtttagtat aatgaatcat cgggaggatt taatgtgaaa
     8041 atcaattatt cgaatacgat gagtagaaaa atgacagcaa cggtgtggca aaatgacacg
     8101 ccgcatacga tacgagttgg cgagacgcta gacttaaagg tgcaacgcgg cgataagatt
     8161 acttataaag ttggtcggtt taatgcgatc cacacgattg actatcaaag tccggatgcc
     8221 caatttgaaa ttcaaatcaa tcgcagccta caaaatgcct attttgttgt gatgtttgcg
     8281 atggtagtct ttctttggtt taatcgcaac ttcagtcaaa cgattctaat tgcagcggtc
     8341 attttgggac ttgccgggta tgaagcccta gtctactttg tcggctacac ggcaaaaccg
     8401 attcactgac gagtctgatt cgtatcggct gctgttcgtt gctcgcgctg taggcgtttt
     8461 aagcgttgaa aaaggtgaaa atagtcttga tcgctgggtt ccttggacca agtgatcaag
     8521 ggaacagttg gatcaaacgg gtggcccatg caagggatca cccgttttgg ctttgtcagc
     8581 gttgtaatga tcaaatcagg attgatcgcc tcggttggag gcacaacgcg aataaagcct
     8641 aaatcgttta aaaagtttaa gagatcccgt ttgacgaaag aatcatgttc aatcaaaacg
     8701 ttaacgacca tttgcatgtc acgattgagt tcaggataat tatcattgac taatatatag
     8761 agaccattaa taaattggct tgtaaagtct gcgtagattg actcaggcgc cattttggga
     8821 attcgtttca aacagtcgcg aattttggcc gtcaattgac ttgttcgtgc ttcgtcatgc
     8881 aatgccgaag caaaatcaag cctctgacta aaatgaccat tcagcacata ctcggtgaaa
     8941 cttaatcggt aaagattggc tatcatgact tgattttcgg caattaactg acttttggtt
     9001 tcttttaatt ggttattcaa agacgtgacc agatgtcgca caaatcgatt cactaagtta
     9061 tctttacttt gaaaatgggt catgatctga taatcaattt gatgtggttg ccgagtgacg
     9121 gtcataaaat acatacgcga aaaatagtaa tactgttttt ctgcttttaa ttcagaagca
     9181 gataaattgg gaaagtagtc tggcgtaaaa atcaaatctg gcaattcagt ttcaccgtca
     9241 aacaacagct gcattcgccg atttggtaaa agggcgtgcc cacagttgat tcgtaacatc
     9301 tgaatggcga gaataagtaa agcttctttg gacattggtt ggattggtga caccaagaaa
     9361 gcctgctttg tttggttgat taccttgaga agtgcttttg cttcccgctc ttctgcactt
     9421 gaaaatggcc atcctgcccc gcgataggct aatgtaaaaa aggtgaacat ggctaagcgt
     9481 atatgcaatt catcgccttc aatggcccaa gtagtactat ttagcgtgac accattgtca
     9541 gctaagtagt ctcgaaacgg cgaaattcgg cgccgcaacg ttgaaatact tgtttgatgg
     9601 tgctgcttga aggcgtgaaa gtccgaatgc ggattcttga aaaccccatc gaaaaattca
     9661 aatggtagac tgttttttaa tagcgagaac cgataacgat caatcgaaac atcaggcaaa
     9721 actgctgcga agtttgattc gtcaatcttt ttgtcaggta agatttggtt gagctgtgct
     9781 aaaacggtct gaaatgccgt ataagtctgc gaatacgaaa gcccagtatt gcggctaagc
     9841 gtattgatcg acattgtcgt ctgttgtagg gtcttcattg cccggaatag ttgataatta
     9901 attaagctgt gccggtcaaa gaaactggct tcaaacataa cgagcctcca aatttattta
     9961 taaaaagtat aacatagaat ggcaacgtga ttagagaggt gacaggggtt catgagtgaa
    10021 attacaaaga taaccgccca aaaaaggcgt gggcgctata atatttttat tgacgggact
    10081 tacgcatttc cggtgagtga aaccacgctg gtggattacc gcttggccaa aggaatggta
    10141 ttgacagcag agaccattgc ccaaatcaag agcagtgaag tcaccgctat gggactagag
    10201 atcgggctga cctacattag ccaccaaagt cgcacgagca aagaggtcag tgatcggcta
    10261 gctaaagaag acttaccggc tgatgtgatt caaaaggtgc tgacgcgtct gaccgatctg
    10321 ggctttttgg atgatgcaga ttatgcgcat cgttacattg aagagcatct gaaaatgggt
    10381 gaacttgggc cgcgaacgct gcaacataag ctacaacaaa aaggcctcaa gccagacttg
    10441 ttggccaatg agttagctgc tattccaaca acagcatggc tagatgcggc tgttcgcgct
    10501 ggtcagaaga atcttcggca ccaccagcat cgcgcttata aagaccaact gcaacgtctc
    10561 agagtcgctt taatgcaaaa gggattcgat gacactacta tccaaacagc tatcgcaacc
    10621 atcgacccgc aacccgatcc tgaggcagaa agcgacttgc ttaagctgga ggcagccaaa
    10681 caatggcgtc taaaagcgaa atatggtgat cgggagcgca aacaaaaagt taaaacaact
    10741 ttgtttcgta aaggctttga tgtggaagct attgatgaag tgctaaacga cttggcggaa
    10801 agttgatcgt ggttttttga aagatcaagc tatccttttg catgcccttg taagctgccg
    10861 actcttgctg aaaagcgttc actgctgcaa taagtcaacc tcaggcacaa atgaacaaag
    10921 tctggctatc acacatgagg ctggcttata caccggattt ttatcgggct gtttcacacg
    10981 cttgctagtt tctaagcgcg cctgtccatg ctctgctata atgaagaacg aaatttccaa
    11041 gaaagcgggt tttgtatgcg gatccctaaa gaaggcgact cgttcgctat tcaaagttat
    11101 aaacatgacg gtagtctgca tcgcacctgg cgtgacac
//
