LOCUS       c00001_JAKVNP0..       14698 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAKVNP010000001.1 MAG: Lactobacillus crispatus isolate UW_TS_LAC1_1
            Ga0455836_009, whole genome shotgun sequence.
ACCESSION   JAKVNP010000001
VERSION     JAKVNP010000001
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 19:22:09
            Original ID  :: JAKVNP010000001.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2237042
            Orig. end    :: 2251740
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14698
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[2242042:2246740]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9698
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..14698
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14698
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(535..1071)
                     /locus_tag="ctg1_2164"
                     /transl_table=11
                     /translation="LNHDAKITIARYAVQNFVRPGDNVFIDAGTTTYEMVPFLAEVANV
                     KIITNGVETALCSLNHGINTILIGGEVKDDTHAVIGQTALSQIKAMNFSASFVGANGIE
                     KNGNLTTPDPEEAAVKAAEIKQARHAYVLTDNSKIGERNFAVFANTSDVIVVTDQLKPG
                     QKRSLPVGIELEEAK"
     CDS             complement(1142..1294)
                     /locus_tag="ctg1_2165"
                     /transl_table=11
                     /translation="MMLTQERQSLIEDYVNQHELCRVSELCDLTATSESTIRRDLIQME
                     KKWDP"
     CDS             complement(1545..1730)
                     /locus_tag="ctg1_2166"
                     /transl_table=11
                     /translation="MMNEVLNATELHFATKKFTAEDMVTMLEEQGWGQEEMHFAENKIS
                     AGEMASMLEGLGWKEN"
     CDS             complement(1970..3184)
                     /locus_tag="ctg1_2167"
                     /transl_table=11
                     /translation="MNKIWLVAKETYRREVKTWSYLLMILAPFIFAFLSVGIGMITASS
                     GDDNYIGVVTSNPALKQAVKKSEDFDNYATKAKAQKAYKDEDIDGYVLVEQKNNQLTAT
                     YYSNEKMDSDVKSELLTSMQAVQHQLNLRQAKLTAKQSAALATQVQFKQTVKHSEKKSF
                     DSDPVKQISFWILLIILYMLVITYTQVTAQDIATEKGTKMMEVIFSSMPGGDYFTGKIL
                     GIFGEIITQVLIYVAGFTAVYFVAPYIDGFNDLFNKYKPMIDQAIGNLVSWGLLFTIIG
                     LILFIIFAAFCGAIVVKSEDANKAVTPLTVLMLIGFLFTLNMSSGNDTILAQVLSYIPF
                     LSSFVMPARVIMGDASNLEATISALIALIAASGSFIWIRKIYPGLILQTDDVGPWQNFK
                     RSLLN"
     CDS             complement(3177..4073)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 170.9; E-value:
                     6.1e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2168"
                     /transl_table=11
                     /translation="MLKIEHLNKSFGKTQVLFDVSFDVQDGRILGLVGKNGSGKSTIFH
                     SILKFVDYTGQISINGHSFSAKDYDDIGYLPEERSLMPKLTIVDQVSFLASLKGMPAKK
                     VKEELPDWMSRLAVKGIPMDKIKSLSKGNQQKVQMIATLIHQPKLIILDEPFSGLDPVN
                     VDLMKQLILEEKRLGATIIFSDHDMRNVEELCDDVVMINDGRIVLNGPVNEIKNSFGLT
                     RIFVRTDKNADELMTLPGVKDVILQNNGIKLLILDDEKYGREIFDTLSAGQYIQTFDQE
                     PPTLDEIFKMKAGAHHE"
     CDS             complement(4174..4374)
                     /locus_tag="ctg1_2169"
                     /transl_table=11
                     /translation="MKQIIISENELLLSRILGGSESIIDIGLDDTEHMLPLYSKKGGNH
                     KRDIYLENPRFFRRPFSRGRH"
     CDS             complement(4397..4990)
                     /locus_tag="ctg1_2170"
                     /transl_table=11
                     /translation="MSSKDYESTEFYSYKFKNFSTMIIVPMAILVLILIISSFFVVRQS
                     TVTSTGIIEPENTLNVANKNYHEGQVIRKNRNNWLVHMDDKQENLVHLLPIVRAKSKIN
                     VITYFSGNKIGAIKKGQVLHFQLSNANGTTDRVIGKVKEIGVYPVNVHGNNAYEVICEA
                     KPNKDVKYGMEGNATIITGKSTYFEYFKDKILNQ"
     CDS             complement(5001..7163)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 306.2; E-value:
                     7.8e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2171"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1062.1,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.4e-43, bitscore:
                     143.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIQYKSIYVPQVDESDCGVACLAMILKKYHSRVSLAHLRHSART
                     NLEGTTALGLVKTAQAFNLNTQAVKADMSLFDPDTDIQYPFIVHVLKQGELLHYYVVIK
                     ATKKYLIIADPDPSVGLTKMAKDKFAQEWTGIALLMAPNDKFEPIKEKKRNLWSLFPYM
                     FKQKNLLTNIILASLLMTIISICSSYFLQGVIDTYIPNGTYQTLSILAIGLLIAYVFNS
                     IFSYGQSLLLNVLGQRLSIDLNLQYIRHLFELPMEFFVTRRTGEITSRFSDASRIIDAL
                     ASTVISLFLDLSIVIVMGIVLAIQNSTLFVITLLALPVYAVVILSFSKKFEKMNNDQME
                     SNAVLSSSVIEDIQGIETIKALNSEQTRYRKIDSQFVDYLKKSFRYSKTESLQSALKTF
                     IQLSLNVIILWVGAKVVMNGQMSIGQLMTFNALLSYFVDPLQSIINLQPTLQSANVAQN
                     RLNEVYMVKSEFKKDAQIRDAKQLIGDIEYQNVDYHYGYGVAVLKDINLKIKYNDKLAI
                     VGMSGSGKSTMVKLLVDFFSPSKGKLTFNGFDSTKVDKHVLRSYVNYVPQTPYIFSGTI
                     KENLLLGSRADITEEDVLRACQIAEIEAEIEQLPLQFETKMDENAKILSGGQKQRLTIA
                     RALLSPAKILIFDEATSGLDTITEKKVVDNLMKLKDKTIIFIAHRLAIAQRTDNIVVLD
                     HGQIVEQVSYDELMQKHGFYYNLVEN"
     CDS             complement(7457..7612)
                     /locus_tag="ctg1_2172"
                     /transl_table=11
                     /translation="MNRKRRWSIYIIILIITVIVCGALIHYGHYKTAPILAVIVITIIA
                     INNAKP"
     CDS             complement(7683..7907)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2173"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.1e-12,
                     bitscore: 44.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVEVLSEEKLSAVVGGKTKHPKARAWTFTGAGIAHSTLYGAAA
                     SALGVTGPAGWAAGAAVGAVYGIASAAFC"
     CDS             complement(8135..8353)
                     /locus_tag="ctg1_2174"
                     /transl_table=11
                     /translation="MILSIKKKINFESDALGVLLPLVMASAYVTNNTSIGYSNLATIAV
                     GIFIPVYFLGKHSIFTIGEIRNENINI"
     CDS             complement(8454..8867)
                     /locus_tag="ctg1_2175"
                     /transl_table=11
                     /translation="MTKKQITIRSIIVGCLYFVLDLALSVVLKESVTTIYVLETMFESI
                     LFTVFMIWLLKMNKDSKKINSNGSFLKYFSIGMKGSWIIFTIMLFLKVGNRMSKVMVDD
                     TALLIGTYLVVGELALYIVFRKATKSDWFRKSR"
     CDS             complement(9023..9334)
                     /locus_tag="ctg1_2176"
                     /transl_table=11
                     /translation="VVLASTVFKDIGCINMVVSVIILCSIILILWITISLGETICNKKN
                     GVYVYKHREYKRINGKIMVVKVEDEKYSSIAAFTAYFINNFKSLFMFIFPSILDKLFF"
     CDS             complement(9309..9467)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2177"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.9e-09,
                     bitscore: 34.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVNDSELAQVVGGNGNKCLKGIAVSAGWGARHGWVGALIGAVG
                     GFGKHCI"
     CDS             complement(9483..9698)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2178"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 1.8e-09,
                     bitscore: 34.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVEVLNEEELTTVVGGNKGTGRKVMRCVLSVGSAFAQSVWAKT
                     NPYLAGANLAYNTGKYCFDLGPQKVY"
     CDS             complement(10016..10888)
                     /locus_tag="ctg1_2179"
                     /transl_table=11
                     /translation="MAQVKDLIAKQDNQDRVMYIGRPTCYYCRQFSPDLKDFNKIDKGK
                     LLYFNIDAEKNAHEYAFKVIGIPGTPTTMRFINGKIVSAWIGGEKTGQELYDFLYSPES
                     NKLVESLTIKDDSQQKKTNSDLDEVDDQQVEQPITDDVQEDSHLVISISDTVFADANNV
                     ASSNSDLSQVANLDNENELGSVKSEDVESKKVSHKAKQVNASSKQKAVKKKLTTNYEGK
                     RIKDARKEKMNFDTKSVLAIKSTEHMKTSKLELPQTSENNSSVLPVLGAMILVISSLLG
                     AVEKLWKKA"
     CDS             11291..12469
                     /gene_functions="other (smcogs) SMCOG1130:transposase
                     (Score: 392.4; E-value: 2.8e-119)"
                     /gene_kind="other"
                     /locus_tag="ctg1_2180"
                     /transl_table=11
                     /translation="MNDFTKDMTNALFNQDKINDLFRQKLQQAVNDLLESELTAFLGYN
                     PYERDGWNTGNSRNGAYYRKVDTQFGQIEIKVPRDRNGEFHQHTMPDYKRHTDVLEQTV
                     IKLYSKGVTTREIADLIEKMYGGYYSPAMVSNISKEMIPKVEAYHQRHLSDKFFCVYLD
                     ATYIPLKRVTYEREAVYIAIGIKPNGHKEVIDYCIAPTENIEIWSEMLKGFKSRGLEQV
                     ELFLSDGVVGMKEAICQSYPKAHFQRCLVHVMRNISAKMRVDDRQKALDEFKQIHTQSN
                     KEMAVQVLHEFYQNWEKAYKNVVRDLRQVEPDLLTFYNYPPAIRASIYSTNMIESFNNR
                     LKRKTKPKTEFPTEQSLDTFIGVQAMDYNDRYFNRIHKGFGQVRDTLESYFD"
     CDS             complement(12490..12612)
                     /locus_tag="ctg1_2181"
                     /transl_table=11
                     /translation="MNKKKILTLMASPVVLLMLNSAVVHADGDCQEVCVNNLSR"
     CDS             complement(12753..13565)
                     /locus_tag="ctg1_2182"
                     /transl_table=11
                     /translation="MKIVTTNYPIIVCDDDPDLANQLATNINSAIQDLAGDNSSYSELK
                     ERVTFVANDFAQVVGYIVANDIKNGIYFLDIELSQQSEAKNGVDLAEFIKKQDENAQII
                     FVTAYDKYAPLTYRRRIGAIDYISKNLSSDEIIQRLEETLRGAISNLTNMVKYGNRNFK
                     YKIGRNVFKVSENEVFYIENSTMQHKVHMVTEHGDVEFKGNVSQVAKNADFLTKVSQSA
                     LVNPNNVKAIDTHNKLIIFDKDNIISYSRAYKKNIKQLMAEFETIDVI"
ORIGIN
        1 attactagtg gcttatatgc caaagtatca agtaaagctt gtccagtagt atcaacaaca
       61 aattctgcac ctgcttcttt aatagtagga agcaatgatt gatagaaatc agttggaagg
      121 cttggagtaa gagaaccgct cattactaca atgtcgccct tctttaaatc gttcaaacga
      181 tccttaaaag cagtaatttc ttggtcggta atgttaggac cagccgcgtt aatttcagtt
      241 tccttttcag cgtggatctt aacattcaca cgagtgttgt ctgaaatggt aacgaaatca
      301 ctttcaattc tcttttgatt caattggcga accaattcct tgccagtgaa gccacctaca
      361 aagccccatg ccgtattatc aacatttaat tggttaagga tttgagaaac gttaattccc
      421 ttaccccctg ctaaaaatga atcattgtta gttctgttaa cttctccgcg gttaactttt
      481 tctaattgaa gaacatagtc aagcgctgga ttaacagtta ctgtataaat catcctattt
      541 tgcctcctct aattcaatac cgactggtaa tgaccgtttt tgacctggtt ttagttgatc
      601 agttaccaca atcacgtcac ttgtattggc aaacacagca aagttacgct caccaatttt
      661 actattatca gttaatacat aagcgtgtct tgcctgtttg atttcggctg ccttaaccgc
      721 agcttcctcc ggatcaggtg tagttagatt accatttttt tcaattccat tagcaccaac
      781 gaagctagct gaaaaattca ttgccttaat ctgacttaag gcggtctgac ctataacagc
      841 atgcgtatcg tccttaactt caccgccaat tagaattgtg ttaatcccgt gatttaaact
      901 gcataaagca gtctctacac cattagtaat aatcttgacg ttagcaacct ctgctaaaaa
      961 tggtaccatc tcataagttg ttgttcctgc atcaatgaag acattgtcac ctggacgaac
     1021 aaaattctgc acggcatatc tagcaatagt gatttttgcg tcatgattca aactgaagcg
     1081 aacgttttgt gatacatctc gagaaaaatg cttaactgat tgggcaccgc catgaacacg
     1141 cttaaggatc ccattttttt tccatctgaa ttagatctcg acggatagtt gattcagatg
     1201 ttgcagttaa gtcacataat tcacttacgc gacataactc gtgttgatta acatagtctt
     1261 cgattaagct ttggcgctcc tgagtcagca tcatttttca cctcgataaa cattgtattc
     1321 gctttcctat tcaaaatcaa tcattttcct tcaaaaaatg tcatttttat ttattatcgt
     1381 tcaataagat tcattaaaat tcatttttta gcaaaaaaag accaatcagc atgaattatc
     1441 ttcatactaa ttggttctag ttgattggcg cttacgataa tatgaacaaa cgctttaatt
     1501 taatgtttaa atattatgta tacgtgcttt tttaattaag aattctagtt ttctttccag
     1561 cccaagcctt caagcattga tgccatttca cctgcagaaa tcttgttttc agcaaaatgc
     1621 atttcttctt gtccccaacc ttgttcttca agcatggtta ccatatcttc tgctgtaaat
     1681 ttcttagttg caaaatgtaa ttcagttgca tttaatactt cgttcatcat cgttattacc
     1741 tctcaaacac ttaactctct cttcatttat tataataaca cgtgttatct aaaaataaca
     1801 gtgttttttt gaaatttctt tgatttttta tttaagaaag tctttaaaac gttgataaat
     1861 caagcttttt atgatttaaa tttagtcgaa ataattatga taaataacaa aaataacact
     1921 aaatatcaca aaaacagcag gattatttcc tgctgtcttc gtcgctattc taatttaata
     1981 ggctgcgctt aaagttttgc cacggaccaa catcgtctgt ctgtaaaatc aaacctgggt
     2041 aaatcttcct aatccagata aatgaacctg acgctgcaat taaggcaatt aaagccgaaa
     2101 tagttgcctc taaattgctt gcatccccca tgatcactct ggctggcatt acaaatgatg
     2161 ataaaaacgg aatgtacgat aatacttgag ccaaaatcgt gtcgttacct gatgacatgt
     2221 ttaacgtgaa taaaaatcca attaacatta ggaccgtcaa tggtgtcact gccttattcg
     2281 catcctcgct cttaacaacg attgcaccac agaaggccgc gaagataatg aataagatca
     2341 agccaataat agtgaaaagc agtccccaag agactaaatt gccaattgct tgatcgatca
     2401 ttggcttata tttattaaat aagtcattaa agccatcgat atacggtgcg acaaaatata
     2461 ctgcggtaaa accagcaaca tagattagta cctgagtaat aatttcacca aaaatcccga
     2521 gaatctttcc tgtgaagtaa tcaccacctg gcatgctgga gaagatcact tccatcatct
     2581 tggtcccctt ctcggtggca atatcttgcg cagttacttg cgtgtaggta attactaaca
     2641 tgtataaaat aattaataaa atccagaaag aaatctgctt aaccggatca ctgtcaaagc
     2701 tcttcttttc gctatgcttg acggtctgct tgaattgaac ttgagtagct aaagcagcac
     2761 tctgcttcgc cgtcagtttt gcttgacgta aatttaattg gtgttgaacc gcctgcatgc
     2821 tggtcaatag ctctgactta acatcactat ccatcttttc attactatag tatgttgcgg
     2881 ttaactgatt atttttctgt tcaactaaaa cataaccatc aatgtcttca tctttataag
     2941 ctttttgcgc tttagcctta gtagcataat tatcaaaatc ttccgacttc ttaaccgcct
     3001 gtttcaatgc tggattagaa gtaactacgc caatataatt gtcatcacct gaactagcag
     3061 tgatcatgcc tattcccact gaaagaaaag caaaaatgaa cggtgccaag atcatcaaca
     3121 agtatgacca agtcttcact tccctgcgat aggtttcttt agctacgagc caaattttat
     3181 tcatggtgag cacctgcttt catcttaaat atctcatcta aggttggcgg ttcttgatca
     3241 aaagtctgaa tatattgacc agctgataat gtatcaaaga tctctctacc atacttttca
     3301 tcatcaagaa taagcaactt aatgccatta ttttgcaaga taacgtcctt tacaccaggt
     3361 aaagtcatta gctcatcagc gtttttatca gttctaacaa aaattctagt taagccaaaa
     3421 ctattcttaa tctcattcac tgggccgttt aatacaatcc gcccatcatt gatcatcacg
     3481 acatcatcac atagctcttc cacgttgcgc atatcatgat ctgaaaagat aatagttgca
     3541 cctaatctct tttcttccaa aatcaattgt ttcattaaat caacgtttac aggatctagc
     3601 ccactaaacg gctcatccaa aattattagc ttaggttgat gaattaaggt tgcaatcatt
     3661 tgtacctttt gttggttacc tttggacaag gatttaatct tgtccatcgg aattccttta
     3721 actgctaagc gagacatcca gtcaggcaat tcctctttca cttttttagc tggcatccct
     3781 ttcagactag ctaaaaagct aacctgatca acaatcgtca acttcggcat tagacttctc
     3841 tcttcgggca aatagccaat atcatcatag tcctttgcac taaaggagtg tccatttatg
     3901 ctaatctgac cagtatagtc aacaaatttc agaatactat gaaaaatagt tgatttcccc
     3961 gacccgtttt ttccgactaa gcccaagatc cgaccatctt gaacatcaaa gcttacatca
     4021 aacaaaactt gggttttgcc gaagctttta tttaggtgtt ctatttttaa catgagtttt
     4081 tcctcagctt ttctgttttt atttcttatt ttttcgatga tgaagatgaa atatttcact
     4141 caaaaaataa actaatataa aaatactaac tcatcaatgc ctacctctag aaaaaggcct
     4201 tcggaaaaat ctaggatttt ccaaataaat gtcgcgttta tgattaccac ctttcttact
     4261 atataaaggt agcatatgtt cagtatcatc tagtccaata tcaattatgg attctgagcc
     4321 acctaaaatt ctgcttaaaa gtaattcatt ttcagaaata ataatttgct tcattttact
     4381 tctctctcct tcattttcat tggtttaaaa ttttatcttt gaaatattca aaatatgtgc
     4441 tctttcctgt aataattgtc gcgttacctt ccatcccata tttcacatct ttgttaggct
     4501 tagcttcaca aatcacctca taggcattat ttccatgtac atttacagga tatactccta
     4561 tctcttttac ttttccaatc actctatctg ttgtgccatt cgcattagac agttgaaaat
     4621 gaagtacctg tcctttttta attgctccaa ttttatttcc ggaaaaatat gttattacat
     4681 taattttact ttttgctctg actatgggca acaagtgtac taagttttct tgcttatcat
     4741 ccatatgaac taaccaatta tttctatttt ttctaataac ttgaccctca tgatagtttt
     4801 tattcgcaac gttaagagta ttttcgggtt ctatgatccc agtagaagtt actgtacttt
     4861 gtctaaccac aaagaaagag ctaattatta aaatcaaaac taatattgcc atcggaacaa
     4921 taatcatagt tgaaaaattt ttaaatttat aagaataaaa ctcagtactt tcatagtctt
     4981 tactgctcat aaactgcctc ctaattttca accaagttat agtaaaagcc atgtttctgc
     5041 attaattcat catagcttac ttgctcaaca atttgtccat gatcaagaac cacaatatta
     5101 tcagttcttt gagctattgc cagtcgatga gcgataaaga taattgtctt atcttttagc
     5161 ttcatcagat tatcgaccac ttttttctca gtaatagtat ctaatccact cgttgcttca
     5221 tcaaagatca aaattttagc tggagacagt aaagctcgtg caattgttag tctttgcttt
     5281 tgcccacctg acaagatttt ggcattttcg tccattttcg tttcaaactg taatggcagc
     5341 tgctcaattt cagcttcaat ttctgctatc tggcatgctc ttaagacatc ttcttctgta
     5401 atatctgctc gactgccaag aagaaggttc tccttaatcg ttccagaaaa aatataaggc
     5461 gtttgcggaa cataatttac atatgaacgt aaaacatgtt tatctacttt agtagaatca
     5521 aaaccgttaa aggtcagttt gcccttacta ggagagaaaa agtcgactaa gagttttacc
     5581 atggtagatt taccggatcc actcattcct acaattgcca gtttatcatt atacttaatc
     5641 tttaaattaa tatcctttaa gacagctacg ccgtagccat aatggtaatc aacattttga
     5701 tattcaatat ccccaattaa ttgttttgca tccctaatct gagcatcctt cttaaattcg
     5761 ctcttcacca tataaacttc attcagtcga ttctgagcca cattagctga ttgtaaagta
     5821 ggctgcaaat tgataatgct ctgaagtgga tctacaaagt atgacagcaa tgcattgaag
     5881 gtcatcagtt gaccaatact catctggcca ttcattacga ctttagcccc tacccacaga
     5941 ataatgacat ttagcgacag ctgaataaaa gtcttcaaag ccgattgcaa tgattcagtc
     6001 ttgctgtaac gaaaagattt cttaaggtaa tcgacaaact gactatcaat tttgcgataa
     6061 cgcgtttgtt cactatttag ggctttaatc gtttcaattc cttgaatatc ttcaattaca
     6121 gaagagctca atactgcatt gctttccatc tggtcgttat tcatcttttc aaacttctta
     6181 gagaagctaa gaatcactac ggcataaact ggtaaggcta ataaagtaat tacaaataaa
     6241 gtggaatttt gaattgcaag aacgattccc atcacaatta caatcgaaag atcaagaaat
     6301 aatgaaatca ctgtgctagc caaggcatca atgattcgac tagcatccga aaaacgtgag
     6361 gtgatttcac cagttctgcg agttacaaaa aattccatag gtagttcaaa aagatggcga
     6421 atatactgta aattaagatc aatacttaat ctttgaccta gaacattaag taaaaggctc
     6481 tgaccataag aaaagatgga attaaatacg taggctatca gtaagccaat tgccaggata
     6541 gaaagagtct gatatgtgcc attaggaata tatgtatcaa tgaccccctg caaaaaatat
     6601 gaactacaaa tactaataat cgtcattaac aaagaagcta gaataatatt cgtaagcaag
     6661 tttttctgct tgaacatata aggaaatagc gaccatagat tacgtttttt ctctttaatt
     6721 ggctcaaatt tatcgttagg tgccatcagc aaagcgattc ctgtccattc ttgagcaaac
     6781 ttatcctttg ccattttagt taagccgaca ctaggatctg gatcagctat gatcaagtat
     6841 tttttagtag ctttaattac tacgtaataa tgcagtaatt caccttgctt taagacatga
     6901 acaataaatg gatactgaat atctgtatct ggatcaaaca atgacatatc agctttaacg
     6961 gcttgagtat tcaagttaaa ggcttgagcc gtctttacta aacctaaagc ggtagttccc
     7021 tctaaattag ttcgtgcgct atgccgcaaa tgggctaaag atactctaga atgatatttt
     7081 ttaagaatca ttgctaagca ggcaacacca caatctgatt cgtctacttg tggcacatag
     7141 attgatttat attgtattaa catatttatc ccacttcttt cagttctata agccaattat
     7201 gacaggagta gtaatctaaa agtaaaaaaa taccgaatta gtcgtttttt agactgattc
     7261 ggtatttgat acattactta atcaaagcaa ttatagcttg agaaaaataa ctgatgccta
     7321 atcccaagat aaagacgcca aagatgaaac cgataccaat ttccattaac ataaagccgc
     7381 tatctgtgcc cttttttgaa tactgtgtaa ccaatgttta ttataaaaca attctctttt
     7441 aggttgacga aattatctat ggcttagcat tattaattgc aataatagtt atcactatga
     7501 ctgcaagtat aggtgcagtc ttataatgac catagtgtat aagtgcccca cacacaatta
     7561 ctgttataat taatataatt atatatattg accatcttct ttttctattc attttggttt
     7621 cactccccaa aagagtatat aacctaccct tttattgatg atcgttttct aatagcttta
     7681 ttttaacaaa aagccgcact agcaataccg tatacagcac ctacagctgc accagcagcc
     7741 catcctgctg gaccagttac tcccaaggca cttgctgcag caccatataa agtgctgtgt
     7801 gctataccag ctccagtaaa agtccaagca cgtgctttag gatgtttggt cttaccgcca
     7861 actacagcag acaatttttc ttcgcttaac acttcaactt tactcatttt tattaccttc
     7921 tatgatgagt aatcaagaga aattcatctc ttatttcttt ctacattatt aaagtaccat
     7981 aaatagcttc attttcagga cgcatgatcg atttagcctt tttttgactg atttagcact
     8041 tgcatcctaa ttcagtacat tttttgtcaa atctagcact gttttacaac ctttatagtc
     8101 tctttactac actctgatat attttagtat attgctaaat atttatattt tcatttctta
     8161 tttctccgat ggtaaagatt gaatgcttac ctaagaaata aactggtata aaaataccaa
     8221 ctgcaatggt agcaagatta gaatagccta tcgaagtatt atttgtaacg taagccgaag
     8281 ccattaccaa tggtaaaaga actcctaatg catcactttc aaagtttatt ttctttttta
     8341 tactcaaaat catccacagt ataaatccta taaaagatga tactagtgga atatacgaaa
     8401 ataaaataca tactcgcgaa tacgtgctta ataatctctc atttattaac taattaccta
     8461 ctttttctga accagtcact tttagttgct ttgcgaaaga caatatataa tgcaagctca
     8521 ccgacaacta aatatgttcc aatcaacaat gctgtatcat caaccataac tttactcatt
     8581 cgattaccca cttttaagaa cagcattata gtaaaaatta tccaactacc tttcatgcca
     8641 attgaaaagt attttaagaa actaccatta ctattgatct ttttagaatc tttattcatt
     8701 tttagtagcc aaatcataaa tactgtaaac aggatacttt caaacatggt ttccaaaaca
     8761 taaatagttg ttactgattc ttttaaaact acacttaatg caagatctaa aacaaaatat
     8821 aaacaaccta caataatgct tctaattgtt atctgttttt tagtcataat gtttttttca
     8881 tgcttatagc aattttgaaa taaagaaaac accaaatcaa ttatttttta actgattcga
     8941 tgttaataaa attgagtgga tgttcttaaa agagattatc atatctcatt aaaataccct
     9001 aagtatagcc taatactatt gtttagaaaa acaacttatc tagaatagat ggaaaaataa
     9061 acataaataa actcttaaag ttattgatga aataagccgt aaaagctgct attgaagaat
     9121 acttttcatc ttctaccttt actaccataa tttttccatt gattctttta tactctctat
     9181 gcttataaac atatacacca ttttttttat tacaaatagt ttctcctagt gaaattgtaa
     9241 tccataaaat taatattatg ctacacaata ttatcactga aactaccata ttaatgcacc
     9301 caatatcttt aaatacagtg cttgccaaaa ccacctaccg ctccaattaa ggcacctacc
     9361 caaccatgtc tagcacccca acctgcagaa acagctattc cttttagaca cttgtttcca
     9421 ttgccaccaa ctacttgtgc caattcacta tcattaactt ttttcataat tttttctccc
     9481 ccttagtaaa ccttttgtgg acctaaatca aagcaatact ttccagtatt atacgctaag
     9541 tttgctccag ctaaataagg attagttttt gcccaaacac tttgtgcaaa agctgagcct
     9601 acacttaata cacaacgcat tactttccta ccagttcctt tattaccacc aacaacagta
     9661 gtcaactctt cttcgtttaa aacttcaact ttactcattt taaatacctc ctataatgag
     9721 taatcaagag aaattcatct cttgtttctt ttgacattat tacaatacca tggatagcct
     9781 caatttcagg gcacatgacg gatttaacct tttttcagac caatcttgca cttgcatccc
     9841 aattcggtat atcttttgtc aaaatttggt attaacgtca tataccaaaa aatactaagc
     9901 tatcacttcc atgctaactt agtatttccc catttatttt aaataataat cacattgatc
     9961 atagtcaaaa tatctgctcc aatgtggacg aaccacagag caaagctcca ccatttcagg
    10021 cctttttcca aagtttctct actgcgccta acaagctgct aataactaaa atcattgcac
    10081 ctaaaacagg caaaacagag ctattatttt cactggtttg tggtaattca agtttacttg
    10141 tcttcatatg ttcagtagat tttattgcta atacagattt agtatcaaaa ttcatttttt
    10201 ctttacgagc atctttaata cgcttgcctt catagttagt cgtcaatttc tttttaacgg
    10261 ctttttgttt tgaactggca ttcacttgtt ttgctttatg agaaaccttc tttgactcta
    10321 catcctcact ctttacagag cctagttcat tttcattatc aaggtttgca acttgactca
    10381 agtcgctatt actacttgct acattatttg catcagcaaa aaccgtatca gatatagaga
    10441 tgactaaatg actatcttct tgtacatcat cagtaatagg ttgctctact tgctgatcat
    10501 ctacttcatc caaatctgaa ttggttttct tctgttgtga atcatctttg atagttaaac
    10561 tctctacaag cttgttcgat tcgggagaat acaagaaatc atacaattcc tgccctgttt
    10621 tctcgccacc aatccaggca ctgacaattt tgccatttat aaagcgcatt gtggttgggg
    10681 tacctggaat accaatcact ttaaaagcat attcatgagc atttttttca gcatcaatat
    10741 taaagtacaa tagttttccc ttatctatct tattaaagtc ttttaaatct ggagaaaact
    10801 gtcgacaata ataacacgtt ggtcgaccaa tatacattac tcgatcctga ttatcttgct
    10861 tagctattag atctttaacc tgtgccatat caacgcgttt aaaatctttg acgttatttt
    10921 catattcttc aacagttaca tcatcctcat cagattcttc gtcttctact tgatcttttt
    10981 tagaatttga attatttgac tgcttttgtg aattaactgc atcaggagaa gtgtcttctg
    11041 tttccttgga tgaatcattt tctttcgttt gatcattttc agtagactct gcagtttgct
    11101 tttctccatt atttggctgc tgttctactt gttgattagt tttaggttct acctcatcag
    11161 cagagaccgt aaaatagttt gtgtaaggat gaatatttcc ttaattttat ttccctgaat
    11221 attagaaaaa ggaatccttt tcccgtatga ttgatttgaa cgaaaaacat actagaaaag
    11281 agattccttc atgaatgatt ttaccaaaga tatgactaat gctctattca atcaggataa
    11341 aattaatgat ttatttagac aaaagctcca acaggctgtc aatgacctgc ttgaatccga
    11401 attgactgcc tttttaggct acaatcctta tgagcgcgat ggctggaata ccggaaattc
    11461 tagaaatggt gcttattacc gcaaggttga tacgcaattc ggacaaatag aaatcaaagt
    11521 tcctagagac agaaacggtg agtttcatca acacactatg ccagattata aaaggcatac
    11581 tgatgtttta gagcaaactg ttatcaagct ctattccaag ggcgtcacaa cccgagaaat
    11641 cgctgatttg attgagaaaa tgtatggcgg ctattattct ccagctatgg tttccaatat
    11701 ttctaaagaa atgattccca aagttgaggc atatcatcag cgacatctgt cagataagtt
    11761 cttctgcgtt tatctcgatg ccacctatat tcctcttaag cgggtcactt atgagcgcga
    11821 agcagtttat atcgccatcg gtatcaaacc taatggtcat aaagaagtga tcgactactg
    11881 tattgcgcct actgaaaata ttgagatttg gagcgaaatg ctcaaaggct tcaagagtcg
    11941 cggccttgaa caggtagagc tcttcttgtc tgacggagta gttggcatga aagaggctat
    12001 ctgccagtcc tatcctaaag cgcattttca acgctgcttg gtacacgtca tgcgtaatat
    12061 cagtgccaaa atgcgggttg acgatcggca aaaagcactg gatgaattca agcagattca
    12121 tactcagtca aacaaagaaa tggctgtaca agtgctgcat gaattctatc aaaactggga
    12181 aaaagcctac aaaaacgtag ttagagatct tagacaggtt gagcctgatc tgttaacctt
    12241 ttacaactat ccgccagcta ttagagcttc aatttactca actaacatga ttgaatcctt
    12301 taacaacagg cttaagcgga aaaccaagcc taaaacagaa tttccaactg agcagtcgct
    12361 tgacaccttt attggagttc aggcaatgga ttacaatgac cgttacttta acaggattca
    12421 taaaggattt gggcaagttc gagacaccct agaatcctat tttgattaaa agataaataa
    12481 aaaagtcaat caacgagaga gattatttac acaaacttct tgacagtctc catcagcatg
    12541 aactacagca gaattcaaca taagcaatac cacaggactg gccattaaag ttaatatttt
    12601 ctttttattc attattgtca tactcctttt cttatttgac ccaagcatat catttaaata
    12661 tatgaagcag gacaaaccta ccaaagcaaa caaaaatatg acggattcgg tatataatta
    12721 ccaaatccgt catcattaga taatttttta ttctaaatta catcaatagt ttcaaattca
    12781 gccattaatt gcttaatatt tttcttataa gcccttgaat aactgattat gttatcttta
    12841 tcgaagatga tcaacttatt atgagtatca atagccttaa cattatttgg gttgactaaa
    12901 gcagactgtg agactttagt caaaaaatct gcattcttag caacttgact aacattacct
    12961 ttaaattcca catctccatg ttcggtcacc atatgtactt tgtgttgcat tgtactattt
    13021 tcaatgtaaa agacttcatt ctcactaacc ttaaatacat tacgaccaat cttgtactta
    13081 aagttgcgat taccatactt aaccatatta gttaaattac taatagcacc acggagtgtt
    13141 tcttcaagac gttgaataat ctcatccgaa gacaagtttt tactaatata gtcaatcgct
    13201 ccaattcgtc tacgatatgt cagcggcgca tacttatcat atgcggtaac aaagatgatc
    13261 tgtgcatttt catcctgctt cttgatgaat tccgctaagt ctaccccatt ttttgcttca
    13321 gattgctggc ttaattcaat atcaagaaag taaatgccat tcttaatatc attagccaca
    13381 atatagccaa caacctgtgc aaaatcatta gctacaaaag tcaccctttc ttttaactca
    13441 ctataactag aattatcacc ggctaaatct tgaattgcac tattaatatt agtagctaat
    13501 tgattagcca aatcaggatc atcatcacaa acaataatag gataattagt agtcactatc
    13561 ttcatcacca tcttccgtat caatcaccat gtagaagtca aaccagccat cttgaaccat
    13621 gtatgagact gacatatcag gatacttttc tcctaatttt ctaatattag ctaaaccata
    13681 accctgatgt ccctttttag ttgtaaaacc ttgttcttgt atttggctag tagagatctt
    13741 ttgatcttta cgcactctat tacgaatttc aaattcaaag ttattcggtc catctgaata
    13801 agccataatt tgaatctctt catactccgg agatttattc tttttagcca tatcctttat
    13861 aatcttgctt tcctcaattg cattatcgaa agcaattcct aggattctaa caagatccaa
    13921 ttcaccaata ttagccggca gtttttttac actgcctcta cattcaaaat tataagggat
    13981 tttaagatta tacatctctg ctaacttggt aataatgatg cttttaatcg attttacatg
    14041 aacataattt acatccttat actttgatag cgccgcagga tctaaacttg agttagtctc
    14101 ttcatccaat ttatgaatta ctgcttgaat atcaccctct tgagcataca attttaatga
    14161 gtttaagaca ttttggtagt catgtttaaa ttgtcgaaga tcatcctcac tatcttcaag
    14221 atatttggta tattcttcga gctgtctttg tttatctagt ttatttaatt gcttttccct
    14281 attaataagt tgcgcttgca ttcttaaaat aaaaacataa gcaacaccca caaatagcaa
    14341 ctgcaaaatt aataataacg aaaaaatagc agtagttaga taactttgct ttataaaaat
    14401 cttgacttcc agaataataa gaattgaaat ataaaagtaa attaataatc caactattat
    14461 tttattattt ttgctttcta attgataacg tattttatta cttaacttaa ttacaaaata
    14521 gaaaacaaga atataaaata agagaactac tacttccatc cataaaattt gtgtagatgc
    14581 tatattaaat atttgattta gcacatccac cattaagtca aatattagtg gtacaatccc
    14641 tgctcctaca agtacaaaag gattcctaat ttctttccaa aaaaataaaa atattaga
//
