LOCUS       c00121_JAKWYV0..       12267 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAKWYV010000009.1 Lactobacillus crispatus strain
            F4_1630_1235_1_MRS7_S268-bin_1-SPLIT FOBIPIPL_9, whole genome
            shotgun sequence.
ACCESSION   JAKWYV010000009
VERSION     JAKWYV010000009
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-20 16:19:31
            Original ID  :: JAKWYV010000009.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12267
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12267
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5890:8425]"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5891..8425
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
     cand_cluster    1..12267
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Amidinotransf and OTCace and OTCace_N
                     and AA_kinase)"
                     /kind="single"
                     /product="Arginine2_Hcarbonate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12267
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Arginine2_Hcarbonate"
                     /region_number="1"
                     /rules="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /tool="gutsmash"
     CDS             complement(269..1309)
                     /locus_tag="ctg121_1"
                     /transl_table=11
                     /translation="MPGIVEQTLLEQQNIDLNEMVTMNQMIDQLLPNASKELQQKLKIK
                     IYNFVRTRKQPSITVRRRKYFKPAVAKLIIGNVQDYADAIERRAKEAPAKEDATDKRPA
                     SKSKRVKTITKRKILAKVIKNDKIDKSIQKKLEDKIASIVKTNFIKPVNKRGSFSVEDG
                     EKVIAELSPFYQNIKIDQKYRKNAEKAAENKETETKEKPEQHSKDQNESREGQSKDFER
                     KNNQKNSNNRNNNNQTQNQRKRQNKHPFEIRRENNNRSRNNQSNRRYNNRNNYDNRNNY
                     EFDEASGLRERYNTVIRNYNQLEQRYNALQDKYNQALDDKARLIEEMGKKNEDLRRVLI
                     DVLRKM"
     CDS             complement(1879..2571)
                     /locus_tag="ctg121_2"
                     /transl_table=11
                     /translation="MTKLILGGEVMKLKQTPILRLYKLETNKEDHAKFVKAGQHNMLTS
                     QENEPGTLFMQTSHDEETTNFVVECYQDEASYDTHANSKQFKDFTDVAKDILTSRVKVE
                     LFPEFISTKAEKLAVTGSNDYVIYLTEIGVSLGKGDEFAHAVMKEMKTAVEEEKDILAM
                     IAGTVADQPNEWLAIEVYRNNEAYKQHLETKNFKEYLNNTKYCVESKSLRKLQPDVIVD
                     QGAIFYQP"
     CDS             complement(2637..3143)
                     /locus_tag="ctg121_3"
                     /transl_table=11
                     /translation="MVLVLGLTGLASQVETVDASTYGNGVQVTIPKKMQGTWYSYDRNA
                     HNGTKITFTEHTVNGKPIFTQEASTISDYFNGRIANQKNFDKVTQNWMSGKTTKMKNDT
                     FYEIDPWITFENWSLYRVVPQTINGKKHNVLVYSSRYDGGNYFRSKKLAKKMKDYKFKK
                     VNYTL"
     CDS             complement(3109..3219)
                     /locus_tag="ctg121_4"
                     /transl_table=11
                     /translation="MKADSYILHSGDDFYAKKNFVTFNINGTCFRINWFG"
     CDS             complement(3275..3880)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg121_5"
                     /sec_met_domain="LysR_substrate (E-value: 1.4e-12,
                     bitscore: 37.3, seeds: 361, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELKIAYFDQLGRKELDQAVQHFVLKHPNVDVKLLATSHDGAFA
                     KLNEDEADIAINDLRDENLNFDETELTQAGVMAILPKGMYPNGIQMIEKDELNDMTCFI
                     VAKPEEEVSELHLFKDLYQIGSQFIASNSVEEAALLVASRSGYFILNENTARLINTTDL
                     QPLFLLDHGQLIKQKIMAFYKSNSALSSEFIKLLQQEY"
     CDS             complement(3882..4043)
                     /locus_tag="ctg121_6"
                     /transl_table=11
                     /translation="MSKEKKLNLIKLFGIVVSGLNLIFFALMALNKHEDTKDKRRVAEE
                     GHAPLDEK"
     CDS             complement(4059..5261)
                     /locus_tag="ctg121_7"
                     /transl_table=11
                     /translation="MNKFIDVRIGISMELKKNKNNLKQITALIQYAFLKNNDLTKDENF
                     MSRYDHSTGYGYFDKEKLASYIMVNRFKSDVFGHHLPMAGIGYVASYPEYRGQGHISQL
                     MKEILHDLHRQDIPFANLAPFSESFYRQYGFSNSIYQKEYRFDGSALRSFKLPRSGHIV
                     RGKWDNLAVQNGVIQLYERQLHTDDERNTVVREAWWWNRLDSYYHHRNVAVYFDADERP
                     ISYLIYRIRDNTFLADEMYAITPQGLLSMFGFMGSHAGSVKQFKMSVPEKSLRAELFPE
                     QNELQVDLRPYMMSRIIDFEKVLACMRPMQEGDFNLEVNSDEQCPWNIGVWQLSNHGRK
                     VAVERKEDALVDFSGSITAWTQVLLGRLTMNAAVKLGLITDYRIKKLDFVKGDVSFYDY
                     F"
     CDS             complement(5341..5877)
                     /locus_tag="ctg121_8"
                     /transl_table=11
                     /translation="MNIFNEGKKQDIAQVLAAKDRRVAVQHKIFNKYPNQTLVDINMNI
                     PGPIKNNRYLTKMFMLGINELENAWTNLGYHFKLVTQLNDDSGCENFYVLSLSIEKVKR
                     STIDFENQISLGRLFDADVLVKNKQAAISRRDLGRQPRKCFLCDRPAKECARSRRHSVE
                     QMQAFISQLYQEYVA"
     CDS             complement(5891..6793)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: AA_kinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg121_9"
                     /sec_met_domain="OTCace (E-value: 4.6e-47, bitscore: 149.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="AA_kinase (E-value: 2.2e-20, bitscore:
                     63.1, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VGDGRDNVADSLLVCGSMLGVNVHIVTPKPLFTHPDVQKIAQNFA
                     QDSGSKNLITDDIAQGVKGANVVYTDVWVSMGENDWSERIKLLKPYTVTMKMMQMTGTP
                     DDQLIFMHCLTAFHDRTTQVGEEIYEKYGLNEMEVTDEVFNSKYAWQFTEAENRLHSIK
                     AVMAATLGNLFIPIACGGGGILVIVKDGHLRGVAGVIHKDFSAAKMAEDINADELVILT
                     TVDHAFLNYGKENQQAIGKIKVEQLKQYLAAGYFAAGSMKPKIEAAIEFVEKTGNLAII
                     TSLSNANKLADGVGTIIYN"
     CDS             complement(6754..7185)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg121_10"
                     /sec_met_domain="OTCace_N (E-value: 4.6e-38, bitscore:
                     120.5, seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYLQNVFQGRSFLDCKDYTPAEISYLIDFALHLKELKKEHIPHE
                     YLKGKNIALLFEKASTRTRSAFVVACNDLGAHPEYLGASEIHLGKKESVKDTAKVLGSM
                     YDGIEYRGFAQEDVEELAKYSGVPVWKWVMAAIMLPTVF"
     CDS             complement(7196..8425)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg121_11"
                     /sec_met_domain="Amidinotransf (E-value: 2.1e-109,
                     bitscore: 355.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPIHVYSEIGKLKTVMLHRPGKELENLAPDILHRMLIDDIPYL
                     KIAQEEHDAFAHVLRQQGIKVLYLEDLLAESLTDEKVRRAFLDQLLDESSIKKQDPLHQ
                     LLLNYLQELLTKEMVKTVIAGIRKSAIHNSTPSLADLAEDPDYPFYLDPMPNVYFTRDQ
                     QAAIGSGMTINRMTFRARRRESLFMETILKNHPDFKNATIPVWRDRYHHGRLEGGDELV
                     LNNHVLAVGISQRTSATAITDLAHNLFDHSSYDTILAIKIPHNHAMMHLDTVFTMINYN
                     QFTVHPFILDKAGKIDIYVLQPDDHNGVKITEKNDLVQVLKENLHLSELDLIPTGGGDP
                     IAAPREQWNDGSNTLAIAPGEVVTYDRNYVSNDLLRKHGIIVHEIRSSELSRGRGGPRC
                     MSCPLIREDL"
     CDS             complement(8499..9347)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     75.6; E-value: 7.6e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg121_12"
                     /sec_met_domain="LysR_substrate (E-value: 3.7e-30,
                     bitscore: 94.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.7e-24, bitscore: 75.6,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLKQLRYFLVVAEEKQITAAAKRLYIAQPPLSYQLKQLEKELGA
                     QLFKRTAHGIELTDVGQIFQSYANEIISLAQNAENQVHKTISGELGTIAIGMASSSTGL
                     IPMNSFNELRKYYPEISFDIYEDNTYGILDKLEKKTIDLGIVRTPYNQTGLNTKTLTTE
                     KMMAISVDPDFQQKKELRIKDLADQPLIIYRRFEDIFNQTFAHHGLKPFYAVKCDDSRT
                     AITWAKRKMGVALVPESIATTYAQENMIAIKHANWITHLQLVWRKDHQVTPLMKKIIAA
                     I"
     CDS             9476..11749
                     /locus_tag="ctg121_13"
                     /transl_table=11
                     /translation="MSDKFHGLTQAEADKRLKEDGLNEVPEPEYNFFKEFLSKLWNLSA
                     WILEAALILECILGKWVQSLFVLLMLLFAAFNGASKKKQSRRVLNNISHKLTPTVSVER
                     DGKWIKLDSKQLVKGDLISLKRGDVLAADVKIVDGNLACDESSITGESKPVKKAIDDTA
                     FAGTTVVEGDGLAVVTATGKDSRSGKTINLINNSAAPGHLQQLLTKIIYYLCLLDGVLT
                     LVIIIASFFKGGNFNTFINMLPFLAMMFIASIPVAMPSTFALSNSFEATRLSKEGVLTS
                     DLTGIQDAANLNLLLLDKTGTITENKTAVAAWTDLSDLPDKDVLALAGAATDKRNAGII
                     DTAIDEYLVENNIPVMNAENFTPFTSDTGYSMADVAGHNVKLGSFKQLSLIDKHADEEI
                     SGINFKAGRSVAVLIDDKLAGVFILQDKVRTDSKAALAELKKRGVRPIMLTGDNQKTAA
                     AVAEQVDLTGKVISIHDFNENTDINDLAGIADVLPEDKLKMVKLFQEKGYIVGMTGDGV
                     NDAPALKQAEVGIAVSNAADVAKRSGKMVLLDDGLGSIVKILDAGHRVYQRMTTWSLTK
                     LARTAELTMLLTFGYLFFDYIPMALNAMVIYTIMNNMVTMMIGTDRTHITYKPENWNMA
                     KLAKIAFSLAAGWTLIGIGFVWFLNTHGWSHGAVSTMVYVYLVLSAMLIVLITRTRKYF
                     WQDYPSKLVGSVQIADVLLTFILALCGWAMVQISIQNLAITVIVAIIAAIIIDLIYQPV
                     MKNR"
     CDS             complement(11817..12131)
                     /locus_tag="ctg121_14"
                     /transl_table=11
                     /translation="MKRCKNWVVTIVAFLMLVGEISVLPANLQGSTSVVNAAIHHRRRK
                     HQYRDKTKIYTSNYRIVDNKRSKIFHVMRGHNYRMNRENAVFFKSKAAARAAGYRESKR
                     "
ORIGIN
        1 attaaaaaat caatctacga gaaaaatcta tttacacaaa agatttgaca gtttcctcga
       61 aacacattgc ttttaaatag ctcttttaaa ctcatacttc tcctccatta atcattaata
      121 aaaatattta tcatccttta atcttactac acaaaaataa ttttttacac atattttttt
      181 aatttttaag ctaaatcata tttcataaac ataaaataag actagtaatc aattcaaatt
      241 gactactagt ctctttgttt accaaaaact acatttttcg caaaacgtcg atcaatacac
      301 gacgtaagtc ttcgttcttc ttacccattt cttcgatcaa tctagcttta tcatctaaag
      361 cctgattata tttatcttgc aaagcattat atctttgctc cagttgattg taatttctga
      421 ttactgtatt gtagcgttca cgcaaaccgc tagcttcatc aaattcataa ttattccgat
      481 tatcataatt atttcgatta ttatagcggc ggttagactg attattacgt gagcggttat
      541 tattttctct tctgatctca aaaggatgct tattttgtcg cttacgttga ttttgcgttt
      601 gattattatt atttcgatta ttgctattct tctgattatt cttacgctca aagtccttag
      661 attgaccttc acgactttca ttctgatcct tagaatgttg ctcaggcttt tctttagttt
      721 ctgtttcctt attttcagcc gctttttcag cattcttgcg atacttttga tcaatcttga
      781 tattttgata aaaaggacta agttcagcta taactttttc accatcttca accgaaaaac
      841 ttccccgctt gttaactggc ttaataaagt tggtcttcac aattgaagca atcttatcct
      901 ctaatttctt ttgaatagat ttatcaatct tatcattctt tataacttta gctaaaatct
      961 tacgcttagt aattgtctta acccgcttag atttagaagc tggcctctta tcagtagcat
     1021 cctctttagc tggggcttcc ttagcacgac gttcaattgc atctgcgtaa tcttgtacat
     1081 taccaataat taatttagca acagccggct taaaatattt tcttcttcgc acagtaatac
     1141 ttggttgttt acgtgtacgc acaaagttat aaattttaat ctttagtttt tgttgtaatt
     1201 ctttacttgc attaggcaac aattgatcaa tcatttgatt cattgttacc atttcattta
     1261 aatcaatatt ttgttgttct aataatgttt gctctactat tcctggcatt tccaatccta
     1321 tattctttta attttttcac aacaaaaagg gccattacgg cctattttgc aataatacat
     1381 caattttctc attaataaac ttaatgcact ttccatttta caacattaac gctatttacg
     1441 aaaagggcta caagcatatt ctctattttt taaccaaaac aagcagcatc ccatcgatac
     1501 tgctttattt tatgcgcagt tgcactagac tttgactcta tttctatttt acgtgctaac
     1561 cagccttttt tctagtttta ttttcttaac taatccatta ggttttacat ataaattctt
     1621 aatattattt cgctattata agatcaatta agatgaaagg aatgagaacc ttgattaaac
     1681 tactcttaat tggttgatca tttttaacgc ttggtttaat ggccatcagc tcagtattaa
     1741 ttaataaacc agcagtagca aaggtaaaac atcgccacta aaaaccagaa taatatatgt
     1801 taataaatct tttcccctct aactagaaag accaggttat gtactccaca tagcctggtc
     1861 ttcttttcgt cttattcttt atggttggta gaaaattgca ccttggtcaa caattacatc
     1921 tggttgcaac ttacgtaaac tcttactttc aacacaatat tttgtattat tcaaatactc
     1981 tttgaagttc ttagtttcca agtgctgctt gtaagcttca ttattacgat aaacttcaat
     2041 agctaaccat tcatttggtt gatcggcaac agttcctgca atcattgcca aaatatcttt
     2101 ttcttcttcg actgccgttt tcatttcttt cattacagca tgagcaaact catcgccctt
     2161 acctaaagaa acaccaattt cagtcagata aataacataa tcatttgatc cggtaactgc
     2221 tagtttttct gcctttgtag aaataaattc cggaaacaat tctaccttta ctcgactagt
     2281 taaaatatct ttagcaacgt cagtaaaatc cttaaattgc tttgaattag catgagtatc
     2341 ataacttgct tcgtcttgat agcattctac tacaaaatta gtagtttctt cgtcatgact
     2401 tgtctgcata aacaatgtgc ctggttcgtt ttcttgagaa gtaagcatat tatgttgccc
     2461 tgccttaacg aactttgcat gatcctcttt attagtttct agtttatata aacgcaaaat
     2521 tggtgtttgt tttaatttca taacttctcc tccaagaatt aattttgtca ttattatact
     2581 aaattttatc gcgtctatta gtaaaaaaca tcccttagtt aagggatgtc acaaaactat
     2641 aacgtgtaat taactttctt aaacttgtag tccttcattt ttttagctaa tttcttgctt
     2701 ctgaagtagt taccaccatc atatctacta gaataaacca gcacgttatg ctttttacca
     2761 ttaatggttt gtggtaccac tcgataaaga ctccaatttt caaaagtaat ccacggatca
     2821 atctcataga atgtatcatt cttcattttg gtagttttac cagacatcca gttttgcgtt
     2881 accttatcaa agttcttctg gttagcaatt ctaccattga agtaatcact aattgtcgaa
     2941 gcctcctggg taaatattgg tttgccatta acagtatgtt cagtaaaggt gatctttgtg
     3001 ccattatgtg cattacgatc ataagagtac caagtaccct gcatcttttt tggaatagta
     3061 acctgtacac cattaccata agttgaagca tcaacagtct caacttgact agccaaacca
     3121 gttaatccta aaacaagtac cattgatgtt aaaggtaaca aagttctttt tagcataaaa
     3181 atcatctcca gaatgtaaaa tatatgagtc cgctttcata atatatttta cagtatctta
     3241 tagtacttag acaagatatt tttaacttta cagattaata ttcttgctgc aatagcttta
     3301 taaactcact acttaacgct gaatttgact tataaaaagc cattatcttt tgctttatta
     3361 actgaccatg atcaagcaag aaaagtggct gcaaatctgt agtattaatt aacctagccg
     3421 tattctcatt taaaataaaa tagccagacc tagaggcgac caacagtgct gcttcttcga
     3481 ccgagttaga agcgatgaat tgactgccaa tttgatacaa atctttaaat aaatgtagct
     3541 cactaacctc ttcttcaggt ttagccacaa taaaacaagt catatcattg agctcgtctt
     3601 tttcaatcat ttgaatgcca ttaggataca ttcccttggg caaaattgcc attacaccag
     3661 cttgagtcaa ttctgtttca tcaaagttaa gattctcgtc acgcaaatca ttgattgcta
     3721 tgtctgcttc atcttcattc agttttgcaa aagcaccatc atgactagtc gcaagtagtt
     3781 ttacatctac attaggatgt tttaacacaa aatgctgcac tgcctgatct aattccttac
     3841 gacctaattg gtcaaaatat gcaatcttta attccgtcat tttatttttc atccagcggt
     3901 gcgtgtcctt cttctgctac tcttctttta tccttagtat cttcatgctt attaagtgcc
     3961 atcaaggcaa aaaagatcaa attcaaacca ctaactacaa tgccaaataa ttttattaaa
     4021 ttgagtttct tttctttact cattttttaa cctcacaact aaaaataatc ataaaatgat
     4081 acatcgcctt taacgaaatc taattttttg atgcggtaat ctgtaattaa tcctagttta
     4141 acagcagcat tcatggttag tctacctaat agcacctggg tccacgcggt aattgatccc
     4201 gaaaaatcaa ccaatgcatc ttccttacgt tctaccgcta ccttacgtcc atgattactt
     4261 aattgccaaa ctccaatatt ccaaggacac tgttcatcgc tattgacttc cagattaaaa
     4321 tcaccttctt gcattggccg catacaagcc aaaacttttt caaaatcaat aattcgactc
     4381 atcatataag gacgcaaatc aacttggagt tcgttttgtt caggaaaaag ttcagctcgt
     4441 aacgatttct ctggtacgct cattttaaat tgcttaacac tgcccgcgtg cgaacccata
     4501 aaaccaaaca tactcaataa tccctgcggc gtaattgcgt acatttcatc agctaaaaaa
     4561 gtattgtctc taatgcgata aatcaagtaa ctaattggcc gctcatccgc gtcaaaataa
     4621 acggctacat tgcggtgatg ataataagaa tcaagtctat tccaccacca tgcctcacgt
     4681 acaaccgtgt tacgttcatc atcagtatgc agttgacgtt cataaagttg aatcacacca
     4741 ttttgaacag ctaaattgtc ccacttgcca cgcactatat gaccagaacg tggtaattta
     4801 aaactacgca atgcgcttcc atcaaagcga tattcttttt gataaatact attgctaaac
     4861 ccgtactggc gataaaagct ctccgaaaat ggtgccaggt tagcaaacgg aatatcttgc
     4921 ctatgtaagt catgcaaaat ttctttcatt aattgggaaa tatgaccttg gccacgatac
     4981 tcaggatatg aagctacata acctattcca gccatcggta aatgatgccc aaaaacatca
     5041 cttttaaatc gattaaccat aatatagcta gctaattttt ccttatcaaa atagccataa
     5101 cctgtactat gatcataacg actcataaaa ttttcgtctt tagtcaaatc attatttttc
     5161 aaaaatgcat attgaattaa tgccgtaatt tgctttaaat tattcttatt tttctttaat
     5221 tccatgctta ttcctatacg tacatctata aatttattca ttactatttt agttcatttt
     5281 ttaaattttt aactagattt ttcataaaaa taaaccggaa tcataaaatc ccggtttatt
     5341 ttacgcaacg tattcttgat aaagctgaga gataaatgcc tgcatctgtt ccactgaatg
     5401 tctccggctg cgagcacatt ctttagcagg gcgatcacat aaaaagcact tacgtggctg
     5461 cctgcccaaa tctctgcgtg aaattgcagc ttgtttattt tttaccaaca cgtctgcatc
     5521 aaagagacgt cccaatgata tctgattctc aaaatcaatt gttgagcgct ttactttttc
     5581 aattgacaaa gataatacat aaaagttttc acagccacta tcatcattaa gctgtgtcac
     5641 caatttaaaa tgataaccta ggttagtcca agcattttcc agctcattga tacccaacat
     5701 aaacatttta gttaaatagc gattattctt gattggtcct gggatattca tattaatgtc
     5761 gactagagtt tgattaggat acttattaaa aatcttatgt tgtacagcta ctcgcctatc
     5821 tttagctgct aaaacttggg caatatcctg cttttttcct tcattaaaaa tattcatttt
     5881 tatcacccag ttaattataa atgattgtgc cgactccgtc tgctagtttg ttggcattgc
     5941 tcaaagaggt gataattgct aaattacctg ttttttctac aaattcaatt gcagcttcta
     6001 tcttaggctt catactccca gctgcgaaat aacctgctgc tagatattgt ttgagctgtt
     6061 caacttttat tttaccaatt gcttgttgat tttctttgcc ataattcaaa aatgcatgat
     6121 ccaccgttgt tagaattact aattcatcag cgttgatatc ttctgccatt ttagcagcgg
     6181 aaaaatcttt atgaattacg ccggcaacac ctctgagatg cccatctttc acaataacaa
     6241 ggatgccacc accgccacag gcaatcggaa taaataaatt tcctaaagta gccgccatca
     6301 ctgctttaat tgaatgcaat cgattttcag cttctgtaaa ttgccaagca tactttgaat
     6361 taaagacctc atcagttact tccatctcat ttaagccata tttttcatag atttcttctc
     6421 ccacctgagt tgttcgatca tgaaaagctg tcaaacaatg cataaagatc aattggtcat
     6481 ctggtgtacc agtcatttgc atcattttca ttgtgaccgt atatggcttt aataatttaa
     6541 ttcgttcaga ccaatcattt tcacccatcg aaacccaaac atcggtataa acaacattgg
     6601 ctcctttaac gccttgagca atatcatctg tgatcaaatt ttttgaacct gaatcttggg
     6661 caaaattttg agcaattttt tgtacatcag gatgtgtaaa caaaggcttg ggtgtaacaa
     6721 tatgtacatt aacacctaac attgagccac aaactaaaag actgtcggca acattatcgc
     6781 ggccatcacc cacttccaaa caggaacgcc agaatattta gccagctctt ctacatcttc
     6841 ttgagcaaaa ccgcgatatt caattccatc atacattgag cctaggactt tagccgtatc
     6901 cttgacgctt tcttttttac ctaagtggat ctcgcttgcg cctagatatt ctggatgagc
     6961 acctaaatca ttacaagcta ctacaaaagc agatcgcgtc ctagttgagg ctttttcaaa
     7021 aagtagtgca atatttttac ctttcagata ttcatgtggg atatgctctt ttttaagttc
     7081 ttttaaatgt aatgcaaaat caattaaata tgaaatttca gctggagtat agtctttaca
     7141 atcgagaaaa cttctacctt gaaaaacatt ttgtaaatat ttcatttttt gcctcttata
     7201 aatcttcacg aatcaacgga cacgacatac atctaggacc gccacgacca cgtgagagtt
     7261 cactagaccg aatctcatga acgatgatgc catgttttct tagcaaatca ttggatacat
     7321 aattacgatc ataagtaacg acttcacctg gtgcaattgc caaggtattt gagccgtcat
     7381 tccattgttc acgtggtgcg gcaattggat caccaccacc agttggaatt aaatccaatt
     7441 cgcttaaatg taagttttct ttcaaaacct gcaccaaatc attcttttct gtgattttta
     7501 caccgttgtg atcatcgggc tgtagaacat aaatatcaat tttgccggct ttatctaaaa
     7561 taaagggatg aaccgtaaat tgattataat taatcattgt aaaaactgta tcaaggtgca
     7621 tcatagcatg attgtgcgga atcttaatcg ctaaaatcgt atcataactt gaatgatcaa
     7681 ataaattatg agctaagtca gtaattgcag ttgcagaagt gcgttgtgaa atacctacag
     7741 ctaacacatg gttatttaga actagttcat ccccgccctc aaggcgacca tgatgataac
     7801 ggtcacgcca aactggaata gttgcgttct tgaaatcagg atgatttttc aaaattgttt
     7861 ccataaataa tgattcacgt cgtctagctc tgaaagtcat ccggttaatg gtcatccctg
     7921 aaccaattgc agcctgttga tctcgagtaa aatatacatt tggcattgga tcaagataaa
     7981 aagggtaatc tgggtcctca gccaaatctg ctaaagatgg ggtagaatta tgaatcgcac
     8041 tttttctaat tccagcaatc accgttttta ccatttcctt agttagcaat tcttggagat
     8101 agttcagcaa taattgatgc aaaggatcct gttttttaat acttgattca tccagtaact
     8161 gatctaagaa tgcccgacga actttctcat ctgttaaaga ttctgctaat aaatcctcaa
     8221 gatataatac tttgatcccc tgctgcctca atacatgcgc aaaagcatca tgttcttctt
     8281 gggcaatctt cagataagga atatcgtcaa tcaacattcg atgcaaaata tctggggcta
     8341 gattttctag ttcttttccc ggtcgatgta acatcaccgt ttttaactta ccaatttctg
     8401 aataaacatg aatcggactc gacattcaac caccttctat taattattgt acccgtttac
     8461 atttattatg gatcaattag gtaaaagtta cagtattatc atattgcagc aatgattttt
     8521 ttcattaaag gtgtaacttg atgatcttta cgccaaacca gctgcaaatg tgttatccaa
     8581 ttagcatgtt taattgcgat catattttct tgggcataag ttgtcgcaat tgattctggt
     8641 actagcgcta ctcccatttt tctcttggcc caagtaattg ctgtccgtga atcatcacac
     8701 ttaaccgcat aaaatggttt aagcccatga tgtgcaaaag tttgattaaa aatatcctca
     8761 aagcgacgat aaataatcaa tggctgatct gctagatctt taatgcgtaa ttcttttttt
     8821 tgctgaaaat ctgggtctac actaatagcc atcatttttt cagttgttaa agtcttagta
     8881 tttaaacctg tctggttgta aggcgttcgt acaatgccta gatcgattgt ctttttttct
     8941 aatttatcca ggatgccata agtattatct tcataaatat caaaagaaat ttccggataa
     9001 tattttcgta attcattaaa agaattcatt ggtatcaagc ccgttgagga agatgccatt
     9061 ccaattgcaa tcgttcccaa ttcaccggaa atagtcttat gtacttggtt ttcagcattt
     9121 tgagctagag aaataatttc attggcatag ctttgaaaaa tttgtcccac atcagttagc
     9181 tcaataccat gtgccgttct tttaaataat tgcgcgccca actctttctc taattgtttt
     9241 aattgatagc ttaatggtgg ctgtgcaata tacaagcgct tagcagctgc tgtaatctgc
     9301 ttttcttctg ctacaactag aaaataacgt aactgtttta gattcatatt atttatcctt
     9361 tttttatttc aattgatagt gatattaaaa tatttaatat cttatattgt attttagtat
     9421 tttattcata gcaatatctg tgctacctta ttaaggtaga tttggaggga aaataatgtc
     9481 tgataaattt cacggcttaa ctcaagccga agcagacaag cgcttaaaag aagatggctt
     9541 aaatgaagta ccagagcctg aatacaattt ctttaaagag ttcttgtcta agttatggaa
     9601 cctatccgct tggattctag aagctgcttt aattctagaa tgtatcttgg gcaaatgggt
     9661 ccaatcatta ttcgtgttgt tgatgctttt atttgctgca tttaacggtg catctaagaa
     9721 aaagcaatca agacgagttt taaataatat ttcacacaag ttgactccta ctgtatcagt
     9781 tgaacgcgat ggcaagtgga tcaaacttga ttctaaacaa ctagttaaag gcgatttaat
     9841 ctcacttaaa cgcggggacg tactcgcagc agatgttaaa attgttgacg gtaacttagc
     9901 ttgtgatgaa agctcaatta caggtgaatc taaaccagtt aagaaagcaa ttgatgacac
     9961 cgcctttgcc ggtactacag ttgttgaagg tgatggccta gctgttgtta ctgctacagg
    10021 taaagattct agaagcggta agacgattaa tttgatcaac aattccgctg ctcctggtca
    10081 cttacaacaa cttttgacta agattatcta ctacctttgc ttactagatg gtgttttaac
    10141 cttagttatt attatcgcct ccttcttcaa aggcggtaat ttcaatacct ttattaatat
    10201 gttgccattc ctggcaatga tgtttattgc ttcaattcct gtagcaatgc catcaacttt
    10261 tgctttatcc aactcatttg aagcaacccg cttaagtaaa gaaggagtcc tgacttctga
    10321 cctaactgga attcaggacg cagctaactt gaacttgctt ttacttgata agactggaac
    10381 aattacggaa aacaaaactg ccgtagccgc ttggactgat ctaagtgact tgcctgacaa
    10441 agacgtgctt gctttagctg gagccgcaac tgataaacgt aatgctggta ttatcgatac
    10501 agcaatcgat gaatacttag tagaaaataa cattccagtc atgaatgctg aaaactttac
    10561 tccatttact tctgacactg gttattctat ggctgatgtt gctggacata atgtaaagct
    10621 tggttcattt aagcaattat ctttgatcga taaacatgcc gatgaagaaa tttctggaat
    10681 taatttcaag gcaggacgct cagtggcagt cttgattgac gataagttag ctggtgtctt
    10741 catcttacaa gataaagtta gaacagactc taaagcagct ttggctgaac tcaagaaacg
    10801 tggcgttcgc ccaattatgt taactggtga caatcaaaag accgctgctg cagtggcaga
    10861 acaagttgat ttaactggta aagtaatttc gattcacgat ttcaatgaaa atactgatat
    10921 taatgatttg gccggtattg ctgatgtttt accagaagat aaactcaaga tggtaaagct
    10981 tttccaagaa aaaggctata tcgtagggat gacaggtgac ggagttaacg acgcgcctgc
    11041 attaaaacaa gctgaagtag gaatcgcagt ttcaaatgct gctgacgtag ctaagcgttc
    11101 gggtaaaatg gtattactag acgatggtct aggctcaatt gttaaaattt tagacgctgg
    11161 acatcgcgta taccaaagaa tgactacttg gtcactaacc aagcttgcta gaactgctga
    11221 attaacgatg ctgttaactt ttggctatct tttctttgac tacatcccaa tggccttgaa
    11281 tgcaatggtt atctatacca ttatgaacaa tatggttacg atgatgattg gaactgacag
    11341 gactcacatt acttataagc cagaaaactg gaatatggct aagcttgcta agatcgcctt
    11401 ttcactagct gctggttgga ctttaattgg tattgggttt gtttggttct taaacacaca
    11461 cggttggagt cacggtgctg tttctactat ggtttacgta tacctagttc ttagcgcaat
    11521 gttgattgtt ttgattacta gaactcgtaa gtacttttgg caagattacc catccaagtt
    11581 ggttggtagt gttcaaattg cagatgttct attgaccttt atcttagctc tttgtggttg
    11641 ggcaatggtc cagatttcca ttcaaaactt agcaattact gtaattgtag cgattattgc
    11701 tgccataata atcgacttaa tttaccaacc tgtgatgaaa aacaggtaga ttattaccat
    11761 aaattttata aattaaaaga cttctaggaa ctttgaactc ttagaagtct tttaatttat
    11821 ctttttgatt cacgatatcc tgctgcacgt gctgctgctt tactcttgaa gaaaactgca
    11881 ttttcacgat tcattcgata attatgaccg cgcattacgt gaaagatttt tgatcgttta
    11941 ttatcaacaa ttctgtaatt actggtataa atcttagttt tatcacgata ttgatgcttt
    12001 ctccttctgt gatgaatagc tgcattaaca actgatgtcg acccctgcaa atttgcaggc
    12061 agaacactga tttctcccac taacatcaga aatgcaacaa tagtcacaac ccaattcttg
    12121 catcttttca taaaaacact cccttaatat gtcactatat ttatatagta tacgtttata
    12181 tatgaagtgt tcctacgttt attagaaact agtttgaaac tgtcaaatct tttgtgtaaa
    12241 tagttctttc tcgtaaattg atttttt
//
