LOCUS       c00009_JAKXAR0..       15411 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAKXAR010000106.1 Lactobacillus crispatus strain CM_D08_S828-bin_2
            JEOPHKPD_106, whole genome shotgun sequence.
ACCESSION   JAKXAR010000106
VERSION     JAKXAR010000106
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 10:44:42
            Original ID  :: JAKXAR010000106.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 7679
            Orig. end    :: 23090
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15411
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[12679:18090]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..10411
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..15411
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15411
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(718..1614)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 168.6; E-value:
                     3e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="MLKIEHLNKSFGSTQVLFDVSFSVSDGRILGLVGKNGSGKSTIFH
                     SILKFVDYDGQISIDGHSFNAKDYDNIGYLPEERSLMPKLTISDQVVFLASLKGMPAKK
                     VKEELPDWLSRLAVKGIPMDKIKSLSKGNQQKVQMIATLIHQPKLIILDEPFSGLDPVN
                     VDLMKQLILEEKRKGATIIFSDHDMRNVEELCDDVVMINDGHIVLNGPVNEIKNSFGLT
                     RIFVRTDKSATELSALPGVKDIILQNNGMKLLILADEKYGKDIFNQLSAGQYIQTFDQE
                     PPTLDEIFKMKAGARHE"
     CDS             complement(1632..2054)
                     /locus_tag="ctg9_10"
                     /transl_table=11
                     /translation="MNNEKFARENKRIIEGMGIGALVGPILALVMMYVKTAGSPQPFQI
                     IMSIGAGLAFGLMFGGIMSASLVLNKTVASKIPWQKKVLKLAPQVIGTGVVVASAGVVI
                     TLVTNWGSVDIVKTIFSTDTLWQFFDGVLLGLITIR"
     CDS             complement(2081..2272)
                     /locus_tag="ctg9_11"
                     /transl_table=11
                     /translation="MLYLIYIVLGLLIILAVNYAVTAFLAVHDLLENREKDQLSFGDAF
                     KKYFAKNNIPTKFSDLFN"
     CDS             complement(2629..3168)
                     /locus_tag="ctg9_12"
                     /transl_table=11
                     /translation="MKKLILNLLTIFAWIYQIFCVIGIIMWIVMGGVVLFGIHNPDFRA
                     GFESGRGIKGVSVDNYIGAIVVVLLSLIMMSVAAFLICRYARLIVKNIKQEVYFADSNL
                     NLLKKLLISVAGYTLISIIDYIIFITHRTWFAKSSNNVLYPSGVTTGLLFLAVLYVVYL
                     VFKYGMKVQEDADSII"
     CDS             complement(3173..3355)
                     /locus_tag="ctg9_13"
                     /transl_table=11
                     /translation="MLPEKKRQIGSIIGMLIMMAILVFANLGGTWSVLRITLLVIGVTG
                     VIGSAIYRIIHILRG"
     CDS             complement(3523..3783)
                     /locus_tag="ctg9_14"
                     /transl_table=11
                     /translation="MDFYFLQSVQVNFTIGENKILTERQVRNRSIIAGILALLIGLVWD
                     YFQYKTLSFGTVFWNIVESVAFVIFMNIFMNSYYKKKSKKQ"
     CDS             3838..4887
                     /locus_tag="ctg9_15"
                     /transl_table=11
                     /translation="MDSLHFIMDKRKKGTHLSLEERVIIQTRLKDHCSLRSIAREIGCS
                     PSTIHYEIKRGTVKLYHGNIKRYKAQQGQSVYQNHRQHCGRKSDFLKKHKFIDYVQRHF
                     FEDGWSLDVCSNRCTAVGEFASSDIVCTRTLYNYVDQGLLDIHNYDLPEKLKRNTKLHR
                     VRKNKKKLGRSIEERPKEINKRNEFGHWECDLVLGHKSKDDEVLLTLSERMSREFLILR
                     IPDKTSVSVMQAFKELQRQYSEHWNDIFKTITTDNGSEFADLSQLEDISQTLVYYAHPY
                     TSCDKGTVERHNGLIRRFIPKGEAIDNYSLQDIIDIETWCNSLPRKILAYHTPDEIFEK
                     ELDRIYQTA"
     CDS             complement(5001..5195)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_16"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 8e-09, bitscore:
                     27.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKEMNYKELEKVSGGTNWLGVGGSCLSGFIDALPSGSGMIKGCV
                     EGAVKDFAKQNRHKKHKHR"
     CDS             complement(5213..5464)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_17"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.1e-15,
                     bitscore: 48.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKFETLTYEELSAVFGGNGGKARRRRKITNCAKAIGMGALKDGL
                     KYGIAGTAFGTPIGTVGGAIFGANVGIISGSVSCVSHL"
     CDS             complement(6057..6254)
                     /locus_tag="ctg9_18"
                     /transl_table=11
                     /translation="MKRIIISKDEVLLSGILGGSGSVDDIGLTDTEHMLPLYSKKGGNH
                     KRDVYLENPKFFQSSFHRGR"
     CDS             complement(6255..7559)
                     /locus_tag="ctg9_19"
                     /transl_table=11
                     /translation="MNKKKILMLMLSPAVLLMMNSTIVHADEGNTSQENKSEVVSKTEN
                     DDKNVSESEQKTSSKNEAAQTQNKQEEEPAASEDQNNQSQNTNNQDPNNANEEDSEDDE
                     DEVSVEDYENNVKDFHRVKMQEVKDLLAEKNNQEHLMYIGRPTCYYCRQFSPDLKDFNE
                     IVKGKLLYFNIDAEEGAHEYAFKEIGIPGTPTTMRFINGKIISAWVGGEKTGQELYNFL
                     YSDAANKLVEQAVIKDQPKDDNTTESESNEIPEVTVAEDDQTQSSNDVAITDFVENSVF
                     ENAANVASSTADLTKVTTGNQEYAAPRAETKKKTVKKPVKPKIVATKVKKTAKSHKKNI
                     ILAAVSEKHGSVKENKQFDSVKVQSKPYSAVKNNQNRITKLKRLENDTIKNGSTQSLPS
                     TGEKDNIWGQLIGMISILISLVLGISLGKKTKEEK"
     CDS             complement(7714..8310)
                     /locus_tag="ctg9_20"
                     /transl_table=11
                     /translation="MNNKDYESTEYYSYKFKNFSTMIIIPMAILVLILIVGSFFATRQS
                     TVTSTGIVEPQNTLNIANRNYHEGQIVRRNREKWLVHLDDKQENTVHLFPMIKAKRTVN
                     VVTYFPGNKIGAIKKGQTLYFQVANASGTMDRLVGKVKEIGVYPINLRGNNVYEVICKA
                     KSKKNLKYGMEGNATIITGKSTYFEYFKDKILNQN"
     CDS             complement(8321..10411)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 311.6; E-value:
                     1.8e-94)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_21"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1038.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-34, bitscore:
                     110.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILKKYHSRVFLAHLRHSARTNLEGTTALGLVKTAQAFNLKTEAV
                     KADMSLFDPDADIQYPFIVHVLKQGELLHYYVVIKATKNYLVIADPDPSVGLTKMSKEK
                     FSQEWTGIALFMVPNDDFEPLKEKKQNLWSLFPYMFKQKKLVTNIILAALLMTIISICS
                     SYFLQGLIDTYIPSGTYQTLSILAIGLLIAYVFNSIFSYGQNFLLDVLGQRLSIDLNLQ
                     YIRHIFELPMEFFVTRRTGEITSRFSDASRIIDALASTVISLFLDLSIVIVMGIVLAIQ
                     NSTLFVITLLSLPIYAVVILSFSKKFEKMNNDQMESNAVLSSSVIEDIQGIETIKALNS
                     EQTRYRKIDSQFVDYLKKSFRYSKTESLQSALKTFIQLSLNVIILWVGAKVVMNGQMSI
                     GQLMTFNALLSYFVDPLQSIINLQPTLQSANVAQNRLNEVYMVKSEFQKDAQIRDAKQL
                     AGEIEYHHVDYHYGYGVDVLKDINLKIEPNDKLAIVGMSGSGKSTMVKLLVDFFSPSKG
                     KLTFNGFNSTKVDKHVLRSYVNYVPQTPYIFSGTIKENLLLGSRPDITEKDILKACQIA
                     EIESEIEQLPLQFETKMDENAKILSGGQKQRLTIARALLSPAKILIFDEATSGLDTITE
                     KKVVDNLMKLKDKTIIFIAHRLAIAQRTNNILVVDHGQIVEQGSHEKLMQKHGFYYNLV
                     EN"
     CDS             complement(10607..11407)
                     /locus_tag="ctg9_22"
                     /transl_table=11
                     /translation="MSKFPIIVCDDDKDLANQMAKNINASIQDLIDDNEGYAELNESVT
                     FVANDFAQAVGYIVTNDIKNGIYFLDIELSRESKAKNGVDLAEFIKKNDENAQIIFVTA
                     YDKYAPLTYRRRIGAIDYISKSMSSDKIIQRIEETLRNAFDNLSNRIKFSQRDFTYKIG
                     RRVCKVAEGDILFIEHSTTQHKVHMVTENGEVEYKANITQIDKENPFLAKVSQSSLVNP
                     KNISAIDTKERIIIFDNGQMVTYSRSYKAVVKKLVDKFENIKVE"
     CDS             complement(11400..12728)
                     /locus_tag="ctg9_23"
                     /transl_table=11
                     /translation="MEKIVLFLFLNVFSSLADVWCFFKISRVRSKKRQILFLCIANIFL
                     GLLLSIGNIGVIFTNILETLLFVLYLRKNNTLEILFGSIILVCTLDLLVDIVSDMITQV
                     MSFTLIGQLSLRFLLILMMIVAIKLGNGKIYNYLANQNNKIFVGILAYTYVSTVSISII
                     YIQSKSFTPLTLFFSLYILIQTIFAIFIYHEMTMVQEKLLNKKDQEKLKQQQHQLEEYA
                     SYLEKSEDDLRAFRHDYKNILNSLKVSAQEGNVQEVIQKLDKYTETNLNSKALLKYKDL
                     NHIYVKSIKSIIIPKITELYNLDIPYNFECRNNIRNLPDHVDELDLVRIIGITFDNAIE
                     ESKALIAEKHDIRSAEVQIMVYSDDPDEFEFEIRNKIQNKNISTSQIQQRGFTTKKDHK
                     GLGLANIKEIESKYPDMSISYTIQDGWFDFYMTIDTEDGEEDE"
     CDS             complement(12965..14362)
                     /locus_tag="ctg9_24"
                     /transl_table=11
                     /translation="MFVGRHQELEQLNQAYQENDFQFTVIYGRRRIGKTSLINEFLKDK
                     KSIYYVALEENAEDNLKRFSDAISIFKNTDQGGKEKFANFEECFKEITHLAQKQRVILV
                     IDEFPYLAKAYPTISSMLQSYIDHEFKETNLFLILCGSSMSFMERQVLGYQSPLYGRRT
                     LALKLEPFKLSEAHEMLPKLSKEDAFIINTVCGGVPQYLSYMSDSMSVADNIKKNFLSK
                     SGRLFDEPNNLLQQELRDPTNYNSIINAIASGASKHSKIAQSAHLQTGPLTTYLNNLID
                     LGIVEKKLPVTEQKKSKSKNIVYRICDGMFRFWYTFVGKQTDLIERGLTDLAWVKVQKG
                     LSDFMGPEFEKYSQDFMWSQDMNEKIVPNPFIHLGNWWGTDKRTHQQVELDIVGFSDDE
                     RDGYFGECKWKNEPISRSVLEKLITNSEIFKYPLKHYYLFSKSGFTDSCQELAKKINCQ
                     LFTFEEI"
ORIGIN
        1 actgccacaa aaccaacaac ataaattaac acttgggtga taatttcacc aaaaatacct
       61 aaaatcttcc cagtgaaata atcgccacct ggcatactcg aaaagattac ttccattatc
      121 ttggtaccct tctccgtagc gatatcttgt gctgttactt gcgtataagt gatcacaagc
      181 atgtacaaga taatcagcaa aacccagaag gaaatttgct taacaggatc attatcaaag
      241 ctcttcttat caacatgctt aacttgttgc ttaaattgcg ctcgcgtagc taaagactga
      301 gtctgttttg tcgttagctt ggccttactt aaattcaatt gttgctgggc ggtgtttagg
      361 ctagttagca gctctgattt tagatcactg tccatttttt catcactata gtaagttgca
      421 gctaattgat tattcttttg ttcaattaaa acatagccat cgatatcttc atctttatac
      481 gcctttttag ccttagcttc agtgctatag ttgtcaaagt cttctgactt tttaattgct
      541 tgctttaagg cagaattaga agtaactacc ccgacatagt tgtcatcact gccgccagct
      601 gataccattc cgataacaaa tgaaaagaag acgagcagaa acggtgctaa aatcatcagc
      661 aaatatgacc aagttttcac ttctctacgg taggtttctt ttgcgacaag ccagatctta
      721 ttcatgacgc gcacctgctt tcattttgaa aatctcgtct aaagttggag gttcctggtc
      781 aaaagtctgg atatattgac cggccgaaag ttggttaaaa atatccttac catatttttc
      841 gtctgcaaga ataagcagct tcattccatt gttttgcaaa attatatctt ttacacctgg
      901 taaggctgat aattcagtag cacttttgtc tgtcctgaca aaaattcgag ttaggccaaa
      961 gctgttctta atttcattta ctgggccatt caagacgata tgcccatcat tgatcattac
     1021 gacgtcatcg cacaattctt ccacgttacg catatcatga tcagaaaaaa tgatcgtagc
     1081 gccttttctt ttttcttcca aaatcagctg cttcattaga tcaacattaa caggatctag
     1141 tccactgaat ggttcatcta aaataatcaa tttaggttga tgaattaaag ttgcaatcat
     1201 ctgtactttt tgttggttac ctttagacaa agacttaatc ttatccatgg ggatcccttt
     1261 aacagccaaa cgtgataacc aatcaggcaa ttcttctttt acctttttag ccggcatccc
     1321 tttaaggcta gccaaaaaca ctacctgatc tgaaatagtt aacttaggca tcaaacttcg
     1381 ctcttcaggc agatagccaa tattgtcata atctttagcg ttgaaagaat gtccatcaat
     1441 actaatctgg ccgtcataat caacgaattt caaaatacta tgaaagatcg tcgacttacc
     1501 cgacccattt ttaccaacca gtccaagaat acgcccatct gacacactga agctaacatc
     1561 aaacaaaacc tgtgttgacc cgaagctttt atttaggtgt tctattttta acataatttt
     1621 tcctcaactt tttatctaat ggttattaga cctagaagta caccgtcaaa gaactgccat
     1681 aaagtatcgg ttgaaaaaat tgtttttaca atatcaactg acccccaatt ggttactaaa
     1741 gtaatcacta caccagctga agcaaccact actcctgtac caataacttg aggggcaagt
     1801 ttcaacactt tcttctgcca tggaatcttt gatgcgaccg ttttattaag gactaagctt
     1861 gcggacatga tgccaccaaa cattagaccg aaagccaatc cggctccaat cgacataata
     1921 atttgaaaag gttgaggcga accagcagtc ttaacataca tcatcacaag agctaatatt
     1981 ggtccaacaa gtgctccaat tcccatgcct tcaataattc gtttgttttc acgagcaaat
     2041 ttttcattat tcattgttct tacctcaagg aaattttcag ctaattaaac aaatccgaaa
     2101 acttagtcgg aatgttgttc ttggcgaagt atttcttgaa tgcatcccca aaactcaatt
     2161 gatctttttc tctattttca agcaaatcat gaacagctaa gaatgctgta acggcgtaat
     2221 taacggctaa aatgattaac aaaccgagca caatataaat taagtacagc attgttcttt
     2281 cctccaattc agcgattatc tcccaggaaa taatctttta tccttttaaa ttaatcatat
     2341 ccccatcatt tatgtaaaag gtaaaaccgt ccaattctgt catttttcgg actgattttg
     2401 cattttattc ttcatctttt ttataaacta ataaatcccc tggttgacaa tccaagactt
     2461 cacagatctt gctcaacgtg tcgaagcgaa cgccatgcgc ctttcctgtc ttcagaatcg
     2521 acaggttagc cggcgttata ccaactttct ctgccaactc ctttgaagac atctttcgct
     2581 tcaagagcat aaaatctagt gtcacttcaa tcatctatat caacctttct aaataatcga
     2641 gtctgcatcc tcctgaacct tcattccgta cttgaatacc aagtagacta cgtatagtac
     2701 tgctaggaaa agcaaaccag ttgtcacacc acttgggtat agtacattat tcgaggattt
     2761 agcgaaccaa gtgcggtgag ttatgaaaat aatgtaatct attattgaaa taagggtata
     2821 tccagcaact gaaattaata atttcttgag taaattcaaa ttactatcag caaagtaaac
     2881 ttcttgcttg atattcttaa caattaatct ggcatatcga cagattaaaa aggctgcaac
     2941 gctcatcatg atcagtgata gcaacacaac cactattgca ccgatatagt tatcaactga
     3001 tacgcctttt atacccctac cactttcaaa gccagcacga aaatccggat tatgtatacc
     3061 aaataacaca acacctccca taacgatcca cataattatt cctatcacac aaaatatttg
     3121 gtaaatccaa gcaaaaatcg taagcaaatt caaaattaat tttttcattt ttctatcctc
     3181 tcaaaatatg gatgattctg tatatagcac tgccaattac acccgttact ccaattacta
     3241 ataatgtaat tctaagaaca ctccatgttc cgcctaagtt agcaaacact aagattgcca
     3301 tcattatcag cattccaata attgaaccta tctgtctttt cttttctgga agcatatcta
     3361 tccctctctt ccataaaact atctatctct ttctcgtctt ttataattat tgtattacga
     3421 taatttataa ttgcaataca gaaataaaat atttttttgg gataataaaa aaataccaaa
     3481 ttagtcgtta aactaacttg gtattatgtt ttatcttcca agctactgct ttttactttt
     3541 cttcttatag taagagttca tgaaaatatt cataaagata acaaaggcta cactttcaac
     3601 tatattccaa aatactgttc caaagcttaa tgttttgtac tgaaaatagt cccataccaa
     3661 tcctattaac agggccaaaa taccagcgat gatacttctg tttctaactt ggcgctcggt
     3721 taaaatttta ttttcgccga ttgtaaaatt aacttgaaca ctttgtagaa aataaaagtc
     3781 catttggacc tgtttgatag aatgttaata accacaaaaa catctatgga ggtcaaaatg
     3841 gactcactac attttatcat ggacaagcgc aaaaaaggaa ctcatttatc gctcgaagaa
     3901 cgagtcatta ttcaaactcg tttgaaagat cattgctctt tacgctccat tgcacgagaa
     3961 atcggttgtt ctcctagtac aattcactat gagattaagc gaggaaccgt taagctgtat
     4021 catggcaata tcaaacgtta taaagcccag caaggccaaa gcgtttatca aaaccatcgg
     4081 cagcactgtg gtcgaaaatc tgactttctc aaaaagcaca aatttattga ttacgttcaa
     4141 cggcacttct ttgaagatgg ctggtcactc gatgtctgca gtaatcgctg cactgctgtg
     4201 ggtgaatttg ccagcagcga tattgtctgc accaggacgc tttataatta tgtcgatcaa
     4261 ggtctattag atatacataa ttacgacttg cctgagaagc ttaaacgcaa tactaagctt
     4321 catcgtgttc gcaaaaataa gaaaaaactt ggcagaagca ttgaagaacg tcctaaagag
     4381 atcaataaac gtaatgagtt tggccattgg gaatgcgatt tagttctcgg acataagagc
     4441 aaagatgatg aggtgctgct aaccttatct gagcgtatga gtcgtgagtt cttaattctt
     4501 cgtattcctg acaagacttc tgtcagtgtc atgcaggcct ttaaagaact ccaaaggcaa
     4561 tacagcgaac attggaatga tatctttaaa actattacga ctgacaatgg ctctgaattt
     4621 gcagatctat ctcagctgga agatatttcc caaaccttgg tttattatgc tcatccttat
     4681 acatcttgtg acaaaggaac cgttgaaaga cataatggac tcattcgcag atttattcct
     4741 aagggagagg caatagacaa ttattcacta caagacatca tagacattga aacctggtgc
     4801 aactctttac caagaaagat attggcatat catacaccag atgaaatctt tgaaaaggaa
     4861 ttggatcgta tctatcaaac agcataagtg ttcaatttat tattgcaatt tacgaaaatt
     4921 ttatttttca taatttttac cccattatta tcatatcgaa aaataggaaa tctattaacc
     4981 gaattttcta ttttttaata ttatctatgt ttatgttttt tatgtctatt ttgtttggcg
     5041 aaatctttaa cagcgccttc tacacatcct tttatcatac cacttccgct agggagcgca
     5101 tcaatgaaac ccgataaaca tgatccacct acaccaagcc agttagtgcc accacttact
     5161 ttttctaatt ctttataatt catttctttc atcataaaag ttacctcctt ttttacaaat
     5221 gtgatacaca agaaactgat ccgctaataa tacccacatt agcaccaaat atagctccac
     5281 ctactgtacc aattggagta ccaaatgcag tgcctgcaat gccatatttt agtccatcct
     5341 tcaacgctcc cattccaata gctttagcac aatttgtgat ttttctacgg cgtcttgctt
     5401 taccaccgtt accaccgaaa acagctgaca gttcttcata agttaaagtt tcaaatttgt
     5461 tcatgttttt cccctttata aaacttctaa ttacaatttt cataagtgaa ttaagtttta
     5521 cctctcttca acttacacac taataataca aaacaattta ccttcattgg cgtataatac
     5581 cgatttagca cgaaacaaga tctatttgga aaatatttac caaatcggcc aagttttcgt
     5641 atattagtaa tttacaaagg attcttatta attgttacgc taacttgata ttctgtttta
     5701 taaatccgaa aactagtaaa aacatagaca caatgcactt attatgagaa tggctaacaa
     5761 aaaaatcttc tcatagccaa ggctacaaga agattgccat cacattaatg cataaactga
     5821 tacgcacgct ctttacttta ataaaacatg atcaattata cgactataac atagccactc
     5881 aaaacccaaa acttgagtcg aaatcaaata atcattttta gcatagtaac ctacgaaaaa
     5941 aatcacaagt ttcataggtt tctttgcgtt atcttctaag tattacgata ttttctattg
     6001 gagatatttt tagcctattc gcaccagtat ttttttcaat acttatctac tagttattat
     6061 ctacctctat gaaaagaact ttggaaaaac ttaggatttt ccaaataaac gtctcgttta
     6121 tgattaccac ctttcttact gtataaaggt agcatgtgtt cagtatcagt tagaccaata
     6181 tcatctacag aacctgaccc acctaaaatt ccgcttaaaa gtacttcatc tttagaaata
     6241 atgattcgtt tcatctactt ttcctcctta gttttctttc ctaatgaaat gcccaaaact
     6301 aaactgatta agatactaat cattccaatt aattgacccc agatattatc cttctcacct
     6361 gtagatggta aagactgagt agaaccattt ttaatagtgt cattttccaa tcgctttaac
     6421 ttagtaattc tattttgatt gttcttaacg gcactataag gcttgctttg cacttttact
     6481 gaatcaaatt gtttattttc tttcacactt ccgtgttttt cactaactgc tgctagaata
     6541 atattctttt tatgcgattt agctgttttc ttgaccttag tggctacgat tttaggtttt
     6601 actggcttct tcacagtttt cttcttagtt tcagctctag gagccgcata ctcttgatta
     6661 cctgtcgtaa ctttagtcag atctgcagta gagctagcaa catttgcagc attctcaaat
     6721 acgctatttt caacaaagtc agtaatagca acgtcattgc tagactgtgt ttgatcatct
     6781 tcagctacag tcacttcagg tatttcatta ctttcagatt cagtagtatt atcatccttc
     6841 ggttgatcct taattactgc ctgttccact aatttattag ctgcatcaga atacaaaaag
     6901 ttatataact cttgtcccgt cttttctcca ccgacccatg cactaataat ttttccatta
     6961 ataaatctca ttgtagttgg agtacctgga ataccaattt ctttgaaggc atactcatgt
     7021 gctccttctt cagcatcaat attgaaataa agcagcttac ctttaacgat ttcattgaaa
     7081 tcttttaaat caggtgaaaa ttgtcgacag tagtaacatg ttggacgacc gatatacata
     7141 agatgttctt gattattttt ctctgctaga agatctttta cttcttgcat ttttactcta
     7201 tgaaaatctt ttacattgtt ctcataatct tcaacagata cctcatcttc atcatcttca
     7261 ctatcttcct catttgcatt attaggatct tgattattag tattctgtga ctgattattt
     7321 tgatcttcag aagctgctgg ctcttcttcc tgcttatttt gagtttgagc tgcttcgttc
     7381 ttactactag ttttctgctc agattcggaa acatttttat catcattttc tgttttagat
     7441 actacttcac ttttattctc ttgagaagta ttaccttcat ccgcatgcac aatagtacta
     7501 ttcatcatca ataatactgc tgggctcaac attaacatta atattttttt cttattcata
     7561 gatcttcctc cgtatttttt ataactaaga aaaatatatc aattatcagc tatctttttg
     7621 gttatcagac ttattcagta cactttttga ccaaatcagt tatcaaaata attggaattt
     7681 gattctaact aaaaaagagc ttttcagctc cttttaattt tggttaagaa ttttatcctt
     7741 aaaatattca aaatatgtac tcttacctgt aataatagtt gcgttgcctt ccatcccata
     7801 tttcaaattt ttcttggact tggccttaca gattacttca tagacattat ttccgcgtag
     7861 attaatggga tatactccaa tttctttcac ttttcctact aatctatcca ttgttccact
     7921 agcattagct acctgaaaat acagtgtttg gccttttttt attgccccaa ttttattacc
     7981 tgggaaataa gtaactacat tgaccgttct tttagcctta atcatcggaa acaagtgaac
     8041 tgtattctcc tgtttatcat caagatgaac tagccatttt tctctatttc ttctaacaat
     8101 ttgtccttca tgatagtttc tattggcaat attaagtgta ttttgtggtt ctacaattcc
     8161 ggtagatgta actgtacttt gtctagttgc aaagaaagaa ccgactatta agatcagaac
     8221 taaaattgcc ataggaataa taatcatagt tgaaaaattc ttgaatttat aggaatagta
     8281 ttcggtactc tcatagtctt tattattcat aacgttgctc ctaattctca actaagttat
     8341 agtaaaagcc atgtttctgc attaatttct catgacttcc ttgctcaaca atttgaccat
     8401 gatctacaac cagaatattg ttagtccttt gtgcaattgc taaacgatga gcaataaaaa
     8461 taatagtttt atcttttaat ttcattaaat tatctactac ttttttctct gtaatcgtat
     8521 caagcccgct agtggcttca tcaaaaatta aaattttagc cggtgacaat aatgcacgtg
     8581 caatagttag cctttgcttt tgcccaccgg ataaaatctt ggcattttca tccatcttgg
     8641 tttcaaactg cagtggtaat tgttcgattt cagactcaat ttctgctatc tgacaggctt
     8701 tcaatatatc tttttctgta atatctggtc gactacctaa gagcagattt tctttgattg
     8761 ttcctgagaa gatgtatggt gtttggggaa catagtttac gtatgaccgt aagacatgct
     8821 tatctacttt agtagaatta aatccattaa aagttaactt gcctttgctt ggagagaaga
     8881 aatcaactaa aagtttgacc atagtagact tacctgagcc actcatccct acgattgcca
     8941 acttatcatt gggttcgatt tttaaattaa tatcttttaa tacatcgact ccatagccat
     9001 aatgatagtc aacatgatga tattcaatct cacctgctaa ttgcttggca tccctaatct
     9061 gagcatcttt ctggaactca ctcttaacca tgtatacttc attcaatcga ttttgtgcta
     9121 cattagctga ttgtagagtt ggttgaagat taataatgct ctgaagtgga tctacaaaat
     9181 acgatagtaa tgcgttgaag gtcattaatt gaccaatgct catctgcccg ttcattacaa
     9241 ccttagcccc tacccagagg ataattacat tgagagataa ctgaatgaag gtctttaaag
     9301 ctgactgcaa agattcagtt ttactgtaac gaaaagattt cttgaggtaa tcgacgaatt
     9361 gactatcaat cttacgataa cgtgtttgtt cgctatttaa agctttgatt gtttcaattc
     9421 cttgaatatc ttcaattact gaagaactta agacagcatt actctccatc tgatcattat
     9481 tcatcttttc aaatttctta gaaaagctaa gaatcaccac tgcataaatt ggcaaagaca
     9541 gtagagtaat cacaaataga gtggaatttt gaattgccaa aactattccc atcacaatta
     9601 caattgaaag atcaagaaat aatgaaataa ctgtactggc gagtgcgtca ataattcgac
     9661 tagcatcaga gaaccttgag gtaatttccc ctgttctacg agttacgaag aattccattg
     9721 gtaattcaaa aatatggcga atgtattgta agttaagatc aatacttaat cgctgaccta
     9781 gaacatccaa tagaaaattt tgcccgtaag aaaagataga gttgaaaaca tatgctatca
     9841 ataaaccaat agctaggatc gacaaagttt ggtatgtacc gctaggaata taagtatcaa
     9901 ttaagccttg caagaagtat gagctacaaa tactaatgat tgtcatcaaa agagcagcca
     9961 aaataatatt agtgactagt ttcttttgtt tgaacatgta tggaaatagt gaccacagat
    10021 tttgcttttt ctctttgagt ggctcaaaat catcatttgg gaccataaaa agggcaattc
    10081 ccgtccattc ttgagaaaac ttttctttag acattttcgt taaaccaacg ctaggatccg
    10141 gatcagcaat cactaaataa tttttggttg ccttaatcac aacataatag tggagtaatt
    10201 cgccttgctt taagacgtgt acgatgaaag gatattgaat gtctgcatca ggatcaaaca
    10261 aggacatgtc agctttaact gcttcagttt ttagattaaa tgcttgtgct gttttaacta
    10321 agcccagagc ggtagtccct tctaaattag tgcgggctga atgacgtaaa tgggctaaaa
    10381 atactctaga atgatatttt ttaagaatca tagctaagca tgcaactcca caatctgatt
    10441 cgtctacttg tggtacataa attgatttat actgtagtaa catcttttcc actcctcata
    10501 ttaagttgaa tccattattt catgattgga aaactaaatg taaaaaaata ccaaatcggt
    10561 tattctcatt accgattcgg tattttagtt ttctaactag attgagctac tcaactttaa
    10621 tattttcaaa tttatctaca agctttttaa ccacggcttt atacgatcta gaataagtta
    10681 ccatctgacc attatcaaat ataataatgc gttccttcgt gtcaattgca ctaatgttct
    10741 taggatttac caaagaagat tgcgaaactt ttgccaagaa tgggttttct ttatcaatct
    10801 gagtaatatt tgccttatac tcaacttctc cattctcagt aaccatatgt actttatgct
    10861 gtgtagtact gtgttcaatg aaaagtatat cgccttcggc cactttacat acgcgccgac
    10921 caatcttata agtaaagtca cgttgactaa acttaattct gttagataaa ttatcgaagg
    10981 cgttacgtaa cgtttcttcg atacgttgaa taatcttatc agacgacata gacttactaa
    11041 tataatcaat tgcaccgata cgacggcgat acgttaatgg agcgtactta tcgtacgccg
    11101 ttacgaagat gatctgggca ttttcgtcat tcttcttgat gaattcagct aaatctacgc
    11161 cattcttagc tttagactct cgacttaatt caatatctaa gaagtagata ccattcttaa
    11221 tatcatttgt gactatgtat cctaccgctt gagcaaaatc gttagcaaca aacgtaacag
    11281 attcatttaa ttcagcgtaa ccttcattat catctattaa gtcttgaata gatgcattga
    11341 tattcttagc catctgatta gctaaatctt tatcgtcatc gcatacaatg attgggaact
    11401 tactcatcct cttcaccatc ttccgtatca attgtcatat aaaagtcgaa ccagccgtct
    11461 tgaattgtat aagaaataga catatcagga tatttactct caatttcctt aatattagct
    11521 aatccaagcc ctttatggtc tttcttagta gtaaagccac gttgttgaat ttgactagtt
    11581 gagatatttt tattttggat tttatttctg atttcgaact caaattcatc tgggtcatca
    11641 gaatagacca ttatttggac ttcagcactt cgaatatcat gcttttcggc aatcaatgct
    11701 ttactttcct caattgcatt atcgaaagta atgccaataa tacgtactag atcgagttca
    11761 tctacatggt ctggtaaatt acggatatta tttcgacatt caaaattata tggtatatcc
    11821 aaattataca attctgttat ctttggaata ataatgctct taattgattt aacgtaaatg
    11881 tgatttaggt ctttatattt aagtaaggct ttagaattta ggttagtttc agtatattta
    11941 tctagtttct gaattacttc ttgaacgtta ccttcttgcg cacttacctt taaagaatta
    12001 agaatatttt tgtaatcatg tctgaaggcg cgaagatcat cttcactttt ttcaagataa
    12061 gaagcatatt cttcaagctg atgctgctgt tgctttaatt tttcttgatc ctttttattt
    12121 aaaagttttt cttgtaccat cgtcatttca tgatatataa atatagcaaa aatagtttgg
    12181 ataagaatat agagagaaaa gaacaaagtt aatggtgtaa aagatttgct ttgaatatat
    12241 atgatagaga tgctcaccgt agaaacatag gtataagcta atatgcctac gaaaatttta
    12301 ttattttggt ttgctagata attatatatt tttccattac ctagttttat tgcaactatc
    12361 atcattagta ttagtaagaa acgtagtgat aattggccta tcaaagtaaa tgacataacc
    12421 tgagtgatca tatcagacac aatatcaact aataaatcta atgtgcatac taatattatt
    12481 gaaccaaata gtatttctaa tgtattattt tttctcaaat ataatacaaa aagcaaagtt
    12541 tcaagtatat ttgtgaagat tacgccaata ttacctatag acaataacaa ccctaaaaaa
    12601 atattagcaa tacacaaaaa tagaatctgt ctctttttag atcttactct tgatatttta
    12661 aaaaaacacc atacatctgc taaactagaa aaaacattaa gaaaaagaaa taagactatc
    12721 ttttccatat attattccaa agttttttac tcaagaaatt aaaaccaaca tgtgccgtgc
    12781 ttccaccaac aaccttagtc aattcttctt ccttcaaaac agtcttttta acattttgct
    12841 tcttcatgat atttcatcct ttcatgattt tatactcaac ttgtttacac ctttaatata
    12901 tcatgtactt ttaagtaaat taaaaaagat accaattcag tcatactttc gtaccgatcc
    12961 ggtttcatat ttcttcaaac gtaaacaact gacaattaat tttcttagct aattcctgac
    13021 agctatccgt aaagccagat ttggaaaata gataataatg cttaagtgga tacttgaaga
    13081 tttcactatt tgtaatcaat ttttctaaca cactacgaga gatcggttca ttcttccatt
    13141 tacattcgcc gaaatatcca tcacgttcat cgtcagagaa tcctacaata tctaactcaa
    13201 cttgttgatg tgttctctta tcggttcccc accaattgcc caagtggata aacggattag
    13261 gaacaatttt ttcattcata tcctgagacc acatgaagtc ttgactgtat ttttcaaact
    13321 caggtcccat gaaatcagat agaccctttt gtacttttac ccaagcaaga tcagttaagc
    13381 cacgctcaat tagatcggtt tgcttgccaa caaaggtata ccagaagcgg aacatcccgt
    13441 cacagatacg ataaacgata tttttgcttt tactcttctt ttgctcagta accggtaact
    13501 ttttctcaac aatacctaaa tctatcaaat tattcaggta cgtggttagc ggaccagttt
    13561 gtaagtgggc ggattgcgca attttactat gcttagaagc acctgaagct atcgcattga
    13621 taatcgaatt atagttagtt ggatcgcgta attcctgttg taacaagtta ttaggctcat
    13681 caaataagcg acctgattta ctcaaaaagt ttttcttaat attatccgca actgacatgc
    13741 tgtctgacat ataactcaaa tattggggta caccgccaca aaccgtattg atgataaaag
    13801 cgtcctcttt actgagtttt ggtaacattt catgtgcttc tgataattta aatggttcaa
    13861 gctttaaggc taaagtgcga cgaccatata gtggactttg gtagcctaag acttgtcgtt
    13921 ccataaatga catcgatgaa ccacataaaa tcaaaaatag gttagtttct ttgaattcat
    13981 gatcaatgta ggattgcaac attgaactaa ttgtagggta agccttagcc aaataaggaa
    14041 attcgtcaat aactaaaatt acacgttgtt tttgagctag gtgtgtaatt tctttaaagc
    14101 attcctcaaa atttgcaaat ttttcttttc caccctgatc tgtattttta aaaatactaa
    14161 ttgcatcaga aaaacgtttt agattatctt ccgcattttc ttcaagtgct acataataaa
    14221 ttgacttttt atcttttaaa aactcattga tcagtgaagt ctttccaatt cttcttcgac
    14281 catagatcac tgtaaattga aaatcatttt cttgatacgc ctgattcaat tgctctaatt
    14341 cttgatgtct acctacaaac atagcgcact ccttttcact acatcgtaat atactacatt
    14401 atattatact ataacacgat atagtataac gtaatgtacg tgtattctat ttttgtaata
    14461 aaaatggccg ttacttagag aaatagcgaa gatcattaaa ttttaacatg ctataataac
    14521 aatagaacaa gaataaaaag ttttagcgtg cgcgttgagg tagctcctca acttagtcat
    14581 taacgtgtgg ctctgctttg gcaaagcttt tttgttatgt taatacccta caaaaaagac
    14641 cgtgcatccc tgcacggtct tttcatctta tcacatctat tttctaacgt attcgccgtt
    14701 cttgtactta aattcaatct tcttgttagg caattgaacc gtaattctgc gatatacagg
    14761 accgaagccg tgcttttcaa gcttaacttt cacgctaccg tccttgttta ccttaacctt
    14821 gtacaagttg tattcgccct tttggtactt aaagtcagtt ccgttatctt gatagtgaac
    14881 gtacttaccc tttttaccaa atagtctaaa ggtcatactc tcgtctggtt caccagagat
    14941 gtggctaact tctttacccc atggcaagat agtgttcttc ttgataaaca gtggcaactt
    15001 gccaattggt gcatcaacca aaatcgtggt ctttccagca tgttcaacac cattccagaa
    15061 atcaatccat tttccttttg gcaaatatac ggcacgcttg gtttgacctt cttgaacaac
    15121 tggggctgcc aaaatgtcct cgcctaccat atattcatca ttcaagttat acacctgtgg
    15181 atcattttca taattaagga caagtggacg cataattggc aaacctgtct tagtttcacg
    15241 atagaattca tcgtaaagat atggaatgaa acggtaacgc agcttcaagt acttacggta
    15301 aattgacaag gttggttcgc caaatatcca tggttcttgt gagcgagttc ctagagccgc
    15361 atggtttctg tacaatggac taaacaatgc gccttcgatc caacgagtca a
//
