LOCUS       c00014_JAKWZW0..       12266 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAKWZW010000002.1 Lactobacillus crispatus strain CM_A08_S825-bin_2
            DICIFCGM_2, whole genome shotgun sequence.
ACCESSION   JAKWZW010000002
VERSION     JAKWZW010000002
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-20 14:51:19
            Original ID  :: JAKWZW010000002.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12266
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12266
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3841:6376]"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3842..6376
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
     cand_cluster    1..12266
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Amidinotransf and OTCace and OTCace_N
                     and AA_kinase)"
                     /kind="single"
                     /product="Arginine2_Hcarbonate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12266
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Arginine2_Hcarbonate"
                     /region_number="1"
                     /rules="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /tool="gutsmash"
     CDS             137..451
                     /locus_tag="ctg14_1"
                     /transl_table=11
                     /translation="MKRCKNWVVTIVAFLMLVGEISVLPANLQGSTSVVNAAIHHRRRK
                     HQYRDKTKIYTSNYRIVDNKRSKIFHVMRGHNYRMNRENAVFFKSKAAARAAGYRESKR
                     "
     CDS             complement(492..2792)
                     /locus_tag="ctg14_2"
                     /transl_table=11
                     /translation="MSDKFHGLTQAEADKRLKEDGLNEVPEPEYNFFKEFLSKLWNLSA
                     WILEAALILECILGKWVQSLFVLLMLLFAAFNGASKKKQSRRVLNNISHKLTPTVSVER
                     DGKWIKLDSKQLVKGDLISLKRGDVLAADVKIVDGNLACDESSITGESKPVKKAIDDTA
                     FAGTTVVEGDGLAVVTATGKDSRSGKTINLINNSAAPGHLQQLLTKIIYYLCLLDGVLT
                     LVIIIASFFKGGNFNTFINMLPFLAMMFIASIPVAMPSTFALSNSFEATRLSKEGVLTS
                     DLTGIQDAANLNLLLLDKTGTITENKTAVAAWTDLSDLPDKDVLALAGAATDKRNAGII
                     DTAIDEYLVENNIPVMNAENFTPFTSDTGYSMADVAGHNAKLGSFKQLSLIDKHADEEI
                     SGINFKAGRSVAVLIDDKLAGVFILQDKVRTDSKAALAELKKRGVRPIMLTGDNQKTAA
                     AVAEQVDLTGKVISIHDFNENTDINDLAGIADVLPEDKLKMVKLFQEKGYIVGMTGDGV
                     NDAPALKQAEVGIAVSNAADVAKRSGKMVLLDDGLGSIVKILDAGHRVYQRMTTWSLTK
                     LARTAELTMLLTFGYLFFDYIPMALNAMVIYTIMNNMVTMMIGTDRTHITYKPENWNMA
                     KLAKIAFSLAAGWTLIGIGFVWFLNTHGWSHGAVSTMVYVYLVLSAMLIVLITRTRKYF
                     WQDYPSKLVGSVQIADVLLTFILALCGWAMVQISIQNLAITVIVAIIAAIIIDLIYQPV
                     MKNRYIITINFIN"
     CDS             2921..3091
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     57.3; E-value: 3.9e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg14_3"
                     /sec_met_domain="HTH_1 (E-value: 1e-18, bitscore: 57.3,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLKQLRYFLVVAEEKQITAAAKRLYIAQPPLSYQLKQLEKELGA
                     HYLKERHMVLS"
     CDS             3097..3768
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_4"
                     /sec_met_domain="LysR_substrate (E-value: 7.9e-30,
                     bitscore: 93.8, seeds: 361, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VGQIFQSYANEIISLAQNAENQVHKTISGELGTIAIGMASSSTGL
                     IPMNSFNELRKYYPEISFDIYEDNTYGILDKLEKKTIDLGIVRTPYNQTGLNTKTLTTE
                     KMMAISVDPDFQPKKELRIKDLADQPLIIYRRFEDIFNQTFAHHGLKPFYAVKCDDSRT
                     AITWAKRKMGVALVPESIATTYAQENMIAIKHANWITHLQLVWRKDHQVTPLMKKIIAA
                     I"
     CDS             3842..5071
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_5"
                     /sec_met_domain="Amidinotransf (E-value: 2.4e-109,
                     bitscore: 355.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPIHVYSEIGKLKTVMLHRPGKELENLAPDILHRMLIDDIPYL
                     KIAQEEHDAFAHVLRQQGIKVLYLEDLLAESLTDEKVRRAFLDQLLDESSIKKQDPLHQ
                     LLLNYLQELLTKEMVKTVIAGIRKSAIHNSTPSLADLAEDPDYPFYLDPMPNVYFTRDQ
                     QAAIGSGMTINRMTFRARRRESLFMETILKNHPDFKNATIPVWRDRYHHGRLEGGDELV
                     LNNHVLAVGISQRTSATAITDLAHNLFDHSSYDTILAIKIPHNHAMMHLDTVFTMINYN
                     QFTVHPFILDKAGKIDIYVLQPDDHNGVKITEKNDLVQVLKENLHLSELDLIPTGGGDP
                     IAAPREQWNDGSNTLAIAPGEVVTYDRNYVSNDLLRKHGIIVHEIRSSELSRGRGGPRC
                     MSCPLIREDL"
     CDS             5082..5513
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_6"
                     /sec_met_domain="OTCace_N (E-value: 5.2e-38, bitscore:
                     120.5, seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYLQNVFQGRSFLDCKDYTPAEISYLIDFALHLKELKKEHIPHE
                     YLKGKNIALLFEKASTRTRSAFVVACNDLGAHPEYLGASEIHLGKKESVKDTAKVLGSM
                     YDGIEYRGFAQEDVEELAKYSGVPVWKWVMAAIMLPTVF"
     CDS             5474..6376
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: AA_kinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_7"
                     /sec_met_domain="OTCace (E-value: 5.2e-47, bitscore: 149.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="AA_kinase (E-value: 2.5e-20, bitscore:
                     63.1, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VGDGRDNVADSLLVCGSMLGVNVHIVTPKPLFTHPDVQKIAQNFA
                     QDSGSKNLITDDIAQGVKGANVVYTDVWVSMGENDWSERIKLLKPYTVTMKMMQMTGTP
                     DDQLIFMHCLTAFHDRTTQVGEEIYEKYGLNEMEVTDEVFNSKYAWQFTEAENRLHSIK
                     AVMAATLGNLFIPIACGGGGILVIVKDGHLRGVAGVIHKDFSAAKMAEDINADELVILT
                     TVDHAFLNYGKENQQAIGKIKVEQLKQYLAAGYFAAGSMKPKIEAAIEFVEKTGNLAII
                     TSLSNANKLADGVGTIIYN"
     CDS             6390..6926
                     /locus_tag="ctg14_8"
                     /transl_table=11
                     /translation="MNIFNEGKKQDIAQVLAAKDRRVAVQHKIFNKYPNQTLVDINMNI
                     PGPIKNNRYLTKMFMLGINELENAWTNLGYHFKLVTQLNDDSGCENFYVLSLSIEKVKR
                     STIDFENQISLGRLFDADVLVKNKQAAISRRDLGRQPRKCFLCDRPAKECARSRRHSVE
                     QMQAFISQLYQEYVA"
     CDS             7006..8208
                     /locus_tag="ctg14_9"
                     /transl_table=11
                     /translation="MNKFIDVRIGISMELKKNKNNLKQITALIQYAFLKNNDLTKDENF
                     MSRYDHSTGYGYFDKEKLASYIMVNRFKSDVFGHHLPMAGIGYVASYPEYRGQGHISQL
                     MKEILHDLHRQDIPFANLAPFSESFYRQYGFSNSIYQKEYRFDGSALRSFKLPRSGHIV
                     RGKWDNLAVQNGVIQLYERQLHTDDERNTVVREAWWWNRLDSYYHHRNVAVYFDADERP
                     ISYLIYRIRDNTFLADEMYAITPQGLLSMFGFMGSHAGSVKQFKMSVPEKSLRAELFPE
                     QNELQVDLRPYMMSRIIDFEKVLACMRPMQEGDFNLEVNSDEQCPWNIGVWQLSNHGRK
                     VAVERKEDALVDFSGSITAWTQVLLGRLTMNAAVKLGLITDYRIKKLDFVKGDVSFYDY
                     F"
     CDS             8224..8385
                     /locus_tag="ctg14_10"
                     /transl_table=11
                     /translation="MSKEKKLNLIKLFGIVVSGLNLIFFALMALNKHEDTKDKRRVAEE
                     GHAPLDEK"
     CDS             8387..8992
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_11"
                     /sec_met_domain="LysR_substrate (E-value: 1.6e-12,
                     bitscore: 37.3, seeds: 361, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELKIAYFDQLGRKELDQAVQHFVLKHPNVDVKLLATSHDGAFA
                     KLNEDEADIAINDLRDENLNFDETELTQAGVMAILPKGMYPNGIQMIEKDELNDMTCFI
                     VAKPEEEVSELHLFKDLYQIGSQFIASNSVEEAALLVASRSGYFILNENTARLINTTDL
                     QPLFLLDHGQLIKQKIMAFYKSNSALSSEFIKLLQQEY"
     CDS             9048..9158
                     /locus_tag="ctg14_12"
                     /transl_table=11
                     /translation="MKADSYILHSGDDFYAKKNFVTFNINGTCFRINWFG"
     CDS             9124..9630
                     /locus_tag="ctg14_13"
                     /transl_table=11
                     /translation="MVLVLGLTGLASQVETVDASTYGNGVQVTIPKKMQGTWYSYDRNA
                     HNGTKITFTEHTVNGKPIFTQEASTISDYFNGRIANQKNFDKVTQNWMSGKTTKMKNDT
                     FYEIDPWITFENWSLYRVVPQTINGKKHNVLVYSSRYDGGNYFRSKKLAKKMKDYKFKK
                     VNYTL"
     CDS             9696..10388
                     /locus_tag="ctg14_14"
                     /transl_table=11
                     /translation="MTKLILGGEVMKLKQTPILRLYKLETNKEDHAKFVKAGQHNMLTS
                     QENEPGTLFMQTSHDEETTNFVVECYQDEASYDTHANSKQFKDFTDVAKDILTSRVKVE
                     LFPEFISTKAEKLAVTGSNDYVIYLTEIGVSLGKGDEFAHAVMKEMKTAVEEEKDILAM
                     IAGTVADQPNEWLAIEVYRNNEAYKQHLETKNFKEYLNNTKYCVESKSLRKLQPDVIVD
                     QGAIFYQP"
     CDS             complement(10486..10632)
                     /locus_tag="ctg14_15"
                     /transl_table=11
                     /translation="MIRSIKMKGMRTLIKLLLIGGSFLTLGLMAISSVLINKPAVAKVK
                     HRH"
     CDS             10958..11998
                     /locus_tag="ctg14_16"
                     /transl_table=11
                     /translation="MPGIVEQTLLEQQNIDLNEMVTMNQMIDQLLPNASKELQQKLKIK
                     IYNFVRTRKQPSITVRRRKYFKPAVAKLIIGNVQDYADAIERRAKEAPAKEDATDKRPA
                     SKSKRVKTITKRKILAKVIKNDKIDKSIQKKLEDKIASIVKTNFIKPVNKRGSFSVEDG
                     EKVIAELSPFYQNIKIDQKYRKNAEKAAENKETETKEKPEQHSKDQNESREGQSKDFER
                     KNNQKNSNNRNNNNQTQNQRKRQNKHPFEIRRENNNRSRNNQSNRRYNNRNNYDNRNNY
                     EFDEASGLRERYNTVIRNYNQLEQRYNALQDKYNQALDDKARLIEEMGKKNEDLRRVLI
                     DVLRKM"
ORIGIN
        1 aaaaaatcaa tttacgagaa agaactattt acacaaaaga tttgacagtt tcaaactagt
       61 ttctaataaa cgtaggaaca cttcatatat aaacgtatac tatataaata tagtgacata
      121 ttaagggagt gtttttatga aaagatgcaa gaattgggtt gtgactattg ttgcatttct
      181 gatgttagtg ggagaaatca gtgttctgcc tgcaaatttg caggggtcga catcagttgt
      241 taatgcagct attcatcaca gaaggagaaa gcatcaatat cgtgataaaa ctaagattta
      301 taccagtaat tacagaattg ttgataataa acgatcaaaa atctttcacg taatgcgcgg
      361 tcataattat cgaatgaatc gtgaaaatgc agttttcttc aagagtaaag cagcagcacg
      421 tgcagcagga tatcgtgaat caaaaagata aattaaaaga cttctaagag ttcaaagttc
      481 ctagaagtct tttaatttat aaaatttatg gtaataatat acctgttttt catcacaggt
      541 tggtaaatta agtcgattat tatggcagca ataatcgcta caattacagt aattgctaag
      601 ttttgaatgg aaatctggac cattgcccaa ccacaaagag ctaagataaa ggtcaataga
      661 acatctgcaa tttgaacact accaaccaac ttggatgggt aatcttgcca aaagtactta
      721 cgagttctag taatcaaaac aatcaacatt gcgctaagaa ctaggtatac gtaaaccata
      781 gtagaaacag caccgtgact ccaaccgtgt gtgtttaaga accaaacaaa cccaatacca
      841 attaaagtcc aaccagcagc tagtgaaaag gcgatcttag caagcttagc catattccag
      901 ttttctggct tataagtaat gtgagtcctg tcagttccaa tcatcatcgt aaccatattg
      961 ttcataatgg tatagataac cattgcattc aaggccattg ggatgtagtc aaagaaaaga
     1021 tagccaaaag ttaacagcat cgttaattca gcagttctag caagcttggt tagtgaccaa
     1081 gtagtcattc tttggtatac gcgatgtcca gcgtctaaaa ttttaacaat tgagcctaga
     1141 ccatcgtcta gtaataccat tttacccgaa cgcttagcta cgtcagcagc atttgaaact
     1201 gcgattccta cttcagcttg ttttaatgca ggcgcgtcgt taactccgtc acctgtcatc
     1261 cctacgatat agcctttttc ttggaaaagc tttaccatct tgagtttatc ttctggtaaa
     1321 acatcagcaa taccggccaa atcattaata tcagtatttt cattgaaatc gtgaatcgaa
     1381 attactttac cagttaaatc aacttgttct gccactgcag cagcggtctt ttgattgtca
     1441 ccagttaaca taattgggcg aacgccacgt ttcttgagtt cagccaaagc tgctttagag
     1501 tctgttctaa ctttatcttg taagatgaag acaccagcta acttatcgtc aatcaagact
     1561 gccactgagc gtcctgcctt gaaattaatt ccagaaattt cttcatcggc atgtttatcg
     1621 atcaaagata attgcttaaa tgaaccaagc tttgcattat gtccagcaac atcagccata
     1681 gaataaccag tgtcagaagt aaatggagta aagttttcag cattcatgac tggaatgtta
     1741 ttttctacta agtattcatc gattgctgta tcgataatac cagcattacg tttatcagtt
     1801 gcggctccag ctaaagcaag cacgtctttg tcaggcaagt cacttagatc agtccaagcg
     1861 gctacggcag ttttgttttc cgtaattgtt ccagtcttat caagtaaaag caagttcaag
     1921 ttagctgcgt cctgaattcc agttaggtca gaagtcagga ctccttcttt acttaagcgg
     1981 gttgcttcaa atgagttgga taaagcaaaa gttgatggca ttgctacagg aattgaagca
     2041 ataaacatca ttgccaggaa tggcaacata ttaataaagg tattgaaatt accgcctttg
     2101 aagaaggagg cgataataat aactaaggtt aaaacaccat ctagtaagca aaggtagtag
     2161 ataatcttag tcaaaagttg ttgtaagtga ccaggagcag cggaattgtt gatcaaatta
     2221 atcgtcttac cgcttctaga atctttacct gtagcagtaa caacagctag gccatcacct
     2281 tcaacaactg tagtaccggc aaaggcggtg tcatcaattg ctttcttaac tggtttagat
     2341 tcacctgtaa ttgagctttc atcacaagct aagttaccgt caacaatttt aacatctgct
     2401 gcgagtacgt ccccgcgttt aagtgagatt aaatcgcctt taactagttg tttagaatca
     2461 agtttgatcc acttgccatc gcgttcaact gatacagtag gagtcaactt gtgtgaaata
     2521 ttatttaaaa ctcgtcttga ttgctttttc ttagatgcac cgttaaatgc agcaaataaa
     2581 agcatcaaca acacgaataa tgattggacc catttgccca agatacattc tagaattaaa
     2641 gcagcttcta gaatccaagc ggataggttc cataacttag acaagaactc tttaaagaaa
     2701 ttgtattcag gctctggtac ttcatttaag ccatcttctt ttaagcgctt gtctgcttcg
     2761 gcttgagtta agccgtgaaa tttatcagac attattttcc ctccaaatct accttaataa
     2821 ggtagcacag atattgctat gaataaaata ctaaaataca atataagata ttaaatattt
     2881 taatatcact atcaattgaa ataaaaaaag gataaataat atgaatctaa aacagttacg
     2941 ttattttcta gttgtagcag aagaaaagca gattacagca gctgctaagc gcttgtatat
     3001 tgcacagcca ccattaagct atcaattaaa acaattagag aaagagttgg gcgcgcatta
     3061 tttaaaagaa cggcacatgg tattgagcta actgatgtgg gacaaatttt tcaaagctat
     3121 gccaatgaaa ttatttctct agctcaaaat gctgaaaacc aagtacataa gactatttcc
     3181 ggtgaattgg gaacgattgc aattggaatg gcatcttcct caacgggctt gataccaatg
     3241 aattctttta atgaattacg aaaatattat ccggaaattt cttttgatat ttatgaagat
     3301 aatacttatg gcatcctgga taaattagaa aaaaagacaa tcgatctagg cattgtacga
     3361 acgccttaca accagacagg tttaaatact aagactttaa caactgaaaa aatgatggct
     3421 attagtgtag acccagattt tcagccaaaa aaagaattac gcattaaaga tctagcagat
     3481 cagccattga ttatttatcg tcgctttgag gatattttta atcaaacttt tgcacatcat
     3541 gggcttaaac cattttatgc ggttaagtgt gatgattcac ggacagcaat tacttgggcc
     3601 aagagaaaaa tgggagtagc gctagtacca gaatcaattg cgacaactta tgcccaagaa
     3661 aatatgatcg caattaaaca tgctaattgg ataacacatt tgcagctggt ttggcgtaaa
     3721 gatcatcaag ttacaccttt aatgaaaaaa atcattgctg caatatgata atactgtaac
     3781 ttttacctaa ttgatccata ataaatgtaa acgggtacaa taattaatag aaggtggttg
     3841 aatgtcgagt ccgattcatg tttattcaga aattggtaag ttaaaaacgg tgatgttaca
     3901 tcgaccggga aaagaactag aaaatctagc cccagatatt ttgcatcgaa tgttgattga
     3961 cgatattcct tatctgaaga ttgcccaaga agaacatgat gcttttgcgc atgtattgag
     4021 gcagcagggg atcaaagtat tatatcttga ggatttatta gcagaatctt taacagatga
     4081 gaaagttcgt cgggcattct tagatcagtt actggatgaa tcaagtatta aaaaacagga
     4141 tcctttgcat caattattgc tgaactatct ccaagaattg ctaactaagg aaatggtaaa
     4201 aacggtgatt gctggaatta gaaaaagtgc gattcataat tctaccccat ctttagcaga
     4261 tttggctgag gacccagatt acccttttta tcttgatcca atgccaaatg tatattttac
     4321 tcgagatcaa caggctgcaa ttggttcagg gatgaccatt aaccggatga ctttcagagc
     4381 tagacgacgt gaatcattat ttatggaaac aattttgaaa aatcatcctg atttcaagaa
     4441 cgcaactatt ccagtttggc gtgaccgtta tcatcatggt cgccttgagg gcggggatga
     4501 actagttcta aataaccatg tgttagctgt aggtatttca caacgcactt ctgcaactgc
     4561 aattactgac ttagctcata atttatttga tcattcaagt tatgatacga ttttagcgat
     4621 taagattccg cacaatcatg ctatgatgca ccttgataca gtttttacaa tgattaatta
     4681 taatcaattt acggttcatc cctttatttt agataaagcc ggcaaaattg atatttatgt
     4741 tctacagccc gatgatcaca acggtgtaaa aatcacagaa aagaatgatt tggtgcaggt
     4801 tttgaaagaa aacttacatt taagcgaatt ggatttaatt ccaactggtg gtggtgatcc
     4861 aattgccgca ccacgtgaac aatggaatga cggctcaaat accttggcaa ttgcaccagg
     4921 tgaagtcgtt acttatgatc gtaattatgt atccaatgat ttgctaagaa aacatggcat
     4981 catcgttcat gagattcggt ctagtgaact ctcacgtggt cgtggcggtc ctagatgtat
     5041 gtcgtgtccg ttgattcgtg aagatttata agaggcaaaa aatgaaatat ttacaaaatg
     5101 tttttcaagg tagaagtttt ctcgattgta aagactatac tccagctgaa atttcatatt
     5161 taattgattt tgcattacat ttaaaagaac ttaaaaaaga gcatatccca catgaatatc
     5221 tgaaaggtaa aaatattgca ctactttttg aaaaagcctc aactaggacg cgatctgctt
     5281 ttgtagtagc ttgtaatgat ttaggtgctc atccagaata tctaggcgca agcgagatcc
     5341 acttaggtaa aaaagaaagc gtcaaggata cggctaaagt cctaggctca atgtatgatg
     5401 gaattgaata tcgcggtttt gctcaagaag atgtagaaga gctggctaaa tattctggcg
     5461 ttcctgtttg gaagtgggtg atggccgcga taatgttgcc gacagtcttt tagtttgtgg
     5521 ctcaatgtta ggtgttaatg tacatattgt tacacccaag cctttgttta cacatcctga
     5581 tgtacaaaaa attgctcaaa attttgccca agattcaggt tcaaaaaatt tgatcacaga
     5641 tgatattgct caaggcgtta aaggagccaa tgttgtttat accgatgttt gggtttcgat
     5701 gggtgaaaat gattggtctg aacgaattaa attattaaag ccatatacgg tcacaatgaa
     5761 aatgatgcaa atgactggta caccagatga ccaattgatc tttatgcatt gtttgacagc
     5821 ttttcatgat cgaacaactc aggtgggaga agaaatctat gaaaaatatg gcttaaatga
     5881 gatggaagta actgatgagg tctttaattc aaagtatgct tggcaattta cagaagctga
     5941 aaatcgattg cattcaatta aagcagtgat ggcggctact ttaggaaatt tatttattcc
     6001 gattgcctgt ggcggtggtg gcatccttgt tattgtgaaa gatgggcatc tcagaggtgt
     6061 tgccggcgta attcataaag atttttccgc tgctaaaatg gcagaagata tcaacgctga
     6121 tgaattagta attctaacaa cggtggatca tgcatttttg aattatggca aagaaaatca
     6181 acaagcaatt ggtaaaataa aagttgaaca gctcaaacaa tatctagcag caggttattt
     6241 cgcagctggg agtatgaagc ctaagataga agctgcaatt gaatttgtag aaaaaacagg
     6301 taatttagca attatcacct ctttgagcaa tgccaacaaa ctagcagacg gagtcggcac
     6361 aatcatttat aattaactgg gtgataaaaa tgaatatttt taatgaagga aaaaagcagg
     6421 atattgccca agttttagca gctaaagata ggcgagtagc tgtacaacat aagattttta
     6481 ataagtatcc taatcaaact ctagtcgaca ttaatatgaa tatcccagga ccaatcaaga
     6541 ataatcgcta tttaactaaa atgtttatgt tgggtatcaa tgagctggaa aatgcttgga
     6601 ctaacctagg ttatcatttt aaattggtga cacagcttaa tgatgatagt ggctgtgaaa
     6661 acttttatgt attatctttg tcaattgaaa aagtaaagcg ctcaacaatt gattttgaga
     6721 atcagatatc attgggacgt ctctttgatg cagacgtgtt ggtaaaaaat aaacaagctg
     6781 caatttcacg cagagatttg ggcaggcagc cacgtaagtg ctttttatgt gatcgccctg
     6841 ctaaagaatg tgctcgcagc cggagacatt cagtggaaca gatgcaggca tttatctctc
     6901 agctttatca agaatacgtt gcgtaaaata aaccgggatt ttatgattcc ggtttatttt
     6961 tatgaaaaat ctagttaaaa atttaaaaaa tgaactaaaa tagtaatgaa taaatttata
     7021 gatgtacgta taggaataag catggaatta aagaaaaata agaataattt aaagcaaatt
     7081 acggcattaa ttcaatatgc atttttgaaa aataatgatt tgactaaaga cgaaaatttt
     7141 atgagtcgtt atgatcatag tacaggttat ggctattttg ataaggaaaa attagctagc
     7201 tatattatgg ttaatcgatt taaaagtgat gtttttgggc atcatttacc gatggctgga
     7261 ataggttatg tagcttcata tcctgagtat cgtggccaag gtcatatttc ccaattaatg
     7321 aaagaaattt tgcatgactt acataggcaa gatattccgt ttgctaacct ggcaccattt
     7381 tcggagagct tttatcgcca gtacgggttt agcaatagta tttatcaaaa agaatatcgc
     7441 tttgatggaa gcgcattgcg tagttttaaa ttaccacgtt ctggtcatat agtgcgtggc
     7501 aagtgggaca atttagctgt tcaaaatggt gtgattcaac tttatgaacg tcaactgcat
     7561 actgatgatg aacgtaacac ggttgtacgt gaggcatggt ggtggaatag acttgattct
     7621 tattatcatc accgcaatgt agccgtttat tttgacgcgg atgagcggcc aattagttac
     7681 ttgatttatc gcattagaga caatactttt ttagctgatg aaatgtacgc aattacgccg
     7741 cagggattac tgagtatgtt tggttttatg ggttcgcacg cgggcagtgt taagcaattt
     7801 aaaatgagcg taccagagaa atcgttacga gctgaacttt ttcctgaaca aaacgaactc
     7861 caagttgatt tgcgtcctta tatgatgagt cgaattattg attttgaaaa agttttggct
     7921 tgtatgcggc caatgcaaga aggtgatttt aatctggaag tcaatagcga tgaacagtgt
     7981 ccttggaata ttggagtttg gcaattaagt aatcatggac gtaaggtagc ggtagaacgt
     8041 aaggaagatg cattggttga tttttcggga tcaattaccg cgtggaccca ggtgctatta
     8101 ggtagactaa ccatgaatgc tgctgttaaa ctaggattaa ttacagatta ccgcatcaaa
     8161 aaattagatt tcgttaaagg cgatgtatca ttttatgatt atttttagtt gtgaggttaa
     8221 aaaatgagta aagaaaagaa actcaattta ataaaattat ttggcattgt agttagtggt
     8281 ttgaatttga tcttttttgc cttgatggca cttaataagc atgaagatac taaggataaa
     8341 agaagagtag cagaagaagg acacgcaccg ctggatgaaa aataaaatga cggaattaaa
     8401 gattgcatat tttgaccaat taggtcgtaa ggaattagat caggcagtgc agcattttgt
     8461 gttaaaacat cctaatgtag atgtaaaact acttgcgact agtcatgatg gtgcttttgc
     8521 aaaactgaat gaagatgaag cagacatagc aatcaatgat ttgcgtgacg agaatcttaa
     8581 ctttgatgaa acagaattga ctcaagctgg tgtaatggca attttgccca agggaatgta
     8641 tcctaatggc attcaaatga ttgaaaaaga cgagctcaat gatatgactt gttttattgt
     8701 ggctaaacct gaagaagagg ttagtgagct acatttattt aaagatttgt atcaaattgg
     8761 cagtcaattc atcgcttcta actcggtcga agaagcagca ctgttggtcg cctctaggtc
     8821 tggctatttt attttaaatg agaatacggc taggttaatt aatactacag atttgcagcc
     8881 acttttcttg cttgatcatg gtcagttaat aaagcaaaag ataatggctt tttataagtc
     8941 aaattcagcg ttaagtagtg agtttataaa gctattgcag caagaatatt aatctgtaaa
     9001 gttaaaaata tcttgtctaa gtactataag atactgtaaa atatattatg aaagcggact
     9061 catatatttt acattctgga gatgattttt atgctaaaaa gaactttgtt acctttaaca
     9121 tcaatggtac ttgttttagg attaactggt ttggctagtc aagttgagac tgttgatgct
     9181 tcaacttatg gtaatggtgt acaggttact attccaaaaa agatgcaggg tacttggtac
     9241 tcttatgatc gtaatgcaca taatggcaca aagatcacct ttactgaaca tactgttaat
     9301 ggcaaaccaa tatttaccca ggaggcttcg acaattagtg attacttcaa tggtagaatt
     9361 gctaaccaga agaactttga taaggtaacg caaaactgga tgtctggtaa aactaccaaa
     9421 atgaagaatg atacattcta tgagattgat ccgtggatta cttttgaaaa ttggagtctt
     9481 tatcgagtgg taccacaaac cattaatggt aaaaagcata acgtgctggt ttattctagt
     9541 agatatgatg gtggtaacta cttcagaagc aagaaattag ctaaaaaaat gaaggactac
     9601 aagtttaaga aagttaatta cacgttatag ttttgtgaca tcccttaact aagggatgtt
     9661 ttttactaat agacgcgata aaatttagta taataatgac aaaattaatt cttggaggag
     9721 aagttatgaa attaaaacaa acaccaattt tgcgtttata taaactagaa actaataaag
     9781 aggatcatgc aaagttcgtt aaggcagggc aacataatat gcttacttct caagagaacg
     9841 aaccaggcac attgtttatg cagacaagtc atgacgaaga aactactaat tttgtagtag
     9901 aatgctatca agacgaagca agttatgata ctcatgctaa ttcaaagcaa tttaaggatt
     9961 ttactgacgt tgctaaagat attttaacta gtcgagtaaa ggtagaattg tttccggaat
    10021 ttatttctac aaaggcagaa aaactagcag ttaccggatc aaatgattat gttatttatc
    10081 tgactgaaat tggtgtttct ttaggtaagg gcgatgagtt tgctcatgct gtaatgaaag
    10141 aaatgaaaac ggcagtcgaa gaagaaaaag atattttggc aatgattgca ggaactgttg
    10201 ccgatcaacc aaatgaatgg ttagctattg aagtttatcg taataatgaa gcttacaagc
    10261 agcacttgga aactaagaac ttcaaagagt atttgaataa tacaaaatat tgtgttgaaa
    10321 gtaagagttt acgtaagttg caaccagatg taattgttga ccaaggtgca attttctacc
    10381 aaccataaag aataagacga aaagaagacc aggctatgtg gagtacataa cctggtcttt
    10441 ctagttagag gggaaaagat ttattaacat atattattct ggtttttagt ggcgatgttt
    10501 tacctttgct actgctggtt tattaattaa tactgagctg atggccatta aaccaagcgt
    10561 taaaaatgat ccaccaatta agagtagttt aatcaaggtt ctcattcctt tcatcttaat
    10621 tgatcttatc atagcgaaat aatattaaga atttatatgt aaaacctaat ggattagtta
    10681 agaaaataaa actagaaaaa aggctggtta gcacgtaaaa tagaaataga gtcaaagtct
    10741 agtgcaactg cgcataaaat aaagcagtat cgatgggatg ctgcttgttt tggttaaaaa
    10801 atagagaata tgcttgtagc ccttttcgta aatagcgtta atgttgtaaa atggaaagtg
    10861 cattaagttt attaatgaga aaattgatgt attattgcaa aataggccgt aatggccctt
    10921 tttgttgtga aaaaattaaa agaatatagg attggaaatg ccaggaatag tagagcaaac
    10981 attattagaa caacaaaata ttgatttaaa tgaaatggta acaatgaatc aaatgattga
    11041 tcaattgttg cctaatgcaa gtaaagaatt acaacaaaaa ctaaagatta aaatttataa
    11101 ctttgtgcgt acacgtaaac aaccaagtat tactgtgcga agaagaaaat attttaagcc
    11161 ggctgttgct aaattaatta ttggtaatgt acaagattac gcagatgcaa ttgaacgtcg
    11221 tgctaaggaa gccccagcta aagaggatgc tactgataag aggccagctt ctaaatctaa
    11281 gcgggttaag acaattacta agcgtaagat tttagctaaa gttataaaga atgataagat
    11341 tgataaatct attcaaaaga aattagagga taagattgct tcaattgtga agaccaactt
    11401 tattaagcca gttaacaagc ggggaagttt ttcggttgaa gatggtgaaa aagttatagc
    11461 tgaacttagt cctttttatc aaaatatcaa gattgatcaa aagtatcgca agaatgctga
    11521 aaaagcggct gaaaataagg aaacagaaac taaagaaaag cctgagcaac attctaagga
    11581 tcagaatgaa agtcgtgaag gtcaatctaa ggactttgag cgtaagaata atcagaagaa
    11641 tagcaataat cgaaataata ataatcaaac gcaaaatcaa cgtaagcgac aaaataagca
    11701 tccttttgag atcagaagag aaaataataa ccgctcacgt aataatcagt ctaaccgccg
    11761 ctataataat cgaaataatt atgataatcg gaataattat gaatttgatg aagctagcgg
    11821 tttgcgtgaa cgctacaata cagtaatcag aaattacaat caactggagc aaagatataa
    11881 tgctttgcaa gataaatata atcaggcttt agatgataaa gctagattga tcgaagaaat
    11941 gggtaagaag aacgaagact tacgtcgtgt attgatcgac gttttgcgaa aaatgtagtt
    12001 tttggtaaac aaagagacta gtagtcaatt tgaattgatt actagtctta ttttatgttt
    12061 atgaaatatg atttagctta aaaattaaaa aaatatgtgt aaaaaattat tttcgtgtag
    12121 taagattaaa ggatgataaa tatttttatt aatgattaat ggaggagaag tatgagttta
    12181 aaagagctat ttaaaagcaa tgtgtttcga ggaaactgtc aaatcttttg tgtaaataga
    12241 tttttctcgt agattgattt tttaat
//
